Please enable JS and disable any ad blocker Joao Moreira completed a Classic double within the space of a week when guiding Museum Mile home in front of hotly-tipped fellow Sunday Racing runner Croix Du Nord in Sunday's Satsuki Sho (Japanese 2,000 Guineas) at Nakayama Croix Du Nord was an odds-on favourite and had appeared yet another emerging superstar for his sire when taking the Grade 1 Hopeful Stakes at the end of the year but was facing his biggest assignment to date without a prep-run Faust Rasen made what has become his trademark move in slicing through the field to dictate the pace mid-race but as the field turned in Moreira challenged from deeper and ended up winning quite comfortably by a length and a half even when having to catch a briefly dropped rein close home Museum Mile is a second Grade 1 winner for his sire Leontes a top-class juvenile by the legendary King Kamehameha and out of Japanese and American Oaks winner turned fabled producer Cesario Leontes has sired the consistent T O Royal who won the valuable Saudi Derby when it was a conditions race in 2021 He is standing at the Breeders Stallion Station in Hokkaido for a fee of Y4,000,000 (£21,000/€25,000) Museum Mile has now won three races and is the first foal out of minor scorer Museum Hill who has a two-year-old daughter by Leontes' three-parts brother Saturnalia named Festival Hill and a yearling colt by Lord Kanaloa Moreira said: "He showed great speed at the straight I'd like to thank everyone at the stables for keeping him in such good condition I felt his strength the moment I rode him at the paddock He was in good mental condition during the race so I don't think there's any problem with a longer distance." Croix du Nord's rider Yuichi Kitamura was disappointed and apologetic: "I'm sorry to everyone who supported me that I couldn't win," he said "I thought I was in the best position going into the corner but when other horses came from behind I hope he'll do his best again next time." Moreira had earlier guided an Australian import by Al Shaqab shuttler Shalaa to a Listed victory in the Keiyo Stakes was bought for A$200,000 at the 2023 Inglis Easter Yearling Sale ‘This is crazy’ - Tattersalls record tumbles as 1,400,000gns Acclamation colt brings huge pinhooking profit  'Now we can dream a bit more' - Zia Agnese strikes first Group success for Romanised  Published on 20 April 2025inInternational Copyright © 2025 Spotlight Sports Group Limited or its licensors, all rights reserved Evaluating the effectiveness of Chagas disease treatment poses challenges due to the lack of biomarkers for disease progression and therapeutic response. In this study, we aimed to assess the clearance of Trypanosoma cruzi (T. cruzi) parasites in a group of benznidazole (BNZ)-treated chronic Chagas disease patients using high-sensitivity quantitative PCR (qPCR) and track T. cruzi antibody levels through a semiquantitative chemiluminescent assay. Our study suggests that serial PCR results pose challenges in interpretation. In contrast, serial antibody levels may serve as an ancillary, or even a more reliable indicator of parasite decline following BNZ treatment. Monitoring antibody levels can provide valuable insights into the efficacy of treatment and the persistence of parasites in Chagas disease patients. Volume 2 - 2023 | https://doi.org/10.3389/fpara.2023.1235925 This article is part of the Research TopicPolymerase Chain Reaction technique for Chagas Disease: challenges and limitationsView all 6 articles Background: Evaluating the effectiveness of Chagas disease treatment poses challenges due to the lack of biomarkers for disease progression and therapeutic response we aimed to assess the clearance of Trypanosoma cruzi (T cruzi) parasites in a group of benznidazole (BNZ)-treated chronic Chagas disease patients using high-sensitivity quantitative PCR (qPCR) and track T cruzi antibody levels through a semiquantitative chemiluminescent assay cruzi seropositive patients with previous PCR-positive results were enrolled in the study We collected samples 30 days before treatment (T-30d) on the day before initiating BNZ treatment (T0d) and 36 months (T36M) after treatment initiation Treatment efficacy was assessed by testing of serial samples using a target-capture qPCR assay specific to satellite T cruzi ELISA Test System for antibody quantitation 87 completed at least 50% of the treatment course and 86 had PCR results at follow-up visits T6M PCR results exhibited fluctuations before and after treatment but levels were significantly lower post-treatment Only 15 cases consistently tested PCR-negative across all post-treatment visits nearly all participants demonstrated a declining antibody trajectory with patients who tested PCR-negative at T36M exhibiting an earlier and more pronounced decline compared to PCR-positive cases at the same visit Conclusion: Our study suggests that serial PCR results pose challenges in interpretation serial antibody levels may serve as an ancillary or even a more reliable indicator of parasite decline following BNZ treatment Monitoring antibody levels can provide valuable insights into the efficacy of treatment and the persistence of parasites in Chagas