Please press and hold the button until it turns completely green If you believe this is an error, please contact our support team 147.45.197.102 : bb0be532-e1ed-4fdc-a4ed-ec10bf10 Itapira, Brazil – At Interagro Lusitanos prospective owners can choose from literally hundreds of purebreds while seeing firsthand “living pedigrees” represented among the herds is the pristine home to approximately 450 Lusitano horses of elite bloodlines and specialized training Interagro’s Lusitanos have proven their ability in a variety of performance disciplines including dressage fluid gaits and sheer beauty have made Interagro horses sought after worldwide They are a favorite with both professional and amateur riders.“Go to the source,” says Interagro Lusitanos U.S You’ll also be selecting your “perfect” horse from hundreds of horses including the very finest that Interagro has to offer.If the enigmatic looks athleticism and movement of the Lusitano is what you’re dreaming of I have personally found so many super nice horses that you can get on right then and there and ride.”As further incentive the beauty of the breed is matched only by the majesty of the countryside that nurtures them The immersive equestrian experience that Interagro offers rewards prospective owners who choose to come and stay at the facility with the chance to experience firsthand the best of Brazilian culture and cuisine as well as countless hours in the saddle riding the horses they are considering bringing home “It is  a wonderful to truly get to know a horse you’re interested in by seeing how they handle themselves in a variety of situations: Paulo Gavião Gonzaga to preserve the Lusitano breed Interagro Lusitanos is the world’s largest breeder and exporter of Lusitano horses Gonzaga started with a small band of four mares and one stallion imported to Brazil from the breed’s native Portugal and since that first generation has produced more than 2,185 Lusitanos 450 horses populate Interagro’s 1200-acre six-barn showplace ranch (which has appeared on the covers of 21 international magazines) Interagro was recognized as ABPSL ‘Lusitano Breeder of the Year.’ Chester Weber and his family transform [...] Suzan Oakley an innovative leader and educator in advanced equine rehabilitation provides a healing refuge for equine athletes on the mend Registered properties of HorsesDaily®Inc. A media and marketing company for the Equine Industry. All content under this copyright is the property of HorsesDaily® Inc. Unless otherwise noted. ©1997 - 2025 horsesdaily.com and dressagedaily.com. All Rights Reserved. Enter your email address and we will send you a link to change your password. Cristália paves the way to developing new drugs and manufacturing processes Léo Ramos Company directors and researchers in Itapira was presented at the 2016 BIO International Convention an important global trade fair and conference held in the U.S Formulated by the pharmaceutical company Cristália the drug does not exactly offer anything new in terms of chemical substance or treatment but it does feature novelty with regard to how it is manufactured an enzyme once produced only in a culture medium that contained animal protein of the Clostridium histolyticum bacteria is now being produced at Cristália in a plant medium “This ensures that it contains no animal protein contaminants,” explains physician Ogari Pacheco Chairman of the Board of Directors and founding partner of the company Another advantage is that its active ingredient that was once imported is now being produced domestically “Collagenase provides painless treatment and our biotechnology center has managed to develop the active ingredient in the purest which opens the door to international markets.” “This was the first biotechnological product made from microorganisms from Brazilian biodiversity It was approved by the Brazilian Health Surveillance Agency (ANVISA) in April 2016 We received a warm welcome at the BIO Convention and are now planning to market the collagen domestically as well as internationally,” announced chemist Marcos Alegria a biotech firm in the area of sugarcane and oranges spun off from  the Xyllela fastidiosa Genome Project completed in 2000 “While pursuing my PhD at USP from 1999-2004 I also took part in sequencing the genome of the Xanthomonas citri bacteria Cristália is hoping its bold move with regard to collagenase will turn it into a representative of the Brazilian pharmaceutical industry that not only makes generic and herbal medicines but also innovates by marketing process technologies and unique active ingredients The path to innovation began in 2007 when after seven years of research the company developed the first Brazilian drug formulated from a novel active ingredient that had passed through all levels of clinical trials and production to arrive at the drug Helleva then one of only four medications in the world used to treat erectile dysfunction says that the company has always embraced innovation as a partner in a psychiatric clinic known as Cristália Pacheco saw the potential in a city that had several clinics of this type He built up Cristália to produce medications for the clinics and went on to produce products that were basically for hospital use such as anesthetics Cristália is present in 95% of Brazilian hospitals and exports to 30 countries in Latin America Revenue for 2015 was R$1.7 billion with 7% invested in research “Eighteen percent of this revenue comes from medications developed here in Brazil,” Pacheco says including 31 who hold PhDs and 18 who hold master’s degrees and are engaged in research Léo RamosChemical synthesis to produce pharmaceutical inputs at the R&D laboratoryLéo Ramos “We look for products that are more difficult to produce It’s not just about making copies,” says the company founder Cristália began to look