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Suscribe x MercoPress, en Español Montevideo, May 5th 2025 - 13:25 UTC The beach resort of Camboriú in the southern Brazilian State of Santa Catarina has been declared under emergency Thursday following heavy rains that flooded that place and others such as Florianópolis First responders have been working around the clock while State authorities also set up shelters as the need for improved drainage systems and flood prevention infrastructure has been highlighted Residents were also advised to exercise extreme caution in flood-prone areas Camboriú Mayor Juliana Pavan declared the emergency after more than 120 millimeters of rainfall were recorded in just a few hours flooding city streets and adjacent roads such as BR-101 Argentine tourists were reported to be arriving en masse for the second half of January as a convenient exchange rate advises against vacationing in their home country about 130 millimeters in the cities of Itajaí Camboriú and Balneário Camboriú More than half the volume expected for the entire month of January,” Santa Catarina Governor Jorginho Mello pointed out According to Camboriús Urban Mobility's Ricardo Pastrana lines were over 26 kilometers long in either direction passing through Porto Belo Pavan's measure triggered the Emergency Disaster Response Plan summoning volunteers to reinforce response actions and crowdfunding campaigns The City Council also announced the opening of three emergency shelters The Response and Action Coordination Group (GRAC) and teams from Civil Defense the Department of Public Works and Public Safety are working together in the area to ensure the safety of the population and tourists especially considering that these climatic phenomena increase the probability of landslides no weather model predicted Thursday's crisis characteristic of maritime circulation rains caught people in Itajaí and Camboriú by surprise Santa Catarina's experimental meteorological station Epagri/Ciram is not capable of detecting this type of weather phenomenon in time Epagri/Ciram's expert Gilsânia Cruz told local media that identifying this type of phenomenon depends on smaller-scale precision models in addition to meteorologists being able to handle new forecasting models Foul weather is expected to continue until at least Saturday Brazil's Civil Defense Department predicted heavy and persistent rains will continue to affect Bombinhas Mello had already made headlines Wednesday when he highlighted that the city of Pomerode known as the most German city in Brazil “stands out for the color of people's skin.” According to Brazil's Institute of Geography and Statistics (IBGE) The Governor's statement during the opening of the 40th Pomeranian festival was posted on the Santa Catarina State's website on audio and went viral for its alleged “racist” tint which could result in criminal charges against the State's Chief Executive and this accusation doesn't apply to me,” Mello insisted Commenting for this story is now closed.If you have a Facebook account, become a fan and comment on our Facebook Page there is no English translation for the word ‘hike.’ At least Home / Living there is no English translation for the word 'hike.' At least being a native speaker and an enthusiastic hiker This may be because many Brazilians do not view hiking as a leisure activity if there is a gorgeous beach on the other side of a mountain Brazilians will always find a way to get there and enjoy it This holiday season I experienced my first Brazilian hike a municipality in the southern state of Santa Catarina We were there to spend time with family and to enjoy the flawless beaches that line the coast My grandparents own a small condo just two blocks from one of the area's most easily accessible and popular beaches They've had the getaway for nearly a decade and the whole family has fallen in love with this beach no matter how crowded it gets around the holidays Praia de Palmas' popularity is growing rapidly Some might say too rapidly for the infrastructure that is currently in place who have been there since the town was first starting to take shape We spent several mornings on the bustling beach and although we were having a fantastic time taking in the sights and sounds when my cousins suggested a trip to a 'secret' beach hidden behind the green hills that surrounded Palmas My cousin Juliane told us there would be walking and a forest trail involved in this adventure to find the beach called Praia do Sissial but what she described sounded like a hike to me so Cody and I prepared with tennis shoes and whatever hike-appropriate gear we packed The drive to the trailhead was only around 3 miles south of Palmas and easy to find Once the car was maneuvered to fit neatly into the side of the hill The first part of the hike was a very steep and wide trail that appeared to have been originally intended for vehicles to pass through but has now been roped off This section of the hike was before hitting the tree line of the forest so it boasted some amazing views of the surrounding hills This was my favorite part on the way back to the car after our hike and I was grateful for having worn my tennis shoes We were all panting and sweating within the first five minutes of our journey imagine my surprise when a little boy carrying a folded chair happily strolled past us They were all carrying a multitude of beach essentials and wearing only flip-flops on their feet further illustrating the great lengths Brazilians will go to just to find a good beach I was still happy with my footwear decision the trail narrowed and the temperature cooled as the summer heat can be quite intense when not counterbalanced by a sea breeze I was enjoying the safari of flora and fauna butterflies and even a lizard as we made our way toward the beach We reached the beautiful and secluded beach quickly; from the moment we stepped out of our vehicle to the moment we set our feet in the sand of Sissial the beach is very similar to Palmas: white sand clear ocean and green hills curving in at each end to cradle this little slice of paradise the size and tranquillity gave it a more 'boutique' feel There were only a few other beachgoers there including the flip-flop family from earlier and we decided to set up camp near large boulders nestled on the north end of the beach they reminded me of a grown-up jungle gym and added another unique experience to our day at the beach We climbed on them and sat watching the waves roll in and out in between swims in the crystal-clear water there is absolutely no infrastructure on this beach making Praia do Sissial a beautiful reminder of our planet's natural beauty but also requiring that you pack everything you might need while spending time there When we began to feel the burning sun linger just a tad too long on our shoulders and our stomachs began to grumble for lunch There are several hidden beaches in Governador Celso Ramos and many trails winding through the hills to find them The trail to Praia do Sissial is a great place to start as it is just challenging enough to scratch that hiking itch but not so challenging that you can't carry some beach gear with you I intend on beach-hopping to some of the other hidden beaches in the area I also want to bring folding chairs and lunch to Praia do Sissial and spend the entire day enjoying this secluded paradise If you ever have the chance to visit Governador Celso Ramos The Gazette has been informing Iowans with in-depth local news coverage and insightful analysis for over 140 years independent journalism with a subscription today © 2025 The Gazette | All Rights Reserved Airbnb announced a global ban on parties and events at Airbnb listings with an occupancy cap of 16 people worldwide "This party ban applies to all future bookings on Airbnb and it will remain in effect indefinitely until further notice," according to a company statement provided by Airbnb spokesperson Ben Breit on Thursday Parties have been a problem for the short-term rental company for some time both before and during the coronavirus pandemic One party at a New Jersey Airbnb attracted more than 700 people More: Florida author captures biz-booming Black community Glenwood in new photo book the company removed its "event friendly" search filter and its "parties and events allowed" house rules from listings that had previously allowed them It also required guests to follow local COVID-19 public health laws This led to an effective patchwork ban on parties and events But as public health attitudes have shifted depending on COVID-19 rates Unauthorized parties were never technically been allowed on the platform with 73% of its listings already banning them as part of their house rules The company laid down stricter limits last year