disease patients Benznidazole (BNZ) is the primary treatment available for Chagas disease worldwide. The evidence base supporting treatment with BNZ comes primarily from retrospective observational studies that have documented a reduced rate of progression to cardiomyopathy and lower mortality in BNZ-treated patients (Cardoso et al., 2018; Hasslocher-Moreno et al., 2021) We present the three-year follow-up results of a prospective cohort of BNZ-treated chronic Chagas disease patients We aimed to characterize the parasite clearance rate using a high-sensitivity quantitative qPCR assay and describe the trajectory of anti-T cruzi antibody levels throughout early treatment and long-term follow-up relative to parasite persistence by PCR as a marker of therapeutic response and most were followed for three years following treatment with longitudinal clinical assessments and characterization of persistence and levels of T *All follow-up PCRs are depicting those drawn after BZN treatment We collected medical data and blood samples at multiple intervals 30 days prior to the BNZ treatment (T-30d) Another round of data collection occurred on the day before treatment initiation (T0d) We then gathered follow-up data at 60 days (T60d) and thirty-six months (T36M) post-treatment initiation At the enrollment interview and follow-up visits 12mL of blood anticoagulated with ethylenediaminetetraacetic acid (EDTA) was collected and immediately mixed with an equal volume of 6M guanidine/HCl-0.2M EDTA solution for PCR Serum separator tubes (SST) were also collected at each visit and centrifuged at 3000G for 15 min and serum aliquots were frozen at -20°C Aliquots of guanidine-lysed blood and serum were shipped to the US Central Laboratory (VRI; previously BSRI) for qPCR and serology Data from each patient were uploaded into REDCap (Research Electronic Data) (Harris et al., 2009; Harris et al., 2019) and results were then de-identified from specific patient-sensitive information We assessed changes in parasite loads measured through qPCR and serology levels by comparing the differences between the levels at multiple time points (T0d Our defined outcomes were as follows: “Negative” indicated a negative PCR result at T6M and T36M; “Positive” indicated a positive result on the T36M visit regardless of the earlier results; and “Inconclusive” referred to patterns that were negative on the T36M visit but had at least one PCR positive result at T6M or T12M visits we classified them as “Inconclusive” we conducted a multinomial logistic regression with the Negative group as the reference considering the age at study initiation and sex We presented these outcomes graphically using a serial boxplot to show the trend across visits regarding the antibody levels between these groups To predict the likelihood of experiencing a “Non-Positive PCR outcome,” which includes the Negative and Inconclusive groups we conducted a logistic regression with “Positive” as the reference category The models were adjusted for the same variables as in the multinomial analysis We presented the associations between predictor variables and the outcomes using odds ratios (OR) with 95% confidence intervals (CI 95%) we employed paired Wilcoxon rank-sum tests and Chi-squared tests with Bonferroni adjustment post-hoc for comparison across visits and the T0d visit We used the Kruskal-Wallis test to analyze the differences in antibody levels across visit time points and outcomes for T cruzi-infected patients treated with benznidazole Continuous variables were reported as medians and interquartile ranges or mean and standard deviations based on their distribution while categorical variables were reported as frequencies and percentages Our conclusions are based on a two-tailed hypothesis test with an alpha error probability of 0.05. We performed the statistical analysis and generated graphics using R Studio software (version 4.2) (RStudio, 2022) This study protocol was approved by the local ethics committee of the Hospital of Clinics and Institute of Infectology “Emilio Ribas” (CAAE00580612.8.0000.0065) All patients provided written informed consent at the time of recruitment Table 1 Clinical characteristics of the subjects that completed at least 50% of the BZN course Table 2 PCR and serological results of Chagas patients completing at least 50% of the treatment course with benznidazole Figure 2 Dotplot representing individual Polymerase Chain Reaction (qPCR) measurements for 85 subjects treated with benznidazole with at least three follow-up PCR measurements while the red bars indicate the 95% confidence interval around the mean Note the different scales in the two segments of the y-axis Similar trends were observed at the T12M and T6M visits was associated with a 60% reduction in the odds of being classified as part of the Positive outcome group a 1-unit decrease in Ab levels resulted in approximately a 51% decrease in the odds of being classified as part of the Positive outcome group the drop in S/CO between T-30d and T60d is predictive of the outcome at the T36M visit the CI95% was too large to rule out the possibility of no effect Figure 3 Forest plot depicting the Multinomial Logistic Odds