Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. Canada’s Russell Bowie and Margaux Brejo of France have both claimed maiden World Deaf Golf Championship titles in dominant fashion at RACV Royal Pines Resort on the Gold Coast. Runner-up in Hawaii two years ago, Bowie was 6-under through 11 holes in the final round on Thursday before signing for a 4-under 68 and five-stroke win over defending champion Nico Guldan (74) of Germany. Brejo began the final round of the women’s event with a seven-stroke advantage and although defending champ Vanessa Girke of Germany recorded two early birdies, Brejo was never seriously threatened. The third-place finisher in Hawaii converted eagle chances after driving the green at both the par-4 sixth and par-4 10th in a round of 3-under 69 for a 7-under total and 11-shot victory. For Bowie, an accomplished amateur golfer in Ontario, his Australian triumph represents the high point of his golf career. “As golfers, we don’t win hardly ever. You lose the vast majority of your tournaments so a win of any kind is very, very special,” said the 32-year-old. “I’ve never really won something really high level so this is probably about top of the list. Especially playing against Nico, a very good competitor, very good golfer. “It’s definitely something I’m proud of and I’ll always remember very fondly.” He can now also lay claim to having won at the same golf course as his idol, Adam Scott, the 2019 Australian PGA champion at Royal Pines. “I know Adam Scott won from about 600 yards further back, but this is a very good test,” said Bowie, who had rounds of 79-67-70-68 for a 4-under total. “Playing under par here for the week is something I’m very proud of, especially after the start I had.” Verbally committed to attend Georgia Southern University in the US from 2025, Brejo was proud to accomplish the objective she set for herself at the start of the week. “It’s a title I will always remember in my life,” said the 17-year-old. “It’s been a great week and I really like being in Australia and with all the good players. “I play 3-under today which was very important for me and I think I won by nine or 10 shots. “This is very incredible for me and proved to myself I can be better and I can be the best. “From my professional life and everything going after, it’s good.” Supported by The R&A, World Deaf Golf Federation President Simeon Hart hopes that the success of the 2024 Championships in Australia will lead to an increase in participation ahead of two major events to follow in the next two years. “We are absolutely thrilled with the success of this tournament and wish to thank the City of Gold Coast and Golf Australia for hosting us this week,” Mr Hart said. “It is our hope that deaf people of all ages interested in playing golf will be inspired to start playing and to enter future deaf golf championships. “We have the Deaflympics in Tokyo in November 2025 and, in August 2026, Barseback Resort in Sweden will host the World Deaf Golf Championships. “We know that there are other talented golfers out there and we would love for them to join us in the years to come.” It was a double win for Brejo who also claimed the Junior Women’s event as India’s Vibhu Tuagi won the Junior Men’s event. The Australian Men’s team and Senior Men’s team both finished second to Canada and the United States respectively as the US claimed the Women’s Team event from Germany and England. Get weekly updates on news, golf tips and access to partner promotions. Join our newsletterGet weekly updates on news, golf tips and access to partner promotions! Promising French teenager Margaux Brejo adopted the mindset she knows is needed to pursue a career in professional golf to open up a seven-shot lead in the women’s event of the World Deaf Golf Championships at RACV Royal Pines Resort The decision to hit driver off the deck for her second shot led to an eagle at the par-5 third in Round 3 putting Brejo on the path to a round of 5-under 67 and a handy buffer over defending champion Vanessa Girke (74) of Germany kept his hopes of going back-to-back alive with a round of 2-under 70 Canadian Russell Bowie (70) trailing by one after two late bogeys in his round of 2-under 70 On a day in which both Australian Jack Besley and American Ashlyn Johnson holed out for eagle at the par-4 11th it was Brejo’s aggressive play midway through her round that separated her from the field was 3-under on her round shortly after they made the turn Brejo taking the tournament by the scruff of the neck with her bold decision to set up eagle Margaux will play 4-wood or she will play driver on the deck and I say “I play driver on the deck and I have maybe 35 metres to the pin Verbally committed to attend Georgia Southern University in 2025 Brejo said it was important to play in the manner she will need to one day turn professional “The step now is to be a leader,” Brejo added “I’m trying to have a professional mind and just think that you can do the best Girke dropped three shots in her final three holes in Round 3 and knows it will take something special to win a second straight World Deaf Golf title bogey and then the last birdie putt on nine lipped out It was a late switch at the top of the leaderboard in the men’s event as Bowie dropped from one in front to one behind after failing to get up-and-down at both 17 and 18 I had caught Nico on the leaderboard,” said Bowie “I would’ve been one ahead of him and then now just going in still one behind kind of where we started the day basically Guldan was a nine-stroke winner over Bowie at the 2022 World Deaf Golf Championships in Hawaii the Canadian ready to make it more of a contest on the Gold Coast “I was never really as close as I am now to the lead,” said Bowie who will stay on in Australia to play the Melbourne Sandbelt at the completion of the tournament “He played really well then and he’s playing really well now “It’s kind of familiar territory for us playing together so looking forward to having another round tomorrow.” Hopes for any Australian success on home soil now rest in the team’s events with the senior men’s team to start the final round in second position six strokes behind the Canadians while the USA have a large lead in the women’s teams event with one round to play Round 3 scores golf tips and access to partner promotions Join our newsletterGet weekly updates on news ← → Algacir Schadeck snaps a fat ear of corn off a dry corn stalk in western Bahia one of Brazil’s leading grain-producing regions he’s standing at the edge of a field more than half a mile across that bears 1,000 