with a ban on "party houses" worldwide "listings that create persistent neighborhood nuisance." It's also done manual reviews of what it considers high-risk reservations and restricted the rental permissions for guests under the age of 25 as part of its effort to get house parties under control The company announced earlier this year that U.S guests under the age of 25 who have fewer than three positive reviews and any negative reviews would be restricted from booking entire homes in areas close to where they live they are still allowed to book "any type of listing outside their local area" in addition to private rooms and hotel rooms anywhere There many be an exception to the new more-than-16-people policy: "We are currently scoping a potential exception process for specialty and traditional hospitality venues (i.e boutique hotels)," per the company's statement "Guests will be informed about Airbnb’s party rules and informed that they may be legally pursued by Airbnb if they violate our policy This work is currently being operationalized and will be rolled out in the near future." Airbnb acknowledges that 16 people is no "magic number," saying that it will "continue to enforce our party rules against groups of any size and will be taking action both on guests and listings if we receive reports from neighbors," the statement concluded And given that the service largely runs on the honor system it's likely guests will still try to get away with whatever they can Airbnb on Wednesday filed preliminary paperwork for selling stock on Wall Street undaunted by a global pandemic that has taken some wind out of its home-sharing business This comes as the company continues to contend with the effects of the pandemic including an onslaught of refund complaints It also recently suspended home-rental service Domio from its platform following a damning report from The Information "An investigation shows (Domio) has engaged in efforts to flout local rental laws with misleading online identities and other questionable business practices," according to the outlet According to another statement from Breit: "We have indefinitely suspended all of Domio’s associated host accounts and listings as we expand our investigation into their activity dating back to 2016 We will not hesitate to take aggressive action to remove suspicious content from our platform and depending on the outcome of our investigation we will determine the appropriate long-term action to take against these accounts." The pandemic initially hurt demand for the 7 million properties listed by Airbnb Chesky has said that Airbnb's 2020 revenue will likely be less than half what the company booked last year The company funded operations with $2 billion in loans including a $1 billion investment from private equity firms Silver Lake and Sixth Street Partners But demand has rebounded some as some travelers see home rentals as safer than than crowded hotels the company said guests booked more than 1 million nights' worth of future business It was the first time that threshold had been reached since March 3 PET with 18F-FDG has been considered of limited value for detection of bladder cancer because of the urinary excretion of the tracer The purpose of this study was to investigate the role of PET/CT in the detection and restaging of bladder cancer using furosemide and oral hydration to remove the excreted 18F-FDG from the bladder Methods: Seventeen patients with bladder cancer (11 without cystectomy 6 with total cystectomy and urinary diversion) underwent 18F-FDG PET/CT from head to the upper thighs 60 min after the intravenous injection of 370 MBq of 18F-FDG Additional pelvic images were acquired 1 h after the intravenous injection of furosemide and oral hydration Results: PET/CT was able to detect bladder lesions in 6 of 11 patients who had not undergone cystectomy These images changed the PET/CT final reading in 7 patients: Recurrent bladder lesions were detected in 6 patients pelvic lymph node metastases in 2 patients This technique overcame the difficulties posed by the urinary excretion of 18F-FDG Hypermetabolic lesions could be easily detected by PET and precisely localized in the bladder wall Seven of 17 patients (41%) were upstaged only after delayed pelvic images Conclusion: Detection of locally recurrent or residual bladder tumors can be dramatically improved using 18F-FDG PET/CT with delayed images after a diuretic and oral hydration The limitation of 18F-FDG PET has been attributed to the urinary excretion of 18F-FDG The pooled activity in the urinary bladder makes the evaluation of bladder wall lesions difficult or even impossible The purpose of this study was to assess the usefulness of 18F-FDG PET/CT with delayed images after diuretic and oral hydration in the detection of local and regional recurrences of bladder cancer All patients with a known history of bladder cancer referred to our laboratory from June 2003 to December 2004 for whole-body 18F-FDG PET/CT were retrospectively included for analysis PET/CT scans were requested for restaging purposes as the patients did not have symptoms of recurrence and no abnormalities were detected in previous radiologic studies 2 females) underwent PET/CT with 18F-FDG from head to the upper thighs All patients had been previously submitted to primary tumor resection by transurethral resection or cystectomy Histopathology confirmed transitional cell carcinoma in all cases The time interval between the primary tumor resection and the PET/CT scan was at least 3 mo to minimize inflammatory reaction caused by the surgical procedure Patients were divided into 2 groups: those without cystectomy (11 patients) and those with total cystectomy and urinary diversion (6 patients) All patients underwent routine restaging studies such as serial cystoscopy or MRI after PET/CT Fourteen patients were submitted to a single PET/CT study and 3 patients were submitted to 3 consecutive studies 23 studies were available for interpretation Patients were instructed to fast for at least 4 h before the intravenous injection of 370 MBq (10 mCi) of 18F-FDG Blood glucose was measured before injection of the tracer to ensure glucose blood levels below 120 mg/dL patients were kept lying comfortably in a quiet No urinary bladder catheterization was performed and no diuretics were administered at this time Saline infusion (approximately 500 mL) was given before tracer injection Whole-body PET/CT images were acquired 1 h after radiotracer injection using a Biograph PET/CT scanner with bismuth germanate detectors (Siemens Medical Solutions USA CT images were acquired without breath-holding instructions The PET emission scan was obtained immediately after acquisition of the CT scan with an acquisition time of 5 min for each bed position starting from the pelvis and ending at the base of the skull An additional single bed position acquisition was always performed for the head PET image datasets were reconstructed iteratively using the CT data for attenuation correction and coregistered images were displayed on a workstation After obtaining the PET/CT acquisitions from head to the upper thighs the patients were injected with 20 mg of furosemide intravenously They also received oral hydration with 800–1,000 mL of water Patients were instructed to void frequently Additional pelvic images were acquired 1 h after the intravenous injection of furosemide PET/CT images before and after furosemide were compared with each other and their findings correlated with MRI All PET/CT images were interpreted by 2 experienced nuclear medicine physicians; a third nuclear medicine physician helped to interpret the study when a final consensus was needed all patients demonstrated high tracer activity in the urinary bladder after the standard PET/CT acquisition Delayed pelvic images after furosemide and oral hydration showed marked reduction of urinary bladder activity: Urine with a low concentration of 18F-FDG replaced urine with a high concentration of the tracer in the bladder as a result of the diuresis promoted by oral hydration and furosemide Bladder activity was reduced to background levels in all bladder-preserved patients PET/CT Findings Before and After Diuretic and Hydration and PET/CT pelvic images (from left to right) show high concentration of 18F-FDG in urinary bladder (B) Delayed pelvic images after intravenous furosemide and oral hydration show excellent tracer washout A marked hypermetabolic lesion (maximum standardized uptake value [SUVmax] = 9.0) is easily seen in posterior wall of bladder (arrow) Note mild bladder wall thickening in CT images Bladder lesions were not known before PET/CT Of the 6 patients with positive bladder findings 2 were confirmed by MRI and further cystoscopic biopsy The maximum standardized uptake values (SUVmax) ranged from 5.0 to 10.1 for all hypermetabolic bladder lesions Histopathologic grades were not available for all biopsy samples Only 1 of the 6 patients with PET/CT-positive finding was submitted to radical cystectomy after the PET/CT scan The pathologic study of this patient's bladder was concordant with the previous cystoscopic biopsy The remaining 5 patients were treated with bladder-preserving strategies None of the 5 patients with negative bladder PET/CT had positive findings in other diagnostic imaging studies This subgroup of patients and the patients with bladder diversions followed routine restaging protocols such as serial cystoscopies and MRI malignancy was completely ruled out and therefore bladder wall biopsies were not performed PET/CT false-positive results due to inflammatory reaction after cystoscopic biopsy or transurethral resection were not observed in the bladder wall The 3-mo time interval between the primary tumor resection and the PET/CT scan was enough to heal any possible inflammatory reaction and PET/CT images (from left to right) before furosemide (A) show a pelvic lymph node on left side (SUVmax = 17.0) Delayed pelvic images after intravenous furosemide and oral hydration show excellent tracer washout (B–D) It is possible to identify diffuse uptake in bladder wall (SUVmax = 10.0) (arrow) adjacent to pelvic lymph node (dotted arrow) Note that there is no bladder wall thickening in the CT images and PET/CT images (from left to right) before furosemide (A) are normal Delayed pelvic PET/CT images (B) after intravenous furosemide and oral hydration show hypermetabolic lesions in bladder wall and in prostate gland (arrows) that could not be identified before diuretic injection A 67-y-old male patient with bladder cancer after cystectomy and urinary diversion and PET/CT pelvic images (from left to right) show high concentration of 18F-FDG in neobladder (B) Delayed pelvic images after intravenous furosemide and oral hydration show mild tracer washout all images were iteratively reconstructed and no streak artifacts were observed in the early or delayed images Since the pioneering study of Harney et al. (8), a small number of studies have investigated the value of PET with 18F-FDG in bladder cancer. Kosuda et al. used retrograde saline irrigation of the urinary bladder to remove 18F-FDG radioactivity, but they were unable to reduce tracer activity to background levels and reported a 40% false-negative rate for detection of recurrent or residual tumor in the bladder (11) continuous bladder irrigation and immediate postvoid images are not effective in reducing intravesical activity because the kidneys keep filling the bladder with urine with high concentration of 18F-FDG catheters and postvoid images were not used because these techniques make the CT evaluation of the bladder walls more difficult A full bladder is required to avoid artifactual thickening of the walls and bladder catheterization and continuous irrigation are too invasive for routine use Most investigators have obtained poor results when injecting a diuretic shortly before image acquisition The increased diuresis at this time cannot dilute the urine because there is still a high concentration of 18F-FDG in the blood The optimal time to inject furosemide is key to obtaining a satisfactory urinary dilution Kamel et al. have recently shown the potential of PET images to detect abdominopelvic malignancies (including 12 bladder lesions) after furosemide and parenteral saline infusion (30) the present study is the first to evaluate the usefulness of delayed pelvic images after diuretic administration and oral hydration with 18F-FDG PET/CT in bladder cancer patients PET images alone were not compared with PET/CT or CT alone CT images could detect bladder wall thickening and ruled out known pitfalls such as bladder wall diverticulum and urinary leaks Focally increased 18F-FDG uptake in the pelvis revealed by delayed PET images alone after furosemide could be in the bladder wall or in lymph nodes close to the bladder as well PET/CT images were of great importance to precisely locate pelvic hypermetabolic lesions As a metabolic and anatomic diagnostic tool, PET/CT with 18F-FDG has the ability to overcome the limitations of stand-alone PET and conventional imaging modalities leading to changes in patient management (10). Our results show that delayed 18F-FDG PET/CT images after diuretic and oral hydration can detect hypermetabolic lesions in the bladder walls with high-quality images. Besides the improvement in the detection of bladder wall cancer, delayed pelvic images after furosemide and oral hydration also helped to detect 2 lymph nodes close to the bladder and 1 prostate invasion. These lesions would otherwise be missed. However, the small number of patients with such lesions does not allow more advanced conclusions. COPYRIGHT © 2007 by the Society of Nuclear Medicine, Inc. Thank you for your interest in spreading the word on Journal of Nuclear Medicine. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Winds of over 120 km/h were reported in the state of Santa Catarina The states of Rio Grande do Sul and Paraná were also badly affected The wild weather has also brought the threat of flooding Storm surge has prompted warnings for coastal flooding in Santa Catarina river levels are above flood stage in some areas of after the storm brought rain of over 140mm in 24 hours Almost 50 cities or municipalities in Santa Catarina state were affected by the cyclone State Civil Defence reported wind speeds of between 60 and 90 km/h in many parts of the state with winds reaching 120km/h in Morro da Igreja Emergency services in Santa Catarina responded to hundreds of calls for assistance during the storm Over 1 million people were left without electricity after winds downed power lines Chapecó; Santo Amaro da Imperatriz; Governor Celso Ramos; Islet; Itaiópolis and Rio dos Cedros One person was reported missing in Brusque Although full details are yet to be confirmed it appears most of the deaths were a result of wind damage According to the Civil Defence in the state of Rio Grande do Sul 1,119 people and 921 homes were affected by rain and strong winds across the country Over 500 people were evacuated in Vacaria and 400 in Capão Bonito do Sul One fatality was also reported in the state of Rio Grande do Sul where heavy rain in Nova Prata is thought to have triggered a landslide that buried a construction worker the cyclone affected 3,127 people in 30 cities damaging over 600 houses and forcing at least 81 people to temporarily leave their homes Warnings remain in place for storm surge and coastal flooding in Santa Catarina So far the heaviest of the rainfall occurred in Rio Grande do Sul Rio Grande do Sul Civil Defence said the heavy rain brought by the storm has increased river levels The Ijuí and Gravataí rivers are close to flood levels The Sinos River is already above the flood stage near Campo Bom and is expected to rise further — Defesa Civil RS (@defesacivilrs) July 1, 2020 Cookies | Privacy | Contacts © Copyright 2025 FloodList This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Unlock discounted publishing that highlights your organization and the peer-reviewed research and clinical experiences it produces Find out how channels are organized and operated including details on the roles and responsibilities of channel editors Offering a variety of advertising and sponsorship options for reaching influential specialists from targeted demographic splits efficient publishing and peer reviewing experience without sacrificing publication times Generate broad awareness and deliver relevant peer-reviewed clinical experiences directly to potential customers Dedicated Cranial Radiosurgery: Clinical Experience with New & Innovative SRS Technologies Real-Time Adaptive Motion Management on Helical and Robotic RT Platforms Please note that by doing so you agree to be added to our monthly email newsletter distribution list Metrics details Many efforts have been made to standardize the interpretation of 18F-FDG PET/CT in multiple myeloma (MM) with qualitative visual analysis or with quantitative metabolic parameters using various methods for lesion segmentation of PET images The aim of this study was to propose a quantitative method for bone and bone marrow evaluation of 18F-FDG PET/CT considering the extent and intensity of bone 18F-FDG uptake: Intensity of Bone Involvement (IBI) Whole body 18F-FDG PET/CT of 59 consecutive MM patients were evaluated Compact bone tissue was segmented in PET images using a global threshold for HU of the registered CT image A whole skeleton mask was created and the percentage of its volume with 18F-FDG uptake above hepatic uptake was calculated (Percentage of Bone Involvement - PBI) IBI was