Lauren Heinsch named UNI’s first-ever CSC Academic All-American in soccer12/11/2024 11:00:00 AM | Women's Soccer Panthers’ all-time leading scorer among 33 selected to elite academic honor GREENWOOD, Ind. --- UNI senior soccer forward Lauren Heinsch received a prestigious academic honor on Wednesday morning as she was named to the College Sports Communicators (CSC) Academic All-America Second Team which this year was given to 33 total student-athletes in Division I among three different teams is among the highest academic honors for collegiate athletes who finished her fifth and final season with the Panthers this season is the first player in the 25-year history of the UNI soccer program to receive the honor holds a 3.99 cumulative grade-point average (GPA) and is majoring in biology chemistry and pre-professional medicine at UNI She also earned CSC Academic All-District honors this season students must be at least a sophomore both academically and athletically must have at least a 3.50 cumulative GPA on a 4.0 scale and participate in at least 90% or start in at least 66% of their team's matches Heinsch led the 2024 Panthers with eight goals scored plus one assist for 17 points in UNI's 25th anniversary season The only player to earn three First Team All-Missouri Valley Conference (MVC) selection in her career Heinsch set multiple career program records in her final collegiate season matches played (86) and matches started (86) Heinsch is also a three-time MVC Scholar-Athlete First Team selection (2022-24) and was named the league's Scholar-Athlete of the Year in 2022 The Panthers finished the 2024 season with a 9-6-4 record, tying for fifth in the MVC standings after posting a 4-3-3 record in league play. UNI qualified for the MVC Tournament for the seventh time in eight seasons under head coach Bruce Erickson falling to Illinois State in the opening round From its founding in 1957 until the 2022 name change the organization was known as College Sports Information Directors of America (CoSIDA) UNI women's soccer action can be followed all season long on social media on Facebook (UNI Panther Soccer), X (@UNI_Soccer) and on Instagram (@unipanthersoccer) along with the latest Panther news and information can be found online at UNIpanthers.com Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page the Kalshoven-Gieskes Forum (KGF) and the Grotius Centre for International Legal Studies had the pleasure of hosting an inspiring authors’ workshop in The Hague for the forthcoming Research Handbook Victims' Rights under Public International Law edited by Dr Robert Heinsch and Dr Jelena Plamenac Gathering a diverse group of contributors from across the globe the workshop served as a platform to share and harmonise the ideas behind each of the chapters The atmosphere was one of dynamic collaboration with each participant bringing unique expertise and insights on how this book could become a vital resource for advancing victims’ rights under international law The first day began with an exploration of the historical and structural roots of victims' rights diving into complex questions about barriers to justice and how different areas of international law - specifically International Humanitarian Law International Human Rights Law and International Criminal Law - can intersect to support victims more effectively Participants discussed frameworks for addressing the challenges of business-related human rights abuses and the often-overlooked impacts of armed conflicts These discussions shed light on the current gaps in protections and highlighted the emerging strategies to close these gaps the focus was on accountability mechanisms and the critical role of legal bodies in advancing justice for victims Topics included the complex advocacy process for victims in ICC proceedings protective measures for vulnerable witnesses and the unique challenges faced by victims of forced displacement The closing sessions examined reparations models and how national and regional courts can provide remedies for human rights violations These thoughtful discussions have not only helped shape the book’s direction but also underscored its potential to provide practical actionable guidance for those working to support victims The workshop was both impactful and inspiring, made possible by each contributor’s invaluable insights, passion, and commitment to shaping this book into an essential resource for victim-centred international law. The workshop was sponsored by the Leiden University Fund/Dr H.A. van Beuningen Fonds, www.luf.nl Exploring the Frontiers of International Law PERSONAL: Daughter of Larry and Shelli Heinsch .. Hobbies include spending time with her friends and water sports on the lake Sports by | May 2020 Bats cracking and fans cheering will soon become commonplace sounds at the Excelsior Commons fields the men’s and women’s South Shore Softball Leagues kick off another season of a beloved American pastime on the picturesque shore of Lake Minnetonka which sprouted from a men’s church league back in the day Some teams have seen family dynasties play the same field According to league manager Molly Bahneman “A lot of the women went to high school together They played ball together when they were in school Some of their moms were or are on the team.” she started playing in the league at the age of 18 and she’s hit the field every summer since “She grew up just sitting on the bench,” says Heinsch but she’s playing the sport now and often says But just because the league is steeped in longstanding tradition doesn’t mean they aren’t on the lookout for new blood “I really try to reach out to new players,” says Heinsch “I found someone at Early Childhood Family Education who had a softball shirt on Support from the community in recent years has also added to the fun The city of Excelsior has “been doing a lot in the park to get music and food trucks,” notes Bahneman Many residents bring their kids when they come to cheer on the games because of the nearby park And for the past few summers on Wednesday evenings Excelsior Concerts in the Commons have “drawn a lot of people to come watch the softball games and that’s really fun,” Heinsch says “The part that I think I found so interesting was the long-standing relationship that the players have with each other and the teams and how it was such a special part of their summer.” She also appreciates how much people love playing on the fields of Excelsior Commons I like the scenery—it’s on the lake and just beautiful I like my teammates and the thrill of competition Sign up for our newsletter and receive email updates with our top stories , , , , © Copyright 2026 Local. All Rights Reserved | Privacy Policy Read the May 2025 Lake Minnetonka Magazine Digital Edition            Heather Flies watched her five older siblings leave their southern Minnesota town to attend Bethel University she discovered the heart God gave her for young people Now she has her Master of Arts in Theological Studies from Bethel Seminary and is in full-time junior high ministry at Wooddale Church junior high pastor at Wooddale Church and Bethel Seminary Alumna of the Year she transferred from a private school to a public school she welcomed the opportunity for new friends—but rather than being welcomed herself she was met with bullying because of her weight Having been raised in an uplifting family that celebrated who she was Flies found herself caught in a battle over what to believe “It took quite a bit of wrestling to get to the point where I believed that I was someone made on purpose and with purpose,” she says Flies is nearing her 22nd year of service as junior high pastor at Wooddale Church in Eden Prairie helping students discover who God created them to be and affirming them along the way “It’s a passion of mine to allow kids to be who they are no matter how different it is,” Flies says “And it’s also a passion of mine to be an example of somebody who loves who God created her to be so that kids have the freedom to do the same thing.” Flies was raised in southern Minnesota by her stay-at-home mother and her father she remembers her oldest brother Greg venturing off to attend Bethel University she followed in his—and the rest of her siblings'—footsteps becoming the sixth Heinsch to attend Bethel “I started my communication degree at Bethel because I wanted