Fresenius Medical Care Expands Production of bibag® Dry Bicarbonate Concentrate Bags for Hemodialysis in the State of São Paulo in Brazil the world’s leading provider of products and services for individuals with renal diseases expands production of bibag® dry bicarbonate concentrate bags for hemodialysis in its Jaguariúna factory Fresenius Medical Care started the new production of bibag® in March of 2025 now produces bibag® in a high-level automated production line for the domestic market in Brazil as well as for export to various Latin American countries “This expansion positions Brazil to become one of the few countries in the world to obtain this advanced bibag® production technology,” said Alexandre Franco country manager of Fresenius Medical Care Brazil “The company’s major investment leverages state-of-the-art technology that elevates Brazil to emerge self-sufficient in bibag® production,” said Franco is a fundamental product for hemodialysis used in the treatment of chronic kidney disease (CKD) patients “This expansion involves the sharing of advanced technology positioning the Jaguariúna plant as a significant manufacturer of this product line” said Luiz Parente The country’s autonomy in supplying raw materials needed for bibag® was a key factor to making this project feasible.” a medical treatment that removes excess fluids and toxins from the blood when the kidneys are no longer able to perform this function effectively They provide a lightweight and streamlined alternative in comparison to liquid bicarbonate canisters allowing more protection since it dissolves directly in the machine This technology is more sustainable than other types of solutions used in hemodialysis therapy reduces transportation costs and avoids the use of big plastic canisters Fresenius Medical Care Celebrates 40 years of Dialysis Center in Sokolov Fresenius Medical Care places bonds with a volume of 1.1 billion euros Patient Care Technician Gives Dialysis Patient the Gift of Life Rapidly growing occurrences of cargo theft in the US have compelled two early-stage technology companies to use data around truckload movements to assist law enforcement Paper and forest product exports climbed for the first time in more than five years in 2024 but various headwinds will challenge demand in 2025 The broader goal of NYSHEX’s new container index is to provide rate information that will support the use of hedging tools for shippers NVOs and carriers against increased volatility Reproduction in whole or in part without permission is prohibited 43,000+ global companies doing business in the region 102,000+ key contacts related to companies and projects news and interviews about your industry in English Although they have lost their tourist appeal over the years there are still options for those wishing to embark on a rail journey in our state Travel back in time, explore breathtaking landscapes and experience the rich history of the state of São Paulo on board different compositions but there are still options for train rides in São Paulo From historical tours, aboard a steam engine, to adventures in the middle of the nature you can embark on unforgettable journeys on the state’s railroads So get ready to be enchanted by paths that wind through the Atlantic Forest historic towns and the beauty of the Serra da Mantiqueira 🎫 From R$ 50 at official website 📍Immigration Museum: Rua Visconde de Parnaíba This is because the steam locomotive travels along a 25 km route You can also enjoy a complete experience with breakfast or lunch on board 🎫 From R$ 50 at official website 📍Anhumas station: Avenida Doutor Antônio Duarte Conceição the company’s packages include special menus and guided tours in Itu and Salto 🎫From R$ 105 at official website itu Railway Station: Praça Doutor Gaspar Ricardo This historical and cultural tour aboard a themed train is an initiative of the ‘Associação Sorocabana – Movimento de Preservação Ferroviária’ (Sorocabana Association – Railway Preservation Movement) such as Railwaymen’s Day on April 27 The journey begins at the Paula Souza Station and continues to the Santa Maria Factory where the public also takes part in a guided tour of the Municipal Weaving Historical Park.  🎫 From R$ 17,50 at official website 📍 D outor Paula Souza Station: Rua Doutor Paula Souza Sundays and public holidays at various times 📍Emílio Ribas station : Avenida Emílio Ribas 🎫 from R$ 90 at official website or box office guararema Central Station : Rua Doutor Falcão 📍The train station varies according to the tour you choose Specialists predict a decline in the number of new diseases and plagues – and the related emergencies - resulting from climate change diseases in Jaguariúna: coffee plants enriched with CO2 are tallerEDUARDO CESAR Specialists are networking to predict the possible effects of climate changes on agribusiness which accounts for one third of Brazil’s GDP There are signs indicating that the production of soya and other crops may decline dramatically and the incidence of diseases may rise as a reaction to the probable increase in temperature and changes in rainfall distribution throughout the country The fear is that prices will go up and the variety of grains In anticipation of scenarios that predict harsh times ahead research centers and companies are developing and introducing varieties of grains and vegetables that are more resistant to high temperatures and to attacks from organisms that cause diseases and plagues consumers and also the economy will readjust and rebalance A study funded by the World Bank enabled researchers from the State University of Campinas (Unicamp) and from the Brazilian Agricultural Research Corporation/Embrapa’s Agricultural and Animal Husbandry Infotech to use 23 computer