Our Standards: The Thomson Reuters Trust Principles., opens new tab , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved For the last 10 years, the architect has overseen the UFMG team in the planning of the Belo Horizonte Metropolitan Area A native of Conselheiro Lafayete, with Portuguese and indigenous ancestry, he sang bass at UFMG’s Ars Nova choir, and later with the Glee Club, the men’s chorus at UCLA, while getting his PhD. Monte-Mor has a son, psychologist Diogo, and a grandson, who both live in Portugal. He talked to Pesquisa FAPESP in June at UFMG. We wanted the planning to serve everyone: the government, civil society, and businesses Rodrigo Lima / Wikimedia commons Belo Horizonte, featuring Lake Pampulha and Mineirinho ArenaRodrigo Lima / Wikimedia commons The expansion of the urban fabric toward the country also brings the beginnings of polis, politics, and civitas, or citizenship Personal archives In Machadinho do Oeste holding a pente-de-macaco (Apeiba tibourbou)Personal archives I visited a colleague in India and saw the state of Kerala a quality of life equivalent to that of Europe where rural and urban spaces have already blended completely A lot of people are discussing these phenomena asked to translate and publish two of my works in a compilation he published in 2014 Implosions/Explosions: Toward a Study of Planetary Urbanization which has brought high visibility to this debate One of the texts had come out in 1994 in a book organized by geographer Milton Santos [1926–2001] This 1994 work of mine was the first to be more widely publicized out of the ones in which I claimed that extensive urbanization would necessarily correspond to extensive naturalization I gave a presentation at a University of São Paulo (USP) seminar organized by Milton Santos My opponent in the debate was a famous geographer it makes no sense.” Milton supported me: “Don’t worry about the criticism you have to dare to think.” At the time people didn’t understand what I was talking about Kids who live in apartments even have worm farms I went all the time to examine the urbanization processes in Rondônia during a project with colleagues from NAEA [Center for Advanced Amazonian Studies at the Federal University of Pará] We followed the settlers’ entrance into collective reserves Every July we took 15–20 students and spent the whole month interviewing everyone a man from Paraná said to me: “When I first came here I was scared of the forest; I couldn’t wait to cut it all down Now I go back to Paraná and I’m sorry to see what it’s like over there and I see that our wealth here is the forest.” They are learning how to plant underneath the trees of the forest I examined the nature of the urban in three extractive reserves: one on dry land in Acre; one on the riverside in Pará; and the marine reserves on the coast of Pará The way residents see the urban space depends on their relative position and support for their production; they do not want urban services because they claim that with them comes the “bulixo,” meaning small taverns or “botecos,” as they call them they have better control over this interaction © Revista Pesquisa FAPESP - All rights reserved. Text description provided by the architects. Located in Haras Larissa, in the interior of São Paulo, Casa PAR has 524m² distributed on a 2169.40m² plot of land. © FelcoThe main access is through the social block, entering the hall that organizes the other rooms of the house - a half bath; a support area with laundry, bathroom, and bedroom; and a living room overlooking the outdoor area. © FelcoThe main hall also provides access to the intimate block through a sturdy wooden door that symbolizes the separation of the two volumes of the house. Upon entering, the circulation to the four suites and master suite is illuminated by natural light from openings in the wooden roof - marking the passage of time within the habitat. The concept of Casa PAR intertwines the simple and the sophisticated, traditional vernacular and contemporary, balancing two universes to tell the narrative of the current countryside house. The architecture provokes this coexistence and the curation of materials reaffirms it - the social wing presents cold coatings like stone and metal, and the intimate wing warm coatings like wood. Natural materials were tailor-made to promote the sensation of calm, serenity, and belonging. © FelcoIn the outdoor area, the house is surrounded by wooden decks and concrete steps for access to each of the suite openings, living room, kitchen, and others, and a 44m² pool. Casa PAR is inspired by the countryside and designed for contemporary living, aimed at valuing traditional vernacular architecture with current everyday uses. You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email Metrics details Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge More than 90% of the cases invade the muscular layer more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC This prospective study included 21 dogs with spontaneous bladder UC Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria We had no deaths during ECT or in the immediate postoperative period Most dogs (19/21) developed mild adverse effects whereas two dogs developed ureteral stenosis Complete response (CR) was achieved in 62% of the cases (13/21) while partial response (PR) was achieved in 24% (5/21) The median survival and disease-free survival times were 284 and 270 days Overall survival was significantly better in the dogs who achieved a CR These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease This study aimed to evaluate the safety and feasibility of ECT as a local treatment for canine bladder UC We also evaluated the local antitumor effect of the therapy paving the road for future clinical trials in human medicine Complete blood count and biochemical profile performed prior to ECT were in normal range for all the included dogs Twelve of the 21 dogs (57%) underwent one ECT session the interval between sessions ranged from 33 to 70 days and was individualized for each case depending on the response to the treatment The mean interval between the first and second session was 52 days and between the second and third session was 45 days Intraoperative histological photomicrograph by frozen section of bladder UC (case #15) (A) Central region of a papillary UC (toluidine blue). (B) Muscular (white arrow) and serosal (black arrow) layers of the bladder free of neoplastic infiltration (toluidine blue). (C) Lymphatic infiltration of tumoral cells (black arrow) (toluidine blue). Case #5 (A) Tumor exposure with eversion of vesical mucosa following cistotomy Ultrasonographic evaluation of the urinary tract of case #17 (A) Moderate to severe pyelectasis of right kidney; renal pelvis measuring 2 cm megaureter) due to stenosis of the ureteral ostium Life-threatening abnormalities on blood tests were detected during follow-up in four dogs, who died within 34 days (cases #3, #12, #13, #21) due to causes unrelated to the ECT. These alterations included anemia, thrombocytopenia, leukocytosis, and elevated levels of serum creatinine and BUN, and were associated with their respective causes of death (Table 2) According to the quality of life questionnaire filled by the owners and the oncologist’s clinical evaluations all 19 dogs who developed mild adverse events had no relevant negative impact on their quality of life the two dogs that developed ureteral stenosis manifested a more severe alteration of their life quality including a higher level of pain and changes in behavior this negative impact on the quality of life was transitory lasting until surgical resolution of the complication The procedures were well tolerated by the dogs who completely recovered their baseline quality of life score according to subsequent assessments two dogs developed local progression of the tumor inside the bladder (case #1) and to the prostate (case #18) and the other dog developed distant metastatic spread to the lungs (case #8) Sixteen dogs died of causes unrelated to the disease or the ECT, which included mainly other types of neoplasia (4/16; 25%), and chronic kidney disease (3/16; 18.7%). The remaining causes of death included ehrlichiosis, sepsis, pulmonary thromboembolism, peliosis hepatis, perforated gastric ulcer, acute kidney injury and cardiomyopathy (Table 2) It was not possible to determine the cause of death in one dog Necropsy was performed only in two dogs (case #3 and #4) In the remaining cases it was not performed due to owners’ refusal and the cause of death was presumed according to the clinical condition and blood and imaging tests Local response assessment by ultrasonography of case #15. (A) Bladder tumor before the first ECT session. (B) Complete tumor remission after one ECT session. Local response assessment by ultrasonography of case #17 (A) Bladder tumor before the first ECT session (B) Partial tumor remission after two ECT sessions The local response was not associated with sex (Fisher’s exact test p = 0.4) or tumor location (Fisher’s exact test most of them achieved it in one session (77%) Among the dogs who required two sessions (15%) a median of 56 days (range 22–71) passed between the two sessions For the dogs who required three sessions (8%) a median of 43 days (range 33–60) passed after the second session Microscopic neoplastic foci were identified by additional surgery in five dogs who had a CR the owners of the remaining eight dogs with CR refused any additional surgery no additional ECT sessions were performed because of the owner’s refusal The median duration of response (DOR) was 270 days (average 371, range 30–981 days). Tumor recurrence occurred in five dogs (38%) in which CR was achieved, and the median time to its development was 257 days (average 354, range 170–790 days) (Table 2) At the end of the study, two dogs remained alive, one with CR and the other with tumor recurrence. Among the 19 dogs who died, six (31.5%) died without tumor evidence (CR), 10 (52.6%) died with macroscopic or microscopic tumor evidence, and three (15.7%) died before the period of response evaluation (Table 2) (C) Survival time by the number of ECT sessions performed (Log-rank test (D) Survival time when a complete response was achieved (Log-rank test Considering the anatomical characteristics of the urinary bladder as well as the possible side effects associated with ECT the present study evaluated the safety and feasibility of this technique for the treatment of bladder UC in 21 dogs the local ECT antitumor effect was preliminarily assessed Shih Tzu and Poodle (38%) were the most affected breeds in this study with no occurrence of the most known predisposed breeds This fact may be related to differences in racial distribution between the canine population in Brazil the process of cell death caused by ECT occurs in any tissue where cancer cells infiltrate ECT application in bladder tumors that infiltrate the serosa would entail significant risks of bladder rupture and uroperitoneum as the serosa is the last layer of the bladder lining the non-involvement of serosa was a crucial inclusion criterion in this study only four cases showed lymphatic invasion and due to this small sample size it is difficult to determine whether this feature affected the OS of the dogs None of their dogs developed any of these complications The development of this condition may be due to transient inflammation and edema in the bladder mucosa leading to nerve stunning and involuntary muscle spasms Two dogs (9.5%) developed ureteral stenosis at 56 and 69 days after the second ECT session (VCOG = 3) They were treated surgically by placement of a “double-J” stent with good tolerability Ureteral stenosis might be attributed to scarring fibrosis resulting from tumor death as the amount of fibrotic tissue increases we believe that the tumor proximity to the ureter could be a risk factor for the development of ureteral stenosis Additional care should be taken in those patients as well as more frequent clinical and imaging reassessments the rate of distant metastasis at the time of death was 49% among 80 dogs with bladder UC This discrepancy could be attributed to the earlier stages of the disease in the present study Another hypothesis may be attributed to the potential efficacy of ECT in eliminating cancer cells at the primary tumor site future studies including a control group could confirm this The remaining 16 cases died from causes unrelated to UC The dogs included in this study were old with multiple comorbidities The treatment of bladder cancer provided very good results and prevented the death of the animals from the disease continued progressing and ended up provoking their death The case which died due to acute kidney injury (AKI; case #12) had a previous history of chronic kidney disease the renal panel (BUN and creatinine) and urinalysis as well as the dog was in good general condition We believe that this dog may have developed an acute injury to the kidneys due to an aggravation of the previous CKD related to the use of NSAIDs during the postoperative period Although AKI is not reported as a complication of ECT caution should be taken with elderly dogs with some grade of kidney disease Lymph node