iStock, Yutthana Gaetgeaw Mirador Therapeutics is not making immunology and inflammation medicines for today CEO Mark McKenna wants to be the creator of 2030’s great breakthrough in the space “We are trying to figure out where the puck is going to be in that 2030 timeframe not where it is necessarily today,” McKenna said The precision medicine biotech, which arrived on the scene almost exactly a year ago with a whopping $400 million in Series A financing One is to build out a pipeline of therapies for immune-mediated inflammatory and fibrotic diseases The other is to buy some assets in those areas to turn the early-stage biotech into a clinical-stage one sooner rather than later McKenna told BioSpace on the sidelines of the J.P Morgan Healthcare Conference in January that his team had combed through data on about 300 different potential programs thinking that such an acquisition would be the quickest way to the clinic But Mirador’s own precision medicine platform has been churning out potential gems faster than expected “We went into this maybe thinking that 80% of our innovation would come from external Mirador has been intentionally quiet on its activities since launching While speed was once the currency in biotech Operating in stealth has become particularly important given increasing pressure from innovative biotechs coming out of China “We’re driving a bigger competitive mode by keeping our cards close to the vest,” McKenna said What we’re looking for is really cool science that’s going to move the field forward.” McKenna did give a little detail on what the team has been doing The focus has been on truly novel precision medicine targets and combination therapies that are the next big thing in their indications Mirador is currently working on moving five to six programs towards the clinic He declined to provide further details or a timeline for naming indications and candidates “This is going to be a really exciting story in the back half of this decade as we start to figure out what is the next breakthrough therapy in this in this class,” McKenna said McKenna said the external asset search was supposed to be the starting point He said the team looked at T cell engagers but determined that to be a tough area given the competition One of the challenges of finding new drugs to develop right now is that Mirador is “looking in the same pools as Big Pharma.” The company also plans to apply its Mirador360 precision development platform to the external assets The technology analyzes patient molecular profiles to discover genetic associations to immuno-fibrotic diseases This can help pin down specific populations develop diagnostics and generate clinical development programs only a few have passed through our funnel,” McKenna said of the assets Mirador has looked at Mirador’s first fundraising was a big one, landing in the top of venture capital raises for 2024 But just because the company is cash-comfortable doesn’t mean McKenna isn’t being careful He said the goal has been to ensure the R&D engine is productive in relation to every dollar spent The $400 million raise was led by ARCH Venture Partners with other participation from OrbiMed and Fairmount early on plus more than a dozen other venture and hedge funds This has positioned Mirador well for when the company begins to look at the public markets It’s focusing on advancing these programs into IND and in the clinic,” McKenna said For a complete list of NextGen 2025 companies, click here The NextGen Class of 2025 is brought to you by Pliancy 2024 (GLOBE NEWSWIRE) -- 23andMe Holding Co a leading human genetics and preventive health company a next-generation precision medicine company focused on developing first-in-class or best-in-class therapeutics for immunology and inflammation (I&I)-related diseases today announced a strategic research collaboration Mirador will leverage a targeted set of aggregated de-identified genetic and phenotypic data from the 23andMe research database and its proprietary Mirador360™ development engine to enable target validation and precision medicine as well as two clinical stage assets in immuno-oncology Mirador will use the 23andMe database to augment its proprietary Mirador360™ development engine which already houses one of the most extensive repositories of immune-mediated disease data including over two million human molecular profiles “Our new partnership with 23andMe supercharges the Mirador mission to rapidly advance transformational precision therapies for patients living with chronic immune-mediated inflammatory and fibrotic diseases,” said Mark C “Combining Mirador360’s cutting-edge biology multi-modal data and AI capabilities with the unparalleled genetic and phenotypic insights from the 23andMe database will enable us to accelerate our progress toward solving major unmet needs in I&I.” “Mirador is a pioneer in I&I precision medicine and our collaboration harnesses the power of 23andMe’s data and research platform to identify new targets and develop promising new drugs,” said Anne Wojcicki “We hope this can ultimately help the millions of patients living with a range of I&I diseases who urgently need treatment options.” Protecting participant privacy23andMe has strong privacy protections in place and customers are in control of their data Customers have the option to consent to participate in the 23andMe Research program which is overseen by a third party Institutional Review Board (IRB) to ensure research being conducted meets the highest ethical standards Only data from consented research participants is used for 23andMe research their information is de-identified for research activities meaning participants’ personally identifiable information such as name sex and contact information is stripped from their genetic information with the two sets of data stored separately If a customer originally opted-in to participate in 23andMe’s Research program About 23andMe23andMe is a genetics-led consumer healthcare and therapeutics company empowering a healthier future. For more information, please visit www.23andme.com MiradorMedia: dan@1abmedia.com You can turn to OPB for stories about the people and places that make our region unique thanks to member support. Join in now! March 31Mirador is a quarterly magazine published in Oregon and the UK Its thirteenth edition is titled "Bubble and Pop" was released in March 2025 It features cover artwork by an artist living with Alzheimer's disease and stories about the history of bubble gum a popcorn history museum and other content Courtesy of Mirador Magazine / artwork by Carlos Olivas Jr According to a recently published study more than 40% of adults over the age of 55 in the U.S have a lifetime risk of developing dementia New cases of dementia are also projected to nearly double to 1 million a year by 2060 The cognitive decline and memory impairments associated with Alzheimer’s disease and other forms of dementia can make it difficult to follow the branching storylines of a novel or the flow of facts in a newspaper or magazine article But as traditional avenues for literary enjoyment close, new ones can and should open for this growing population. That’s the guiding mission behind Mirador a quarterly magazine Nikki Jardin co-founded in Portland nearly four years ago to be accessible to people with dementia to the way paragraphs are structured or photos are displayed to accommodate changes to vision and recognition the whole magazine is designed with dementia in mind Jardin joins us to talk about the inspiration for starting Mirador and the magazine’s recent international expansion and collaboration with other dementia-friendly publications Note: The following transcript was transcribed digitally and validated for accuracy readability and formatting by an OPB volunteer Dave Miller: From the Gert Boyle Studio at OPB over the age of 55 have a lifetime risk of developing dementia That’s according to a recently published study New cases of dementia are projected to nearly double to 1 million a year by 2060 The cognitive decline and memory impairments associated with Alzheimer’s disease and other forms of dementia can make it difficult to follow novels but as traditional avenues for literary enjoyment close new ones can open for this growing population That is the basic guiding mission behind Mirador Nikki Jardin co-founded the quarterly magazine in Portland nearly four years ago to be accessible to people with dementia Nikki Jardin: Thanks so much for having me Miller: I’ve read that your personal impetus for starting this magazine was that you became your aunt’s primary guardian a few years ago when she was diagnosed with young onset or early onset Alzheimer’s - that was at the age of 63 so it took the family a little while to figure out what was going on with her dementia diagnosis she actually would go to the library and read to kids out loud we found out through one of her pet sitter clients [who] realized that something was going on And we got together as a family and tried to figure out how we could best help Rebecca One of the things that we decided was that she should move down here to Oregon and be closer to me so that I could help with what she needed during the course of that journey She liked to share with us the things that she was learning So magazines were really the kind of publication that she was drawn to But she liked a lot of different kinds of magazines across the spectrum but she liked being able to call us up and say “did you see this,” because we shared some publications Reading was a big part of her life – and in fact when she lived in long-term residential care she really wanted me to keep those subscriptions going That was a big part of what she asked me to do understand and follow the articles in the magazines that had previously been a major part of her life Jardin: That was one of the first things that I started to notice was that she would carry the same issues around with her all the time but not interact with them in a way that I was used to her interacting with them Like she wouldn’t