simulated models related to the global climate and to three regional climates These simulations detected a clear tendency for cotton wheat and corn yields to drop as an effect of the probable rise in temperature from 2020 to 2030 This drop may correspond to 64% in the case of beans even from the most optimistic point of view where the annual mean temperature goes up insignificantly the yield of beans may drop by 70% and soybeans only sugarcane and pastures will benefit from a warmer climate a research project coordinated by Embrapa Meio Ambiente has identified that some diseases – especially those caused by fungi – and pests may increase in many of the 19 crops analyzed in the project mangoes and grapes – will be affected by higher levels of CO2 in the air by warmer temperatures and stronger ultraviolet B radiation as predicted in climate change scenarios (see table) Another possible consequence is the migration of diseases such as the black sigatoka caused by a fungus that destroys banana plantations Specialists believe that the disease will decline in some banana-producing regions and will migrate to the south where no incidence of this fungus has been seen yet “The battle against these diseases is endless,” says Wagner Bettiol “The plants and the plagues in the upcoming decades may be different from the current ones.” The prediction is that the incidence of some diseases may increase and others may decrease “But it’s impossible to generalize what will happen,” says Raquel Ghini a researcher at Embrapa in Jaguariúna and coordinator of the Climapest project Created three years ago thanks to a R$ 5 million investment from Embrapa and R$ 2 million from other public and private institutions and companies the project brought together 134 researchers from 17 Embrapa units and 22 research institutes and universities and is expected to result in a book – scheduled for publication by the end of the year – with maps indicating the probable distribution of agricultural diseases and plagues in Brazil in the upcoming decades “A warmer climate drives the proliferation and reproduction of insects,” says José Parra a professor at the Luiz de Queiroz School of Agriculture (Esalq) of the University of São Paulo (USP) Parra is also the coordinator of the biological control of plagues department at the National Science and Technology Institute He adds that “the damage depends on interaction with other insects and with the environment natural enemies might develop faster and control the plagues as could happen in the case of citrus fruits the plagues might change and those that are more resistant to high temperatures will prevail,” he says Visible effects “We have clearly seen that the number of coffee plantations has dropped significantly and actually disappeared in the northwest region of the State of São Paulo and in the southern region of the State of Minas Gerais These regions have been affected by rising temperatures in the last few decades,” says Hilton Silveira Pinto a researcher at Unicamp and one of the coordinators of the study funded by the World Bank Previous studies indicated that the availability of land for coffee crops will drop by nearly 90% in the regions suitable for the planting of coffee in the states of Goiás Minas Gerais and São Paulo and by 75% in the state of Paraná by 2020 Coffee will most likely continue to be planted only in the highlands of the southeast or further down south “Climate change is already changing the transportation and distribution networks and rural organization the result of unemployment or the migration of skilled labor.” The increase in carbon gas (CO2) levels in the air might have a positive effect in the sense of increasing crop yields and making plants grow faster Embrapa in Jaguariuna is conducting an experiment called FACE – the acronym for free air carbon dioxide enrichment – in which the coffee plants enriched with extra doses of CO2 grew taller and are now as tall as those planted a year before that were nourished by the CO2 found in the atmosphere The Face experiment which started in August 2011 is being conducted on 6.5 hectares of land planted with coffee Twelve octagons with 10-meter diameters stand out in the midst of these plants The coffee plants on six of the octagons are enriched with CO2 with a concentration of 550 parts per million (ppm) simulating the atmosphere at the end of the century sensors automatically activated according to the direction and strength of the wind release 600 kg of the gas onto the plants The carbon gas comes out of a 10-meter tank The coffee plants on the other six octagons only get the CO2 from the atmosphere with a concentration of 400 ppm –higher than the 350 ppm that Raquel used 10 years ago to predict plant behavior nobody believed anything being said about climate change,” she says The accelerated growth of plants can also be a problem flower growers in the town of Holambra noticed that the plants flowered earlier than expected because of the increase in the region’s mean temperature accelerated growth is a tragedy for flower suppliers who must deliver fresh flowers into the hands of consumers on special dates such as the eve of Mother’s Day or during All Souls’ Day At Embrapa Semiárido in the city of Petrolina Francislene Angelotti has conducted a number of tests in open greenhouses She noticed that the main fungi-caused diseases that damage grapes – mildew and plant rust – react differently to the increase in CO2 concentrations Differences were also found according to the grape variety The Sugraone variety proved to be more sensitive to rust whereas the Crimson variety was more sensitive to the fungus that causes the powdery mildew on the grape vines mildew was less aggressive to the Italia variety the