involvement was assessed through fine-needle aspiration and intraoperative cytology Even apparently normal nodes were evaluated Although histopathology is the gold standard for definitive diagnosis of lymph node metastasis we elected cytological evaluation because it is faster either for sample collection or intraoperative evaluation and it is associated with lower intraoperative complication rates It is important to note that all dogs who had regional lymph node metastasis were also staged as T2 with serosa involvement or T3 during intraoperative evaluation reported the occurrence of abdominal wall metastasis during a follow-up at 121 and 230 days respectively We had longer follow-up times of around 1000 days none of the dogs in the present study developed this complication after cystotomy and ECT We attribute this to the careful manipulation of the bladder and to the fact that the whole bladder was treated with ECT For the assessment of local response, ultrasound images sections obtained from each examination should be standardized, for ideal comparative purposes. However, as a limitation of the study, we could not standardize the cross-sections of the images depicted in the ultrasound report for some cases, as we can see in Fig. 4A (transverse section) and 4B (sagittal section) dogs predominantly in stage T2 were included as were in this study the TNM stage of the dogs was not reported it is important to consider two main points in the present study ECT was not combined with any other adjuvant therapy the majority of cases (76%) had tumors located in the bladder trigone Tumors in this location naturally have a worse prognosis and shorter OS because of the complex surgical approach tumor location was not correlated with DFS and survival time in the present study the use of single-agent toceranib phosphate in dogs with UC resulted in a clinical benefit of 86.7% as we had intraoperative histopathological analysis we indicated additional procedures even when macroscopic CR is achieved according to our experience and considering the time to tumor response as an individual and variable factor it is possible to determine the preferable interval between ECT sessions to range from 45 to 60 days ECT is a safe and feasible therapy for dogs with T1 and T2 bladder UC without serosal The therapy was well tolerated by the dogs providing significant local control of the disease along with a good quality of life the results obtained in this study are promising; however Further prospective studies should be conducted to evaluate the efficiency of ECT in bladder tumors using a larger sample size of dogs and performing comparative analysis between different treatment groups (ECT vs Although the primary aim of this study was to evaluate the safety and viability of ECT in canine bladder UC one of its limitations is the lack of a control group comparing ECT with conventional treatments for bladder UC The absence of a control group is due the fact that all dogs presented with bladder UC Another limitation of this study is the small number of dogs requiring two the comparison of the survival times among these groups is difficult A case series with more dogs is needed to address this aspect we have that most of the cases were in stage II it is an early stage and surgery can provide good results when performed correctly we have to consider that dogs with serosal due to our knowledge and experience with ECT we anticipated serious complications if we proceeded with the treatment of those cases If the whole thickness of the bladder wall is replaced with tumoral tissue then no normal tissue is present in that precise point a perforation in the bladder wall can occur producing the leakage of urine to the peritoneum we consider it is mandatory to refrain from treating with ECT cases where serosal invasion is present Future studies are needed to contrast the results of ECT with other local therapies This prospective clinical study was performed in accordance with the relevant guidelines and regulations of the Brazilian National Council for the Control of Animal Experimentation (CONCEA) and was approved by the Ethics Committee in the Use of Animals of the São Paulo State University “Júlio de Mesquita Filho” (UNESP) School of Agricultural and Veterinarian Sciences Written informed consent to perform the treatment was obtained from all the dogs’ owners All experiments were performed in accordance with relevant guidelines and regulations Cases eligible for inclusion in the study had to meet the following criteria: (1) histopathological diagnosis of bladder UC; (2) T1 or T2 stage (without tumoral invasion of the bladder’s serosa layer); (3) absence of urethra and/or ureter involvement; (4) absence of regional and distant metastasis; and (5) rejection of the owners of other treatment modalities It is important to highlight that the invasion of the serosa the urethra and/or the ureter was an exclusion criteria for the study as there is a high risk of perforation after ECT in these cases All procedures were performed under general anesthesia Germany) was administered intravenously at a dose of 5 mg/kg Brazil) was used to maintain the anesthesia incisional biopsies were performed and an intraoperative histopathological evaluation was performed to minimize tumor cell spread and subsequent implantation in neighboring organs the following criteria were met: (1) careful manipulation of the bladder; (2) exchange of surgical instruments and gloves after contact with the tumor; and (3) in the case of bladder eversion contact of the inner bladder wall with any other intra-abdominal structure was avoided Intraoperative histopathological evaluation was performed using frozen sections This technique comprised the steps of macroscopic analysis of the samples freezing with compressed CO2 and obtaining sections approximately 5 µm in thickness in a portable freezing microtome (Leica) The sections were then stained with toluidine blue and analyzed under a light microscope (Nikon YS2) Intraoperative evaluation allowed the assessment of regional lymph node involvement, tumor diagnosis, degree of tumor infiltration on the bladder wall, and consequently, the definitive inclusion of the dogs (Fig. 1) Presence of inflammation and lymphatic invasion were also evaluated Each train of pulses consisted of eight square bipolar pulses The pulses were delivered using a 6-needle electrode which consisted of two sequences of three needles with 5 mm distance between contralateral needles and a 3 mm distance between ipsilateral needles the dogs were hospitalized with a urethral catheter for at least 48 h Anti-inflammatory drugs and analgesics used during hospitalization included tramadol hydrochloride (4 mg/kg/BID) and meloxicam (0,1 mg/kg/SID) Dogs were discharged with domiciliary prescription of tramadol hydrochloride (4 mg/kg/orally/BID) and piroxicam (0.3 mg/kg/orally/SID) for 3 more days The treatment period was individualized for each case and was determined as the period between the day of the first ECT and 30 days after the last ECT session regular follow-up was scheduled every 60 days for the first 6 months and every 90 days until a year after the treatment which is considered the observation period and abdominal ultrasonography were performed in each visit Chest radiographs were obtained every 3 months to assess the presence of lung metastasis the cause of death was presumed according to the dogs’ clinical condition and blood and imaging tests The questionnaire contained 17 items related to observable behaviors commonly perceived by owners and was organized into four proposed factors: vitality Each item was arranged as a sentence that described a common behavior followed by a numerical analog scale (0–7) The owner was asked to circle the number of days in the previous week the behavior occurred Additional information obtained by the oncologist and owner at each follow-up visit was documented in the dog’s medical records the local response was assessed 30 days after each ECT session and the final local response was determined at the end of the treatment period when no more ECT sessions were needed or the owner rejected them New ECT sessions were performed when macroscopic evidence of the tumor was identified during ultrasound evaluation at least 30 days after the previous session consent for an additional surgical procedure was requested from the owners in order to confirm the absence of residual microscopic disease If neoplastic foci were identified on intraoperative evaluation Survival time was defined as the time between the first ECT and death DFS was calculated only for cases who achieved CR It was defined as the period between CR achievement and the day of local or distant relapse PFS was calculated only for dogs who achieved PR or stable disease and was defined as the period from PR achievement (or from the first ECT for stable disease cases) until progression or death the DOR was calculated for all dogs who achieved CR or stable disease and was defined as the period between the final local response achievement until local or distant relapse/progression were reported and redirected to other therapy Dogs who developed progressive disease within the treatment period were excluded from the study and were directed to other treatment modalities Statistical analyses were performed using MedCalc version 14.8.1 To analyze the influence of different factors on survival and disease-free survival and significance was assessed using the Log-rank test Fisher’s exact test was performed to determine the influence of different factors on the achievement of the response Statistical significance was set at p < 0.01 The data generated during this study are available from the corresponding author on reasonable request De Brot, S. et al. 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J. 205, 217–225. https://doi.org/10.1016/j.tvjl.2015.01.017 (2015) Download references The authors would like to thank for Coordination for the Improvement of Higher Education Personnel (CAPES) for funding the research and the owners of the dogs participating in this study The funding was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior School of Agricultural and Veterinary Sciences São Paulo State University (UNESP) “Júlio de Mesquita Filho” Laís Calazans Menescal Linhares & Andrigo Barboza de Nardi Federal University of Santa Catarina (UFSC) Instituto Universitario de Ciencias de la Salud conducted data collection and analysis and prepared the paper critically revised the manuscript for important intellectual contents and approved the final version The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-023-45433-4 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. 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PortugalChevron but he feels most at peace in the countryside You can see the edge of the empty land,” he says Last year you moved from Berlin to rural Portugal I arrived in Portugal without any knowledge of the country and my father received a medal from the president of Portugal many years ago which he presented to him at the Portuguese embassy in Beijing I had lived in Berlin for the last five years before moving here but in the end the Berlin winter is too long And I don't like that the days are always gray The first thing I noticed was all the sunshine Nature is so generous; it gives you everything for free I saw this house and told the owner I wanted to buy it One Saturday I went to the market in Montemor-o-Novo “Why did you choose Montemor-o-Novo?” When people choose a place But in my case I'm going by my intuition Now that I've lived here for a year during this pandemic Ai Weiwei at home in the Portuguese village of Montemor-o-Novo there is a huge tidal pool with all these crabs What are some other highlights in Alentejo Évora is a very beautiful city: the architecture I really like markets in the places that I go here because they reflect the history of the area You see a lot of things that are no longer used What do you think of the work of Portuguese architects like Álvaro Siza Vieira I have been following his architecture for a long time To give someone under the age of 30 that freedom is incredible With “Rapture,” you collaborated with heritage tile house Viúva Lamego in Sintra I have had a great interest in porcelain and ceramics since the 1970s My compatriots make super-fine-quality porcelain So here I saw the tiles and understood that there is tradition I always try to integrate different kinds of language to give tradition a new interpretation This article appeared in the March 2022 issue of Condé Nast Traveler. Subscribe to the magazine here. up-to-the-minute voice in all things travel Condé Nast Traveler is the global citizen’s bible and muse We understand that time is the greatest luxury which is why Condé Nast Traveler mines its network of experts and influencers so that you never waste a meal or a hotel stay wherever you are in the world 10% off products and services for Chapman University students and faculty with school ID Junior Anna Montemor transferred to Chapman at the beginning of the season and has made an immediate impact on the field establishing herself as women soccer’s leading scorer At each of these timestamps