Rice University has launched the Institute of Health Resilience and Innovation (IHRI) a pioneering research initiative dedicated to understanding the lifetime impacts of health stressors and developing targeted interventions to improve well-being across diverse populations distinguished professor of sociology at Rice psychological and social factors interact over time to shape health outcomes By bridging scientific discovery with real-world applications IHRI seeks to promote health resilience at both the individual and community levels.“The launch of the Institute of Health Resilience and Innovation exemplifies Rice University’s commitment to leading in health innovations — a strategic priority for our institution,” Rice President Reginald DesRoches said “By leveraging our strengths in interdisciplinary research and collaborating with the Texas Medical Center we are poised to make meaningful contributions to understanding and improving health resilience This institute will not only generate groundbreaking discoveries but also translate them into real-world solutions that benefit individuals and communities both in Houston and beyond.”“The Institute of Health Resilience and Innovation embodies Rice’s dedication to tackling society’s most pressing challenges through interdisciplinary research,” said Rachel Kimbro “By combining expertise from multiple disciplines including those grounded in the social sciences IHRI will generate insights that lead to actionable solutions advancing health resilience for individuals and communities I’m proud to see our faculty leading this vital work and collaborating across disciplines to drive meaningful change.”Comprehensive approach to health resilience IHRI is pioneering a “cells-to-society” approach to understanding health investigating how social determinants — including socioeconomic status geographic location and social conditions — shape well-being over a lifetime By connecting molecular-level changes within cells to broader social and environmental influences the institute seeks to build a holistic understanding of health resilience and uncover the complex pathways that drive differences in health trajectories across the lifespan.“This institute reflects Rice’s commitment to advancing innovations in health,” Fagundes said “By bringing together experts from multiple disciplines and fostering collaboration we aim to uncover how individuals and communities can better withstand and recover from health challenges Our research will lead to real-world solutions that strengthen resilience at every level: biological social and environmental.”Once risk patterns are identified spanning all levels IHRI will target the most strategic intervention points to drive positive change strengthening community and individual resilience and creating tailored strategies the institute will work to close health gaps and enhance well-being across populations 713-348-0000 | Privacy Policy | Campus Carry This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page We mournfully announce the passing of Dorothy A the daughter of John Webster and Ann Dorothy (Gaffney) Douse She is predeceased by her parents and her husband of 53 years Dorothy’s family moved to Vallejo during her middle school years She began teaching in parochial schools in Los Angeles and San Francisco she enjoyed teaching at Napa County’s one-room schoolhouse Diversified teaching for young students came naturally to Dorothy She enjoyed teaching and administrating at St Catherine Parochial Elementary School in Vallejo Dorothy later earned her Special Education Certification so she could focus on teaching reading After time with the John Swett Unified School District she was excited to work with the Travis Unified School District in Fairfield It was here that she was able to maximize her talents and was an integral part in Travis AFB Elementary School increasing its rating thus becoming one of  California's top-ranked schools Dorothy also assisted with the operation and management of the family Tishara-Fagundes Livestock Ranch in Jamieson Canyon She shared her love for many of their ranch animals with her students bringing “guest” visitors to the classroom Family and friends may remember some of the ranch residents Dorothy’s energy and charisma will be missed She had a passion for researching genealogy and traveling to spend time with friends and family A Celebration of Life will be held at 11 a.m Interment will immediately follow in Tulocay Cemetery at the Tishara grandparents’ site please consider donating to the Tulocay Cemetery Digitization Project Funeral homes often submit obituaries as a service to the families they are assisting we will be happy to accept obituaries from family members pending proper verification of the death Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Account processing issue - the email address may already exist Have the latest local news delivered every afternoon so you don't miss out on updates Receive occasional local offers from our website and its advertisers summary of the weather details and news of any severe weather We'll send breaking news and news alerts to you as they happen  Receive our newspaper electronically with the e-Edition email Invalid password or account does not exist Submitting this form below will send a message to your email with a link to change your password An email message containing instructions on how to reset your password has been sent to the email address listed on your account The element requested is either not valid or does not exist Log in for full access to stabroeknews.com Only one active session is allowed per subscriber Four years after his gunning down in front of Palm Court the family of gold miner Ricardo Fagundes also known as ‘Paper Shorts’ called for a reopening of the case to facilitate a comprehensive investigation family and friends gathered outside Palm Court with placards and his sister Tessa Fagundes extended a call to President Irfaan Ali Minister of Home Affairs Robeson Benn and Commissioner of Police Clifton Hicken to reopen the case and conduct a thorough investigation said that the family originally began protesting on the 21st of every month but this was later contracted to mostly an annual event to commemorate the day of his death She added that the family remained distraught that justice continues to elude them the Guyana Police Force was yet to arrest any suspects It is something we can’t get over and nobody have answers to give us That is worse because they all know what is going on but keeping it as a secret We protest sometimes on his birthday [he would have been 47 in May] and the day of his death,” she said we had the funeral and that’s it… we not hearing anything No police didn’t come to say anything and it just leave we in grief all the time.” the family was invited to the Criminal Investigation Department (CID) to review CCTV footage taken from cameras in the surrounding area The police then informed the family that a car suspected to have been used by the killers A burnt vehicle found at Swan Village on the Soesdyke-Linden Highway hours after the shooting was allegedly used in the crime That was the last official police communication to be had by the family was never informed of the outcome of the investigation at any of its various stages nor whether any tests conducted or anyone was formally suspected to be linked to the execution of Ricardo footage was secured from Palm Court but the family believes there were more cameras in the vicinity “A lot of business places should have footage of the incident when it occurred but they only use the one from Palm Court where nobody couldn’t recognize who it was,” Tessa Fagundes said two persons jump out of a car and start shoot up my brother.” The sister tearfully explained that the family will continue to demand justice until someone is held culpable was riddled with bullets by two men outside Palm Court around 10 pm on Sunday Fagundes was with a colleague in Palm Court when he received a call on his phone Fagundes was later found lying in a pool of blood on the road he was approaching a parked vehicle owned by convicted drug trafficker Roger Khan An autopsy later revealed that Fagundes was shot about 20 times about his body The results of ballistic tests conducted on the spent shells and bullets recovered from the victim’s body were never disclosed Compounding the uncertainty is the police’s prolonged silence on the progress of the investigation fuelling speculation about whether any breakthroughs have been made Among the lingering uncertainties are whether authorities have identified the alleged shooters through analysis of security footage and if they have traced the origin of the AK-47 assault rifle used in the crime Sources had told Stabroek News that the police recovered 30 spent shells at the scene while the other 14 were from a 9mm-calibre gun Rondell Bacchus was initially arrested by the police in relation to the murder Bacchus’s attorney Damien DaSilva had informed Stabroek News that his client was released on $100,000 station bail after the statutory 72-hour period in which he could be held without charge elapsed Bacchus had turned himself over to the police about an hour after a wanted bulletin was issued for him in connection with the murder of Fagundes during a speech at Fagundes’ funeral service Khan had claimed that he was the real target of the shooting Khan had also appealed to President Irfaan Ali for a “clean and impartial” investigation Superintendent of Police Mitchell Caesar and Mohamed’s Enterprise distanced themselves from corruption allegations made by Detective Sergeant Dion Bascom