incidence of the fungus that causes powdery mildew on tomatoes The fungus that causes mildew on lettuce and at present only thrives in cooler temperatures and lower humidity will probably become less recurrent in a warmer However specialists warn that the disease-causing agents can adapt or come out of the shade a microorganism that causes mildew in pumpkins the microorganism has already adapted itself to a warmer “Mildew has become a common disease in the north of the state of Minas Gerais because the fungus has already adapted itself to a warmer climate,” says Kátia Regiane Brunelli a researcher at Sakata Seed Sudamerica Ltda. a Japanese corporation that develops and produces genetically improved vegetable seeds “Since the climate tends to become warmer and drier,” says Romulo Fujito Kobori the company’s director of research and development “some virus-caused diseases might become more prevalent than they are nowadays.” Alternative varieties Soon after his conversations with the team from Climapest on the diseases most likely to prevail in the forthcoming years Kobori and his team of geneticists began to intensify the search for varieties that are more resistant to climate changes A visit to the greenhouses and to the vegetable plots at the company’s experimental station in the city of Bragança Paulista attests to the fact that the work has matured for most of the vegetables subject to genetic improvements: “In 20 years this variety of broccoli won’t be any good but this other variety will do well,” he says pointing to the vegetable plots in front of him The vegetable plots are planted with broccoli and tomatoes with subtle yet decisive differences in terms of size zucchini and cucumber varieties that had become genetically resistant to fungi viruses and bacteria expected to proliferate significantly in tropical regions in the upcoming years This is long-term work: each new variety needs 10 to 15 years of work until it becomes commercially feasible Kobori hopes that molecular biology techniques will cut this time by half by identifying the plants with the genes that have the characteristics of interest The genetic selection of new varieties of fruit trees takes even longer “The varieties we are using are 60 years old,” says Renato Bassanezi a researcher at the Fundo de Defesa da Citricultura (Fundecitrus) a research center funded by citrus fruit growers from the city of Araraquara Orange trees that are more resistant to climate change would be most welcome because climate change is already interfering in citriculture one of the major economic activities in the State of São Paulo The state is the leading Brazilian producer of oranges and one of the biggest such producers in the world 230 million orange trees are currently being cultivated in the state growing on the leaves of a cucumber plant: one of the likely hazards that will have to be dealt with in the futureEDUARDO CESAR unexpectedly heavy rains in the orange growing region jeopardized the flowering season and triggered the growth of fungi; the crop yields went down by 10% because the weather was dry in the following year Nearly 20 days of steady rainfall in early June this year is expected to lead to early flowering which will again trigger the growth of weeds bacteria-caused disease that proliferates easily may become more serious in a climate whose average yearly temperatures are high and rainfall is heavy and concentrated “If the predictions on climate change are confirmed,” says Bassanezi “the country’s north and south regions will become more susceptible to citrus canker epidemics.” Germplasm banks If plagues and diseases become more prevalent the germplasm banks – organized collections of rice corn and other plant varieties of economic interest maintained in refrigerated rooms or in the field – will become increasingly important The current state of the germplasm banks is not good because there is no updated inventory of the collections “The collections of less than 10% of the germplasm banks are properly described,” says José Baldin Pinheiro a professor at Esalq and president of the Paulista genetic resources network At a meeting to be held in the city of Piracicaba at the end of this month the members of the network will present updated information on the collection and the state of conservation of the germplasm banks in the State of São Paulo It is possible that many plants that will comprise agriculture in the future are already being cultivated in the northeast of Brazil Francislene moved from the state of Parana to the city of Petrolina At that time she had already marveled at how resistant the region’s plants were to drought and at their power to regenerate the plants looked as if they had been burnt by fire; two weeks after heavy rainfall and Japanese persimmons grown in Embrapa’s experimental fields and was quite surprised “The pear varieties cultivated at the Agronomy Institute of Campinas and the apple varieties cultivated at the Agronomy Institute of Parana adapted very well,” says Paulo Coelho Lopes coordinator of the crop diversification project conducted at the Embrapa Semiárido unit “Nobody had ever believed that fruit grown in a temperate climate could flourish here.” The Projects 1. The effect of global climate change on plant diseases (nº 04/01966-7); Modality Regular Line of Funding for Research Project; Coordinator Raquel Ghini – Embrapa Meio Ambiente; Investment R$ 61,151.03 (FAPESP) 2 Climapest; Modality Embrapa Macroprogram; Coordinator Raquel Ghini – Embrapa Meio Ambiente; Investment R$ 5,028,798.47 (Embrapa) Scientific article GHINI, R. et. al. Climate change and diseases of tropical and plantation crops © Revista Pesquisa FAPESP - All rights reserved Please enable JS and disable any ad blocker