outwards; seeking ideas from universities and research institutes that it could build upon the company established a scientific council in collaboration with a former medical school colleague of Pacheco a retired professor at the Institute of Biomedical Sciences (ICB) at USP who serves as council chair “Today there are dozens of universities and institutes presenting the council with results of their research or that of their development partners,” Scivoletto says The council looks to academia to find ideas for producing medicines researchers from both inside and outside the company introduce projects which undergo thorough analysis in terms of patents regulatory requirements and chemical synthesis The council is multidisciplinary in nature and includes researchers from USP and from the University of Campinas the Federal Universities of Rio de Janeiro (UFRJ) the chemical formulation is very good in terms of satisfying therapeutic requirements and wins council approval the company has developed 89 patents ­­– on molecules new uses of drugs and processes ­­– many international in scope consists of the New Products Department (DNP) and Research and Innovation Department (P&I) that make use of the same laboratory infrastructure One of the products under development in the P&I area is nanostructured mesoporous silica an adjuvant that can be used as a means for delivering oral vaccines may in years to come have a version that can be administered through drops This type of silica began to take shape in studies conducted by physicist Márcia Carvalho de Abreu Fantini at the Crystallography Laboratory of the USP Physics Institute researcher at the Immunochemistry Laboratory of the Butantan Institute who devised the substance for the vaccine to fight Hepatitis B the company and Butantan signed a partnership agreement to develop the vaccine adjuvant Léo RamosAnalysis of bacterial cultures in the study of new drugsLéo Ramos Mesoporous silica also proved to be capable of expanding the population protected by vaccines Many vaccines do not immunize everyone; sometimes only 90% of people “This has been shown to be the case in animals,” says biomedical scientist Danielle Cavalcante coordinator of Cristália’s Research and Innovation Department “Our studies are showing that this type of silica is a platform that can be used in other products Particles adhere not only to the surface of the vaccine antigen but also to the molecules of other drugs,” says Cavalcante The product is currently undergoing clinical testing She expects mesoporous silica to enter the market in two years No toxic effects Another drug developed at Cristália and already available on the market is Novabupi (bupivacain hydrochloride) “We modified the chemical structure of this substance to eliminate the part that causes toxicity making the injectable medicine more acceptable with fewer side effects,” explains pharmacologist Edson Lima director of Cristália’s Pharmochemical Division which produces 53% of the active ingredients used by the company Lima is a former professor at the Chemical Institute of the Federal University of Rio de Janeiro (IQ-UFRJ) as well as a former researcher at the Institute of Drug Technology (Farmanguinhos) Molecular modification and rearrangement comprise a product line on which Cristália is increasingly focusing its investment together with the formulation of new active ingredients One of the professionals working in this area is physicist Kesley Moraes de Oliveira in charge of triage and computer simulation of new molecules She worked on the Helleva project and says that the team has already studied more than 180 molecules Léo RamosReaction calorimeter in the scale-up laboratoryLéo Ramos In order to better position itself for the domestic market the company also focused on the infrastructure involved in manufacturing inputs it opened a biotechnology center in the same industrial complex situated along the highway that connects Itapira to Lindóia There the company is producing three medicines that are currently undergoing clinical trials: the generic monoclonal antibody trastuzumab for treating breast cancer; the protein etanercept for treating arthritis and psoriasis; and somatropin the human growth hormone produced using recombinant DNA technology based on hormone encoder gene cloning All of these initiatives have benefited from the consulting services of Spartaco Astolfi Filho a Minas Gerais company that developed technology to produce human insulin in the late 1970s That company was bought out by the Danish firm Novo Nordisk in 2001 The two have also encouraged researchers at Cristália to look to Brazil’s biodiversity for new molecules including those that could be used to produce new antibiotics © Revista Pesquisa FAPESP - All rights reserved playing in the first two of Brazil's three ill-fated games in England Bellini was born in the town of Itapira, in São Paulo state, and his first club was the local Itapira Atlético, followed by the São João da Boa Vista club, and Vasco da Gama in Rio de Janeiro, from 1952 until 1962. He then moved to São Paulo He did well enough not only to keep his place right through to the 1958 World Cup finals but to become captain After victory in the final he was presented with the trophy on the pitch and lifted it triumphantly above his head – an unusual and expansive gesture for the times and one that was to be much copied in subsequent years by other captains A statue of Bellini in that pose was eventually erected in front of the Maracanã stadium in Rio "There was nothing extraordinary about our defensive methods," he said about the team's performance in Sweden "I took it upon myself to tackle an opponent entering the defence from our right a striker from the left being handled by Orlando." Broadly speaking Bellini was a dominant figure throughout the