to work in the public relations department for the Minnesota Vikings and have big babies,” Flies says with a laugh “But God had a different plan.” Flies spent her summers working at Trout Lake Camps in Pine River which is where she says the Lord began to develop her heart for junior high ministry Of the nine weeks Flies spent at Trout Lake Camps each summer Flies was certain of her call to youth ministry Knowing strong communication skills would be foundational layering her years at Bethel with experience with young people Flies began working at Wooddale Church and has been in the same role since which includes creating and implementing Sunday and Wednesday programming teaching the 9th grade spiritual formation class and all other tasks required for fruitful service to students and their families Flies enrolled in Bethel Seminary to earn her Master of Arts in Theological Studies “I wanted to be a better junior high pastor because I believe junior highers deserve someone who is knowledgeable…” Flies says “And that’s exactly what happened—through study of the Word I learned how to be a better junior high pastor.” “I think the biggest thing is that I honestly believe I am doing what God crafted me to do While Flies has had opportunities to move into different types of ministry she’s chosen to continue devoting her time and energy to junior high students “I believe this is what I’m supposed to be doing,” she says “I have fought to stay in the game and on the front lines with junior highers because I believe they are capable of so much more than people give them credit for."  Flies’s long-term commitment to junior high students at Wooddale has allowed her to see the impact of her ministry and helped her maintain relationships with her former students She’s watched them graduate from high school She’s seen kids grow in ways the rest of the world never expected Flies tells the story of a student who was cared for by a foster family at Wooddale This student demonstrated difficult and sporadic behavior in both school and church “I remember leaning into that relationship calling out what I saw in him and how I believed God was working in his life,” she says Years later at this student’s high school graduation party they stood locked in a hug with tears flowing from their eyes ‘I remember what you were like when you were 10 and I look at you now and I am so grateful for what God has done,’” Flies says “I would have missed that if I would have left the junior high ministry.”   Beyond the sweetness that comes with watching her students grow Flies credits the longevity of her service to the joy of the Holy Spirit and her high capacity for social interaction She also has her support system at home: her husband Chad whom she met when he volunteered with the junior high ministry Bethel honors three outstanding alumni who are making a difference in their communities If you know an incredible alum who deserves to be recognized Nominations are accepted year-round and remain in consideration for 3 years Learn more Support Bethel © 2025 Bethel University | CA Student Disclosures | Privacy Policy Bethel University’s Christ-centered mission includes a commitment to equal educational opportunity and equal employment opportunity Bethel does not unlawfully discriminate on the basis of race Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInBISMARCK N.D (Dakota News Now) - The Augustana baseball team finished a four-game set against UMary on a high note sweeping on Sunday afternoon to take the series at Bismarck Municipal Ballpark The Vikings jump to 19-10 overall and 14-6 in the NSIC while the Marauders fall to 13-16 Carter Heinsch went 2 for 3 and stole three bases in his first multi-hit game while Ragan Pinnow had a pair of doubles and scored three times in the game one victory The Vikings had seven hits and drew six walks while Jack Hines also drew a HBP and drove in two runs. Trevor Winterstein also drove in a pair while scoring twice Ethan Cole struck out seven in six scoreless innings while allowing just four hits to earn his third win of the season. In the final frame, Jadon Bast tallied a strikeout while throwing just seven pitches to close the win The game was scoreless until the Vikings broke through in the third inning. Ragan Pinnow hit a leadoff double to left and reached third on a one-out, infield single from Trevor Winterstein Bjorn Lind walked to load the bases and Jack Hines lifted a sac fly to bring home Pinnow and give AU a 1-0 lead A wild pitch brought home Winterstein to double the lead and Jason Axelberg drew a walk to get a pair on. Three pitches later, Nate Soelter smashed one off the left field wall for a double driving in Lind and Axelberg and putting the Vikings ahead 4-0 After Cole sent the Marauders down in order to close the third, the bats kept the scoring going in the fourth. Carter Heinsch singled and stole second to lead off the inning and Pinnow hit his second double of the game to left Pinnow moved to third on a failed pickoff attempt and would score on a Winterstein sac fly to make it 6-0 AU Four more runs crossed the plate for the Vikings to put the game out of reach Pinnow walked and both runners stole to get two in scoring position After a Kobe Eikmeier walk loaded the bases Winterstein rolled one through the legs of the shortstop scoring a pair and putting AU in front 8-0 Winterstein would steal second on the next pitch and Eikmeier scored as the throw got away The final run came off the bat of Hines as UMary committed its fifth error of the day and allowed Winterstein to score on the play Heinsch continued his special day with three hits three runs scored and two stolen bases to power the offense Winterstein also had three of each and was a home run short of the cycle while Soelter joined them with three hits and three runs scored Pinnow had a double while knocking three hits Adam Diedrich recorded a pair of outs to open the game, his first action since March 30, 2024. Kai Taylor entered in the first inning and went 4 ⅓ scoreless innings while allowing three hits and striking out one Aidan Torpey, Maddox Foss, Joel Van De Stroet and Ryan Clementi combined to throw the final three innings with Clementi striking out the side to finish it Winterstein led off the game with a triple and scored on a Lind groundout to open the scoring The Marauders responded in the bottom of the first with a three-run inning for the lead Soelter led off the second with a single before a failed pickoff attempt moved him to second He would come around to score on a Heinsch single to cut the deficit to one Heinsch moved to second on a wild pitch and a Pinnow infield single put the pair on before Koskie was hit by a pitch to load the bases Jake Lundquist got a job done with an RBI groundout to score Heinsch and then Winterstein smacked a double to right to score Koskie and Pinnow Axelberg rounded out the second inning scoring with a two-out bunt single to bring in Hines and make it 6-3 AU stole second and advanced to third on a wild pitch before a Pinnow infield single brought him home to make it 7-3 Hines led off the fourth inning with a double and was able to score on a one-out triple by Nate Soelter to right field Heinsch lifted a sac fly in the next plate appearance to grow the Viking lead to 9-3 The scoring picked back up in the sixth. Lind wore a pitch to lead off the inning and Jack Hines singled through the left side right after. They each advanced on a failed pickoff and Lind scored on an Axelberg sac fly. Three pitches later, Soelter singled to center to bring Hines home and, on the very next pitch, Heinsch doubled down the line to drive in Soelter. After stealing third, Heinsch came home on an RBI groundout from Pinnow to bring the lead to double digits at 13-3. In the bottom of the sixth, the Marauders scored a run to get back within single digits. Hines lifted a sac fly to score Winterstein in the top of the seventh but three UMary runs in the bottom of the frame kept the game moving with the score 14-7 AU. Pinnow continued his strong day with a leadoff double in the eighth. Berg followed with a walk and they each stole a base to get into scoring position. Pinnow was able to score on a wild pitch and Berg came around on a Winterstein RBI groundout to add a pair of runs. The Vikings got back ahead by double digits when Lind wheeled all the way around