open them up and read with me because I didn’t really know much about Alzheimer’s when I came into this role with her that she was no longer interested in reading Miller: What made you decide to actually change that and challenge that assumption Jardin: I had a really good friend at the time named Judy who worked in memory care and had for a couple of decades She turned me on to a woman named Teepa Snow who a lot of people in the dementia care community recognize as a leading care expert in this field I started watching Teepa’s videos on YouTube She just happened to have been doing a live And one of the things that I learned about dementia at that talk was that visual acuity is affected pretty early on in a dementia diagnosis Something in that conversation clicked to me that maybe it wasn’t that Rebecca wasn’t interested in reading I was going to just buy her dementia-friendly magazines I’m going to just get all of them that there are,” thinking that why wouldn’t there be … Miller: … And we’ll see which one she likes Miller: Did you consider magazines for kids because of the layout or the complexity of the sentences even if the subject matter would be completely inappropriate and I think that that can be one of those avenues that people tend to go down … But she was really struggling with this diagnosis and it was hard for her I think one of the things that was so hard about that journey for her was that she would call herself stupid or she would call herself dumb and it was because she couldn’t interact with the things that she would normally do I didn’t want to compound this by giving her children’s books and I didn’t think it was necessary And I was surprised that there was … There were some chapter books available for people you saw something that should have existed “I guess it’s up to me to actually create this thing.” But how did you start Jardin: I was lucky in that I had a freelance writing background and I’d worked on a local publication as a writer and managing editor for Spot Magazine which was a great pet-themed magazine here I also was lucky to have some really talented friends I was just thinking maybe this is something we can format together and put together who I played music with in a band and who had a great graphics eye Then I was able to find out through some research that there was a guide out of the UK called the DEEP guide which is the Dementia Engagement and Empowerment Project where they used people living with dementia to put together basically a protocol on how to develop pages so that they could be easier to read every magazine creative for every audience is thinking about that stuff But you have a specific population in mind What are some of the design choices that you made Jardin: There was a prototype that I put together that has only been seen by a couple of people So we started with that and then realized that that wasn’t the way to go We looked at this DEEP guide and we just started molding something into what it is now larger typeface … looking at the font – which is a sans-serif font – is easier to read the little bits and curly q’s … straighter edges Color and contrast is used a lot to pop that text out a little bit All these things we started developing and looking at what makes a layout as clean as possible using photographs instead of illustrations can be easier for people to pick up Having your content on one page or a double-page spread not having to go to page seven to finish the story All of our stories are between 50 and 250 words if a word is going to go too long and there’s going to be a hyphen in the second half of the word that would be in the next line – you don’t do that Jardin: We just want to make sure that the flow is really clear and crisp And if somebody is following a line and it breaks off that could interrupt the flow to the brain as they’re trying to follow along the story We want to try to find every piece of technical prowess we can find Another thing that we’ll do is make sure that our sentences — we’re still using an adult vocabulary keeping paragraphs nicely delineated on the page How do you decide what kinds of stories to focus on Jardin: All of our magazines are themed in a general way but I think what I was going in with was that I did want to create a product that my aunt would really enjoy and I wanted to make it interesting for anybody that picked it up Maybe they wouldn’t find this one thing interesting We do a “spot-the-difference.” We wanted to put in a photo comic Tavé and I were talking about it and realized that Judy was saying that seeing smiling faces of people is really important to this audience Jardin: It’s called “The Adventures of Chicken and Dumplings.” It is myself and Tavé as these characters the “Chicken and Dumplings,” who are really these vivacious characters and they bumble about in the world but everything is beautiful to these characters And they’re always just happy-go-lucky and kind of stumble into things resistant to do it because I didn’t necessarily think that my picture needs to be in the magazine … Tavé and I had done some touring with the band and we used to take these photos of each other So we put one of them together as this really ridiculous event that we had out in Idaho We showed it to Judy and showed it to people and actually that particular feature in the magazine is probably one of the most popular features in the magazine Miller: How do you assess whether what you’re doing is working We get a lot of feedback from our readers and that really helps us to develop content I hear stories all the time from our readers that say that they’re so happy that their mom their sister or their husband has something that they can really engage in themselves Miller: You said you get feedback from readers but it seemed like you’re then combining the caregivers who are reaching out to you I was just over there for a trip last year and he said one of the things that he really likes about the magazine is that (a) it looks like a regular magazine and (b) he likes that the format is easy to digest and he can follow along with it Miller: I noted that the issues don’t have dates The latest one is called “Bubble and Pop,” that’s the theme but it doesn’t say “Spring 2025,” it says “Volume 13: Bubble and Pop.” How’d you come up with that decision Jardin: One of the things we also really wanted to do is to make sure that the magazines were evergreen it didn’t matter what month you picked it up or what week Miller: Does that mean that you’re also designing this magazine with the idea that it might be read many times One of the things that we also really wanted to do who ended up being a co-founder of the magazine we spent a lot of time at the printer before the first issue making sure that the pages were thick enough that they could be turned easily But also because we had a feeling that these were going to be looked at multiple times – whether they were in a long-term care facility or whether they were just at home with people – that they’re gonna get picked up on a daily basis Miller: What do you think of as the biggest preconceived notions about dementia that you would like to overturn is that people aren’t interested in reading or that they don’t like to read I think a lot of autonomy for people gets removed the minute that a dementia diagnosis comes on board There are lots of people living well with dementia that people with a dementia diagnosis are advocating more for themselves and saying you should talk with me about my decisions and what I want.” Miller: You have a pretty small number of subscribers right now What’s your plan for how to spread the word about this but I think it’s a very grassroots publication Mirador is collaborating with other … Since we started this there have been a handful of other publications that have come on board: Nana’s Books Collaborating with those folks and talking about it through social media about how important this resource is for people living with dementia Miller: The most recent issue just came out but can you give us a sneak taste of the next theme Miller: Nikki Jardin is co-founder and publisher of Mirador Magazine It was created to be accessible for people with dementia If you’d like to comment on any of the topics in this show or suggest a topic of your own, please get in touch with us on Facebook, send an email to thinkoutloud@opb.org or you can leave a voicemail for us at 503-293-1983 The call-in phone number during the noon hour is 888-665-5865 Tags: Think Out Loud, Reading, Alzheimer'S Disease Stand with OPB and protect independent journalism for everyone Listen to the OPB News live stream (opens new window)Streaming Now the new band co-founded by Greta Van Fleet’s Jake Kiszka and Ida Mae’s Chris Turpin announce that they will expand their headlining tour to 31-dates due to popular demand Tickets for all initial dates sold out immediately upon going on sale and a second run of fall dates in larger venues have been added in Nashville and new dates have been announced in New Orleans GRAMMY® Award-winning Greta Van Fleet founding member Jake Kiszka shares vocal and guitar duties with co-vocalist and guitarist Chris Turpin of Ida Mae MIRADOR Tour Dates (NEW DATES IN BOLD)May 10 – Nashville TN at Basement EastMay 13 – New York NY at Bowery BallroomMay 15 – Washington DC at The AtlantisMay 17 – Detroit MI at St Andrews HallMay 18 – Chicago CO at Bluebird TheaterMay 23 – Los Angeles CA at Bottlerock FestivalSept 12 – Chicago IL – The MetroSept 13 – Madison WI – Majestic TheatreSept 14 – Grand Rapids ON – Opera HouseSept 18 – Boston MA – Paradise Rock ClubSept 19 – New York NY – Webster HallSept 20 – Philadelphia NC – Lincoln TheatreSept 23 – Atlanta GA – Terminal WestSept 24 – New Orleans LA – Tipitina’sSept 26 – Oklahoma City OK – Beer City Music HallSept 27 – Dallas TX – Granada TheaterSept 28 – Austin AZ – The Van BurenOct 2 – Los Angeles CA – The Fonda TheatreOct 3 – San Diego CA – The Observatory North ParkOct 6 – Portland OR – Wonder BallroomOct 7 – Seattle WA – The ShowboxOct 8 – Vancouver BC – Vogue TheatreOct 10 – Salt Lake City CO – Gothic TheatreOct 13 – Lawrence KS – The GranadaOct 14 – Nashville Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page featuring Greta Van Fleet guitarist Jake Kiszka The outing kicks off May 10 in Nashville and will wrap up May 23 in Los Angeles Songs have been committed to the master tape Our hearts are aflame,” Mirador says “Our live shows will feature brand new songs from our upcoming album Details of the full length will be forthcoming For the full list of dates and all ticket info, visit MiradorBand.com. Greta Van Fleet’s most recent album is 2023’s Starcatcher. Copyright © 2025, ABC Audio. All rights reserved. Need help accessing the FCC Public File due to a disability? Please contact Larry McFeelie at publicfilephoenix@hubbardradio.com or (602) 629-8709. This web site is not intended for users located within the European Economic Area. Sign In Register There are times you look at buildings and wonder what goes on inside. Last year, as I sat outside at Starship Bagel in downtown Dallas I looked across the green plaza with the giant eyeball and gazed up at the adjacent building Located in the penthouse of luxury boutique Forty Five Ten The restaurant itself is a pastiche of floral pastels The large windows give the space a light and airy feel and the patio is a delightful spot to dine as the weather cools with views of Main Street and the Giant Eyeball But there are many good-looking restaurants in North Texas.  