The Chronicle is highlighting pivotal figures and events throughout the University’s history
Duke’s West Campus is best known for its dramatic Gothic architecture and the grand chapel that sits at the heart of its central quad
wasn’t fully recognized for his contribution to the University’s design until decades after his death
Abele — who may have never stepped foot on the campus he designed in the then-segregated South — was finally memorialized by the University in 2016 with the renaming of West Campus’ main quad to “Abele Quad.”
The Chronicle looks back on the story of the man responsible for crafting the now-iconic campus
Abele was born April 21
Julian himself followed his siblings in attending the Institute for Colored Youth, founded in 1873 as the first public preparatory school for Black children. Abele was mentored by the principal of his school, Fanny Copin
who encouraged him to pursue architecture and a higher education
Although educational opportunities were limited for Black people at the time, in 1897, Abele became the first Black person to receive a Certificate of Architectural Drawing at the Pennsylvania Museum and School of Industrial Art
He enrolled in the University of Pennsylvania’s School of Architecture the next year and was elected president of the student architectural society in his senior year
he became only the third Black person in the country to earn a bachelor’s degree in architecture and the first Black graduate at UPenn
though the segregationist policies of the time prevented him from participating in his commencement ceremony
“Those behind in the race of life must run faster or forever remain behind,” Abele once said in regards to his educational pursuits. At the time, he was the “most formally educated architect” in the country
It was at UPenn’s two-year program where Abele’s admiration of French architectural styles manifested, as the school was one of the first in the nation to incorporate teachings from the renowned École des Beaux-Arts in Paris. His later work on the Free Library and Museum of Art in Philadelphia are reflections of his admiration for Ange-Jacques Gabriel
After graduating, Abele acquired a Certificate of Completion in Architectural Design from the Pennsylvania Academy of Fine Arts in 1903
He went on to be hired by Horace Trumbauer in 1906
where he gained much of his architectural experience
since company policy dictated designs would be signed in the name of the firm
“The lines are all Mr. Trumbauer’s, but the shadows are all mine,” Abele said
— later characterized the relationship between his father and Trumbauer as one marked by “a great deal of respect.”
Abele took over the firm alongside fellow architect William Frank after Trumbauer’s death in 1938
finally able to sign his own name on his designs
He remained at the firm until his death in 1950
Abele’s relationship with Duke began after Trumbauer’s firm was commissioned to design tobacco magnate James B
The company later drafted an expansion to Duke’s property in Newport
and drew up plans for a New Jersey estate that was never developed
Abele designed many of West Campus’ most iconic facilities
He was also responsible for redesigning East Campus
in a Georgian architectural style and for drafting the plans for Baldwin Auditorium
Abele designed a total of 11 Georgian-style buildings on East Campus and 38 Gothic-style buildings on West Campus
Due to segregation policies in the Jim Crow South, Abele may never have visited the final manifestations of his designs at Duke — the matter remains unclear because many of the architectural firm’s records were destroyed after the business closed in 1968
After much of the construction was complete, the firm consulted a professor at Vanderbilt University for input on the statues to be placed at the Chapel entrance
He recommended the company choose “three men of prominence in the South” — former President Thomas Jefferson
None of the men had any connection to the University
and no credit was given at the time to the Black architect who designed the campus
“He was a victim of apartheid in this country,” Cook wrote in her letter
one of many student mobilizations that contributed to the Duke Board of Trustees ultimately voting in May 1986 to divest from companies profiting from business in segregated South Africa
In 2016, a Duke Bass Connections team investigated how the University’s history is told to prospective students and families touring the school. They found that tour guides rarely mentioned Abele and his contribution to Duke — even after Abele Quad was named after him earlier that year
The team concluded by calling on Duke leadership to “acknowledge and examine those times when unjust decisions were made.”
staff and faculty must be able to see themselves in both the line and shadow of Julian F
Abele’s Quadrangle,” the team wrote in the report
The University now honors Abele with a portrait of the architect that originally hung in the foyer of the Allen Building — the first of a Black person to occupy the space
It now hangs in the Gothic Reading Room of the David M
Rubenstein Rare Book and Manuscript Library
Aseel Ibrahim is a Trinity sophomore and an associate news editor for the news department.
Zoe Kolenovsky is a Trinity junior and data editor of The Chronicle's 121st volume. She was previously news editor for Volume 120.
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Volume 15 - 2025 | https://doi.org/10.3389/fcimb.2025.1543100
Introduction: The rising use of dental implants is accompanied by an expected increase in peri-implant diseases
which poses a significant threat to implant success and necessitates a thorough understanding of its pathogenesis for effective management
Methods: To gain deeper insights into the role and impact of the peri-implant microbiome in the pathogenesis and progression of PI
we analyzed 100 samples of saliva and subgingival biofilm from 40 participants with healthy implants (HI group) or with co-occurrence of diagnosed PI-affected implants and healthy implants (PI group) using shotgun metagenomic sequencing
We identified the most discriminative species distinguishing healthy from diseased study groups through log ratios and differential ranking analyses
Results and discussion: Mogibacterium timidum
Porphyromonas gingivalis and Olsenella uli were associated with the subgingival peri-implant biofilm
Rothia mucilaginosa and Rothia aeria were more prevalent in the healthy peri-implant biofilm
Functional pathways such as arginine and polyamine biosynthesis
including putrescine and citrulline biosynthesis
showed stronger correlations with PI-affected implants
peri-implant health was characterized by the predominance of pathways involved in purine and pyrimidine deoxyribonucleotide de novo biosynthesis
glucose and glucose-1-phosphate degradation
Our findings reveal that healthy implants in PI-free oral cavities differ significantly in microbial composition and functional pathways compared to healthy implants co-occurring with PI-affected implants
which more closely resemble PI-associated profiles
where microbial and functional biomarkers follow similar trends
Bacteria play a central role in biofilm formation
acting as primary colonizers and dominating both in abundance and function within a healthy oral microbiome
the oral microbiome is a complex ecosystem encompassing fungi
all of which must be considered to comprehensively understand the microbial community
Future advancements in this field are likely to hinge on integrative analyses that encompass the complete metagenome and metatranscriptome of the entire microbial consortium
Shotgun metagenomic sequencing has more power to identify less abundant taxa and more capacity to identify most microorganisms at the species level than 16S rRNA sequencing, and it allows to obtain the potential functional profiles of the microbial communities analyzed (Durazzi et al., 2021)
we utilized shotgun metagenomic sequencing to analyze the microbiomes of saliva and subgingival peri-implant biofilms
aiming at identifying distinct microbial signatures and potential functional pathways associated with PI
The study design included patients with healthy implants as well as those with co-occurring PI-affected and healthy implants
Saliva samples were analyzed to evaluate their potential as a non-invasive diagnostic tool for identifying PI biomarkers
This cross-sectional study is reported based on the 2020 revised PRISMA statement (Page et al., 2021)
It was carried out according to the Helsinki Declaration (as per the 2013 revision)
and all participants signed a written informed consent form before participation
The study was approved by the Egas Moniz Ethics Committee (process number 1123)
Participants seeking dental care at the Egas Moniz Dental Clinic (Almada
Portugal) were invited to participate if: aged 18 years old or over; presence of at least one dental implant with a history of at least one year in function; no diagnosis of periodontitis; no history of local or systemic antibiotics or oral antiseptic mouth rinses use within the past 2 months
Women being pregnant or breastfeeding were not included in the study
The sampling period was from January 2023 to September 2023
Every clinical procedure strictly adhered to the principles outlined in the Declaration of Helsinki and the guidelines of Good Clinical Practice
A brief questionnaire was used to gather relevant demographic and clinical information
presence of immune or inflammatory diseases
number of remaining teeth and dental implants
All information underwent de-identification before creating the database and conducting data analysis
The participants were asked to refrain from oral hygiene for 24 hours and from eating and drinking for 2 hours before the examination and sampling
To define peri-implant health or PI, the criteria included in the 2018 Classification of Periodontal and Peri-implant Diseases and Conditions (Caton et al., 2018) were used
The diagnosis of a healthy implant involved the following clinical criteria: absence of clinical signs of redness and swelling
absence of bleeding upon probing (except in one location
absence of increased probing depth (when compared to previous examinations)
After clinical inspection and a final diagnosis
participants were assigned to one of two groups: patients with healthy implants (HI group) or patients with co-occurrence of diagnosed PI-affected implants and healthy implants (PI group)
we collected a saliva sample and one or two subgingival peri-implant biofilm samples
In group HI we obtained a saliva sample (HI_Sa) and a subgingival biofilm sample from a healthy implant site (HI_HIS)
a subgingival biofilm sample from a healthy implant site (PI_HIS)
and a subgingival biofilm sample from an implant site affected by PI (PI_PIS)
Sampling was performed prior to any antiseptic mouthwash use
Two milliliters of unstimulated saliva were collected from each participant by drooling into a 4-mL cryotube with the aid of a saliva collection aid device (Salimetrics, USA). All samples were immediately transported to the laboratory, where glycerol was added to a final concentration of 20% in aseptic conditions, and then stored at -80°C in aliquots of 1 mL (Marotz et al., 2021)
and then stored at -80°C for subsequent DNA extraction
The extraction of total genomic DNA from frozen saliva and subgingival biofilm samples was performed using the DNeasy PowerSoil Pro kit (Qiagen, Germany). However, a prior step was performed to selectively deplete human DNA, as Marotz et al. (2021) described
with minor modifications and detailed next
Control extractions were performed using only sample buffer to determine potential contamination during the protocol execution and using the ZymoBIOMICS Microbial Community Standard (Zymo Research Corporation
USA) to validate the efficacy of the extraction method
comprising 40 from saliva and 60 from subgingival biofilm
One-mL saliva aliquot was thawed, vortexed, and then centrifuged at 15,000 ×g, room temperature, for 6 min to pellet cells. Before DNA extraction, a method was applied to selectively deplete host DNA, based on that described by Marotz et al. (2021)
the pellet resuspended in 200 μL nuclease-free H2O and left at room temperature for 5 min to allow for osmotic lysis of human cells
Propidium monoazide was added to a final concentration of 10 μM
at approximately 12 cm from a blue light (wavelength of 480 nm) and exposed for 25 min
Samples were then centrifuged at 15,000 × g
and the pellet resuspended in 800 µL of solution CD1 (from the DNeasy PowerSoil Pro kit)
immediately transferred to a PowerBead Pro tube of the same kit
briefly vortexed and incubated at 65°C from 10 min and processed according to the manufacturer’s protocol from step 2 on
centrifuged at 15,000 ×g for 6 min at 4°C
washed once with 750 µL of PBS 1×
resuspended in 200 μL nuclease-free H2O
briefly vortexed and left at room temperature for 5 min
the PMA protocol was the same as described above
the PP strips were prior transferred to a PowerBead Pro tube
and the pellet resuspended in 800 µL of solution CD1 was also transferred to the same tube
followed by vortexing and incubation at 65°C from 10 min and then the manufacturer’s protocol from step 2 on
The project consisted of the sequencing of 100 DNA metagenome samples
The concentration of DNA was determined with the Qubit 2.0 Fluorometer (Life Technologies) using the Qubit dsDNA HS Assay Kit (Life Technologies)
Each DNA library was prepared from 0.5 nanograms of high-quality genomic DNA with the Nextera XT DNA Sample Preparation Kit (Illumina
USA) and paired-end sequenced in the NextSeq 2000 Illumina® sequencer with the NextSeq 1000/2000 P2 XLEAP-SBS Reagent Kit (300 cycles
All procedures were performed according to standard manufacturer’s protocols
Sequenced reads were quality-filtered with Trimmomatic version 0.39 (Bolger et al., 2014) using the following parameters: 1) sequencing adapters were removed, 2) bases with an average quality lower than Q25 in a window of 5 bases were trimmed, and 3) reads with less than 100 bases were discarded. High-quality reads were filtered against the reference human genome sequence assembly GRCh38/hg38 with Bowtie version 2.5 (Langmead et al., 2009)
The demographic and clinical data of patients were analyzed using IBM® SPSS® Statistics v.29
applying comparative statistical tests such as Pearson’s chi-square test or Mann-Whitney
based on variable types and data characteristics
Values of p < 0.05 were considered significant
High-quality sequences were analyzed with MetaPhlAn version 4.0.6 (Blanco-Míguez et al., 2023) for determining taxa abundances using the MetaPhlAn clade-specific marker genes mpa_vOct22_CHOCOPhlAnSGB_202212 database
The number of read counts for each taxon identified at the species level per sample was retrieved and used to build an abundance table comprising read counts from all samples
The abundance table was used for composition
alpha and beta diversities and differential abundance analyses
The number of reads mapping to fungi and viruses on the MetaPhlAn database was very low or even absent. To overcome this limitation, the high-quality reads were analyzed with Kraken2 version 2.1.1 (Wood et al., 2019) against the Viral genomes (2019) and the Fungi genomes (2019) Kraken databases. Abundance estimation at the species level was retrieved with Bracken version 2.9 (Bayesian Reestimation of Abundance with Kraken) (Lu et al., 2017)
The number of read counts for each taxon identified per sample was used to build an abundance table comprising information from all samples
Hill numbers were calculated for Species richness, Shannon and Inverted Simpson with the hilldiv package, version 1.5.1 (Alberdi and Gilbert, 2019)
Hill numbers were compared using analysis of variance (ANOVA) followed by Tukey’s test or the Kruskal-Wallis test
followed by Dunn’s test with Bonferroni correction
after testing for normality with the Shapiro test
Beta diversity was analyzed with Principal Coordinates Analysis (PCoA) in phyloseq using the Bray-Curtis dissimilarity and the Jaccard similarity coefficient. The indexes were tested for statistical differences with PERMANOVA, followed by pairwise PERMANOVA using the adonis function of the vegan package version 2.6-4 (Oksanen et al., 2020) with 1000 permutations and the Benjamini-Hochberg procedure for multiple comparison corrections
Homoscedasticity was tested with the betadisper function of the vegan package
The 10% most influential species were analyzed according to PCA axis 1 or 2
The abundance table was additionally analyzed with Songbird version 1.0.4 (Morton et al., 2019) to identify correlations between taxa and study groups
Songbird was run in Qiime2 version 2020.2 in the multinomial mode with the parameters 50,000 epochs
a minimum sample count of 50 and a minimum feature count of 20% of the samples
Log ratios of relevant bacteria were extracted from Qurro
Data visualization and statistical inference analyses were performed using IBM SPSS Statistics v.30
A p-value and an adjusted p-value of < 0.05 were considered statistically significant