Ratio for the positive outcome group with negative as the reference category CI: Confidence Interval; S/CO: Signal-to-Cutoff.T0d: Time 0 day; on the day at benznidazole treatment initiation T60d: Time 60 days; follow-up visit 60 days after initiating benznidazole treatment T6M: Time 6 Months; follow-up visit 6 months after initiating benznidazole treatment; T12M: Time 12 Months; follow-up visit 12 months after initiating benznidazole treatment T36M: Time 36 Months; follow-up visit 36 months after initiating benznidazole treatment Our study also investigated the association between qPCR results, antibody levels, and the probability of attaining a Non-Positive outcome comprising Negative or Inconclusive results. The results revealed a consistent trend of higher success rates in parasite suppression over time, with the likelihood more than doubling at the T36M visit compared to earlier time points among those presenting the reference category as “Positive” (Figure 4) Figure 4 Forest plot depicting the Binomial Logistic Odds Ratio for the non-positive result (negative or inconclusive) outcome group with positive as the reference category T0d: Time 0 day; on the day at benznidazole treatment initiation Figure 5 Forest plot depicting the Multinomial Logistic Odds Ratio for the inconclusive outcome group with negative as the reference category Figure 6 Serial boxplot over visits depicting Decaying Serological Values (S/CO): from Baseline across follow-up visits between defined outcomes Non-Positive Outcomes (negative or inconclusive) S/CO: Signal-to-CutOff; T0d: Time 0 day; on the day at benznidazole treatment initiation T6M: Time 6 Months; follow-up visit 6 months after initiating benznidazole treatment T12M: Time 12 Months; follow-up visit 12 months after initiating benznidazole treatment Figure 7 Serial boxplot over visits depicting Decaying Serological Values (S/CO): from Baseline across follow-up visits between defined outcomes: Combined PCR outcome (T6M respectively: Negative (negative result in all visits); Positive (positive result at the T36M visit regardless of the previous results); Inconclusive (negative result at the T36M visit and at least one positive result at T6M or T12M) Figure 8 Individual Serological values (S/CO) trajectories from Baseline across follow-up visits between defined outcomes: Combined PCR outcome (T6M The PCR results we obtained were challenging to interpret primarily when used to determine complete parasite elimination Most patients still showed detectable levels of PCR at least once post-treatment even though these levels were significantly lower than before treatment we observed a consistent and early decrease in antibody levels especially in those patients classified as the ‘Negative’ group While qPCR levels showed a decline across all treatment time points we agree that these levels should not be regarded as a standalone marker for treatment effectiveness This is because the qPCR levels did not differentiate between the treatment groups at individual time points our study revealed that participants with a >1 S/CO drop at T12M were all negative on PCR at the three-year mark indicating that an early decrease in antibody titers may be an early predictor of long-term parasite clearance and treatment success our study highlights the challenges of interpreting T It suggests that antibody decline detected by chemiluminescent assay may be a valuable marker for BZN therapeutic response Further follow-up visits are necessary to fully understand the long-term response to BZN treatment considering the association of such parasitological outcomes and antibody dynamics The original contributions presented in the study are included in the article/Supplementary Material Further inquiries can be directed to the corresponding author The studies involving human participants were reviewed and approved by Ethics committee of the Hospital of Clinics The patients/participants provided their written informed consent to participate in this study Writing – Original Draft Preparation: CM Writing – Review & Editing: all authors All authors contributed to the article and approved the submitted version This project has received funding from Bill and Melinda Gates´ foundation under grant n° OPP1071295/Subagreement 7636 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) N° 467043/2014-0 the Institute of Infectology “Emilio Ribas,” and HCFMUSP employees especially the nurses and laboratory staff: Aparecido Braz Author SM was employed by the company GigaGen - A Grifols Company Author SC was employed by the company Grifols Diagnostic Solutions Author PC was employed by the company Ortho-Clinical Diagnostics The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The authors declare that this study received funding from Bill and Melinda Gates Foundation The funder was not involved in the study design or the decision to submit it for publication All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpara.2023.1235925/full#supplementary-material Brazilian Ministry of Health (2022). Available at: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/d/doenca-de-chagas/situacao-epidemiologica (Accessed July 13 Google Scholar