I have a theory: Judge a restaurant on the simple stuff then they no doubt are doing the same on the more baroque dishes As soon as I took a bite into the pancakes with lemon ricotta and blueberry I thought the rest of the brunch was going to be delicious and the wagyu short ribs with steak and eggs followed but two old fashioneds: their signature "high fashioned" and a truly wonderful banana bread old fashioned with bourbon Mirador is doing a special back-to-school brunch promotion But you know what's an even better one Mirador's delicious food and drink.  "We really want to get the word out," Channing Johnson I remember back to that time at Starship Bagel looking up and wondering what was going on below the vaulted windows above A post shared by Local Profile (@localprofiletx) Hungry for more? Check out our dining guide Don't miss anything Local. Sign up for our free newsletter More Partner Content > © 2025 Local Profile is a registered trademark of Community Profile LLC Mark McKenna is founder and CEO of Mirador Therapeutics a company driving a new era in precision medicine for immune-mediated inflammatory and fibrotic diseases co-head of Goldman Sachs Global Banking & Markets about establishing a pace of innovation at Mirador that delivers novel medicines to patients faster This session was filmed at our 2024 Builders and Innovators Summit On the sidelines of this year’s J.P. Morgan Healthcare Conference in San Francisco, BioSpace Senior Editor Annalee Armstrong sat down with Mark McKenna, CEO of Mirador Therapeutics, a member of BioSpace’s NextGen Class of 2025 Their discussion here focused on the company’s two-pronged approach to developing therapies for inflammatory and fibrotic diseases as well as the importance of operating under stealth at this time for the biotech This is the third episode in a special series of The Weekly focused on how NextGen companies are navigating the current business environment Annalee Armstrong Mark McKenna For a complete list of NextGen 2025 companies, click here.The NextGen Class of 2025 is brought to you by Pliancy We use cookies to analyze user behavior in order to constantly improve the website for you. Learn more San Jose, California--(Newsfile Corp. - August 6, 2024) - Mirador Living is proud to announce the launch of its groundbreaking platform designed to assist aging seniors and their families in finding the right senior living option, whether that be assisted living This initiative stems from a personal experience of one of Mirador's co-founders who faced significant challenges while searching for quality assisted living for his grandmother The journey was marred by opaque processes highlighting the urgent need for a thoughtful overhaul of the system Mirador Living's new platform aims to address these issues by bringing transparency and simplicity to the senior care market the platform ensures that families can make informed decisions with ease The intuitive interface guides users through the process providing clear and concise information about various assisted living options thereby eliminating the confusion and frustration often associated with such searches emphasizes the importance of this innovation in the senior care industry "When finding the right senior living community is straightforward and transparent it leads to better experiences for families and their loved ones Our platform is designed to transform this journey making it more transparent and accessible." The platform's development is a manifestation to Mirador Living's commitment to enhancing the quality of life for seniors and their families By focusing on transparency and user-friendly design Mirador Living is setting a new standard in the senior care market The platform not only simplifies the search process but also ensures that families have access to all necessary information to make the best possible decisions for their loved ones Mirador Living operates with the mission of bringing transparency to the fast-growing senior care market This latest innovation is a significant step towards fulfilling that mission providing a much-needed solution to a widespread problem As the senior population continues to grow the demand for reliable and transparent assisted living options will only increase Mirador Living's platform is poised to meet this demand offering a valuable resource for families navigating the complexities of senior care Mirador Living reaffirms its dedication to transforming the senior care industry The platform is now available to assist families in making informed and confident decisions about assisted living options for their aging loved ones Mirador is bringing transparency to the fast-growing senior care market Mirador Living, Inchttps://www.miradorliving.comBrandon Blakeleybrandon@miradorliving.com To view the source version of this press release, please visit https://www.newsfilecorp.com/release/218999 SOURCE: Mirador Living, Inc. Sign Up Company Profile Real Estate Copyright 2025 Newsfile Corp. All rights reserved. "We are coordinating with the company to advance the negotiations on the addendum that will allow us to improve investment commitments expand activities and improve state revenues," deputy mines minister Rebeca Illescas told BNamericas The signing of the addendum will make phase II of the copper concession viable so the company can expand the processing rate of the Mirador I deposit (south) to 80,000t/d from the current 60,000t/d and develop the Mirador Norte pit to process another 60,000t/d Mirador Norte will require investment of around US$650mn EcuaCorriente has been seeking the signing of the addendum since last year in its contract with the Ecuadoran State signed in 2012 committed to build the US$216mn Santa Cruz-Hidrocruz hydroelectric plant to self-generate 138MW and guarantee long-term power supply for Mirador it’s impossible to sign an addendum that doesn’t contemplate the investment commitment and the schedule of what the energy solution will be so that they can double their operation We’re going to sit down with EcuaCorriente at the negotiating table and one of the crucial points is to determine how they’re going to handle the electricity issue They’re aware of this and are looking for a solution,” said Illescas The official added that given the country’s electricity crisis and the effects of climate change it is not possible for Ecuador to ensure electricity generation for large projects that do not have self-generation Among the large-scale advanced mining projects that will have significant demand for electricity Canadian company Solaris Resources’ Warintza and Lumina Gold's Cangrejos which are seeking their own alternatives to supply electricity for their future mines Companies with medium-scale mining projects such as SilverCorp and Salazar Resources’ Curipamba and Atico Mining’s La Plata are also looking for generation alternatives hydropower-dependent Ecuador has been affected by a serious electricity crisis Ecuador meets around 80% of its electricity needs through hydroelectric plants and nearly all these are located in the area where drought hits year after year and with increasing force due to climate change Given the low level of the rivers that feed the main hydroelectric plants and the limited availability of thermal energy the government of Daniel Noboa had to resort to scheduled power cuts throughout the country and in October grid operator Cenace asked large companies to reduce electricity consumption and opt for self-generation electricity rationing was due to end for the residential sector this measure will not apply to seven large consumers: EcuaCorriente; Canada’s Lundin Gold owner of the Fruta del Norte gold mine; steel companies Adelca and Novacero; and cement companies Holcim which from December 15 until the end of the year must keep electricity consumption to a technical minimum Other industries will be subject to cuts of up to eight hours a day EcuaCorriente is the most affected by the decision because it requires around 87MW and self-generates no more than about 4MW while Lundin Gold activated its maximum self-generation capacity and is also applying other measures to avoid impacting operations Subscribe to the leading business intelligence platform in Latin America with different tools for Providers The project involves a 14.8MW photovoltaic plant and 40.9MWh of storage Some countries in the region have advanced in terms of regulations aligned with energy transition goals encompassing areas including remuneration .. Subscribe to Latin America’s most trusted business intelligence platform Get critical information