High-quality sequences were analyzed with HUMAnN version 3.9 (Beghini et al., 2021) to determine the abundance of the functional pathways present in the metagenomes using the MetaPhlAn clade-specific marker genes mpa_vOct22_CHOCOPhlAnSGB_202212 database
The unstratified functional pathway data was used to build an abundance table comprising read counts from all samples
The abundance table was used for composition and beta diversities analyses (Bray-Curtis dissimilarity
and Robust Aitchison distance and PCA using DEICODE) and was additionally analyzed with Songbird version 1.0.4 to identify correlations between functional pathways and study groups
All these analyses were performed as described above
Demographic and clinical characteristics of the sampled population (patients in HI and PI groups)
From the 100 sequenced samples, a total of 652,464,113 high-quality read pairs were obtained, from which 439,265,781 were non-human read pairs, with an average of 4,392,658 read pairs per sample (ranging from 299,855 to 27,677,702). Sequencing and analysis metrics are shown in Supplementary Table S1
Sequence analysis using MetaPhlAn software identified 596 bacterial species present in at least one sample
52 fungal species and 586 viral species (though most viral species were not shared among samples and were present in very low relative abundances) were identified using Kraken2
The vast majority of viruses were bacteriophages
Fifty-eight bacterial species were pinpointed with a relative abundance of > 1% in at least one of the five study groups, as shown in Figure 1A
The sum of their average relative abundances was 78.95%
the PI_PIS group exhibited a greater percentage of species that were present in very low relative abundances compared to the other study groups
(A) Relative abundances (>1%) of the bacterial composition at the species level in each study group
(B) Hill diversity indices (Species richness
Shannon and Inverted Simpson) of the bacterial communities of the five study groups
Supplementary Figures S2A, B of Supplementary Material show the relative abundance (>1%) of all species of fungi and viruses
Schizosaccharomyces pombe was the most abundant fungus in all study groups
Most abundant phages were associated with Streptococcus spp
Hill diversity, which includes species richness and modified versions of the traditional Shannon and Simpson indices, was used to measure the diversity of the bacterial community of each study group (Figure 1B)
Bacterial Hill-species richness did not differ significantly between the two study groups of saliva nor among the three study groups of subgingival biofilm from implant sites
saliva groups had higher species richness (large number of rare species) than subgingival biofilm groups
which emphasizes the dominance of common species in a community
The Hill-Shannon index balances the influence of species richness and evenness in a community
The Hill-Shannon diversity of the saliva groups (HI_Sa and PI_Sa) was substantially higher than the groups of subgingival biofilms of healthy implants (HI_HIS or PI_HIS)
the PI_PIS was not statistically different from any other of the four study groups
the groups showing higher diversity in terms of presenting a higher number of rare species and a higher number of common species were both saliva groups
they were all homogeneous regarding species richness
PI-affected implants tendentially showed bacterial communities with higher Hill-Shannon diversity than healthy implants
although those differences were not statistically significant
Hill diversity indices were also calculated for fungal and viral communities of each study group (Supplementary Figures S2C, D of Supplementary Material)
no statistically significant differences were observed between the two study groups of saliva nor among the three study groups of subgingival biofilm from implant sites
major and significant differences were pinpointed between saliva and subgingival biofilms groups
regardless of the presence of health or disease (PI)
Significant taxonomic differences in the oral metagenome of saliva from healthy and PI-affected patients (HI_Sa vs PI_Sa)
(A) Bacterial differential ranks of the 23 out of 231 (9.96%) species more (identified as numerator) and less (identified as denominator) associated with PI_Sa using the group HI_Sa as reference
as estimated from multinomial regression by Songbird
(B) Log ratio plots of the 23 out of 231 species across HI_Sa and PI_Sa groups
(C) Log ratio plots of specific combinations of bacterial species across HI_Sa and PI_Sa groups
Statistical significance based on a Student’s t-test (*p < 0.05; **p < 0.01)
Similarly, log ratios were calculated for the subgingival biofilm groups. Figure 3 displays the differential rankings of the top and bottom 10% of species that changed the most relative to each other between the two groups being compared (see also Supplementary Tables S4-S6)
Key species were highlighted based on their ranking and/or enrichment (positive and higher intercept)
Differential ranks of the 10% species changing the most relative to each other in the two compared groups of subgingival biofilms
(A) 14 out of 145 species presenting very different ranks in PI_HIS vs PI_PIS
(B) 15 out of 159 species presenting very different ranks in HI_HIS vs PI_PIS
(C) 13 out of 137 species presenting very different ranks in HI_HIS vs PI_HIS
and several species of Actimomyces were more associated with HI_HIS
The log ratio of all species selected at the 10% threshold was significantly higher in PI_PIS compared to HI_HIS and in PI_HIS compared to HI_HIS (p < 0.01). Although an increase was also observed in PI_PIS compared to PI_HIS, this difference did not reach statistical significance (p = 0.054), as shown in Figure 4
Log ratios of the top and bottom 10% species changing the most across the two groups in comparison
Statistical significance based on a Student’s t-test (**p < 0.01)
which reinforces the differences in the microbiome of healthy implants depending on whether there is co-presence of PI-affected implants in the same oral cavity or not
Log ratio plots of specific combinations of bacterial species across HI_HIS and PI_PIS groups (A)
Differential ranks for the top 10% most and least influential fungal species associated with the disease group, using the healthy group as a reference, were also obtained (see Supplementary Table S7)
were used to calculate log ratios; however
no statistically significant differences were observed in the log ratios between the two groups compared
Candida albicans was consistently identified as the numerator associated with disease groups PI_Sa (compared to HI_Sa) and PI_PIS (compared to either PI_HIS or HI_HIS)
and we could identify which species were changing the most relative to each other
those species were mostly bacteriophages and the log ratios calculated were not statistically different across compared groups (data not shown)
30 of 302 were selected for the HI_Sa and PI_Sa groups
Several functional pathways were consistently more associated with the PI condition
including the biosynthesis of arginine and polyamine
as well as the degradation of purine nucleobases
Other pathways could be pinpointed as health-promoting
including the de novo biosynthesis of purine and pyrimidine deoxyribonucleotides
and biosynthesis of sulphur amino acids (cysteine and L-methionine)
Log ratio plots of the top and bottom 10% functional pathways selected across HI_Sa and PI_Sa (A)
and log ratio plots of specific combinations of functional pathways across HI_Sa and PI_Sa (B)
Statistical significance based on a Student’s t-test (*p < 0.05)
Log ratio plots of the top and bottom 10% functional pathways selected across PI_HIS and PI_PIS (A)
and log ratio plots of specific combinations of functional pathways across PI_HIS and PI_PIS (B)
Log ratio plots of the top and bottom 10% functional pathways selected across HI_HIS and PI_PIS (A)
and log ratio plots of specific combinations of functional pathways across HI_HIS and PI_PIS (B)
Log ratio plots of the top and bottom 10% functional pathways selected across HI_HIS and PI_HIS (A)
Log ratio plots of a specific combination of functional pathways across HI_HIS and PI_HIS (B): log [PWY-5838: superpathway of menaquinol-8 biosynthesis I + PWY0-1297: superpathway of purine deoxyribonucleosides degradation + P124-PWY: Bifidobacterium shunt/PWY-5918: superpathway of heme b biosynthesis from glutamate + PWY-8131: 5’-deoxyadenosine degradation II + PWY-5189: tetrapyrrole biosynthesis II (from glycine)]
our results highlighted a higher log ratio of Veillonella atypica + Porphyromonas gingivalis to Actinomyces sp
ICM47 + Actinomyces SGB17157 in the saliva of the PI group compared to the HI group
gingivalis as core bacterial species in the dental plaque microbiome
their specific roles in the PI microbiome remain unclear
showing elevated levels of a combination of P
provide a foundation for further investigation into their potential contributions to PI pathogenesis
Functional pathways capture the collective metabolic activities of microbial communities
changes in the microbiome are reflected in changes in functional pathways
We could find combinations of functional pathways that were more linked to PI and others to peri-implant health
Pathways associated with arginine and polyamine biosynthesis
and citrulline biosynthesis were correlated with PI
A major limitation of most studies investigating the human oral microbiome
often constrained by the high costs associated with sequencing methods
particularly shotgun metagenomic sequencing
Given the highly individualized nature of the oral microbiome
future research should prioritize larger and more diverse cohorts spanning various regions and countries to enhance the generalizability and applicability of the findings
Further longitudinal studies are needed to explore changes in the oral microbiome during the transition from health to disease to advance precision and personalized medicine (Belibasakis et al., 2019). The development of tools for individualized microbiome profiling (personalized metagenomics) holds great potential for applications in microbiome-based medicine (Kim et al., 2024)
Our findings indicate that healthy implants in an oral cavity without any PI-affected implants show distinct microbial signatures compared to healthy implants co-occurring with PI-affected implants in the same oral cavity
The bacterial species and functional pathways associated with healthy implants co-occurring with PI-affected implants more closely resemble those related to PI than those associated with healthy implants in PI-free oral cavities
This suggests that the microbiome and functional profile of implants diagnosed as healthy differ depending on their context within the oral cavity
these microbial and functional biomarkers follow the same pattern in salivary samples
PI-affected implants may serve as a reservoir for a different microbial niche
influencing changes in the microbiome of healthy implants and saliva
These findings also highlight saliva’s potential as a convenient and non-invasive medium for identifying biomarkers related to PI diagnosis and prevention
With ongoing advancements in metagenomics and studies like ours
there is a growing opportunity to identify biomarkers that can be validated and translated into clinical applications
This has the potential to greatly enhance early diagnosis
Such advancements are of significant clinical importance
paving the way for potential breakthroughs in understanding and managing PI
with important implications for both clinicians and researchers
The datasets presented in this study can be found in a online repository, NCBI SRA database, under accession number PRJNA1163384 (https://www.ncbi.nlm.nih.gov/sra/?term=PRJNA1163384)
The studies involving humans were approved by Egas Moniz Ethics Committee,Egas Moniz School of Health & Science(process number 1123)
The studies were conducted in accordance with the local legislation and institutional requirements
The participants provided their written informed consent to participate in this study
The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by Portuguese National Funds provided by the FCT (Fundação para a Ciência e Tecnologia) under the project "Metagenomic snapshot of the microbiome and resistome in peri-implantitis: pilot study”, with the grant number: 2022.01430.PTDC (http://doi.org/10.54499/2022.01430.PTDC)
The authors would like to thank Egas Moniz Dental Clinic for its assistance with this project
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
The author(s) declared that they were an editorial board member of Frontiers
This had no impact on the peer review process and the final decision
The author(s) declare that no Generative AI was used in the creation of this manuscript
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article
or claim that may be made by its manufacturer
is not guaranteed or endorsed by the publisher
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2025.1543100/full#supplementary-material
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Biotin deficiency induces intestinal dysbiosis associated with an inflammatory bowel disease-like phenotype
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Periodontal and peri-implant microbiome dysbiosis is associated with alterations in the microbial community structure and local stability
Identification and characterization of a haem biosynthesis locus in Veillonella
Veillonellae: beyond bridging species in oral biofilm ecology
Mendes JJ and Alves R (2025) Linking peri-implantitis to microbiome changes in affected implants
Received: 10 December 2024; Accepted: 26 March 2025;Published: 17 April 2025
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Francisco Castro passed away peacefully in Oakland
He was born to Henrique Coelho Castro and Vitalina Alves Azevedo in Ribeirinha
They had four beautiful children and 10 beautiful grandchildren
and worked in the dairy industry for 35 years
go to the bullfights (where he became a director)
and he enjoyed spending time at the casino
He served as the President of CPSC in 1987
and he was a member of the Azores Band of Escalon for 20 years
He loved his goats and livestock and enjoyed making goat cheese
He was a San Francisco Giants and a San Francisco 49ers fan
In conjunction with his love of those teams
and truly enjoyed watching his grandkids play sports
Francisco is preceded in passing by his loving parents Henrique Coelho Castro
Vitalina Alves Azevedo and his brother Jose Henrique Castro
He is survived by his beloved wife Darlene (Borba) Castro of 45 years and their children Sabrina Silva of Manteca
and Derek Castro (Charlotte Castro) of Galt
He also leaves behind his beautiful grandchildren; Haylee Castro
He is also survived by his sister Vitalina Serpa of Visalia
Deegan Funeral Chapel is honored to serve the Castro family
A visitation will be held at Deegan Funeral Chapel in Escalon on May 16
A Rosary and Funeral Mass will be held at St
Memorial donations in honor of Francisco Castro can be made to the ALS Association
Here’s how coworking spaces around the world are marking this year’s coworking anniversary
Suggested Reading: International Coworking Day 101: Everything You Need to Know About 9th August
9th August has become recognised as the day that “coworking” was born
a coworking space owner from BeesOffice in Rio de Janeiro
and some other members of a Coworking Google Group forum
who decided to mark August 9th as International Coworking Day
it’s an opportunity to throw open their doors and raise awareness of the benefits of coworking to their local communities
and Cat Johnson from the Coworking Content Alliance
Allwork.Space reached out to workspace owners to find out how they’re marking this year’s coworking anniversary
In New Bedford, MA, Groundwork is celebrating by offering free coworking all day to the public along with refreshments
ice cream sundaes and chair massages courtesy of a new local cafe
which partnered with Groundwork to create a coffee pop-up stall for the day
“We also asked members to tell us their favorite tunes
so that we can create a member faves playlist to play throughout the day,” said Groundwork’s Caitlin Joseph
In San Juan, Puerto Rico, CoCo.Haus is running a full day event starting with a round table breakfast served by a barista
followed by a talk on productivity and a sprint work session
then a lunch and learn entrepreneurship panel where 5 of members talk about their stories and industries
“We’re finishing with a big happy hour with other members of the larger community at a nearby gastropark,” said founder
Novel Coworking will be offering a free day of coworking nationwide in celebration of International Coworking Day
as well as hosting in-center community events with food
At EnerSpace
the team are doing an “Around the World” happy hour and a free coworking day
In Winnipeg, Canada, Canoe Coworking’s Tara Everett says:
“Three spaces are collaborating at one (one is open
and the other two are in development) with a lunch and a panel to build awareness
community and education about coworking and its amazing benefits.”