tons of corn As the manager of Fazenda Rio Claro farm and the descendent of a long line of farmers he pronounces the pumpkin-orange kernels perfect The water that feeds this farm is pulled from the nearby Arrojado River and sprayed over the fields using pivots — long pipes propped up on wheeled frames that rotate around a central point as they spray — each consuming millions of gallons every year Fazenda Rio Claro’s pivots shower its crops with more than 500 million gallons of water annually more than is used by the residents of Correntina Wetlands have dried up; crops have failed; many subsistence farmers are struggling. But the question of why Brazil is drying up is complex. Much of the country has experienced reduced rainfall over the past two years. This year, southern and central Brazil are experiencing their worst drought in nearly a century has altered water flows both above and below ground climate change is inexorably increasing evaporation Subscribe to the E360 Newsletter for weekly updates delivered to your inbox. Sign Up who have lived in western Bahia for generations say they have little doubt what’s causing the declines in water that they’re experiencing: They blame pumping by large-scale industrial farms for robbing them of water they need to slake the thirst of their manioc Scientists studying the region agree that rivers are ebbing But they disagree about whether pumping by corporate farms is the primary culprit and whether it makes sense to keep pumping more “I planted these coconut trees and they died.” The name of his village This has recently become a cruel irony for the 150 or so geraizeiro families that live there Now the spring produces only enough for cooking they installed a plastic pipe to carry the water where spindly drought-tolerant trees and dense shrubs stretch beyond the pasture “I’m thinking that we’re going to get wet,” says dos Santos as the soil turns squishy beneath his feet But his sandals are barely damp by the time he and Brito reach the shallow pool where the spring seeps up from the mud They pry the lid off a shoebox-size cement box that feeds the pipe and peer inside “I’ve never seen it this way,” says Antonio Researchers have not yet come to Brejo Verde. But their work across western Bahia’s plateau is aiming to determine what is happening to the water in rivers and springs throughout the region, many of which are running dry In early 2020, a team at São Paulo State University published a study of the Urucuia aquifer — a huge underground reservoir that underlies western Bahia’s plateau This aquifer is the source of all of region’s surface water during the long dry season and it’s the primary headwater of the São Francisco River the fourth longest river in South America and a major supplier of hydroelectric power A movement grows to help farmers reduce pollution and turn a profit. Read more is only a small fraction of the aquifer’s estimated 290 cubic miles of water Groundwater users — primarily the farms with pivots — will have plenty of water for far into the future is how the loss is affecting surface water Depletion of the aquifer might explain the dwindling spring in Brejo Verde, says Chang. “My suspicion is that probably a small drop in the groundwater will affect the spring water,” he says. Such effects have been noted in research reports before Kiang has asked Gonçalves to build a mathematical model of the aquifer that could relate declines in the water table to specific changes in surface water an effort that he says could be completed in the coming months but experts agree that river flow and aquifer levels are declining Determining what is causing those changes has important policy implications It holds the key to forecasting the future of water supplies which wends 1,800 miles through five states and supplies 10 percent of Brazil’s electricty And it begs the potentially politically explosive question of what or who is to blame Most water experts agree that a reduction in rainfall and the growth of big commodity farms have both played a role “We have no definitive answers,” says Chang Rainfall in western Bahia increased starting in about 1980, but since the early 1990s it has slowly been dropping, leading up to the recent drought. Compared to the 1980s, the period since 1993 has been 12 percent drier Marques says “a decade of rain decline” is likely the primary cause of water depletion in the region president of the Brazilian Cotton Producers Association the certainty is that it is due to the decrease in rainfall in the last three or four years,” he says But Chang and Gonçalves dispute this conclusion “This is not about rainfall,” Gonçalves says The GRACE satellites measured a huge loss of water during a 12-year period during which rainfall didn’t decline at all “The only way we can explain this drop is by extraction [for irrigation],” says Chang Farms in western Bahia require state licenses to pump water and he suspects that a lot of pumping from wells and rivers “is underreported or not reported.” an atmospheric scientist who is Marques’s colleague at Universidade Federal de Viçosa When asked if farming or rainfall decline are robbing more water from western Bahia he said: “I think they are equally important.” Costa and Marques agree that no more pivots should be built in the most densely irrigated parts of western Bahia such as parts of the Grande River watershed the largest of western Bahia’s three basins No more groundwater can responsibly be withdrawn there But they say there is still room for growth elsewhere on the plateau This is a welcome message for the cotton and grain farmers The Association of Farmers and Irrigators of Bahia forecasts that the amount of farmland on the plateau will grow by 60 percent over the next decade Many geraizeiros feel there is already enough evidence that the commercial farms are robbing them of water says “agribusiness should be forbidden” on the plateau Geraizeiro anger has already led to conflict a few hundred geraizeiros arrived at Fazenda Rio Claro In a riot that’s been called the “Water War,” they torched combines An illicit trade in Brazil is sending tiny songbirds to their deaths. Read more Daniel Grossman is a journalist and radio and web producer who has reported from all seven continents. He is the author of Deep Water: As Polar Ice Melts, Scientists Debate How High Our Oceans Will Rise. More about Daniel Grossman → Never miss an article. Subscribe to the E360 Newsletter → Pope Francis envisages Catholic schools as “welcoming places” where one heals not only one's own wounds but also those of others.  