You can read this article in 2 minutesAgnieszka Kulikowska - Wielgus In view of the large increase in the number of immigrants trying to enter the UK illegally by truck, the governor of the Belgian province of Liège has imposed a night-time ban on one of the parking lots the Belgian province of Liège issued a decree prohibiting parking at the Aire de Tignée parking lot in Barchon near Soumagne at E40/E42 (routes leading to Calais and Dunkirk) The ban applies to vehicles over 3.5 tonnes and is in force between 8 p.m The reason for this measure is the growing number of immigrants trying to get to the British Isles by truck The ban was introduced at the request of the mayors of Blegny and Soumagne – Marc Bolland and Benjamin Houete The authorities and the inhabitants of both towns are concerned about the presence of refugees trying to break into trucks.  Barchon : le gouverneur confirme la fermeture du parking autoroutier aux camions vers Bruxelles Le gouverneur de la province de Liège le confirme dans un communiqué : l’aire de stationnement de Barchon – située plus exactement à Tignée sur la commune d… https://t.co/SJZ5ZzUTE0 pic.twitter.com/AKYgDI9qoG — Veille infopol (@PolBegov) October 22, 2019 The ban was introduced on 23 October for 2 weeks the Governor shall decide to extend or remove the restriction Pölös Zsófia Journalist Trans.info | 5.05.2025 Agnieszka Kulikowska - Wielgus Journalist Trans.info | 5.05.2025 Sabina Koll Journalist Trans.info | 5.05.2025 GXO to manage Northern Italy transport operations for PRG retail groupPölös Zsófia Journalist Trans.info | 5.05.2025 The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission Medical Mycology Case ReportsCitation Excerpt :Further the examination of the patient's bagpipe revealed a contamination with several fungi as mentioned above Contamination of wind instruments with fungi [9] and cases of HP triggered by fungi were described before [10,11] but still rarely reported With this article four potential fungal trigger of HP in a bagpipe player are described: Exophiala phaeomuriformis Kwoniella europaea and Aureobasidium melanogenum Respiratory MedicineCitation Excerpt :Among the many factors and circumstances that contribute to the development of domestic HP are contaminated humidifiers faulty ventilation systems and jacuzzis (Mycobacterium avium) [30,31] Even HP due to leisure activities [32–34] are now recognized [14] A query on http://www.ncbi.nlm.nih.gov/ with the following keywords: hypersensitivity pneumonitis (HP) farmer's lung and other specific disease names derived from occupational activities followed by each etiology with their synonyms evaluated the number of publications related to the different etiologies of HP All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. Objectives: Different phenotypes have been identified in acute respiratory distress syndrome (ARDS). Existence of several phenotypes in coronavirus disease (COVID-19) related acute respiratory distress syndrome is unknown. We sought to identify different phenotypes of patients with moderate to severe ARDS related to COVID-19. Methods: We conducted an observational study of 416 COVID-19 patients with moderate to severe ARDS at 21 intensive care units in Belgium and France. The primary outcome was day-28 ventilatory free days. Secondary outcomes were mortality on day 28, acute kidney injury, acute cardiac injury, pulmonary embolism, and deep venous thrombosis. Multiple factor analysis and hierarchical classification on principal components were performed to distinguish different clinical phenotypes. Conclusions: In COVID-19 patients with moderate to severe ARDS, we identified three clinical phenotypes. One of these included older people with comorbidities who had a fulminant course of disease with poor prognosis. Requirement of different treatments and ventilatory strategies for each phenotype needs further investigation. Intensive Care Medicine and Anesthesiology Volume 8 - 2021 | https://doi.org/10.3389/fmed.2021.632933 Objectives: Different phenotypes have been identified in acute respiratory distress syndrome (ARDS) Existence of several phenotypes in coronavirus disease (COVID-19) related acute respiratory distress syndrome is unknown We sought to identify different phenotypes of patients with moderate to severe ARDS related to COVID-19 Methods: We conducted an observational study of 416 COVID-19 patients with moderate to severe ARDS at 21 intensive care units in Belgium and France The primary outcome was day-28 ventilatory free days Secondary outcomes were mortality on day 28 Multiple factor analysis and hierarchical classification on principal components were performed to distinguish different clinical phenotypes Results: We identified three different phenotypes in 150 Phenotype 3 was characterized by short evolution Phenotype 1 was mainly characterized by the absence of comorbidities whereas