boasts a population of approximately 571 000 residents Essen has successfully transitioned from its industrial past to emerge as a model of urban regeneration and sustainable development The city has introduced extensive green and blue corridors emphasising its commitment to green infrastructure most notably showcased through the development of the Krupp Belt Essen's plans for its municipal forests focus on sustainable woodland management aiming to promote forestry practices that align with environmental conservation goals the city is actively identifying and encouraging the growth of tree species that are more resilient to the impacts of climate change Recognising the critical role of street trees in adapting to climate change Essen has engaged the public through educational tours raising awareness about the environmental benefits of urban greenery Essen implemented a strategic noise map in 2011 Citizen participation played a significant role in shaping these noise reduction plans allowed residents to pinpoint noisy areas on the map submit suggestions for improvements and provide feedback on proposed measures Essen's noise management strategy includes ambitious targets such as ensuring that designated quiet zones are located within 300 meters of where at least 51% of the population lives or works The information provided in this page reflects the context and circumstances at the time of applying for the EU Green Capital Award and may not fully align with current developments or standards The modern conscious consumer has required brands and manufacturers to examine their ethos Essen had ten community gardens and in just a few months this has increased to fifteen Three more are currently in development with a total of twenty expected by the end of Essen’s European Green Capital year Essen native Nils Mosh has a creative way of capturing life in the European Green Capital 2017: he records sounds around the city and posts them on his blog Teresa Deckert moved to Essen five years ago to undertake her Masters in Urban Culture Society and Space at the University of Duisburg-Essen – a fitting topic to have studied in a European Green Capital A southern Alberta egg farmer was jailed after missing a court date in his fight with the provincial egg marketing agency over how many hens he is allowed to keep outside of the quota system Henk Van Essen was released late last week after he promised to let inspectors from Egg Farmers of Alberta inspect his operation which is located between Turin and Iron Springs The agency is also seeking details on his sales volumes and his customers for the past four years which is quite a ways from the closest town,” said Van Essen who had incubators hatching chicks at the time of his arrest Bunge Global’s $34 billion merger with Glencore-backed Viterra is being stalled by trade tensions between the U.S Family members cared for the farm while he was incarcerated for two nights If inspectors find he has more than 300 laying hens he will be above the maximum allowed without a production quota under supply management Van Essen sells Canadian Food Inspection Agency-inspected graded eggs under the Sundial Poultry label to grocery stores The CFIA recently renewed his premise licence for two years You can’t make a living under 300 chickens,” he said “Whatever they count over 300 they are going to ‘de-populize.’ ” Hens typically range between 250 and 330 eggs per year with a prime laying window between 20 and 78 weeks of age “I’m having a hard time making mortgage payments right now He said he tried twice unsuccessfully to get quota under the EFA new entrant program which allocates a percentage of new quota allocations to applicants in lots of up to 1,500 birds Purchasing quota outright when it comes available through the quota exchange is too expensive producers must pay a levy of $0.005 per dozen eggs to the Alberta Egg Commission “I’m just a little farmer trying to make a living,” he said “There is a big shortage of eggs (avian flu outbreaks in British Columbia and the United States) and all the existing producers just got another 10 per cent (quota) given to them but they won’t let a little guy running a couple thousand chickens with the best eggs in town.” He has wanted to be a chicken farmer his whole life,” said neighbour Erik Sinke who added locals refer to Van Essen as “Chicken Henk.” said by email that the organization has been in regular contact with Van Essen for several years about him raising several thousand laying hens without allotted quota and directly selling his egg production in competition with regulated egg farmers Van Essen to ensure he was producing and selling his eggs in accordance with provincial regulations,” Webb said Van Essen was wholly unco-operative and intransigent in his position that he could do as he pleased without regard to the law eventually forcing EFA’s hand to compel his compliance with Alberta’s egg regulations via court application that has now spanned nearly four years.” Newsletter Sign Up - Receive free Western Producer newsletters Breaking ag news stories and commodities markets snapshots delivered daily right to your inbox Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Canterra buys pedigreed seed firm Alliance Seed Parrish & Heimbecker acquires bulk marine export terminal in Quebec City Terms and Conditions | Privacy Policy | © 2025 Western Producer Publications Limited Partnership "(Required)" indicates required fields Δdocument.getElementById( "ak_js_2" ).setAttribute( "value" Game Recap: Women's Basketball | 2/23/2025 6:12:00 PM | Nick Kapatos Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Steffen Essen used to drive to the liquor store in his pickup at 7:30 a.m. 2024 – the facility’s first-year anniversary – with his one-year sobriety coin in hand He wanted to share it with the SummitStone Health Partners team at Longview as a token of his deep appreciation who bounced between stints in substance-use treatment and glimpses of sobriety for much of his adult life Substance-use disorder, or addiction, doesn't discriminate based on age, race, spirituality or income. Essen is one among about 40.3 million people, ages 12 years and older, who reportedly have a substance-use disorder in the U.S., national data show.  The disease is treatable but often brings with it layers of complexity and hardship for the people suffering from it and those around them Essen was maybe 7 years old when he got his first taste of alcohol Thirsty from cutting firewood while camping with his dad he couldn’t reach the water and grabbed what he didn’t know then was boxed wine between Loveland and Berthoud – milking cows before and after school He and his traveling buddies would drive 1,000 miles and crawl so there was no place for drinking or doing drugs They used ibuprofen and Tylenol to numb their pain.  wearing a gray and white button-down shirt with pearlescent buttons and brown cowboy boots as weathered as his hands.  He was never a “bar guy” but started having a beer and then four with dinner after his 12-to-14-hour workdays He knew he had a problem when he couldn’t stop It got in the way of work and relationships So many people do get hijacked by alcohol,” said Essen who has a “lot of resentment” toward the substance Essen apologized often for pausing while telling his story in March 2025 as he looks west out of the windows at Longview toward the Larimer County landfill where trucks crawl back and forth across the dusty landscape.  associated with chronic alcohol misuse and severe alcohol-use disorder He struggles to remember long periods of his life and neurologic symptoms have made it difficult for him to live normally.  His 40s were a blur of sober periods and a revolving door of regional treatment centers marked by near-death incidents – from comas to car crashes and a team of behavioral health professionals fought all along to get him help.  “I would also say that Remi kept you alive,” said Jamie Powell and program supervisor for SummitStone Health Partners which is contracted for services at the Acute Care facility at Longview campus.  Essen agrees with his therapist and pets Remi the apricot-colored standard poodle he adopted as a puppy Remi has not only grown in stature since that day in 2019 but he’s grown in connectedness with the man he protects in his role as Essen’s service dog they are “best friends,” who go everywhere and do everything together The Acute Care facility at Longview campus has few peers across the nation public-private partnership between Larimer County and longtime nonprofit SummitStone Health Partners pharmacy and more – Longview offers all of it in one place Powell and Essen’s neighbors worked together to get him to Longview One neighbor took care of Remi – a barrier for many seeking treatment – and another Essen had been turned away from other treatment centers in the past because of his serious medical conditions but the Acute Care facility was designed to be different Led by innovators in their respective fields the Acute Care team takes an integrated approach to caring for each client’s body work as one to provide higher levels of care that weren’t previously available in one place in Northern Colorado Longview had a place for Essen that day in December 2023.  and licensed addictions counselor and licensed clinical social worker did Essen’s assessment that morning and admitted him onto the withdrawal management unit.  she saw Essen for the first time since he was discharged from care They came together to increase awareness of substance-use disorder and the power of treatment “We don’t get to see that and get to close the door for ourselves,” Montes said of her and so many behavioral health professionals who see people in their hardest moments but don’t know how things turn out after they leave their care for the team of SummitStone staff who were there in December 2024 when he came back with his sobriety coin “It was such a powerful story for not just me but for all of the staff to hear.” who grew up in the community and has always been a helper believes it’s unfair that substance-use disorder is stigmatized “unlike other chronic conditions.” Addiction is for each person to find the “magic combination” that works best for their treatment that may be receiving initial care at Longview followed by participation in a 12-step program; peer support; or doing individual group or family therapy alongside prescribed medications to control cravings “I absolutely believe that recovery is possible for every single person,” she said Essen said he’s hard on himself and talks often about personal accountability.  “The problems in your life are self-inflicted scratching the top of Remi’s slightly balding head.  Powell says: “I just want to push back on that Your brain was telling you you needed it to survive and the two laugh easily about their disagreement showing the trust that has been built between them.  “Learning to love yourself and forgive yourself and move forward.”  Essen is due in Larimer County court for legal issues associated with past alcohol use He is ready and willing to accept the consequences of his actions and continue his journey no matter what happens next.  Madeline NoveyCommunication SpecialistBehavioral Health Services970-619-4255noveyme@co.larimer.co.us Categories Type in search terms and click the (search) button -OR- Press the Enter Key on your keyboard to begin your search Categories appear once the search form is submitted You can use the show more button below when you have more than 10 results BATON ROUGE — On Saturday and Sunday night multiple lanes on Interstate 12 eastbound will be closed between the I-10/I-12 split to Essen Lane as crews remove temporary barriers the state Department of Transportation and Development announced Additionally, I-12 westbound between Essen Lane to College Drive will have a left lane closure on Saturday from 9 p.m. to 7 a.m., as well as Sunday from 9 p.m. to 5 a.m. for temporary barrier installation as part of the ongoing College Drive Flyover Project. 