He wants them to be places where one learns to read and discern the "signs of the times" he wants them to help develop in their students a critical attitude towards certain models of development and consumption that create shameful inequalities among people The Pope expressed his vision of an ideal Catholic school in a message he sent on Thursday to the Latin American Federation of Jesuit Schools (FLACSI) the federation of some 92 Jesuit-run schools in 19 countries of Latin America and the Caribbean  FLACSI was started by the Conference of Provincials for Latin America (CPAL) strategies and initiatives across the network in the service of education and the social transformation of the region.  invited FLACSI schools to "go out" following the example of Jesus "who teaches us to relate to others and to Creation"  He particularly insisted on “meeting with the little ones  "May our schools form hearts convinced of the mission for which they were created with the certainty that life grows and matures to the extent that we give it for the life of others".  Instead “life which is preserved ends up being a museum piece smelling of naphthalene Hence “welcoming schools” should really have open doors where the poor can enter and where others can go and meet them.  Schools should embody the wisdom of the Gospel which is the privileged perspective from which one can learn so much should not withdraw into “selfish elitism” but must be places where students “live together with everyone knowing that everything is connected.”  In this regard the Pope said one should remember that “fraternity it is the “objective identity of the human race and of all creation” by which “we are created in a family The Pope also hopes that FLACSI schools "teach to discern to read one's life as a gift to be grateful for and to share".   He hopes that they “have a critical attitude on development which frenetically push towards a shameful inequality that makes the great majority of the world population suffer”.   “As you can see my desire is that your schools have a conscience and create consciences,” the Holy Father said urging FLACSI members to be “disciples and missionary schools” Thank you for reading our article. You can keep up-to-date by subscribing to our daily newsletter. Just click here Ecotoxicology and Environmental SafetyCitation Excerpt :This work has the purpose of determining whether the ecotoxicological indicators can complement the classical biological indicators (as indices of abundance and composition of phytoplantonic communities) (Martinez-Haro et al. this integrative approach of the individual and subindividual responses may allow for an improvement in the capability to determine ecological status closing the gap between ecology and chemistry and the gaps between the results from laboratory experiments and field observation (Palma et al. The main objective of this work was to investigate the contribution of bioassays using a model organism and representative species of freshwater ecosystems (Dapnhia magna) and integrating bioindicators (bioassays and biomarkers) to the assessment of the potential ecological status of four Portuguese reservoirs (Miranda All content on this site: Copyright © 2025 Elsevier B.V. Picture by 2020 Getty ImagesBy Aarish AnsariTokyo 2020 Olympian Diksha Dagar won the gold medal in the women's golf event at the ongoing Deaflympics 2021 in Caxias do Sul It is an upgrade for the 21-year-old Diksha who had won a silver at the previous Deaflympics in 2017 left-handed Diksha Dagar defeated Ashlyn Grace Johnson for the gold with a 5 and 4 in the final of the match play segment meaning the Indian was leading by five holes with four holes remaining The bronze went to Margaux Brejo of France The Indian golfer had been in impressive form throughout the event topping the stroke play round with a score of 67-72 over 36 holes (two rounds of 18 holes) and reaching the quarter-finals Diksha Dagar ousted Germany’s Amelia Paloma Podbicanin 6 and 5 in the last eight before beating Andrea Hellegjerde 5 and 4 in the semis The young Olympian, who turned pro in 2019, has won twice on the Ladies European Tour – once as an individual in 2019 and as a team in 2021. Teenage Frenchwoman Margaux Brejo has symbolically put her country on her shoulders to take the Round 1 lead at the World Deaf Golf Championships on the Gold Coast A field of 104 players from across the globe teed off at RACV Royal Pines Resort on Monday morning Brejo leading the women’s event with a round of 1-under 71 as defending champion Nico Guldan of Germany also shot 71 to lead the men’s event by two Brejo has a three-stroke lead from defending champion Vanessa Girke (74) with American pair Erica Pressley (78) and Ashlyn Johnson (79) third and fourth respectively In the crowd for the final day of the men’s Olympic golf competition and day one of the women’s competition at Le Golf National earlier this month Brejo has adopted her own method to display national pride “I think I’m the only player who takes my bag on my shoulder and it gives me a difference because I think I have my country on my shoulders,” said Brejo and I’m a little bit superstitious about that.” Playing off plus-4 at Fontaineblau Golf Club an hour south of Paris 17-year-old Brejo was fourth at the 2022 World Deaf Golf Championships in Hawaii She made a terrific start to the 2024 championship with birdies at 13 and 17 to turn in 1-under Brejo made bogey after almost driving the green at six three-putted eight for par after driving the green but closed with birdie at the par-5 ninth to take momentum into day two “That was the most important for me,” Brejo said of her closing birdie “On the eighth I take the green in one and I take three putts on the sixth I make a chip and three putts and seven I take the green in one and make three putts so nine was the most important for me to feel positive for the next round.” Girke made double-bogey on the ninth to hand her a three-shot deficit heading into Round 2 “I’ve had some back pain the last few weeks and a bit struggle with my swing so I’m pretty happy that today it was pretty good.” As defending champion and with experience playing the ProGolfTour in Europe Guldan began the championship as the man to beat three and eight he raced out to an early lead but made three bogeys on the back nine to end the day 1-under and two strokes clear of Australian Jack Besley Playing off plus-4 at Heilbronn-Hohenlohe Golf Club in Germany Guldan struggled to maintain his rhythm on the back nine and stay on good terms with putting surfaces very different than