defined by multiplying PBI by mean SUV above hepatic uptake IBI was compared with visual analysis performed by two experienced nuclear medicine physicians IBI calculation was feasible in all images (range:0.00–1.35) Visual analysis categorized PET exams into three groups (negative/mild that had different ranges of IBI (multi comparison analysis There was an inverse correlation between the patients’ hemoglobin values and IBI (r = −0.248;p = 0.02) IBI score is an objective measure of bone and bone marrow involvement in MM allowing the categorization of patients in different degrees of aggressiveness of the bone disease The next step is to validate IBI in a larger group of patients before and after treatment and in a multicentre setting Early and precise evaluation of bone involvement is crucial for staging and correct disease management MTV and TLG only consider areas visually defined as lesions and ignore diffuse uptake of the bone marrow we propose a semi-automatic method to obtain a quantitative parameter for metabolic activity of the bone affected by MM in 18F-FDG PET/CT images defined as Intensity of Bone Involvement (IBI) CT-based bone segmentation is critical to obtain a standardized and reproducible quantitative assessment of bone 18F-FDG uptake since the direct segmentation of PET images is difficult to standardize especially in cases of diffuse involvement IBI calculation was performed in five major steps: pre-processing, CT-based segmentation, bone mask creation, creation of a PET image containing only the bone and bone marrow tissues (PETbone/bm) and metabolic metrics calculation. Figure 1 shows an overview of the process used for IBI calculation. Five major steps for Intensity of Bone Involvement (IBI) calculation (a) Original PET was pre-processed to clean the high intensity areas of physiological uptake and external objects the image was segmented according to the Hounsfield scale (HU) of the registered CT the skull region had to be excluded from the mask to reduce the artifacts caused by the overlapping of brain uptake (for patients with focal lesions on skull a manual correction for IBI can be performed (c) Masked PET was transformed into a binary matrix and a morphological close was performed to achieve the final bone mask (d) Multiplication between bone mask and subtracted PET resulted in the PET image containing only the bone and bone marrow tissues (PETbone/bm) Image pre-processing was performed to reduce the influence of artifacts on metabolic results It included manual extraction of external objects (e.g. patient table and urinary catheter) and subtraction of high intensity areas of physiological uptake (heart etc) through auto-segmentation of the PET image Hounsfield index (HU) higher than 100 was used as a criterion to segment the whole compact bone in the CT image All voxels below this value was set to zero and it corresponded to anatomical contour of compact bone in the functional image the skull region had to be excluded from the mask because the pre-processing was not enough to reduce the artifacts caused by the overlapping of brain uptake a manual correction for IBI calculation was performed  (see bellow) Bone marrow has the same HU range as soft tissues and for this reason it is not included when CT-based segmentation is performed To include the bone marrow in the masked region the Masked PET was turned into a binary image and a morphological close operation was performed using a disk-shaped structuring element with radius of 3 pixels The result was a binary bone mask that included also the medullary cavity Element-wise multiplication of bone mask and subtracted PET was performed everything that is outside the mask was set to 0 The final result was a segmented PET image that shows only bone and bone marrow uptake (“PET bone/bone marrow” or PETbone/bm) PETbone/bm is the foundation image to obtain the metabolic metrics of bone and bone marrow tissue for MM patients Three basic metabolic metrics where directly extracted from the images: maximum SUV of bone tissue (SUVmax) mean SUV of bone tissue (SUVmean) and standard deviation of bone tissue SUV (σ) A volume of interest was defined (VOI) as the volume whose 18F-FDG uptake is above the mean liver uptake plus two standard deviation (\(\overline{SU{V}_{liver}}+2{\sigma }_{liver}\)); this is the volume considered to be metabolically active This VOI comprises any voxel within this criterion even if it is isolated in an area with lower 18F-FDG uptake We defined as percentage of bone involvement (PBI) the fraction of segmented bone tissue whose 18F-FDG uptake is above the liver uptake. PBI is calculated as the division of VOI by the total bone mask volume (BMV), Eq. (1) The other metabolic parameter proposed is the Intensity of Bone Involvement (IBI). IBI is calculated as the multiplication of PBI and mean SUV of the VOI, Eq. (2) it is not based on an absolute volume but on a fraction of volume and second diffuse pattern of 18F-FDG uptake is always included in the calculation For patients with focal lesions in the skull a manual correction for IBI calculation can be performed For a patient with “n” focal skull lesions where SLVi is the volume of the i-th skull lesion manually determined and \({\overline{SUV}}_{i}\) is its respective mean SUV The mean and standard deviation of hepatic SUV of the 59 patients were calculated to assess the variability of this parameter in these patients The patients were instructed to fast for at least 6 hours All patients were scanned from head to feet according to the standard protocol for MM of our center Image acquisitions started 60 min after the injection of 0.12 mCi/kg of 18F-FDG in a Biography mCT40 PET/CT scanner (Siemens Medical The CT part of the study was acquired with 120–140 kV The emission scan was performed in a 3D mode PET images were reconstructed using a standard iterative algorithm (3D-OSEM + PSF+TOF with 2 iterations and 21 subsets) with the CT data utilized for attenuation correction and image fusion A spherical VOI of 34,69 cm3 (radius ∼2,0 cm) was placed in the liver of each image to find the mean and standard deviation of the background SUV The following clinical and laboratory parameters were obtained from patients: stage of disease according to the International Stage System (ISS), hemoglobin, percentage of plasma cell of bone marrow (BM), lactate dehydrogenaze (LDH), serum calcium and creatinine. Patients’ characteristics are described in Table 1 Visual analysis of all whole-body 18F-FDG PET/CT images was performed by two experienced nuclear medicine physicians The criteria to consider 18F-FDG PET/CT as “positive” for MM bone involvement was the presence of hypermetabolic focal bone lesions and/or diffuse increased uptake in the bone marrow Lesion 18F-FDG uptake lower or similar to liver uptake moderately higher or markedly higher than the liver uptake The number of focal lesions on 18F-FDG PET/CT image of each patient was also evaluated by the nuclear medicine physicians Images were classified into four groups: no focal lesions 4 to 10 focal lesions and more than 10 focal lesions Maximum instensity projection (MIP) of PET images of six different patients progressively aligned from left to right according to the extent of bone involvement as stated by a subjective visual analysis of PET images: negative/mild (the two images on the left) moderate (the two central images) and marked bone involvement (the two images on the right) Note that the Intensity of Bone Involvement (IBI) score increases progressively so that the bone/bone marrow involvement can be evaluated as a continuous numerical variable Significant differences in the IBI scores were found between the group of patients with more than 10 focal lesions and the groups with 1–3 and 4–10 lesions (p-value < 0.05) There was an inverse correlation between the hemoglobin values of the patients measured at the time of PET and IBI (r = −0.248; p = 0.02) and PBI(r = −0.264; p = 0.043) but not with \(\overline{SU{V}_{VOI}}\) (r = 0.13; p = 0.14) Focal skull lesions were found in three of 59 PET images The initial IBI values of these patients (without correction for skull region exclusion) were 0.07 After manual correction for the skull lesions The mean hepatic SUV in our group of 59 patients was 2.21 and the standard deviation 0.44 No focal lesions were identified in any of the patients No patient had diffuse liver involvement detectable by FDG-PET/CT Artifacts that may influence Intensity of Bone Involvement score calculation (a) Original (left) and processed (right) images: note the brain uptake overlapping the skull (arrow) (b) Heart uptake overlapping the ribs (circumferences on the original and processed images) (c) Bone mask contour influenced by a metallic femoral prosthesis (arrow) When analyzing 18F-FDG