from first on a throwing error by the pitcher to bring the game to its final score. The Vikings play in the Birdcage on Wednesday afternoon, taking on Sioux Falls for a doubleheader starting at 4 p.m. Copyright 2025 Dakota News Now. All rights reserved. Queen of the Apostles Parish held its May Crowning of the Blessed Mother following the 10 a.m. Mass on Sunday, May 5, at the church, 715 Hawthrone St., Avoca. The Rev. Joseph Sibliano, OSJ, and Deacon Jim Rose led the prayerful service. Volume 9 - 2018 | https://doi.org/10.3389/fmicb.2018.00313 This article is part of the Research TopicNovel Metabolic Engineering Approaches for Producing Novel ChemicalsView all 21 articles Increasing the final titer of a multi-gene metabolic pathway can be viewed as a multivariate optimization problem While numerous multivariate optimization algorithms exist few are specifically designed to accommodate the constraints posed by genetic engineering workflows We present a strategy for optimizing expression levels across an arbitrary number of genes that requires few design-build-test iterations We compare the performance of several optimization algorithms on a series of simulated expression landscapes We show that optimal experimental design parameters depend on the degree of landscape ruggedness This work provides a theoretical framework for designing and executing numerical optimization on multi-gene systems Select optimization strategies for multi-gene biological systems Fitness landscape analyses performed on a library of nitrogen fixation gene clusters suggests that complex multi-gene systems can be moderately rugged and will not lend themselves to linear regression (Smanski methods that seek to optimize the efficiency of function evaluations do not distinguish between the number of iterations and the number of function evaluations per iteration This distinction is important for genetic engineering projects Increasing the throughput of a single design-build-test cycle can typically be done at a small fraction of the cost compared to increasing the number of design-build-test cycle iterations we describe and model an approach to genetic optimization that combines (i) the quantification of fitness landscape ruggedness with (ii) a high-throughput low-iteration optimization algorithm for improving genetic design We show that the optimization parameters should be tailored for each system based on fitness landscape ruggedness we compare the performance of this approach to several alternative hill-climbing algorithms (A) Three model landscapes described in the text as ‘smooth’ (left) and ‘rugged’ (right) are shown as three-dimensional wire surfaces (top) and two-dimensional contour maps (bottom) X- and Y-axes represent hypothetical expression levels of two genes in a multi-gene system (B) Autocorrelation function plotted for smooth (white circles) and rugged (black circles) landscapes compared to hypothetical traces based on NK-model Forty thousand coordinate (X,Y) points were sampled from each model landscape in a square-grid pattern (200 × 200 points) and evaluated to determine the Z-value at each location For all possible pairwise combination of points two values were recorded: (i) the Euclidian distance between the pairs of points in the X–Y plane and (ii) the squared difference between the two Z-values all pairwise comparisons were binned based on Euclidian distance into bins from 0–100 The average variance for each bin was calculated by taking the mean of the squared differences for pairs of points in that bin For the landscape autocorrelation analysis (LAA) where σ2landscape is the random variance for the landscape This was approximated using the pairs of points for which the Euclidian distance is between 600 and 700 as distances greater than 700 are constrained by the size of the search space (1000 × 1000 grid) leading to less pairs sampled at greater distances Landscape ruggedness was quantified by plotting lines from the function: for N = 700 and determining the best-fit value of k by the non-linear least squares method in R (Version 3.3.3, R Core Team, 2017) the center point is generated as described for the basic algorithm but the subsequent quasi-random sampling is perturbed to preference sampling in the same direction as the vector connecting the previous center point to the next center point We began by creating three model landscapes for testing optimization algorithms (Figure 2A) The 3D landscapes simulate a two-gene system where the X- and Y-dimensions represent the expression levels of the two genes and the Z-dimension represents the measured performance of the system (e.g. Most metabolic pathways are more complex than this but we chose to model a two-gene system because the progress and results of the algorithm are easily visualized The algorithms described in this study can be easily adapted to higher-dimensional space We next developed a set of numerical optimization algorithms that are designed with the technical aspects of metabolic engineering in mind the algorithms search the multivariate expression space with very large sampling libraries a 20-gene synthetic nitrogen fixation pathway was recently improved using five iterations each with approximately 100 alternative genetic designs the area of the multidimensional expression space sampled and the fraction of sampled points carried forward as parents for the next iteration we sample a defined area using Sobol sequences Sobol sequences provide a quasi-random distribution of a search space and provide more even coverage of the space than a random Gaussian sampling Illustration of optimization algorithms used in this study (A) Illustration and table of parameters in Sobol Hill Climbing algorithm The vector and dashed circle denote the spread of sample points (σ) from the starting coordinates (SC) Gray and black dots show the sampled points per iteration (N) Black dots represent the fraction of points selected as parents for the next generation (F) Parameters are listed in the table with approximate ranges of parameter values explored in the current study (B) Top panels show results from a single simulation experiment with the following parameter values: L = smooth; SC = [300,700]; σ = x; N = xx; I = 5; F = 0.x Each iteration is shown from left to right Bottom panel shows the route taken by the optimization algorithm with black line tracing location of center-points for Sobol sampling Insets show increase of fitness (z-axis) through each iteration (C) Summaries of triplicate simulations on three distinct parameter sets Graphs represent optimization routes as described in (B) with triplicate simulations represented as black Parameters are given below each graph in the format of [L; SC; σ; N; I; F] This algorithm differs from Sobol Hill Climbing in two important ways the center point for the next iteration is determined by the weighted average of the high-fitness parent points the shape of the sampling space is adjusted with each iteration While the first two algorithms always search with a Sobol sequence following an N-dimensional standard normal distribution the CMA-ES algorithm adjusts both the size and shape of the sampled area according to the size and shape of the distribution of high-fitness parent points We evaluate the performance of an algorithm by tracking the fitness of the center point for each of the first five iterations (Figure 3C) The area under this curve represents the performance of the algorithm the performance reflects both the fitness value attained and how quickly the algorithm arrived at that fitness value We run each algorithm five times with identical parameters and record the standard deviation of the performance metric This gives a measure for how reliably the algorithm can be expected to perform Parameters such as number of points sampled per iteration or the number of iterations are likely to be determined by the time and resources available for expression optimization efforts Parameters affecting the distribution of sampled points and the fraction of sampled points used as parents for the next iteration do not change the cost of a given design-build-test iteration but can greatly influence the optimization results We simulated each optimization algorithm using a range of parameter values for σ and F we simulated five optimizations and score both the average fitness and