what he is used to He is well placed to go back-to-back but is viewing this championship as something of a free hit but I go with the mind game that I already have one title so I don’t have to I will go to train after this a little bit and then I hope I can defend it.” Winner of the Australian Deaf Golf Championship at Royal Pines last September Besley has his eyes on a second World Deaf title 10 years after his first The Assistant Course Superintendent at Southern Golf Club in Melbourne Besley birdied 16 and 17 before dropping a shot on 18 in his round of 73 “I learned what not to do on a few tees,” Besley said of the knowledge he took from his victory at Royal Pines 12 months ago “Instead of just going guns blazing with the driver kept it in play and sort of reflected a little bit on the score as well.” Dunedoo’s Chantell Greaves is the best-placed Australian in the women’s event the reigning Australian champion tied for 10th after a difficult finish to her first round Round 1 scores by Ryan Gilliam LinkGearbox Software/2K Games via PolygonRyan Gilliam (he/him) has worked at Polygon for over eight years. He primarily spends his time writing guides for massively popular games like Monster Hunter, Diablo 4 & Destiny 2.Here are all of the Borderlands 3 Ambermire challenge locations on Eden-6. Check out the completed area map below, as well as individual images for each challenge location. There are several challenges in most of Borderlands 3’s maps. These challenges reward great experience and sometimes even enhance your vehicles. Picking them up is always worthwhile, but some of them can be a real pain to find. And that’s why we found them for you. Look for the small, gray icons on the map above to find the challenges in Ambermire. Next1/5Gearbox Software/2K Games via PolygonOn the left side of the map, you’ll run into a very tall building. Walk around back and climb the ladder. Crouch and jump your way through the path until you reach the top. Deactivate the Crimson Radio beacon. Next1/4Gearbox Software/2K Games via PolygonOn the right side of the map, you’ll find a complex with giant pipes running in the sky. Follow the pipes from the start of the area to the back and find a place you can jump up. Climb up onto the roof and follow the pipe to reach the building with the Crimson Radio tower on it. Next1/2Gearbox Software/2K Games via PolygonOn the left side of the map, you’ll find a Claptrap gummed up in some webs attached to a building. Next1/2Gearbox Software/2K Games via PolygonOn the far left side of the map, in an open area, you’ll find the second Claptrap sitting against a broken storage container. Next1/2Gearbox Software/2K Games via PolygonNear the open area, you’ll find a waterfall with a cave behind it. Approach the area to start the fight. Next1/2Gearbox Software/2K Games via PolygonIn the middle of the map, you’ll find a bog-like area. Near a small lake is a dock, and on that dock is the first Typhon Log. Next1/2Gearbox Software/2K Games via PolygonYou’ll find the second Typhon log on the right side of the map. It’s sitting next to some foliage. Next1/2Gearbox Software/2K Games via PolygonThe final Typhon Log is on a wooden deck near the second Crimson Radio tower on the right side of the map. Next1/2Gearbox Software/2K Games via PolygonThe Typhon Dead Drop is far into the left path. You’ll find a small town near a bay. Jump off the wall and into the water. Turn around and the Dead Drop is leaning against the wall. The best of Polygon in your inbox, every Friday. Discovery of a mutation that mitigates muscular dystrophy in dogs and identification of human genes linked to rare diseases researchers at the Human Genome and Stem Cell Research Center (CEGH-CEL) associated with the Biosciences Institute of the University of São Paulo (IB-USP) had some type of molecular mechanism that mitigated the appearance of the more severe symptoms of muscular dystrophy such as trouble with walking and swallowing as what would later be the case with his pup Suflair an essential protein for maintaining muscle integrity and should have succumbed to the disease’s progressive degeneration after having lived a normal lifespan for dogs and Suflair continues to be healthy at age nine and a half in partnership with colleagues from Harvard Medical School and the Broad Institute in the U.S. published an article in the journal Cell that explains the phenomenon:  the two golden retrievers present increased expression (activation) of the Jagged1 gene that protects them from developing the severe symptoms of muscular dystrophy The finding is promising because scientists believe that it signals the possibility of exploring a new therapeutic approach that could at least mitigate the symptoms of the disease in humans by controlling the function of this gene The newly discovered genetic alteration causes the Jagged1 levels to be two times higher in Ringo and Suflair than in dogs severely affected by the disease the gene is activated more intensively and produces twice the respective proteins in the USP dogs than in the sick animals the anomaly in the Jagged1 gene compensates for the harmful effects of the absence of dystrophin caused by mutations in the gene responsible for producing that protein This is because one of the functions of the Jagged1 gene is to act on an intracellular signaling pathway called Notch which is involved in producing and repairing muscle cells Eduardo CesarThe dogs Ringo and Suflair: mutation in the Jagged1 gene mitigates symptoms of the diseaseEduardo Cesar “We’ve been able to show for the first time that a large animal can have functional muscle without dystrophin,” says Mayana Zatz coordinator of the recently-published study and of the CEGH-CEL Innovation and Dissemination Centers (RIDC) funded by FAPESP “The paper paves the way for us to test new treatments against the muscular dystrophies that are most commonly seen in humans through increased activation of the Jagged1 gene.”  