tournament placing an emphasis on studying the opponents' buildup from midfield and assessing where the thrust would come from The Welsh inside-left Ivor Allchurch, background, leaps over Bellini, left, and Nílton de Sordi during the 1958 World Cup quarter-final match in Gothenburg. Photograph: APHe did have one fortunate moment during the goalless draw against England in the Ullevi stadium, Gothenburg, in Brazil's second match. Derek Kevan was racing through when Bellini brought him down He had stronger opposition to contend with when Brazil played France in Stockholm in the semi-final. The French players Raymond Kopa and Just Fontaine had proved a devastating combination with little Kopa making the bullets for the quick Bellini called him "the best getter of goals I saw in Sweden" Early in the game it seemed that Brazil would be in for a tormenting time, but an injury took the accomplished French centre-half, Robert Jonquet, off the pitch and the 10 French players eventually lost 5-2, with Pelé scoring a hat-trick did break through past Bellini for Sweden's second goal but In Chile four years later, Bellini was understudy to Mauro and did not get a game he felt that he made his contribution to Brazil's success in training tactical talks "and helping to stimulate and maintain the spirits of the party" In 1966 Brazil picked an older side He and the team survived their opening match against Bulgaria in Liverpool But in the second game Bellini and his fellow defenders could do little against the inspirational play of Hungary's ubiquitous centre-forward Bellini saw himself as a gentle giant, "a peaceful man off the field". He went into business with his in-laws, opening a shop, "and in that role I look very little like a football player, particularly the hard, combative player I am said to be." According to an interview in 2008 with Brasileiros magazine In recent years he had suffered from Alzheimer's disease Itapira, Brazil – The only thing more thrilling than the performances of Interagro Lusitanos at the Brazilian Championships hosted July 25-27 at the Jequitibá Training Center in  São Paulo’s historic municipality of Itu is the assurance that anyone can buy into the legend of this beautiful and versatile breed One of the most accessible and recognized breeders in the world Interagro Lusitanos showed talent and versatility across the divisions including the pairs horse title for Democrito Interagro and Cagliostro Interagro and driver Fabio R da Silva; the four-in-hand title for its matched buckskins de Souza; and Top 10 placings in Working Equitation for its sales horses and stallions (or garanhão).Pair winners Democrito and Cagliostro were put to Interagro’s matched buckskin quadra joining Crispim Interagro and Comanche Interagro to win the Brazilian Four-in-Hand title for Antonio de Souza Comanche and Crispim also proved their mettle as a pair and were third Second in the quadra was Ana Carolina Borja de Almeida driving Viajor Interagro and Semaneiro Interagro teamed with Erva Doce and Erótica.The Jequitibá Training Center set the stage for the Working Equitation (Equitação de Trabalho) Championships and premier of a “Speed” Working competition organized and conducted by CIA Working Equitation.In its largest Equitation division – Aspiring the reserve championship was won by Alexandre Sousa,and Ditador Interagro Sousa also won sixth place honors while debuting Diretor Interagro “It was the first time Diretor Interagro had left home and first show ever,” said Cecilia Gonzaga manager of operations for Interagro Lusitanos referring to the gray stallion’s debut in the championships’ Working Equitation division “He behaved extremely well.” Diretor Interagro and another horse from the Interagro working equitation team  “People,” Gonzaga said after the championships “can buy Interagro horses secure in knowing they are already competing I don’t know of any other Lusitano farm that has competition horses of this caliber and versatility for sale.” The reserve championship in the Equitação de Trabalho (Working Equitation) New Horses division went to Johnny Miranda riding Contractor Interagro and sixth was won by buckskin sales stallion Intermediate division entries Baliel Interagro and rider Benedito Torres de Macedo were fourth.Consistent winning and Top Ten performances throughout the Brazilian Championships spoke for themselves: The Interagro horse epitomizes the modern Lusitano a horse that excels in the traditional equestrian disciplines from dressage and driving to jumping and working equitation Interagro is committed to preserving the pure bloodlines of the Lusitano breed and its own bloodlines include some of the most respected of the breed: Faraó (JHC) Xique-Xique (CI) and Yacht (SA).Through their unique Destination Lusitano program Interagro hosts interested clients at the farm and immerses guests in the Luistano breed and culture at the farm From riding an Interagro stallion across the rolling Brazilian countryside to enjoying Portuguese cuisine and meeting the living pedigree of generations of Lusitano horses Destination Lusitano is an opportunity to purchase the horse  of your dreams while enjoying the journey of a lifetime.About Interagro LusitanosFounded in 1975 by Dr Paulo Gavião Gonzaga to preserve the breed Interagro Lusitanos are the world’s largest breeder and exporter of Lusitano horses Gonzaga started with four mares and one stallion imported to Brazil from the breed’s native Portugal; to date over 600 horses populate the 1200-acre ranch outside São Paulo Cecilia Gonzaga manages the farm and operations with a handful of the most premium stock presented at auction each year we are dedicated to providing premium-quality supplements that empower your health [...] Registered properties of HorsesDaily®Inc. 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