about thousands of Electric Power projects in Latin America: what stages they're in Get critical information about thousands of Electric Power companies in Latin America: their projects Subscribe to BNamericas to find news reports information on projects and contact information relating to thousands of companies that drive business in Latin America Request a demo and access exclusive content Addepar today announced it has entered into a reseller partnership with UNHW reporting firm Mirador Under the new partnership, Mirador will make available to its client base and prospects a version of Addepar that has prebuilt analytics and reporting tools specifically tailored to single family offices and wealth management firms with less than $300 million in assets under management Addepar now serves over 300 financial services firms registered investment advisors and private banks with data aggregation and analysis of investment data and reports on over $1.3 trillion in assets on its platform Davis Janowski is a New York-based technology journalist whose work spans consumer Janowski worked for Forrester Research as an analyst covering Digital Wealth Management His work covering the advisor tech space began in 2007 when he joined InvestmentNews as the advisor industry’s first dedicated technology reporter His start in tech journalism began as an editor with PC Magazine in 1999 where he later served as an analyst and reviewer His work has appeared in The New York Times including Technology Tools for Today's High Margin Practice He has also been a speaker and moderator at numerous industry conferences Outside his day-to-day he is a senior guide for Manhattan Kayak Company in New York City RIA Edge 100: Growing Rapidly but Responsibly What truly sets peak performing retirement plans apart Tech Stacks & Growth Strategies for Future-Ready Advisory Firms Ask the Experts: Grow Your Practice with Philanthropy: Comparing DAFs and Private Foundations See how advisors are combining active and passive strategies for optimal portfolio results Registered in England & Wales with number 01835199 We're sorry; the page you're looking for is either offline now Please use the search options to find what you're looking for Find tour dates and live music events for all your favorite bands and artists in your city NASHVILLE (CelebrityAccess) – Mirador the new band co-founded by Greta Van Fleet’s Jake Kiszka and Ida Mae’s Chris Turpin announce their first headlining tour of the US with shows in cities including New York GRAMMY Award-winning Greta Van Fleet founding member Kiszka shares vocal and guitar duties with critically acclaimed co-vocalist and guitarist Turpin of Ida Mae Our live shows will feature brand new songs from our upcoming album The story unfolds…” These dates serve to preview forthcoming music from the band and tickets for all shows will go on sale Friday Fans who were lucky enough to catch Mirador’s initial shows opening for Greta Van Fleet’s Starcatcher World Tour in arenas throughout 2024 can attest to the band’s ability to conjure sky-shaking and boundary-bursting rock ‘n’ roll by invoking spirits of ancient myth and Delta-born blues in one concentrated musical incantation filled out by Mikey Sorbello on drums and Nick Pini on bass & keys stretches the limits of rock ‘n’ roll and showcases the band’s myriad influences and uncompromising vision New Artist Signings detailed information on over 50,000 Entertainers as well as hundreds of thousands of records for venues 2024 is on track to be a record-break­ing year … Get free access to a limited number of articles plus choose newsletters to get straight to your inbox Enter the email associated to with your Endpoints account and we'll send you a one-time login link (no password needed) and we'll send you a link to reset your password The link expires after 24 hours and can only be used once Sign up for free to read a limited number of articles each month Pick what newsletters get delivered to your inbox each week Want unlimited access? Sign up for a premium subscription plan 2024 3:39 PM ESTThe makeshift crosses left for victims of fer-de-lances didn’t rattle me much The aggressive vipers thrive in the jungles of northeastern Guatemala and sometimes lay camouflaged along the trail we were following but I figured I could spot their vivid yellow skin if I paid attention I didn’t worry about the swarms of ticks I didn’t sweat the guttural roar of the howler monkeys but I did plenty of sweating: During my trek we experienced 90% humidity and 90-degree temperatures by midmorning the abandoned Mayan empire that until recently was buried under the ravenous jungle of northern Guatemala Few make this journey into these wilds—“up to about 5,000 visitors a year,” many of them European backpackers the archaeologist who serves as director and principal investigator of the Mirador Basin Project and has been working on the site for more than three decades I alone ended up with a face full of netting And every time my face snagged a web strung between the sapodilla trees fist-sized creature wriggling around in my hair Few make this journey into these wilds—“up to about 5,000 visitors a year,” many of them European backpackers the challenges—real and conjured—of getting to El Mirador is part of what makes it so special You can take a bus to Tikal—Guatemala’s better known but arguably over-touristed Mayan treasure—and Mexico’s Chichen Itza but El Mirador is the greatest monument to one of the most robust and brutal civilizations ever to walk the earth: a sprawling metropolis that covers more than 50 square miles That means a 40-mile hike stretching across two or three days depending on how much you stop to take in the sights The good news is that once you’re in there you get an astounding archaeological treasure largely to yourself More than 20 years have passed since I trekked into the Mirador-Calakmul Basin a subtropical rainforest made up of nearly 2,500 square miles set in the dead center of Guatemala’s Maya Biosphere Reserve a region that encompasses the Peten region of northern Guatemala and southern Mexico a team of more than 40 archaeologists and specialists with up to 400 workmen led by Hansen has uncovered buildings and other features of the Maya heartland in 56 ancient cities The summit of Danta pyramid at El Mirador is one of the largest ancient structures in the world it may have been the world's largest pyramid One is that it’s still an incredible journey to get there and back The second is that although the archaeological site and the tropical rainforests around it were officially protected in 2003 as Mirador Basin National Monument an array of outside threats remains—from narcos none of these factors has made the site unsafe for tourists (more on that below) El Mirador offers up one of the last great adventures in the Western Hemisphere The question isn’t whether you should go The question is how soon you can get there El Mirador is the greatest monument to one of the most robust and brutal civilizations ever to walk the earth you get an astounding archaeological treasure largely to yourself.  When he appears on a zoom call from his office in Idaho recently describing one of his critics as “an absolute idiot.” Since my trek his organization has invested $23 million on the basin—some of it on year-round security allows researchers to “peel off the jungle” and see everything underneath. The $1 million research project revealed a far larger and more advanced society than previously thought As many as a million people once lived in this vast network of communities In the summer of 2024 there were 19 major excavations going on most covered by polycarbonate roofs installed to protect delicate art from ultraviolet rays and rain with 400 field workers on site and more doing laboratory analysis Much of the field research takes place from June through August when regular rains provide water that would otherwise cost huge sums of money to truck in Much of the rest of the year Hansen travels to raise money and prepare publications “It’s the largest project in the history of Guatemala,” he says Summit structure of a Late Preclassic pyramid known as Structure 34 or the Jaguar Paw Temple on the southern side of the Tigre Group at El Mirador after excavation and consolidation As many as a million people once lived in this vast network of communities.  The area’s southern limestone cliffs are the last place on the planet with viable populations of the orange-breasted falcon To create the first cultural and natural historical sanctuary in Latin America while maintaining the jungle wilderness That last part—which means no roads and no airstrips—is key It may be critical to the site surviving longer than the Mayans did Richard Hansen beside a massive Ceiba tree—a sacred tree of the Maya—in the Mirador-Calakmul Karst Basin.  