2025 /PRNewswire/ -- Essen Health Care a leading multi-specialty healthcare provider committed to advancing health equity has announced a groundbreaking partnership with OwnaHealth an innovative healthcare organization dedicated to reducing the impact of diabetes and obesity through personalized lifestyle and nutrition adjustments This collaboration aims to improve health outcomes for Essen Health Care's patients throughout the Bronx and and other underserved populations across New York City Founded and led by Harvard-trained endocrinologist Dr clinically validated approach to managing diabetes and obesity with a particular focus on hard-to-treat Medicaid populations Essen Health Care patients will have access to OwnaHealth's customized clinical and lifestyle management programs and behavioral resources to support complex healthcare needs Patients enrolled in OwnaHealth's program are paired virtually with a dedicated team of doctors available 24/7 to provide guidance and support OwnaHealth has achieved remarkable clinical outcomes "We are thrilled to bring OwnaHealth's proven sustainable solution to improve health and well-being to Essen Health Care's substantial number of Medicaid members," said Dr "Our partnership reflects a shared commitment to transforming lives especially in underserved communities in the Bronx by addressing diabetes and obesity with a personalized evidence-based approach that truly works." Founder and Chief Medical Officer of Essen Health Care emphasized the importance of this collaboration in advancing patient outcomes: "At Essen Health Care our mission has always been to provide high-quality compassionate care to those who need it most Our partnership with OwnaHealth allows us to enhance our ability to address two of the most pressing chronic conditions—diabetes and obesity—by leveraging innovative personalized care models that empower our patients to lead healthier lives we are setting a new standard for accessible effective healthcare in underserved communities." 18 de febrero de 2025 /PRNewswire-HISPANIC PR WIRE/-- Essen Health Care un proveedor líder de atención médica de múltiples.. 2025 /PRNewswire-HISPANIC PR WIRE/-- Essen Health Care a leading multi-specialty healthcare provider committed to advancing.. Health Care & Hospitals Medical Pharmaceuticals Hispanic Diversity, Equity & Inclusion Do not sell or share my personal information: Tova du Plessis's highly anticipated bakery is finally opening its doors in Kensington owner and pastry chef of Essen Bakery and Essen North / Photograph by Mike Prince Honestly, so have I. January 2023 was when Philly Mag first reported that the beloved East Passyunk bakery would be expanding into Kensington a four-time James Beard-nominated pastry chef sit-down cafe with house-made sandwiches for breakfast and lunch It would lean heavily into bagels and sell lox and schmear and fresh-roasted Elixr coffee making it an excellent space for remote workers and a hella convenient pit stop for commuters on their way to the Berks station Essen North will finally open its doors on the corner of Berks and Hope Streets A lot has happened since Essen’s expansion was announced — in the world What we didn’t know back in January 2023 was that du Plessis had just been diagnosed with narcolepsy type 1 a lifelong disorder of the sleep/wake cycle she went to a sleep clinic to figure out why she often felt exhausted and would experience muscle weakness whenever she got overexcited (a symptom of cataplexy Aside from telling those closest to her, du Plessis kept her diagnosis private. It wasn’t until the first anniversary that she went public with the life-changing news. “I am diagnosed with narcolepsy type 1. I have known this all year,” she wrote on Essen Bakery’s Instagram this past January Getting a diagnosis of a chronic neurological disorder is a lot to handle But what about getting that diagnosis while being a mother who runs one of Philadelphia’s most successful bakeries and is actively building out a second It was so hard,” she told me shortly after she went public In addition to managing an already pretty hectic lifestyle she now had to figure out a treatment plan that worked for her (As if striking a work-life balance wasn’t hard enough.) 2023 – Pastry chef Tova du Plessis at a construction site that would become Essen North I stopped by Essen North this past March to see how things were progressing it was still a construction site — a skeleton of wooden beams and cement floors covered in a potpourri of sawdust and drywall — but du Plessis had a pretty clear vision of what her new 2,800-square-foot cafe would look like “This is going to be the counter,” she said pointing to a steel frame jutting out in the middle of the room “This is where we’ll prepare coffee — we’ll be serving our own roast made by Elixr,” she added before leading me MTV Cribs-style into the shaping room “This is where you’ll be able to see the magic happen,” she said pointing to a window through which guests can watch bakers braid Essen’s iconic chocolate-halva babka through a wide doorway cut out of a brick wall “We’ll have communal dining tables here for seating during the day but we can also use this as an event space,” she said adding that they’ve designed the space specifically for private events and classes in mind Brad and Tova du Plessis / Photograph by Mike Prince The thing that has always struck me about du Plessis is the unwavering confidence she has in herself to tackle head-on whatever is thrown her way whether it be navigating narcolepsy or the persistent challenges that have delayed this project for nearly two years (you know and Philly being Philly — the usual reasons why most things get delayed in the restaurant industry) Everything she showed me back in March is still a go Everything she announced would happen two years ago is finally coming to fruition who quit his job earlier this year to become a partner and the managing director of both locations Essen North is finally making its big debut Stop by 110 West Berks Street this Friday at 8 a.m they’ll be open seven days a week from 8 a.m 16 Philly Restaurants Offering Passover and Easter Specials 10 Un-Brie-Lievable Philly-Area Cheese Makers and Mongers Meet the Chefs Reimagining the Cheesesteak By submitting the above I agree to the privacy policy and terms of use of JTA.org Rumors spread that the Israeli far-right politician might not be coming at all MIDWOOD, Brooklyn — Itamar Ben-Gvir’s trip to the United States took him to the headquarters of the Chabad movement in Brooklyn on Thursday evening, where the far-right Israeli security minister toured the building’s library and synagogue and posed with rabbis in front of a Torah ark The visit to 770 Eastern Parkway was a prelude to another iconic destination: cholent night at Essen New York Deli in Midwood Essen serves up the traditional Ashkenazi Shabbat stew that has become a fixture of late-night life in some Orthodox communities The message promoted “a Cholent & chill matzav,” the Hebrew word for situation that would include “a meeting and greeting & photos with the guest of honor.” All were welcome The tone was very different than at Ben-Gvir’s other local appearances. A Manhattan talk organized by Shabtai, a Jewish secret society based at Yale University shielded its location until just hours before it began then doled the details out only to registered guests presumably in an attempt to head off protests by Israelis Jews and others who say Ben-Gvir’s extremism places him outside the acceptable bounds of discourse And multiple synagogues that announced they would be hosting him publicly canceled the plans after pushback — including one near 770 that was raising money for Chabad in Hebron the West Bank city that is a flashpoint of the Israeli-Palestinian conflict Even at 770, local news reports emphasized that his visit was not officially organized by Chabad-Lubavitch World Headquarters, anchored in the building.Pro-Palestinian protesters, organized in part by the extremist group Within Our Lifetime, rallied outside the doors were wide open — if not designated just for Ben-Gvir The maître d’ clarified that customers would need to pay for their meal that Ben-Gvir would be dining there “as a guest” and that the event was not hosted by the restaurant would come “around 10:00 and 11:00 PM.” As the evening progressed the clientele evolved from young families out for dinner Not everyone said they were there for Ben-Gvir, who until recent years was considered too extreme even for Israel’s right-wing politicians because of his association with the extremist rabbi Meir Kahane and previous admiration of Baruch Goldstein a Kahanist who murdered 29 Muslims at prayer in Hebron in 1994 I couldn’t care less about politics,” said Zeev an Essen patron who declined to share his last name Zeev had come to Essen with a group of friends formalized in a WhatsApp chat called “Essen Thursday Night,” has been coming to the restaurant every week since they were seniors in high school Essen New York Deli is a popular cholent spot on Thursday nights in Midwood “We all just come here to just eat cholent,” said Joseph like Katz’s Deli and all these delis around that are barely even kosher Essen’s the spot for all of us that we all come to every Thursday night.” there was still no sign of the Israeli national security minister People were texting and calling their friends and neighbors to come see what was happening “I came for the hangout because I thought there were going to be other people here and I’d be able to meet some people,” said Jonathan a Borough Park resident who arrived with his friends and declined to give his last name who met at the Stephen Wise Free Synagogue a Reform congregation on the Upper West Side Jonathan praised Trump but demurred when asked his thoughts about Ben-Gvir “I haven’t given it a second thought,” he said the streets were packed with young men still hoping to get a glimpse of the Israeli politician who is a hero to those on the hardline right who believe Israel should prioritize defeating Hamas over all else and advance Jewish resettlement in the Gaza Strip (Those positions are held by only a minority of Israelis who won Midwood and other heavily Orthodox communities in the United States in last year’s election has called for Palestinians in Gaza to be resettled elsewhere en masse and for the United States to take over the enclave.) Rumors spread that Ben-Gvir might not be coming at all swarmed the vehicle and the minister’s entourage as they spilled out and he headed into the restaurant’s back room The protests that dogged Ben-Gvir in Manhattan and New Haven were replaced by excited yells and applause “You’re my hero!” one man called over the clamor Restaurant staff locked the exterior door momentarily preventing the crowds outside from pressing into the restaurant Some climbed atop the Avenue J and Coney Island Avenue bus stop bench for a better look inside Crowds pressed against the window of Essen New York Deli in an attempt to catch a glimpse of Israeli National Security Minister Itamar Ben-Gvir a kosher food and travel blogger from Los Angeles arrived just in time to see the last bit of action an Orthodox religious enclave on neighboring Long Island said they believed the minister was right to admire Kahane we all know what’s going to happen: that Jews and Arabs simply can’t really — it sounds very nice to say [but] it doesn’t really seem like we could live together in a lot of ways,” Yitzchak said He said there’s going to be terrorist attacks every week and he’s [Ben-Gvir] kind of continuing that mesorah,” Yitzchak added using a word denoting tradition or heritage “I’m not so involved with Israeli politics NEW YORK: Israeli National Security Minister Itamar Ben Gvir visits the popular ‘Essen on Coney’ restaurant in Flatbush. pic.twitter.com/fSw0ern95v — KolHaolam (@KolHaolam) April 25, 2025 Inside, Ben-Gvir shared a meal with dozens of local men, including “community leaders and askunim,” a Yiddish word roughly referring to movers and shakers, according to BoroPark24, an Orthodox news outlet The outlet said Ben-Gvir had earlier stopped by a hotel two miles away in Borough Park another Orthodox neighborhood with a vibrant minority of restive far-right activists and was expected to spend Shabbat in the Five Towns one synagogue where he had been advertised as speaking canceled the plan abruptly on Thursday which Ben-Gvir’s office said was because the planned moderator had suffered a death in his immediate family he posted a victorious message about his crackdown on Israeli prisons The New York Jewish Week brings you the stories behind the headlines, keeping you connected to Jewish life in New York. Help sustain the reporting you trust by donating today I accept the Privacy Policy There are no