In Oklahoma, business center brand PC Executive Services is offering free coworking day passes
and a giveaway for private day office passes at both of its Oklahoma City and Edmond locations
In Mumbai, India, the Ministry of New is celebrating its members by treating them to lunch
and they’ll be seated at a 50ft long communal table in the courtyard
“This year’s theme at Ministry Of New is ‘Connecting the Dots’,” says Marlies Bloemendaal
“During lunch we will introduce our next ‘mastermind sessions’
where we tap into our collective experience and networks to tackle certain issues in our city
In Preston, UK, Society1 is offering a day of free coworking to local business owners who haven’t tried it before
because “sitting at home on your own is boring.”
Allison Blevins of FACTORY explains how they’re using International Coworking Day to work together with other spaces in the Grane Valley and inspire a little exploration:
“We’ve teamed up with other coworking spaces in our valley to create the Grand Valley Progressive Workday
We had a map designed and we are encouraging workers to visit each space throughout the day
The first person to visit all five spaces will win three months of coworking!”
FACTORY is also adding a bit of fun by offering a prize draw entry to members who complete their profiles
There will also be an ice cream top-it party during the afternoon and a happy hour at the end of the day
The team at WorkSuites is giving away 19 one-month coworking memberships for their newly expanded Uptown Cole space and The Woodlands in Houston
“We have 19 locations so that is why we chose 19 memberships
We will also have ‘Kolaches and Coworking’ at each of our locations on Friday morning.”
Canadian brand Coworkly is offering free coworking for the day and is also setting up an outdoor pop-up space by placing desks on the main street outside the building
In Brisbane, Australia, Central Business Associates is welcoming new
previous and existing coworking members to come along and be a part of their flexible workspace community for the day
Coworking first-timers can enjoy a free trial in the space
while former and current members receive discounted rates for the day
hygge coworking in Charlotte
is laying on breakfast and spending the day showing appreciation for the community that they’ve built within their walls
“Zero Day is our monthly community event which will be held this Friday
and focuses on taking a moment away from work to be open to meeting someone new
It’s collaborative and many new connections are formed — which only help in growing the event and the bond within the hygge walls.”
Spaces Working Together to Celebrate International Coworking Day
In addition to independent events, a number of coworking spaces are hosting coordinated events. Among them, several members of New Work Cities are hosting coordinated Work Sprints, while the Kansas City Coworking Alliance has planned an afternoon of games and refreshments with friends and family members of the KC Coworking Alliance member spaces
The Atlanta Coworking Alliance is enjoying an extra celebration, as the city has proclaimed August 9th ‘Atlanta Coworking Day’
led by the newly formed Atlanta Coworking Alliance
is described as “a huge win for our independent coworking communities” with spaces coming together to host various public and member activities throughout the week
The Women Who Cowork alliance, founded by Iris Kavanagh and Laura Shook Guzman, is taking the opportunity to encourage people to go out and support their local women owned coworking communities, which they are coordinating via social media
“Women Who Cowork is celebrating our 3rd anniversary and taking this week to focus on the question ‘Why are we doing this now
Why are we called to do this work now?’” – which includes a Facebook live discussion between Iris and a number of coworking members on Friday
Both Laura and Iris are also hosting events at their own spaces
there will be a free day of wellness coworking “to support a day of work/life balance” complete with a free Yoga Nidra class and chair massage
What are you doing to celebrate International Coworking Day? Let us know by tagging Allwork.Space in your updates and photos on Facebook, Twitter, Linkedin or Instagram
Despite a challenging economic environment
New Zealand's coworking and flexible workspace market has demonstrated notable resilience
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Brazilian architects Estudio America won a competition in Salvador for the refurbishment and expansion of the Castro Alves Theatre. More images and architect’s description after the break.
A theatre is part of those initiatives that play an essential role in a people’s cultural life. With its public character, by definition, sites where performances take place have in fact a significant function in the structuring of cities and territories which they irrigate culturally.
The connection between the addition and the existing building was possible by the creation of two separate flows of functional services and general public
establishing a coherent and balanced dialogue which brings potential to the use of the physical space
At the so called “Café Teatro” the original design was intended to be recovered, but adapted to contemporary needs, as it was once a perfect fit to the foyer.
The main room, dressing room and the stage support areas were redistributed, for a clearer organization. The stage area will have the requested requalification, to meet more freely the scenic changes. The audience will be reorganized, for both allocation of seats and for finishes, according to the most modern materials and techniques of acoustic treatment.
Along the length of the rear facade of the theater
The proposal meets what was required by the program
but a very workable solution will allow twice as many parking places than what was required
thus facilitating its commercial exploitation
The bicycle racks have been strategically positioned to better receive the flow of this type of vehicles
considering its existence as an opportunity to encourage changes in the transport mode of the population
Authors Carlos Eduardo García Guilherme Motta Lucas Fehr (Registered Architect) Marcus Vinicius Damon Mario Figueroa
Vicente Deeke Boguszewiski Amanda Renz Juliana Baldocchi Kalina Juzwiak Luiza Monserrat Mario do Val Renata Santoniero Tiago Collet
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The COVID-19 pandemic threatens indigenous peoples living in suburban areas of large Brazilian cities and has thus far intensified their pre-existing socio-economic inequalities
We evaluated the epidemiological situation of SARS-CoV-2 infection among residents of the biggest urban multiethnic indigenous community of the Amazonas state
Blood samples of 280 indigenous people living in the surrounding area of Manaus were tested for the presence of anti-SARS-CoV-2 IgA or IgG antibodies
The risk factors and sociodemographic information were assessed through an epidemiological questionnaire
We found a total positivity rate of 64.64% (95% CI 59.01–70.28) for SARS-CoV-2 infection
IgA and IgG were detected in 55.71% (95% CI 49.89–61.54) and 60.71% (95% CI 54.98–66.45) of the individuals
Over 80% of positive individuals were positive for both IgA and IgG.No significant difference in positivity rates between genders or age groups was observed
the age group ≥ 60 years old showed the highest antibody ratios (IgA mean ratio = 3.080 ± 1.623; IgG mean ratio = 4.221 ± 1.832)
while the age groups 13–19 and 20–29 showed the lowest IgA (mean ratio = 2.268 ± 0.919) and IgG ratios (mean ratio = 2.207 ± 1.246)
Individuals leaving the home more frequently were at higher risk of infection (Odds ratio (OD) 2.61; 95% CI 1.00–1.49; p = 0.048)
Five or more individuals per household increased fivefold the risk of virus transmission (OR 2.56; 95% CI 1.09–6.01; p = 0.019)
The disproportionate dissemination of SARS-CoV-2 infection observed among the study population might be driven by typical cultural behavior and socioeconomic inequalities
this population is not being targeted by public policies and appears to be chronically invisible to the Brazilian authorities
This situation put indigenous communities under worrying threat during public health emergencies
This population is completely invisible to the Brazilian public health agenda
this study assessed the magnitude of the spread of SARS-CoV-2 and its transmission risk factors among the biggest multiethnic urban indigenous community located on the west side of Manaus
This study was approved by the Brazilian Commission for Ethics in Research-CONEP (approval number: 4.260.763)
All individuals signed the informed consent form before taking part in this study
An informed consent was obtained from a parent and/or legal guardian of the participants under the age of 18 years old
The confidentiality and the right to leave the study at any time were guaranteed to all participants
All experiments were performed in accordance with relevant guidelines and regulations
we randomly recruited indigenous residents in the community of Parque das Tribos
the biggest multiethnic urban indigenous community in Manaus
Over 1300 indigenous people from 35 different ethnicities live in this community
This study applied consecutive sampling as a selection strategy and the sample size was statistically estimated using a 95% confidence interval
Flow chart shows study design and the number of individuals included
The optical density was measured in a spectrophotometer (Epoch Microplate
and the test positivity was determined according to the cut-off formula indicated by the manufacturer
Cut-off ranges were obtained by calculating a ratio of the optical density (OD) values of the control or patient sample over the OD of the calibrator
according to the following formula: OD of the control or patient sample/OD of calibrator = ratio
Ratios < 0.8 were considered negative and ratios ≥ 1.1 positive
Ratios 0.8≥ to < 1.1 were considered borderline
Individuals with borderline results were retested twice within 2–4 weeks
the specificity and sensibility for anti-S IgG ≥ 21 days post-symptom onset are 100% and 99.3%
the specificity is 100% and sensibility is 92.4%
Serological tests were performed at the Laboratory of Virology and Immunology of the National Institute of Amazonian Research (INPA)
All the patients included in this study signed a written consent form
All authors have read and agreed to the published version of the manuscript
Ethnic diversity of the study population and positivity rates
(A) SARS-CoV-2 positivity according to ethnicity
IgG and IgA/IgG positivity among infected individuals
Smaller dots represent the antibody ratio from each individual
Larger dots and vertical lines represent mean and standard deviation
Dashed line represent cut-off values specified by the manufacturer
Main clinical symptoms and pattern of positivity according to the day of onset of the individual’s symptoms
(A) Number of symptomatic and asymptomatic individuals positive for SARS-CoV-2
(B) IgA and IgG positivity rates according to the day of the onset of the symptoms
Number 0 means the individuals presented symptoms on the day of blood collection
Dots and vertical lines represent mean and standard deviation
The total positivity rates were similar between women and men (p = 0.207) and no significant differences between age groups were observed (Table 1)
when the IgG positivity rates were compared based on antibody ratios
the difference observed between the following age groups was statistically significant: ages 20–29 and 40–49 (p = 0.044); 13–19 and ≥ 60 (p = 0.002); 20–29 and ≥ 60 (p = 0.0004) (Supplementary 1A)
People belonging to the age group ≥ 60 years old showed the highest antibody ratios (IgA mean ratio = 3.080 ± 1.623; IgG mean ratio = 4.221 ± 1.832)
These values may indicate the serum level of antibodies in these individuals
in order to confirm this information it is necessary to perform antibody titration
we were not able to assess the antibody serum levels
The main reasons for leaving the home were either to work or buy food
(A) Association between the risk of exposure to infection and the household size (number of members)
(B) SARS-CoV-2 prevalence rates according to the number of inviduals per resindence
(A) Purchasing power and behavior characteristics (B) of study population
the effectiveness of pandemic response management demands a better comprehension on the impact of social asymmetries in relation to SARS-CoV-2 exposure risk within different population groups
especially amid ethnic minorities living in poverty
such as the indigenous populations of this region
These data clearly show that indigenous people are disproportionately hit by SARS-CoV-2 infection
This scenario might be a result of social vulnerabilities
which in turn maximize dissemination of the virus and put this population at greater risk
This population struggles to adopt measures to prevent and mitigate the SARS-CoV-2 spread since they have limited access to basic services like adequate sanitation and clean water
The study population was composed of families of low education and income levels
Our findings showed that over 95% of the residents of Parque das Tribos had no access to clean drinking water and adequate sanitation
The precarious and chaotic social conditions of the study population could be the main reason for the high positivity rates observed
we did not follow up the study population to observe the clinical outcome of the infection
More comprehensive studies are necessary in order to confirm this speculation
The authors suggested that these age groups might be more susceptible or exposed to SARS-CoV-2 infection because they are working adults who must leave home to support their families
we observed that the individuals of the study population who left home more often (2–4 times a week) had an increased infection risk
The main reasons for leaving home were either to work or to buy food
Our findings demonstrated that individuals living in households with six or more people had an almost fivefold increase in risk
This situation is worsened by poor-quality housing
The dwellings of Parque das tribos are very small buildings constructed with low-quality materials
without essential basic infrastructure such as a supply of safe drinking water or effective sewerage
housing conditions are completely inadequate for keeping them safe from many communicable diseases
Our data also showed that most of the individuals partially trust the information coming from the Brazilian government
the use of herbs can cause a false sensation of protection
which may result in the discontinuation of important measures to prevent COVID-19 and enhance the vulnerability of these populations
this study indicates that indigenous peoples living in urban areas are being dramatically affected by SARS-CoV-2
especially because of their poor socioeconomic conditions and lack of access to adequate health assistance
This population is fighting a double battle due to the fact that a) in the Brazilian national health system (SUS)
their indigenous identity is not recognized by the patient management system and b) They are not assisted by SESAI because they are outside their villages or reservations
Both situations reinforce the invisibility of these populations
we need coordinated national actions that prioritize ethnic vulnerable groups in the battle against COVID-19
We need public policies that promote health
adequate housing and sanitation for these populations
indigenous people living in urban areas are doomed to suffer at unprecedented levels during the current pandemic
All data generated or analyzed during this study are included in this published article and its supplementary information files
Population and environment in Amazônia: Landscape and household dynamics
IBGE. Senso demográfico IBGE. Inst. Bras. Geogr. e Geoestatistica. https://biblioteca.ibge.gov.br/index.php/bibliotecacatalogo?view=detalhes&id=264529 (2010)
The challenges facing indigenous communities in Latin America as they confront the COVID-19 pandemic
Under-reporting of COVID-19 cases among indigenous peoples in Brazil: A new expression of old inequalities
Response quality in survey research with children and adolescents: The effect of labeled response options and vague quantifiers
World Health Organization. Clinical management of COVID-19: interim guidance. World Health Organization. https://apps.who.int/iris/handle/10665/3321969 (2020)
World Health Organizationzation. Operational considerations for case management of COVID-19 in health facility and community: interim guidance. https://apps.who.int/iris/handle/10665/331492 (2020)
Aziz, N. A. et al. Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany. Nat. Commun. [Internet] Springer US 12, 1–10. https://doi.org/10.1038/s41467-021-22351-5 (2021)
and COVID-19: Evidence from a fuzzy multidimensional analysis of deprivations in Brazil
High prevalence of anti-SARS-CoV-2 IgG antibody in the Xikrin of Bacajá (Kayapó) indigenous population in the Brazilian Amazon
SARS-CoV-2 seroprevalence and associated factors in Manaus
Brazil: Baseline results from the DETECTCoV-19 cohort study
SARS-CoV-2 antibody prevalence in Brazil: Results from two successive nationwide serological household surveys
Structure and function relationships in IgA
Enhanced SARS-CoV-2 neutralization by dimeric IgA
IgA dominates the early neutralizing antibody response to SARS-CoV-2
Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients
Antibody responses to SARS-CoV-2 in patients with COVID-19
Age groups that sustain resurging COVID-19 epidemics in the United States
COVID-19 and Brazilian indigenous populations
SÁUDE INDÍGENA EM TEMPOS DE BARBÁRIE: Política pública
Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea
Echinacea-A source of potent antivirals for respiratory virus infections
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The authors thank the community chief Miqueias Kokama and the community residents Vanderlecia Ortega dos Santos
Alcinea Martins Albuquerque and Ana Cláudia Martins Tomas for all support provided during this study
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) under Finance code PROCAD AMAZÔNIA 88881.200581/201801
Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM-Pró-Estado Program) and Rede Corona-ômica BR MCTI/FINEP affiliated to RedeVírus/MCTI (FINEP = 01.20.0029.000462/20
Instituto Nacional de Pesquisas da Amazônia (INPA)
Anderson Nogueira Barbosa & Ana Carla Bruno
Programa de Pós-Graduação em Imunologia Básica e Aplicada
Carlos Eduardo de Castro Alves & Allyson Guimarães da Costa
Programa de Pós-Graduação em Ciências Aplicadas à Hematologia
Leonardo Calheiros de Oliveira & Allyson Guimarães da Costa
Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Amazônia Legal-PPG-BIONORTE
and A.N.B.; writing—original draft preparation: G.S.P.
and R.P.-S.; writing—review and editing: G.S.P
and A.G.C.; supervision: G.S.P.; project administration
The authors declare no competing interests
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
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DOI: https://doi.org/10.1038/s41598-021-96843-1
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by FABIANO MAISONNAVE | The Associated Press
Brazil (AP) — Brazilian federal agents aboard three helicopters descended on an illegal mining site on Tuesday in the Amazon rainforest
leaving behind an increasingly familiar find for authorities: Starlink internet units
Agents from the Brazilian environment agency's special inspection group and the federal highway police rapid response group on Tuesday found one Starlink terminal up and running next to a pit, an officer who participated in the raid told The Associated Press. He spoke on condition of anonymity over concerns for his personal safety.