History Brought to LifeThere aren’t many places you can go where history is literally being excavacated before your eyes The work during our visit involved the temple of the 13th Mayan king A giant jaguar paw adorned the outside of the temple which has since been revealed to include nearly intact stucco masks with inscriptions you’ll have a wide array of choices and should plan enough time to see both the newly restored sites and the hall of fame locations In the latter category is La Danta pyramid It’s one of the world’s largest pyramid complexes by volume it’s likely that Danta was the largest monumental structure in the world Hansen’s team calculated that it took as many as 15 million man-days of labor with 12 men carrying each block of cut stone weighing about 1,000 pounds Figurine fragments from the Trogon Group at El Mirador provide portraits of the earliest occupants at the site between 1000 and 800 BCE Don’t make what Hansen calls the common mistake of climbing La Danta and then forgoing a visit to the Tigre Complex which sports its own pyramid that soars to 180 feet and covers an area six times larger than the more famous Temple IV at Tikal Hansen and his researchers discovered skeletons pierced through the ribs through the ribs with obsidian arrow points possibly the unlucky participants in an Early Classic period battle that cleared out the last of the abandoned capital In that same vicinity is Structure 34 or Jaguar Paw Temple which features a stairway lined with remnants of ancient masks that may have been as much as 10 feet high Also visible are the silhouettes of the Monos and Leon pyramids part of the administrative complex known as the Central Acropolis which comprise some of the oldest and largest clusters of public architecture in Mayan civilization Hansen points current visitors to newly restored Cascabel complex—one of the major groups of buildings on the northern side of the west complex which he describes as having “beautiful The buildings are made of large blocks of limestone slathered in layers of lime stucco which was originally painted The main buildings generally feature central stairways decorated with masks of Mayan deities Among the treasures Hansen’s team excavated was a royal throne Hansen plans to uncover and piece together the magnificent Stela 1 a sculpted monument made of red sandstone that he first excavated in 1990 Analysis indicates that it weighs about ten and a half tons and the Preclassic Maya moved it from the original sandstone source at confluences of two rivers in the southern Peten—a distance of more than 68 miles without a single tow hitch Once part of a public ceremonial building in El Mirador's Great Central Acropolis the walls of this structure date back at least 2,000 years go to the northern hub Guatemalan city of Flores and hire a licensed local guide the last village at the edge of the roadless region All tours now follow a route along the ancient causeway system—about 110 miles of ancient superhighways that are up to 131 feet wide—linking major ancient cities in the basin and their satellite hubs Hansen describes this as the world’s first freeway system The guides will bring a team of mules carrying water and camping gear; a cook will help set up and break down camp The trek has clearly improved over the years since my visit Instead of the closed-in jungle I experienced hikers will see Mayan buildings along the way The hike itself is also about six hours shorter although with the additional sights might take longer “If you stop to take pictures and look at animals or snakes or orchids or fungi you’re looking at three days,” Hansen says The best times of year to go are November through February and the vegetation has lost many of its leaves Hansen has proposed the creation of a small tourist train along with carefully managed ecotourist-type accommodations to allow for a sustainable number of visitors This would allow the region to remain roadless and avoid overuse of mules which would turn the trail into a dung-covered minefield and ruin the water supply Carefully exposing El Mirador’s historical treasures to more people will help preserve it And that’s a key element of his work—not just uncovering the astonishing history there Tourist access up the facade of the third level of Danta pyramid at El Mirador The original ancient stairs are observed at the bottom of the image Why not just build a road and let people drive in because of the complex matrix of threats to the region He opines—in language that is characteristically both eloquent and blunt—that any public use of this prized landscape other than ecotourism would be “the equivalent of using the Grand Canyon for a garbage dump.” But other parties who have their own aspirations for the region. Timber companies have already engaged in “excessive logging,” according to the Global Heritage Fund, and are eager to make further inroads into the basin. And the Los Angeles Times reported in 2023 that at least seven groups of illegal loggers were harvesting wood they were selling in Mexico It’s not just that roads allow precious forest to be harvested; it’s that drug cartels are eager to have roads that would allow them to more easily move product north into Mexico Top predators of the Mirador Basin: jaguars and the Morelet and American crocodiles Several threatened or endangered animals here include four other types of cats “The loggers punch roads in to get the logs out and the narcos love that,” Hansen says since there’s so much deforestation to the west of us they can be easily spotted by our spy satellites So they like the idea of these jungle roads put in by the loggers because they can move product without being so easily visible “Their resources are infinite,” he said “and we are just trying to keep up.” Detail of the molded stucco frieze on the facade of a structure that had been converted into a causeway in the Great Central Acropolis at El Mirador The art depicts what is believed to be a key figure in the creation story of the ancient Maya The narcos pay a villager around the Mirador region a few hundred bucks to go out and cut jungle “Then they come in with guns and say get out,’ and they put cattle out there,” Hansen says The cartel will later produce a receipt showing they sold the livestock in Mexico City so the money goes “free and clear” into a bank “It’s rampant,” Hansen says “Wherever I didn’t have guards it’s been totally devastated.” El Mirador's wild landscape is home to about 200 animal species and 300 species of trees in six types of tropical forest Above: snowy egret and spider monkey residents there are the big-business developers—the people who want to build resorts and other properties “They want to put their roads in there,” he says “They want to put their stores in there They don’t want the idea of a wilderness area which we’re trying to do to involve the communities.” The struggle with these forces has made Hansen a target He says his life has been threatened twice His response has been to dig in harder and make important friends the head of Latin American and Caribbean affairs for the U.S hiked into the Mirador Basin with him to explore the idea of helping to install interpretive panels to generate deeper understanding of some of the locations Despite the tectonic collision of various interests Mirador has remained safe for tourists—though at times a group of 150 armed men pushed in Mirador from the north and began logging Hansen says; the government sent in armed forces to flush them out and closed the area to tourists for six weeks Olmec plaque recovered from a trash heap in the Trogon Group of the Tigre Complex at El Mirador An Embattled VisionNot all the assaults on the Mirador Basin project have targeted the landscape Hansen has also found himself at the center of an organized campaign that has portrayed him as an interloper eager to enrich himself and leave local communities out in the cold He characterizes these as misinformation campaigns—people labeling him with what he calls the “imperialist A flyer with the words “Hands off El Mirador Richard Hansen” included QR codes for more information Richard Hansen at the base of the summit structure of Danta Pyramid The two worked together on a National Geographic special called “The Story of God.” calling out “both white supremacy and systemic racism.” The bill ultimately stalled whose grandparents were Mexican and who has gone into personal debt to keep the project afloat says he wants to work with and include local communities in Carmelita and elsewhere and has no interest in getting rich; the Mirador basin is his life’s work He has survived several brushes with fer-de-lances and a near-fatal plane crash that burned the only copies of his master’s thesis He’s not about to be brushed back easily He said his lawyers have considered suing his most virulent critics but the man pulling the strings is a billionaire oil magnate who “will throw you into court and suck you dry before you can do anything.” has written about the concerns of the communities living alongside the wilderness “They have the right to utilize the resources of the forest,” he says “and they’ve built their own tourism—and they do trekking and all that.” How well Hansen’s plan would work remains to be seen and Guatemala doesn’t have complete control of that territory,” Abbott says Getting input from locals on the questions surrounding El Mirador has been harder; I emailed a list of questions to Guatemalan officials from the Wildlife Conservation Society in the region including Program Director Gabriela Ponce Santizo Efforts to reach other prominent conservation and archaeological figures in the region were also unsuccessful but it seems he has as much of a chance of anyone of winning the argument to keep the place wild and roadless “Hansen pulls a lot of influence here,” Abbott says Tourist groups at the summit of Danta pyramid with a spectacular view of the surrounding pristine forest one of the last left in all of Central America El Mirador adventurers can embark on a weeklong trek that includes seven or eight ancient cities John and I and our travel companions clambered up loose rock and dirt using a fixed rope to summit La Danta hoping to catch a sunset from above the canopy a keyhole opened in the cumulonimbi and a beam of golden light poured through and the former glory of the Mayan world unfurled around us as a lumpy green carpet We knew that every undulation was part of the empire that had been buried under the landscape and that much of what was yet to be revealed would likely be astonishing in its historical sweep but the opportunity now exists to get a pretty detailed look at the remains of one of the planet’s greatest early civilizations The feeling settled over me of being in a place that felt unfathomably remote—it took a couple of flights skittery scramble atop of this historic landmark to reach this spot Yet we were less than 1,300 miles from the Texas border To be this close to home and get a chance to see this it should go without saying that anyone trekking into El Mirador should be reasonably fit Getting There: From Guatemala City, the Colombian airline Avianca runs regular quick flights to Mundo Maya International Airport in Flores outfitters provide transportation to Carmelita Find a Guide: There are numerous operators in Flores, but you can book in advance—and with a local outfitter—with the Carmelita Cooperative The operator runs 5- and 6-day El Mirador trips focused on sustainability and ensuring that the community participates in and profits from tourism What to Bring: Comfortable hiking shoes that you’ve fully broken in are an absolute necessity. You’ll also want light clothing that covers your limbs. to protect against insects, plus a hat and sunscreen Most guides provide water but it’s wise to bring some of your own Your outfitter may advise you to bring other supplies but there are plenty of stores in Flores for gearing up Make sure you remember a way to keep your camera charged There’s much you’ll want to photograph By David Howard is the author of two nonfiction books, Chasing Phil and Lost Rights: The Misadventures of a Stolen American Relic 23andMe has notched a re­search part­ner­ship with Mi­rador Ther­a­peu­tics to pro­vide the biotech com­pa­ny with ac­cess to its trove of ge­net­ic da­ta the Grammy-winning queen of Tejano music Selena Quintanilla-Perez was killed by Yolanda Saldivar in Corpus Christi Saldivar ran Selena's fan club and was found to have embezzled over $30,000 from the club She was convicted of fatally shooting Selena in the back when confronted about it.  