statistics available for this player Thanks for visiting Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInMADISON (WMTV) - The development of a property that houses beloved German beer hall and restaurant Essen Haus has been postponed and the restaurant will remain open indefinitely Customers and employees with Essen Haus and Come Back In were under the impression that the establishments would be demolished come August. The redevelopment process has now been delayed “With any development of a substantial size it’s inevitable that there can be delays,” manager of over 30 years Neale Hansen said Hansen says staff are happy to take advantage of the postponed closure “But you’re having people where they’re bringing their parents through 50th and 60th wedding anniversaries It wasn’t that long ago we had somebody that had their birthday here and they were almost an octogenarian,” he said it feels good that they trust you to handle these milestone events.” manager and daughter of owner Bob Worm says many memories have been made over the last 42 years the potential closure has brought many of them to light “It was also really outstanding to see staff members that had formerly worked here or come and say can I come out and help out for a couple shifts Staff say they will be there until the very end “And especially when the guests are asking us I’m just so grateful to have our regular customers and staff just be on board with the unknown.” The annual Essen Haus Thanksgiving Dinner will happen this year The manager also said they have already started to book musicians ahead of New Year celebrations Click here to download the WMTV15 News app or our WMTV15 First Alert weather app Metrics details Differentiating neoplastic and non-neoplastic uveal tumours can present a diagnostic challenge; intra-ocular biopsy may be necessary The novel trans-scleral Essen Forceps biopsy (TSEB) technique can improve diagnostic yield compared to fine needle aspiration biopsy (FNAB) We present a case demonstrating the technique and its added value We also review the success rate of TSEB performed at two tertiary eye centres Retrospective case report and consecutive case series from August 2021 to March 2023 Inclusion criteria were patients who underwent TSEB of posterior uveal lesions from Moorfields Eye Hospital and Sheffield Teaching Hospitals in the United Kingdom The outcomes were biopsy success rate and complication rate Eleven biopsies met the inclusion criteria one melanocytoma and one extranodal marginal zone (ENMZ) lymphoma One TSEB did not yield tissue for histological examination because of perioperative sample handling Two (18%) biopsies were histologically inconclusive; both were treated as uveal melanoma on clinical grounds or repeat biopsy The only complication was vitreous loss and retinal hole without retinal detachment in one eye with a very posterior TSEB is an effective alternative to established biopsy techniques yielding larger tissue samples than FNAB with intact tissue architecture We recommend adding TSEB to the armamentarium of the ocular oncologist The Essen forceps were designed for transvitreal approach biopsies we describe our experience of using the Essen forceps to take tumour biopsies ab externo utilising a partial-thickness scleral flap technique This study describes the technique and reviews the success and complication rates of trans-scleral Essen biopsy (TSEB) technique performed at two tertiary ocular oncology centres in the UK We also report an illustrative case highlighting the added value of TSEB in selected cases We retrospectively reviewed medical and histopathological records of patients undergoing uveal TSEB at two national ocular oncology centres: Moorfields Eye Hospital The biopsies took place between August 2021 and March 2023 Approval was obtained from the Audit Department of Moorfields Eye Hospital (1331) The study adhered to the tenets of the Declaration of Helsinki Data collected included patient demographics success rate (measured as a biopsy that yielded a tissue diagnosis) Following scleral exposure and marking of the tumour site a fornix based partial thickness scleral flap is created (A) with the hinge over the thickest part of the tumour a 2-3 mm full thickness sclerostomy is created with a blade (B) giving access to the intraocular structures The Essen forceps is passed into the lesion to be biopsied with the jaws open (C) The forceps are closed and the tissue sample remains within the jaws of the forceps (D) The tissue is placed on sterile card under the microscope to ensure the samples are safely retrieved (E) This process is repeated as often as necessary sampling different parts of the lesion of interest each time the forceps should be passed along the inside of the sclera parallel to the plane to avoid perforating retina To minimise the chance of tumour cell seeding the flap is closed by applying a small drop of cyanoacrylate glue (F) The flap is rapidly closed (G) with gentle pressure over the sclerostomy using a cotton bud further glue can be applied to ensure full closure or 9-0 non-absorbable sutures can be pre-placed at the flap corners All biopsies obtained with this technique were fixed in standard 4% neutral buffered formalin and processed with standard pathology techniques to paraffin wax blocks stained with haematoxylin and eosin (H & E) and examined with a standard light microscope paraffin sections were exposed to appropriate immunohistochemistry and ancillary molecular genetic analysis A Optos widefield fundal imaging at initial presentation with acute red eye B Optos widefield fundal imaging three months after presentation following treatment with topical steroids There was no regression in the choroidal lesion and subtle growth at the superior edge C B-mode ultrasound of the choroidal mass at presentation 2.1 mm (height) × 11.7 mm (longitudinal base) × 14.3 mm (transverse base) slow internal blood flow as the recorded velocity in one vessel was 1.8 cm/s D Histopathology of the specimen from the trans-vitreal biopsy of the right choroid which included tiny clumps of atypical cells E Histopathology specimen obtained by Trans-scleral Essen Forceps biopsy (TSEB) of the right eye stained with H & E at low magnification This shows fibroconnective tissue with scattered melanin and an infiltrate of atypical cells with hyperchromatic nuclei Optical coherence tomography (OCT) through the area of the mass showed and irregular surface profile and trace subretinal fluid. B-scan ultrasound (US) confirmed a shallow choroidal mass, 2.1 mm in thickness, with a base of 11.7 mm × 14.3 mm, with low to medium echogenicity (Fig. 2C) There was minimal internal blood flow on Doppler US the clinical picture suggested an inflammatory aetiology with associated choroidal mass The differential diagnosis included nodular scleritis choroidal metastasis from an unknown primary The patient was commenced on a trial of topical dexamethasone eye drops and monitored closely Topical steroid treatment improved the symptoms of swelling and redness. However, dilated fundoscopy three months after presentation showed the choroidal lesion had not regressed (Fig. 2B) The patient was concurrently referred for systemic screening for a possible unknown primary malignancy and underwent trans-vitreal biopsy of the choroidal mass using a 25 G vitreous cutter including whole-body positron emission tomography-computed tomography (PET-CT) magnetic resonance imaging (MRI) head and neck and dermatology assessment License: Permission granted by D.O.R.C to use images for research purposes on 02/08/2022 Histopathological examination of the TSEB revealed several 1 mm fragments with intact tissue architecture. This consisted of fibroconnective tissue with scattered melanin, consistent with choroidal origin. An infiltrate of atypical cells with hyperchromatic nuclei was also identified (Fig. 2E) The atypical cells were immuniohistochemically positive for HMB45 and Melan-A and negative for cytokeratins Subsequent genetic analysis of the tissue revealed loss of chromosome 3 and gain of chromosome 8: supporting a diagnosis of primary uveal melanoma with increased metastatic potential The patient subsequently underwent treatment of the choroidal melanoma with Ruthenium 106 brachytherapy at a dose of 100 Gray to the apex and continues under surveillance for metastasis as per local protocol Data were extracted for 17 intraocular TSEB cases, of which 11 were of the posterior uvea and, therefore, eligible for inclusion. The details are summarised in Table 1 ten biopsies yielded informative samples (91%) with eight (73%) providing a tissue diagnosis and were therefore ‘diagnostically successful’ Two (18%) biopsies were histologically inconclusive despite yielding copious tissue; one was treated as choroidal melanoma based on clinical features and the other underwent a subsequent trans-scleral incisional biopsy which confirmed choroidal melanoma One (9%) TSEB failed to yield any uveal tissue The sample was inadvertently mishandled peri-operatively after the biopsy site had been sealed while being transferred to the specimen pot It is likely that the sample was lost in this process as no other TSEB failed to yield tissue This patient was treated as a presumed metastasis from a known disseminated primary adenocarcinoma This study details the trans-scleral Essen Forceps biopsy (TSEB) technique in posterior uveal lesions the biopsy sample achieved was superior to that obtained trans-retinally using the 25 G vitrectomy cutter completely changing the diagnosis and management of the patient A second biopsy could have been attempted by FNAB or incisional partial lamellar sclerouvectomy (PLSU); however the lesion’s posterior location and shallowness rendered access challenging and higher risk for retinal puncture As the surgeon visualises the uveal tissue during the procedure there is less risk of non-diagnostic biopsies as the surgeon can complete further passes until tissue is retrieved Handling of the tissues is easier with Essen forceps than with the use of standard forceps and its blunt tip is less likely to perforate the overlying retina histopathological and immunohistochemical analyses were non-diagnostic most likely due to the limited amount of tissue sampled The authors do not believe that TSEB is more vulnerable to this limitation than other biopsy techniques but further study with larger cohorts is warranted the location of the tumour would have made surgical incisional biopsy difficult and would have risked non-diagnostic biopsy or retinal penetration due to the shallow tumour this was not available at our services during the study period the technique yields much more tissue with more intact architecture This allows easier histopathological interpretation of the pathology and permits numerous ancillary diagnostic tests such as immunohistochemistry and molecular pathology for diagnosis conformation and prognostication This study is limited by its retrospective nature and small sample size the available instrumentation and cost have not been examined Further study with a larger cohort is warranted to continue to refine the indications and technique of TESB Diagnosing posterior uveal tumours can be challenging in atypical cases Essen forceps biopsy using a trans-scleral approach can enhance tissue sample quality and size in selected lesions therefore increasing diagnostic accuracy with minimal risk We recommend considering trans-scleral Essen forceps biopsy within the armamentarium of the ocular oncologist Identifying uveal melanoma may require intra-ocular biopsy in atypical cases Established techniques include fine needle aspiration biopsy (FNAB) and trans-vitreal biopsy using vitreous cutters and Essen Forceps The trans-scleral Essen Forceps biopsy (TSEB) technique can improve diagnostic yield in atypical cases of uveal melanoma without compromising safety The data that support the findings of this study are available from Moorfields Eye Hospital and The Royal Hallamshire Hospital Sheffield but restrictions apply to the availability of these data which were used under license for the current study Posterior Scleritis Simulating Choroidal Melanoma: A Case Report Posterior scleritis as an intraocular tumour A case of giant nodular posterior scleritis mimicking choroidal malignancy Nodular posterior scleritis mimicking choroidal metastasis: a report of two cases Biopsy in indeterminate intraocular