phenotype 2 was characterized female sex and the presence of mild comorbidities such as uncomplicated diabetes or chronic hypertension The compliance in phenotype 2 was lower than that in phenotype 1 Phenotype 3 was associated with higher mortality compared to phenotypes 1 and 2 Conclusions: In COVID-19 patients with moderate to severe ARDS One of these included older people with comorbidities who had a fulminant course of disease with poor prognosis Requirement of different treatments and ventilatory strategies for each phenotype needs further investigation Coronavirus Disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have different clinical presentations, but respiratory symptoms predominate, and may induce acute respiratory distress syndrome (ARDS) (1) Indeed, most of the validated sub-phenotypes were based on biomarker dosages, which were time-consuming and somewhat costly. These caveats preclude sub-phenotyping of ARDS patients in routine critical care, while immediate interventions are often required. Conversely, phenotyping using simple clinical data could be immediately useful at bedside (9) To investigate whether different clinical phenotypes of COVID-19 ARDS really coexist and lead to different outcomes, we performed a post-hoc analysis of patients included in the COVADIS study [i.e., patients with moderate or severe COVID-19 related ARDS admitted to 21 ICUs in Belgium and France (11–14)] Patients were phenotyped according to two main determinants: demographic characteristics and respiratory characteristics upon initiation of mechanical ventilation Classification was conducted without considering clinical outcomes and we compared the outcomes of the different sub-phenotypes This multicentric prospective observational study included 21 ICUs in France (n = 12) and Belgium (n = 9) The COVID-19 pandemic began in France in the 2nd week of March 2020 and 1 week later in Belgium - Moderate to severe ARDS according to the Berlin definition (15) (PaO2/FiO2 ratio <200 mmHg with a PEEP of at least 5 mmHg receiving invasive ventilation) - Positive SARS-CoV-2 reverse transcriptase polymerase chain reaction (PCR) - Extra corporeal membrane oxygenation (ECMO) requirement within the first 24 h of ICU admission - Chronic obstructive pulmonary disease with Global Initiative for Chronic Obstructive Lung Disease (GOLD) class 3 or 4 (16) For this observational prospective multicenter study, all consecutive COVID-19 patients were screened in the participating centers. Patients fulfilling the inclusion and exclusion criteria were included in participating ICUs between March 10, 2020 and April 15, 2020. Each local investigator filled an eCRF to collect data (Castor EDC, Amsterdam, The Netherlands). We recorded demographic data, medical history, and comorbidities using the Charlson score (17) along with the history of chronic hypertension We collected the PaO2/FiO2 ratio and the settings of the mechanical ventilator (MV) after intubation [tidal volume (Vt) administration of advanced therapies for acute respiratory failure (neuromuscular blocking agents immunomodulatory agents (interleukin-6-receptor antagonists and corticosteroids) time from onset of symptoms and occurrence of acute kidney injury (AKI) acute cardiac injury (defined as a rise in troponin level over 10 times the normal threshold) The pre-specified primary endpoint was the number of ventilator-free days (VFD) at day 28 (18) - VFDs = 0 if subject died within 28 days of mechanical ventilation - VFDs = 28 – x if the subject was successfully released from ventilation x days after initiation - VFD = 0 if the subject was mechanically ventilated for >28 days The variable was dichotomized into “patients still ventilated or dead on day 28” (VFD = 0) vs “patients weaned and alive on day 28” (VFD > 0) - Ventilator mode on day 14 according to four pre-defined categories: patient under volume/pressure assisted controlled or ECMO - Acute cardiac injury was defined as a plasma troponin level > 10 times the upper normal range - AKI which was defined as a rise in serum creatinine of at least 50% as defined in Kidney Disease Improving Global Outcomes (KDIGO) stage 1 (19) - Need for renal replacement therapy (RRT) This study was approved by the appropriate regulatory committees in France (Commission National Informatique et Libertés n°2217488) and Belgium (Comité Ethique ERASME Université Libre de Bruxelles n°P2020/253) as per national regulations The requirement for written informed consent was waived Continuous variables were described as median (25–75th percentiles) and categorical variables as number (percentage) We performed a multiple factor analysis (MFA) with these variables followed by hierarchical clustering on principle components (HCPC) (20) the quantitative variables were categorized according to commonly used cutoffs [body mass index (BMI) duration between onset of symptoms and