They also seized mercury, gold and ammunition, and destroyed fuel and other equipment used by miners in an area known as Ouro Mil, controlled by Brazil´s most feared criminal organization, known as the First Command of the Capital, according to federal investigations.
Since taking office this year, President Luiz Inácio Lula da Silva has sought to crack down on environmental violations, particularly illegal mining in Yanomami land, Brazil's largest Indigenous territory. In recent years, an estimated 20,000 prospectors contaminated vital waterways with mercury used to separate gold. They have disrupted traditional Indigenous life, brought disease and caused widespread famine.
The environment agency, known as Ibama, has seized seven Starlink terminals in Yanomami land over the past five weeks, the agency's press office said.
Illegal miners have long used satellite internet to communicate and coordinate, but until now that entailed sending a technician, usually by plane, to install a heavy, fixed antenna that cannot be carried off when mining sites move or are raided. And the connection was slow and unstable, especially on rainy days.
Starlink – which first became available in Brazil last year and has spread rapidly – solved those problems. Installation is do-it-yourself, the equipment works even on the move, speed is as fast as in Brazil´s large cities and it works during storms.
Starlink has long viewed the Amazon as an opportunity. That was underscored by Musk's visit to Brazil last May, when he met with then-President Jair Bolsonaro.
That project with the government hasn't advanced, however. SpaceX and the communications ministry haven't signed any contract, and only three terminals were installed in Amazon schools for a 12-month trial period, the ministry's press office said in an emailed response to questions.
Nevertheless, Starlink has taken off in the region and begun ushering in change.
In Atalaia do Norte, on the western reaches of the Brazilian Amazon near the borders with Peru and Colombia, Rubeney de Castro Alves installed Starlink at his hotel in December. Now, he can make bank transfers and conduct video calls. He even started bingeing on Netflix.
"There are so many new things to watch that I'm not even sleeping," Alves said, chuckling.
His son once flew all the way to Manaus, the state capital 1,140 kilometers (708 miles) away, just to negotiate with a group of tourists via conference call. Today, internet at his 11-room hotel in Atalaia do Norte is more reliable than in Manaus, and he bought a second terminal for his tour boat to enable communications on its 10-day voyages, Alves said.
With high demand for internet, dozens of the riverside town's 21,000 residents flock to Alves' hotel each day. Its balcony is a meeting point for teenagers who spend hours playing online games on their phones.
A world away, in Ukraine, Starlink has yielded advantages on the battlefield in its war with Russia.
Ukraine has received some 24,000 Starlink terminals that allow continued internet in the most vulnerable regions of the southeast even amid ongoing Russian shelling. In large Ukrainian cities, authorities have set up "points of resilience" that offer free internet along with hot beverages.
The benefits of connectivity were immediately apparent to bad actors in the Amazon, Hugo Loss, operations coordinator for Brazil´s environment agency, told the AP in a phone interview.
Another official with the environment agency told AP it is just beginning to expel miners from the Yanomami territory and the spread of Starlink has complicated that mission. The official spoke on condition of anonymity because of concerns about personal safety.
An unauthorized reseller of Starlink in Boa Vista, the gateway for travel into Yanomami territory, has been marketing the units in a WhatsApp group for illegal miners and promising same-day delivery. Her price for a terminal is $1,600— six times what Alves pays for service at his little hotel in Atalaia do Norte. Others are selling the Starlink terminals on Facebook groups for illegal miners, like one called "Fanatics for Prospecting."
As lawbreakers have gained access to superior internet service, authorities have started using Starlink themselves. Federal agents installed a terminal at a new checkpoint on the Uraricoera River – an important corridor for miners entering Yanomami territory. The official who informed the AP about the Tuesday raid used Starlink to send photos and even heavy video files of their operation.
Brazil's environment agency told the AP via email that it, along with other federal bodies, is studying how to block Starlink's signal in illegal mining areas, calling it crucial to stopping the activity.
The AP emailed James Gleeson, SpaceX's Communications Director, questions about Starlink's presence in Brazil and its use by illegal miners in remote areas, but received no response.
AP journalist Yuras Karmanau contributed from Tallinn, Estonia.
Self-taught intellectual wrote poetry and essays, in addition to translating the works of other important authors
Ormuzd Alves/Folhapress José Paulo Paes, in 1991, in his home library in the city of São PauloOrmuzd Alves/Folhapress
Family's personal collection Paes and the literary critic Alfredo Bosi (in a suit), who became friends in the 1960sFamily's personal collection
Family's personal collection With his wife, ballerina Dora Costa, to whom he dedicated his second book, Cúmplices, in 1951Family's personal collection
Family's personal collection Paes (wearing glasses) at an event (undated) attended by Bahian novelist Jorge Amado (at the microphone)Family's personal collection
Paes, who worked in the publishing sector as an editor at Cultrix in São Paulo from the 1960s to the 1980s, was mild-mannered in nature, which may have contributed to his work receiving little attention from scholars. Among the few reviews of the author are, for example, a preface by Alfredo Bosi for the anthology Um por todos (One for all), published in 1986 by Editora Brasiliense, and another by literary critic Davi Arrigucci for the anthology Os melhores poemas (The best poems; Global, 1998).
Reproduction Book covers for some books written by the author
The work Um passarinho me contou won the Jabuti prize in 1997Reproduction
Paes’s poems were marked by the memorialist tone he adopted to delve into his childhood and evoke family memories of Taquaritinga in the book Prosas seguidas de odes mínimas (Prose followed by minor odes; Companhia das Letras
This stylistic turn coincided with a tragic biographical event: the amputation of his left leg due to a circulatory issue
which he inherited from Drummond and carried throughout his life
prevented the poet from surrendering to cheap sentimentality: “Legs/ for what do I want you?/ If I no longer have/ anything to dance for./ If I no longer want/ to go anywhere anymore./ Legs?/ One is enough,” he writes in “Ode to my left leg.”
Twenty-five years after José Paulo Paes’s death
academic studies on the author are expected to become more in-depth with the incorporation of his collection at IEB-USP
“We want to focus on Paes’s essays that were left out of the collection and continue researching him,” concludes Paixão
© Revista Pesquisa FAPESP - All rights reserved.
CITRUS HEIGHTS CALIFORNIA STAKE: (June 17, 2019) President — Robert Cameron Martell, 53, owner and operator, Awesome Pool Services; succeeding Ned P. Telford; wife, Karen Bailey Martell. Counselors — Richard Scott Newey, 59, owner, Route 40 Classics; wife, Dayna Darlene Wills Newey. Daniel Austin Bills, 62, director of finance and administration, Sacramento Suburban Water District; wife, Karen Coleman Bills.
CURITIBA BRAZIL TARUMA STAKE: (June 9, 2019) President — Antônio Carlos Ribeiro Cavalcanti, 57, partner, A&C Educação Corp.; succeeding Gerson de Castro Alves; wife, Célia Regina Pires Cavalcanti. Counselors — Wesley de Castro Rocha, 44, video producer; wife, Luciane Dombeck Rocha. Davi Fernandes Goveia Ramos, 49, micro entrepreneur, Vectron Automação; wife, Eliane Alves Goveia Ramos.
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Volume 11 - 2020 | https://doi.org/10.3389/fpls.2020.610011
This article is part of the Research TopicCrop Physiology under LED LightingView all 23 articles
Ultraviolet B (UV-B) (280–315 nm) and ultraviolet A (UV-A) (315–400 nm) radiation comprise small portions of the solar radiation but regulate many aspects of plant development
how plants respond to UV-B in the presence of different light qualities is poorly understood
This study aimed to assess the effects of a low UV-B dose (0.912 ± 0.074 kJ m–2 day–1
at a 6 h daily UV exposure) in combination with four light treatments (blue
red and broadband white at 210 μmol m–2 s–1 Photosynthetically active radiation [PAR]) on morphological and physiological responses of cucumber (Cucumis sativus cv
We explored the effects of light quality backgrounds on plant morphology
and on acclimation ability to saturating light intensity
Our results showed that supplementary UV-B significantly decreased biomass accumulation in the presence of broad band white
UV-B also reduced the photosynthetic efficiency of CO2 fixation (α) when combined with blue light
despite showing high accumulation of anthocyanins
were unable to cope with saturating light conditions
No significant effects of UV-B in combination with green light were observed for gas exchange and chlorophyll fluorescence parameters
but supplementary UV-B significantly increased chlorophyll and flavonol contents in the leaf epidermis
Plants grown under red light and UV-B significantly increased maximum photosynthetic rate and dark respiration compared to pure red light
red and UV-B treated plants exposed to saturating light intensity showed higher quantum yield of photosystem II (PSII)
fraction of open PSII centres and electron transport rate and showed no effect on the apparent maximum quantum efficiency of PSII photochemistry (Fv/Fm) or non-photochemical quenching
in contrast to solely red-light conditions
These findings provide new insights into how plants respond to UV-B radiation in the presence of different light spectra
although the response of these photoreceptors to green light is extremely weak compared to red and blue radiation
rely on the sole use of LEDs and provide a unique environment for investigating new opportunities of LED lighting use
such as in monochromatic illumination and the use of UV to manipulate plant growth and development
Cucumber (Cucumis sativus L.), is an important food crop with fast growth and high sensitivity toward the spectral composition of the light environment. These aspects make cucumber an interesting crop for studying light-driven responses in plants, such as responses to UV radiation (Qian et al., 2019, 2020)
The aim of this study was to investigate the effects of supplementary UV-B on growth
morphology and physiology of cucumber plants grown under different monochromatic light backgrounds
We hypothesized that: (I) different monochromatic lights have different impacts on plant morphology and (II) the response of cucumber to UV-B radiation is highly dependent on individual monochromatic light backgrounds
creating a daily light integral (DLI) of approx
Because of the comparatively low photosynthetic photon flux efficacy from green LEDs the green FL300 lamp was complemented by two custom-made narrow
To eliminate stray light the sides of the trolleys were covered with non-transparent black/white plastic with the white side facing inward
the position effect within each treatment was minimized by randomizing the treatment pots daily
Photosynthetically active radiation of four different light backgrounds (broadband White
The plant-weighted UV normalized to 300 nm was quantified to 42.4 ± 3.4 mW m–2
corresponding to 0.912 ± 0.074 kJ m–2 day–1 (at a 6 h daily UV exposure)
Plants were exposed to UV-B radiation for 14 days
Thereafter 22 plants per treatment were measured and harvested (see below)
To investigate whether the different light acclimation regimens induced a difference in the ability to cope with photoinhibition
the remaining treatment plants were subjected to a saturating light treatment for 5 h at 1600 μmol m–2 s–1 PAR provided by two FL300 Sunlight luminaires
delivering an additional light integral of 29 mol m–2 5 h–1
Figure 1. (A) Spectral irradiance (in W(cm2 nm)–1) in Perspex covered (control) and cellulose acetate covered (UV-B) boxes under four different PAR backgrounds (Table 1); broadband White (gray line)
Red (with lines of respective color) and UV-B (violet line)
(B) Spectral irradiance in the UV range (violet line) with enlarged scale and the plant-weighted UV dose (black dotted line) in the UV-B treatments
Plant growth was assessed for 5–7 plants per treatment through destructive harvest at the end of the UV-B radiation treatment
The plant height was measured from the stem base to the apical meristem and the stem diameter (Ø) 1 cm above the soil using a digital slide caliper (Biltema
The number of true leaves and leaf area (LA) was measured on scanned leaves using the Image J software (version 1.52a) (Wayne Rasband
leaf and stem fresh mass (LFM and SFM) and dry mass (LDM and SDM) were determined after drying for 3 days at 80°C
individual leaf area (ILA = LA/leaf number)
internode length (INL = height/leaf number) and dry mass per cent (DM% = total DM/total FM) were calculated
the apparent quantum yield of CO2 assimilation based on incident light (α)
maximum net assimilation rate at light saturation (Amax)
and the convexity (θ) of the light response curve
Non-destructive measurements of chlorophyll
flavonol and anthocyanin contents were assessed on the adaxial side of the last fully developed leaf with a Dualex+ (FORCE-A
The four replicates per treatment were measured immediately after the daily UV-B exposure
Biomass accumulation of cucumber plants grown under four PAR backgrounds after 14 days without (solid bars) or with (dashed bars) exposure to supplementary UV-B irradiation
(A) Height (cm); (B) Internode length (INL
Capital letters indicate significant differences between growth light qualities without UV-B and lower-case letters between non-UV-B-exposed plants and UV-B-exposed plants within the same light backgrounds
(A) Fitted light response curves of cucumber grown under four LED light backgrounds (White
and Red) without (solid bars) and with (dashed bars) exposure to supplementary UV-B radiation for 14 days [for variation of the data at light saturation refer from panels (B–F)]
Curve fitted parameters: (B) Maximum net assimilation rate (Amax); (C) Dark respiration (Rdark); (D) Light compensation point (LCP); (E) Apparent quantum yield of photosynthesis (α); and (F) convexity (θ)
Bars represent the mean values (n = 21 ± SE)
Capital letters indicate significant differences between growth light qualities without UV-B and lower-case letters between non-UV-B-exposed plants and UV-B-exposed plants within the same PAR background
Chlorophyll fluorescence parameters measured in cucumber plants grown under four different PAR qualities (White
and Red) and without (solid bars) or with (dashed bars) exposure to supplementary UV-B radiation for 14 days
prior to and after a 5 h saturating light treatment (1600 μmol m–2 s–1)
(A) Maximum photochemical efficiency (Fv/Fm); (B) Apparent electron transport rate (ETR); (C) Fraction of oxidized PSII (qL)
Bars represent mean values (Before saturating light: n = 21 ± SE; After saturating light n = 15 ± SE)
Capital letters indicate significant differences between growth light qualities without UV-B and lower-case letters between non-UV-B-exposed plants and UV-B exposed plants within the same PAR background
(B) flavonol and (C) anthocyanin content of cucumber plants
and grown under different light quality backgrounds (White
blue-light-grown plants are able to efficiently use photosynthates for growth
If comparing plants grown in white or green light by putting the values of TDM
TLA and Amax to 1 for white-light-grown plants
the relative values for the green-light-grown plants will be TDM = 1.07
If these numbers are used to calculate a very crude estimation of the total canopy Amax
without taking internal shading and light acclimation into consideration
the white-light-grown plants will have canopy Amax of 1 × 1 = 1
while the green-light-grown plants will have 1.65 × 0.65 = 1.07
This crude relative photosynthesis rate at light saturation on canopy level actually fits to the relative TDM for the green-light-grown plants
In nature, a green-light-enriched environment is an indication of overgrowing vegetation triggering a shade-avoidance response resulting in stem elongation and upward leaf orientation (Zhang et al., 2011; Zhang and Folta, 2012; Wang et al., 2015). Moreover, Folta (2004) suggested that supplementary green light irradiation induces early hypocotyl elongation
Inhibition of stem elongation is a phytochrome-dependent response
and the wavelengths of our green growth light fall precisely outside the range of the phytochrome action spectrum
thus simulating a light environment lacking the red wavelengths
green light grown plants were significantly taller than the plants grown under red and broadband white light
This suggests that plants grown under green light
in addition to having thinner and larger leaves
also tried to optimize light absorption by growing taller in response to a red-depleted light environment
While blue growth light did not change any of the plants’ photosynthetic parameters compared with plants grown in white light, plants grown under green light showed decreased Amax, Rdark, and LCP, while maintaining α and θ at the same levels as plants grown in white or blue light (Figure 3). All these changes correspond to low-light acclimation of photosynthesis (Givnish, 1988)