tumors Masquerade Syndromes: Malignancies Mimicking Inflammation in the Eye Uveal Melanoma in the Peripheral Choroid Masquerading as Chronic Uveitis Choroidal biopsies; a review and optimised approach Transvitreal fine needle aspiration biopsy: The influence of intraocular lesion size on diagnostic biopsy result Intraocular biopsy using special forceps: a new instrument and refined surgical technique Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach Damato B, Angi M, Coupland SE, Heimann H, Groenewald C. Miscellaneous Uveal Biopsy Techniques. In: Damato B, Singh AD, editors. Clinical Ophthalmic Oncology: Uveal Tumors. Berlin, Heidelberg: Springer; 2014. https://doi.org/10.1007/978-3-642-54255-8_4 Transretinal Choroidal Tumor Biopsy with a 25-Gauge Vitrector Fine-needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review Diagnostic incisional biopsies in clinically indeterminate choroidal tumours Choroidal Biopsies for Intraocular Tumors of Indeterminate Origin Vitreoretinal Surgery for Complications of Choroidal Tumor Biopsy Download references The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology The views expressed are those of the author(s) and not necessarily those of the NHS NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology VO was responsible for extracting and analysing data project administration (including resources and validation) revising the manuscript and giving final approval of the version to be published HSM was responsible for interpreting the results HQ was responsible for overall supervision The authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41433-024-03394-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Boru Ramen and Sweet Society are moving from Mid City into the former Copeland's/Batch 13 building on Essen Lane The two restaurants are expected to complete the move into 4957 Essen by mid-January The 7,500-square-foot building has been vacant since early 2020 Boru Ramen and Sweet Society are owned by the Wong family The two businesses had been in the Electric Depot development on Government Street since 2020 Is there a building under construction or renovation in your neighborhood and you want to know what it is? Send an email with a picture or the location to tboone@theadvocate.com Email Timothy Boone at tboone@theadvocate.com This story is only for subscribers like you${formattedName Email notifications are only sent once a day News Tips:newstips@theadvocate.com Other questions:subscriberservices@theadvocate.com Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: reflecting on the 2024 Essen Motor Show (EMS) despite spending three full days at Messe Essen it still feels like I missed many of the cars on display The end of EMS marks the approach of my sixth year as a Speedhunter – the dream job I fell into accidentally There’s no need for champagne yet; I’ll save that for another time Let’s get back to business: eight halls packed with some of the wildest oldest and fastest machines Europe has to offer the Essen Motor Show was founded by 25-year-old car enthusiast Wolfgang Schöller in 1968 as the ‘International Sports and Racing Car Exhibition Essen.’ Much like the SEMA Show what started as a humble affair grew into the enormous event we know today the event was rebranded as the ‘Essen Motor Show’ with a shift in focus from motorsport to a broader celebration that included the aftermarket and tuning industries A quick walk through the halls is all it takes to see that’s still the case today with modified cars and aftermarket parts everywhere you look Several Touring and GT4 cars immediately caught my attention especially the Risse/Send Motorsport Opel Kadett Coupé GT/E Opel has a rich motorsport heritage across Europe its Vauxhall namesake isn’t quite as well regarded Opel’s motorsport history is far more impressive than most people realise and I’d love to dive into that at some point John Cleland is a British Touring Car Championship legend but seeing his name on this South African Astra GSi Super Tourer shows Opel’s racing pedigree far beyond Vauxhall and the BTCC On my first and only other visit to EMS in 2019 but nothing like the number of EVs present this year the entrance to the show still features race cars and smaller tuners but the first car I saw inside Hall 7 was a modified Volvo EX30 not only showcased their four-wheeled offerings but also a stunning two-wheeled BMW Motorrad creation Eisenmann Exhaust Systems exhibited a G80 M3 on F1-inspired wheels a very love-or-hate choice judging by the reactions from the crowd Bilstein had World Rally Championship legend Walter Röhrl on its stand where he signed autographs and posed for photos beside a BMW M4 and a rally-spec G-body Porsche 911 it was a gorgeous 2.7-litre E21 BMW on the Dbilas Dynamics stand that caught my attention Dbilas is renowned for crafting some of the finest intake manifolds and carburettor setups – and when I was planning a big-power BMW M30 engine build their ITBs were the only option I considered It’s impossible to talk about EMS without mentioning Jean-Pierre (JP) Kraemer and his team from JP Performance The German tuning scene is notoriously hard to break into due to the stringent TÜV standards and the high cost of obtaining approval for parts is that if someone is brazen enough to build the outrageous cars that German authorities hate they’re likely to gain fame in the industry boundary-pushing builds have earned him a well-deserved place at the top Vlad previously went into some detail about JP’s empire and his success is clear with two back-to-back stands at EMS 2024 featuring three outrageous builds JP’s newest creations are a V12-swapped Mercedes-Benz SLC and the ‘Volto’ – a Volvo 850 with a space-frame chassis and electric powertrain they displayed the new GT500 and the massive Shelby Raptor Though I may be slightly biased in my preference here… There was something for everyone at EMS 2024 – from live and competitive sim-racing sessions to RC drift displays and real-life driving demos whether you’re after memorabilia or a fur coat (yes I had to stop myself from buying a genuine poster of a BMW M3 GTR Strassenversion because prices at shows tend to be outrageously high Just like I would have never forgiven myself had I forgotten to include the all-E36 BMW stand The Tuning Experience hall was packed with so many show-and-shine cars that I’m working on a separate feature for them I also have stories planned on some DTM legends and a quirky European race series that caught my eye I’ll leave you with my star of the show – or shall I say The Koenig Specials R107 Mercedes-Benz SL in metallic black/blue with gold detailing and a white leather interior was as resplendent as it was outrageous Koenig Specials cars always hold a special place in my heart – not just for their outlandish looks but for their simple attitude and I’ll say it again: simple cars are often the best The 2024 Essen Motor Show 2024 was fantastic The show is really great – and that’s not just my nostalgia talking The 2024 Essen Motor Show on Speedhunters Could not stop looking at that Koenig Mercedes though Those old Koenigs are just <3If you haven’t already check out 1000sel.com (I’m not affiliated) - there’s a few hours spend walking besides the tuners of yesteryear Speedhunters is an international collective of photographers writers and drivers with a shared passion for uncovering the world's most exciting car culture stories The page you are looking for might have been removed Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInBATON ROUGE (WAFB) - Police have identified the person killed in a crash on I-10 West at Essen Lane Sunday morning According to the Baton Rouge Police Department Police said that Templet was driving a Nissan and lost control of her vehicle causing it to crash into a Mercedes and roll onto its side The driver of the Mercedes was taken to a hospital with moderate injuries They added that two passengers in the Mercedes were not injured Click here to report a typo Click here to subscribe to our WAFB 9 News daily digest and breaking news alerts delivered straight to your email inbox Last-minute prep and car culture go hand-in-hand You’d think you’d outgrow the rush as the stakes get higher but setup night at the Essen Motor Show (EMS) proves that’s far from the case but I prefer the chaos that comes before the doors officially open high-profile events like EMS often have a preview day for media and press before the public gets access to the halls Having early access is one of the perks of this job – not having to fight for a shot or dodge oblivious attendees standing right in your line of sight makes shooting event coverage much easier weaving through a ballet of cars being hurried into place avoiding forklift operators on frantic missions and trying not to trip over stacks of pallets and boxes is somehow even better but I wasn’t counting on a bird of prey to swoop past me and land majestically on a ledge a working falcon tasked with keeping Messe Essen’s halls free of pigeons while the shutters are open for the evening With the preview day today (Friday) plus two public days ahead for me (the show runs for a whole week December on Speedhunters will kick off with some of the best modern and classic tuning Europe has to offer I’ve also spent the past few days bouncing between Stuttgart and Munich, spending time around three of Germany’s legendary marques and getting up close with everyone’s childhood hero – the Need for Speed Most Wanted BMW M3 GTR – at BMW Welt I hope you’ve enjoyed this quick look at the manic energy and meticulous planning that goes into an event as massive as the Essen Motor Show but I’m saving the best for my main coverage More stories from Germany on Speedhunters Link IconCopy linkFacebook LogoShare on FacebookXShare on XEmailShare via EmailLink copied to clipboardEssen Bakery’s long-awaited greatly expanded second shop is finally opening in KensingtonEssen Bakery's Kensington location — with more than 40 seats and a full coffee program from Elixr — is opening on Nov To be a successful baker requires patience Just look at Essen Bakery’s second location opening Friday at Berks and Hope Streets in the Norris Square section of Kensington near the Berks station of SEPTA’s Market-Frankford line and steps from Gryphon Cafe and Suraya The Jewish bakery/cafe from four-time James Beard Award nominee/babka whisperer Tova du Plessis has been in the works for nearly two years which du Plessis attributes to contractor issues and permits but I’m learning that the more I lean into where I am today and the less I push myself to meet my crazy high expectations the more I am able to accomplish,” she said The new bakery‘s delay had at least one welcome side-effect joined her several months ago as her business partner A longtime wine sales executive last with KosherWine.com Brad du Plessis had largely remained apart from Essen aside from his unofficial role as a delivery driver during the early days of the pandemic Essen’s new location — with more than 40 seats and a full coffee program from Elixr — is significantly larger than the original which opened in 2016 on East Passyunk Avenue near Dickinson Street in South Philadelphia That spot has two tables and small counter “we’re going to be able to really take on the wholesale side of the business and grow that,” Brad du Plessis said “We currently have one or two wholesale customers and we get them as much as we possibly can.” Essen’s signature is the chocolate halva babka But after graduating from the University of Houston Tova du Plessis enrolled at the Culinary Institute of America’s campus in Napa Valley When du Plessis interned as a pastry chef at the Restaurant at Meadowood in St one of the guest chefs for its Twelve Days of Christmas series was Mike Solomonov of Zahav Solomonov and partner Steve Cook hired her for Citron & Rose the Main Line kosher restaurant that they briefly consulted for When Cook and Solomonov ended their affiliation with Citron & Rose du Plessis worked at Le Bec Fin in Center City during the end of its run and for its successor Her last job was executive pastry chef at the Rittenhouse Hotel Brad du Plessis changed jobs to cut down on his travel while Tova sought work that didn’t involve the long grind of hotel kitchens She heard that Jessie Prawlucki Styer was looking for someone to sublease Belle Cakery launching Essen and receiving James Beard