Selena was often called the Mexican Madonna and was rapidly ascending in the music industry when she died Fans stretched a mile to visit her open casket with over 78,000 signing a book of condolence.    a life-sized statue was forged from bronze by sculptor H.W "Buddy" Tatum as the centerpiece of the memorial Named Mirador de le Flor (Lookout of the Flower) it receives an estimated 30,000 visitors per year and was significantly upgraded and restored in early 2024 with LED lighting and a sound system that plays a selection of Selena's music.  It is at the corner of Shoreline and Peoples St at the entrance to the T-Head that extends into Corpus Christi Bay Parking is available on the T-Head for no charge.  An appropriate memorial dedicated to a well-renowned figure of Campbeltown Two members of the Rolling Stones frozen forever in bronze This rural park in central Wisconsin honors one of the world’s most prominent numismatists This memorial and the seawall that it stands near are powerful symbols of the island’s resilience A monument to one of Croatia's famous freedom fighters A memorial to a 19th-century composer who was known for driving crowds wild A bronze statue to commemorate an Auckland library's beloved feline resident A memorial to the Vicentine who survived and documented Magellan's circumnavigation of the world Broadway Off-Broadway Off-Off Broadway Cabaret Dance Opera Classical Music Minneapolis / St. Paul Connecticut Atlanta Chicago Los Angeles Central New York WEST END UK Regional Canada Australia / New Zealand Europe Asia Latin America Africa / Middle East TV/Movies Music New dates have been announced in New Orleans will expand their headlining tour to 31-dates due to popular demand 2x Grammy award-winning, multi-platinum, Latin superstar Ozuna has officially announced his highly anticipated 2025 European Summer Tour, marking his first tour run since 2022.   Nashville-based platinum recording artist Ron Pope will make his Grand Ole Opry debut on Saturday, May 10th. Earlier this year, Pope completed his “Neon and Glass World Tour” - 28 dates spanning the UK, EU, and the US. I Said I Love You First…And You Said It Back, the deluxe version of Selena Gomez and benny blanco’s first collaborative album, I Said I Love You First, is out now. Additionally, a video for the new song “Talk,” directed by Tony Yacenda. Check it out now! Djo has announced a North American Fall tour, which will include festival performances at Lollapalooza, All Things Go NYC & DC, Soundside Music Festival, and more to come. function closestickysocial(){document.getElementById("foxsocial").style.display="none";}@media(max-width:1024px){.most-popular,.video-row{display:block;margin-top:25px}}Videos and exclusive discounts on tickets to your favorite shows © 2025 - Copyright Wisdom Digital Media, all rights reserved. Privacy Policy The performance report for 2024 released by Tongling Nonferrous Metals Group on March 29 for its subsidiary China Railway Construction Tongguan shows that the subsidiary's total operating revenue for 2024 was 8.027 billion yuan up 0.14% YoY; operating profit was 2.432 billion yuan down 15.15% YoY; total profit was 2.435 billion yuan down 15.06% YoY; and net profit was 1.487 billion yuan (Note: The main reason for the decline in operating profit and net profit of China Railway Construction Tongguan in 2024 was the power rationing policy in Ecuador in Q4 2024 which restricted the normal production and operation of the Mirador copper mine.) The announcement from Tongling Nonferrous Metals Group shows that China Railway Construction Tongguan Investment Co. with copper concentrates as its main product holds 70% of the shares of China Railway Construction Tongguan and China Railway Construction International Investment Co. China Railway Construction Tongguan is an important subsidiary of the company and also an associate enterprise of China Railway Construction Corporation Limited The company plans to disclose its 2024 annual report and the audited performance of China Railway Construction Tongguan for 2024 on April 23 China Railway Construction Corporation Limited plans to disclose its 2024 annual report on March 29 and disclose its indirect share of 30% of the net profit and loss and other comprehensive income realized by China Railway Construction Tongguan in 2024 (Note: This data is unaudited) According to a previous announcement from Tongling Nonferrous Metals Group China Railway Construction Tongguan produced 126,500 mt of copper in copper concentrates the total assets of China Railway Construction Tongguan were 185.877443 billion yuan and the net assets were 93.115247 billion yuan; in 2023 the operating revenue was 80.164924 billion yuan and the net profit was 17.896421 billion yuan (the above financial data has been audited) China Railway Construction Tongguan actually produced 101,900 mt of copper in copper concentrates Tongling Nonferrous Metals Group announced on the evening of March 5 that as of February 28 the company had repurchased 23,578,900 shares through a special securities account for share repurchase by centralized bidding accounting for 0.18% of the company's total shares Huayuan Securities previously mentioned the Mirador copper mine in its research report on Tongling Nonferrous Metals Group stating that the injection of Mirador and the steady progress of the second phase will release performance with a total copper reserve of 1.78 million mt with a total mining scale of 9.47 million mt The average copper production from 2014 to 2017 was 47,500 mt and with the full production of the Shaxi copper mine in 2018 copper production increased to over 50,000 mt with an average production of 54,000 mt from 2018 to 2022 the company completed the acquisition of 70% of the shares of China Railway Construction Tongguan whose core asset is the Mirador copper mine The Mirador project has a copper resource of 7.08 million mt The first phase of the project reached full production in 2021 with an annual production of about 90,000 mt of copper the actual production and sales of copper concentrates exceeded 120,000 mt exceeding the design value by more than 30% The estimated average production cost from 2020 to 2022 was 26,400 yuan/mt and the net profit per ton was 14,000 yuan/mt The second phase of the project is expected to be completed and put into production in June 2025 it is expected to produce about 200,000 mt of copper annually (combined with the first phase) Based on the current net profit of 14,000 yuan/mt it is estimated that Mirador is expected to achieve a net profit of 2.8 billion yuan after reaching full production Litigation risk of the net equity gold of the subsidiary of China Railway Construction Tongguan; risk of metal prices falling more than expected; safety production risk; geopolitical risk To learn more about the dynamics of the copper industry chain, you are welcome to attend the CCIE2025SMM (20th) Copper Industry Conference and Copper Industry Expo, hosted by SMM, which will be held grandly in Nanchang, Jiangxi from April 22 to 25, 2025. CCIE2025SMM (20th) Copper Industry Conference and Copper Industry Expo ~ representatives of upstream and downstream enterprises in the copper industry chain and university research experts will gather together covering the entire industry chain of copper more than 100 exhibition companies will showcase the latest copper processing and smelting equipment and other cutting-edge achievements in the copper industry fully demonstrating the innovation and vitality of the copper industry The conference activities are rich and colorful: the main forum focuses on global copper market trends The sub-forums focus on electrical power transmission and distribution deeply discussing industry hot topics; during the conference there will also be a two-day field trip to 12 representative enterprises in the copper industry with a cumulative production of 1 million mt Share cutting-edge technologies and valuable experiences and promote high-quality development of the industry CCIE2025SMM (20th) Copper Industry Conference and Copper Industry Expo Help you grasp the industry pulse SMM sincerely invites you to gather in Nanchang to gather in the new era of copper and jointly plan new development For queries, please contact Lemon Zhao at lemonzhao@smm.cn For more information on how to access our research reports, please email service.en@smm.cn 43,000+ global companies doing business in the region 102,000+ key contacts related to companies and projects news and interviews about your industry in English © 2025 EmCan Media - Hosted By canaryfone In a dramatic robbery reminiscent of a Hollywood movie five masked men carried out a bold and violent heist at the Claudia jewellery store in the El