about the investigations into the killing of Fagundes who was Deputy Head of the Guyana Police Force’s Major Crimes Unit Azruddin Mohamed and an employee of Mohamed’s demanded that Bascom retract allegations he made in a later deleted Facebook video and publicly apologise or face lawsuits All three men were represented by attorneys from Poonai and Poonai law firm — a connection that a defiant Bascom pointed out in another video where he said he stood by everything he had previously posted attorney Sohan Poonai called on Bascom to cease and desist from making further allegations about his client issue a retraction and unqualified apology and pay monetary damages within seven days The lawyer indicated that should Bascom fail to do so legal proceedings would be instituted against him for defamation of character and in excess of $50 million in damages The letter by attorney Naresh Poonai on behalf of Mohamed made similar demands but indicated that the monetary damages that would be sought would be in excess of $25 million Bascom had also alleged that a senior CID officer received a $30 million bribe to bury the matter Bascom was subsequently interdicted from duty and placed on half month pay following his arraignment on cybercrime charges the cybercrime charges against Bascom by the GPF were dismissed after the prosecution failed to prove its case Magistrate Leron Daly upheld a no-case submission ruling that the prosecution did not provide evidence linking Bascom to the transmission of electronic data as alleged he was also found guilty of committing cyber crimes against Superintendent Mitchell Caesar and Sergeant Kester Cosbert The ruling was handed down by Magistrate Fabayo Azore at the Vigilance Magistrate’s Court A FREE roundup of top news from Guyana you might otherwise miss 2024 - WASHINGTON — A California man has been arrested for allegedly assaulting law enforcement and other charges related to his alleged conduct during the Jan His alleged actions and the actions of others disrupted a joint session of the U.S Congress convened to ascertain and count the electoral votes related to the 2020 presidential election             Michael Fagundes is charged in an indictment filed in the District of Columbia with three felony offenses or impeding certain officers and one count of obstruction of law enforcement during a civil disorder             In addition to the felonies Fagundes is charged with misdemeanor offenses of entering and remaining in a restricted building or grounds disorderly and disruptive conduct in a restricted building or grounds engaging in physical violence in a restricted building or grounds act of physical violence in the Capitol grounds or buildings and parading demonstrating or picketing in a Capitol building             The FBI arrested Fagundes on Oct and he made his initial appearance in the Central District of California.              According to court documents Fagundes attempted to attend the former President's "Stop the Steal" rally on Jan Capitol building and eventually arrived at the Lower West Terrace Tunnel the site of some of the most violent attacks against law enforcement on that day             It is alleged that Fagundes reached the Tunnel entrance at about 2:42 p.m He then made his way inside the Tunnel and shortly exited before returning and approaching a group of rioters who were attempting to take control of a police riot shield It is alleged that Fagundes himself took possession of the riot shield from the group and emerged from the Tunnel proudly displaying it over his head He then tossed the shield onto the ground before making his way back into the Tunnel and toward the police line the rioters inside the Tunnel began a heave-ho movement against the police line but were quickly forced out of the Tunnel by police             As the rioters were forced out a Metropolitan Police Department (MPD) officer was forcibly dragged from the police line at the entrance to the Tunnel and into the crowd of rioters Fagundes shouted and moved in their direction and Fagundes allegedly reached toward the officer a few times before grabbing ahold of the officer's chest and neck and dragging the officer further into the crowd.Still Image #12A – Closeup of #12 showing FAGUNDES grabbing Officer M.F             Around 3:50 p.m. it is alleged that Fagundes placed his hand on the handle of an Oleoresin Capsicum (OC) dispenser held up by another rioter and appeared to try and manipulate the trigger or safety mechanism another rioter took possession of the dispenser and sprayed it into the Tunnel towards the police line Court documents say that rioters on the Lower West Terrace continued to assault police officers both inside and at the mouth of the Tunnel pushed their body weight back and forth into the police line in a "heave-ho" motion             By about 4:09 p.m. Fagundes picked up a police riot shield near the entrance to the Tunnel and used it to push against other rioters who were pushing against the police line Fagundes once again made his way towards the front of the mob and reached the police line Fagundes allegedly picked up a police riot shield from the ground raised his green backpack and the shield directly over his head and then rapidly dropped the backpack and the shield down in a striking motion in the direction of the officers The shield and the backpack appeared to make contact with at least one officer             Sometime in the afternoon Fagundes appeared to be on a video call with another individual while he was adjacent to the continued violence against police and immediately next to a broken window that led to the inside of the U.S Fagundes then appeared to gesture toward the crowd and he entered the Capitol. Still Images #1-3: FBI Public Website Photos of FAGUNDES on January 6 Attorney’s Office for the District of Columbia and the Department of Justice National Security Division’s Counterterrorism Section prosecuted this case Attorney’s Office for the Central District of California provided valuable assistance             This case is being investigated by the FBI's Los Angeles and Washington Field Offices Fagundes was identified on the FBI's seeking information images as AFO (Assault on Federal Officer) #527 Valuable assistance was provided by the U.S Capitol Police and the Metropolitan Police Department             In the 45 months since Jan more than 1,532 individuals have been charged in nearly all 50 states for crimes related to the breach of the U.S including more than 571 individuals charged with assaulting or impeding law enforcement             Anyone with tips can call 1-800-CALL-FBI (800-225-5324) or visit tips.fbi.gov             An indictment is merely an allegation and all defendants are presumed innocent until proven guilty beyond a reasonable doubt in a court of law.Attachment « Back Here at PUCRS you can take the course you want Courses that will make a difference in your development There are 20 program options in the best graduate courses in the country Renowned teachers and our quality guarantee Courses with different themes and prices for senior citizens Commitment to scientific and technological advancement.   Seeking solutions to the problems of our society.  Contributing to the training of specialists and researchers.   Be one of our researchers and contribute to scientific advancement We value ethics and integrity in our work.   Follow our guidelines for research and laboratory safety Scientific journals available exclusively in electronic media Discover an innovative and entrepreneurial university Discover the connected and global innovation ecosystem Discover the possibilities of an entrepreneurial education We facilitate your search for health and longevity Discover the school with the best medicine course in the country Ensuring an improvement in quality of life is our purpose Our biggest concern is people's health and lives Discover what PUCRS can do for you.    Prioritizing your development and well-being.   Tailored services for whatever your organization needs Cultural and well-being programming.   Contributing to the development of society.   Valuing your learning and talent development.   Hold your event in the most complete complex in the south of the country.   Services and environments that can make your day-to-day life easier Our impactful actions for the community and education Raising funds to finance projects and strategic actions We continue to work alongside the people of Rio Grande do Sul in rebuilding the State We are a community university focused on society A new University for a new society.   