nominations as Outstanding Baker in 2017 The page you're looking for does not exist Please try our site search feature to find what you are looking for This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Metrics details The Zagreb and Essen regimens are comparable in terms of immunogenicity; however how these regimens impact the immunogenicity of booster vaccination remains unknown We conducted a clinical trial to assess the immunogenicity of booster vaccination with a purified Vero cell rabies vaccine after primary vaccination with the Zagreb or Essen regimens conducted in Shangyu City and Shengzhou City was divided into the primary and booster vaccination phases all eligible participants were allocated to groups A and C received the Zagreb regimen as the primary vaccine The booster vaccination was conducted 6 months after the primary vaccination Groups B and E received one dose of the booster Blood samples were collected before the booster and at approximately 6 months after the booster Safety was assessed from the first booster dose to 6 months after the final dose A total of 718 participants completed the booster vaccination The antibody positive rate (APR) of groups B The antibody titer rose significantly even after one booster and was much higher in groups B (48.80 IU/ml) and C (64.38 IU/ml) (receiving Zagreb) than in groups E (34.25 IU/ml) and F (42.89 IU/ml) (receiving Essen) Although the incidence of ARs was higher in groups B (11.22%) and C (15.79%) than in groups E (3.68%) and F (10.87%) No serious adverse events (SAEs) associated with vaccination were reported The immunogenicity of booster vaccination after the Zagreb regimen was significantly higher than that after the Essen regimen One booster may be sufficient to raise the antibody titer above the 0.5 IU/mL target Clinical trial registration: This trial is registered at http://www.chinadrugtrials.org.cn/index.html under the registration number CTR20210426 at 08/03/2021 Despite the widespread application of the Zagreb regimen the immunogenicity and safety of the vaccine booster administered after vaccination with this regimen has not been thoroughly assessed we conducted a randomized clinical trial to compare the immunogenicity and safety of the purified Vero cell rabies (Speeda) vaccine when used as a booster at 6 months after the primary vaccination with the Zagreb and Essen regimens The booster vaccination study participant workflow The booster safety set (bSS) included the participants receiving at least one booster The booster per protocol set (bPPS) included the participants who completed the booster vaccination provided blood samples before and at 14 days after receiving the booster The immune persistence set (IPS) included the participants who completed the booster vaccination and provided blood samples at 12 months after the primary vaccination Blood samples were collected at 12 months after the primary vaccination from the first 100 participants in each group At day 0 (before the booster), the APR was 100% for each group, and the GMCs were 6.61, 6.74, 7.29, and 7.02 IU/mL for groups B, C, E, and F, respectively (Table 2) The APR (P = 1.0000) and GMC (P = 0.5124) were not significantly different among the four groups The GMC of booster vaccination. Geometric mean concentration (GMC) was derived by transforming the antibody titer by log10. At day 0, the statistical comparison was between all four groups; at 14 days after booster and month 6, the statistical comparison was between the groups with the same primary vaccination regimen or the same booster dose. *P > 0.05, **P < 0.05, ***P < 0.001. The geometric mean 4-fold increase rate (GMFIR) was defined as the proportion of participants who were antibody-positive before the booster and had a 4-fold antibody titer rise after the booster The statistical comparison was between the groups with the same primary vaccination regimen or the same booster dose but the antibody titer decreased over time We found a significant difference in GMC between groups B and C (P = 0.0088) or between groups C and F (P = 0.0235); this difference was not significant between groups B and E (P = 0.2464) or between groups E and F (P = 0.0719) The adverse reactions (ARs) were defined as the adverse events (AEs) associated with vaccination based on the judgement of the study investigators Most of these ARs occurred within 3 days after vaccination The most common injection-site AE was pain which were either associated with vaccination or caused patients to exit the trial The Zagreb regimen offers higher compliance rates and better cost-effectiveness than the Essen regimen These features of the Zagreb regimen have popularized its adoption across the globe over the past 20 years; however the regiment was not approved in China until 2010 is the only purified Vero cell rabies vaccine approved for use alongside the Zagreb regimen it is important to assess the immunogenicity and safety of administering the booster after vaccination with the Zagreb regimen we showed that the booster vaccination after Zagreb regimen was both effective and safe we observed a significant rise in GMC values after the booster vaccination the optimal vaccine potency and dosage are still under debate administering one booster elicited a lower antibody titer than administering two boosters even the one-booster regimen elicited significantly higher GMCs than 0.5 IU/mL with a GMFIR that was not significantly different between groups (i.e. These findings indicate that one booster may be sufficient to protect the exposed individual from rabies Given that rabies is an infectious disease associated with socioeconomic deprivation the most cost-effective vaccination regimen is conducive to rabies control not only raised the GMC rapidly above 0.5 IU/mL but is also the more affordable option for vaccinees whether extending the interval between vaccination with the Zagreb regimen and boosting with the Speeda will increase immunogenicity awaits to be seen our study demonstrated that the immunogenicity of the booster was greater when administered 6 months after the Zagreb regimen than when given 6 months after the Essen regimen one booster may be sufficient to induce adequate antibody levels to protect the exposed individual from rabies conducted in Shangyu City and Shengzhou City (Zhejiang Province China) between July 2021 and December 2022 All volunteers were screened before receiving the primary vaccination Eligible participants were healthy volunteers aged 10–60 years without a history of being bitten or scratched by a mammal capable of carrying rabies 6 months before vaccination without a history of rabies vaccination or rabies immunoglobulin administration and without a history of an acute allergic reaction The details of inclusion and exclusion criteria for primary vaccination are provided in the Supplementary material (Supplementary page 1) Written informed consent was provided by the participants (if aged 18–60 years) or the participants (if aged 10–17 years) and their guardians prior to study screening the participants who completed the primary vaccination and provided blood samples at 6 months after the primary vaccination in groups B and F were eligible for the booster vaccination The booster vaccination phase study design Group B received the Zagreb regimen as the primary vaccination followed by one dose of the booster vaccination Group C received the Zagreb regimen as the primary vaccination followed by two doses of the booster vaccination Group E received the Essen regimen as the primary vaccination Group F received the Essen regimen as the primary vaccination The day on which blood samples were collected from individuals due to receive the first booster was defined as Day 0 in the booster vaccination phase Blood samples were collected at 12 months after the primary vaccination which was approximately 6 months after the booster was given; this timepoint was defined as Month 6 in the booster vaccination phase This clinical trial was approved by Institutional Review Board (IRB) of Zhejiang Provincial Center for Disease Control and Prevention (approval number: 2021-001-01), and adhered to the Good Clinical Practice (GCP), Declaration of Helsinki, and Chinese regulatory requirements. The protocol was registered at www.chinadrugtrials.org.cn/index.html under the registration number CTR20210426 at 08/03/2021 The vaccine was reconstituted in 0.5 mL of sterile water and then injected intramuscularly into the deltoid muscle of upper arm the participants were vaccinated according to their assigned group (i.e. During the booster vaccination phase (~ 6 months after the primary vaccination) groups B and E received one dose of the booster on day 0 while and groups C and F received two doses of the booster on days 0 and 3 Groups A and D did not receive the booster The presence of a rabies neutralizing antibody response was determined using the rapid fluorescent focus inhibition test (RFFIT) performed by the National Institute for Food and Drug Control (NIFDC; Beijing China); data were reported as geometric mean concentration (GMC) values A GMC of ≥ 0.5 IU/mL was defined as a positive result in this study Immunogenicity was assessed in terms of GMC values the geometric mean 4-fold increase rate (GMFIR) The immune persistence was assessed by the GMC and APR at 6 months after booster and recorded in the Medical Dictionary for Regulatory Activities (version 26.1) The safety was assessed by the incidence of AEs occurring from the first booster dose to 30 days after final dose and the SAEs occurring from the first booster dose to 6 months after final dose The sample size in the primary vaccination was 200 participants per group for groups A and F; the same sample size was used in the booster vaccination phase for groups B Details of the sample size calculation are provided in the Supplementary material (Supplementary page 3) the sample size for evaluating immune persistence in the booster vaccination groups at month 6 was 100 participants per group (half of the sample size of each group) The safety analysis was performed on the booster safety set (bSS) which included participants who received at least one booster The number and proportion of participants who had adverse reactions (ARs) defined as AEs associated with the vaccination (evaluated by professional investigators) after vaccination were reported The immunogenicity analysis was performed on the booster per protocol set (bPPS) which included participants who completed the booster vaccination gave blood samples before and 14 days after the booster The GMC was derived by transforming the antibody titer by log10 The APR was defined as the proportion of the participants who had an antibody titer ≥ 0.5 IU/mL after vaccination The GMFIR was defined as the proportion of participants who were antibody-positive before the booster and had a 4-fold antibody titer rise after the booster The immune persistence analysis was performed on the immune persistence set (IPS) The Student’s t-distribution was used to calculate the 95% confidence interval (CI) from the GMC The Clopper-Pearson method was used to calculate the 95% CI of the APR and GMFIR The Student’s t-test and analysis of variance (ANOVA) were used to analyze continuous data while the Pearson χ2 test and the Fisher’s exact test were used to analyze categorical data The non-inferiority study design was only used in the primary vaccination phase the two-sided alpha value was set to 0.05 in all statistical comparisons USA) was used to perform all statistical analyses Because of the sensitive nature of the personal data generated during this study the dataset is not publicly available; however anonymized data could be obtained from the corresponding author upon reasonable request Rabies Preprint at https://www.who.int/news-room/fact-sheets/detail/rabies Revue Scientifique Et Technique (International Office Epizootics) A randomized open-labeled study to demonstrate the non-inferiority of purified chick-embryo cell rabies vaccine administered in the Zagreb regimen (2-1-1) compared with the Essen regimen in Chinese adults controlled phase III clinical trial to evaluate the immunogenicity and safety of a lyophilized human rabies vaccine (vero cells) in healthy participants aged 10–60 years following Essen and Zagreb vaccination procedures Comparative study on the immunogenicity and safety of a purified chick embryo cell rabies vaccine (PCECV) administered according to two different simulated post exposure intramuscular regimens (Zagreb versus Essen) Immunogenicity and safety of purified chick-embryo cell rabies vaccine under Zagreb 2-1-1 or 5-dose Essen regimen in Chinese children 6 to 17 years old and adults over 50 years: a randomized open-label study Immunogenicity and safety of purified vero cell rabies vaccine (PVRV) produced by Liaoning Cheng Da Co under Zagreb 2-1-1 or 5-dose Essen regimen in Chinese adults aged 50 and above Meta-analysis of immunogenicity and safety of human rabies vaccination under Zagreb and Essen regimens Safety and immunogenicity of human rabies vaccine for the Chinese population after PEP: a systematic review and meta-analysis Rabies Vaccine Information Statement | CDC. Preprint at https://www.cdc.gov/vaccines/hcp/vis/vis-statements/rabies.html (2023) QSMI Guideline for Pos-Exposure Rabies Treatment. Preprint at http://www.ppho.go.th/webppho/dl_strat/F20180507090343.pdf Rabies Prevention and Control Program | Department of Health website. Preprint at https://doh.gov.ph/national-rabies-prevention-and-control-program Evaluating new rabies post-exposure prophylaxis (PEP) regimens or vaccines Long-term immunity and the effect of one or two booster doses with a lyophilized human rabies vaccine (human diploid cells) at 10 years post primary vaccination in China Effect of previous COVID-19 vaccination on humoral immunity 3 months after SARS-CoV-2 omicron infection and booster effect of a fourth COVID-19 vaccination 2 months after SARS-CoV-2 omicron infection and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre Persistence of humoral immunity to rabies 1100 days after immunization and effect of a single booster dose of rabies vaccine Study on the compliance and economic cost of rabies vaccination Persistence of rabies antibody 3 years after postexposure prophylaxis with 2-1-1 regimen of Vero-cell rabies vaccine for human use and antibody response to two booster doses Immune persistence of primary vaccination and immunogenicity and safety of booster vaccination with human rabies vaccine (Vero cell) among 18–50 - year-old exposed individuals Comparison of safety and immunogenicity of PVRV and PCECV immunized in patients with WHO category II animal exposure: a study based on different age groups safety and antibody persistence of a purified vero cell cultured rabies vaccine (Speeda) administered by the Zagreb regimen or Essen regimen in post-exposure subjects immunogenicity of lyophilized purified vero cell cultured rabies vaccine administered in Zagreb and Essen regimen in post-exposure subjects: a post-marketing Investigation on the effects of booster immunization of human diploid cell rabies vaccine after eight years of primary vaccination One-week intramuscular or intradermal pre-exposure prophylaxis with human diploid cell vaccine or Vero cell rabies vaccine followed by simulated post-exposure prophylaxis at one year: a phase III controlled trial to assess immunogenicity and safety Systematic booster after rabies pre-exposure prophylaxis to alleviate rabies antibody monitoring in individuals at risk of occupational exposure Rabies pre-exposure prophylaxis elicits long-lasting immunity in humans Antibody response following pre-exposure immunization against rabies in high-risk professionals Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil Incidence and variables associated with inadequate antibody titers after pre-exposure rabies vaccination among veterinary medical students Using intradermal rabies vaccine to boost immunity in people with low rabies antibody levels Safety comparison of four types of rabies vaccines in patients with WHO category II animal exposure: an observation based on different age groups Safety of post-exposure rabies prophylaxis during pregnancy: a follow-up study from Guangzhou Effect of corticosteroids on RVNA production of a patient with acute disseminated encephalomyelitis following rabies vaccination as well as administration of HRIG Rabies post-exposure prophylaxis for a male with severe Henoch Schönlein purpura following rabies vaccination WHO Expert Consultation on Rabies: WHO TRS N°982. Preprint at https://www.who.int/publications-detail-redirect/WHO-TRS-982 Download references We sincerely thank all the participants and investigators who involved in this study This work was supported by the Key Program of Health Commission of Zhejiang Province/Science Foundation of National Health Commission (grant number: WKJ-ZJ-2221) and Liaoning Chengda Biological Limited by Share Ltd Hua-Kun Lv and Xu Chen contributed equally to this work Zhejiang Provincial Center for Disease Control and Prevention National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Shangyu Center for Disease Control and Prevention Shengzhou Center for Disease Control and Prevention Liaoning Chengda Biological Limited by Share Ltd and Yu Mao contributed to the study design; Huakun Lv, and Yu Mao contributed to the follow-up at the clinical trial site; Xu Chen contributed to the manuscript preparation; Huakun Lv and Yu Mao contributed to manuscript review This clinical trial was approved by Institutional Review Board (IRB) of Zhejiang Provincial Center for Disease Control and Prevention (approval number: 2021-001-01) and adhered to the Good Clinical Practice (GCP) All participants and their guardians (for the participants aged 10–17 years) were fully informed before screening Written informed consent was obtained from the participants (if aged 18–60 years) or the participants (if aged 10–17 years) and their guardians prior to study screening Yan Wang and Yu Mao are the employees of Liaoning Chengda Biological Limited by Share Ltd the other authors had no conflicts of interest to declare Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Below is the link to the electronic supplementary material Download citation DOI: https://doi.org/10.1038/s41598-025-88361-1 Sign up for the Nature Briefing newsletter — what matters in science The devastating COVID-19 pandemic exposed some of society’s most precarious fault lines People who once felt secure – those with stable jobs and reliable safety nets – suddenly faced the harsh reality of vulnerability Once perceived as a distant issue, food insecurity became a lived experience for millions as economic instability, layoffs, and shortages spiraled out of control. Even in the most affluent countries, the cracks became visible. In March 2020, a former refugee, Amine Diare-Conde watched as social service agencies and food banks in his adoptive country of Switzerland were shuttered risking enormous food waste and adding to the 745,000 people already living below the poverty line in one of the world’s most prosperous nations an unprecedented lockdown created drastic shifts in consumer demand and surplus food and other necessities accumulated in warehouses while families went hungry amplifying another existing crisis: food waste Millions of tons of food are lost annually in Switzerland alone and food waste worldwide accounts for a quarter of the environmental impact of the entire food system.                                 As the pandemic wore on, Diare-Conde saw an opportunity to tackle two urgent challenges simultaneously – feeding people in need and reducing food waste. He founded Essen für Alle (EfA) an entirely volunteer-run non-governmental organization (NGO) dedicated to eradicating hunger in Switzerland by redistributing surplus food to anyone who needs it Diare-Conde found an unlikely IT lead in then-thirteen-year-old Matthias Beeler who coded the software that got EfA up and running collecting and distributing food at its first location in Zurich homegrown solution was struggling to keep up with increasingly complex logistics – coordinating the shifts of hundreds of volunteer workers tracking the intake and distribution of thousands of pounds of food and other supplies since EfA’s IT lead was often otherwise occupied with school and homework mobile-optimized solution has streamlined food distribution and volunteer management – enabling the distribution of around 900 tons of food and the management of 10,000 volunteer shifts – while offering 360-degree visibility for planning and oversight and providing advanced analytics to enable further process innovation and optimization Of particular importance to EfA’s clients were the new solution’s stringent protocols for safeguarding sensitive personal data “Many clients come to us asking if we can guarantee that [their] details will be kept securely and I can say we work with SAP so we have everything we need to guarantee secure data handling,” Diare-Conde said By leveraging the SAP BTP AI-enabled business optical character recognition (OCR) capability new clients experience a seamless registration process with a passport scanner that securely captures their personal information while returning clients benefit from a smooth and efficient check-in experience The scalable, cloud-based SAP BTP solution that runs on a database as a service means that EfA’s technology solutions can quickly and efficiently evolve with the organization. “We are constantly working on enhancements and improvements to the existing solution,” Nadjmabadi said. SAP BTP was instrumental in integrating and connecting the entire EfA landscape volunteers from a database that has grown to 1,000 members distribute 20 tons of food to 2,000 people at up to five locations across Switzerland EfA’s impact is even more significant than these numbers suggest because some recipients are collecting food for an entire family meaning that the organization’s dedicated volunteers serve as many as 10,000 people each week demand for EfA’s services will only be increasing 30,223 refugees applied for asylum in Switzerland Diare-Conde plans to keep pace: “We will cover almost all of Switzerland soon.” And the NGO isn’t stopping there – the organization is currently exploring a partnership with a prominent German food bank But given that food waste is estimated to account for 8% to 10% of global greenhouse gases EfA’s impact is already reverberating beyond Switzerland’s borders by directing thousands of tons of food that might otherwise be wasted onto the plates of people in need and by blazing a bold trail that others may follow For the full Essen für Alle episode and the on-demand Better Together: Customer Conversations series, visit sap.com/btp The human side of technology is about ensuring that technology serves people, not vice versa. Known for his thought leadership in intelligent automation and digital transformation, Pascal Bornet said: “It’s about designing and implementing technology with empathy understanding how it impacts individuals and society Doing so enables a future where innovation benefits everyone – ethically Learn more about how Essen für Alle is feeding Switzerland and tackling food waste by the ton: Explore more success stories of customers leveraging SAP BTP to solve a problem innovatively: Timo Elliott is VP and global innovation advocate for SAP BTP at SAP (WAFB) - A 22-year-old man has been arrested in connection with a shooting that happened back in October and left one person with injuries Police said a victim was shot at a gas station located at 5857 Essen Lane on Oct detectives were able to identify Michael Miller as a suspect Miller was arrested and booked into the East Baton Rouge Parish Prison Police said because Miller was uncooperative a motive could not be obtained for the shooting Authorities added Miller has a criminal history which included charges of simple burglary your new go-to podcast to spice up your weekday mornings with relevant news and behind-the-scenes from Brussels and beyond From the economy to the climate and the EU's role in world affairs this talk show sheds light on European affairs and the issues that impact on our daily lives as Europeans Tune in to understand the ins and outs of European politics Dare to imagine the future with business and tech visionaries Deep dive conversations with business leaders Euronews Tech Talks goes beyond discussions to explore the impact of new technologies on our lives the podcast provides valuable insights into the intersection of technology and society Europe's water is under increasing pressure floods are taking their toll on our drinking water Join us on a journey around Europe to see why protecting ecosystems matters and to discover some of the best