PET/CT images of MM patients it is usually not difficult to identify extra-osseous lesions it is sometimes very challenging to classify bone marrow involvement in the PET scans of many of these patients because both focal and diffuse bone lesions may coexist in MM The IBI score objectively addresses this issue Although this method is very comprehensive and considers different types of osseous and extra-osseous sites of lesions it is not practical in daily routine and does not provide a general parameter that represents the degree of whole bone involvement The simple visual analysis is a practical alternative it is somewhat subjective and depends on the observer’s experience it is of limited reproducibility among different centers Since normal bone marrow FDG uptake is generally lower than hepatic uptake using the liver as an internal reference allowed us to highlight the metabolic activity of the disease in IBI This is because including “normal uptake” (below hepatic) in IBI would reduce the differences between the several degrees of MM involvement mild and moderate bone involvement would have relatively close numerical values if we added the “normal uptake” value to both The central idea of the IBI score is to provide a consistent and objective numerical variable for grading the intensity of bone marrow involvement in MM patients using a measure related to an internal control (liver) both at the initial evaluation as well as for assessment of response to treatment Bone segmentation through the HU scale of CT images is crucial for the reproducibility of the proposed parameter making it less operator-dependent than methods that use only the PET images for segmentation We found that IBI score had a good agreement with the subjective analysis of the extent of bone involvement in 18F-FDG PET/CT images High values of IBI were related to a more extensive and/or intense 18F-FDG uptake allowing patients to be graded according to the intensity of bone involvement the number of focal lesions had a poor agreement with the IBI score mainly when no focal lesions were identified on the 18F-FDG PET/CT images That could be expected since just counting the number of lesions does not consider the presence of diffuse bone marrow involvement anemia can also be due to chronic renal insufficiency and more rarely by hemolysis or myelodysplasia SUV harmonization is essential for comparing results among patients for the same patient in its follow-up or in multicenter trials since IBI utilizes the hepatic SUV as a reference and a large bone volume for calculation (the skeletal mask) the influence of SUV is probably less than for other techniques that use a fixed SUV threshold for lesion segmentation all with relatively small lesions compared to those of the spine and pelvis We manually included the skull lesions in IBI calculation of these patients even though we found no important changes in IBI values after this correction probably due to the small size of these lesions Albeit making the method more operator-dependent this manual option can be used in selected cases with extensive cranial involvement or other imaging artifacts since no focal liver lesion or diffuse involvement was detected We found a mean liver SUV of 2.21 with a standard deviation of only 0.44 in these patients The mean liver SUV of 2.21 found in our MM patients with no known liver disease could also be used as fixed threshold the operator should simply avoid overlap them when drawing the reference liver ROI Although we had no cases in which lytic lesions were excluded in the proposed method for bone masking it is theoretically possible that very extensive lytic lesions could not be incorporated by the bone mask since the HU scale of that region would be very different from a healthy bone tissue manual contour corrections of the masks should be performed IBI does not evaluate isolated extra-osseous MM lesions and the method described here has some complexity but the image processing steps used for PBI and IBI calculation are available on many commercial workstations and image software (including some free ones morphological operations and matrix multiplication which are simple operations compared to machine and deep learning We believe it can be an accessible method in terms of operational complexity and feasible in clinical practice The proposed IBI score is an objective measure of bone marrow lesions in patients with MM with different degrees of bone involvement It may allow comparisons among patients in multicenter settings and measurements before and after treatment It seems to be a feasible parameter for use in clinical practice and research Further studies are needed to evaluate the possible clinical role of IBI in patients with MM The datasets generated during and/or analyzed during the current study are not publicly available due to protect the identity of research subjects but are available from the corresponding author on reasonable request risk stratification and response assessment of multiple myeloma Contrast enhanced MRI and 18F-FDG PET-CT in the assessment of multiple myeloma: A comparison of results in different phases of the disease Diagnostic performance of 18 F-FDG PET/CT and whole-body MRI before and early after treatment of multiple myeloma: a prospective comparative study Comparative diagnostic performance of 18F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation Interpretation criteria for FDG PET/CT in multiple myeloma (IMPeTUs): final results IMPeTUs (Italian myeloma criteria for PET USe) Image interpretation criteria for FDG PET/CT in multiple myeloma: a new proposal from an Italian expert panel IMPeTUs (Italian Myeloma criteria for PET USe) Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma Assessment of total lesion glycolysis by 18F FDG PET/CT significantly improves prognostic value of GEP and ISS in myeloma Current methods to define metabolic tumor volume in positron emission tomography: which one is better Assessment of bone segmentation quality of cone-beam CT versus multislice spiral CT: a pilot study Oral Surg Oral Med Oral Pathol Oral Radiol Endod Quantitative evaluation of bone density using the Hounsfield index Effects of CT image segmentation methods on the accuracy of long bone 3D reconstructions CT image segmentation methods for bone used in medical additive manufacturing Tumor treatment response based on visual and quantitative changes in global tumor glycolysis using PET-FDG imaging: the visual response score and the change in total lesion glycolysis Landgren, O. & Rajkumar, S. V. New Developments in Diagnosis, Prognosis, and Assessment of Response in Multiple Myeloma. Clin Cancer Res., https://doi.org/10.1158/1078-0432.CCR-16-0866 Fiji: an open-source platform for biological-image analysis Identification and importance of brown adipose tissue in adult humans Image Processing Toolbox: For Use with MATLAB [user’s Guide] Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma Prognostic value of metabolic tumor burden on 18 F-FDG PET in nonsurgical patients with non-small cell lung cancer 18F-FDG PET/CT metabolic tumor volume and total lesion glycolysis predict outcome in oropharyngeal squamous cell carcinoma Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18F-FDG PET/CT in patients with pancreatic cancer Prognostic value of volumetric parameters of 18 F-FDG PET in non-small-cell lung cancer: a meta-analysis Metabolic tumor volume metrics in lymphoma Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection Klein, A. et al. Automatic bone segmentation in whole-body CT images. Int J CARS., https://doi.org/10.1007/s11548-018-1883-7 (2018) Update on the use of erythropoiesis-stimulating agents (ESAs) for the management of anemia of multiple myeloma and lymphoma Standards for PET image acquisition and quantitative data analysis EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies A systematic review of the factors affecting accuracy of SUV measurements Comparison of 11C-Choline and 11C Methionine PET/CT in Multiple Myeloma (18)F-fluoro-ethyl-tyrosine ((18)F-FET) PET/CT as a potential new diagnostic tool in multiple myeloma: a preliminary study The role of 68Ga-DOTA-TATE PET/CT scanning in the evaluation of patients with multiple myeloma: preliminary results Rasche, L., Kortüm, K.M., Raab, M.S. & Weinhold, N. The Impact of Tumor Heterogeneity on Diagnostics and Novel Therapeutic Strategies in Multiple Myeloma. Int J Mol Sci., https://doi.org/10.3390/ijms20051248 State of the art imaging of multiple myeloma: comparative review of FDG PET/CT imaging in various clinical settings Current concepts in MRI of focal and diffuse malignancy of bone marrow Detection of Extramedullary Multiple Myeloma in Liver by FDG-PET/CT 18F-FDG PET/CT in primary AL hepatic amyloidosis associated with multiple