We are the best private university in the country and one of the best in the world the objective was to share the legacy left by Nico While the collection donated to the University was on display discussion groups and readings of some of the works of the writer and presenter from Rio Grande do Sul captivated the public The conversation about Nico's trajectory was led by Professor Ricardo, the Pro-Rector of Extension and Community Affairs Brother Manuir Mentges, from the representative of the publisher Gazeta Romar Rudolfo Beling and Ana Piagetti Fagundes it is very important that PUCRS be the custodian of the collection “We are very proud and committed to preserving Nico's memory,” he said Ana Piagetti said that her husband always wanted to donate the collection to a renowned university it brings together eight short stories written throughout the author's career Check out some photos from the event below Learn about research projects and our researchers information and follow everything that is happening at the University learn about the Fluir program and have access to the main systems The family of Joe Fagundes will tell you he was no “average Joe.” A devoted family man a staunch community supporter and a mischievous jokester are all apt descriptors for him there’s one more to add to the list — grand marshal Fagundes was selected as the Turlock Downtown Independence Day parade grand marshal His two daughters and three granddaughters will be riding in the parade in his memory the director for the Turlock Downtown Property Owner’s Association said Fagundes was told in 2023 that he had been selected as the grand marshal for the parade and that he was very excited about it “Joe was a shining example of what it means to go above and beyond for your community,” Regalo said He had a real desire to help people and created these events to bring people together.” Fagundes and his family moved to Turlock when he was 10 years old and he graduated from Turlock High in 1963 having already made a name for himself on the track and football field and the frequent visits to Principal John H regularly attending Friday night football games by serving on the selection committee to induct former athletes to the Turlock High School Hall of Fame and by being a member of the Turlock Quarterback Club It also was during high school that Fagundes became a member of the Ports Auto Club which held fundraisers to help sick children Old cars and charitable giving would become hallmarks of Fagundes’ life Fagundes attended barber school and became a licensed barber in 1964 His clients would sit down in his chair for a shave and cut and plenty of laughs He joined the Turlock Junior Chamber of Commerce and continued in this profession until being drafted into the U.S Fagundes served in Vietnam in 1967-68 in the First Infantry Division and received a National Defense Service Medal an Army Commendation Medal and a Bronze Star Upon his honorable discharge from the army Fagundes returned to Turlock in 1968 and resumed his occupation as a barber until 1971 when he decided to make a career change and launched a dairy business Fagundes loved the Turlock community and took every opportunity to serve the people of it He was a director and coach for Turlock Youth Football for 24 years and was awarded the Turlock Chamber of Commerce “Best of Turlock” Youth Involvement Award He also was a director and a member of the Turlock Historical Society Many in Turlock knew Fagundes through Fava Bean Day an annual celebration that was spun out of a lie Fagundes created “It was a joke that grew into something bigger,” Fagundes was fond of saying about his creation Fagundes was sautéing up a batch of beans at his ranch shop and on a whim told his workers and a friend that May 9 was Fava Bean Day in Portugal The Fava Bean Day cook-out that first year was so well-enjoyed by those few attendees that the following year a friend asked Fagundes if he would be cooking up another pot to celebrate the day so I asked him what he was talking about,” Fagundes previously told the Journal “It was then that he knew he had fallen for another joke.” but for many people May 9 was irrevocably known as Fava Bean Day Not only was it a day for them to get together and enjoy heaping bowls of fava beans and linguica it was a day to help children in the community From the early days of when a hundred or so people would come to Fagundes’ Turlock ranch for a fava bean dinner Fagundes saw the potential to turn his joke into a charitable force Every year the celebration collected donations that were then given to two or three children in the community that were diagnosed with cancer Over the years the grassroots effort collected well over $300,000 for local families the Freedoms Foundation at Valley Forge recognized his contributions to Fava Day Kids by awarding him the George Washington Honor Medal “He never expected nor wanted recognition for the things he did,” said Fagundes’ wife “He believed that you helped people because that is what your heart called you to do.” “He was a very patriotic man and felt strongly about what it meant to be an American,” said Yvette Fagundes-Hall, his daughter. Fagundes’ daughters, Fagundes-Hall and Theresa Fagundes-Diener along with his three granddaughters, Susannah Hall, Lillian Hall, and Rose Diener will be riding in the grand marshal car in his honor. Turlock’s annual Fourth of July parade — which will be at night for the first time ever — will start at 6:30 p.m. Friday.  Following the parade, at 9 p.m., will be a drone show. The annual car show will be held from 8 a.m. to 1 p.m. Saturday in downtown Turlock. The element requested is either not valid or does not exist. Log in for full access to stabroeknews.com. You can also post comments, and manage your email subscription. Only one active session is allowed per subscriber. A FREE roundup of top news from Guyana you might otherwise miss. Delivered every morning. Volume 9 - 2021 | https://doi.org/10.3389/fcell.2021.774845 This article is part of the Research TopicGenome Instability: Old Problem, New SolutionsView all 12 articles DNA replication must be precisely controlled in order to maintain genome stability Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits CCNE1 and CCNE2 genes) associate with CDK2 to promote G1/S transition Cyclin E/CDK2 complex mostly controls cell cycle progression and DNA replication through phosphorylation of specific substrates Oncogenic activation of Cyclin E/CDK2 complex impairs normal DNA replication Cyclin E/CDK2-induced replication stress leads to genomic instability and contributes to human carcinogenesis we focus on the main functions of Cyclin E/CDK2 complex in normal DNA replication and the molecular mechanisms by which oncogenic activation of Cyclin E/CDK2 causes replication stress and genomic instability in human cancer Regulation of E-type cyclins and the effects of Cyclin E/CDK2 complex in normal physiology and disease states have been extensively reviewed in the literature (Hwang and Clurman, 2005; Caldon and Musgrove, 2010; Siu et al., 2012; Chu et al., 2021) we focus on the role of Cyclin E/CDK2 complex in DNA replication and the molecular mechanisms by which hyperactivation of Cyclin E/CDK2 complex causes DNA replication stress and genomic instability in human cancer Cyclin E structure and function in the cell cycle (A) Schematic representation of Cyclin E1 and Cyclin E2 protein structures (B) Left: Cyclin E/CDK2 complex controls G1/S phase transition and S phase progression Heat map indicates Cyclin E/CDK2 complex activity through the cell cycle Right: Cyclin E/CDK2 complex regulates different cell cycle-related events and substrates we will focus on the functions of Cyclin E/CDK2 complex in normal and aberrant DNA replication Cyclin E/CDK2 complex directly interacts with (orange dashed lines) and phosphorylates (black arrows; P phosphate) several proteins that are essential for DNA replication Cyclin E/CDK2 activity inhibits pre-replication complex (pre-RC) formation (red arrow) and stimulates pre-initiation complex (pre-IC) formation (green arrow) DNA replication origins (Origin) are recognized by different proteins which are sequentially recruited to form pre-RC including ORC1-6 and MCM2-7 complexes (left beige circle) many other proteins are assembled onto DNA replication origins to form pre-IC including TOPBP1/RECQL4/Treslin and CDC45/GINS (right beige circle) Chromatin licensing and DNA replication factor 1; CDK DNA topoisomerase II binding protein 1; RECQL4 Numerous replisome proteins are omitted for simplicity Additional reports have suggested that Cyclin E/CDK2 complex is able to phosphorylate other proteins that constitute pre-RCs possibly interfering with chromatin loading or protein-protein interaction further definitive work is still necessary to clearly demonstrate and elucidate the effects of Cyclin E/CDK2-mediated phosphorylation of other pre-RC components in human cells One possible explanation is that oncogenic Cyclin E1/CDK2 activity forces rapid progression through G1 and premature entry into S phase with insufficient pre-RC formation the molecular mechanism by which hyperactive Cyclin E/CDK2 complex interferes with MCM loading and/or distribution onto chromatin is still not understood Molecular mechanisms of Cyclin E/CDK2-induced replication stress Oncogenic activation of Cyclin E/CDK2 interferes with DNA replication through several different molecular mechanisms Hyperactive Cyclin E/CDK2 complex impairs origin licensing by interference with pre-replication complex (pre-RC) loading onto chromatin (upper left) and origin firing by either decreasing or increasing activation of DNA replication origins (lower left; upper or lower DNA molecule Hyperactive Cyclin E/CDK2 complex also leads to insufficient nucleotide pools by forcing cell hyperproliferation without accompanying nucleotide biosynthesis (upper right) hyperactive Cyclin E/CDK2 complex causes transcription-replication collisions due to imbalances in DNA replication and gene transcription processes (lower right) Upper left: DNA molecule (blue double strand); ORC complex (green); CDC6 (purple); MCM complex (yellow); CDT1 (blue); Faded MCM complex represents impaired origin licensing Lower left: DNA molecule (blue double strand); DNA replication origins (Origin yellow double strand); Activated origin firing (green check); Impaired origin firing (stop signal) Upper right: chemical structures represent different nucleotides (blue) Lower right: DNA molecule (blue double strand); messenger RNA (yellow single strand); RNA polymerase (light green); MCM complex (yellow); R-loop (RNA-DNA hybrid molecule) Blue arrows indicate direction of transcription and