in Chapman’s 5-1 victory over California Institute of Technology on Oct In securing a hat trick – three goals in just one game – Montemor it may come as a surprise to know that this is just Montemor’s first year at Chapman as a transfer student her success on the field has followed her throughout her collegiate career A junior broadcast journalism and documentary major she spent her freshman and sophomore seasons at Vanguard University in Costa Mesa where she received a scholarship to play soccer she was a 2017 Golden State Athletic Conference All-League selectee. But even with the athletic success she saw at Vanguard the Dodge College of Film and Media Arts at Chapman was always in the back of her mind she began the process to transfer between universities last December ‘You should just see if you can get into Dodge,’ because I really wanted to come here for broadcasting,” Montemor said As both a junior in college and first-year player at Chapman Montemor began this season between the traditional freshman’s profile and a veteran upperclassmen Although assimilating into a new team can be difficult regardless of context Montemor faced an early-season rut on the field that made her transition only more difficult I’d hit the crossbar all the time and could not finish if I can’t score then why am I a forward?’” she said. Yet Montemor quickly sorted her headspace out and got back to the level of success she’d enjoyed previously “As soon as I dropped that and went out and just played I started scoring again – just getting out of your own head and thinking all of the work you put in is going to show,” she said. it took time for Montemor to get to know everyone on the team “That was the best bonding experience,” Montemor said “It was nice to see people out of their element – that really brought us together.” Freshman forward Dani Berch said she admired Montemor’s work ethic; the two have become fast friends as newcomers to the program the elder has acted as a mentor to Berch. so she’s helped a lot with that – motivating me and helping me off the field,” Berch said she tells me that things are going to be OK and that’s the best thing to hear sometimes.” Montemor steps onto the pitch at Wilson Field with more confidence Head coach Courtney Calderon praised her work ethic and positive attitude – a player that can single-handedly push her team to success “She’s super dangerous with the ball at her feet She comes in and plays quite a few minutes for us with no complaints “She pushes the team by her work ethic and her leadership.” where ASU midfielder Lara Barbieri grew up “everybody basically breathes soccer.” Barbieri has been stranded in Brazil since March PHOENIX – As the start of the Pac-12 women’s soccer season closes in Arizona State is without veteran midfielder Lara Barbieri unable to return to the United States because of the COVID-19 pandemic when she flew home after spring break and ASU pivoted to remote learning travel restrictions would be lifted so she could return to Tempe but she may have found a solution: She plans to leave Brazil shortly quarantine in Mexico and then enter the U.S There was a period of time where many thought a 2021 women’s college soccer season wouldn’t happen after it was postponed last fall That changed when the NCAA announced in September that the season would begin Feb its average of 1,000 deaths per day made it one of the countries with the highest amount of deaths A second wave hit in December and the government postponed reopening universities until March “We haven’t seen her since March when the coronavirus began We’ve missed having her personality around the rest of the group and we look forward to hopefully her border opening up again … because she is a great teammate,” Winkworth said Barbieri’s home town is part of the metropolitan region of Campinas and has a population of about 55,000 it is like everyone is a soccer fan,” she said It is there where Barbieri got her beginnings in the sport soccer is made for boys,” she said before adding “I’d rather play with boys than girls because it is a different type of game … So at that time I would rather play with boys.” as there were no girls teams for her age group Barbieri played with boys her age until she was 13 Barbieri played for Associação Atlética Ponte Preta a team in the second tier of Brazilian football Ponte Preta is also the second oldest soccer club still active in the country She also played for Ponte Preta’s crosstown rivals Guarani Futebol Clube She was even called up to play on the U15 and U17 Brazilian national teams so it was a dream to me and it keeps being a dream,” Barbieri said she decided it was time to take her talents to a college in the U.S “I see an opportunity to play soccer at a high level and also study and get a degree,” she said After getting help contacting college programs Barbieri began to make connections at various schools “Lara was one that was actually found through an agency when I was at my previous institution at South Alabama I saw her then and we were talking to her briefly (there) and then I came here (to Arizona State) and we continued those conversations,” Winkworth said Barbieri began her collegiate career at ASU in the fall of 2017 not just moving to a new country and a new city but transitioning to a whole new style of soccer stronger and here in Brazil we are more technical we keep the ball with freestyle,” said Barbieri It keeps the game (at a) very high level.” Although she initially had to adjust to the physical aspect of American soccer her passing ability and skill on the ball shined through Both are important tools for any central midfielder long passes she’s excellent,” Winkworth said of her talents “She’s very good and comfortable in possession of the ball under pressure so you’re happy to give her the ball even with opposing players around her because she’s very comfortable with the ball at her feet.” Barbieri plays the classic style of Brazilian soccer Its beauty can be seen today by such players as Neymar Jr who help keep the Ginga style of play alive one of Arizona State’s veteran midfielders is stranded in Brazil because of travel restrictions but hopes to return before the start of the season in February “Ginga is a blend of Brazilian culture that seeped into the football fields The first ingredient that influenced Ginga was a martial art called Capoeira The second part of Ginga involves the principles of Samba dance Combining these two strong and versatile styles of the Brazilian culture gave birth to the quick-witted swaying and fast-flowing movements of Ginga The style is a dominant flavour of football in the country and focuses on an attack-minded game.” “The attacking flair side of the game … that’s very prevalent in the Brazilian game The area of the game that is not as prevalent in Brazil is the defensive side of the game,” Winkworth said adding Barbieri has focused on the lesser emphasized side since she arrived in Tempe “One area she is working hard at … is the defensive side of the ball Her understanding of how to defend as a midfield player has improved dramatically,” he said ”The strength and conditioning side of the game is very important in the U.S and I think that’s another area she enjoys working with the staff that we have and the facilities that we have that’s another area she’s shown some growth.” Barbieri has communicated with ASU coaches and staff while she’s been stranded and has been given a conditioning plan to follow at home will be Barbieri’s senior year at Arizona State Luckily the journey will not end once she graduates as the NCAA has granted an extra year of eligibility for many athletes because of the pandemic Barbieri said her biggest goal for the 2021 season is to “get into the tournament,” meaning the Women’s College Cup a 64-team March Madness-style tournament to determine the Division I women’s national champion Stanford has won the title two of the last three years But Stanford is not the only challenge in the Pac-12 for ASU A total of eight teams from the conference made the 2019 Women’s College Cup with UCLA and Washington State joining Stanford in the Elite Eight This doesn’t change a thing for the Sun Devils that is what (we have been) looking for the past three years and it would be awesome to end my senior year getting in the tournament,” Barbieri said Arizona State completes upgrades to women’s soccer, lacrosse ‘dream’ fields Along with dealing with all new COVID-19 protocols put in place by the NCAA the Sun Devils will be playing in a newly renovated stadium plans moved forward for renovations to the soccer and lacrosse team fields and the project was completed in September With the new field will hopefully come new success for the program after opening with five straight victories The goal now is to grow from last year’s campaign Assuming Barbieri can make it back in time for the season she will be one of three seniors on the squad looking to lead the young Sun Devils “I’m hoping since March she’s had the opportunity back home to make sure she’s running a lot make sure she is getting fit,” Winkworth said “If she (has) then she can certainly unlock an opposing team’s defense with her vision hoping she can re-enter the country before the season kicks off While entering the United States directly from Brazil isn’t possible because of government restrictions I will have to go through Mexico because for Brazilians to get back in the United States we have to quarantine in another country,” she said recently “I’m looking for a big group of Brazilians that need to go back to the United States.” the Sun Devils simply have to hope they can get a skillful dribbler and veteran presence in Barbieri back to Tempe for the spring season Cronkite News is produced by the Walter Cronkite School of Journalism and Mass Communication at Arizona State University Staff members are listed here Learn more about what we do and how to find our content on our broadcast Find out how your news organization can use Cronkite News content Sign up for daily headlines [email protected] Creative Commons Privacy statement Scott Autten and this is evident in the way many people seek actively for followers a lot of people make a considerable amount of charges daily from just influencing media becoming a successful influencer on media involves a lot of determination and hard work plus patience and the ability to lead several people A perfect example of a media influencer who attained great success as an influencer and maker of influencers Igor Montemor was born in Brazil but had to move to Florida with his family when he was two years old because of his father’s job he developed an interest in the world of influencers he had built a strong network of people from which he carved out an influencer marketing company He was able to achieve this by training himself extensively on the various aspects of media and studying them carefully also helped other people become influencers Media has evolved so much in recent years and so many profitable activities can be carried out on it people only posted updates and chatted with one another on media with some influencers making very much for just a single post Igor Montemor has been working with major influencers since 2011 Igor firmly believes that with time media will make everybody self dependent because of how fast it is evolving and creating opportunities for people He owns an agency called Connections Collective With Igor’s exceptional knowledge of marketing he is helping many people become media influencers with an ability to earn large sums of charges today Novo Nordisk (NVO, Financial) has announced a substantial investment of $10.9 billion equivalent to approximately 60 billion Danish kroner to expand its production facility in Monte Mor This expansion aims to increase the production capacity of its core GLP-1 diabetes medication The project is expected to be completed by 2028 and will create over 500 high-skilled jobs This strategic move comes as Latin America faces a diabetes prevalence rate of 10% making it one of the regions with the highest incidence globally and the local approval process for Wegovy is in its final stages A teenage attacker wearing an all-black SS-style Nazi uniform complete with a swastika armband was arrested after hurling homemade molotov cocktails filled with nails at a packed school in Brazil Two of the bombs - filled with petrol, nails, and ball bearings - exploded at the attacker's former school in the small city of Monte Mor about 75 miles northwest of Sao Paulo yesterday morning. After the 17-year-old bomber's attack, hundreds of terrified students from Prof. Antonio Sproesser State School were evacuated from the building, local media reported. Police arrested the teen - who was was carrying an axe and also had a replica assault rifle in his car - after responding minutes after reports came in. The jackboot-wearing suspect had left two undetonated bombs behind at the scene. Police also confiscated a notebook with Nazi insignia and a letter detailing his desire to attack the school, local media reported. Chilling CCTV footage of the attack shows the suspect - not named by police - lobbing a bomb into the school grounds from the street. A second clip shows him striding down the road with a black axe in his hand. Police also released footage of thick smoke filling the school corridors as pupils are evacuated. Inspector Denival Santana of the Municipal Civil Guard said: 'There was some uproar, the children were scared, a thunderous noise, but everything was calmed down with the arrival of firefighters and, later, support from the Military Police.' The inspector added that when the teenager was arrested, 'he didn't show any reaction' and 'he didn't give us any information, anything that could help'. A city government spokesperson said: 'There were no injuries and the individual was captured and taken to the police station.' Major terror attack 'was just HOURS away' before it was foiled by the special forces and police:... Victim of acid attack 'plotted by his ex-partner who teamed up with a gang' dies in hospital six... We are trapped in unsellable newbuild homes after a £52m dual carriageway was built on our... Pub is forced to pay family £75,000 after wrongly accusing them of 'dine and dash' over £150... Horror as $4.5M influencer-laden yacht SINKS off Miami... after glam women made a rookie maritime... How Meghan's biggest cheerleader brokered Harry's disastrous BBC interview - three months after... Woman dead and three others including a child injured after car ploughed into pedestrians: Man, 49,... 