antiviral treatment The variables were divided into two groups: demographic data (age and medical history) and respiratory data (PaO2/FiO2 ratio at baseline and duration between onset of symptoms and antiviral treatment) This was for balancing characteristics between past medical history and characteristics (especially respiratory characteristics) of the disease we gathered them based on common pathophysiology: chronic hypertension / diabetes mellitus without complication / chronic respiratory failure / history of gastroduodenal ulcer / history of cancer / connectivitis or HIV / mild to moderate hepatic failure / dementia hemiplegia or history of stroke / moderate chronic kidney diabetes mellitus with complication / congestive heart failure and static compliance of the respiratory system calculated as Crs = (Plateau pressure – PEEP)/ Vt and presence of a co-infection at baseline MFA, which belongs to a family of descriptive methods, is an extension of correspondence analysis that assesses contingency tables exploring simultaneous relationships among variables structured in groups to describe correlations between variables and patients. It appears to be a counterpart of principal component analysis for categorical data, used to detect and represent underlying structures in a dataset as points in a low-dimensional space (21) we defined the number (N) of clusters as the number after which the increase of between-cluster inertia from N-1 to N clusters was more important than the inertia's increase from N to N+1 clusters we calculated the ratio between the value of the increase in between-cluster inertia from N-1 to N clusters divided by the increase in between-cluster interest from N to N+1 clusters (N ranging from the number of patients to 1) We selected the number of clusters as N with minimal ratio a plot was produced by projecting the patients and center of gravity of each cluster Classification was conducted without consideration of clinical outcomes The clusters thus identified were described by comparing the frequencies of different variables using the Chi-square test or Fisher's test and analysis of variance (ANOVA) or the Kruskal–Wallis test if the normality tested by a Shapiro Wilks test has not been concluded for quantitative variables Two close phenotypes were compared using correction of the alpha risk by the Holm method P < 0.05 was considered statistically significant and factor map of candidates' characteristics (panel B) Patients characteristics according to phenotype A total of 407 patients were available on day 28 for follow-up. As shown in Table 2, patients classified into phenotype 3 had lower number of VFDs on day 28. The probability of death was high in this phenotype, whereas the probability of breathing without assistance was low (Figure 2). Conversely, phenotypes 1 and 2 had similar numbers of VFDs and survival rates (Table 2 and Figure 2) Probability of dying or being weaned over time during 28 days In this observational study of moderate to severe ARDS complicating COVID-19 in France and Belgium we attempted to identify different clinical phenotypes of this new disease using simple bedside available clinical data we identified three main clinical sub-phenotypes that had different clinical characteristics Phenotyping may be useful in this setting for identifying a subset of patients with a high likelihood of a given outcome and to better describe a previously unknown disease in an unbiased manner we were not able to validate our findings in an external cohort especially including patients from both waves but prepare a dedicated file to help clinicians who share with us interest in this project In COVID-19 patients with moderate to severe ARDS we identified three clinical phenotypes based on patient and disease characteristics One of these included old people with comorbidities who had a fulminant course of disease with poor prognosis Despite differences in the compliance of the respiratory system on other days Our study allows the early identification of clinical phenotypes The requirement of different treatment and ventilatory strategies for each phenotype needs further investigation The data analyzed in this study is subject to the following licenses/restrictions: data sharing on request to corresponding author after Ethics Committe approval. Requests to access these datasets should be directed to Jean-Baptiste Lascarrou, amVhbmJhcHRpc3RlLmxhc2NhcnJvdUBjaHUtbmFudGVz The studies involving human participants were reviewed and approved by Commission Nationale Informatique et Libertés n°2217488 Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements Médecine Intensive Réanimation Unités de soins intensifs CHU Ambroise Paré Department of Intensive Care,CHR Mons-Hainaut Réanimation médico-chirurgicale CHU Avicennes Unités de sois intensifs CHU Ambroise Paré Réanimation polyvalente Center Hospitalier du pays d'Aix