replication progression the molecular mechanisms for disturbed origin firing upon oncogenic Cyclin E/CDK2 activation remain to be determined hyperactivation of Cyclin E/CDK2 complex clearly interferes with normal DNA replication causing replication stress and contributing to genomic instability these data indicate that oncogenic activation of Cyclin E/CDK2 complex drives numerous forms of genomic instability in human cancers ranging from whole chromosomal gains and/or losses to focal genomic deletions and/or amplifications The results suggest that further activation of CDK1 is not compatible with oncogenic Cyclin E/CDK2 environments leading to unscheduled mitotic entry and genome instability these data indicate that cancer subtypes with oncogenic activation of Cyclin E/CDK2 complex and subsequent robust activation of RSR may be especially vulnerable and uniquely sensitive to inhibitors of replication checkpoint proteins Exploiting these therapeutic opportunities will certainly prove beneficial to cancer treatment in the following years RF and LT designed and wrote the manuscript Both authors approved the submitted version Work in the LT laboratory was supported by grants from CNPq (307.449/2020-3) and FAPERJ (002.586/2019) to LT The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher We apologize to authors whose work has not been cited due to space constraints We thank Sapiens Scientific Illustrations for figure preparation Work in the LT laboratory was supported by grants from Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) RF was supported by a fellowship from the Brazilian National Cancer Institute (INCA) Identification of a Cyclin-Cdk2 Recognition Motif Present in Substrates and P21-like Cyclin-dependent Kinase Inhibitors PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Histone Acetyltransferase Activity of CBP Is Controlled by Cycle-dependent Kinases and Oncoprotein E1A PubMed Abstract | CrossRef Full Text | Google Scholar Cdc2-cyclin E Complexes Regulate the G1/S Phase Transition PubMed Abstract | CrossRef Full Text | Google Scholar Dynamics of DNA Replication in Mammalian Somatic Cells PubMed Abstract | CrossRef Full Text | Google Scholar DNA Damage Response as a Candidate Anti-cancer Barrier in Early Human Tumorigenesis PubMed Abstract | CrossRef Full Text | Google Scholar Oncogene-induced Senescence Is Part of the Tumorigenesis Barrier Imposed by DNA Damage Checkpoints PubMed Abstract | CrossRef Full Text | Google Scholar Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases PubMed Abstract | CrossRef Full Text | Google Scholar Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development PubMed Abstract | CrossRef Full Text | Google Scholar Signatures of Mutation and Selection in the Cancer Genome PubMed Abstract | CrossRef Full Text | Google Scholar Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Distinct and Redundant Functions of Cyclin E1 and Cyclin E2 in Development and Cancer PubMed Abstract | CrossRef Full Text | Google Scholar Low-molecular-weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin-binding Motifs Are Essential for the Function of p21CIP1 PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition PubMed Abstract | CrossRef Full Text | Google Scholar Regulates Centrosome Duplication in Human Cells PubMed Abstract | CrossRef Full Text | Google Scholar A Novel Landscape of Nuclear Human CDK2 Substrates Revealed by In Situ Phosphorylation PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E in normal Physiology and Disease States PubMed Abstract | CrossRef Full Text | Google Scholar Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry PubMed Abstract | CrossRef Full Text | Google Scholar Turnover of Cyclin E by the Ubiquitin-Proteasome Pathway Is Regulated by Cdk2 Binding and Cyclin Phosphorylation PubMed Abstract | CrossRef Full Text | Google Scholar Analysis of Cdc6 Function in the Assembly of Mammalian Prereplication Complexes PubMed Abstract | CrossRef Full Text | Google Scholar Break-induced Replication Repair of Damaged forks Induces Genomic Duplications in Human Cells PubMed Abstract | CrossRef Full Text | Google Scholar Distinct Roles for Cyclins E and A during DNA Replication Complex Assembly and Activation PubMed Abstract | CrossRef Full Text | Google Scholar Physical Interaction of the Retinoblastoma Protein with Human D Cyclins PubMed Abstract | CrossRef Full Text | Google Scholar Association of Human Cyclin E with a Periodic G1-S Phase Protein Kinase PubMed Abstract | CrossRef Full Text | Google Scholar Deregulation of Cyclin E in Human Cells Interferes with Prereplication Complex Assembly CrossRef Full Text | Google Scholar The Mouse Mps1p-like Kinase Regulates Centrosome Duplication PubMed Abstract | CrossRef Full Text | Google Scholar DNA Replication Origin Activation in Space and Time PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E Uses Cdc6 as a Chromatin-Associated Receptor Required for DNA Replication CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar CCNE1 Amplification Is Synthetic-Lethal with PKMYT1 Kinase Inhibition CrossRef Full Text | Google Scholar Regulation of Cyclin E Transcription by E2Fs and Retinoblastoma Protein PubMed Abstract | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar A Role for E2F6 in Distinguishing G1/S- and G2/M-specific Transcription PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-specific Copy Number Alterations PubMed Abstract | CrossRef Full Text | Google Scholar Causes and Consequences of Centrosome Abnormalities in Cancer PubMed Abstract | CrossRef Full Text | Google Scholar a Novel G 1 Cyclin that Binds Cdk2 and Is Aberrantly Expressed in Human Cancers PubMed Abstract | CrossRef Full Text | Google Scholar the Human Homologue of Yeast Hir1p and Hir2p Is a Novel Cyclin-Cdk2 Substrate Whose Expression Blocks S-phase Progression PubMed Abstract | CrossRef Full Text | Google Scholar The Rb/E2F Pathway: Expanding Roles and Emerging Paradigms PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar The Structure of Cyclin E1/CDK2: Implications for CDK2 Activation and CDK2-independent Roles PubMed Abstract | CrossRef Full Text | Google Scholar Short Protein Binding Motifs in ORC1 and CDC6 Control the Initiation of DNA Replication PubMed Abstract | CrossRef Full Text | Google Scholar Opposing Roles for DNA Replication Initiator Proteins ORC1 and CDC6 in Control of Cyclin E Gene Transcription PubMed Abstract | CrossRef Full Text | Google Scholar E2F-dependent Accumulation of hEmi1 Regulates S Phase Entry by Inhibiting APCCdh1 PubMed Abstract | CrossRef Full Text | Google Scholar Essential Role for Cdk2 Inhibitory Phosphorylation during Replication Stress Revealed by a Human Cdk2 Knockin Mutation PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E in normal and Neoplastic Cell Cycles PubMed Abstract | CrossRef Full Text | Google Scholar Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin A- and Cyclin E-Cdk Complexes Shuttle between the Nucleus and the Cytoplasm PubMed Abstract | CrossRef Full Text | Google Scholar Increased Replication Initiation and Conflicts with Transcription Underlie Cyclin E-Induced Replication Stress PubMed Abstract | CrossRef Full Text | Google Scholar Induction of Centrosome Amplification and Chromosome Instability in Human Bladder Cancer Cells by P53 Mutation and Cyclin E Overexpression PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E Overexpression Impairs Progression through Mitosis by Inhibiting APCCdh1 CrossRef Full Text | Google Scholar Identification of a Substrate-Targeting Domain in Cyclin E Necessary for Phosphorylation of the Retinoblastoma Protein PubMed Abstract | CrossRef Full Text | Google Scholar Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase PubMed Abstract | CrossRef Full Text | Google Scholar a New Cyclin that Interacts with Two Members of the CDC2 Gene Family PubMed Abstract | CrossRef Full Text | Google Scholar Formation and Activation of a Cyclin E-Cdk2 Complex during the G 1 Phase of the Human Cell Cycle PubMed Abstract | CrossRef Full Text | Google Scholar Overexpression of Cyclin E1 or Cdc25A Leads to Replication Stress and Increased Sensitivity to Replication Checkpoint Inhibitors PubMed Abstract | CrossRef Full Text | Google Scholar Direct Regulation of Treslin by Cyclin-dependent Kinase Is Essential for the Onset of DNA Replication CrossRef Full Text | Google Scholar Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication PubMed Abstract | CrossRef Full Text | Google Scholar Regulation of Mammalian Nucleotide Metabolism and Biosynthesis PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E2: a Novel CDK2 Partner in the Late G1 and S Phases of the Mammalian Cell Cycle PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer PubMed Abstract | CrossRef Full Text | Google Scholar Isolation of Three Novel Human Cyclins by rescue of G1 Cyclin (Cln) Function in Yeast PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin-dependent Kinase Subunit (Cks) 1 or Cks2 Overexpression Overrides the DNA Damage Response Barrier Triggered by Activated Oncoproteins PubMed Abstract | CrossRef Full Text | Google Scholar Cell Cycle-dependent Phosphorylation Regulates RECQL4 Pathway Choice and Ubiquitination in DNA Double-Strand Break Repair PubMed Abstract | CrossRef Full Text | Google Scholar Cell Cycle-Regulated Phosphorylation of p220NPAT by Cyclin E/Cdk2 in Cajal Bodies Promotes Histone Gene Transcription PubMed Abstract | CrossRef Full Text | Google Scholar Intragenic Origins Due to Short G1 Phases Underlie Oncogene-Induced DNA Replication Stress PubMed Abstract | CrossRef Full Text | Google Scholar CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-dependent