the standard deviation as measures of performance and reliability the algorithm was less reliable at values of F < 0.2 This was not observed for the smoothest landscape Performance and reliability of numerical optimization algorithms across parameter space left plots show mean performance from five independent simulations at each parameter combination for optimizations run on a smooth landscape (top) Right plots show reliability of algorithm for each parameter combination measured as the standard deviation of performance over the five independent simulations The Sobol Projection algorithm (Figure 4B) performed slightly better that the Sobol Hill Climbing method this algorithm was more sensitive to the fraction of kept values (F) Low F-values resulted in a substantial decrease in fitness as well as an increase in noise Both the Sobol Projection and Sobol Hill Climbing algorithms showed a prominent loss of reliability (high standard deviation) on the medium-ruggedness landscape when the sampling range was approximately 100 units the optimization algorithm tended to get trapped in one local optimum which was determined stochastically at an early iteration The CMA-ES optimization strategy (Figure 4C) performed substantially worse than the others in the conditions tested both in terms of fitness values attained and in the reliability It routinely found the global maximum in the smoothest landscape but not as quickly as the other two algorithms it rarely found the global maximum in the first five iterations When the CMA-ES algorithm was allowed to run for more iterations it routinely found the global maximum (data not shown) Apparent ruggedness caused by genetic context effects will diminish the efficacy of linear regression and other methods that assume a smooth landscape Whether the ruggedness of a gene expression landscape comes from interactions of gene products or genetic context effects that produce a lot of noise when sampling a multidimensional expression space the impact on optimization strategies is similar The global optimum on smooth landscapes can be found through conservative searches that continuously walk uphill Rough landscapes require a less conservative approach where a fraction of the sampling resources are used to search for other local maxima We have presented a set of analyses that first assess landscape ruggedness and then optimize the landscape using a limited number of high-throughput iterations We show that landscape ruggedness affects optimal parameter settings during a multigene optimization strategy As the landscape topology is a characteristic of the system being optimized it will not be tunable (as it was with our model landscapes) knowledge of the ruggedness can guide the engineer to select appropriate parameters values such as the sampling range and the fraction of sampled points used to guide the next iteration Smooth landscapes tolerate optimization strategies that cast a broad net over the sampling space and use information from only a small number of sampled points to direct the next round of sampling optimization of more rugged landscapes benefits both in terms of performance and reliability from sampling less broadly and using information from roughly 40% of the sampled space to direct the next round of sampling We did not assess whether the benefit of improved optimization parameters outweighs the cost of performing an initial sampling of variable space to quantify ruggedness Such a cost/benefit analysis would be highly specific to the system being optimized Landscape ruggedness assessments are likely only valid in the local neighborhood of variable space. Rugged fitness landscapes can appear smooth across small search spaces, and empirically derived fitness landscapes tend to be asymmetric (DeWitt and Yoshimura, 1998) it is important to reassess local ruggedness in optimizations that drift far from the original starting point While not included in the models tested here it would be useful to continuously update the ruggedness quantification with each round of sampling This could be done using points sampled during optimization efforts and would not require any additional experimental steps We propose an integrated strategy for metabolic pathway engineering that combines landscape analysis with a multivariate optimization algorithm An initial autocorrelation analysis provides a quantitative measure of the ruggedness of the adaptive landscape This ruggedness metric is used to guide an appropriate selection of parameters during the iterative optimization process Of the three optimization strategies simulated in this study the Sobol Projection method gave the best performance on several model landscapes Further work is needed to validate this strategy using an experimental system and MS designed the experiments and performed the analyses The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest We would like to thank Christian Müller from the Simons Center for Data Analysis and helpful discussions The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2018.00313/full#supplementary-material Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces Multivariate modular metabolic engineering for pathway and strain optimization Antisense transcription as a tool to tune gene expression Contextualizing context for synthetic biology - identifying causes of failure of synthetic biological systems Engineering biological systems using automated biofoundries The fitness threshold model: random environmental change alters adaptive landscapes CrossRef Full Text | Google Scholar Complete motif analysis of sequence requirements for translation initiation at non-AUG start codons Translation rate is controlled by coupled trade-offs between site accessibility selective RNA unfolding and sliding at upstream standby sites and optimization of multi-protein genetic systems in diverse bacteria Prokaryotic gene clusters: a rich toolbox for synthetic biology Combinatorial pathway engineering for optimized production of the anti-malarial FR900098 Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis The CMA evolution strategy: a comparing review CrossRef Full Text | Google Scholar “DIRECT global optimization algorithm,” in Encyclopedia of Optimization Pardalos (Dordrecht: Kluwer Academic Publishers) Google Scholar Google Scholar A synthetic biology framework for programming eukaryotic transcription functions Composability of regulatory sequences controlling transcription and translation in Escherichia coli Systems metabolic engineering of microorganisms for natural and non-natural chemicals Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay CRISPR EnAbled trackable genome engineering for isopropanol production in Escherichia coli Precise and reliable gene expression via standard transcription and translation initiation elements Rational design of a synthetic Entner–Doudoroff pathway for improved and controllable NADPH regeneration Advances in genetic circuit design: novel biochemistries Protein evolution on partially correlated landscapes Chapter 8: A Comprehensive Survey on Fitness Landscape Analysis Studies in Computational Intelligence 2014 Google Scholar R Core Team (2017). R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Satistical Computing. Available at: https://www.r-project.org/ Google Scholar The development and characterization of synthetic minimal yeast promoters Derivative-free optimization: a review of algorithms and comparison of software implementations CrossRef Full Text | Google Scholar Exploring protein fitness landscapes by directed evolution Automated design of synthetic ribosome binding sites to control protein expression construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes Functional optimization of gene clusters by combinatorial design and assembly Synthetic biology to access and expand nature’s chemical diversity Programming cells by multiplex genome engineering and accelerated evolution Correlated and uncorrelated fitness landscapes and how to tell the difference CrossRef Full Text | Google Scholar Local properties of Kauffman’s N-k model: a tunably rugged energy landscape CrossRef Full Text | Google Scholar Modular optimization of multi-gene pathways for fatty acids production in E Improving metabolic pathway efficiency by statistical model-based multivariate regulatory metabolic engineering