Assistance Publique-Hôpitaux de Marseille Service d'anesthésie-réanimation chirurgicale Unité de réanimation chirurgicale polyvalente Hôpitaux Universitaires Henri Mondor Réanimation - Médecine Intensive Service de Médecine Intensive Réanimation Groupe des anesthésistes réanimateurs Hôpital Privé d'Antony J-BL and DG were responsible for the study concept and design and DG: analysis and interpretation of the data and drafting of the manuscript critical revision of the manuscript for important intellectual content and read and approved the final manuscript The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication JT is a part-time employee of bioMérieux The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest We thank Mariana Ismael for Castor EDC (Amsterdam The Netherlands) for technical support in designing the eCRF The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2021.632933/full#supplementary-material Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan Risk factors associated with acute 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Sauneuf, Piagnerelli, Ly, Lejeune, Lefebvre, Hraiech, Horlait, Higny, D'hondt, Gaudry, Courcelle, Carbutti, Blonz, Ottavy, Aissaoui, Vinsonneau, Vandenbunder, Textoris, Szychowiak, Grimaldi and the COVADIS study group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Jean-Baptiste Lascarrou, amVhbmJhcHRpc3RlLmxhc2NhcnJvdUBjaHUtbmFudGVzLmZy; David Grimaldi, ZGF2aWQuZ3JpbWFsZGkyMDAxQHlhaG9vLmZy Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Joskin invited the Irish Farmers Journal over to its headquarters in the town of Soumagne in Belgium to visit two of its production plants and learn a bit about the business Company founder Victor Joskin started life as an agricultural contractor 600 dealers across 60 countries and has built over 130,000 machines to-date The growth of Joskin is hugely impressive when you consider it’s still wholly owned and run as a family business Victor Joskin carried out work for local farmers where the main tasks were spreading slurry and muck Victor moved the business into servicing and repair of machinery and two years later in 1974 he started to import machinery into Belgium Not overly happy with the machines then available on the market to spread slurry Victor looked into building his own slurry equipment The company’s first slurry tanker was built in 1984 he also bought a company building grass aerators which remains an important product for Joskin today Joskin specialises in farm transport vehicles – notably slurry which is then complemented by grassland equipment Joskin has five production facilities across Belgium including a state-of-the-art galvanisation plant in Poland The family business employs 870 staff across its sites Joskin builds in the region of 2,200 tankers and 1,600 trailers each year The company galvanises 70-80% of what it produces Slurry tankers account for 45-50% of production The remaining 10% is made up of smaller products Joskin’s slurry tankers are built in Soumagne and in Trzcianka in Poland before being expanded in 2010 with an 8,000m² galvanising plant Close to Joskin HQ in Soumagne is the Spawtech plant where welding and tack welding ahead of final construction take place Joskin added a site in northern France when it acquired the LeBoulch trailer brand Joskin recently began construction of a new factory in Luxembourg The firm said Luxembourg was chosen based on the site location in addition to an available is scheduled to be commissioned in Q3 of 2025 It will house the assembly of large trailers and a range of muck spreaders Joskin acquired French muck spreader and trailer company LeBoulch Joskin has just invested in a new building to include welding workshops automatic shot-blasting and a painting area “Theres no Friday evening or Monday mornings with robotic welders,” laughs Jean-Marc This will add 40% more production capacity to the site Joskin’s aim is to double the number of LeBoulch trailers and spreaders produced annually with plans to grow the brand’s presence in European markets the site manufactures Joskin bale trailers and its hook-lift trailers Joskin feels that the fact it remained a totally owned family business rather than answering to a board of shareholders allows it to react to the customer quicker and make investment decisions based on what’s best for the company long term but is more involved in the future of the business Vinciane and Murielle hold key positions within the business his sister Vinciane is over administration and finance and other sister Murielle is over company communication and human resources its headquarters at Soumagne and the nearby Spawtech plant The HQ state-of-the-art 17.1ha (42.2ac) site holds 2,400t of sheet steel at any one time Joskin offers more than 900 options across its slurry tanker range alone with a staggering 120 different tyre options and about €2m worth of