Proteolysis PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Eukaryotic Chromosome DNA Replication: where PubMed Abstract | CrossRef Full Text | Google Scholar A Centrosomal Localization Signal in Cyclin E Required for Cdk2-independent S Phase Entry PubMed Abstract | CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar The Tandem Duplicator Phenotype Is a Prevalent Genome-wide Cancer Configuration Driven by Distinct Gene Mutations PubMed Abstract | CrossRef Full Text | Google Scholar Oncogenes Create a Unique Landscape of Fragile Sites PubMed Abstract | CrossRef Full Text | Google Scholar Identification of the Nuclear Localization Signal inXenopusCyclin E and Analysis of its Role in Replication and Mitosis PubMed Abstract | CrossRef Full Text | Google Scholar Regulation of E2F Transcription by Cyclin E-Cdk2 Kinase Mediated through P300/CBP Co-activators PubMed Abstract | CrossRef Full Text | Google Scholar Exploiting Oncogene-Induced Replicative Stress for the Selective Killing of Myc-Driven Tumors PubMed Abstract | CrossRef Full Text | Google Scholar Synergistic Induction of Centrosome Hyperamplification by Loss of P53 and Cyclin E Overexpression PubMed Abstract | CrossRef Full Text | Google Scholar Oncogenes Induce Genotoxic Stress by Mitotic Processing of Unusual Replication Intermediates CrossRef Full Text | Google Scholar Genomic Instability - an Evolving Hallmark of Cancer PubMed Abstract | CrossRef Full Text | Google Scholar Targeting the Replication Stress Response through Synthetic Lethal Strategies in Cancer Medicine PubMed Abstract | CrossRef Full Text | Google Scholar Proteomic Landscape of Tissue-specific Cyclin E Functions In Vivo PubMed Abstract | CrossRef Full Text | Google Scholar Regulation of the Cyclin E Gene by Transcription Factor E2F1 PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin-Dependent Regulation of G 1 in Mammalian Fibroblasts PubMed Abstract | CrossRef Full Text | Google Scholar Nucleophosmin/B23 Is a Target of CDK2/cyclin E in Centrosome Duplication PubMed Abstract | CrossRef Full Text | Google Scholar Cell Cycle Proteins as Promising Targets in Cancer Therapy PubMed Abstract | CrossRef Full Text | Google Scholar Quantitative Proteomics Reveals the Basis for the Biochemical Specificity of the Cell-Cycle Machinery PubMed Abstract | CrossRef Full Text | Google Scholar Cyclins E1 and E2 Are Required for Endoreplication in Placental Trophoblast Giant Cells PubMed Abstract | CrossRef Full Text | Google Scholar E2Fs Up-Regulate Expression of Genes Involved in DNA Replication PubMed Abstract | CrossRef Full Text | Google Scholar DNA Replication Stress: Oncogenes in the Spotlight PubMed Abstract | CrossRef Full Text | Google Scholar Inactivation of hCDC4 Can Cause Chromosomal Instability PubMed Abstract | CrossRef Full Text | Google Scholar Acceleration of the G1/S Phase Transition by Expression of Cyclins D1 and E with an Inducible System PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin-dependent Kinase Regulates the Length of S Phase through TICRR/TRESLIN Phosphorylation PubMed Abstract | CrossRef Full Text | Google Scholar Substrate Recruitment to Cyclin-dependent Kinase 2 by a Multipurpose Docking Site on Cyclin A PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Living with or without Cyclins and Cyclin-dependent Kinases PubMed Abstract | CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar An Integrated View of Cyclin E Function and Regulation PubMed Abstract | CrossRef Full Text | Google Scholar Deregulated Cyclin E Induces Chromosome Instability PubMed Abstract | CrossRef Full Text | Google Scholar Human F-Box Protein hCdc4 Targets Cyclin E for Proteolysis and Is Mutated in a Breast Cancer Cell Line PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε PubMed Abstract | CrossRef Full Text | Google Scholar Targeting CDK2 in Cancer: Challenges and Opportunities for Therapy PubMed Abstract | CrossRef Full Text | Google Scholar FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A PubMed Abstract | CrossRef Full Text | Google Scholar Helicase Activation and Establishment of Replication forks at Chromosomal Origins of Replication PubMed Abstract | CrossRef Full Text | Google Scholar Deregulated G1-Cyclin Expression Induces Genomic Instability by Preventing Efficient Pre-RC Formation PubMed Abstract | CrossRef Full Text | Google Scholar CDK-dependent Phosphorylation of Sld2 and Sld3 Initiates DNA Replication in Budding Yeast PubMed Abstract | CrossRef Full Text | Google Scholar “Cyclin E Deregulation and Genomic Instability,” in DNA Replication PubMed Abstract | CrossRef Full Text | Google Scholar Cyclin E Deregulation Promotes Loss of Specific Genomic Regions PubMed Abstract | CrossRef Full Text | Google Scholar Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover PubMed Abstract | CrossRef Full Text | Google Scholar Specific Phosphorylation of Nucleophosmin on Thr199 by Cyclin- Dependent Kinase 2-Cyclin E and its Role in Centrosome Duplication CrossRef Full Text | Google Scholar A Cell-Based Screen Identifies ATR Inhibitors with Synthetic Lethal Properties for Cancer-Associated Mutations PubMed Abstract | CrossRef Full Text | Google Scholar Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation PubMed Abstract | CrossRef Full Text | Google Scholar E2F7 Represses a Network of Oscillating Cell Cycle Genes to Control S-phase Progression PubMed Abstract | CrossRef Full Text | Google Scholar Activation of Cyclin E/CDK2 Is Coupled to Site-specific Autophosphorylation and Ubiquitin-dependent Degradation of Cyclin E PubMed Abstract | CrossRef Full Text | Google Scholar Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase CrossRef Full Text | Google Scholar Pan-cancer Patterns of Somatic Copy Number Alteration PubMed Abstract | CrossRef Full Text | Google Scholar a Novel Human G1 Cyclin and Activating Partner of CDK2 and CDK3 PubMed Abstract | CrossRef Full Text | Google Scholar Phosphorylation of Sld2 and Sld3 by Cyclin-dependent Kinases Promotes DNA Replication in Budding Yeast PubMed Abstract | CrossRef Full Text | Google Scholar Loss of Cyclin-dependent Kinase 2 (CDK2) Inhibitory Phosphorylation in a CDK2AF Knock-In Mouse Causes Misregulation of DNA Replication and Centrosome Duplication PubMed Abstract | CrossRef Full Text | Google Scholar NPAT Links Cyclin E-Cdk2 to the Regulation of Replication-dependent Histone Gene Transcription PubMed Abstract | CrossRef Full Text | Google Scholar Citation: Fagundes R and Teixeira LK (2021) Cyclin E/CDK2: DNA Replication Replication Stress and Genomic Instability Received: 13 September 2021; Accepted: 28 October 2021;Published: 24 November 2021 Copyright © 2021 Fagundes and Teixeira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Leonardo K. Teixeira, bGt0ZWl4ZWlyYUBpbmNhLmdvdi5icg== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish was arrested on 24-07-2024 and charged yesterday with the offences of: 1) Possession of fire-arms without a licence; 2) Possession of ammunition without a licence The accused appeared at the Georgetown Magis-trate’s Court #3 before Magistrate Clive Nurse Fagundes was arrested during a Police intelligence-led operation which was conducted at about 5.30 am on Wednesday A total of 26 handguns and high-powered rifles Fagundes was seen exiting the door of a flat wooden house in the yard with a side bag in his right hand and a search was carried out in the bag and one Sig Sauer Rifle and one magazine containing fourteen 9mm rounds of ammunition one Polimore-80 9mm pistol without serial number and one magazine containing eight 9mm rounds of ammunition one Spring Field Armory 45 pistol and four magazines one containing five live .45 rounds of ammunition ** One AM 15 rifle and two magazines containing sixty-one .223 rounds of ammunition ** Two Ruger-57 9mm pistols and one magazine containing forty rounds of 9mm ammunition ** One FN-45 pistol and two magazines containing thirty-eight rounds of .45 ammunition ** One Smith and Wesson 9mm pistol and one magazine ** One Berretta 9mm pistol and one  magazine ** One Spring Field Hellcat 9mm pistol and one magazine nine  Magazines and twenty-one  rounds of 9mm ammunition ** Seven Glock 40 pistols and ten magazines with eighteen rounds of .40 ammunition ** Two Glock 17 9mm pistols and two magazines ** Four hundred and fifty-six rounds of .223 ammunition ** Four hundred and eighty-four  rounds of 9mm ammunition ** Eighty-three rounds of 5.7- 28 ammunition ** Three hundred and fifteen  rounds of 7.62 -39 ammunition and No charges have been reported against them It’s no secret that the caregivers of spouses with memory impairment face enormous amounts of stress Researchers at Rice University have found that this intense pressure can be felt at the cellular level and is linked to negative physical and mental health effects including dementia and Alzheimer’s disease “We are very happy and satisfied to have Nico’s works and on behalf of all the people of Rio Grande do Sul who will have access to this material,” Clotet said His widow Ana Lúcia Piagetti Fagundes spoke emotionally about Nico Fagundes’ concern for the future of his collection I am very happy that his collection will prosper because it would not be fair to leave the books just decorating the walls,” she said highlighting the future digitalization of the works His nephew Ernesto Fagundes said that the donation of the material to PUCRS is “one of his uncle’s greatest victories” and recited an excerpt from the song Sources because he believed that he was describing the moment: “I know that I will not die because the world that I built will remain with me Antonio Augusto Fagundes