Customized optimization of metabolic pathways by combinatorial transcriptional engineering Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA Das SR and Smanski MJ (2018) Simulation Modeling to Compare High-Throughput Low-Iteration Optimization Strategies for Metabolic Engineering Copyright © 2018 Heinsch, Das and Smanski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Michael J. Smanski, c21hbnNraUB1bW4uZWR1 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish IXONIA  – When tractor enthusiasts gather on May 28-30 at the Ashippun Firemen’s Park for the 11th annual Ixonia Vintage Tractor Expo for the first vintage tractor show of the season This year the club is featuring Massey Harris is particularly happy about the featured tractors this year because his collection includes two Fords The 90-year-old tractor enthusiast has never missed a meeting of the Ixonia Vintage Tractor Club since members began gathering more than a decade ago. The club was formed with the idea of hosting an antique tractor show early in the season when tractor enthusiasts are getting anxious to get out to show off their collections Rupnow’s interest in tractors dates back to his early years on the farm that was started by his grandfather in 1856. He remembers farming with horses and then steel wheeled tractors He proudly bought his first tractor in 1948 at the age of 18 - a Ferguson T20 The nonagenarian purchased Ferguson tractor for practical purposes and then added a second Ferguson years later at a local auction The machine appeared a bit rusty but Rupnow says it was only surface rust and the rest of the body was in really good shape.  The Ixonia residents says he get a helping hand restoring the old tractors from his son-in-law Tom Heinsch who is equally enthusiastic about the old machines. With professional experience in the auto body business Heinsch is able to do a good job painting and restoring the old tractors in Rupnow’s collection Heinsch also accompanies Rupnow top tractor shows. A few years ago Heinsch and his father-in-law were driving their tractors home from a show when the wheel weight on the back tire of his tractor came off The dangling weight dug into the blacktop and as a result the back axel of the tractor broke. The tractor flipped end over end and Heinsch was severely injured The accident hospitalized for a couple of months but he is now recovered from his injuries and is back to driving tractors to shows again Heinsch says he feels extremely lucky to be alive. He remembers severe rubber burns on one side of his body and a large gap in the other side that bled profusely. When doctors cleaned his wound they found the blue paint from the spring-loaded wheel weights in the wound The two still drive the tractor but they have welded the wheel weights on tight so they cannot come off while driving the tractors Heinsch believes he was travelling about 13 miles per hour at the time the accident happened travel much faster than that due to the original motors being replaced with six- or eight-cylinder truck motors Rupnow says Funk Conversion made a kit to put a flat head 6-cylinder motor into the Ford tractor replacing the 4 cylinder motor. The company got into the conversion business making parts for the military during World War II One of the family's Ford tractors has a custom buddy seat for passengers. The seat was designed and built by Heinsch with used farm equipment parts and two folding boat seats “Before anyone can ride in these seats in a tractor parade we need to put a bumper on the back for safety,” Heinsch says Both Heinsch and Rupnow have driven their tractors several times across the Mackinac Bridge taking part in the annual tractor parade at St Ignace each September. The 2020 event was cancelled but they hope to make the drive again this year Rupnow also has an Oliver tractor that is still in the midst of restoration and will not be included in the family's lineup of entries in the upcoming show Big changesThe former dairy farmers says he milked cows on his farm until he was about 70. He sold his dairy herd in the late 1990s due to requirements from the Department of Natural Resources regarding manure handling and storage Up until that time he had milking about 100 cows on a farm that is located along the Rock River Rupnow says it wasn't feasible to make such a financial investment for the mandated changes so he opted to continue cropping the farm’s 275 acres and raising some steers and heifers Although Rupnow uses a walking stick, don’t let that fool you The spry tractor enthusiast still drives tractor and manages the land In February their barn burned down and they lost 23 calves in the fire Luckily some other livestock was saved Rupnow commends the local volunteer fire department and the many area volunteer fire departments that assisted in saving a portion of the barn and protecting his house that was located adjacent to the barn a collector Oliver tractor in the midst of restoration was parked near the barn The extreme heat burned the paint off of the tractor “I used to do custom digging – ditches tile lines. I got it in 1950 and still use it for repairing tiles in the fields,” he said adding that the machine runs off the power take-off of a tractor Upcoming showRupnow is looking forward to the Ixonia Vintage Tractor Expo’s show in Ashippun on Memorial Day weekend He's easy to spot among the crowd as he will be sporting his signature bright yellow fuzzy Green Bay Packer hat “I’ve been wearing that hat to all the tractor shows for many years and people know me by my hat,” he says with a grin Founder Henry George "Harry" Ferguson was an Irish-born British engineer and inventor known for his development of the modern agricultural tractor he founded a company which included tractor retail “The Ferguson System” was developed over a 30-year period and is an automatic control system now employed by almost all tractor manufacturers worldwide the first Ferguson tractors were built by the David Brown Company Ferguson worked for a time with Henry Ford in order to make production of his tractor more efficient Ferguson merged with Massey Harris and each kept their brand name until 1958 when the company became known as Massey Ferguson One of Fergusons most successful designs was the Ferguson TE20 a light-weight machine still popular with enthusiasts like Bill Rupnow today The diminutive machine marked a major advance in tractor design There are sure to be plenty of “Fergies” and Masseys at the Memorial Day weekend show in Ashippun as well as a variety of Ford tractors. The entire weekend show is free of charge The weekend activities will begin with a tractor drive on Friday May 28. The main show is on Saturday and Sunday< May 29-30 and will include and a kids Pedal Pull. Pedal tractors will also be available for kids to ride To learn more about the show or to be a vendor contact Curt Pernat at 920-988-0857.  To learn details of the car show planned for Sunday contact Luke Pernat at 262-719-6669 43 minutes and featured a little bit of everything several hit batters and more than enough squandered scoring chances Carson Heinsch beat out a routine groundball to second base with two outs in the bottom of the 12th inning to rally the Black to a wild 8-7 victory over Portland Oregon in a National Division game Tuesday night at Diethrick Park The win evened Moorhead’s record at 2-2 which led 7-6 after scoring the go-ahead run on a bases-loaded walk in the top of the 12th will have little time to dwell on the gut-punch loss because it is scheduled to face Norwalk But can the Pacific Northwest Regional champions rebound Moorhead enters its off day feeling pretty good After scoring three runs in the seventh to tie the game 6-6 and send it into extra innings — J.J Dunlap’s RBI single and Taye Reich’s two-run double were the big blows — the Black lost the lead in the top of the 12th thanks to three walks and a hit batter Logan Olson drew a one-out walk from Portland losing pitcher Brave Johnson Conner Zimmerman and Dunlap both bunted for base hits and Olson later scored on a wild pitch to tie the game 7-7 And when Heinsch bounced a grounder to the Portland second baseman it looked like a 13th inning was in the offing Except Heinsch beat the throw to first and Zimmerman raced home with the winning run worked six innings in relief and didn’t allow a run in the