Mirador shopping centre in Las Palmas on last night (Wednesday) The incident occurred at approximately 9:30p.m. entered the premises and threatened a store employee They proceeded to smash display cases and made off with a substantial quantity of jewellery Eyewitnesses reported seeing the group flee the scene in a white Audi The timing of the robbery appears to have been meticulously calculated It took place after most shops in the centre had closed and during a quiet period as many locals were occupied watching a high-profile Champions League match between Real Madrid and Arsenal This detail has led investigators to believe the crime was premeditated and strategically executed Officers from the National Police arrived at the scene shortly after the robbery and have launched a full investigation While the exact value of the stolen jewellery has yet to be determined the scale and audacity of the theft have sent shockwaves through the local community This latest incident adds to growing concerns about rising crime and violence in Las Palmas de Gran Canaria prompting renewed calls for increased security measures in public and commercial spaces across the city new exhibition 'Drawing modernity - from Fortuny to Tàpies' has opened at the Mirador del Carmen cultural centre in Estepona a collection of 100 works by the most outstanding universal geniuses of art that can be viewed until 23 February which is organised by the town hall and the Mapfre foundation brings together drawings framed in the period between 1864 and 1968 by artists of the stature of Picasso Created by these undisputed figures in the history of art the exhibition is presented as a semblance of the history of art structured in three creative stages It starts with drawings by Spanish artists such as Mariano Fortuny Joaquín Sorolla and Francisco Pradilla y Ortiz Many of them worked outside of Spain and were familiar with the works of masters such as Edgar Degas whose work is also present in the exhibition The presence of Pablo Picasso's creations during his time in Paris are quite significant to the collection as his creations served as a link between the most innovative trends that were developing in the French capital and the art that was being produced in Spain Joaquín Torres García and Francis Picabia dialogue with each other throughout the exhibition to explain about a change of era and a heterogeneous art that includes aspects of the avant-garde movements Many Spanish artists who were active in Paris during the 1920s witnessed first-hand the birth of surrealism a trend to which this exhibition devotes special attention Some of the artists featured in the exhibition were essential figures of the movement Relations between France and Spain resulted in a strong surrealist imprint in Spain which would extend over time and would rank along with other trends until the 1950s the avant-garde movement in Spain began to wane due to preference for melancholic art related to the German realism which is represented in the watercolours of Arturo Souto The echo of the new European realisms in Genaro Lahuerta and Joaquín Peinado the surrealist influence on Julio González in the 1940s the search for the primitive and the pure forms of Ángel Ferrant connect with those other informalist works; some more gestural of which the two drawings that close the exhibition which are part of Mapfre's valuable collection of drawings offer a unique opportunity to admire works of art on paper by the most outstanding artists through a story that aims to show the paths that led to modernity at the turn of the 19th to the 20th century The exhibition can be viewed Tuesday to Sunday from 10am until 2pm and from 5pm to 9pm Comentar es una ventaja exclusiva para registrados Please email if you would like to be allow listed “The journey was unfinished,” CEO Mark McKenna The executives behind autoimmune drug developer Prometheus Biosciences are back armed with more than $400 million to launch their latest venture a biotechnology startup known as Mirador Therapeutics Based in San Diego, Mirador looks similar to its predecessor, which Merck & Co. acquired roughly a year ago for nearly $11 billion Mirador intends to develop drugs for inflammatory and fibrotic diseases the company intends to do so with a precision approach large datasets and tailored diagnostics to identify drug targets and patients who might be most likely to benefit from treatment "The journey was unfinished," said Mirador CEO Mark McKenna Prometheus didn’t “finish the mission” it had originally taken on So he brought many members of the team back together to try to build a company focused on precision therapies for autoimmune diseases leaning on their experience and a wealth of data to develop new medicines for inflammatory conditions of the gut “It’s much broader than what we were doing before,” McKenna said Mirador isn’t saying which conditions it’ll go after first McKenna only revealed that those targets have “strong genetic ties” to the diseases it’s interested in But he envisions advancing multiple new drug prospects over the next 18 months and also indicated the company may do deals to bring in more advanced candidates as well “Speed is the new currency in biotech,” he said “We demonstrated it before and we can do it again.” The company’s Series A round was led by Arch Venture Partners and includes a long list of investors such as OrbiMed It is the largest private financing raised by a biotech startup so far in 2024 and one of the sector’s most sizable Series A rounds in recent years Get the free daily newsletter read by industry experts More than three-quarters of private biotech investment tracked by BioPharma Dive between January and March was distributed via rounds worth at least $100 million which experts believe reflects a strategic shift Despite data pointing to a slowdown in company creation at least four biotech startups have raised seeds or Series A rounds since the start of April Subscribe to the BioPharma Dive free daily newsletter The free newsletter covering the top industry headlines The vision to bring precision medicine to immunology and inflammation brought on a financing avalanche led by ARCH Venture Partners Credit: magicmine / iStock / Getty Images Plus After being bought out by Merck in June 2023 for nearly $11 billion some of the ex-brass from Prometheus Biosciences headed to a spear-shaped peninsula in Mexico surrounded on three sides by white sand beaches and lush tropical flora for some rest and relaxation But playing golf and taking in the sea breeze in the coveted hideaway of Punta Minta wasn’t enough to keep Mark C from getting back into the game of making medicines “The transaction with Merck was bittersweet,” McKenna told GEN Edge and it was the right time to do it… But there was a lot of unfinished business at Prometheus There was a realization that we could all go work for different companies or we could come back together and finish the mission The field of data science is evolving so rapidly About three-quarters of a year after the buy-out with some Prometheus veterans and new additions unveiled Mirador Therapeutics with the vision to bring “end-to-end” precision medicine into immunology and inflammation Behind a $400 million Series A and their proprietary platform Mirador plans to leverage open-source human genetics data and cutting-edge data science will enable the company to file for investigational new drugs (INDs) by 2025 “We believe that based on our experience in this category we have a unique vantage point,” said McKenna which directly translates to viewpoint in Spanish and Jordan Zwick will join McKenna at Mirador Therapeutics in San Diego who previously served as a professor of medicine and chief of the division of gastroenterology at the University of California for ten years and co-founded Santarus and Shoreline Biosciences that surface consisted of a clinical database and associated biobank exclusively licensed from Cedars-Sinai Medical Center It included more than 200,000 samples linked to extensive clinical data from 20,000+ patients collected over 20 years the problem with that is that technology changes is realizing is that sequencing techniques and data science are evolving so quickly and we need them to continue to invest in democratizing data and sequencing patients for all you do at the UK Biobank and other places because that allows for innovation I don’t believe the data itself is what’s proprietary The technologies allowing these data sets to be interwoven and translated more rapidly than ever weren’t available months ago.”  Mirador’s scope of indications will go much broader than just inflammatory bowel disease McKenna said Mirador is building a data cohort that straddles the disease areas they’re interested in—gastrointestinal tract and skin diseases—from a combination of open-source data and proprietary academic partnerships end-to-end means Mirador will discover and validate genetic associations with immuno-fibrotic diseases identify novel therapeutic targets and optimal target-target pairs for potential combination therapies and stratify heterogeneous patient populations for precise clinical development “No one’s been able to do this before,” said McKenna “We can put this on steroids and move the field further It’s not the beginning but certainly not the end either.”  McKenna said that he’s learned several lessons none more important than properly managing and stratifying risk This is particularly applicable to committing to using a single therapeutic modality McKenna said that Mirador will not be afraid to try novel approaches from a modality perspective but it will not be at the core of what they do “If you think about the evolution here… [In the early days you started] with an entrepreneur or scientist with one idea and a biased binary outcome,” said McKenna “Then we shifted to this platform-focused idea: create all this data and then ask We are focused on and have expertise in biologics But we’re agnostic to what it is once it’s in the clinic and we will have approaches with biologics working on targets that we find interesting and can be best-in-class You have got to think about this for stratification very carefully.”  