resulting in an NPQ increase in proportion to ETR
Plants grown under green light showed a large decrease in the light saturated Amax compared with plants grown in white light
at the lower growth irradiance (210 μmol m–2 s–1) the decrease of An was considerably smaller
Since the total biomass production was even higher in plants grown under green light than in plants grown under white PAR
this suggests that the green-light-grown-plants were not source limited
The low NPQ of red-light-grown cucumber suggests a low heat dissipation
which could be associated with a strong down-regulation of the photosynthetic process
impairment of photosynthesis could explain the growth inhibition observed in cucumber grown under red light
manifested as plants with the smallest stem Ø and lowest biomass accumulation (LDM
and TDM) compared with plants grown under the other light qualities
Red-light-grown cucumber also had highest LMR
suggesting that the plants allocated as many resources as possible toward leaves to mitigate growth inhibition
NPQ decreased in plants grown under all different monochromatic light qualities
indicating that energy dissipation due to down-regulation of PSII increased
at the expense of light-regulated heat dissipation (NPQ)
campanulas and chrysanthemums with an increasing proportion of blue light in a red background light
in contrast to a low flavonoid content in plants grown under monochromatic red light
as well as the decreased Fv/Fm and α suggest that the red light is a stress factor in cucumber
but that the accumulated anthocyanins were insufficient to protect the leaves from light stress by the red growth light
This may be due to different levels of UV-B used in in different studies
as well as the use of different UV-B to PAR ratios
Cucumbers appear less susceptible to low levels of UV-B when grown in green light
since a decrease in NPQ was the only significant UV-B-induced change in the photosynthesis parameters
suggesting a slightly increased energy flow to photochemistry
This was accompanied by higher concentrations of chlorophyll and flavonols
adding UV-B to red PAR growth light boosted photosynthesis of cucumber plants compared with the corresponding red PAR control
and Rdark indicated increased photosynthesis
this was not due to improved photochemistry (no increase in α)
but rather due to a positive effect on the biochemical processes regulating CO2 assimilation
supplementary UV-B had no negative effect on Fv/Fm and did not induce any additional stress to the photosynthetic machinery of red-light-grown plants
no changes in epidermal pigment content (chlorophyll
and anthocyanin) were observed when supplementary UV-B was added to a red PAR growth light
The positive effects on photosynthesis may explain the lack of growth inhibition caused by UV-B in a background of red growth light
it seems that such another stress (in this case photoinhibition) has to be of a certain magnitude for a plant to benefit from the UV-B treatment
the effect of UV-B mitigating a second stress
follows a gradient from no beneficial effect at all in non-stressed leaves to a beneficial effect in already light stressed leaves
we show that different monochromatic light backgrounds exert different responses in growth and physiology in cucumber
enabled normal photosynthetic functioning of leaves of cucumber plants without compromising biomass accumulation
Despite being exposed to the same light level
plants grown in green light showed low light acclimation of photosynthesis
but because of the changed canopy architecture with larger and thinner leaves these plants had the highest total biomass production
the low light acclimation was more pronounced and accompanied by light stress symptoms that reduced Fv/Fm and also led to reduced growth
Our data confirmed our second hypothesis that cucumber responses to UV-B are highly dependent of the spectrum of monochromatic growth light
Supplementary UV-B radiation decreased plant growth and development in plants grown under blue
Although the results suggest dysfunctional photosynthesis in plants grown under red light
UV-B boosted some photosynthetic parameters
actually increasing the potential carbon gain
UV-B and red light could act synergistically on priming the plant antioxidant capacity and diminish negative effects of photoinhibition
a more in-depth study of the metabolic and molecular pathways and antioxidants triggered by the treatments is required to fully explain our findings
The findings presented here could have a positive impact on horticultural settings
By using the right monochromatic light in early stages of cucumber production
plant development may be accelerated and thus decreasing overall production time
The original contributions presented in the study are included in the article/Supplementary Material
Further inquiries can be directed to the corresponding author/s
CP performed the experiment and most of the analysis
LM assisted with analysis and worked on the manuscript
ER helped analyzing data and edited the manuscript
C-OO worked with editing of the manuscript
ÅS prepared spectral figures and edited the manuscript
All authors contributed to the article and approved the submitted version
The project was funded by GUDP (Danish Ministry of Food, Agriculture and Fisheries) for the project Dynamic light, Interreg North Sea project SMARTGREEN and research center iFood. This project was also funded by research grants from the Knowledge Foundation (http://kks.se; grant #20130164), and the Swedish Research Council Formas (http://formas.se/en; grant #942-2015-516)
The project was also supported by the Faculty for Business
Science and Technology at Örebro University and by Örebro University Vice Chancellor’s strategic research programme on ‘Food and Health’
project was covered by the Research School for Science and Technology and iFood (Aarhus University Centre for Innovative Food Research)
Irina Kalbina for the technical assistance and guidance
We also thank Nikolaj Bjerring Jensen and Dr
Rong Zhou for the helpful discussion and critical evaluation of the manuscript
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpls.2020.610011/full#supplementary-material
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maximum photochemical efficiency of PSII; Fq ′ /Fm ′
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The blue-light receptor cryptochrome 1 shows functional dependence on phytochrome A or phytochrome B in Arabidopsis thaliana
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Copyright © 2021 Palma, Castro-Alves, Morales, Rosenqvist, Ottosen and Strid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
*Correspondence: Carl-Otto Ottosen, Y29vQGZvb2QuYXUuZGs=
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Volume 10 - 2019 | https://doi.org/10.3389/fpls.2019.00391
This article is part of the Research TopicPrimary Metabolism in FruitsView all 31 articles
The monocot banana fruit is one of the most important crops worldwide
the harvest of commercial bananas usually occurs when the fruit is physiologically mature but unripe
The universal treatment of green bananas with ethylene or ethylene-releasing compounds in order to accelerate and standardize the ripening of a bunch of bananas mimics natural maturation after increasing the exogenous production of ethylene
The trigger of autocatalytic ethylene production regulated by a dual positive feedback loop circuit derived from a NAC gene and three MADS genes results in metabolic processes that induce changes in the primary metabolism of bananas
These changes include pulp softening and sweetening which are sensorial attributes that determine banana postharvest quality
bananas accumulate large amounts of starch (between 15 and 35% w/w of their fresh weight
Pulp softening and sweetening during banana ripening are attributed not only to changes in the activities of cell wall hydrolases but also to starch-to-sugar metabolism
starch granule erosion and disassembling are key events that lead bananas to reach their optimal postharvest quality
The knowledge of the mechanisms that regulate sugar primary metabolism during banana ripening is fundamental to reduce postharvest losses and improve final product quality
Recent studies have shown that ethylene-mediated regulation of starch-degrading enzymes at transcriptional and translational levels is crucial for sugar metabolism in banana ripening
the crosstalk between ethylene and other hormones including indole-3-acetic acid and abscisic acid also influences primary sugar metabolism
we will describe the state-of-the-art sugar primary metabolism in bananas and discuss the recent findings that shed light on the understanding of the molecular mechanisms involved in the regulation of this metabolism during fruit ripening
there is an indication that the pattern of starch accumulation and degradation is highly correlated with the banana specie
Starch consists of linear amylose and highly branched amylopectin in the proportion 20:80. Amylose is formed by linear α-D-(1,4)-glucose units, whereas amylopectin consists of several short chains of α-D-(1,4)-glucose units interconnected by α-D-(1-6)-glucose units making up to 6% of the bonds in the molecule (Buléon et al., 1998; Hoover, 2001; BeMiller, 2019)
These two macromolecules are arranged in the form of granules with a well-organized internal structure
alternating between semi-crystalline and amorphous layers
The granules of banana starch are highly resistant to enzymatic hydrolysis
and they appear to undergo the natural process of degradation by enzymatic corrosion of the surface
the abovementioned studies show no evidence of porous structures at the granule surface
which would facilitate the access of hydrolases during ripening
Figure 1. Scanning electron microscopy (SEM) images of starch from unripe bananas. Starch granules isolated from unripe (A) Terra (plantain), (B) magnification of image, (C) Thap Maeo (banana), and (D) magnification of image, treated with porcine α-amylase (24 h; 37°C; 3 U/mg of starch). Images produced by SEM were acquired by the authors following the protocol described by Peroni-Okita et al. (2015)
Starch-to-sucrose metabolism has been extensively studied in model systems in the context of energy sources for plant growth and development
including Arabidopsis leaves (transitory starch) and the endosperm of germinating cereal seeds (storage starch)
Both metabolism and energy supply in photosynthetic tissues clearly differ from the equivalent processes in heterotrophic tissues
The starch breakdown in fleshy fruits such as bananas is less understood
Starch-to-sucrose metabolism in model systems and banana pulp
Main enzymes responsible for starch degradation in (A) Arabidopsis leaves
it is likely that GWD- and PWD-induced phosphorylation of banana starch favors granule hydration and phase transition from the crystalline state to the soluble state
In Arabidopsis leaves, the neutral and phosphorylated glucans released from the granule surface undergo a complex net of enzymatic reactions. Starch-dephosphorylating enzymes prevent phosphate groups from obstructing the action of other enzymes, while starch-debranching enzymes from both the isoamylase-like protein 3 sub-family (DBE\ISA3, EC 3.2.1.68) and the limit dextrinase family (DBE\PUL, EC 3.2.1.142) hydrolyze side chains at the C6 position (Streb et al., 2012)
and 10 MaBAM transcripts were observed at various stages of development and ripening in bananas of cv
and MaBAM3c showed high levels of relative expression after climacteric in both cultivars
Recently, an extensive study (Xiao et al., 2018) has found 38 genes associated with starch metabolism in bananas including three GWD
17 presented high transcript accumulation in ethylene-treated fruits (MaGWD1
The same pattern was also observed at the climacteric of naturally ripening bananas and in fruits treated with 1-MCP
the fruits treated with 1-MCP were long delayed in relation to those allowed to ripen naturally
as ripening took place only after the increase of endogenous ethylene synthesis
the authors have identified 18 proteins related to starch degradation in protein extracts isolated from starch granules of unripe and ripe bananas
and MaISA3 had higher levels in the extracts isolated from ripe than those from unripe fruits
A similar trend was observed in their transcript levels
as confirmed for the MaGWD1 protein by Western blotting using an anti-GWD1 antibody
MaGWD1 accumulation was accelerated in ethylene-treated bananas and delayed after 1-MCP treatment
Although the evidence points to a significant role for ethylene in the regulation of starch mobilization in bananas, there is a lack of systematic analysis of ethylene response elements in the promoter regions of genes associated with starch metabolism in the Musa genome. Miao et al. (2017) have identified response elements to diverse hormonal classes in the upstream regions of 16 MaBAM genes
which was highly expressed in the fruit after the climacteric peak
showed a single element of ethylene response (ERE) in the promoter region
This gene also had elements of response to auxin
and methyl jasmonate in the promoter region
suggesting a multi-hormonal regulation of expression
Ethylene-induced regulation of starch degradation
(A) A dual feedback loop of MADS-box sequences (MaMADS) and no apical meristem (NAM)
Arabidopsis transcription activation factor 1/2 (ATAF)
and cup-shaped cotyledon (CUC) (NAC) transcription factors appear to regulate ethylene responses in bananas
This results in the (B) induction of several genes related to starch degradation during fruit ripening including a glucan
six α- and β-amylases (MaAMY3
and a plastidic glucose translocator (MapGlcT2-2)
Treatment with gibberellic acid also promoted a delay on starch degradation in bananas (Rossetto et al., 2003), although the mechanism is apparently not the same as for auxin. Studies with other hormones such as abscisic acid and methyl jasmonate have influenced banana ripening in other aspects, such as cell wall metabolism (Lohani et al., 2004) and carotenoid synthesis (Kaur et al., 2017)
more research needs to be carried out to fully understand the cross talk of these plant hormones in starch-to-sucrose metabolism during banana ripening
The circuit was derived from a no apical meristem (NAM)
and cup-shaped cotyledon (CUC) (NAC) TF and the three MADS transcription factors described above (MaMADS 1
The effects of hormones and TF on the starch-to-sugar metabolism in bananas continue to be a field for further research
Further studies may add more layers of complexity to the understanding of the regulation of this pivotal metabolism in the physiology of the fruit
in addition to enabling the enhancement of its commercial quality
All datasets generated for this study are included in the manuscript
All authors equally collected literature data
wrote the manuscript and revised the article
The authors acknowledge the São Paulo Research Foundation (FAPESP; Grants (FAPESP; Grant #2013/07914-8)
VC-A received a fellowship from the Coordination of Improvement of Higher Education Personnel (CAPES; Finance Code 001)
JRON has a Fellowship in Research Productivity 1D and EP has a Fellowship in Research Productivity 2 both granted by the National Council for Scientific and Technological Development (CNPq; Grant #310511/2018-6 and #311773/2016-8
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Received: 05 February 2019; Accepted: 14 March 2019; Published: 02 April 2019
Copyright © 2019 Cordenunsi-Lysenko, Nascimento, Castro-Alves, Purgatto, Fabi and Peroni-Okyta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
* Correspondence: Beatriz Rosana Cordenunsi-Lysenko, aG9qYWtAdXNwLmJy
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Volume 8 - 2023 | https://doi.org/10.3389/fcomm.2023.1217684
The focus of this study is to holistically analyse the influence of social media influencers' content on young people's lives in Ireland
this study aimed to answer the following research question: Who are the five preferred influencers that this young sample follows and what are their motives for following them
this study analyzed two free-answer questions that were part of a longer questionnaire via thematic analysis using NVivo
This study's sample population comprised 81 participants between 16 and 26 years old
part of the Generation Z cohort and living in Ireland
The results of the analysis indicated five main motives that make this young sample follow their preferred social media influencers
the findings in this study confirm that the sample is susceptible to being influenced by SMIs in different contexts
three drivers play a crucial role consist of parasocial relationship
the insights discovered in this research can provide essential information to marketers to support the development of more effective marketing communication strategies
This cohort is therefore an ideal sample group for this research
as they are actively online and tend to follow and interact with SMIs
Ireland was chosen as an accessible location for data collection and research
Additionally, the Digital News Report Ireland 2020, a study for the Reuters Institute for the Study of Journalism at Oxford University, found that Gen Z in Ireland is also increasingly using social media as their primary source for news consumption, growing by 3% points over 5 years (Kirk et al., 2020) with smartphones being used by 71% of Gen Zers as their primary device for accessing news, an increase of 18% points over 5 years (Kirk et al., 2020)