last five in a game that was played in intermittent rain Zimmerman issued a walk that allowed the go-ahead run to score in the 12th Portland plated two runs without the benefit of a hit in the fourth off starter Heinsch Moorhead tied it 3-3 it with two runs in the fifth but found itself trailing 6-3 heading into the bottom of the seventh That’s when the craziness was ratcheted up even more what appeared routine was anything but and the boys from Minnesota walked it off Roscoe Mithoefer (double) collected three hits to earn Tellefsen Most Outstanding Player honors for Portland and teammate James Gill reached base all six times he batted highlighted by a first-inning double off the right-field wall — Zach Shipman collected three hits and drove in a pair of runs to lead Eau Claire Wisconsin to a 10-5 victory over Broomall Newtown Pennsylvania in Game 14 of the Babe Ruth 13-15 World Series on Tuesday at Diethrick Park Contributing two hits apiece for the winners (3-1) were Blake Bugher The Ohio Valley Regional champions led from start to finish ultimately putting the game away with a four-run fifth inning Bugher’s two-run single and Pankratz’s RBI double highlighted the rally innings before being relieved by Gavin Thompson Jack Quinn took the loss for Broomall Newtown (0-3) Donny Reick belted a two-run double in the third inning on his way to be named the Tellefsen Most Outstanding Player The northern pike is known for being a species that bites year-round Whether fishing through the ice or taking in .. ERIE — Four members of Warren’s boys tennis team traveled to the Westwood Racquet Club on Saturday to .. High School track and field invitationals went deep into the night Friday Thirteen Warren Dragons and one Eisenhower Knight help make up rosters for the 2025 New York vs Copyright © 2025 Ogden Newspapers of Pennsylvania LLC | https://www.timesobserver.com | PO Box 188 Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInSIOUX FALLS (Dakota News Now) - The Augustana baseball team earned a dominant win before marching back from an eight run deficit to earn a walk-off win and complete a four-game sweep over Winona State at Ronken Field on Sunday afternoon The first game of the day completed a three-game NSIC series and game two was a non-conference affair The Vikings move to 24-11 overall and 18-7 in the NSIC while Winona State falls to 16-19 Carter Heinsch continued his recent tear with four hits while Troy Berg had four hits Trevor Winterstein and Sam Siegel had three hits apiece while Ryan Clementi (3 RBI) and Joshua Koskie had two each allowing an unearned run and three hits while striking out eight in 6 2/3 innings Joel Van De Stroet struck out a pair in the eighth inning to wrap up the day scoring two runs in the first three batters for the early lead Jason Axelberg led the second inning with a bunt single and got to third on a Troy Berg double to left Clementi got the job done on the next pitch scoring both on a single to even the scoring Siegel reached on a one out single and Berg had a two out bunt hit to get Siegel into scoring position driving a single through the left side to bring in Siegel and give AU a 3-2 lead Berg would end up stealing third to get runners on the corners paying off when Koskie singled to left to score Berg and grow the lead Winterstein kept it rolling after fighting off six straight full count pitches with an infield single scoring Clementi before a throwing error on the play scored Koskie Heinsch gave the fresh arm a warm reception with a double to right center scoring Winterstein and Hines followed with an RBI single of his own to round out the third inning strike and give AU an 8-2 lead The offense stalled on both sides until the sixth inning Ragan Pinnow and Siegel each walked to open the sixth both came home on a two-run double off the bat of Berg to make it 10-2 AU WSU scraped across an unearned run to get within seven The Vikings struck again in the bottom of the eighth to finish off the run-rule shortened game Pinnow led off with a single and got to third on a Siegel single A passed ball allowed Pinnow to score and Berg sent a blast to left to seal the deal Berg closed the day with a walk-off single to close a wild non-conference matchup Heinsch and Kobe Eikmeier had three hits apiece while Berg Jadon Bast and Ryan Clementi completed the first five innings on the mound Drew Ball shoved through the final four frames with four strikeouts and didn’t allow a hit to earn his first win of the season Winterstein opened his 10th consecutive game on base with a single and Heinsch walked before a double steal moved them into scoring position A dropped pop fly scored Winterstein and Siegel delivered an RBI knock to give AU a 2-0 lead The Warriors marched back with two runs in the second inning Bryson Bohannon drew a one-out walk and Kobe Eikmeier sent a two-run blast to left the Warriors tallied 10 runs on nine hits to take a commanding 12-4 lead the Vikings began to chip at their deficit Heinsch walked and Berg was hit by a pitch to bring in two runs Pinnow drove a single up the middle to score a pair and Siegel brought in another run on a fielder’s choice to bring AU within 12-9 starting with a Koskie leadoff single and a one-out single from Eikmeier put runners on the corners Winterstein got a job done with a groundout that scored a run and Heinsch delivered a two-run blast to the opposite field to even the game at 12-12 Ball continued his excellent outing with a 1-2-3 eighth inning and a strikeout to close the ninth and keep the game tied Winterstein and Heinsch each singled to get runners on the corners and Berg singled to walk-off the Warriors and complete the four-game sweep The Vikings continue their home stretch Tuesday afternoon with a doubleheader against Wayne State Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here This website is unavailable in your location It appears you are attempting to access this website from a country outside of the United States therefore access cannot be granted at this time COLD SPRING – The Bemidji High School baseball team saw its season end on Thursday afternoon in Cold Spring 3 Moorhead in walk-off fashion in the Section 8-4A Tournament elimination bracket championship game The Jacks plated five runs in the first two innings on Landon Hanson’s bases-loaded walk and RBI singles from Peyton Neadeau and Stonewall Gessner Moorhead tied the game with two runs in the third and three in the fifth Hanson scored on an error in the top of the seventh inning to give Bemidji a 6-5 lead an RBI single and a throwing error sealed the Lumberjacks’ fate in the bottom half of the frame walked two more and surrendered three hits Carter Heinsch came in for relief in the first inning and went the distance from there for the Spuds He allowed two earned runs on eight hits wth three strikeouts The Jacks ended their season with a record of 13-11 “While there have been extraordinary research advances in healthcare translating these advances into tangible social benefits has remained a significant challenge,” says Dr Heinsch “Multiple models for the translation of evidence into policy and practice have been articulated most are linear and very few come close to reflecting the dense and intricate relationships politics and processes required to enact sustainable improvements The inherent complexity of knowledge translation highlights the need for multidimensional iterative and flexible approaches that transcend disciplinary boundaries.” “My research draws on creative and critical perspectives from a range of fields economics and organisation science to understand how knowledge is created embodied and collectively negotiated,” Dr Heinsch explains “In keeping with Milena’s commitment to developing interdisciplinary scholarship the ITEM brings together the latest theoretical and empirical evidence for effective translation and engagement from the social into a sophisticated and coherent framework to guide the implementation of eCliPSE into four local health districts,” says Professor Kay-Lambkin Fontbonne freshman pitcher Arianna Heinsch (#21) gets a congratulatory helmet slam from Emily Manti (right) as she crosses the plate after hitting a home run in the sixth inning to narrow the gap by one run in a 7-6 loss to Mary Louis on opening day With his two senior pitchers moving on to college Fontbonne