passed away in June 2015 he worked as a columnist and reporter at Gazeta do Alegrete and Rádio Alegrete where he presented humorous and gaucho programs he worked at the newspaper the hour and on TV Piratini He was known for presenting the program Creole Shed Nico is the author of the lyrics Alegretense Corner one of the most well-known songs of the state specialized in the History of Rio Grande do Sul and completed a Master's in Social Anthropology identity and customs of the state and transformed what he discovered into books and songs Continuing to browse our website indicates your consent to our use of cookies. For more information, see our Privacy policy. Current Accounts: The Hinrich Foundation Trade Podcast Tune in to this special episode hosted by the Association of Foreign Press Correspondents in the United States here: Amid efforts to promote sustainability through trade has unilaterally launched the Renewable Energy Directive (RED) and the EU Deforestation Regulation (EUDR) to help the single market achieve its ambitious climate goals by 2030 several countries have established or plan to adopt private standards and certifications to ensure compliance with these new regulations the results of adopting these voluntary standards have been mixed While the country’s exports of sugar and ethanol to Europe have generally increased these gains are often limited to municipalities with established trade ties with the EU areas with fewer prior trade ties have seen declining exports compliance with these standards may inadvertently lead to land concentration favoring larger agricultural units and potentially exacerbating land inequality within Brazil They also discuss the heterogeneous effect and history of trade across Brazilian municipalities The research highlights the role of policymakers in developed nations can mitigate adverse spillover effects to achieve their sustainability goals Download Full Transcript At the end of this research in which you explore the socioeconomics spillovers of private sugar certification that complements an EU unilateral trade policy what have you found about the socioeconomic spillovers These three fronts that are under constant development But what we have so far are three findings this connection between private and binding trade and sustainability requirements which is precisely what the work that we’re talking about deals with Some people might say that this is not a form of disguised protection because it actually increases exports to the European Union meaning that the positive results are centered on the cities that are the most productive cities which are also the ones that have the largest players If you take the municipalities that traditionally export less to the European Union when they get the certification to comply with the biofuel laws from the European Union They either stop exporting to the European Union at all and export to other countries or they sell their production to traders so that those traders can export to the European Union Tune into the Hinrich Foundation’s podcast series for insights on international trade Listen to the podcast © The Hinrich Foundation. See our website Terms and conditions for our copyright and reprint policy conclusions and recommendations expressed in this publication are the sole responsibility of the author(s) Articles by this expert View bio Rodrigo Fagundes Cezar is a professor at Fundação Getulio Vargas (FGV) School of International Relations in São Paulo Articles by this expert View bio Subscribe to our weekly newsletter for global trade insights and articles Receive our trade insights and information about programs Our latest newsletter Hinrich Foundation is an Asia-based philanthropic organization that works to advance mutually beneficial and sustainable global trade We believe sustainable global trade strengthens relationships between nations and improves people’s lives We support original research and education programs that build understanding and leadership in global trade inquiry@hinrichfoundation.com A police operation yesterday found a large cache of arms at the Kitty home of the murdered Ricardo Fagundes and six persons are in custody The startling find will raise questions about how long the arsenal was in existence and its use It will also deepen the mystery around the yet unsolved murder of Fagundes known as `Paper Shorts’ outside the Palm Court Restaurant and Bar in March 2021 Six persons were arrested and are in custody Eon Fagundes was seen exiting the door of a flat wooden house in the yard with a side bag in his right hand The police say that Fagundes was asked if he was the holder of a firearm licence to carry the said firearms and he said ‘no’ A further search was carried out in the house A black Nissan Juke vehicle (Registration number PVV 6472) was parked on Sandy Babb Street’s southern side The police say that Fagundes was asked who owned the car and he said his daughter and the mother of his child and a search was then carried out in his presence and the following firearms ammunition and magazines were found in a  suitcase ** One AM 15 rifle and two magazines containing sixty-one rounds of .223 ammunition ** One Berretta 9mm pistol and one magazine nine Magazines and twenty-one rounds of 9mm ammunition ** Seven Glock 40 pistols and ten magazines  with eighteen  rounds of 40 ammunition The police say they also found in the bags and suitcase: ** Four hundred and fifty-six  rounds of .223 ammunition ** Four hundred and eighty-four rounds of  9mm ammunition ** Eighty-three rounds of  5.7- 28 ammunition ** Three hundred and fifteen rounds of 7.62 -39 ammunition and Fagundes was further told of the offences committed and cautioned A total of 26 handguns and high-powered rifles were found during the successful Police intelligence-led operation The following persons who were at the said address in the house at the time of the Police operation were all arrested for questioning ammunition and magazines were taken to the GPF’s Ballistic Section to be examined Ricardo Fagundes was riddled with bullets by two men outside of Palm Court around 10 pm on Sunday Fagundes was having drinks with a colleague in Palm Court when he received a call on his phone the police said several loud explosions were heard An autopsy later showed that Fagundes was shot about 20 times about his body while the other fourteen were from a 9mm-calibre gun During a speech at Fagundes’ funeral service convicted drug trafficker Roger Khan said that he was the real target of the shooting Khan had also been at Palm Court at the time Khan had appealed to President Irfaan Ali for a “clean and impartial” investigation I am asking you on behalf of the family of Ricardo to give this investigation the very same attention that you gave the Henry boys Ricardo’s life is no less important than any other life in Guyana that this investigation be handled by impartial investigators,” he pleaded He said the family will not rest until they receive justice if the police do not investigate this crime and follow the evidence rather than follow the money or any kind of corrupt motive the hearts of men will become enraged,” Khan stated the police in a statement had said that they were pursuing all leads to ensure that the perpetrators are brought to justice the police have not been forthcoming on how the investigation is progressing and whether they are making headway questions still linger about a number of aspects of the investigation This includes whether the police were able to ascertain the identity of Fagundes’ alleged shooters from security footage obtained and if they were able to determine the origin of the AK-47 assault rifle which was used in the shooting it is unclear whether investigators were able to determine if a vehicle found burnt at Swan Village on the Soesdyke-Linden Highway hours after the shooting was the same used in the crime the findings of ballistic tests from the spent shells and bullets recovered from the body remain unknown Matters took a dramatic turn in August of 2022 when  police detective Dion Bascom alleged that there had been a cover-up of the killing of Fagundes Superintendent of Police Mitchell Caesar and Mohamed’s Enterprise moved to refute and distance themselves from the bombshell corruption allegations made by Bascom the Deputy Head of the Guyana Police Force’s Major Crimes Unit demanded that Bascom retract allegations he made during a Facebook video and publicly apologise or face lawsuits The government later commissioned the Barbados-based Regional Security System (RSS) to investigate the corruption claims the Ministry of Home Affairs said that the  RSS did not find any evidence of corrupt practices or an attempt to cover up the probe into the  murder of Fagundes The RSS report was not released by the government instead the Ministry of Home Affairs prepared a  release purporting to present the findings of the investigation Observers had questioned from the onset of the RSS investigation how it would be possible to test Bascom’s claims unless it had spoken to him Bascom was not spoken to by the RSS investigator and his request to President Irfaan Ali for witness protection was not responded to historian and folklorist Antonio Augusto Fagundes he was a columnist and reporter for Gazeta do Alegrete and Rádio Alegrete he worked for the newspaper A Hora and TV Piratini Nico is the author of the lyrics for the Alegretense Corner identity and customs of the State and transformed what he discovered into books and songs Last Updated on Wednesday, 9 April 2025, 22:38 by Writer President Irfaan Ali on Tuesday denied a claim by his former close associate