The literature available about SMIs and their impact on young people is limited, even more so regarding the influence of SMIs on Generation Z in Ireland. Borau-Boira et al. (2022) state that SMI is a relatively new topic of academic research; there are still few studies exploring how followers perceive the figure of the influencer
which is crucial to design marketing strategies
The purpose of the present study is to holistically analyse the influence of social media influencer content on young peoples' lives
This objective can be summarized as the following question: Who are the five preferred influencers that this young sample follows and what are their motives for following them
This article highlights responses to this question through a thematic analysis
This research was conducted in Ireland with participants living in Ireland
and they pertain to the Generation Z cohort aged 16 to 26
two educational institutions were contacted
written consent was obtained from subjects over 18 years old and from subjects and their parents or legal guardians when under 18 years old
Sample demographics (Figure 1) of the total population (N = 81) are as follows: N = 50 female, N = 31 male; N = 56 ages from 16 to 19 years old, N = 25 ages from 20 to 26 years old; N = 52 are enrolled in a secondary school and N = 29 are enrolled in a private higher education institution (Jackson and Bazeley, 2019; NVivo, 2022)
All participants lived in Ireland at the time of study and pertained to the Generation Z cohort
Demographic information of the sample population
Two free-answer questions of the SUSIS questionnaire were designed to get as much insights as possible from the participants' responses
These questions are: Q5-Please indicate your five most favorite influencers and in which social media channel you follow them; and Q6-Please indicate five main motives that make you follow your favorite influencers
The responses to these questions directly correlate to the research question of the present study: Who are the five preferred influencers that this young sample follows
and what are their motives for following them
Data was collected in 2022 at two educational institutions in Ireland: a secondary school and a private higher education institution
The questionnaire informed the participants about the topic studied
their right to withdraw from the study at any time
the researcher's contact information and that participants must be living in Ireland and use social media to participate
participants were asked for consent to complete the first section of the questionnaire
The participants' views were clear in their answers
writing between one to three lines of text
All text was transcribed from the paper-based questionnaire outlining the 5 favorite influencers that this young sample follows
the channels where they follow them and the motives to be following them
Not all participants filled all blanks or linked the influencers to the specific motives
All Word files were converted to PDF and stored in NVivo
Example of preliminary notes taken during phase 1
“Students have been using the word “relatable” very often”
“There is a great diversity of influencers
and it might be difficult to find a pattern”
“Participants always refer to celebrities and singers as influencers”
“Participants were not assigning the influencers to the motives (Q5 to Q6)
they were generalising the motives”
“Participants tend to be motivated and inspired by their influencers”
As some participants did not fill in all blanks
according to their interests and preferences
Some participants might not have five favorite influencers or five main motives to follow these influencers
thinking mainly about answering the RQ and contribute to the research purpose with influencers
channels and motives receiving their own sets of nodes from 1 to 5
indicating descriptions and numbers of responses and references
NVivo was used to generate graphs for comparison and interpretation of the coding process, such as the number of cases coded by age (Graph 1) or by sex (Graph 2). Cases represent units of analysis (Jackson and Bazeley, 2019)
Graph 1. Codes by age, elaborated by the author using NVivo (2022)
Graph 2. Codes by sex, elaborated by the author using NVivo (2022)
The highest cases coded were counted in the ages 16 to 17
The most cases coded appear in the influencer and motive nodes as these spaces in the questionnaire required more effort compared to channels
After all relevant data was coded, patterns and relationships were identified and a list of themes related to the RQ and research objective was created. A theme is a broader category containing multiple codes that appear to be related to each other and indicate ideas that are generally important to the research question (Saunders et al., 2019)
Word similarity was also analyzed using NVivo at a code level and visualized by clustering (Graph 3)
The “Channels” element has more word similarities
The “Motives” element can generate patterns; however
the “Influencers” nodes show a diversity of words
indicating that generating patterns in this regard will be difficult
Graph 3. Items Clustered by Word Similarity, elaborated by the author using NVivo (2022)
The influencer and channel codes were analyzed first to identify patterns and relationships
As the RQ involves five preferred influencers for this young sample population
patterns were created with a ranking scale from 1 to 5
indicating the first to fifth most preferred influencers
channels and created themes were then selected based on this ranking scale
Nodes were then created in NVivo using the theme names for storage
Table 2. Word frequency analysis by themes/nodes, elaborated by the author using NVivo (2022)
This word count ranking confirms the clustering data from Graph 3
often ranging from 2 to 7 duplicate citations
in which frequency counts were much higher for Instagram
Motive codes were then analyzed, storing the patterns and relationships into new theme nodes using NVivo. Themes were created based on participant responses and experimenter interpretation of these data, taking the RQ into consideration to identify patterns and relationships. Figure 2 below shows an example of theme nodes in NVivo and their connection to codes
This analytical step goes beyond outlining the motives
additionally contrasting and correlating participant responses with theoretical interpretation
Figure 2. Codes and Themes for Motives, elaborated by the author via NVivo (2022)
green circles represent themes and yellow circles represent sub-themes
I engaged in a comprehensive process that began with an examination of motive codes
focusing on identifying patterns and relationships to create new thematic nodes within NVivo
depicted visually with colored circles for codes
went beyond merely outlining motives and involved a careful interpretation of participant responses and alignment with the theory
Themes were generated during a third phase
followed by an exhaustive fourth phase where I performed a recursive review of candidate topics
This meticulous review led to the elimination of themes that did not fit my analysis and culminated in the creation of a final thematic map that significantly contributed to answering the research question and achieving the objectives of the study
The central theme identified based on the analysis is the “demonstration of some degree of being influenced by SMIs,” since many quotes demonstrate a degree of influence in various ways
Other behavioral themes were generated based on an analysis of the participants' responses and related to the theory covered in this research
These themes are “showing some degree of parasocial relationship,” “showing some degree of trust” and “showing some degree of relatability.” Identifying themes related to these theories provides an insightful answer to the RQ
the last themes created were the main motives to be influenced by SMIs since the influence was evident through their responses
linkage to the theory and connection among themes were considered rather than ranking by frequency of a code
Such themes concerning motives are: “seeking for entertainment,” “following them because their content is interesting,” “following them because of product/brand recommendations,” “searching for advice
tips and learning” and “interested in their lifestyle and/or demonstrating interest in mental health
wellbeing and positive thoughts.” Sub-themes were identified based on occurrences linked to the main themes: “influenced by some sense of social causes or social justice,” “searching for news
political opinion and general information,” “showing some degree of care for appearance
body image and body satisfaction” and “searching for content related to sports
gym and fitness.” These sub-themes are motives by individuals to make them following influencers
some themes were consolidated without the need to remove or modify any themes
Finalized thematic map demonstrating themes
The themes and sub-themes, outlining the main excerpts from the data in a quotation format, were documented with an illustrative analysis for each theme and sub-theme (Appendix 1). Themes and sub-themes related to channels and influencers were quantitatively ranked and fully and deeply analyzed in the above sections and are therefore not included in this Appendix
The data excerpt table links themes and sub-themes
additionally including an interpretation of participants' views and an explanation as to the ranking of the motives
The purpose of the present study was to holistically analyse the influence of social media influencer (SMI) content on young people's lives
this study focuses on the following research question: Who are the five preferred influencers that this young sample follows and what are their motives for following them
This is since understanding motives for following SMIs also led to a better understanding of the influence of SMI content in their lives
dynamism of posts (57.9%) and interaction with audiences (61.7%)
Linking these factors with the research data
a parasocial relationship could be inferred between the sample population and their listed influencers
Some degree of intimacy from different perspectives
From a marketing perspective, parasocial relationships can lead to trust, thereby leading to increased levels of purchase intentions and brand evaluations, mainly when the SMI content contains advertising disclosures (Breves et al., 2021)
there is a certain degree of trust related to participant interaction with SMI content
The sample trust their influencers when searching for products and brand recommendations
which can be explained through a high level of parasocial relationship
the sample shows some sense of relatability to their SMIs
sharing common characteristics and personality traits
This might be another factor that strengthens the relationship between followers and SMIs
as they perceive their own characteristics and personality in their influencers
Consolidated ranking of the 5 Main Influencers by frequency
These influencers can be inferred to influence this sample more than other SMIs as they were cited more frequently. These influencers, a brief description and the type of content they post, their preferred social media platform and number of followers/subscribers can be found in Appendix 2
These data can be useful to improve marketing research as well as to enhance the quality of marketing communication
five main motives and some sub-themes were documented
This theme is connected to parasocial relationships and the next main motive
the second main motive was “Following them because their content is interesting,” as indicated by responses that clearly outlined interest in SMI content
While interest in SMI content can make a given person search for and follow the influencer
this varies and depends on each person's interests and needs
This theme is linked to the theme of trust
since the factors that cause participants to show interest are what might lead them to trust the influencers and their content
This study shows that SMIs indeed hold an important role in influencing young people to follow brands and buy products and are therefore key players in marketing strategies and should be taken into consideration to enhance the effectiveness of strategies
particularly in terms of digital marketing and social media marketing
Finally, the last motive was built based on participant response patterns (Appendix 1): “Interested in their lifestyle and/or demonstrating interest in mental health
wellbeing and positive thoughts.” This theme is linked to the theme of relatability and two sub-themes: “Showing some degree of care for appearance
gym and fitness.” This theme and the two sub-themes align with much of the principal content of the five main influencers
This demonstrates interest in the lifestyle of SMIs
this theme encompasses care for appearance and seeking advice in this regard
through this holistic analysis the sample population in this study was found to be susceptible to being influenced by SMIs in several different contexts
The main drivers that generated this influence were parasocial relationship
Different results can stem from such influence
interest in the content produced by SMIs and product/brand recommendations
From a marketing perspective and the participant responses
it is evident that SMIs have an important and influential role in marketing communication strategies
specifically regarding product and brand recommendations
the data analysis of a young sample population reveals a complex relationship between social media influencers (SMIs) and their followers
The susceptibility of these young individuals to be influenced by SMIs is intricately linked to three main themes: parasocial relationship
These participants seem to view their favorite influencers as friends
and extensive knowledge about SMIs and their content
fostered through intimate insights into influencers' lives
lays a foundation of trust that impacts participants' purchase intentions and brand evaluations
This trust is further emphasized when the SMIs' content contains advertising disclosures
with their effectiveness in engaging the audience hinging on their communicative skills
the influence of SMIs becomes a central theme
underpinned by the interaction of parasocial relationships
shaping marketing strategies and enhancing the understanding of Generation Z's digital engagement
and TikTok to be the primary platforms for engagement
focusing marketing strategies on these platforms could yield significant dividends
future research could also explore the ethical implications of such influence
especially in the context of susceptibility to misinformation
This might include regulations on the disclosure of paid partnerships and the vetting of information for accuracy when SMIs discuss topics like news or health
this study holds meaningful implications across various sectors
Managers can use the insights to refine their marketing strategies
academics can build upon the foundation laid by this research
and society at large needs to consider the regulatory and ethical frameworks that can harness this influencer power for the greater good
The research objective of this paper was attained
which aimed to provide insights into the factors that lead Generation Z to be influenced by social media influencers (SMIs)
The thematic analysis brought a holistic overview of this matter using participant responses and outlined the main influencers
their main channels and the motives for following them
The thematic map from the analysis can be used for
This research offers specific evidence for the influence of SMIs on young people's lives and is in line with previously published findings in the area
expanding it by providing a more focused point of view
Since motives to follow influencers can differ by age
this provides specific insights into Generation Z youth in Ireland
Previous studies as well as the current manuscript show important elements related to being influenced by SMIs in different age groups
The findings from this study can be useful for marketers to understand the importance of SMIs within marketing communication strategies
as well as to studies from the field of social sciences that aim to explore the influence of SMIs from both positive and negative perspectives
This research does not show direct evidence of harmful content promoted by SMIs
with the possible exception that a few influencers cited by participants might have some degree of aggressive gaming content related to war scenes and/or weapons
the intent of participants to seek information related to news and political opinion may also be a concern
as the information provided may not always be accurate
thereby drastically increasing the spread of fake news as these influencers can reach millions of subscribers
the attachment to other information provided by SMIs
Acknowledging the limitations of this study is essential to guide future research and ensure a more comprehensive understanding of the issues under investigation
The primary limitations encountered in this research pertain to the sample size and access to the sample population
both of which may have an impact on the breadth and depth of the findings
The sample size in this study was relatively limited
which may curtail the generalizability of our findings
Given that larger sample sizes have the potential to uncover a wider range of themes and subthemes
the current study's conclusions may not fully capture the richness and complexity of the phenomena under investigation
It is thus recommended that future research in this area consider using a more substantial sample size