Varsity Softball Head Coach Frank Marinello is placing his faith in two freshmen hurlers to keep the Bonnies competitive for the 2017 season Lining up first in the pitching rotation is Arianna Heinsch Arianna has proven to be a steady performer on the mound with a number of years of travel team experience with the New York Cyclones Second in the rotation is newcomer Anna Acevedo who also has travel team experience most notably with the Dyker Heights Knights According to Fontbonne Pitching Coach Robert Rocca “Anna has a lot of potential and is a work in progress.” Rocca is looking forward to improving the freshman’s pitching mechanics so she can be successful against tougher competition For the Bonnies who ended the 2016 season with a stinging 3-2 late inning loss to St that game has still carried over during the off-season according to Emily Manti who is a member of this year’s seven Varsity seniors “We still should be pretty good this year,” maintained senior Samantha Marletta whose four-year Varsity sister Bianca is now pitching for Mount St “We’ve got a good defense; all we have to do is put the ball into play with some good line drives.” Insisting that his team would still remain competitive at the end of the 2016 season Coach Marinello stated that it was time for his underclassmen to step up along with forthcoming additions to the Varsity With the completion of this weekend’s pre-season practice it appears that those pieces are now in place After the Bonnies posted a 4-0 lead in the second inning that featured a booming triple by Alexa Bertelle Mary Louis rallied back in the third inning to take a 7-4 lead the Bonnies made an attempt to come back with a solo home run by Heinsch to make the score 7-6 but fell short on a golden opportunity to win the game on an inning-ending strikeout with the bases loaded The element requested is either not valid or does not exist FARGO — F-M Upward Sports not only helps students physically through athletics but also spiritually Christian-led youth sports organization that combines the gospel with recreational activities The local chapter caters to more than 1,000 students from grades K-8 in the Fargo-Moorhead area Teams practice and play at one of the three Upward Sports churches Calvary United Methodist and Northview Church all provide their facilities Students interested can choose from four different sports offered throughout the year including basketball FM Upward Sports director Glenn Heinsch said providing activities throughout the year is crucial to help connect with families "We really want to make it a year-round ministry," Heinsch said "So that we are always interacting with these families." Heinsch was previously the Upward Sports director in Celebration but moved to the F-M area in the fall of 2017 to be closer to his wife's parents and his children's grandparents He then took up the role of F-M Upward Sports director Heinsch spends time with the players and spreads God's message during breaks in practices and games we'll share a devotion for three or four minutes while they have their water break," Heinsch said we do some type of fun activity that's focused and centered on some Biblical truth." By using the organization to bring students together and spreading the Christian faith Upward Sports is allowed to use the three churches' facilities at no cost Having games at the church is not only beneficial to Upward Sports "It is just a great outreach for these churches," Heinsch said "There are not many other things that will bring in 300 kids and their families every Saturday They can come and see what the church looks like what activities they have and what ministries they have I encourage the churches and the pastors to have materials out for things they offer so the churches really see the potential they have in these families that are there to play basketball." Pastors of the host churches have noticed a rise in their congregation size as a result of Upward Sports Participation in the sports Upward offers has risen consistently the basketball program is seeing about 850 students Park Christian School in Moorhead will also offer their facilities for Upward Sports The addition will allow for more students to participate in the various sports and increase the program's capacity to 1,100 students Even during the high-points of the pandemic Upward Sports' attendance number never dropped "We did not see a decline in any of our numbers in any of our sports," Heinsch said The organization left the decision to continue competition up to the churches and families Of the parents that let their kids participate they were pleased to get their kids out of the house and kept repeating "Thank you for giving our kids something normal to do." Upward costs around $100 a season to participate but players receive a full uniform that serves as both game and practice attire provides most of the equipment necessary for each sport providing guidance to students through faith and athletics is a rewarding experience "That's why I do what I do and that's why churches allow us to come in," he said "To have that impact on them that goes far beyond basketball or football." Frances Kay-Lambkin receives funding from the National Health and Medical Research Council (Australia) She is affiliated with the Society for Mental Health Research (current President) Dara Sampson and Milena Heinsch do not work for own shares in or receive funding from any company or organisation that would benefit from this article and have disclosed no relevant affiliations beyond their academic appointment University of Newcastle provides funding as a member of The Conversation AU View all partners We’ve now been social distancing for several weeks While these measures have allowed us to slow the spread of COVID-19 If you’ve found yourself experiencing feelings of fear people with pre-existing mental health conditions and people experiencing financial pressure could be particularly vulnerable to psychological distress at this time When feelings of psychological distress increase suicidal thoughts and behaviours may also increase So how do we know when to be worried about someone we love we may all be feeling more stressed than usual That’s why we need to stay connected with each other online But it’s important we’re attuned to whether this extra stress and uncertainty is developing into something more for any of the people we care about Some warning signs for suicide might be easier to recognise when you can see a person’s facial expressions and gestures But there are cues you can pick up on during text Social withdrawal can indicate a person is at greater risk Perhaps a friend or relative is increasingly difficult to contact via phone or text disappears from social media or starts saying they just want to be alone A persistent drop in mood might be revealed on the phone by a flat tone of voice and by shorter text messages or none at all Some people might say things like “you’d be better off without me” or “there’s nothing to live for”, which suggest they can’t see a way out of their situation and may be thinking about suicide If you’re worried someone you know might be suicidal, reaching out and having a conversation could save their life Choose a time and place where you can talk openly and without getting interrupted This might be challenging when whole families are at home together for extended periods But these can be sensitive and confronting conversations and it’s important to protect the person as well as people in your family or household You could start the conversation by asking your friend or loved one how they are You might also let them know you’ve noticed a change in them: “you don’t seem yourself” Starting the conversation may look different if you’re online Perhaps someone has posted a comment or image on social media that seems unusual for them or which makes it seem like they’re thinking about suicide contact them directly by sending a private message Once you’ve started the conversation, ask directly about suicidal thoughts and intentions (for example Then you just have to listen with supportive statements Say things like “that sounds really tough” rather than “don’t be silly” You might feel worried about having a difficult conversation on the phone or online but this style of communication actually has some benefits People may feel more