water solutions an animated explainer series and live debate - find out why Water Matters We give you the latest climate facts from the world’s leading source analyse the trends and explain how our planet is changing We meet the experts on the front line of climate change who explore new strategies to mitigate and adapt A man has been arrested after allegedly setting off two fires in the western German city of Essen that left 30 people injured and driving a van into two shops Emergency services were alerted to two fires in residential buildings in quick succession shortly after 5 p.m The injured people included eight children who were seriously hurt and two of them were in a life-threatening condition after inhaling smoke when it arrived at the scene of the first blaze smoke was billowing from the entrance of the building and people were calling for help from windows Neighbours had put up ladders to help people escape but they weren't long enough to reach the upper floors causing damage to property but no injuries The suspect then allegedly threatened people with weapons but several men managed to push him back with shovels and poles and hold him until police arrived Police said the suspect was a 41-year-old Essen resident with Syrian citizenship They said they were investigating a possible motive the man's lawyer Volker Schröder said he had no political motive and that it was a "purely tragic family story A fight against his wife for the children - and probably a mental disorder." global lifestyle brand MINISO celebrated the grand opening of its first IP collection store in Limbecker Platz shopping center in Essen Germany The store boasts an extensive range of products showcasing a diverse selection for customers featuring a significant collection of popular IPs (intellectual property) zones such as Sanrio with IP-related products accounting for around 70% of the store's offerings The store's interior design also incorporates beloved IP elements to create a whimsical and engaging shopping environment Limbecker Platz is one of Germany's largest and most modern downtown shopping centers As part of the ongoing expansion in Germany MINISO plans to open more stores in key locations across the country bringing its affordable and trendy products to a wider audience the store featured an eye-catching installation of iconic Disney character Mickey Mouse inviting customers to take photos and engage with the brand As MINISO's brand mascot Penpen made appearances at the store and throughout Essen's main streets and the shopping center and handing out gifts to spread joy and excitement The brand also hosted a full day of entertainment including performances by a DJ and dancers energizing the atmosphere and enhancing the festive experience for shoppers the opening day featured promotions such as gift bags and discounts The launch of the Essen store is part of MINISO's broader strategy to expand its presence in Germany with plans to open additional stores in other cities in the near future encompassing prestigious shopping malls such as Centro Oberhausen The brand aims to introduce more high-quality affordable products and sought-after IP collaborations further enhancing its influence in the German market This new store opening marks a significant milestone in MINISO's ongoing expansion of the European market the brand has established over 240 stores across Europe MINISO has also made its mark in iconic locations worldwide steadily building brand recognition among young consumers globally With over 6,800 stores across more than 100 markets globally MINISO continues to make strides toward its mission of "Life is for fun" and its vision to become the world's leading IP design retail group the company remains focused on affordability MINISO has already partnered with nearly 100 IPs worldwide reinforcing its commitment to bringing creative high-quality products to consumers around the globe MINISO Group is a global value retailer offering a variety of trendy lifestyle products featuring IP design The Company serves consumers primarily through its large network of MINISO stores treasure-hunting and engaging shopping experience full of delightful surprises that appeals to all demographics quality and affordability are at the core of every product in MINISO's wide product portfolio and the Company continually and frequently rolls out products with these qualities Since the opening of its first store in China in 2013 the Company has built its flagship brand "MINISO" as a globally recognized retail brand and established a massive store network worldwide Global lifestyle brand MINISO recently released its 2024 ESG (Environment Get ready for the ultimate fluffy party as MINISO's pop-up celebrating Disney's Stitch has come to the U.S Toys Retail Household, Consumer & Cosmetics Household Products Get the best experience and stay connected to your community with our Spectrum News app. Learn More — The historic Essen Haus restaurant and bar and its neighbor the Come Back In will shut down Both are making way for a new housing and hotel development at Wilson and Blair Streets in downtown Madison and you can’t help but feel transported to Germany That’s exactly what owner Bob Worm intended when he opened the business in 1983 “I wanted my customers and myself to have a good time,” Worm said “I wanted a drinking hall like they had in Germany Where there’s a gemütlichkeit type atmosphere where people would come and enjoy themselves.” Gemütlichkeit is a German word to describe the state of feeling warmth That’s what Worm said he was able to foster with Essen Haus as well as the other businesses he bought on the block: the Come Back In and Hotel Ruby Marie “The customers are my favorite part,” Worm said It’s like going to a wedding you weren’t invited to.” from Essen Haus all the way to Come Back In This comes after multiple efforts to redevelop the area over the years have fallen through Pirius is the general manager of Essen Haus and Come Back In.  and we work as a team together and the customers are laughing and dancing we all talk about the shift together and how it was so much fun and the challenges and positives that we went through,” she said City leaders approved a developer’s proposal for a hotel He said it’s hard to say goodbye to the place he’s come to nearly every day for the past 40 years he said he’s grateful for the time he’s been able to spend there and getting into the restaurant business wasn’t any easier Essen Haus and Come Back In will remain open through the summer with a tentative closing date set for early fall Jens Adams rounds out podium ahead of Lander Loockx Laurens Sweeck (Crelan-Corendon) beat Niels Vandeputte (Alpecin-Deceuninck) at the Exact Cross Essen beating his countryman to the line after a tense closing duel The pair led the race on the final lap after breaking away from an elite lead group with Vandeputte leading the way into the last section of the circuit Around the final bend onto the finishing straight Vandeputte slipped momentarily and didn't clip into his pedal quickly enough That gave the opportunity to 30-year-old Sweeck who could come off the wheel on the final straight to speed around and sprint to the win his first cyclocross triumph since the end of the 2022-23 season Jens Adams (Lotto-X Oats-Athletes for Hope) grabbed third place to round out the podium Lander Loockx (TDT-Unibet) in the final dash to the line "I couldn’t really start better than this I think I was a little bit lucky that Niels faltered in that last corner because in principle you can't catch up with Niels there as he's also fast The wind played a role in the longer stretches at the beginning of the circuit There was always a bit of a jostling towards the forest I was able to keep myself in a good position throughout the race "This is a very important victory for me because it has been a long time since I won." The major separation in the race came in the third lap of 11 as Toon Aerts (Deschacht-Hens-FSP) pushed a high pace at the front His acceleration split the front group to leave seven men in the lead Loockx and Aerts as well as Corne van Kessel (Deschacht-Hens-FSP) and Toon Vandebosch (Crelan-Corendon) leaving a large lead group at the head of the race at the midway point though Aerts lost 20 seconds and was forced to chase after suffering a problem with his chain The final laps saw both Aerts and Ward Huybs (Baloise Trek Lions) making their way to the front the pair getting there to make it eight up front on lap eight That situation stuck into the final lap of the race it was Loockx and Huybs who kicked things off with high-pace efforts as Sweeck also attempted to push on Sweeck ended up provoking the winning split as he broke away at the front to fight a two-man contest for the race win who finished third at the Exact Cross in Beringen last week was forced to settle for another podium spot Results powered by FirstCycling Dani has reported from the world's top races She has interviewed many of the sport's biggest stars and her favourite races are the Giro d'Italia BATON ROUGE — The eastbound Interstate 10 exit at Essen Lane is closed as crews move an overturned semi-truck carrying 50,000 pounds of flour that caused a multi-car collision.  on Monday and caused several other vehicles to crash as a result Seven people were transported in stable condition by Baton Rouge EMS.  The road closure on Monday lasted more than two hours BATON ROUGE — Deputies are searching for a woman who stole a car while its owner was inside a RaceTrac on Essen Lane East Baton Rouge Parish deputies said that the owner of the Honda Fit left the car running while inside the gas station's convenience store on March 23 Deputies said the theft victim saw a woman enter the car and drive away The car was found abandoned on Interstate 10 near College Drive Deputies ask anyone who knows anything about the theft or can identify the thief to call EBRSO's auto theft division at 225-389-5064 a firm that works on newspaper mergers and acquisitions Owen Van Essen is wrapping up a long career in the newspaper industry primarily for merger and acquisition firm Dirks Owen Van Essen remembers the early days when he first got into newspapers working at a small daily in Minnesota on the business side That work eventually transformed into an ownership stake of the small daily which he held onto for nine years in the late 1970s and early- to mid-1980s “One of the two brothers who owned the newspaper convinced me to stay a year while he took a one-year sabbatical,” Van Essen said “It gave me an opportunity to really get immersed in the business as somebody quite young.” as the kickstarter to what has turned into a decadeslong career in the newspaper industry The family and Van Essen just a few years later sold their ownership stakes and Van Essen found new life in the side of the business that worked on the industry’s many mergers and acquisitions Representing the sale of Van Essen’s stake in the newspaper was Lee Dirks a well-known newspaper merger and acquisition firm based in Santa Fe joined Dirks the same year he sold off his stake in 1986 and in the years since has helped the firm represent about half the country’s daily newspaper transactions Van Essen sat down with The New Mexican to discuss his career the future of newspapers and what his plans are with more free time on his hands This interview has been edited and condensed for clarity Question: You mentioned you worked on the business side of newspapers Was journalism a thing for you as a kid growing up Answer: I loved the media business as a youngster I rapidly gained an appreciation for what the newsroom does once I started at this newspaper kind of regarded as maybe the best small daily newspaper in the state of Minnesota and with some really talented journalists working there It was a place where the family that owned the newspaper recognized that if they got really high-caliber talent they would lose it eventually to a bigger paper [it] developed this reputation within the journalism schools as a very good starting job and the newspaper was able to secure the services of some really talented people for three to five years and then they would move on to bigger and better things Question: So you had an ownership stake in the Worthington Daily Globe for a number of years Then you join Lee Dirks at his firm that works on newspaper mergers and acquisitions Answer: I like to remind my former colleague Lee Dirks that I hired him before he hired me I was fortunate enough to get involved in the ownership of a daily newspaper in Minnesota I really wasn’t sure what I was going to do after we sold the newspaper but I loved the industry and wanted to travel You can continue to work in this space.’ I’d never really envisioned this to be a lifetime career most of the time on the sell side of a transaction So we’re engaged to sell a newspaper when a company wants to sell it we worked predominantly for independent owners who are getting out of the business We now work just as often for large groups of newspapers that want to sell off some of their papers for one reason or another The first thing we do is we analyze the operation and identify the strengths and weaknesses — the selling points of the firm is that everybody who’s worked there — all the principals who work there — has worked in the business than the Wall Street folks who would be our competitors but they just don’t understand the business The other thing they don’t understand is how the business is tied to the community in which it’s published And so I think we do a very good job of developing that story representing somebody who is buying a paper we’re able to assist them in analyzing the strengths and the weaknesses and community acceptance of a particular newspaper Question: What was that transition like for you as someone who owned a paper and then became a partner in a firm that represented newspaper mergers and acquisitions I had a very good partner who could teach me the part of the business that I wasn’t familiar with and could talk that business with our clients and with prospective buyers I think one of the strengths of our firm is that we had so many long-term people Lee Dirks was in the business for 25 years who just retired and was with the firm for 25 years has already been with it for about 20 years we developed these relationships with the industry folks We know who the owners of these newspapers are; we know their strategies so that they share with us kind of their strategies Question: Is there any deal that you’ve worked on that stands out to you Answer: It happens to be the largest deal we did There was a company back in the ‘90s and they exited the business in 2000 — a company called Thomson Newspapers They were a Canadian-based company but the largest publisher of daily newspapers in the United States And for strategic reasons decided to get out of this business which did manuals for attorneys and so forth They had a lot of newspapers to sell and the total aggregate value of that transaction was $2.2 billion Part of the strategy was carving up that package of newspapers that was spread all across the country into packages that made sense for prospective buyers and then making sure at the end of the process you didn’t have any orphans But that’s the one I think that stands out for different reasons but clearly one of those reasons is it’s the largest transaction But your firm recently was involved in the sale of Gannett newspapers in New Mexico (The Farmington Daily Times Did you have any involvement yourself in those transactions Answer: I’ve worked very closely with Gannett for decades What they’re doing is their current business strategy is geared to their big papers in Phoenix and Milwaukee They’re smart enough to recognize that there’s no way they should run these smaller papers like they run those papers And so their goal is not to do that and to put them into the hands of people who are local for the most part and who operate newspapers in quite different fashion than from how they operate those big newspapers I think we’ve maybe done 20 transactions or so involved in Gannett as a seller we sold off seven or eight of their papers in Missouri similar to what’s happened in New Mexico just recently Question: Is that a normal occurrence — working with a company like Gannett and then selling typically to local folks like in this case El Rito Media and Ballantine Communications because you can take advantage of economies of scale if you publish a number of newspapers in a region It makes good sense that the business is going in that direction That’s been going on for quite some time actually — some people call it clustering Owning a group of papers in the same region affords you a lot of expense synergies Question: I’d say that you’re heavily involved in the newspaper business even if it’s from the perspective of helping folks sell their newspapers As someone who’s been in this business for decades what do you think the future holds for newspapers the smallest of the papers — the small weekly newspapers in towns of 1,000 people or less — might be endangered species It’s going to be difficult for them to continue to publish They’ll all have to go to a digital delivery [to survive] The need for local news is always going to be there I think having professional journalists produce that news is always gonna be around newspapers in towns the size of Santa Fe are the sweet spots [Newspapers] might publish on fewer days of the week What does that look like and when did it start Answer: Sara April has been a wonderful partner and we’ve gradually transitioned more and more of the workload to her And so really [retirement] started this spring in earnest where I’ve decided not to sort of quarterback any particular transaction I’m still deeply involved with long-term clients and so I do some [mergers and acquisitions] work every week and I sort of think that it’s going to continue at least for this year or next I have this incredible conviction about the importance of newspapers in communities As I probably have a little more time to do other things some of those things might be involved with efforts to work with [local publishers] in developing legislation that would be helpful to the industry Answer: I’d like to become a much better golfer than I am There’s a bunch of things that I’ve not really had the time for in the past My wife and I have started to spend some time in Arizona during the cold months here … I’m sure I will be able to find things to do A business degree from Dordt University; also did advanced work in business and journalism at the University of Minnesota Keep up with what's going on in the local business scene Get up-to-the-minute news sent straight to your device Account 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how to reset your password has been sent to the email address listed on your account It feels strange kicking off my 2024 Essen Motor Show coverage with a spotlight you need to take a break from the madness of a huge event like this one I’ve retreated to the media suite upstairs to recharge And what better way to do that than by telling you about my two all-time favourite cars ever built in America For those still getting a sense of my automotive tastes, let me lay it out: my dream three-car garage consists of my very own BMW 740i Sport My BMW is a non-negotiable in the garage, while the 964 only just wins out against the 993 Cup 3.8 RSR. The Shelby That could easily be replaced by a split-window 1963 Chevrolet Corvette Stingray imagine my shock when I turned a corner at EMS and found a matching GT500 and Stingray parked side by side on the V8 Werk stand in Hall 7 at Messe Essen wondering if I’d fallen into a fever dream these cars are as rare as they come in the world of ’60s American sports and muscle cars with a desirability factor that’s through the roof The split-window C2 Corvette was only available in 1963 thanks to Bill Mitchell’s design direction it’s one of the most iconic shapes in automotive history taking inspiration from the outlandish spine of the Bugatti Type 57 and refining it into the sleek it was a world apart from the more traditional 1962 Corvette roadster it replaced the C2 felt like it had been designed in another century The dashboard featured two large arches housing the instruments for the driver along with a lockable glovebox for the passenger The Corvette was no longer a silly little summer weekend toy; it had evolved into a car you could comfortably use every day it wasn’t just about looks and comfort – it was still a serious performance car for the time producing between 350 and 360hp depending on your budget and how badly you needed to win those traffic light drag races against your neighbours and lighter body meant the Stingray weighed less than the roadster that came before it and handle far better than its predecessor I can’t help but be drawn to the bruteness of the Shelby GT500 After nearly two years of the GT350 – Carroll Shelby’s race-focused lightweight masterpiece – he and the team at Shelby American decided to take bigger steps to differentiate their cars from Ford’s typical Mustang One of the most noticeable changes was the car’s bodywork more aggressive fibreglass nose cone and a Kamm tail rear fascia with an integrated spoiler The front grille housed a pair of central spot lamps and the iconic three-bar taillights were swapped for much wider items borrowed from the Mercury Cougar replaced by functional ducted scoops and lower brake cooling scoops The fibreglass hood was now fitted with a scoop to improve engine cooling and airflow because with the 428ci (7.0L) ‘Police Interceptor’ V8 crammed under that bonnet churned out around 360hp and 420ft/lbs of torque While the GT500 might sound like the more brutish of the two the truth is it was much tamer than the GT350 was sometimes considered too rough and aggressive for regular driving ironed out some of those rough edges by dropping the more highly-strung V8 and limited-slip differential in the back As much as the boy racer in me yearns for a ’67 GT350 – ready to take more abuse but with the gorgeous Shelby-designed nose and tail – the reality is that with GT350s and GT500s selling for well over US$200,000 these days I’d probably be terrified to truly explore their full potential So maybe the GT500 would make more sense – a perfect balance of power I had the privilege of experiencing not one but both of these dream machines at the same time who poured thousands of hours into restoring each car for the same owner How could I possibly resist an invitation to visit their workshop and showroom I might be too busy pinching myself to take any photos Now that's what you call an American classic nothing like the Mustang and Corvette Sara Casasola and Laura Verdonschot round out podium Marion Norbert Riberolle (Crelan-Corendon) scored her first win of the 2024-25 cyclocross season at the Exact Cross in Essen soloing home just as she did in last year's edition of the race The Belgian got away from a select lead group on the sixth of seven laps in the race having earlier tried to make a winning move on the fourth lap She left behind Italian teammate Sara Casasola with Casasola coming through to take second at the line Laura Verdonschot (De Ceuster-Bouwpunt) rounded out the podium at 11 seconds down The Belgian had been the only rider to stick with Norbert Riberolle two laps earlier while Casasola and another De Ceuster-Bouwpunt rider "My mother usually comes to races but not this time They watched my win on TV so I'm very happy "Last year I only took my first win in December and now it's at the beginning of the season She's a good teammate so yes it was super nice." Lap five saw several Dutch riders make it across the gap to fill out the lead group Aniek van Alphen (Cyclocross Reds) and Manon Bakker (Crelan-Corendon) were among the riders who linked up with the lead trio rather than making any attacking moves for themselves it was up to Norbert Riberolle to make the decisive jump Casasola and Franck led the chase behind as the Italian looked to take the initiative bringing the pair close to the sole leader Norbert Riberolle had too much in the tank for her chasing rivals she enjoyed a 21-second lead over the rest enough for her to survive comfortably and score the victory coming out from behind Franck to push on alone and take second place BATON ROUGE — One is dead and one is injured after a car crash on I-10 West at Essen Lane Officials say Templet was driving a Nissan and lost control of her vehicle her vehicle rolled onto its side where she was partially ejected.  Detectives say Templet was not wearing her seatbelt.  The driver of the Mercedes was transported to a local hospital with moderate injuries but officials say the other two passengers were uninjured.