A larger sample would allow for a more comprehensive exploration of the themes and subthemes pertinent to this area of study
thereby providing more robust and reliable data
Access to the sample population was also a significant constraint in this study
The utilization of a paper-based questionnaire distributed face-to-face inherently restricted the population that could be reached
limiting the diversity and range of participants
as those who are more accessible or willing to participate may not be representative of the broader population of interest
It is suggested that future studies could adopt more inclusive and wide-reaching data collection methods
Leveraging digital platforms for data collection
could facilitate wider access to potential respondents
This would ultimately enhance the representativeness and validity of the findings
an online questionnaire may more easily provide results from a larger sample size
Further analyses should also more deeply investigate the motives that make young people follow their influencers from a cross-cultural perspective
making the results applicable to different counties and cultures
further study can investigate and define different types of influence and content
such as contrasting positive and negative content
Although the findings provide important insights
it is crucial to reflect critically on some aspects of the research
such as explicitly investigating the effect of marketing advertisements promoted by SMIs on young people's lives
This research clearly highlighted five main factors influencing young people in Ireland to follow their influencers
this study shows evidence that their favorite SMIs hold influence over this sample in different contexts
Some degree of parasocial relationship and trust are identified through the analysis as drivers of this influence
marketers can encourage the presence of the factors discovered here to enhance the online presence of SMIs within marketing communication strategies focused on specific target audiences
such as the Generation Z cohort studied here
Marketers might also use this study as a foundation for designing new frameworks and strategies they wish to impose on customers who follow influencers to increase the leverage of a marketing communication strategy by better understanding target audiences and the macroenvironment
this manuscript makes a noteworthy contribution to the field by providing a comprehensive analysis of the influence exerted by social media influencers (SMIs) on the lives of Generation Z in Ireland
The research delves into the preferences and motives of this demographic in following specific influencers
thereby illuminating the contributing factors to this influence
The findings underscore parasocial relationships
and relatability as the principal drivers of SMI influence on this young population
The identified susceptibility to influencer impact is widespread
The research elucidates the paramount role of SMIs in marketing communication strategies
especially in the domain of product and brand endorsements
The insights garnered can be leveraged to bolster the effectiveness of these marketing approaches
thus enhancing their ability to resonate with and influence Generation Z
this study contributes to the understanding of how young people communicates with their influencers and the potential impact behind this phenomenon
this study strengthens the existing body of literature by augmenting it with a more refined perspective on the studied population
Despite the limitations concerning sample size and population access
the findings proffer a deeper comprehension of the sway of SMIs over young people's lives
The findings act as a stepping stone for future research
paving the way for explorations into cross-cultural perspectives
and the impact of SMI-promoted marketing advertisements
this study goes beyond answering its central research question about the identity and appeal of five preferred influencers for a young sample
It embarks on a thematic analysis to illuminate the underlying motives that make these young individuals follow their chosen social media influencers
With the inclusion of 81 Generation Z participants residing in Ireland
the study findings confirm that these young people are susceptible to the influence of SMIs across various contexts
this research offers valuable insights that inform marketing strategy and contribute to the academic discourse on the influence of social media influencers on the youth
It provides a crucial starting point for additional investigations and serves as a vital reference for further scholarly inquiries and marketing practices alike
The original contributions presented in the study are included in the article/Supplementary material
further inquiries can be directed to the corresponding author
The studies involving humans were approved by TU Dublin Blanchardstown Campus Ethics Committee
Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin
and roles and writing—original draft: CA
This research was partially funded by: Technological University Dublin (2020/21)
I would like to thank gratefully the guidance of TU Dublin's faculty in the collection of data
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcomm.2023.1217684/full#supplementary-material
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Citation: Alves de Castro C (2023) Thematic analysis in social media influencers: who are they following and why
Received: 05 May 2023; Accepted: 29 August 2023; Published: 15 September 2023
Copyright © 2023 Alves de Castro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
*Correspondence: Charles Alves de Castro, Y2hhcmxlc0BpY2QuaWU=
CUNY Home
The City University of New York
More about Carlos dos Santos, Jr.
2016 | Kingsborough Community College
is a noted Brazilian performer and choreographer
who performed as a principal dancer with major Brazilian dance companies such as
Dos Santos has performed with Complexions Contemporary Ballet
His choreographic credits include works for Colorado Ballet
He has created many projects with Dance Brasil
including his latest collaboration with award-winning composer
colleges and universities throughout the U.S
and abroad and has served as a jury member and resident choreographer of Youth America Grand Prix international student ballet competition since its inception
The CUNY Dance Initiative receives major support from the Howard Gilman Foundation and Mertz Gilmore Foundation
Additional support is provided by the SHS Foundation
Eleições para conselhos tutelares ocorreram no domingo (1) - © Tânia Rêgo/Agência Brasil
Although a final assessment of the elections for Brazil’s Child Protective Services has not yet been concluded
it can already be said there has been an increase in popular participation
but further work is needed to ensure more engagement and combat the conservative religious presence in these agencies
Partial data released by the Ministry of Human Rights and Citizenship (MDHC
indicates there was an increase of 25% in voter turnout
compared to what was recorded in the last elections
experts interviewed by Brasil de Fato state that this growth is still not enough and that communication about the election needs to be expanded to encourage the population to participate
Monitoring and valuing post-election work is also seen as crucial
a specialist in children's and youth rights
states that the current scenario favors conservative movements in these elections
Former national secretary for the Rights of Children and Adolescents and former president of the National Council for the Rights of Children and Adolescents (Conanda
Alves points out that the election must be treated as a priority by public authorities to involve the whole of society
“As this is an electoral process with optional and non-compulsory voting
neighborhood associations and parliamentarians are stronger
These sectors are the ones that participate the most and not exactly the common voter
especially because it was a very poorly publicized process.”
an estimated 1.6 million people voted in the capital cities
The number should increase with the consolidation of information from the more than 5,000 Brazilian municipalities that hold elections
Councilor Carlos Alberto de Souza Júnior
from the Municipal Council for the Rights of Children and Adolescents in the city of São Paulo
says that the rise in participation is important
“I always say that I would like 10% of the population to participate
We still face the challenge of making these elections known
We have further lost society's participation due to two elements: we need to improve communication channels to publicize the process
but we also need to create a method of publicizing candidates.”
a professor at the School of Social Service at the Federal University of Rio de Janeiro (UFRJ)
states that the increase in participation in the elections shows deeper engagement
but highlights that there are still consistent challenges
it is necessary to standardize the entire electoral process nationally
profile research and training of counselors
The predominance of elected candidates aligned with conservative agendas
even with an increase in the representation of the progressive democratic field
indicates there is still a path to be taken to achieve representation that is in full convergence with the precepts of the Child and Adolescent Statute (ECA
in Portuguese) and our Federal Constitution.”
She also mentions the need for valuing professionals through the creation of a minimum wage floor to attract qualified
the professor emphasizes that it is urgent to create conditions to expand the activities of the agency
A map of election results in the city of São Paulo
made by Paulo César de Oliveira and published by the Institute of Public and Social Cooperation
shows the presence of the conservative field in Child Protective Services.
58% are aligned with the field and 35% support the progressive agenda and the effective application of the ECA
Ariel de Castro Alves sees the influence of national political polarization in this scenario
particularly those that lost the national electoral process last year
It’s a kind of payback in light of last year’s presidential election and also in favor of the conservative agendas they defend.”
Carlos Alberto de Souza Junior states that overcoming the conservative agenda within Brazil’s Child Protective Services is the biggest challenge
“Conservatism within an agency like Brazil’s Child Protective Services completely undermines its effectiveness
regardless of who the child or adolescent is
Extreme conservatism protects rights in its own bubble.”
the elections amplified warnings made by the national network for the defense of children and youth about the influence of conservative religious groups and far-right parties on the agency
she identifies signs of resistance from the progressive field
citing as an example the platform The Election of the Year
an initiative that provided information about candidates committed to the Statute of Children and Adolescents
More than 2,500 applications were listed on the website
26 of the 106 candidates listed on the platform were elected
signaling a movement towards more progressive representation (…) These initiatives
together with the increase in popular participation
indicate the beginning of a collective effort to counterbalance the conservative influence and reaffirm democratic and progressive principles in Child Protective Services
But there is still a long way to go,” she concludes
the Ministry of Human Rights and Citizenship intends to publish a final report on the elections for Brazilian Child Protective Services
What is known in Brazil as “Conselhos Tutelares” are municipal bodies responsible for protecting and guaranteeing the rights of children and adolescents
They were created by the Child and Adolescent Statute (ECA
a Brazilian legislation that establishes the rights and duties of people under the age of 18
The main roles of Conselhos Tutelares are:
• Ensure the rights of children and adolescents: Its main goal is to ensure that the fundamental rights of these young people are respected and guaranteed
• Respond to cases of rights violation: When a situation of violation of the rights of a child or adolescent occurs
Child Protective Services must act to protect the victim and take the necessary measures to solve the problem
• Guiding families: It also guides families through risky situations or social vulnerability
offering support so that they can adequately care for their children
• Refer cases to the Public Prosecutor's Office: When a situation of violation of rights is serious and requires legal measures
Child Protective Services has the power to forward the case to the Public Prosecutor's Office
which can take the necessary legal measures
• Engage in protection networks: Child Protective Services are part of child and adolescent protection networks
to promote the protection of children's and teens’ rights
The agency is made up of counselors elected by the local community who play a fundamental role in promoting and defending the rights of children and adolescents
acting as one of the public services to contact in cases of violation of these rights
They perform their functions independently and autonomously
being an essential tool in ensuring compliance with the ECA at the municipal level
All original content produced and editorially authored by Brasil de Fato may be reproduced
provided it is not altered and proper credit is given
All original content produced and editorially authored by Brasil de Fato may be reproduced
Metrics details
Assessing the vector diversity and abundance provides information on the local malariogenic potential or risk of transmission
This study aimed to determine the Anopheles species composition
and distribution in areas with autochthonous and imported malaria cases in Roraima State
A longitudinal study was conducted from January 2017 to October 2018
sampling larvae and adult mosquitoes in three municipalities of Roraima State: Boa Vista
These areas have different risks of malaria importation
Four to six mosquito larval habitats were selected for larval sampling at each municipality
along with two additional sites for adult mosquito collection
All larval habitats were surveyed every two months using a standardized larval sampling methodology and MosqTent for adult mosquitoes
A total of 544 Anopheles larvae and 1488 adult mosquitoes were collected from the three municipalities studied
Although the species abundance differed between municipalities
were collected from all larval habitats studied while Anopheles darlingi were collected only from Boa Vista and São João da Baliza
Adults of 11 species of the genus Anopheles were collected
and the predominant species in Boa Vista was An
darlingi (85.6%) was the most predominant species followed by An
the most abundant species in Pacaraima was Anopheles braziliensis (62%)
the majority of anophelines exhibited greater extradomicile than peridomicile-biting preference
Anopheles darlingi was the only species found indoors
Variability in biting times was observed among species and municipalities
This study revealed the composition of anopheline species and habitats in Boa Vista
The species sampled differed in their behaviour with only An
Anopheles darlingi appeared to be the most important vector in São João da Baliza
although there were increasing reports of imported malaria
Understanding the diversity of vector species and their ecology is essential for designing effective vector control strategies for these municipalities
characterizing the vector species involved in local transmission in these border municipalities and their larval habitats is considered a priority
this study aimed to identify anopheline larval habitats and mosquito species distribution and behaviour in areas with imported (Boa Vista and Pacaraima) and autochthonous malaria (São João da Baliza)
The identification of potential larval habitats and the ecological conditions that determine the presence of Anopheles species competent to transmit Plasmodium is an important contribution for the control and elimination of malaria in Roraima
This information will allow for the assessment of potential local malaria vectors in each municipality and may explain differences in transmission patterns
The long-term goal is to direct vector control measures as part of integrated policies to reduce the region's malariogenic potential and mitigate
Map of Roraima State with highlights on rivers
and locations of the municipalities of Pacaraima—1
and surrounding vegetation in Boa Vista (A)
Adult mosquitoes were collected in January
comprising dry (November to April) and rainy (May to October) seasons
the collections were performed simultaneously at two sites
for three consecutive days at sunset from 18:00 to 21:00 and compared in the intradomicile
Sampling efforts throughout the studied period consisted of 480 h in each site: 144 h in the intradomicile (Nasci aspirator)
and 192 h in the extradomicile (96 h with MosqTent and 96 h with Shannon)
Species were morphologically identified using dichotomous keys for the Neotropical Anopheles species
triannulatus complexes were not identified in this study; these species are referred to as sensu lato
Daily and monthly rainfall data were obtained from the National Water Agency (Agência Nacional de Águas
Statistical analyses were performed using GraphPad InStat
Comparisons between mean temperature and pH were performed using the Wilcox test
To evaluate the association of environmental factors with the occurrence of species in larval habitats
univariate logistic models was used with species as the outcome
and debris) were used as independent variables