'It's a rather giant f*** you.' Royal insider's furious reaction to Meghan's Instagram salvo as... Woman who was missing for more than 60 years is found 'alive and well' decades after vanishing... How can I see the Red Arrows' iconic flypast? Map reveals when and where planes will be visible over... American tourist suffers horrific fate while attempting to capture selfie at Rome's Colosseum King, Queen, William and Kate honour selfless devotion of Britain's wartime heroes as they lead... The towns being ruined by day-tripper invasions. Selfie-loving tourists cause traffic hell and the... Hamas hostage, 23, 'raped by personal trainer influencer in her own home after being released' How 'SAS swooped on Iran-backed terror cell': Special Forces troops joined police on UK streets to... Husband of British mother, 65, who was knifed to death in French village says her affair is a... Read today's Portuguese stories delivered to your email. Montemor-o-Velho is in the district of Coimbra and has more than 26,000 inhabitants. It is 25 kilometres away from Coimbra and you can drive from the city either along the EN111, or A14. After arriving in the city, it was time to eat. The typical dish here is lamprey rice, which I did not experience, as lamprey, which is a type of eel like fish, is not my favourite dish, instead, I had beef in a lovely restaurant called A Grelha. The meal was very cheap, which surprised me because there was a lot of food on my plate, but very tasty food. The rain stopped and it was time to move. Castles are usually placed in high places, and we were all mentally prepared for the climb. But Montemor is prepared for this, and we discovered that there are escalators available to reach the castle. Montemor-o-Velho has much more to see in the surrounding parishes, however, the weather was not helping our trip and after spending more than an hour in the castle, because it takes more than an hour to visit it, we decided to drive back home and take in the great landscapes of Montemor-o-Velho. Deeply in love with music and with a guilty pleasure in criminal cases, Bruno G. Santos decided to study Journalism and Communication, hoping to combine both passions into writing. The journalist is also a passionate traveller who likes to write about other cultures and discover the various hidden gems from Portugal and the world. Press card: 8463. We appreciate that not everyone can afford to pay for our services but if you are able to, we ask you to support The Portugal News by making a contribution – no matter how small. You can change how much you give or cancel your contributions at any time. Please include maps in your articles. Yes, I can look out up in Google, but so can you and Dave all your readers the trouble. Send us your comments or opinion on this article. Reaching over 400,000 people a week with news about Portugal, written in English, Dutch, German, French, Swedish, Spanish, Italian, Russian, Romanian, Turkish and Chinese. Volume 8 - 2018 | https://doi.org/10.3389/fonc.2018.00032 The genetic events associated with transformation of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML) particularly in the subgroup of essential thrombocythemia (ET) patients Deep studies using high-throughput methods might lead to a better understanding of genetic landscape of ET patients who transformed to sAML We performed array-based comparative genomic hybridization (aCGH) and whole exome sequencing (WES) to analyze paired samples from ET and sAML phases We investigated five patients with previous history of MPN which four had initial diagnosis of ET (one case harboring JAK2 p.Val617Phe and the remaining three CALR type II p.Lys385fs*47) and one was diagnosed with MPN/myelodysplastic syndrome with thrombocytosis (SF3B1 p.Lys700Glu) All were homogeneously treated with hydroxyurea but subsequently transformed to sAML (mean time of 6 years/median of 4 years to transformation) Two of them have chromosomal abnormalities and both acquire 2p gain and 5q deletion at sAML stage The molecular mechanisms associated with leukemic progression in MPN patients are not clear Our WES data showed TP53 alterations recurrently observed as mutations (missense and frameshift) and monoallelic loss aCGH showed novel chromosome abnormalities (+2p and del5q) potentially associated with disease progression The results reported here add valuable information to the still fragmented molecular basis of ET to sAML evolution Further studies are necessary to identify minimal deleted/amplified region and genes relevant to sAML transformation Genetic changes and clonal evolution associated with ET to sAML progression remain incompletely understood in nearly 70% of patients Genome wide analysis is an useful tool to understand the molecular events underlying sAML transformation in those cases we describe five MPN patients diagnosed with thrombocytosis characterized by high platelet counts (from 623k × 109/L to 2,395k × 109/L) and enlarged megakaryocytes with hyperlobulated nuclei at bone marrow biopsy Physical exam and imaging analysis showed no splenomegalia during follow-up All patients were homogeneously treated with hydroxyurea and evolved to sAML Peripheral blood (PB) molecular screening showed three patients with CALR type II MPN and sAML samples from all five patients were analyzed by array-based comparative genomic hybridization (aCGH) Three of these patients showed molecular alterations by aCGH and were further investigated by whole exome sequencing (WES) This study was carried out in accordance with the recommendations of the “Institutional Ethics Committee (Brazilian National Institute of Cancer)” with written informed consent in accordance with the Declaration of Helsinki The clinical data provided in the current case report contain no personal health information Written informed consent was obtained from some of the participant close relatives for the publication of this case report Other participants have from 4 to 8 years since decease and clinical staff has lost follow-up with patient’s relatives making it impossible to get an informed consent for publication Longitudinal analysis of uniformly treated MPN cases Five cases were analyzed by aCGH and WES before and after therapy The horizontal axis represents the timeline (in years) of sample collection Each case is presented in the right legend Squares are showing samples analyzed only by aCGH and circles by the two methodologies applied array-based comparative genomic hybridization; MPN Clinical and laboratorial features of patients who progressed to sAML Peripheral blood samples were collected into EDTA and processed within 24 h of collection in each case DNA extraction was performed from granulocytes after submitting the blood sample to Ficoll-Hypaque® gradient The red cells were removed by hypotonic lysis solution Cell pellets were resuspended in DNAzol® (Invitrogen) and DNA was extracted following the manufacturer’s protocol Samples cleanup was done using puregene kit (Qiagen) or phenol:chloroform:isoamyl alcohol (25:24:1) protocol Clustering analysis was run using clValid package (21) from R software,7 using all somatic mutations (intronic and exonic) that showed more than 50× coverage in the tumor samples we combine data from nine clustering models (hierarchical clustering SOTA) and elected as the number of clusters presented in each patient the result recurrently found in most of nine models analyzed Other algorithms were also used: kohonen and mclust for Expectation-Maximization algorithm Internal validation was analyzed by connectivity We also used a fpc package from R software and run a prediction strength and nselectboot function for selection of the number of clusters via bootstrap and computes the prediction strength of a clustering of a data set into different numbers of components Enrichment analysis on gene sets of functional gene classes or ontology terms was performed using the analysis tool provided by Database for Annotation, Visualization and Integrated Discovery 8 (22, 23) maintained by National Institute of Allergy and Infectious Diseases (NIH) using Protein Information Resource or GO Consortium databases to execute enrichment examination We analyzed genes contained in each chromosome abnormality region (gain or loss) or genes set from each patient containing somatic mutations [by point or insertions–deletions (INDELS)] detected by WES Hematological data were analyzed using two-sided Wilcoxon signed-rank test with p = 0.05 using Prism 6 (Graphpad Clinical and hematological data are summarized in Table 1 and median follow–up time for those five patients included were 1,527 days (range 978–4,171 days) from diagnosis until transformation and 56 days (range and thrombosis were the main clinical presentations observed during follow-up All patients were screened for mutations previously described to be more frequently found upon transformation such IDH1/IDH2 (exon 4) and TET2 (exon 3) but were absent at MPN and sAML samples Other clinical relevant features from each patient are described as follows: Case 1 (UPN834): A patient diagnosed with ET CALR type II positive (p.Lys385fs*47) with bone marrow biopsy at diagnosis showing proliferation of all lineages with increased number of mature megakaryocytes and no adverse events or thrombotic events were reported during follow-up which showed 44% blasts and presence of megakaryoblasts the patient was still JAK2 p.Val617Phe negative CALR type II positive and aCGH analysis in the sAML sample showed no chromosome abnormalities Case 2 (UPN847): A patient was diagnosed with ET showed CALR type II mutation (p.Lys385fs*47) with bone marrow biopsy at diagnosis showing megakaryocyte proliferation with hyperplasia and absence of fibrosis A new bone marrow biopsy was performed 12 years after diagnosis and revealed atypic cells and presence of micromegakaryocytes No chromosome abnormalities were observed in the granulocyte fraction at sAML blood sample by aCGH WES analysis of these same samples showed 171 single-nucleotide variants/INDELS (SNV/INDELS) with variant allele frequencies (VAFs) ratio higher than 1.5 between the two samples analyzed (Table S1 in Supplementary Material) WES analysis of two paired samples revealed 211 SNV/INDELS with chronic/sAML VAF ratio at least more than 1.5 (Table S1 in Supplementary Material) WES screening identified 206 differentials SNV/INDELS with VAF ratio chronic/sAML at least more than 1.5 (Table S1 in Supplementary Material) Comparative list of chromosome abnormalities found since MPN phase showing differences in chromosome gain and losses in the two samples analyzed per patient we observed five cases of sAML transformation reported herein Comprehensive genomic characterization of paired samples by aCGH identified two common genetic abnormalities—gain of 2p and deletion of 5q—not identified in initial ET but present in the sAML phase, suggesting that they were acquired during disease progression (Table 2; Figures 2A,B) The common deleted region in chromosome five covers cytobands q23.3–q35.3 and the 2p minimal gain region comprised cytobands p13.3–p25.3 (A,B) Size and type of the abnormalities found at chronic phase (A) and sAML (B) samples from three patients analyzed by aCGH Abnormalities found at chronic phase remained until sAML Gains are represented above and losses below X-axis; note that there are more abnormalities found at sAML and they are larger compared to chronic phase array-based comparative genomic hybridization; chr The three patients with chromosomal abnormalities were subsequently analyzed by WES. Mutations in paralogous genes already associated with MPN phenotype such as CALR3, ASXL2, and TET3 were found augmented at sAML sample from ET patient positive for CALR (p.Lys385fs*47) (Figure 3C; Table S1 in Supplementary Material) A novel JAK2 mutation p.Arg1063Cys was found at MPN/MDS patient who carries a