tyres in stock at any one time A lot of the equipment Joskin manufacturer is custom-built to order a new tanker or muck spreader is given an ID number and spec list which follows it through the manufacturing and assembly process The Joskin group use a centralised computer system across all its production sites which allows precise management of the whole production process in real time Joskin explained that to stay competitive on pricing and to create efficiencies of scale within the factory This range works off a standard specification Electro-hydraulics are manufactured in-house Lead times vary from standard machines such as the Advantage series which may be in stock up to 16 weeks for its Modulo tanker range It said that it sells tankers to 60 countries Joskin’s investment into production is evident one hall is dedicated almost entirely to lathes These are complemented by a measuring robot Various parts of the production chain have been automated Joskin uses laser cutters which can cut steel up to 25mm in thickness automated saws and a fully automated press brake using jigs that the company has built itself with manual welders handling smaller tasks before the robotic welders take on the main welding Joskin sees the benefit in investing in making production more efficient it recently added two robotic welders which only weld trailer bodies The company said that welding 8m tri-axle trailer bodies that once took three days of manual welding is completed in seven hours with one robot Joskin typically use around 1,500t of steel each month two fully automated positive and negative folding presses Joskin manufactures 85% of the components it uses in-house It even builds its own hydraulic rams (apart from trailer tipping rams) Joskin prides itself on making as much of its own parts as possible and it even manufactured parts for Mercedes Benz for a while Joskin says that in order to keep control over quality and stock levels These pieces were produced by a 3D printer measuring and reproducing componentry down to one micron Part of this investment saw the firm recently purchase a 3D scanner and printer Joskin claims this gives huge flexibility to design and print prototype parts for production This piece of technology is capable of measuring and reproducing componentry down to one micron a single average human hair is around 100 microns in size Muck spreaders make up about 8% of total production Joskin’s main plant has 8,000 solar panels When there isn’t a demand for power from the plant “There is this stigma out there that galvanising costs much more than painting – this isn’t necessarily true there is very little between painting and galvanising,” explained export manager Jean-Marc Vanempten Joskin products are known worldwide for their galvanised finish All tankers made in Belgium are galvanised in Belgium all parts and componentry are galvanised in its Polish plant Joskin claims that it has the capacity to galvanise twice as much kit as it currently is doing It’s then coated with a mixture of steel and zinc The outer galvanisation coat isn’t as hard and absorbs the shocks Painted components are shot-blasted and electrically charged Joskin says this is for better adhesion when spraying with an initial layer of epoxy primer and final layer coat Painted components such as axels and pumps are then fitted to the galvanised body Slurry is Joskin’s bread and butter product Its most popular size tankers are tandem axle The tanker barrels are fabricated at the Spawtech facility 4-6mm S420 grade steel is rolled into the barrel shape and tack welded with a six-metre-long tank using two baffles It takes three hours to tack weld a standard tanker with the internal tank then completely robotically welded in 90 minutes “There are no Friday evening or Monday mornings with robotic welders,” laughed Jean-Marc The firm patented its first macerator design in 1990 and today offers six variations of slurry pumps spiral pumps 10% and its hybrid Vacu-Storm pump accounts for the remaining 10% The Vacu-Storm pump is a hybrid system developed by Joskin seven years ago It combines the advantages of a vacuum pump on the suction side and a Storm centrifugal pump on the discharge side Joskin says Vaccum pumps are limited to a working width of 12m The 13,000l Jurop pump is integrated in the drawbar and is used for suction The Storm centrifugal pump (10,000 l/min) is designed to feed the rear implement and allows spreading over larger widths and with a high and constant flow rate One-point Joskin really wanted to get across was that it is no more expensive than other manufacturers Didier Joskin acknowledged that Joskin has a reputation for being expensive something the company feels isn’t the case “I think when you look at what you get with a Joskin tanker we’re actually very competitive because a lot of features that would be options with other brands are included