myeloma Download references We thank the Nuclear and Energy Research Institute (IPEN-CNEN) for kindly supplying the radiopharmaceuticals used in the present project (IPEN/UNICAMP agreement No We are grateful for financial support from FAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo) Grant Numbers 2009/54065-0 and 2018/00654-4 The study was also partially financed by Cooperação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) finance code 001 ILM has a research grant from CNPq (National Council of Research) proc 305110/2018-7 CDR has a research grant from CNPq (National Council of Research) proc 311841/2018-0 made substantial contributions to the conception or design of the work were responsible for acquisition and/or interpretation of data to which all authors contributed edits throughout have first approved the submitted version and were followed by all the other authors The authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-019-52740-2 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research Elanco Animal Health IHT Group LANXESS PigTek Connections April 2025 BinSentry PigCentral™ Management System from PigTek Hog Slat The Maschhoffs recognize an employee who has displayed the company core values through key business decisions and leadership actions The Core Values award is a prestigious honor that recognizes the outstanding commitment of a single individual The company core values are how The Maschhoffs operate The below set of values serve as an authentic reflection of the company culture They define how employees collaborate with one another notes that “Paul Ayers is a dedicated member of the Maschhoff team for nearly 15 years He exemplifies our core values through his unwavering commitment to excellence.” As a leader Paul has adapted seamlessly to changing directives and initiatives within the company demonstrating his versatility and creativity His steadfast focus on upholding the highest standards in animal care and welfare has been instrumental in ensuring our company’s success Paul’s proactive approach to embracing new responsibilities such as managing sustainability reports and system improvements showcases his innovative thinking and dedication to progress “His ability to foster strong relationships both internally and externally coupled with his continual pursuit of improvement makes him a deserving candidate for the Core Values Award.” adds that “everything Paul does is through the lens of helping people be better stewards of our animals and the business Paul partnered with others across the business to bring to life a celebration of our efforts around sustainability and best practices in the stewardship of our resources Paul kept up with his day job as Animal Care Manager and found time to dedicate to sharing his passion and knowledge at industry events Paul is a shining example of what it means to live our core values and he does so in a very humble and authentic way The Maschhoffs had an astounding 44 finalists for 2024: To learn more about The Maschhoffs core values, visit www.themaschhoffs.com However, this hasn't stopped travelers from dreaming of future trips and planning their next vacation From a cave dwelling overlooking the ocean on a Greek island to a treehouse in Bali these are the places travelers can't wait to visit Global Climate Agreements: Successes and Failures How Tobacco Laws Could Help Close the Racial Gap on Cancer Could Trump’s Tariffs Replace Income Tax for the Bottom 90% Peter McColough Series on International Economics With Robert E The U.S. Government Accountability Office (GAO) released a detailed report last week that criticizes attempts to patrol the Arizona-Mexico border using high-cost technologies The report comes ten months after the cancellation of SBInet Boeing’s “virtual” fence project that started in November 2005 and eventually cost the United States over one billion dollars While the project in theory required less manpower and provided 24/7 patrols of the border using surveillance towers and software platforms Criticism of SBInet ranged from outright technological failures Although the Department of Homeland Security ended SBInet’s expansion, the GAO report makes clear that the broader emphasis on such technologies has hardly waned The flawed SBInet system will actually continue to operate along 53 miles of Arizona’s 387-mile border with Mexico and Customs and Border Patrol (CBP) estimates spending $36 million dollars to continue that project through 2012 the Arizona Border Surveillance Technology Plan will be a mixture of different surveillance technologies and platforms with funding requests totaling $427 million over the next two years The GAO report indicates that the new systems also lack quantifiable metrics or thorough cost-benefit analyses; some of the same problems that plagued SBInet “virtual” fence technologies seem like an answer to immigration issues along the U.S.-Mexico border like other attempts to wall-off Mexico from U.S 43,000+ global companies doing business in the region 102,000+ key contacts related to companies and projects news and interviews about your industry in English Metrics details Cisplatin (CDDP) combined with radiotherapy (RT) is employed in head and neck squamous cell carcinoma (HNSCC) with variable toxicities and clinical response Glutathione S-transferases (GSTs) participate in CDDP excretion from cells This prospective study aimed to evaluate the roles of GSTM1 and GSTP1 Ile105Val polymorphisms in outcomes of HNSCC patients treated with CDDP chemoradiation Ninety patients were genotyped by multiplex PCR Urinary CDDP measurements were performed by HPLC Treatment side effects and response were analysed by conventional criteria Patients with GSTT1 genes showed 7.23- and 5.37-fold higher likelihood of presenting vomiting and ototoxicity and lower elimination of CDDP in urine relative to patients with deleted genes Patients harbouring the GSTP1 IleVal or ValVal genotypes showed 4.28-fold higher likelihood of presenting grade 2 or 3 vomiting and lower GFR with treatment than those harbouring the IleIle genotype patients with the GSTP1 105ValVal genotype had 3.87 more chance of presenting disease progression than those with the IleIle or IleVal genotype (p < 0.01) Our findings provide preliminary evidence that inherited abnormalities in CDDP metabolism related to GSTT1 and GSTP1 Ile105Val polymorphisms alter outcomes of HNSCC patients treated with CDDP and RT Variability in patient responses can be caused by differences in genetic regulation of metabolic pathways Considering the limited number of studies that investigated these genes we conducted this prospective study to determine whether the GSTM1 and GSTP1 Ile105Val polymorphisms alter toxicity and survival in HNSCC patients treated with CDDP and RT All patients were homogenously treated with RT at a total dose of 75 Gy and 80–100 mg/m2 of CDDP as initial dose as previously described (100 mg/m2 of CDDP was administered to patients with Karnofsky Performance Scale (KPS) 80–100% and without comorbidities and patients with KPS 60–70% without comorbidities or KPS higher than 70% with comorbidities received CDDP at dose of 80 mg/m2) As recommended by the institutional protocol 13 patients who presented adverse side effects of grades 3 or 4 received CDDP at lower dose (50–75 mg/m2) in further administrations or had suspension of CDDP A total of 68 patients (75.5%) received three infusions of CDDP while 22 patients (24.5%) received only two CDDP infusions because of hematologic or renal toxicities Urinary cisplatin (CDDP) and probability of event-free survival (EFS) of patients with head and neck squamous cell carcinoma treated with CDDP-chemoradiation Average levels of CDDP after three CDDP infusion in 43 patients who collected urine in all three periods proposed in study where *shows difference between CDDP excretion in 0–12 and 12–24 hours (p < 0.001) and **shows difference between CDDP excretion in 0–12 and 24–48 hours (p < 0.001) (A) Total CDDP urinary concentration in the same stratified by GSTM1 where *shows difference between patients with GSTT1 null genotype and patients with GSTT1 wild-type genotype (p = 0.04 Probabilities of EFS by Kaplan-Meier estimates in 90 patients stratified by genotypes of the GSTP1 Ile105 Val polymorphism (C) All cases were followed-up for a median period of 21 months (range: 3.0–74) The cumulative probabilities of event-free survival (EFS) and overall survival (OS) at 24 months follow-up were 35.0% and 40.0% of which 6 had HNSCC and 17 did not have HNSCC of which 59 mortalities were associated with tumour effects and eight were attributed to unrelated causes The polymorphisms at the GSTP1 Ile105Val locus in the analyzed participants were in Hardy-Weinberg equilibrium (HWE) (χ2 = 2.80 and GSTP1 