SF3B1 p.Lys700Glu since the first sample analyzed (A–C) Genomic landscape of thrombocythosis (ET and MPN/MDS) that progressed to sAML VAF of candidate driver mutations or paralogous genes already associated with MPN phenotype in each patient analyzed are depicted in upper panels Model of clonal evolution of MPN to sAML showing average VAF of each subclone in the stages analyzed Clonal evolution complexity showing VAF of mutations found in each clone per patient in MPN (abcissa) and sAML (ordinate) stages is depicted in the lower panels VAF plots were generated by mclust after running fpc and nselectboot functions The analysis of clonal architecture showed a founding dominant clone and the subsequent rise of a minor genetic subclone growing overtime in all the three cases analyzed (Figures 3A–C) No recurrent gene mutations were found among patients and samples analyzed besides the TP53 and JAK2 alterations aforementioned (Table S1 in Supplementary Material) Genomic studies evaluating serial samples of MPNs are few (24, 25), especially in the subgroup of ET (26, 27) Our work is one of the few reports associating aCGH and WES data in sequential paired samples from ET diagnosis to sAML progression Other possibility is that chromosome alterations are present but at low frequency thus undetectable by the methods used in our approach −5q MDS represents a well-known subgroup with cellular and molecular mechanisms well understood Comparative studies showing previous reports in +2p and del5q in myeloproliferative and myelodysplasia neoplasms Genomic abnormalities targeting cytokines and cytokine receptors clusters are described in several types of tumors, such as loss of chromosome 4 and the subsequent decreased IL15 expression in colorectal cancer (37) The potential role of cytokine cluster deletions in MPNs depends on the description of such molecular phenomena in larger cohorts and on mechanistic studies on how these deletions can impact the leukemic niche and/or the sAML transformation process We identified a novel JAK2 mutation at kinase domain that is predicted to result in STAT5 activation, as suggested by a previous study that showed a mutation in the same residue, JAK2 p.Arg1063His, associated with STAT5 phosphorylation and increase of CFU-E formation, in addition to in silico modeling, which predicted a facilitation of the active conformation of JH1 (38) Clonal analysis showed the molecular heterogeneity among ET patients, as no recurrent gene mutation was found. Even comparing our data with other WES findings, we could not find any recurrent gene mutation, corroborating Engle et al. (25) findings describing that most mutations found in a patient with secondary myelofibrosis who progressed to sAML are passenger mutations with a clonal architecture similar to the ones described in our patients Secondary Acute Myeloid Leukemia progression is a rare event studies with paired sample analysis are scarce adds valuable information to understand the molecular basis of sAML transformation Our data showed chromosome abnormalities potentially associated with disease progression not previously described and those abnormalities (+2p and del5q) have common regions that should be further screened This study was carried out in accordance with the recommendations of the Institutional Ethics Committee (Brazilian National Institute of Cancer) with written informed consent in accordance with the Declaration of Helsinki The clinical data provided in the current case report contains no personal health information or personal feature to protect participants’ rights and EB analyzed molecular data and wrote the manuscript JA-S and DC performed and developed molecular assays and contributed to the interpretation of data All authors made a substantial contribution and approved the final version of the manuscript All the authors are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The reviewer PB and the handling editor declared their shared affiliation The authors would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Mayo Clinic for supporting this study Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) JPAS was supported by a scholarship of the Brazilian Ministry of Health and CNPq (Sandwich PhD-Science without borders) The Supplementary Material for this article can be found online at http://www.frontiersin.org/articles/10.3389/fonc.2018.00032/full#supplementary-material AML transformation in 56 patients with Ph− MPD in two well defined populations CrossRef Full Text | Google Scholar Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms Br J Haematol (2017) 179(4):530–42 CrossRef Full Text | Google Scholar Genomic classification and prognosis in acute myeloid leukemia Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms CrossRef Full Text | Google Scholar The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders JAK2V617F mutation in patients with splanchnic vein thrombosis Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosis Blood Cells Mol Dis (2016) 60:74–7 and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor 14. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Ilana Renault Zalcberg, emFsY2JlcmdAaW5jYS5nb3YuYnI= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. The Galeria Estação art gallery starts the year with an exhibition of the artist Mirian Inês da Silva (1939-1996), who hails from the state of Goiás. Under the curatorship of teacher Miguel Chaia, the exhibition takes up the second and third floors of the art gallery and has a collection of over 70 works, including painting and wood cuttings by this artist who became well known through her engravings showing significant inventiveness and expression. © 2025, thestatesman.com | All rights reserved Volume 8 - 2021 | https://doi.org/10.3389/fmats.2021.804906 This article is part of the Research TopicCorrosion and Protection of Magnesium AlloysView all 11 articles A correction has been applied to this article in: Corrigendum: Rare Earth Based Magnesium Alloys—A Review on WE Series Magnesium and magnesium alloys have attracted growing attention over the last decades as lightweight materials for a wide range of applications WE series magnesium alloys have experienced growing interest over the last years due to their favourable mechanical properties at room and elevated temperatures it has been reported that these rare earth-containing alloys possess superior corrosion resistance compared to other commonly used magnesium alloys This review aims at providing a concise overview of the research efforts made during recent years regarding the properties of WE series magnesium alloys (e.g. how these properties can be enhanced by controlling the microstructure of these materials and the role of specific alloying elements that are used for the WE series The widespread use of these materials has been limited mainly due to their susceptibility to corrosion strong emphasis has been given to recent work studying the corrosion behaviour of the WE series alloys and to protective strategies that can be employed to mitigate their degradation TABLE 1. Lettering code for main alloying elements in magnesium alloys. Data based on (Moosbrugger, 2017) During magnesium corrosion, formation of a magnesium hydroxide film on the surface of the metal occurs, accompanied by local alkalization (Makar and Kruger, 1993). The global corrosion reaction of magnesium (Eq. 1) can be divided into an anodic and a cathodic reaction (Feliu and Llorente, 2015): still a controversial and intensively discussed topic WE series magnesium alloys possess yttrium and rare earths as major alloying elements (see Corrosion of Magnesium and Magnesium Alloys ) minor alloying elements for this series of alloys include neodymium Development of Mg-Y alloys has been an ongoing process for several decades (Polmear, 1994). Continuous demands for high performance lightweight alloys led to the development of the WE series magnesium alloys (Lyon et al., 1991) Several different alloys are part of this category these alloys have rarely been discussed in literature and no significant studies can be found regarding these alloys This is mainly related to the fact that WE43 and WE54 possess the most adequate cost-benefit relation of the alloys included in the WE series the increasing interest in WE43 and WE54 as lightweight solutions for different industry sectors has brought on and increasing number of publications regarding these two alloys in detriment of other alloys included in the WE series the present review focuses primarily on WE43 and WE54 with continued research regarding WE series Mg alloys new and improved alloy formulations are likely to be developed and implemented in industry Comparison of mechanical properties at room temperature of as-fabricated WE43 Comparison of different physical properties of as-fabricated WE43 extending even further the advantages of their use for a wide range of applications The age hardening characteristics of WE series magnesium alloys are closely related to the precipitates that are formed during these treatments (see Heat Treatments) Comparing the age hardening behaviour of WE alloys with other magnesium alloys, WE43 and WE54 usually present enhanced age hardening response. AZ31, for example, exhibits a weak strengthening effect, displaying a nearly constant hardness over ageing time (Xu et al., 2018). Furthermore, artificial ageing processes have also a more positive effect on the mechanical properties of WE series magnesium alloys than on EV31 (Kiełbus et al., 2018) FIGURE 1. Microstructure of as-cast WE43. (A) Optical micrograph evidencing the α-Mg matrix of WE43; (B) Scanning Electron Microscopy image of WE43. Images reproduced from (Kang et al., 2020) under the terms of the Creative Commons CC-BY 4.0 License In order to further enhance alloy performance WE series magnesium alloys are usually subjected to different heat treatments (see Heat Treatments) Heat treatment has an important influence on alloy microstructure and direct comparison of mechanical properties of WE series alloys obtained by different processing methodologies and/or subjected to different heat and ageing treatments is not feasible since widely different processing parameters are used throughout literature in addition to the varying original conditions of the studied alloys The rare earth content specified for each magnesium alloy from the WE series is a mixture of different rare earth elements that vary from alloy to alloy. Most commonly, the rare earth elements included in the alloys are Nd and other heavier REEs such as Gd (Pan et al., 2016) Gd content in commercial WE series magnesium alloys is usually kept low In addition to the benefits discussed above, yttrium, gadolinium, and neodymium increase the ignition temperature and flammability resistance of magnesium alloys (Tan et al., 2019). This effect has been attributed to the ability of these elements to form a rare earth-containing oxide layer on the magnesium alloy surface, preventing the access of oxygen, moisture and aggressive species to the alloy (Tan et al., 2019) The corrosion mechanism of WE series magnesium alloys has been extensively studied over the years the corrosion resistance of metal alloys is tested during immersion of the alloy under study in an appropriate electrolyte these studies have been carried out in a wide range of different electrolytes The most commonly used media for the study of aqueous corrosion of WE magnesium alloys are NaCl and electrolytes that simulate physiological conditions These seemingly contradictory results can be related to the use of different combinations of parameters such as electrolyte type processing methodology of the studied alloys and heat treatments to which the alloys were subjected prior to corrosion testing As is the case for the previously stated mechanical properties of WE series magnesium alloys the microstructure of these materials has a major influence in their corrosion behaviour FIGURE 2. Possible mechanism of corrosion for WE series magnesium alloys (A), involving the formation of a Mg(OH)2 layer on the surface of the alloy (B), with localized microgalvanic corrosion at preferential sites (C). Figure reproduced from (Kharitonov et al., 2021) under the terms of the Creative Commons CC-BY 4.0 License The overall corrosion behaviour of WE series magnesium alloys seems to be governed by two major factors: on the one hand, the microgalvanic coupling effect encountered between the intermetallic phases and the magnesium matrix has a detrimental effect on the corrosion performance of these materials; on the other hand, the incorporation of rare earth elements in the surface film during alloy corrosion can be beneficial (Leleu et al., 2019) Even though WE series magnesium alloys may possess a somewhat enhanced corrosion resistance when compared to other magnesium alloys the anticorrosive performance of these materials has to be further improved for most applications Several different protection strategies against corrosion of WE magnesium alloys are reported in Corrosion Protection Strategies The development of protective coatings for magnesium alloys for their use in the automotive and aerospace industries is aimed at the maximum possible long-term protection