as standard with us.” In an effort to break the stigma around this and make the brand even more competitive on price Joskin introduced the Advantage range in 2019 This is now available on the majority of its product offering with the idea to standardise the general build of machines Much of this kit can be then fitted with some of the 900+ options before completion between 70 to 80% of the tankers sold are Advantage models a 2,500-gallon Advantage tanker with a 7.5m trailing shoe with a complete integrated electro-hydraulic system with control box is priced at €42,000 plus VAT Victor Joskin set up his own machinery retail business in 1973 The firm is a Fendt and Massey Ferguson dealer a JCB sub dealer and import and distribute eight brands across Belgium The manufacturing site and retail side of the business share a 13m-high the machine will shift the shelves around itself automatically with future investments planned for France with the new Luxemburg plant to open in 2025 This 2,500-gallon Advantage tanker with a 7.5m trailing shoe with a complete integrated electro hydraulic independent with control box is priced at €42,000 plus VAT slurry tankers might drop from 45% to 30% of our total production I think that the future for slurry tankers will be less machines but larger tankers with higher specification Contact us Advertise with us Company information Career opportunities Privacy statement Terms of service Commenting policy Change cookies settings Change cookies settings Metrics details as it has been shown that the induction of autophagy may promote longevity the authors have suggested a relationship between the increased level of this potential biomarker of autophagy and the exceptional longevity of these patients non-smokers n = 95) of the 301 patients for whom a serum sample was available we performed a quantitative evaluation of circulating Beclin1 protein level (ELISA Kit for Beclin1; cat Descriptive results are given as numbers and percentages for categorical data and means (±standard deviation) for continuous variables Unadjusted comparisons of Beclin1 levels between study groups were conducted using one-way ANOVA for overall significance and post hoc t-tests for pairwise comparisons applying Sidak correction for test multiplicity Linear regression was used to compare Beclin1 levels across the three groups while adjusting for age Associations between Beclin1 and biological parameters were assessed by computing Pearson correlation coefficients All analyses were performed using Stata 14.1 (StataCorp with each box representing the interquartile range (1st to 3rd quartile the line within the box indicating the mean and the whiskers extending to 1.5 times the IQR above and below the box; the dots represent individual values for each patient Beclin1 circulating levels decline might also participate to autophagy impairment during COPD It now seems necessary to further investigate its potential regulatory role in the process of accelerated aging associated to chronic cigarette smoke exposure and COPD although our results need to be confirmed in other cohorts of COPD patients or with other potential biomarkers of autophagy they support the hypothesis of a relationship between autophagy deficiency and COPD pathogenesis They also incite to refine our knowledge on the complex mechanisms linking defective autophagy and cellular senescence in the progressive pathogenesis of COPD and of its systemic manifestations Systemic manifestations and comorbidities of COPD Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease Lactosylceramide-accumulation in lipid-rafts mediate aberrant-autophagy inflammation and apoptosis in cigarette smoke induced emphysema Role of cigarette smoke-induced aggresome formation in chronic obstructive pulmonary disease-emphysema pathogenesis Master autophagy regulator transcription factor EB regulates cigarette smoke-induced autophagy impairment and chronic obstructive pulmonary disease-emphysema pathogenesis Augmenting autophagy for prognosis based intervention of COPD-pathophysiology Can enhanced autophagy be associated with human longevity Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians Aging-related systemic manifestations in COPD patients and cigarette smokers Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1 Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease Autophagy and senescence: a partnership in search of definition Role of autophagy in COPD skeletal muscle dysfunction Bcl-2 family members: dual regulators of apoptosis and autophagy Download references We gratefully acknowledge Lucie Bizard for helping to perform the ELISA Elisabeth Marcos for the management of telomere length measurements Institut Mondor de Recherche Biomédicale and Université Paris Est-Créteil (UPEC) Département de Physiologie-Explorations Fonctionnelles Département de Pneumologie et Pathologie Professionnelle The