The massive $400 million round of funding began through discussions with six investors some of whom had previously worked with Prometheus; some were new relationships “I wanted to work with people who had a big vision for doing transformational stuff and had a track record doing so and I’m not sure you could have found better leads than ARCH [Venture Partners] “Each of them brings different things to the table [co-founder and managing director] Bob Nelson has big visionary ideas [Managing director] Kristina Burrow understands how companies operate You have OrbiMed’s public-market understanding You have Fairmount and their ability to build companies like Fidelity—when was the last time Fidelity entered a Series A McKenna said the $400 million will go to multiple programs It will allow Mirador to in-license external innovation that would benefit from our platform We want to raise $400 million,” said McKenna This is more dilution than necessary in the early days and build a pursuing medicine engine that people just haven’t been able to do.” McKenna also said that Mirador will engage in external innovation finding programs and companies that benefit from its platform and know-how to accelerate the company’s pace and you see a lot of companies spending years and years to figure it out and burning a lot of cash to get there,” said McKenna “One of the most remarkable things about the journey from Prometheus was that and the goal was never to build something to sell—the goal was to build a great company If we build a great company and focus on inputs That’s exactly what we’re doing here [at Mirador] and it’s not about the money; it’s about what kind of impact we can actually have.”  Copyright © 2025 Sage Publications or its affiliates including those for text and data mining and training of large language models The company will leverage its Mirador360 engine to develop treatments for immune-mediated disease Mirador Therapeutics has announced its launch after securing more than $400m from leading life sciences investors The US-based company will focus on developing precision medicines for immune-mediated inflammatory and fibrotic diseases Mirador is headed by a group of former executives from Prometheus Biosciences and aims to transform the treatment landscape for immune-mediated diseases is at the core of its strategy to rapidly progress multiple programmes ARCH Venture Partners led the financing for Mirador with significant early investments from OrbiMed and Fairmount The funding round also saw contributions from a consortium of top-tier investors including Fidelity Management & Research Don’t let policy changes catch you off guard Stay proactive with real-time data and expert analysis Mirador will focus on the development of precision medicines using Mirador360 which fast-tracks the process by leveraging advancements in human genetics and data science Mirador360 can analyse millions of patient molecular profiles This analysis aids in discovering and verifying genetic links to immuno-fibrotic ailments identifying new therapeutic targets and understanding interactions between targets potentially leading to the development of combination therapies The platform enables the company to create diagnostics and stratify patient populations we envision a bold new era of precision medicine for immune-mediated inflammatory and fibrotic diseases driven by speed and superior development accuracy “The industry has only scratched the surface of utilising advances in human genetics – coupled with exponential progress in machine learning – to accelerate the development of precision therapies for patients who need them the most leading healthcare investors and proprietary data-driven approach we aim to create a leading precision medicine company at scale to provide important new treatment options for patients.” Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network arguably the hottest food-and-drink thoroughfare in New York state right now When you walk into Mirador, a spectacular new Spanish-inflected spot in Kingston you find yourself flanked by an alluring series of bone-white architectural arches It might give you a vaguely Jonah-esque sense of being sucked into the belly of the biblical whale But by the end of a wildly memorable meal there one that had been swimming through pristine waters my insides gratefully accepting an abundance of outstanding seafood It would be fair to say that at my table in Mirador — and I won’t ask to be excused the following pun — I had a whale of a time with some dishes larger than others and prices running $7-$28; cocktails Info: 845-514-2983 and miradorkingston.com; reservations via Resy.com but what if you don’t happen to like fish or various creatures that need to be extricated from their shells I didn’t even get to all the pork on offer ending their parade of tapas by splitting the attractive-looking jamon burger They made certain sounds suggesting they were quite happy with their jamon Mirador is located in midtown Kingston on Broadway (arguably the hottest food-and-drink thoroughfare in New York state right now) in a space that formerly housed Lunch Nightly Spanish for “lookout” or “viewpoint,” describes itself as an Andalusian-inspired lunch and dinner spot and coffee bar It also calls itself a “tabanco,” a regional word for a tavern that might sell sherry straight from the barrel a place to gather and enjoy a drink and a few bites to eat Having soft opened a whisper before Christmas, Mirador began offering a full dinner menu in early January. My colleague Maria M. Silva covered the news of its arrival as well as another spot serving Spanish fare Maria had a particular interest in the topic: she was brought up in Girona Spain — about an hour from Barcelona — and her family is originally from Andalusia MORE: Spanish tapas are having a moment upstate would you listen to my opinion on the Andalusian-inspired food at Mirador when the Times Union employs a writer who spent the first 17 years of her life enjoying Spanish tapas which is why Maria and I have been sharing our thoughts via email on the two meals we ate at Mirador but la magia está en los pequeños detalles (magic is in the small details).” An admission: I’ve eaten pan con tomate in Spain numerous times  — it’s often handed out for free at the beginning of a meal — and never particularly loved it That staple of tapas restaurants: patatas bravas topped with spherical dabs of aioli and a shower of tarragon leaves which Maria found “fun and garlicky.” I also loved the dish’s presentation potatoes stained red by their distinctly smoky paprika The jumble of spuds lurk beneath spherical dabs of aioli each one looking like a sunshine-colored beanie everything topped with a shower of tarragon leaves Maria had the prawns and told me they “tasted like the ocean and not like the bottom of a freezer.” I’ll be opening wide for the prawns on my next visit And while I was washing down my food with sherry and Spanish wine Maria was delighted to discover that Mirador offers Estrella Damm beer “just like at home,” explaining to me she felt “transported 4,000 miles away across the ocean Even café con leche was served in a glass instead of a mug That’s such a seemingly insignificant detail but it showed me that they’d really taken the time to pay attention and showcase the small pleasures of Spanish culture.” The “they” to whom Maria refers are co-owners Harry McNamara and Nick Africano. I was keen to try Mirador’s sherry offerings because Africano is an expert who’s spent a decade importing the drink to the U.S. and founded the subscription sherry club, Enramistas Mirador’s regular menu boasts six sherries by the glass and 22 bottles which was light and quaffable; the palo cortado bright with notes of orange zest; and the oloroso which brought to mind caramel and nuts with a kiss of salinity Sherry matches stupendously well with Mirador’s cuisine The bacalao (salt cod) was not only pleasing but one of the prettiest plates of food I’ve eaten in a while a mound of cod and tiny diced fingerlings surrounded by a pool of ajo blanco (a creamy tangy soup/sauce,) speckled with dime-sized blobs of olive oil Bacalao (salt cod) served with tiny diced fingerlings surrounded by a pool of ajo blanco The hits kept coming. The tosta matrimonio is a phenomenal slab of chewy Rising River Bakehouse bread made tastier still with smoked butter and topped with Don Bocarte anchovies I’d wager it could turn anchovy haters onto the pleasures of this divinely salty fish mail them to me — I bet they’ll still taste good after several days in a cardboard box Tosta matrimonio: chewy Rising River Bakehouse bread topped with Don Bocarte anchovies and a scrim of smoked butter My final savory dish was grilled mackerel with turnips and an astonishing toasted rice velouté — creamy The mackerel was one of the cleanest-tasting pieces of fish I’ve ever had Mirador’s mackerel tasted of a sea breeze kissed by a beach fire Grilled mackerel with turnips and a creamy The mackerel is one of the cleanest-tasting pieces of fish our critic has had it would have felt rude not to have ordered two The “sherry berry” was a bowl of marinated blueberries beneath a thick layer of cream but it was outshone by the “flan panna cotta,” a mash-up of two excellent things the custard smoother than a Sinatra serenade and perfumed with honey and cinnamon (But can I put in a bid for renaming it “flanna cotta?”) a bowl of marinated blueberries beneath a thick layer of cream which is what it says it is and tasted ethereal remembering the pleasure of that final dessert has now left me a little woozy so I think it’s time to hear from Maria again “Mirador has taken tapas — a comfort food that can sometimes be predictable and stereotyped beyond belief — and turned it into something fun approachable and a beautiful homage to Spanish food and culture Although I have a feeling it sounds better in a Spanish accent