IleIle genotypes showed the highest reported total CDDP elimination rate (545.42 µg CDDP/mg creatinine) A history of tobacco and alcohol consumption but the low prevalence of HPV infection indicate that history of tobacco and alcohol consumption were in fact the most important factors influencing tumour development in the analysed patients Our previous findings indicated that the GSTP1 IleVal or ValVal genotype was associated with vomiting; in the current study vomiting was strongly associated with the presence of both GSTT1 and the GSTP1 IleVal or ValVal genotype The contrasting results between the two studies can be attributed to the differences in patient stratification based on the severity of vomiting grade patients were stratified based on grade 0 or 1 vs whereas patients in the present study (n = 90) were stratified based on grade 0 vs which could have modified the effects of the GSTT1 gene increased apoptosis of CDDP-damaged enterochromaffin cells of the intestines which is associated with the less active “Val” allele of the GSTP1 Ile105Val polymorphism may have influenced the severity of vomiting in the HNSCC patients They postulated that nutrient deficiency with lack of GSH production and impaired detoxification of free radicals of CDDP in the sensory inner ear cells consequently increased ototoxicity The same mechanisms are likely to occur in HNSCC patients in the present study and GSTP1 IleIle genotypes showed the highest total CDDP elimination rate we are aware that the number of patients enrolled in study was not large and that further larger studies and functional analyses of relevant polymorphisms are required to confirm the roles of these GSTs in disease HNSCC patients diagnosed at the Clinical Oncology Service of the General Hospital of University of Campinas between June 2011 and February 2014 were selected to undergo CCDP chemoradiation as definitive treatment due to locoregional unresectable tumour refusal of surgery related to expected functional or anatomic sequels or an organ preservation protocol The following exclusion criteria were considered: (1) refusal to participate in the study; (2) low KPS score; (3) renal dysfunction; (4) previous hearing dysfunction; and/or (5) other therapeutic protocol The present study was conducted according to the Declaration of Helsinki and was approved by the Ethics Committees of the University of Campinas (n° 274/2011; CAAE: 0218.0.146.000-11) All patients provided written informed consent after they were informed about the study and any associated risks the worst grade for each toxicity was included in analysis Surgical tumour resection was indicated to patients with good clinical condition and partial response or tumour relapse Patient follow-up was performed in three-month intervals The end of the follow-up period was September 2018 Positive and negative controls were used in all genotyping reactions The amount of 15% of genotype determinations was carried out twice in independent experiments and showed 100% of concordance Sample measurement and standard curves were performed in duplicate Urinary CDDP was normalized with urinary creatinine and measured using akinetic kit (Creatinine Laborclin kit The final concentration of urinary CDDP was calculated as the sum of all measurements obtained after each CDDP administration EFS and OS were calculated for each participant from the date of diagnosis until the date of tumour progression or last follow-up and from the date of diagnosis until the date of death by any cause or last follow-up contact Kaplan-Meier method was used to plot EFS and OS curves and log-rank test was conducted to determine significant differences between curves Multivariate Cox regression was used to estimate hazard ratios (HRs) adjusted for potential possible discrepancies in clinical aspects (p ≤ 0.10 in univariate Cox regression) Bootstrapping (n = 1,000) based on repeatedly random sampling was applied to ensure the stability of the model by applying the bias-corrected and accelerated method P-values were two-sided and considered statistically significant at p < 0.05 Statistical analyses were conducted using SPSS 21.0 software (IBM Corporation The authors declare that all data of this study are available from the corresponding author upon reasonable request The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma Cisplatin in cancer therapy: molecular mechanisms of action Biological consequences of radiation-induced DNA damage: relevance to radiotherapy Cisplatin-associated ototoxicity: a review for the health professional Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study Mechanisms of invasion in head and neck cancer Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy Glutathione S-transferase polymorphisms: cancer incidence and therapy Glutathione-S-transferase family of enzymes Do genetic polymorphisms modulate response rate and toxicity of cisplatin associated with radiotherapy in laryngeal squamous cell carcinoma?: a case report Genetic risk factors of cisplatin induced ototoxicity in adult patients XPF c.2505T > C and CASP9 c.-1339A > G Polymorphisms and severity of vomiting in head and neck cancer patients treated with cisplatin chemoradiation Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer High-dose cisplatin concurrent to conventionally delivered radiotherapy is associated with unacceptable toxicity in unresectable non-metastatic stage IV head and neck squamous cell carcinoma Pharmacogenetics of chemotherapy-induced nausea and vomiting Evaluation of patients with head and neck cancer performing standard treatment in relation to body composition Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1 Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with meduloblastoma Ototoxicity: mechanisms of cochlear impairment and its prevention Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients A Comprehensive review on the genetic regulation of cisplatin-induced nephrotoxicity High performance liquid chromatographic determination of platinum in blood and urine samples of cancer patients after administration of cisplatin drug using solvent extraction and N,N′-bis(salicylidene)-1,2-propanediamine as complexation reagent Population pharmacokinetic analysis of cisplatin and its metabolites in cancer patients: possible misinterpretation of covariates for pharmacokinetic parameters calculated from the concentrations of unchanged cisplatin Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study Glutathione S-transferase genotypes and cancer risk Association of GSTP1 polymorphism and survival for esophageal cancer Free radicals hasten head and neck cancer risk: A study of total oxidant Organic anion transporter 5 (Oat5) urinary excretion is a specific biomarker of kidney injury: evaluation of urinary excretion of exosomal Oat5 after N-acetylcysteine prevention of cisplatin induced nephrotoxicity Protective role of misoprostol against cisplatin-induced ototoxicity Cost-minimization analysis of GSTP1 c.313A > G genotyping for the prevention of cisplatin-induced nausea and vomiting: a Bayesian inference approach Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2) A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading American Joint Committee on Cancer: Cancer Staging Manual XPD c.934G > A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation National Cancer Institute. Cancer therapy evolution program. Common terminology criteria for adverse events (CTCAE) v 4.0, 2009. Available at, http://ctep.cancer.gov New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) Human Genetic Diseases: A Practical Approach Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis Glutathione S-transferase P1 genotype and prognosis in Hodgkin’s lymphoma Validation of an AAS method for the determination of platinum in biological fluids from patients receiving the oral platinum derivative JM216 Urine analysis of platinum species derived from cis-dichlorodiammineplatinum(II) by high-performance liquid chromatography following derivatization with sodium diethyldithiocarbamate A high-performance liquid chromatographic assay for determination of cisplatin in plasma Park, H. M. Hypothesis testing and statistical power of a test. Working Paper. The University Information Technology Services (UITS), Indiana University. In, http://www.indiana.edu/~statmath/stat/all/power/index.html Download references We thank Miss Cleide Aparecida Moreira Silva and Miss Juliana Luz Passos Argenton from the Faculty of Medical Sciences for the statistical analysis guidance This work was supported by “Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (grant number 2012/1807-2) Department of Ophthalmology and Otolaryngology made relevant contributions to the conception of work made relevant contributions to conception of the work