of the alloy coatings developed for biological applications are often aimed at slowing down substrate dissolution to allow for the use of magnesium alloys as bioresorbable temporary implants Given the newly-gained interest in WE series magnesium alloys for industrial applications the vast majority of literature concerning protective strategies for WE series magnesium alloys to date is based on protective solutions which have proven efficiency for other magnesium alloy series Coatings applied by electrolytic processes (e.g. PEO) seem to display minimal dependency on the specific composition of the alloy and/or on the type and distribution of its secondary phases the microstructure and composition of each alloy is expected to play a more major role in the application of organic and hybrid organic-inorganic coatings mainly due to different interactions between the coating and the alloy surface corrosion inhibitors may display protective mechanisms which are dependent on the interaction with specific alloying elements and/or secondary phases of the Mg alloy under study literature on passive corrosion protection strategies and active self-healing coatings for WE series magnesium alloys is too scarce to evaluate these specific challenges effectively and objectively the protective strategies cited in this review give an overview of protective mechanisms with proven efficiency for WE43 and WE54 alloys Since the coatings formed via anodization or PEO are usually porous a top-layer can be applied to seal the pores and impart additional protection FIGURE 3. Evolution of low frequency impedance modulus (0.01 Hz) of WE43 coated with a hybrid epoxy-silane coating (reference coating), and with a hybrid epoxy-silane coating containing 325 ppm Ce(DEHP)3, during immersion in 0.5 M NaCl. Image reproduced from (Calado et al., 2021) with permission FIGURE 4. Mechanism of corrosion protection conferred by Ce(DEHP)3 to WE43 magnesium alloy. Figure reproduced from (Calado et al., 2021) with permission The development of protective coatings for WE series magnesium alloys is still a growing research topic which is in no way as explored as the development of protective solutions for other magnesium alloys The superior properties of WE series magnesium alloys has led to an increasing usage of these types of alloys in different industries in addition to a growing research interest in several fields The good high temperature behaviour of WE magnesium alloys allied to the low density of these materials has been of particular interest for the automotive and aerospace industries In the automotive sector, WE alloys are widely used in high-performance cars as engine block components, e.g., pistons and cylinders (Kierzek and Adamiec, 2011; Malayoğlu and Tekin, 2015). Furthermore, given their superior creep resistance and high temperature stability, in contrast to other magnesium alloys, WE series alloys are expected to be suitable for powertrain applications (Blawert et al., 2004) WE43 became particularly interesting for application in cabin seat frames magnesium and magnesium alloys are attractive lightweight materials for many different industries such as the automotive and aerospace sectors These materials are also envisaged as appropriate for biodegradable implants the good high temperature properties and general mechanical behaviour of WE alloys make this class of magnesium-based materials especially interesting for a wide range of applications these alloys have some drawbacks associated to their use for certain applications such as a high cost of rare earth elements and general susceptibility to corrosion research regarding WE series magnesium alloys will continue to focus on further enhancement of the properties of these materials and mitigation (or even elimination) of some shortcomings of these alloys Fine-tuning alloy composition and microstructure through alloying and/or through the use of new processing methodologies will play an important role for further property improvement To take full advantage of the favourable properties of WE series magnesium alloys the corrosion susceptibility of these materials needs to be addressed Advances in the development of efficient corrosion protection strategies tailored for these types of alloys are currently being made development and application of multifunctional and self-healing coatings that are able to provide long-term protection and that are able to prevent corrosion propagation if the coating is damaged during its lifetime will play a major role in further improving the performance of WE magnesium alloys for an even wider range of applications in addition to a growing interest in these materials for several industries mainly the automotive and aerospace sectors emergence of an increasing number of new applications is expected to lead to a continuous increase in the global demand for WE series magnesium alloys over the next years WE series alloys possess superior room temperature mechanical properties when compared to other magnesium alloys these alloys have the ability to retain their properties at high temperatures which constitutes a clear advantage in comparison to other classes of magnesium alloys Several different thermal and solution treatments are available for WE series magnesium alloys Properties such as strength and ductility can be precisely controlled by the use of different combinations and sequences of ageing temperature and duration continued research efforts have been carried out to obtain a fundamental understanding of the precipitation sequence that occurs during ageing treatments and of the possible changes in alloy microstructure the role of specific alloying elements and their content in common WE series magnesium alloys has been heavily studied over the years Direct modification of the content of specific alloying elements can also be a way of controlling alloy properties New processing methodologies have been emerging as a means to improve the properties of magnesium alloys in general most experimental processing techniques are based on severe plastic deformation of the alloy These techniques have been used to obtain ultrafine grain microstructure in the processed material Significant grain refinement has been obtained for WE alloys using ECAP and HPT which in turn leads to improvement in hardness and overall mechanical properties of these alloys The scalability of these processes to industrial scale is currently under study WE series magnesium alloys are susceptible to corrosion efficient protection strategies are needed to mitigate the degradation of these materials Anodization and PEO have been the most used techniques for the protection of WE alloys but a wide range of coating types has been 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited *Correspondence: Lénia M. Calado, bGVuaWFjYWxhZG9AdGVjbmljby51bGlzYm9hLnB0 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Montemor-o-Velho already hosted the FISU World University Championship Canoe Sports back in 2016 and is ready to once again welcome the best student-athletes on its waters from 21-24 August This is the second time that Portugal’s National University Sport Federation (NUSF) of Portugal, FADU organises the FISU World University Championship Canoe Sports But this event is also the 16th FISU World Championship hosted by this very active NUSF the municipality of Montemor-o-Velho belongs to the district of Coimbra a privileged region for tourist destinations with great cultural the High Performance Sports Centre in Montemor-o-Velho is designed to accommodate canoeing open water swimming and triathlon and is part of the Portuguese Network of High Performance Sports Centres Kayak 2 and Kayak 4) as well as four distances (200m 1000m and 5000m).Canoe Marathon: Two groups (men and women) 16 km for K1 women; 16 km for C1 men and 12 km for C1 women Each country is allowed to register two boats per gender and two boats for each category More than 200 student-athletes from 24 countries and three continents have registered for the event and are eager to “paddle with passion and compete like a champion” to perfectly illustrate the event’s motto 20 August (9h30-20h):Canoe Sprint (official training session and GTM)Opening Ceremony21 August (9h30-19h):Canoe Sprint (200m/5000m) – Heats Finals 22 August (9h30-19h):Canoe Sprint (1000m) – Heats Finals23 August (9h30-16h30):Canoe Sprint (500m) – Heats Semi-Finals24 August (9h30-18h30): Canoe Sprint (500m) – FinalsMarathonClosing Ceremony You can follow all competitions live on FISU.tv and find all the information you need, results and pictures in the event’s official website Good luck to all the student-athletes who are competing in Montemor-o-Velho © International University Sports Federation Metrics details The sex profile estimation of pre-historic communities is often complicated by the commingled and scattered nature of skeletal assemblages Demographic profiles are usually lacking and provide very truncated representations of these populations but proteomic analysis of sex-specific amelogenin peptides in tooth enamel brings new promise to these studies The main objective was to obtain the sex profile of the human assemblage recovered from the Neolithic cave-necropolis of Escoural (Montemor-o-Novo southern Portugal) through liquid chromatography-mass spectrometry The secondary objective was to analyse sex-specific linear enamel hypoplasias (LEH) and to test the reliability of canine odontometric sex estimation Sex estimation through peptide analysis was carried out in 36 left permanent canines which were macroscopically examined for the presence of LEH The canine buccolingual diameter was used for odontometric sex estimation probably due to cultural factors since the natural sex ratio of the human population falls between 0.95:1 and 1.02:1 (M:F) but with no significant sexual differences (p = 0.554) The mean LEH age of onset occurred at 3 years of age with no significant differences between the sexes (p = 0.116) and was possibly related to the weaning process Odontometric sex estimation revealed a correct classification of 80% with a high number of males mistakenly attributed to females This study is one of the largest samples subjected to peptide analysis and thus demonstrates its usefulness on the research of commingled and scattered skeletal assemblages for which the sex profile is discussed in this paper it is often not sufficiently preserved in collective tombs with commingled and scattered remains to allow for the widespan estimation of sex The main objective of this paper was to obtain the most complete as possible sex profile of the collection of human remains from the Neolithic cave-necropolis of Escoural Secondary objectives were to assess potential sex differences regarding LEH-monitored physiological stress events and to test the reliability of canine odontometric sex estimation by comparing it with the sex classifications obtained through the peptides analysis this paper provides a comprehensive portrait of the sex profile of the Escoural Cave-necropolis which is inclusive of both adult and non-adult individuals a feat never before achieved for Neolithic human populations inhabiting this Portuguese inner Alentejo region Location of the Escoural Cave in the Alentejo region southern Portugal (A,B) and photo of its main room I (C) (© M plan of the intermediate floor used for funerary purposes The colored circle shows the area of greatest concentration of human remains Lacroix under the responsibility of Ana Cristina Araújo) Generally, the human remains were commingled on the surface layers and were clustered in “groups” (Fig. 3), attaining a MNI of 109 (42 immatures and 67 matures). Apparently, bones from each individual were not scattered onto multiple clusters, since bone pairs were always found intra-group. Group 7 from Room 1 photographed in the 1960’s PT/MNA/APMH/2/11/32/18-49 ©DGPC/MNA—Farinha dos Santos/Museu Nacional de Arqueologia/National Museum of Archaeology Escoural Cave, Group 1 from Room 1 (the white circle shows an individual in anatomical connection) housed in National Museum of Archaeology in Lisbon, Portugal (© Raquel Granja). Escoural Cave, cranium on a shelf in Gallery 7 photographed in the 1960’s. PT/MNA/APMH/2/11/32/21-49 ©DGPC/MNA—Farinha dos Santos/Museu Nacional de Arqueologia/National Museum of Archaeology, Lisbon, Portugal. cranium in a niche in Room 1 photographed in 1960’s PT/MNA/APMH/2/11/32/30-49 ©DGPC/MNA—Farinha dos Santos/Museu Nacional de Arqueologia/National Museum of Archaeology but there is no graphic or photographic documentation of this putative funerary practice in the archives of the National Museum of Archaeology Human remains were found also outside the cave next to the south-western natural entrance Radiocarbon results from bone samples retrieved in this outer area do not differ from those obtained inside the cave pointing to its funerary use during the Late Neolithic (~ 3600 to ~ 3000 cal BC) some skeletal remains display on their surfaces the same carbonate concretions that characterize the material from inside the cave suggesting that their primary origin was also most likely this same both samples from inside and outside the cave were brought together and studied as