Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance
Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma
Direct Cytosolic Delivery of siRNA Conjugates: A Paradigm in Antiangiogenic Therapy for Choroidal Neovascularization
Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex
Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial
Exosome-mediated siRNA delivery targets antibiotic resistance in bacteria
Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles
Ionizable polymeric micelles (IPMs) for efficient siRNA delivery
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers
Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening
Revealing New Analytical Insights into RNA Complexes: Divalent siRNA Characterization by Liquid Chromatography and Mass Spectrometry
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
Nanoparticles Codelivering mRNA and SiRNA for Simultaneous Restoration and Silencing of Gene/Protein Expression In Vitro and In Vivo
Arabidopsis SGS3 is recruited to chromatin by CHR11 to select RNA that initiate siRNA production
Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer
Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors
Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery
Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes
Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo
Virus-specific Dicer-substrate siRNA swarms inhibit SARS-CoV-2 infection in TMPRSS2-expressing Vero E6 cells
siRNA: From Bench to Clinic
Enhanced In Vitro and In Vivo Autophagy Suppression via LC3 siRNA-Loaded “Smart” Nanoparticles and Doxorubicin Combination Therapy in Triple Negative Breast Cancer
Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR–Cas gene editing
Unexpected discovery opens doors for improved siRNA therapies
Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis
RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain
Novel siRNA backbone developed at UMass Chan enhances stability, durability of potentially therapeutic platform
Two firms launch for siRNA drugs
Expanding the Analytical Toolbox for the Nondenaturing Analysis of siRNAs with Salt-Mediated Ion-Pair Reversed-Phase Liquid Chromatography
Abstract 4141288: ETX-291: A GalOmic™ siRNA for the Treatment of Cardiometabolic Disease
Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery
siRNA-Mimetic Ratiometric pH (sMiRpH) Probes for Improving Cell Delivery and mRNA Knockdown
Structure–Activity Relationship of Antibody–Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody–siRNA Conjugates for Drug Development
Small-Interfering RNA Shows Cumulative Lp(a) Reduction With Successive Doses
Dosage-sensitive maternal siRNAs determine hybridization success in Capsella
Targeted Delivery of BCL-2 siRNA Using Modified Ferritin Nanocarriers for Antitumor Therapy
Abstract 4139191: ETX-258 - A GalOmic™ siRNA for the Treatment of Heart Failure Following Myocardial Infarction
siRNA therapy lowers triglycerides in patients with rare condition
Non-viral vectors combined delivery of siRNA and anti-cancer drugs to reverse tumor multidrug resistance
RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain
Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA
Evolution of Lipo-Xenopeptide Carriers for siRNA Delivery: Interplay of Stabilizing Subunits
MMP-2 Responsive Gold Nanorods Loaded with HSP-70 siRNA for Enhanced Photothermal Tumor Therapy
A pH-Sensitive cRGD-PEG-siRNA Conjugated Compound Targeting Glioblastoma
Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer
Dual-Action Protein-siRNA Conjugates for Targeted Disruption of CD47-Signal Regulatory Protein α Axis in Cancer Therapy
Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery
Differential RNAi efficacy of siRNA and dsRNA targeting key genes for pest control in Spodoptera litura
Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases
Figure 6. Impact of 3'-exNA modification on siRNA potency in the CNS....
Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia
Solving the side effect problem of siRNA drugs for genetic disease treatment
Targeted suppression of siRNA biogenesis in Arabidopsis pollen promotes triploid seed viability
Two siRNA firms launch
Figure 3. Internalization and cellular uptake pathway of PTMS/Cy5-siRNA...
Eight biotech companies advancing the field of siRNA
Figure 4. In vivo distribution of AD/siRNA complexes in C57BL/6 mice...
siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study
Novel ferritin-based siRNA delivery system shows promise for targeted glioblastoma therapy
Novel injectable polypeptide nanoparticle encapsulated siRNA targeting TGF-β1 and COX-2 for localized fat reduction I: Preclinical in vitro and animal models
Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells
(PDF) siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction
Small Interfering RNAs (siRNAs) Negatively Impact Growth and Gene Expression of Environmentally Relevant Bacteria in In Vitro Conditions
Therapeutic siRNA: state of the art - Signal Transduction and Targeted Therapy
Misaa'ela haaran Israa'el yeroo jalqabaaf waraana Gaazaa keessatti fayyadamte
HER2 siRNA Facilitated Gene Silencing Coupled with Doxorubicin Delivery: A Dual Responsive Nanoplatform Abrogates Breast Cancer
Mechanism of siRNA in silencing target gene. Precursor RNA was combined...
Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy
Small interfering RNA (siRNA) timeline—discovery to regulatory approval...
Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis | Communications Biology
siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects
Where should siRNAs go: applicable organs for siRNA drugs | Experimental & Molecular Medicine
Imaging small molecule-induced endosomal escape of siRNA
Single-cell quantification and dose-response of cytosolic siRNA delivery
BBB pathophysiology–independent delivery of siRNA in traumatic brain injury
Current Development of siRNA Bioconjugates: From Research to the Clinic
Carbon nanocarriers deliver siRNA to intact plant cells for efficient gene knockdown
Specificity of short interfering RNA determined through gene expression signatures
Knocking down barriers: advances in siRNA delivery
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
Sticky overhangs enhance siRNA-mediated gene silencing
An siRNA-guided ARGONAUTE protein directs RNA polymerase V to initiate DNA methylation
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Reversal of siRNA-mediated gene silencing in vivo
Sirna named to equal opportunity post
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)
Phase separation of SGS3 drives siRNA body formation and promotes endogenous gene silencing
Knocking down disease: a progress report on siRNA therapeutics
Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A
Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages
Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device | Nano Letters
Investigation of the ionic conditions in SiRNA-mediated delivery through its carriers in the cell membrane: a molecular dynamic simulation
A pathogen-inducible endogenous siRNA in plant immunity
Systematic optimization of siRNA productive uptake into resting and activated T cells ex vivo
Summary of siRNA Drugs by condition, approval date, administration route, and frequency.