Current therapeutic approaches to muscular dystrophy that for now show only modest results focus on trying to restore normal function to the dystrophin gene whose mutations interrupt the production of this protein and lead to the appearance of the disease Both forms of muscular dystrophy—the more severe de Becker—are recessive diseases that primarily attack males There is a simple explanation for this pattern of occurrence The dystrophin gene is located on the X chromosome of which males have one copy and females have two That is why males develop the disease by inheriting a single copy of the mutated gene while females need to have two copies with the alteration in order for muscular dystrophy to manifest itself in most cases are asymptomatic but during pregnancy have a 50% chance of transmitting the gene to their offspring Duchenne muscular dystrophy affects one out of every 3,500 newborn males a rate 10 times higher than that of de Becker As an early clue for where to look for the hypothetical protective mutation Vieira used data from an experiment conducted five years ago in collaboration with the laboratory of Sergio Verjovski-Almeida we saw that 66 genes had an altered expression profile in the asymptomatic dogs compared with the affected animals,” says Verjovski-Almeida Vieira performed whole-genome sequencing on Ringo Suflair and a third golden retriever with a severe case of muscular dystrophy She discovered that there was a small mutation in one of the 66 genes that had caught their attention in the IQ-USP study: a change in a single nitrogenous base (the chemical unit of which all DNA is composed) in the region that regulates the Jagged1 gene function was the mutation they had sought for years The biologist then returned to Kunkel’s laboratory and ran experiments with messenger RNA in zebrafish one of the biological models most often used to simulate human diseases in animals by stimulating activation of the Jagged1 gene as it occurs in the dogs whether the fish would present a lower prevalence of a condition equivalent to muscular dystrophy in humans “The incidence of the disease fell from the expected 25% to 6%,” says Vieira the researchers collected strong evidence that the mutation in the Jagged1 gene is capable of attenuating the clinical manifestation of muscular dystrophy Advances in rare diseases Identification of a likely molecular mechanism mitigating the development of dystrophies was not the only recent achievement by CEGH-CEL to produce significant findings towards understanding genetic diseases In an online article published September 29 2015 in the journal Human Molecular Genetics another group of researchers associated with the USP center showed that patients with a rare hereditary neurodegenerative syndrome do not present a 216 base pair sequence in the region that controls the function of the KLC2 gene on chromosome 11 It took 10 years to identify the genetic alteration while doing a post-doc fellowship at the CEGH-CEL São Paulo biologist Silvana Santos was the key player in discovery of the disease in Serrinha dos Pintos a town of 5,000 inhabitants in interior Rio Grande do Norte State where one-third of all marriages were consanguineous meaning between two individuals who are related as second cousins or closer We were only successful because we were able to use new sequencing techniques,” Mayana Zatz says Reproduction of the cover of the Book Brazil and the Dutch – 1630-1654Rua dos Judeus, in 17th century Recife: the mutation that causes SPOAN syndrome likely came into the Northeast at the time of Dutch Brazil with the arrival of Sephardic JewsReproduction of the cover of the Book Brazil and the Dutch – 1630-1654 Eduardo CesarSerrinha dos Pintos: SPOAN disease was discovered in 2005 in a town in rural Rio Grande do Norte StateEduardo Cesar UIRÁ MELO Zebrafish embryo: (from left to right) normal slightly affected and highly altered by the SPOAN mutationUIRÁ MELO occurs as a result of a mutation identified in the Inositol monophosphatase 1 (Impa1) gene located on chromosome 8 It is a disease that causes intellectual disability and behavioral changes such as agitation and aggressiveness It was discovered in nine members of a family from Brejo dos Santos “This work offers an interesting perspective to our studies,” says neurologist Fernando Kok a CEGH-CEL researcher and medical director of Mendelics a private genomic analysis laboratory that took part in the sequencing of the three diseases “The lithium that is administered to patients with bipolar disorder inhibits the action of the gene.”  However before the Brazilian researchers’ study was published on October 2 no mental problem had been linked to Impa1 The studies of rare genetic diseases both old and new in Brazil’s Northeast are far from over the challenge now is to understand the physiological mechanism caused by the mutation in those affected by the syndrome which progressively forces them to life in a wheelchair The high prevalence of disturbances and syndromes caused by marriages between relatives is one indication that there is still much to be studied A national survey published in 2014 points to the fact that there are nearly 4,000 people from more than 80 towns who present low-incidence genetic diseases in communities that are relatively isolated from the rest of the country “Several countries pay a lot of attention to highly inbred populations or those with low genetic diversity the Arab-Israelis in Israel and the Finnish,” notes Kok “We still know very little about the genetic diseases in Brazil.”  Advances in genetic studies driven by new technologies and by a better ability to analyze vast amounts of data are leading to a better understanding of the roots of rare diseases like SPOAN as well as much more common conditions such as muscular dystrophy Mutations in two new genes cause Noonan’s syndrome  Study expands the molecular basis of the disease and raises to 11 the number of genes involved in the clinical condition  Researchers at the CEGH-CEL discovered two new genes associated with Noonan’s syndrome a disease nearly as prevalent as Down’s syndrome According to an article published in the Journal of Medical Genetics in June 2015 mutations in the S0S2 and LZTR1 genes are responsible for 3% of all cases of the disease The first gene is on chromosome 2 and the second on chromosome 22 According to some estimates, the syndrome that can affect different areas of the body (see drawing) strikes one out of every 2,500 newborns Other estimates place the number at one out of every 1,000 newborns “The most important anomalies that lead parents to seek medical care are cardiac issues and short stature,” says CEGH-CEL geneticist Débora Bertola a physician at the Children’s Institute of the Hospital das Clínicas (HC) at USP “The clinical characteristics of the syndrome vary greatly There are probably many affected individuals who do not even know they have it.”  