comfortable revealing suicidal thoughts, without fear of stigma And sometimes people find it easier to communicate via emoji GIFs or images rather than having to find the words to express how they’re feeling listening on the phone or via messaging gives us time to think about how to best respond This is important because negative reactions like criticising or dismissing someone’s feelings may make the person less likely to seek help and increase their thoughts of suicide If you’re worried about someone and you think they’re at risk of suicide, offering help is important. Our research with people who had previously attempted suicide found although participants wouldn’t necessarily seek help many said they would accept it if it were offered While talking with the person you’re worried about is an important first step, you may be able to guide them towards professional help. For example, they may want help to make an appointment with a GP or counsellor, or to call a crisis line or if you’re concerned about someone you know a research assistant at the University of Newcastle With the support of third baseman Abby Fogliano (foreground) and Emily Manti at first base freshman pitcher Anna Acevedo recorded her first league win in a 17-1 “Mercy Rule” game over St The Fontbonne Varsity Softball Team went from one extreme to the other last week when it lost a tight one-run game to the Molloy Stanners Saviour Pandas with a multitude of runs for the Bonnies current league record of 3-3 Even if it was a tough loss for the visiting Bonnies the Fontbonne coaching staff still agreed that their 1-0 loss to the Stanners was still one of the better games played thus far this season The game turned out to be a match-up of standout freshman hurlers as Fontbonne’s Arianna Heinsch sent down eight Stanners on strikeouts while only giving up only one hit Heinsch’s Molloy counterpart Kelsy Carr was even more stellar on the mound with 16 strikeouts while giving up only two hits By mid-game it was evident that the team that would blink first was going to lose  That “blink” came in the fourth inning for the Bonnies when Abby Fogliano cleanly fielded a grounder at third base but subsequently hit the Stanners’ Carr running down to first base with a sharply angled throw That errant throw would score Molloy’s Jessica Hickey the only Stanner to record a hit (a double) off of Fontbonne’s Heinsch made her league debut in Fontbonne’s second meeting with St Acevedo surrendered only one run to the Pandas while striking out five The Bonnies scored often and early as Fogliano’s sacrifice fly scored Alexa Bertelle for the first run of the game Emily Manti topped off the first inning with a bases-clearing shot into left center field for a grand slam to put Fontbonne up 5-0 at the end of the first inning the Bonnies were still pounding the ball as Sydney LaCognata sent a double to left field to score two runs that would ring up the score to 8-0 by the end of the second inning The “Mercy Rule” was put into effect again for the second time this season for the Bonnies’ eventual 17-1 win 2011 at 7:55 pm ETSix property sales were recorded last week by the Town Clerk: Liu sold to Deidre Absolonne and Pierrick Absolonne for $1,095,000 26 Raymond St.: Rebecca Aikman sold to Ian S Information obtained from the  and with the assistance of Ken Allen of Coldwell Banker Get more local news delivered straight to your inbox. Sign up for free Patch newsletters and alerts. The KNAW has rewarded 11 Leiden scientists for their commitment to science communication by awarding them 10,000 euros each from the ‘Appreciated!’ fund Although interaction between science and society is of enormous importance, science communication is still far from being recognised as integral to science. The pilot fund ‘Science Communication by Scientists: Appreciated!’ – set up by the Dutch Ministry of Education Culture and Science and administered by the Academy – takes a step towards showcasing and rewarding the many scientists who have dedicated themselves to science communication Nieuwscheckers: Factchecking as a weapon against disinformation and misinformation in health and politics (in Dutch) Religious studies in secondary education (in Dutch) Database of Business Ethics: facilitating research into among others, whether multinationals comply with their codes of conduct Advancing knowledge about international humanitarian law. New generation, new archaeology: bringing young people in contact with 21st century archaeology (in Dutch) The Hague Diplomacy Platform: the role of diplomacy in international politics Old Observatory/Oude Sterrewacht: sparking public interest in different aspects of astronomy Music in neuropsychology Innovation in citizen science: iSPEX and Citizen Science Lab #Braintalk: what do you want to know about your brain? ‘Genetic testing’: the advantages and limitations of DNA testing (in Dutch) The KNAW has awarded funding to 91 applications submitted by 62 faculties from all the Dutch universities. More information from KNAW. Imagine a free program in which mental health issues could be rapidly attended to at any time of the day or night Imagine if it wasn’t just a one-size-fits-all solution but could be tailored to the needs of that individual And imagine if such a program was proven to have wide-ranging Thanks to a dedicated team of clinical researchers this is not a pipe dream and is being refined and scaled up to help even more people it provides 24/7 access to self-help tools and a geo-location service that links people with services in their local community According to Chief Investigator Milena Heinsch who is based at the University of Newcastle digital program to assist people with mental health issues has been critical during the COVID-19 pandemic mental health problems in Australia were common with more than 10 million Australians experiencing a mental disorder at any one time,” she says we have seen an overall rise in symptoms of anxiety and coping responses to stress including increased drug and alcohol use amongst the general population Reporting rates of depression and anxiety symptoms are twice as high as in 2017 this has resulted in an increase in alcohol and other drug use to manage their mental health.” Given the high association between mental health and alcohol and other drug use the ongoing stress related to the COVID pandemic is likely to exacerbate people’s mental wellbeing researchers have been developing a variety of digital interventions to treat mental health and substance use led by Professor Kay-Lambkin [who is also working on eCliPSE] provided young people with instant access to online intervention packages which taught them to use cognitive behaviour therapy and motivation enhancement techniques to self-manage thoughts feelings and behaviours related to depression and alcohol consumption,” Heinsch says “This trial provided the first evidence of the impact of digital tools for both alcohol use disorders and depression Participants reported that they had reduced both their frequency of binge drinking by 18% and their depressive symptoms by 35%.” eCliPSE was developed as a new, integrated platform, with all the necessary tools and resources available at the one site (www.eclipse.org.au) people are recommended the treatment programs on the site that are most suited to help them At any time they can download their results to discuss them with their GP or other healthcare providers “The evidence shows us that there will always be a role for a clinician to be checking in with people about their progress,” Heinsch says such as one suitable for those using methamphetamines or another for binge drinkers have each been shown to be effective in stand-alone trials the eCliPSE website has been redeveloped to increase its uptake across NSW This has resulted in a 26% growth in new visitors to the site and an average increase of 24% in time spent on the eCLiPSE platform Heinsch says the next step is to test different ways of encouraging more NSW residents to access the site “Access to high quality evidence-based treatment is an imperative,” she says “Digital treatments offer an important solution With key dates and news about health and medical research in NSW We pay respect to the Traditional Custodians and First Peoples of NSW and acknowledge their continued connection to their country and culture