authors declare that they have no conflict of interest Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41419-017-0178-1 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Cellular and Molecular Neurobiology (2023) You are using an outdated browser. Please upgrade your browser or activate Google Chrome Frame to improve your experience Belgian PV product distributor Ecostal has acquired Project Zero a business-to-business specialist in Flanders It did not disclose the financial terms of the deal Belgian PV product distributor Ecostal said this week that it has acquired Project Zero for an undisclosed sum “The aim of this transaction is to constitute a solid group able to face the many upcoming challenges and to bring maximum value to professionals in the photovoltaic energy sector and the Netherlands,” the company said in a statement “Welcoming Project Zero within our group is a real opportunity to serve all installers in Belgium more effectively,” said Ecostal CEO “Our networks are complementary and the strong presence of Project Zero in Flanders will allow us to constitute a leading group in Belgium.” More articles from Emiliano Bellini Please be mindful of our community standards and website in this browser for the next time I comment Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" By submitting this form you agree to pv magazine using your data for the purposes of publishing your comment Your personal data will only be disclosed or otherwise transmitted to third parties for the purposes of spam filtering or if this is necessary for technical maintenance of the website Any other transfer to third parties will not take place unless this is justified on the basis of applicable data protection regulations or if pv magazine is legally obliged to do so You may revoke this consent at any time with effect for the future in which case your personal data will be deleted immediately your data will be deleted if pv magazine has processed your request or the purpose of data storage is fulfilled Further information on data privacy can be found in our Data Protection Policy Δdocument.getElementById( "ak_js_2" ).setAttribute( "value" This website uses cookies to anonymously count visitor numbers. 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about 110km of steel is stored The parts carousels deliver parts to assembly Joskin has developed this factory into a state-of-the-art production centre almost all tasks are carried out at the factory They are unique to every customer as they all want something different There are over 3,000 parts in the average Joskin tanker This is exciting for design as we can always focus on the customer’s needs Every Joskin tanker will have its own unique parts manual delivered with the machine The local dealer will also have access to this information Machinery has always got bigger since I started in this industry It is also very important to look at technical performance The machine again must suit what the customer wants If there is a premium to be paid for that product it will probably be worth it in terms of performance and reliability over the life cycle of the machine Joskin machines have a very long life cycle so they are a good investment What difficulties do you see in this industry over the coming years some farmers could farm their lands without having to change their machine in 10 years or more This makes us vulnerable as manufacturers if farmers decide they don’t want to change machines anymore Are there any new markets opening up for Joskin The machines required are small to meet their needs Getting into new countries is hard and has a high demand on resources – at least three staff work on the administration alone I believe that there is more potential for our products in Ireland too No this will not happen; we can paint over the galvanised finish when required We want our tanks to last and this process is a must in my view for quality and longevity of the machines How do you see farming going in the next 10 years Probably more dairy farmers and livestock farmers This will increase the demand for feed such as maize and silage slurry will need to be managed and there will be lots of it Our machines can help with the transport of forage to farms and applying the nutrients back to the land They maintain them well – they’re good at producing milk and good with their machinery Will there be any new products from Joskin next year We have a broad range of equipment at the moment What we will concentrate on is our muck spreader range We are working on spread patterns and evenness of application This is important for the farmer to accurately apply muck across the fields for good growth of crops afterwards We also believe that training for our local dealers is vital to maintain good relationships with our end user I still prefer to sell many small machines rather than just once-off big machines