The disease does not generally affect an individual’s life expectancy Noonan’s syndrome is classified as a monogenic autosomal dominant disorder One need only inherit a single copy of one gene with the pathogenic mutation to develop the disease mutations in nine genes were associated with 80% of all cases of the disease those affected have some harmful mutation in just one of the genes that can cause the syndrome the number of genes associated with the syndrome increased to 11 “The trouble today is finding genes that are responsible for a very small percentage of cases of the disease,” Bertola explains “The discovery of the mutations in these two genes improves the effectiveness of the molecular diagnosis of the syndrome,” says Maria Rita Passos-Bueno coordinator of the Technology Transfer Department of the CEGH-CEL all the other genes responsible for  development of the syndrome are associated with the RAS/MAPK signaling pathway whose deregulation seems to be crucial in the emergence of the disease In order to discover what links the two genes to the syndrome scientists sequenced the coding portion of the genome of 50 patents from the HC who had the disease but presented no mutations on the nine genes known to be associated with the disease up to that time Projects 1. CEGH-CEL – Human Genome and Stem-Cell Research Center (nº 2013/08028-1); Grant Mechanism Research Innovation and Dissemination Centers (RIDC); Principal Investigator Mayana Zatz (IB-USP); Investment R$9,609,746.03 and US$4,676,005.00 for the entire project Program of the Center for Genetic Studies and Education at the State University of Paraíba (NEGE-UEPB); Principal Investigator Silvana Santos (UEPB); Investment R$ 200.000,00 (PROPESQ/UEPB © Revista Pesquisa FAPESP - All rights reserved Journal of Arid EnvironmentsCitation Excerpt :Although some classification criteria have been highlighted (phytophysiognomy and relief) it was not possible to establish a hierarchy between them and the other criteria the Caatingueiros employed to identify landscape units topographic and physiognomic factors stand out but without a clear hierarchy between them 2019) and the Cerrado/Caatinga ecotone (Matuk et al. only the edaphic factors seem to be a priority to define general categories of landscapes in a folk classification of the white-sand Campinarana in the Amazon (Abraão et al. New Jerusalem Theater seems more like a medieval castle than a performance space this massive open-air theater puts its gigantic space to use for a roving portrayal of the Passion of Christ 2.2 miles of walls and 70 towers flank the outer perimeter of the New Jerusalem Theater making it by far the largest open-air theater in the entire world The first passion play in the town took place in 1951 and was comprised only of a few family and friends playing all of the roles when the townspeople began constructing a replica Jerusalem in a dusty region of Brejo da Madre de Deus the play has grown to include 550 actors and 9 sets including The Upper Room an average of 8,000 people per show from around the globe follow the actors as they move through "ancient Jerusalem," portraying every step of the Passion of Christ an inn within the walls of the New Jerusalem Theater allows visitors to stay just feet Jesus and the other performers Two churches shoot bottle rockets at each others' bell towers in an unusual Easter celebration Annual convention held by the largest pyrotechnic community in the world Bold contestants slide in a rice paddy behind two charging bulls Machismo turned on its head: the lady's hand goes to the dude with the bigger brain Men in rubber-soled boots serve as your "brakes" on this toboggan ride Hemingway described as "exhilarating." A park in Mexico offers all the experiences of an illegal border crossing except for one: the border that has been played since prehistoric times The handmade leather armor not only protects from the burning sun but also shields from the scratchy bare branches and long spiky needles of the surrounding bush the James Gang – these good and bad hombres of the frontier: They walk tall ride hard and spend more time with guns than cows A new book by Uruguayan photographer Luis Fabini gives a truer picture Fabini has photographed real cowboys in eight countries on the two continents of the Americas I stayed on holidays with my family on a ranch in northern Uruguay,” he says It was like the world suddenly exploded in my head the world’s largest wetlands and one of the most pristine and bio diverse environments on the planet locally known as Terras d’ Agua or Waterlands Those childhood memories led Fabini on a 10-year journey through Chile and an exhibition on view until April 2 at the Whyte Museum of the Canadian Rockies in Banff as part of Alberta's annual Exposure Photography Festival His family moved frequently – from Uruguay to Belgium Brazil and the United States – and the camera became Fabini’s way of adapting he began working as a trekking guide in Peru eventually becoming a fashion and commercial photographer he had become disenchanted with the industry and with himself “I stopped everything.” He studied with a Zen master for three years sometimes sitting for six hours in meditation “I knew that I wanted to do something more as a photographer I had no money but I knew I was going to do it no matter what first met Fabini in Banff when he was on his way through Alberta to shoot Canadian cowboys the hardest thing was to select 16 or 17 images from his 107 in the book,” says Richards and South America.” The images are shot digitally and those selected range through captivating portraits such as a vaqueiro wrestling down a bull by hand Pedro Arthur shows off his skills as farmer and cattle breeder the biggest challenge is how much he is willing to sacrifice for the cowboys’ way of life Amplifying the compelling images in the book is an equally eloquent text by Canadian anthropologist and explorer Wade Davis His words broaden the visual information with an edifying contemplation of history of the cowboys in Chile – the huasos – he writes: “Known also as arrieros cordilleranos they are a mix of native and mestizo blood as relentless as the glaciers that slowly carve away the flanks of the Andean Cordillera.” Such words and Fabini’s images show us not the myth soul brothers despite the distances between them Where does Fabini’s work fit into photographic art of today Richards says: “I think this is documentary work He has documented these different cultures within the Americas “I don’t have a goal of documenting something,” he says “Every time someone asks me what kind of photography I do I work from my heart and that’s why I say I’m a visual poet-photographer What fascinates me is the connection between man and earth I’m trying to connect with my surroundings through colour The Exposure festival takes place at 40 