one for the purpose of this study Three of these canines were not completely formed (root mineralization was ¼ complete in two teeth while initial root formation with diverse edges was presented by another tooth) eight had a broken root and 25 were mature or in mature mandibles The wear was described as 10% if the tooth presented a grade-2 wear as 5% if it presented a grade-1 wear and 0 if no wear was present (c) Maximum ion intensities of peptide SM(ox)IRPPY (AMELY; [M+2H]2+ 440.2233 m/z) vs peptide SIRPPYPSY (AMELX; [M+2H]2+ 540.2796 m/z) this latter reported as log10; males (as estimated through proteomics) are orange dots while (possibly) females are dark-green dots; the red dashed line is the male with the lowest 540.2796 m/z signal the overall sex ratio of 0.52:1 in favour of females Bearing in mind that the sample outside the cave was relatively small a higher number of males was observed outside the cave compared to females A more complete sex profile of the assemblage was obtained by adding one other female individual whose sex estimation was achieved through the hip bone morphology of the individual in anatomical connection a more female-prone sex ratio of 0.5:1 (M:F) was obtained overall 75%) with no significant sexual differences found between both sexes (χ2 = 350; p = 0.554) Most individuals displaying only one LEH defect (females: 9/15 Two defects were observed in 27% of females (4/15) and 17% of males (2/12) while three defects were observed in 13% of females (2/15) and 8% of males (1/12) The mean LEH age of onset was 3.5 years in 12 females and 3.9 years in 7 males the difference being non-significant (p = 0.116) The youngest age of onset was 2.6 years in females and 3.2 years in males while the oldest age of onset was 4.4 years and 4.6 years the highest number of LEH cases occurred during the third year of life it is possible to conclude that there are no significant differences between sexes (p = 0.554) both sexes were equally affected by physiological stress events The intra- and inter observer variations of the buccolingual diameter provided %TEM below 2%, demonstrating the good replicability and repeatability of this standard measurement (see Supplementary Table S2 for details) The high coefficient of reliability (≥ 93%) indicated that only a small portion of the measurement variance in the sample was the result of measurement error Assuming that peptide-based sex estimations are correct the reliability of odontometric sex estimation was calculated The buccolingual diameter allowed for 80% correct sex classification of the overall sample the agreement between the peptide and the odontometric sex estimations was moderate (0.53; p = 0.001) and 91.3% of females (21/23) and only 58.3% of males (7/12) were allocated to the correct sex It should be noted that all but one of the male teeth presented dental wear incompatible with a non-adult age the well-marked imbalance in the sexual profile of the dead deposited in the Escoural Cave seems to be more related to anthropogenic choices of a socio-cultural nature and may reflect: (i) the contemporary demographic pattern also unbalanced or (ii) choices dictated by cultural perceptions regarding the dead and death sex-ratio was exclusively obtained through odontometric evaluation; so Other Portuguese cave-necropolises offer little data in terms of sex-ratio the number of individuals on which sex estimation was achieved is much lower than the minimum number of individuals (MNI) recorded in each of these cave-contexts This problem becomes even more complex if the discrepancy in the assessment methods used for sex estimation (and not always fully available) is added to the debate the set of cave-necropolises recorded for Portuguese archaeology does not meet the conditions to support the hypothetical sex-ratio imbalance suggested by the data from the Escoural Cave based on several radiocarbon results (more than 30) points to their use mainly during the Late Neolithic (~ 3600 to ~ 3000 cal BC) although three additional values deviate from this chrono-cultural framework (this subject deserves a much deeper discussion Bom Santo remains the best reference for comparisons although it is somewhat older than Escoural these studies suffer from the issues mentioned above and/or are from later chronologies As for hypothetical scenarios explaining the unbalanced sex profile in the Escoural Cave no archaeological evidence is particularly instructive We were unable to build a comprehensive age and health profile for this assemblage so it was not possible to assess if the male population was particularly old or unhealthy compared to females this could be suggestive of a scenario in which younger or more active men were dying somewhere distant from the cave (and the settlement) This would possibly be the case in situations involving warfare or transhumance assuming that those activities were mainly performed by males no strontium isotope analyses were performed to check for possible migration patterns which could have contributed to the sex profile here observed the Escoural Cave was not restricted to one of the sexes since both female and male individuals were found in it the possibility of a sex restriction rule having occurred at some point of its utilization as a necropolis cannot be entirely discarded even if implemented during a shorter period could result in the unbalanced sex profile obtained by our forcibly synchronic analysis If a sex restriction was in place at some point in time this would mean that specific funerary ordinances were applied to segments of the community the dolmens in the region did not preserve organic material that can be used for comparative purposes The LEH frequency in the Portuguese prehistoric necropolises is below 42% in most of the sites The ones with the highest LEH frequencies (above 60%) are also the ones where fewer individuals were assessed (below 40% of the MNI) Regarding Neolithic caves (Escoural and Caldeirão) LEH was observed in more than two thirds of the individuals these frequencies appeared all to be under or equal to 30% in dolmens due to the scarcity of data is not possible thus precluding the estimation of LEH onset age Only used here as an illustration of the benefit of using sample-specific metric references that are more adjusted to the population under study the informal testing of the sample-specific cut-off point would result in a more balanced correct sex classification (females: 77%; males: 75%) the odontometric approach does not guarantee a reconstitution of the sex profile as reliable as those obtained from DNA and peptide analyses Some degree of error should be expected from sex ratios obtained through canine buccolingual diameters 20 to 25% of the sample was incorrectly sex estimated following the application of sample-specific cut-off points in the Escoural assemblage the use of intervals taking into account such magnitudes of variation appears to be recommendable This research sheds new light on the way of life of the Neolithic community that used the Escoural Cave 5000 years ago this is the largest Portuguese sample subjected to peptide sex estimation the cave played a differential role in the funerary processing of women and men of this Neolithic community which mirrors the one reported for communities from northern Iberia the LEH analysis suggested that stress physiological episodes in the infancy were probably equally frequent and transverse to both sexes The large presence of LEH can possibly be explained by a stressful weaning process which equally affected all analysed individuals at similar ages independently of their sex The new and important data gathered in this research were only possible to obtain thanks to the uniquely good preservation of the numerous human remains of this archaeological site which is culturally homogenous the large number of recovered teeth enabled the proteomic analysis of sex-specific amelogenin peptides This new methodology is ground-breaking and overcomes problematic issues related to the sex estimation of immature and mature individuals especially in contexts where remains are commingled as is often the case in prehistorical necropolises Peptide analysis allowed us to go further in terms of a more holistic assessment of funerary practices this approach can promote the active re-visitation of other emblematic Portuguese Neolithic sites and it would be interesting to extend this approach to the individuals deposited in other coeval tombs Peptide analysis appears to have an advantage over the forcibly reductive osteological examination of commingled and scattered remains as well as over the considerably more expensive aDNA analysis thus constituting an appealing resource for bioarchaeological research The generated during and/or analysed during the current study are available in the Zenodo repository (https://zenodo.org/record/8188927) A gruta-necrópole neolítica do Algar do Barrão (Monsanto Evangelista, L. 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Undertaking sex assessment of human remains within cultural heritage: Applicability of minimally-invasive methods for proteomic sex estimation from enamel peptides.https://doi.org/10.2139/ssrn.4439221 In Ortner’s Identification of Pathological Conditions in Human Skeletal Remains (ed In Biological Anthropology of the Human Skeleton (eds Katzenberg stress and evolution: Case studies in bioarchaeology and palaeoanthropology In Tooth Development in Human Evolution and Bioarchaeology (ed Work and Violence Over Two Millennia (eds Steckel et al.) 175–197 (Cambridge University Press Brief communication: The London atlas of human tooth development and eruption Dental markers of disease and malnutrition Weaning and infant mortality: Evaluating the skeletal evidence Gruta do Escoural: necrópole neolítica e arte rupestre paleolítica (Trabalhos de Arqueologia 8 Instituto Português do Património Arquitectónico e Arqueológico Datações absolutas para contextos funerários do Sul de Portugal: algumas reflexões em torno das arquiteturas e dos espólios Megalitismo funerário no Alentejo Central: os dados antropológicos das escavações de Manuel Heleno In Investigaciones histórico-médicas sobre salud y enfermedad en el pasado (eds Cerdá E.) 763–781 (Grupo Paleolab e Sociedad Española de Paleopatología Perscrutando espólios antigos: a anta de Sobreira 1 (Elvas) On mounds and mountains “Megalithic behaviours” in Bom Santo Cave In Megalithic Monuments and Cult Practices Proceedings of the Second International Simposium (eds Markov et al.) 114–123 (Neofit Rilski University Press Manifestações votivas da necrópole da Gruta do Escoural In Actas do II Congresso Nacional de Arqueologia 95–97 (Ministério da Educação Nacional Manifestações neolíticas no contexto dos testemunhos pré-históricos do Outeiro da Herdade da Sala (Escoural In Actas do XVII Congreso Nacional de Arqueologia 135–142 (Secretaría General de los Congresos Arqueológicos Nacionales Exploring prenatal and neonatal life history through dental histology in infants from the Phoenician necropolis of Motya (7th–6th century BCE) New distance-based exponential regression method and equations for estimating the chronology of linear hypoplasia (LEH) defects on the anterior dentition Cares-Henriquez, A. 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Hunter-gatherer genetic persistence at the onset of megalithism in western Iberia: New mitochondrial evidence from Mesolithic and Neolithic necropolises in central-southern Portugal. Quat. Int. https://doi.org/10.1016/j.quaint.2023.03.015 (2023) Demographic differences between funerary caves and megalithic graves of northern Spanish Late Neolithic/Early Chalcolithic The Megalithic builders: New data on old bones from the Megalitho do Facho (Figueira da Foz Insights into the funerary practices in the dolmen of Cabecinha (Figueira da Foz The forgotten bones of the dolmen of Carrascal (Agualva Silva, A. M., Sousa, A. C. & Scarre, C. A closer look at the forgotten bones of the dolmen of Pedras Grandes (Odivelas, Portugal). Examining old human remains. SPAL 30(2), 20–46. https://doi.org/10.12795/spal.2021.i30.16 (2021) Gender inequalities in Neolithic Iberia: A multi-proxy approach Sex ratio as an indicator for analyzing the population of Iberia from the 8th to the 3rd millennia BC Cardoso, F. A. Problemas de crescimento no Mesolítico português. Contribuição de alguns indicadores de stress. https://doi.org/10.13140/RG.2.1.4804.4566 (2001) Mesolithic-Neolithic continuity: evidence from chronology and human biology In Actas da I Reunião do Quaternário Ibérico (ed Grupo de trabalho português para o estudo do Quartenário & Grupo español de trabajo del Cuartenario) 113–133 (Fundação Calouste Gulbenkian The Mesolithic-Neolithic transition in Portugal: Isotopic and dental evidence of diet A calibração das datas de radiocarbono dos esqueletos humanos de Muge Radiocarbon dating of human skeletal material from two sites in Portugal Peyroteo-Stjerna, R. 