performed identification and control of side effects and conducted the urinary C.D.D.P analysed histological grade and human papillomavirus type 16 status analysed computed tomography images of the necks of patients analysed glomerular filtration rate measured by 51Cr-EDTA was responsible for the concept and study design All authors approved the final version of the manuscript Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and 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Middle East Close menu Countries North America North America Close menu Countries South America South America Close menu Countries Many travellers are wish-listing the Hobbit Hole in Washington © Airbnb Now that our thoughts are turning to travel again people are dreaming about where they might go on future trips These are the top ten rentals wish-listed by Airbnb guests so you can see the top properties currently fuelling wanderlust This adorable hobbit hole sleeps two people in a queen-sized bed, and it is nestled right in the Columbia River Gorge mountainside, located in Orondo, Washington and there are six acres to hike around and explore or you can just chill out at the indoor fireplace The majority of your neighbours will be deer Dar Ahwach is a charming renovated riad at the heart of the Moroccan ancestral culture located 8km from Jamaa el Fna square and close to the souks a dining room and a fully-equipped kitchen A housekeeper is on hand to take care of guests and breakfast is 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Find out how COVID-19 is changing travel. Governador Celso Ramos, Brazil - August 2019 - Last August 6, in the town of Governador Celso Ramos, numerous faithful, especially children and young people from the Salesian parish "São João Bosco" in Itajaí, celebrated the opening the Month of Vocations 2019 of the Archdiocese of Florianópolis, under the motto: "In every community a new vocation". In all, circa 4,500 people participated. ANS - “Agenzia iNfo Salesiana” is a on-line almost daily publication, the communication agency of the Salesian Congregation enrolled in the Press Register of the Tibunal of Rome as n 153/2007. This site also uses third-party cookies to improve user experience and for statistical purposes. By scrolling through this page or by clicking on any of its elements, you consent to the use of cookies. To learn more or to opt out, click "Further Information". This website is using a security service to protect itself from online attacks. 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BV-FAPESP: research projects supported in this Center  CancerThera in the Media: news about the Center Cancer is a major global public health problem and is among the leading causes of death The identification of new agents for the diagnosis and treatment of patients with tumors is highly desirable metals have been used empirically to treat various diseases metals and their compounds – stable or radioactive – are applied rationally in neoplasms The "Center for Innovation in Cancer with Emphasis on Metals and Theranostics (CancerThera)" will develop research innovation and knowledge dissemination activities for the creation of new metal-based drugs and radiopharmaceuticals for the diagnosis and treatment of cancer It will also study new uses for known radiopharmaceuticals It will bring together researchers from various areas of knowledge adopting an innovative model in the country to become a world-class center in the study of cancer The research will be divided into two interconnected arms: Basic Research and Clinical Research The two arms will develop convergent projects producing internationally competitive research and training highly qualified human resources in the creation manipulation and diagnostic and theranostic use of metal-based drugs and radiopharmaceuticals such as nucleotide analogues and semicarbazones among others new metallo-drugs with action potential in the diagnosis and blocking of tumor cell replication will be synthesized New metal chelation systems of the type bis (semicarbazones) and bis (thiosemicarbazones) will be emphasized These and other chelators will be conjugated with several peptides related to the tumor microenvironment The compounds will be radiolabeled mainly with the gallium-68/lutetium-177 pair – which respectively enable the diagnosis and treatment (theranostic) of neoplasms – in addition to other radioisotopes The biodistribution and anti-tumor action of the compounds will be evaluated in several preclinical studies assays of antiproliferative activity and cell death in tumor cell lines and in inflammation/gene expression assays of toxicity and efficacy in animal models Clinical Research: simultaneously with the basic arm possible new uses for molecules already known such as the prostate-specific membrane antigen (PSMA) but which will be used only in non-prostatic neoplasms and the fibroblast activation protein inhibitor (FAPI) With the existing radiopharmacy infrastructure in the host institution currently in addition to the current international project several radioisotopes will be used to mark these substances that will be tested in the diagnosis and possible treatment of various neoplasms squamous cell carcinoma of the head/neck and skin and Ph1-negative chronic myeloproliferative diseases (mainly primary myelofibrosis) will be initially studied The genetic analysis of the catchment lesions will be made FORMER Philippine Olympic Committee (POC) President and one time Commissioner of the Philippine Sports Commission (PSC) Celso Dayrit passed away Wednesday night due to health reasons Dayrit served as head of the country’s Olympic governing body from 1999 to 2004 and was commissioner of the sports government agency under the time of President Fidel Ramos has long been associated with the sport of fencing as his father Don Francisco ‘Paco’ Dayrit Sr was considered the ‘Father of Philippine Fencing’ and founded in the 1930s the Philippine Amateur Fencers Association which is now known as the Philippine Fencing Association Celso Dayrit himself became head of the federation from 1997 to 2008 He would later take his act of propagating fencing within Asia as he became President of the Fencing Confederation of Asia since 2005 until the time of his death "Celso Dayrit is a big loss to sports world wide being a former president of the Philippine Olympic Committee including the presidency of the Philippine and Asian fencing federations," said Philippine Journalists Inc Editor In-Chief Augusto 'Gus' Villanueva who was media liason officer of the POC during the time when Dayrit was at the helm of the local Olympic body "Let's pray for the eternal repose of his soul Dayrit led POC with the noblest principles and was hardworking Both the POC and PSC likewise remembered the legacy Dayrit left in them He is one of my very first friends in sports and I have always admired his deep understanding of Olympism and sports dynamics in the country He will be truly missed," said PSC Chairman William 'Butch' Ramirez POC President Abraham 'Bambol' Tolentino referred to Dayrit as 'one of my mentors.' he gave me one message that I will publish soon," said Tolentino "He was big help to me in foreign relations especially in the Southeast Asian Games Federation Dayrit’s extensive work not only in fencing but also in the entire sports community had been recognized by no less than the International Olympic Committee (IOC) which made him the only Filipino accredited International course Director of the Olympic Solidarity Itinerant Administration School for sports leaders He was awarded in 2007 by the Olympic Council of Asia (OCA) and was given the Olympic Merit Award in 2006 by the Association of National Olympic Committees (ANOC) which was personally handed out by former IOC President Jacques Rogge Dayrit is also an Honorary Member of the Federation Internationale D’Escrime and representative of the Veteran’s Council He likewise founded the Philippine Olympic Academy and the Philippine Olympians Association “I am filled with immense sadness at Cito Dayrit’s passing,” said former POC President and Association of Boxing Alliances in the Philippines (ABAP) head Ricky Vargas “He was a friend and valued adviser and I relied on his professionalism “Philippine and international sports just suffered a devastating loss.” Get more of the latest sports news & updates on SPIN.ph Spin.ph has been granted the NPC Seal of Registration in recognition of the successful registration of its DPO and DPS We use cookies to ensure you get the best experience on Spin.ph. By continued use, you agree to our privacy policy and accept our use of such cookies. Find out more here Roll of Successful Examinees in theREGISTERED ELECTRICAL ENGINEERS LICENSURE EXAMINATIONHeld on AUGUST 24 AND 25