galleries in Banff with each gallery curating its own exhibitions The Whyte is showing two other photographic exhibitions – the tableaus of Winnipeg artist Diana Thorneycroft a museum outreach project with students at Bow Valley High School Fabini speaks less about the technical aspects of photography and more about his passion and discoveries but they have pride and dignity and they work very hard in harsh conditions I followed that thread all around the Americas and I have found a net of solidarity and it makes me believe more in humanity.” WebsiteVisit Website arts journalist and former Banff Poet Laureate has contributed to many art and literary magazines Notable works are his seven-book poetic series fluttertongue and his recent book Glimmer: Short Fictions especially notable is one photo of McIntyre Ranch in Southern Alberta Worth to visit the Whyte for Through the Lens and Diana Thorneycroft too.Craig Richards did a fabulous swan song show for the Whyte You are supporting the arts and making a lasting impact by donating to Galleries West Whether you choose a monthly contribution or a one-time gift your support helps us spotlight emerging talent and sustain the vibrant creative community across Western Canada we can ensure that our open-access site continues to thrive and inspire for generations to come Error 404: Page Not FoundWe're sorry, the page you’re looking for doesn't existWatch these videos instead IPL V PSL: Ricky Ponting Blames PSL for Punjab's Woes | First Sports With Rupha Ramani | N18G India's Crackdown On Pak Continues, Bans Nadeem's Instagram | First Sports With Rupha Ramani | N18G United Accused Of Re-Selling Tickets For Shocking Rates | First Sports With Rupha Ramani | N18G Terrorism Surges in Nigeria; Boko Haram, ISWAP Regain Strength | Firstpost Africa | N18G Somalia Bans Entry of Taiwanese Citizens To Please China: Taipei | Firstpost Africa | N18G Kenya Faces Alarming Need For Antivenom Amid Surge In Snake Bite Cases | Firstpost Africa | N18G Kenya Battles Snakebite Rampage | Firstpost Africa | N18G Trump Claims India & Pakistan Fought Over Kashmir for 1,500 Years | Vantage with Palki Sharma | N18G Nossos serviços estão apresentando instabilidade no momento Algumas informações podem não estar disponíveis 2018 02h00 PM | Last Updated: December 10 Cabeço Island is located right in the mouth of the São Francisco River and it is part of the municipality of Brejo Grande (SE) the river divides the states of Alagoas and Sergipe and drains off in the Atlantic the community of Cabeço mainly lived from fishing as well as from the cropping of rice and coconut Since the construction of the barrage of the Xingó Hydroelectric Power Plant in that decade the lighthouse of São Francisco do Norte reminds the history of the village that disappeared in the mouth of the Old Chico the lighthouse that guided ships for more than 120 years stood on solid ground and continues jokingly: "even dead people drowned!" 55-year-old fisherman Manuel dos Santos lives in Piaçabuçu today a municipality on the Alagoas side of the mouth of the São Francisco River The lighthouse is still in the middle of the sea Santos left Cabeço when he was 17 years old: "When things begin not to work anymore we begin to look for other ways...and so on as the São Francisco River is drying...this has mistreated people that live from fishing" Many species of fish are vanishing from the river: "pilombeta xirá...there are no more freshwater fishes that stood in the creeks in Brejo Grande The cropping of rice and coconut in the region was also affected by the salinization of the water and decreasing flow of the São Francisco River which killed the coconut trees and affected the flooding areas where rice was cropped Both Santos and Chico attribute the advance of the sea to the construction of the barrages upstream: "São Francisco River is suffering due to the barrages "We do not have more river water due to these barrages the construction of barrages causes significant changes in the natural dynamics of rivers the river carries silts from the continent and lays them in the mouth most of the silts do not arrive at this point The control of floods and flows of the hydroelectric plants also affects the laying of silt as it changes the natural seasonality of the rivers Stenner also explains that the structural process of occupation of the São Francisco basin has been causing a degradation and loss of natural vegetation in many areas: "this leads to a reduction in the reload capacity of all the system: without vegetation which also causes more silting in the river" Another factor is the dispute for the use of water: the volume of the river water is limited and the water of the Old Chico is key to supplying "Such management always involve a conflict because any increase in the production of electricity causes a reduction in the water for irrigation On top of all this there is the issue of global warming intensifying the natural cycles of drought and reducing the volume of water of the São Francisco River the Old Chico arrives weakened at its mouth and keeps on losing space for the salty waters of the Atlantic See more on the São Francisco onRetratos #13 and on the following links: Riverside jobs still resist in the São Francisco São Francisco River enables strategic connection between Major Regions in Brazil Video reports presents Old Chico, the enduring river © 2018 IBGE - Instituto Brasileiro de Geografia e Estatística Nós utilizamos cookies para melhorar sua experiência de navegação no portal. Para saber mais sobre como tratamos os dados pessoais, consulte nossa Política de Privacidade. Canadian Russell Bowie has ignited hopes of emulating hero Adam Scott with a victory at RACV Royal Pines Resort after producing the round of the tournament at the World Deaf Golf Championships on the Gold Coast Bowie shot 5-under 67 in Round 2 on Tuesday an improvement of 12 shots on his opening round that he attributed to struggles with the putter on the grainy greens that Queensland is famous for He pushed those difficulties aside on day two playing his back nine in 5-under 31 to now trail 2022 champion Nico Guldan (74) of Germany by just one shot at the halfway mark Australian Jack Besley (75) is tied for third two strokes back of Bowie the Southern Golf Club Assistant Course Superintendent eight strokes clear of Englishman Aiden Kelly (74) and American Pono Tokioka (82) who share fourth spot Bowie is now within reach of joining the 2019 Australian PGA champion as a tournament winner at Royal Pines a plus-3 handicap at Brampton Golf Club in Ontario “Just like