The associations between species and environmental variables were presented as odds ratios (ORs) and their 95% confidence intervals
Differences between the two non-reference categories were related to reference categories
Anopheles spp. larvae were found in all 15 permanent larval habitats in the studied municipalities: four sites in Boa Vista, six in Pacaraima, and five in São João da Baliza. Table 1 shows the main characteristics of each larval habitat and larvae of Anopheles spp
were found in all four types of water collection
Streams were widely distributed (66.6%) in the study area
the types of water collections were streams and lakes; in Pacaraima
26.7% of the habitats had a surface area of < 150 sq m
while 40% were > 150 < 300 sq m and 33.3% had a surface area greater than 300 sq m
The majority of the larval habitats in Boa Vista were located at a distance > 15 m from houses
larvae were found in both transparent (60%) and turbid (40%) water habitats
the water current was slow-moving (53.3%) or stagnant (26.7%)
and the temperature and pH were distinct in the habitats sampled
the larval habitats presented a lower water temperature (20.48 ± 1.0) than in Boa Vista (25.5 ± 3.2; p < 0.0001) and São João da Baliza (26.4 ± 0.95; p < 0.01)
and a higher pH (6.0 ± 0.75) when compared to Boa Vista (4.1 ± 1.15; p < 0.01)
This study further observed that 53.3 and 33.3% of the habitats were partially shaded and shaded
Half of the larval habitats in Pacaraima were shaded
while in Boa Vista and São João da Baliza the majority were partially shaded
one of which was in Pacaraima and the other in São João da Baliza
Marginal vegetation was present in all larval habitats
while emerging vegetation was present in 73.3%
were found in all water bodies except in one fishpond in São João da Baliza
A total of 544 Anopheles spp. specimens were obtained from 15 larval habitats, and the relative abundance of each larval species encountered is presented in Table 2
A total of 12 species were identified from 209 late-instar larvae (third and fourth stages)
335 Anopheles spp larvae were not identified at the species level and considered for statistical analysis
mainly because they were early instar larvae (first and second stages) or were damaged
Collections of the immature forms showed that An
and Anopheles peryassui were collected from larval habitats from all municipalities while An
Anopheles matogrossensis and Anopheles oswaldoi s.l
were only observed in Boa Vista and São João da Baliza
Anopheles evansae was present in Boa Vista and Pacaraima
Anopheles mediopunctatus and Anopheles argyritarsis only in Pacaraima and Chagasia bonneae and Anopheles strodei were only found in São João da Baliza
99 larvae of eight species were collected mainly from two larval habitats; An
darlingi (44.4%) was the most abundant species
only a few second stage Anopheles larvae were collected
The municipality of São João da Baliza presented the highest number of larvae collected (264) of nine species and An
darlingi was present in all five larval habitats
this species was present in only two larval habitats
Pacaraima showed a total of 148 larvae of seven species collected
were collected from a single larval habitat (5) in a fishpond
the water had a lower pH and higher water temperature
The univariate logistic models for the four most frequent Anopheles species are summarized in Table 3
Anopheles darlingi was more likely to occur in the stream larval habitat (OR = 6.85
darlingi had a higher chance of being captured in larval habitats with 150–300 sq m of surface area than those larger than 300 sq m (OR = 3.83
Anopheles darlingi was also less abundant in stagnant water (OR = 0.08
p < 0.01) than in moderate water currents
The logistic models also showed a higher chance of An
to be found in larval habitats > 300 sq m (OR = 0.13
p < 0.01) than those < 150–300 sq m (OR = 0.29
had a greater preference for aquatic habitats with transparent waters over turbid water (OR = 0.24
occurred in aquatic habitats with both transparent and turbid water
Habitats exposed to the sun were related to the occurrence of An
p < 0.01) in comparison to those partially shaded
darlingi showed a preference for partially shaded over full sun habitats (OR = 0.1
Anopheles darlingi was more frequently observed in the presence of roots
p < 0.01) than in the absence of debris
was less likely to occur in habitats with debris (OR = 0.08
A total of 1,488 female Anopheles from 11 species were collected from all three municipalities (Table 4)
Nine species were identified in Boa Vista and An
Among the seven species collected from São João da Baliza
darlingi (85.6%) was the most predominant species
Pacaraima showed lower vector density than the municipalities of Boa Vista
evansae were observed only in Boa Vista and An
the majority of anophelines exhibited greater extradomicile than peridomicile biting preferences
Anopheles darlingi was the only species found in the intradomicile
were more abundant in the extradomicile than in the peridomicile
braziliensis was captured in the peridomicile (33.8%)
and in the extradomicile by MosqTent (29%) and by the Shannon trap collection (37.1%)
The longitudinal study showed variation in the abundance of Anopheles species according to the period studied (Fig. 3). The collection each month represents the mean number of Anopheles captured in that month per collector per hour (4 h of capture for three consecutive days) for every two months in each locality.
Seasonal dynamics of the most abundant anopheline species in Boa Vista (A)
The rainy season in the state of Roraima occurs between April and September. Even so, in Boa Vista this was the period with the greatest abundance of Anopheles. In Pacaraima and São João da Baliza these species were more frequent in the driest months. In Boa Vista (Fig. 3A) An
had the highest density during the studied months
with the greatest frequency observed in April in the dry season
The month of July for both years (2017 and 2018) had the greatest rainfall
Anopheles darlingi was not abundant during the study months but showed a population increase in October at the end of the rainy season
darlingi was predominant throughout the year
and this species was more abundant in October
was also collected in every month but in lower numbers
Frequency by time of capture (from 12-h collections) of the main vectors collected in Boa Vista (A)
The human biting rate (HBR) was estimated for the most common species collected in each municipality using the following calculation: the total number of anophelines captured during the 4-h collection (16:00 to 21:00) divided by the total number of collection days and the number of collectors. The data are presented in Table 5
showed the highest rate in the extradomicile (10.8 bites per night) followed by 3.8 in the peridomicile
darlingi predominates with a low HBR in the peridomicile (0.3 bites) and in the extradomicile (0.8 bites)
HBR was low in both the peridomicile (0.26) and extradomicile (0.22) for An
darlingi presented higher HBR in the peridomicile (1.07) and in the extradomicile (1.64) than in Boa Vista while An
São João da Baliza was the only municipality where An
darlingi was collected in the intradomicile (three specimens at 19:00–20:00 and one at 20:00–21:00)
Entomological surveillance to identify the component members of these complexes are mandatory to update the geographic distribution
and its possible role as a regional vector of malaria parasites in Roraima
presented the highest density at the end of the rainy season
and was characterized as a less abundant population in interior regions than in riparian areas
peaked at the beginning of the rainy season and was more abundant in the interior
One of the control measures used in the malaria control programme in Roraima is indoor residual spraying
which may explain the exophilic behaviour of this species in the studied area
braziliensis may play some role in malaria transmission in Pacaraima when at high densities
This study showed a diversity of anopheline larvae species and habitats in Boa Vista
although there are increasing reports of imported malaria
Considering the behaviour of the vectors in Boa Vista
interventions such as intradomiciliary spraying will likely be insufficient to reduce malaria transmission
It can be speculated that the local vector assemblage in Boa Vista is sufficient to sustain the disease
and also provides a time buffer to mitigate the effects that imported cases would otherwise have if An
This circumstance offers an opportunity to reduce the effects of cross-border malaria via early diagnosis and timely treatment
environmental management of vector larval habitats and health education actions addressing individual and collective forms of prevention are indicated
The datasets during and/or analysed during the current study available from the corresponding author on reasonable request
Ministério da Saúde, Brasil. Datasus. Sivep Malária. Sistema Eletrônico do Serviço de Informações ao Cidadão (e-SIC). 2021 [Available from: https://esic.cgu.gov.br/sistema/site/index.aspx.Information
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We thank the technical team of the State Entomology Center for their support in the fieldwork and the mapping of larval habitats and the Secretary of Health of Roraima—General Coordination for Health Surveillance for fieldwork support
We also appreciate the reviewers for providing helpful comments and suggestions
The study received financial support from PAEF (IOC-023-FIO-18-2-47 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001
JOF was the recipient of a Research Productivity Fellowship from the National Council of Scientific and Technological Development (CNPq)
AAE was supported by a grant from the US National Institutes of Health
The funders had no role in the study design
Laboratório de Mosquitos Transmissores de Hematozoários
Maycon Sebastião Alberto Santos Neves & Teresa Fernandes Silva-do-Nascimento
Instituto Nacional de Infectologia Evandro Chagas
Department of Biology/Institute for Genomics and Evolutionary Medicine (iGEM)
and AAE conceived the idea and participated in the study design
and JL were responsible for the sample collection
and JS performed the experiments and analysed the data
corrected and approved the final manuscript
The authors declare that they have no competing interests
Dispersion graph of anopheline mosquitoes by mean intensity of rain
unless otherwise stated in a credit line to the data
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DOI: https://doi.org/10.1186/s12936-021-04033-1
Brazil - May 2022 - On the evening of Monday
on the occasion of the 180th anniversary of the founding of the Bahia State Council of Education (CEE)
the Salesians received the "CEE/180th Anniversary" Citation of Honor in recognition of their relevant contributions in the field of education
The ceremony was held at the "Castro Alves" theater in Salvador
and the Board of Directors of the Salesians of Bahia
The evening was entirely focused on education and included numerous artistic and cultural interventions
as well as a lecture given by Professor Aloízio Mercadante
Barreto expressed gratitude for this recognition
is the result of the tireless work of Salesians and lay people for a more humane and just education
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Getty ImagesA video of a naked Brazilian boy getting whipped with an electric cable is causing outrage in the country
Two security guards whipped the 17-year-old boy for allegedly stealing four bars of chocolate from a São Paulo supermarket, according to The Guardian.
The disturbing video shows the naked boy getting whipped and gagged with his hands tied.
“It is like a scene from centuries ago,” detective Pedro Luis de Souza told The Guardian
"They tied him up and whipped him until he promised to not do it again.”
According to The Guardian, the boy spoke with TV Globo
saying it was the third time he had been assaulted by the same two security guards after stealing from the supermarket
The supermarket has removed the security guards
“The company does not comply with any kind of illegality and will cooperate with the competent authorities involved in the investigation of the case in order to take the appropriate measures," the supermarket said in a statement
a counselor with the State Human Rights Council
told TV Globo that he is following the investigation and demanding the guards be held accountable for “barbaric and cruel acts of torture.”
“There is overwhelming evidence of a crime of torture by security guards," de Castro Alves told TV Globo
"Torture occurs when someone is subjected
to intense physical or mental suffering."
spoke with The Guardian and said the incident is connected to Brazil's history of slavery where Blacks were whipped daily.
"That guards filmed the torture showed how sure they were they would not get caught," Adami told The Guardian.
Seventy-five percent of Brazil’s 65,000 homicide victims in 2017 were Black or mixed race
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Renata Castro Alves, immigration attorney and founder of Castro Legal Group
says that there are both legal and personal frontiers to break
and that many aspects of being American are incorporated far ahead from ever becoming a naturalized citizen
she thinks nothing is more challenging than adopting American eating tastes and habits
“It is easy for foreigners to judge American lifestyle choices — having a sandwich for lunch, who else does that? — but the reality is, eating American food is the final frontier to really fitting the mold,” she tells Bustle. “I remember eating American foods
such sweet potato or green bean casseroles
and thinking that in my home country of Brazil
at a Christmas party my family attended with my Brazilian mom
I noticed how Americanized I had become when I reached to the Sweet Potato Casserole without hesitation.”
some people consider eating American foods to be the final frontier
12 women share what they first ate when they became American citizens
“I am an immigration attorney residing in Florida who was naturalized almost 10 years ago. Right after my naturalization interview, I had the most American meal of all — a Big Mac with a Coke and fries. [...] Nothing is more classic American fanfare than a burger with a Coke and fries.”
“I became an American citizen in 2007, more than a decade after immigrating to America. I celebrated this milestone by eating what, to me, was a quintessentially American meal — a steak burrito bowl from Chipotle with a side of guacamole and chips. Growing up in Kenya
[...] I would consider it authentic American
in the sense that this country has a way of Americanizing ethnic foods
I guess this is why they call America a melting pot: Many different cultures blended into one.”
“I got my citizenship about seven years ago in Los Angeles
I was lucky enough to share the special occasion with my sister
as we both got our citizenship on the same day
because it meant I had to give up my Ethiopian citizenship
The first meal I had after the ceremony was Ethiopian food
We went to Little Ethiopia in Los Angeles and treated ourselves to some delicious
You can take the girl out of her Ethiopian citizenship
but you can’t take Ethiopian food out of the girl
“I’m from Colombia and became an American citizen when I was 69
(I came to be with my son and granddaughter.) Afterwards
I went to Cracker Barrel with my granddaughter
but I felt a sense of accomplishment and like my family was proud of me
It was a big moment for my family back in Colombia and is the biggest accomplishment of my life.”
“I became a citizen alongside my mother in 2013
we went to Red Lobster — because it’s the pinnacle of American ‘high-end’ chain food — and indulged in all the buttery seafood
It was definitely a special moment between my mother and I since we shared in the special moment of going through the ceremony together and then decompressed together under nautical décor and dimmed lighting.”
I ate at a very nice restaurant and had seafood
My citizenship made me feel a huge sense of achievement because I could successfully start carving the life I wanted for my family in America.”
“My parents moved me from Colombia to the U.S
so I had a permanent resident card until I was 18
we drove to Atlanta in order for me to become a U.S
citizen and we ate at [...] a buffet-type place
which was a big treat for me at the time.”
I HAD to have an American hot dog with everything on it
I meant it — but had no idea there would be soooo many things on it — not just mustard
I think about it and try to go find an all-beef Chicago-style hot dog — with everything on it — wherever I am
It immediately reminds me that I’m happy and proud to be an American and the freedom that goes with it
I had seen it in American movies all the time
and I couldn’t wait to taste the real thing once I was in America
But I waited until I became a citizen for the big day
“I went on my lunch break and came right back to work
I scarfed down a sandwich and went back to work so I could keep providing for my family
Earning my citizenship was something I’d always dreamed of so
“My American college professor took me to my first dinner in the U.S.
where I ordered three entrees of Mexican food
(A typical plate is the size of your palm.) I hadn’t eaten for over 24 hours and was starving by the time we got to the restaurant
‘Are you sure you will be able to eat three entrees?’ my professor asked
three entrees would’ve been no problem with how hungry I was
so I thought all this food would be wasted
my professor explained that I could take all this food with me and finish it the next day.”