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Adv. 6, eaay2169. https://doi.org/10.1126/sciadv.aay2169 (2020) Sexual dimorphism in tooth crown diameter of the cook Islanders Function and Evolution of Teeth (eds Smith Sexual variation in bucco-lingual dimensions in Turkish dentition Odontometrics: A useful method for sex determination in an archaeological skeletal population? Ruengdit, S., Riengrojpitak, S., Tiensuwan, M. & Santiwong, P. Sex Determination from Teeth Size in Thais. Preprint at https://forensic.sc.mahidol.ac.th/proceeding/52_Sittiporn.pdf (2011) Sexual dimorphism in permanent teeth of modern Greeks An assessment of sexual dimorphism and sex estimation using cervical dental measurements in a Northwest Coast archaeological sample Download references Raquel Granja has received research support from Portuguese Foundation for Science and Technology through a PhD grant (grant SFRH/BD/146991/2019) The authors thank the director and all technical staff of the National Museum of Archaeology for providing access to the collections and for allowing us to carry out the sampling programme for these investigations The authors also thank Rita Peyroteo-Stjerna for reviewing the manuscript and for her efforts in taking the MoreEscoural forward The authors thank the ‘Fondazione Cassa di Risparmio di Modena’ for funding the nLC-MS system at the Centro Interdipartimentale Grandi Strumenti of UNIMORE Filippo Genovese are deeply thanked for the assistance during LC-MS analyses Laboratory of Archaeosciences (LARC/CIBIO/InBIO) Research Centre for Anthropology and Health (CIAS) Department of Chemical and Geological Sciences Centre for Functional Ecology-Science for People & the Planet (CFE) contributed to the study conception and design data collection and analysis were performed by R.G. The first draft of the manuscript was written by R.G and all authors commented on previous versions of the manuscript All authors read and approved the final manuscript Download citation DOI: https://doi.org/10.1038/s41598-023-47037-4 a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology Maybe Try Using The Search Or Navigate To Homepage Please Login or Register to save the story Please Login or Register to delete saved story The 17th edition of the Unicamp Open Doors Program – UPA 2022 is approaching and should bring excitement to the Barão Geraldo campus and more than 30 students are expected to learn about undergraduate courses and the structure of faculties and teaching and research institutes and to participate in various activities prepared by professors Among the educational institutions registered for the UPA are schools throughout the State of São Paulo and Mato Grosso do Sul the courses that most interest students are in the areas of health and technology Pedro Felipe Souza wants to learn about the Pharmacy course and check out the musical attractions scheduled for the Teatro de Arena and Palco Saúde whether because of the structure of the campus or for the support and opportunities it offers to students Natasha Neves highlights the class's interest in learning about the courses and details of university life "We believe it will be an excellent opportunity for us to present the structure and courses offered by Unicamp to students We know the importance of attending universities of excellence for the personal and professional growth of our students" "UPA is a highly anticipated moment for our students it is very important that students have the opportunity to get to know the campus the Unicamp courses and the people who are where they intend to be in the future and their excitement reflects positively on the other students at the school" "Some colleagues already know the area they want to pursue the visit will show the possible paths and help those who have not yet decided to be a student at Unicamp in the coming years" student of the technical course in Systems Development who wants to continue in the technology field: "Nothing better than getting to know an institution that is a national reference Luiz Fernando Pereira still has doubts about which area he intends to pursue That's why I want to get to know all types of areas who also wants to get to know the open spaces on campus : “I love outdoor spaces I've seen several videos that show this." UPA 2022 activities will take place throughout the entire day of the event and can be seen on the website upa.unicamp.br under the tab “programming” and in the “Unicamp de Portas Abertas” application Visitors will be able to visit laboratories workshops and auditoriums and observe the operation of equipment and resources used in scientific research and experiments There will also be demonstrations of experiences and professional practices The units offer lectures and conversation circles on the curricular structure of undergraduate courses professional performance and topics related to different areas of knowledge exchange experiences and ask questions with teachers students and professionals who have graduated from Unicamp It will be possible to get to know the units' student entities and associations and important bodies and services for university life such as the Cesar Lattes Central Library (BCCL) and the Student Support Service (SAE) Visitors will also be able to obtain information about the Unicamp Entrance Exam from the Permanent Commission for Entrance Exams (Comvest) To facilitate visits to the entire Barão Geraldo campus UPA will have buses that will travel four routes For those who prefer to enjoy the campus trees and open spaces at Unicamp Monitors will accompany visitors and will be able to answer any questions that arise along the routes those who cannot attend the Unicamp campus will still be able to participate in the UPA The Executive Secretariat for Communication (SEC) will present a special program It will have special guests and will present to the public some of the services and differences offered by Unicamp to its students Three food courts will be available with various gastronomic options They will be installed in Praça do Ciclo Básico close to the FCM and in the reception space (Central Library pocket). Unicamp has been concerned with preventing the transmission of Covid19 on its campuses the university recommends that visitors wear masks throughout their visit and reinforces that their use will be mandatory in closed environments It also advises constant hand hygiene and not to attend if you have symptoms of the disease on the day of the event Barão Geraldo Campus (Campinas) - Free Entry Information by phone/WhatsApp (19) 3521-2121 or by email upa@unicamp.br Delegation learned about research carried out at Unicamp and expressed interest in international cooperation The show class with chef and gastrologist Tibério Gil on the role of nutrition and gastronomy in contemporary women's health opened the program that runs until Friday (8) the occupation of command positions is still unequal between men and women with six places offered each year in the first two periods; the offer increases to nine beneficiaries in the following two years The publications are divided in a didactic manner into the themes General Women's Health Obstetric Health and Adolescent Women's Health a political commitment in favor of the solution is necessary and the Brazil can play an extremely important role in global environmental solutions the sociologist was president of the National Association of Postgraduate Studies and Research in Social Sciences in the 2003-2004 biennium Webmail Wi-Fi networks User Services Charter Information Security Policy Italy) is an Italian-Brazilian curator and researcher living in Lisbon Philosophy and Economics (P.P.E) from LUISS Guido Carli University in Rome and studied Culture Studies at U.C.P in Lisbon Since 2019 he is the director of Monitor Lisbon Recent curatorial projects include the exhibitions Don't Believe in Modern Love by Lucrezia de Fazio at Rua das Gaivotas 6 (2019) Para Sempre Prestes a Terminar by Carolina Serrano at Galeria Foco (2020) Subscribe to the Newsletter (EN Version)! I accept the Privacy Policy Subscribe Umbigo Read today's Portuguese stories delivered to your email take me (to my second) home.’ - Words by Filipa van Eck Maxwell An early departure from Portugal’s effervescent capital Our day-bags are packed - bathing suits are essential Prepare to be left breathless as you take in views of the river Tagus Luisa Sobral’s “Maria do Mar” is stretching her wings and ready to soar through the radio We have our playlist ready as Lisbon disappears in our review mirror: Zambujo Bethânia and the ever-iconic Amalia Rodrigues Join us on this journey from Lisbon to the bohemian chic villages of Comporta and Melides and then on to the vineyards and olive groves of Montemor-o-Novo A road trip of a lifetime where the journey is almost as beautiful as the destinations themselves This is a triangle we’d choose to get lost in Lisbon has been the leading lady in Portugal for many seasons Not only is the capital city steeped in history and charm but it has had a re-awakening of sorts in recent years The renovation of historically significant buildings has given Lisbon an intangibly cool edge that appeals to all - from digital nomads to retirees from around the world has been a believer in Lisbon’s magic for several years now He has added an impressive roster of apartments Much of Lisbon’s magic lies in this ideal combination of modernity and tradition and colourful tiles that adorn the exteriors of buildings Lisbon is fast making a name for itself in international food circles The world has discovered Lisbon in all its glory but where do locals and foreigners in-the-know go to escape One hour south of Lisbon lie the beach villages of Comporta and Melides their quiet sophistication has long attracted renowned artists Even Christian Louboutin has chosen Melides as a place to kick off his heels The French designer has recently launched a hotel named Vermelho (red) inspired by his signature red-soled shoes Comporta and Melides are located on the West Coast of Alentejo and form part of the Sado Estuary One can spot over 200 bird species in the estuary wildflowers and olive trees surround the collection of villages that make up the Comporta region The self-proclaimed epicenter being Comporta Village This is a place where the traditional farmer’s and fishermen’s huts are celebrated Perhaps the most appealing thing about this region is the anonymity it affords even the most famous celebrities there is nothing plain about the region’s gastronomy and boutiques Cavalariça and JNcQUOI are firm favourites with locals and foreigners alike the beaches are the most fragrant of cinnamons on top of this delicious “pastel de nata” Untouched coastline as far as the eye can see Luiz has a profound understanding of the region and what it is that makes something prestigious He has cherry-picked several Villas for consideration Several of them located in a high-end resort named Spatia (space or room in Latin) Developments in the area are very carefully planned to preserve this feeling of serenity and seclusion The architecture at Spatia is contemporary with a nod to Comporta style always with large windows and high ceilings that invite nature in at every turn The five-star services and amenities allow one to erase maintenance headaches out of the country homeownership equation The only logistics to consider are how best to relax Nowhere else in Europe does coastline development feel so private all a short buggy ride to an immaculate beach Our favourite stretch of road in Portugal is the drive from Comporta into rural Alentejo might be a good choice of soundtrack for this section of the roadtrip Meander in smooth zigzag motion – ethereal beauty at every turn - an ancient cork tree the sun running its fingers through the grass wildflowers’ choreographed dance in the breeze one for those who love to be alone with their thoughts The third location in our timeless trinity is Montemor-o-Novo grow on a tranquil south-facing valley with the medieval castle of Montemor on the horizon Montemor region is well-known for its full-bodied red wines Cabernet Sauvignon and Syrah varieties of grape all thrive here Alentejo is the best-preserved region of Europe menhirs and dolmens - some dating back to Upper Palaeolithic times Amongst the olive groves and orange orchards lies an exclusive retreat and a five-star hotel very close to Luiz’s heart - L’AND Vineyards The design concept is ‘Mediterranean Patio-Living’ - patios that feel like private oases and represent the core of the home “Introverted” yet unfurling into the surrounding countryside The awe-inspiring developments encourage stargazing and residents can even produce their own wines with the help of skilled enologists but Montemor is only 45 mins to Lisbon Airport Short trips within the region are greatly encouraged Alentejo’s cuisine is comforting and hearty Wine tours are recommended for connoisseurs and amateaur wine drinkers and Quinta do Quetzal rank highly on our list How about ending the day with a hot air balloon ride We are heading back towards Lisbon and her famous red bridge that welcomes us with open arms Cristo Rei statue mirroring this gesture time and time again it is always a treat seeing your twinkling lights A galaxy of nighttime reflections in the river below We might have arrived back in time for dinner and drinks in Principe Real Maia International Properties is much like Portugal - 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