the way he handles and carries himself kind of someone you want to emulate in every way “I just saw on a board there that he has won at this golf course so that’s pretty cool.” Runner-up to Guldan at the 2022 Championship in Hawaii Bowie attributed his turnaround to a much-improved day on the Royal Pines greens Turning in even par after starting from the 10th tee Bowie holed 30-footers for birdie at both two and three converted chances from inside five feet at four and seven and then made a 20-foot putt for birdie on eight to set the benchmark for low score of the week “I made a couple of nice long putts and the difference was yesterday I would’ve maybe three-putted those,” Bowie added one putt and there’s four strokes right there between two holes “The score yesterday went in the wrong direction It was the opposite scenario for Round 1 leader Guldan who was unable to convert three early birdie chances on what would prove to be a frustrating day on the greens His lone-birdie in a round of 2-over 74 came at the par-5 15th the German’s position on the leaderboard his lone positive heading into Round 3 “That is the only good thing,” said Guldan of remaining on top of the leaderboard through 36 holes “I started with three one-metre putts for birdie and didn’t make one It shapes as a race in two in the women’s event with Round 1 leader Margaux Brejo and defending champion Vanessa Girke now eight strokes clear of third-placed Erica Pressley from America Brejo battled with her short game in a round of 2-over 74 to be 1-over through two rounds as Girke’s recent back issues flared up late in her round of 1-over 73 The 17-year-old from France will start Round 3 with a two-stroke lead and excited by the chance to once again play alongside her German counterpart who she edged in last year’s European Deaf Championship in Finland “This is very different to play with the leaders “Vanessa is an incredible player and this is an exchange Girke was 3-under on her round when her back issues led to four straight bogeys from the 13th hole She battled through to make two gutsy pars to finish and stay within reach of Brejo with two rounds to play “The last few holes I was in so much pain,” said Girke And the last one I had to play my third shot to the green Debbie Byrnes is the best of the Aussies in the women’s event with Chantell Greaves one shot further back in a tie for 11th Round 3 tees off at 7am on Wednesday morning with the lead groups to begin their third rounds at approximately 9am Live scores available here indigenous people preserve ancestral rituals and traditions It is possible to be indigenous in the city of São Paulo the Pankararu ethnic community experiences urban space as an extension from the Brejo dos Padres indigenous land The daily lives of families respect ancestral customs Migration to the capital of São Paulo began in the 1940s Today they no longer settle in urban spaces for better living conditions is also a search for knowledge production and a way of experiencing the world” explains the researcher Arianne Rayis Lovo Anthropologist trained at the Institute of Philosophy and Human Sciences (IFCH) defended at the Institute of Philosophy and Sciences Humanities (IFCH) at Unicamp The work was guided by José Maurício Arruti and co-supervised by Artionka Capiberibe the indigenous people moved to the capital of São Paulo to work in construction The ethnicity It suffered processes of missionary villages in the 16th and 17th centuries and consequently forced miscegenation Despite not having the characteristics commonly attributed to indigenous people “so widespread in the national imagination in the figure of the generic Indian” the pankararu still maintain their practices and rituals both in the village and in the city and the healing practices carried out by the prayer women They promote the work of “closing” the body and homes mediating between the physical and spiritual worlds Arianne studied how the group's domestic spaces are configured whether there are formal transformations in its social organization The traffic between village and city was studied by observing the daily life of a family that Arianne accompanied during the research “The spaces of the village and the city are coextensive the indigenous people go to the village whenever necessary to visit relatives or participate in rituals those who live in indigenous land come to São Paulo to seek education There are even those who discovered themselves as indigenous people in the city in a process of self-affirmation of identity” the pankararu have networks of relationships there is a political and administrative organization favored by the “SOS Pankararu” association The association facilitates access to higher education Many indigenous people benefit from the “Pindorama” program a partnership between PUC-SP and the Pastoral Indigenista of the Archdiocese of São Paulo and indigenous communities which offers reservation of places and scholarships for different ethnicities in university courses carried out in the village and also in São Paulo are private and carried out throughout the year or on an extraordinary basis “This is a very important custom for the constitution of the notion of person because the Pankararu believe that the body is open and must be closed at all times” The work of the prayer workers is sometimes concomitant with that of medicine Arianne accompanied a medical team that provided care to the indigenous people at the local health unit The fieldwork continued with the beginning of the observations made by the researcher who in 2015 was in the Brejo dos Padres village at the family home that also received her in São Paulo the anthropologist witnessed the “Corrida do Embu” and “Penitência” two rituals that take place during the same period The pankararu perform rites of celebration for the dead honoring both those who have recently died (so that their “crossing” is peaceful) and the important leaders of the group they stop on the paths of the village where the crosses of the dead are and pray They also walk to the home of religious leaders such as the blessed Madrinha Dodô and the messianic Padrinho Pedro Batista people who had a strong influence among the pankararu” Arianne assesses that although the issue of demarcating indigenous lands is crucial for indigenous people the idea of ​​territory goes beyond what has been legally demarcated “The way they appropriate the space is also important because it is where they are.” Listen to the podcast about the research here: Access JU news on Unicamp’s social networks secexec@unicamp.br