that two senior cabinet members had threatened to investigate him if he did not issue a statement stating that he was not entering politics who was sanctioned by the United States last year for allegedly evading US$50 million in taxes from Guyana on more than 10,000 kilograms of gold exports has hinted that he will be entering politics for the 2025 general and regional elections Mr Mohamed and his father Nazar “Shell” Mohamed have been complaining that they were being targeted by the police and the Guyana Revenue Authority (GRA) which had initially issued permission for the Mohameds’ foreign flagged tugs and barges to conduct coastal voyages Almost immediately after the sanctions had been issued against the Mohameds the Bank of Guyana revoked that business’ foreign exchange dealer’s “cambio” licence and financial institutions were ordered to cut ties with them for fear of infecting the banking system and exposing the country to further sanctions They said their licensed firearms have been taken away and the GRA has moved to impose more than GY$1.2 billion import duties on luxury and other vehicles that had already been cleared and duties paid for said it had “irrefutable evidence” for its actions and that there was a stack of evidence of going after vehicle owners who had violated the duty-free concessions for re-migrants and diplomats The Mohameds last weekend obtained an interim High Court order blocking GRA from seizing the vehicles pending the hearing and determination of a substantive case to quash the GRA’s efforts to charge additional duties During efforts last Saturday to seize the vehicles from the Mohameds residence Mr Azruddin alleged that Vice President Bharrat Jagdeo and Attorney General Anil Nandlall had called him threatening to take away the vehicles if he did not publicly state that he would not be getting into politics “Jagdeo and Nandlall told me that they’re coming to seize the vehicles if I don’t release a statement that I am not running for office,” he said Mr Nandlall said he was unaware that Mr Azruddin would be seeking elected office and bluntly denied speaking with the businessman in the presence of the Vice President “I have never spoken to Mr Azruddin Mohamed in the presence of Mr Jagdeo… Since the sanction was imposed I have never spoken to Mr Mohamed in person or on the telephone by himself,” he said “I met with the Mohameds a few times after the sanctions in order to explain to them that under the law the government would have to take certain measures and take certain precautionary steps to protect the financial system of Guyana and to protect the State against the pernicious consequences of the sanctions.” He said those “courteous and cordial” meetings were held in the presence of their team of lawyers and focussed on “disengaging seamlessly” from all government and State businesses He said at no time had the Mohameds complained of treating them unfairly or unlawfully Zooming in on Mr Azruddin’s specific allegation of blackmail “I had an opportunity to get an insight into the mentality of this guy when he fabricated such a naked untruth against myself and Mr Jagdeo.” He said the Vice President has also denied such a “barefaced” accusation and would address the claim at this week’s news conference Mr Nandlall on Tuesday night’s edition of “Issues In The News” said the GRA enjoys post-audit powers which was legally enforcing against the Mohameds even as he denied any political motive behind such an action between this exercise or in relation to this exercise,” he said But President Ali on Tuesday bluntly denied that those two senior members of his Cabinet had ever threatened to blackmail the businessmen Insisting that his administration was abiding by the law the Guyanese leader said the United States’ Federal Bureau of Investigations (FBI) was also continuing its investigations into the March 2021 gunning down of Ricardo “Paper Shorts” Fagundes outside Palm Court Shaheed “Roger” Khan had said then that the bullets were meant for him instead In addition to having the Caribbean Regional Security System (RSS) review files by local investigators President Ali said the FBI was now poised to provide more information “We then took an important piece of evidence and we sent that piece of evidence to the FBI there will be additional questioning that is required and that is a process I don’t get involved in that,” he said With Mr Azruddin attracting pockets of support from Guyanese across the racial divide who would be running for a second term in general elections slated for later this year dismissed questions on whether he was afraid of the businessman chipping away support from the governing People’s Progressive Party Civic (PPPC) Quizzed on why he was paying attention to him in his recent community public meetings “I’m not paying any attention to him While restating that he had known Mr Mohamed growing up as a child he said his administration’s consistent position was that action would be taken once there is evidence Now that the US has provided “important” information to the Guyana government about the alleged tax evasion by the Mohameds that would trigger certain actions nothing to do with political ambition,” he said The President challenged Mr Azruddin to “bring it on if you want to contest” the elections rather and join forces with the Alliance For Change (AFC) which he claimed had been organising the businessman’s meetings “We don’t have a problem with that That’s your right but we must be open and transparent about how we deploy our democratic right,” he said The PPPC presidential candidate again expressed confidence in winning this year’s general elections on the basis of hard work “We are not going to win this election because we are lazy We are going to win this election because we were democratic We are not going to win this election because we tried to steal an election,” he said a 58-year-old taxi driver from Fourth Avenue appeared in the Bartica Magistrate Court yesterday morning before Magistrate Tariq Mohamed where he pleaded guilty to three charges including being an unlicenced driver The police said in a release that Fagundes was charged with refusal of consent to take a breathalyzer test being an unlicensed driver and breach of insurance He pleaded guilty to all the charges and was fined $20,000 (or three months imprisonment) on the breathalyzer test $5000 for being an unlicenced driver (or two weeks imprisonment) and $25,000 for breach of insurance (or two weeks imprisonment) Please enable JS and disable any ad blocker He is the leader of FGV’s research group International Trade & Sustainability Rodrigo holds a summa cum lauda PhD in International Relations from the Geneva Graduate Institute He has appeared in multiple high-ranking academic journals and diffused his research via newspapers and op-eds in Brazil and internationally He is interested in the politics of trade and sustainability and in the political impact of firms in trade Rodrigo previously worked at the United Nations Development Programme (UNDP) in Brazil Amid the multiple pathways to promote sustainability through trade import policies have taken the center stage unilaterally launched the Renewable Energy Directive (RED) and the EU Deforestation Regulation (EUDR) in the hopes that these measures would help the single market reach its ambitious climate goals by 2030 several countries have established or plan to use private standards and certifications to assure compliance with these new regulations In this study, commissioned under the Hinrich Foundation Research Grant that funds up-and-coming academics, Rodrigo Cezar of Fundação Getulio Vargas School of International Relations and his team found that the adoption of VSS in Brazil has produced mixed results While the country’s exports of sugar and ethanol to Europe have increased overall such gains are often confined to municipalities with established trade ties with the EU the research suggests that policymakers in the Global North should address the negative spillover effect of unilateral green rules to ensure that sustainable trade policies reach their intended goals As the authors conclude with a list of recommendations for mitigating the externalities of climate governance they highlight the need to enhance community empowerment efforts in order to achieve the co-benefits of socioeconomic development and environmental protection Download Unilateral green rules and voluntary standards: A balancing act for Brazil by Rodrigo Fagundes Cezar Yixian Sun is a professor at the University of Bath and an Adjunct Senior Research Fellow at the Institute for Environment and Sustainability Articles by this expert View bio Guilherme De Franco holds a summa cum laude bachelor’s degree in International Relations from Fundação Getulio Vargas (FGV) School of International Relations Articles by this expert View bio Jordan and Iraqi airspace is temporarily closed after Iran’s biggest-ever missile attack on Israel .. Lufthansa Group’s cargo customers will see a rise in the carriers’ airfreight surcharge (ASC) from .. For aviation to reach net zero emissions is a real challenge – and the path .. Cutting emissions from aviation will cost hundreds of billions of dollars – and companies and .. The arms race among airlines in the lucrative and fast-growing pharma and life sciences sector .. Nestlé veteran Lorenzo Stoll (pictured) is set to become head of Swiss WorldCargo after Ashwin Bhat .. email: [email protected] email: [email protected] email: [email protected] email: [email protected] email: [email protected] Keith Fagundes has had a challenging term that culminated Tuesday night in his defeat in the Kings County District Attorney race.  Sarah Hacker received nearly 58% of the vote — 6,548 to Fagundes' 4,751 votes Because Hacker has more than 50% of the vote she wins the race and ends Fagundes' time as district attorney.  Hecker is an attorney with Dias Law Firm in Hanford She served as a Kings County deputy district attorney from 2006 to 2015 Hecker pledged to enforce the law on the streets and in the jail and seek out restitution orders so that victims would be compensated for their losses "I want to extend my thanks to all Hacker Backers There were people who went all out and supported me openly and passionately And then there were those who I did not know who assisted too," she wrote on social media. "Thank you all We all stand strong and proud to bring Justice for All." Hacker has spoke out against Fagundes' decision to prosecute two Kings County mothers, Adora Perez and Chelsea Becker.  California's November ballot takes shape: Newsom vs. Dahle for governor, Padilla vs. Meuser for Senate "The goal of the district attorney’s office is to ensure the cases are prosecuted with integrity," her candidate statement read. "As your district attorney I will focus on fairly and justly prosecuting cases."  The women struggled with addiction and delivered stillborn babies who tested positive for methamphetamine at Adventist Health hospital in the Kings County Fagundes later filed charges that were eventually thrown out but not before the women spent years behind bars.  Attorney General Rob Bonta later advised counties that the fetal murder cases were an attack on pregnant mothers. Former AG Xavier Becerra also argued that Fagundes "misapplied and misinterpreted" the law when he charged one of the mothers "Section 187 of the California Penal Code was intended to protect pregnant women from harm not charge them with murder," the state's top law enforcement officer said in a 2020 news release. "Our laws in California do not convict women who suffer the loss of their pregnancy, and in our filing today we are making clear that this law has been misused to the detriment of women Fagundes stood by his decision to prosecute the cases stating that someone needs to be a voice for the fetus.   Related: California Democrats look to add abortion-protection amendment to November 2022 ballot Fagundes faced another hurdle when a lawsuit was filed by former Kings County District Attorney Chief Investigator Robert Waggle.  Fagundes started making unwanted advances toward Waggle described as a "heterosexual male," in 2018. When the employee rebuffed Fagundes the district attorney started to retaliate Fagundes disputes all allegations made in the claim and said it is "riddled with falsities." "It's shocking and surprising he's taking this position," Fagundes said during a 2021 interview with the Times-Delta "It is what it is at the end of the day."  Fagundes was elected as Kings County district attorney in 2014 and sworn in for his second term in 2019 with 71% of the vote Fagundes posted to his campaign Facebook page thanking his campaign team.  I am very proud of our team who has not stooped to the negative campaign tactics that include spreading false and misleading information that our opponent has used," he stated Fagundes was not the only district attorney to lose his seat on Tuesday in a major shift statewide.  San Francisco District Attorney Chesa Boudin was recalled with 60% of voters in favor of removing him Los Angeles District Attorney George Gascon faced the threat of a recall but The Recall George Gascon campaign failed to gather enough signatures to place the recall vote on November's ballot.  appears to have lost by double digits to Nicole Silveira Silveira is a supervising prosecutor in Lewis' office The DA was down 30 points at one time Tuesday night Diane Kelley announced that she would not be seeking re-election later this year Kelley says she was recently offered an opportunity to work for HOPE Squad an organization that she has volunteered with for nearly 3 years On Friday, realtor Joe Fagundes announced his candidacy for the District 5 seat […] Last week, Okaloosa School Board Member Dr. Diane Kelley announced that she would not be seeking re-election later this year On Friday, realtor Joe Fagundes announced his candidacy for the District 5 seat that represents the Niceville/Bluewater Bay and Eglin Air Force Base schools “This decision has been in the making for several years and I would like to thank our current School Board member Diane Kelley for her many years of service to the School District and most recently as the District 5 School Board member,” said Fagundes.  Fagundes has served in the Niceville area as a member of both the Niceville High School and Ruckel Middle School School Advisory Council for the last 12 years He also has served as a North Bay Fire Control District commissioner for the last 8 years Join the best local newsletter read by thousands of locals each weekday morning Be sure you have your GPS enabled and try again New and returning coach has potentially strong team I wrote a piece on the sudden departure of St Vincent girls basketball coach Jim Fagundes The highly successful mentor (97-51) had mutually agreed with the St Vincent administration to step aside after leading his teams to a couple of North Central League II championships and a rare spot in the North Coast Division V title game played at Albany had to completely retool his girls team the following season after the CIF run with a group of untested freshmen girls and his schedule against some of the best teams in the Empire bothered some Initial lopsided beatings for his freshman-dominated club at the hands of opponents like Drake Central Catholic of Modesto and Valley Christian would be on the horizon and the decision makers at the school asked Fagundes to pump the breaks a bit on his aggressive scheduling There were also issues on some girls being moved up and down on the JV and varsity rosters to assure that games on the schedule would be played Fagundes wanted to continue coaching both St but with the difficult schedule still in place He didn’t want to retreat from the girls program that he had built at the little school on Keokuk Street the tuition-paying parents of some of the girls were lobbying for an easier schedule and Fagundes moved on for short stints at Albany who had solid runs at Analy and El Molino before getting the job with the Mustangs His big issue at each school was that he did not have a teaching credential at the time Applicants for the coaching position who taught at those schools always got first consideration for the head coaching job I could look through the same lens as Fagundes Vincent with high hopes of building a strong program and students who could afford it might be encouraged to play Mustang basketball Vincent girls basketball appeared very bright It’s not very often that a coach gets a second chance at the same school encouraged to re-apply by people close to former Mustang players Academics is still tops on the priority list at the school but program building has been encouraged as well Several of the girls from the 17-10 club from last season are slated to return for the former Mustang coach and they appear to be excited about the prospect Leading scorer Alex Ditizio is slated to come back this season after an early ankle injury The lanky wing scorer came on strong under last year’s coach and averaged 11.2 points per game last year Ball handler and team emotional leader Alexandra Saisi is also back after leaving it all on the floor for the entire 2018-19 season She has already knocked in 19 points in the season opener Another missing link from the end of the season last year is Sophia Licata who averaged nearly six points a game before sitting out the final games with an illness She will be counted on to continue her improvement during the senior season First-year candidate Sophia Skubic could also help and she has jumped into the rotation for Fagundes already along with the development of some other young players with potential on the roster is recognized by almost all the local girls coaches in the Empire and he has already put his prints on preseason scrimmages with teams like Carondelet and a non-counting foundation game at Santa Rosa He will find out what kind of basketball grit his girls possess It will take a full season to evaluate the return of Jim Fagundes at St and the Lady Mustangs play through normal injuries and holiday vacations fans can assess the decision to bring the coach back for a second run (Contact George Haire at johnie.jackson@arguscourier.com) Dave Fagundes writes and teaches about property He joined the University of Houston Law Center faculty in fall 2016 and was appointed the Baker Botts LLP Professor of Law in 2018 Professor Fagundes began his teaching career at Southwestern Law School in Los Angeles he worked as a Bigelow Fellow and Lecturer in Law at the University of Chicago Law School Professor Fagundes' most recent and forthcoming scholarship focuses on property's abandonment doctrine the Second Amendment status of municipal corporations and the intersection of copyright and administrative law His articles have appeared in the Cornell Law Review His work has been selected for presentation at leading national venues including the Stanford/Yale Junior Faculty Forum and the plenary session of the IP Scholars’ Conference (on two occasions) and has been showcased four times in the Journal of Things We Like Lots (JOTWELL) Professor Fagundes was named the UHLC Order of the Barons Professor of the Year for 2019-2020 He was elected to the American Law Institute in July 2020.