Declining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n ajente etiolojico de nova entidade morbida do homem Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease The REDCap consortium: Building an international community of software platform partners Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support Hasslocher-Moreno A Benznidazole decreases the risk of chronic Chagas disease progression and cardiovascular events: A long-term follow up study Randomized trial of posaconazole and benznidazole for chronic Chagas’ disease Randomized trial of benznidazole for chronic chagas’ Cardiomyopathy Benznidazole and posaconazole in eliminating parasites in asymptomatic T Drug repurposing in chagas disease: chloroquine potentiates benznidazole activity against Trypanosoma cruzi in vitro in vivo Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas Requena-Méndez A. Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysis RStudio (2022) RStudio: integrated development for R (Boston Google Scholar Detection of Trypanosoma cruziDNA in blood by PCR is associated with Chagas cardiomyopathy and disease severity Ten-year incidence of chagas cardiomyopathy among asymptomatic trypanosoma cruzi–seropositive former blood donors doi: 10.1161/CIRCULATIONAHA.112.123612 Sánchez-Valdéz F Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure CrossRef Full Text | Google Scholar Usefulness of real-time PCR during follow-up of patients treated with Benznidazole for chronic Chagas disease: Experience in two referral centers in Barcelona New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2 Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept proof-of-concept trial of oral fexinidazole in adults with chronic indeterminate Chagas disease Busch MP and Sabino EC (2023) Parasitemia and antibody response to benznidazole treatment in a cohort of patients with chronic Chagas disease Received: 06 June 2023; Accepted: 01 August 2023;Published: 05 September 2023 Copyright © 2023 Moreira, Bierrenbach, Taconeli, de Oliveira-da Silva, Buss, Keating, Manuli, Carvalho, Guastini, Coco, Lindoso, Franco, Ghilardi, Sales, Contestable, Di Germanio, Busch and Sabino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Ester Cerdeira Sabino, c2FiaW5vZWNAZ21haWwuY29t †These authors share senior authorship Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish French club will pay sister side just over £1.5m for Portuguese Sport | Football featuring team news and expert analysis from Malik Ouzia I would like to be emailed about offers, event and updates from Evening Standard. Read our privacy notice Chelsea have confirmed the sale of Diego Moreira to Strasbourg The French team are reportedly paying around £1.7million for the 20-year-old who made just one appearance for the west Londoners since arriving on a free transfer last summer A buy-back clause has been inserted into the deal for Moreira in what has been described as a workaround for the spate of transactions between the BlueCo sister clubs Strasbourg can only loan three players at any one time from Chelsea and signed both Caleb Wiley and Andrey Santos on temporary deals earlier in the summer The final spot could go to Djordje Petrovic who has been named as a possible candidate to spend time with the Ligue 1 club after falling out of favour with Enzo Maresca Moreira could therefore return to Stamford Bridge later in his career although he has done little to suggest he will make the grade after an underwhelming loan spell at Lyon last season VE Day 2025 fashion: best looks from the day VE Day 2025 fashion: Princess of Wales to Lady Victoria Starmer Prince Louis steals the show at VE Day parade as he keeps dad William looking sharp and mimics brother George Prince Louis steals show with sweet antics at VE parade Ukraine 'launches stunning Kursk offensive' in major blow for Putin ahead of Victory Day celebrations Ukraine 'launches stunning Kursk offensive' in blow for Putin New visa crackdown as Home Office plans to restrict applications from nationalities most likely to overstay New visa crackdown as Home Office plans to restrict applications BBC admits to ‘lapse’ in standards after Today coverage of Harry interview The Cartier space was reopened to visitors in June and closed again n September This month, the winners of the Right Livelihood Award were announced by the eponymous foundation. The prize has come to be known as the “Alternative Nobel.” Davi Kopenawa was one of them He was cited by the jury for “his courageous determination to protect the forests and the biodiversity of Amazonia as well as the lands and culture of its indigenous peoples.” He was the only male recipient Three female activists were also chosen last week: the Swedish teenager Greta Thunberg who mobilized four million climate demonstrators around the world Sahrawi human rights defender Aminatou Haidar Yanomami leader Davi Kopenawa shared the prize of one million Swedish crowns (US$180,124) with the Hutukara Yanomami Association which he co-founded and has run since 2004 to divulge his people’s culture The words and teachings of the shaman Davi Kopenawa, revealed in A Queda do Céu (The Falling Sky), which he wrote with anthropologist Bruce Albert, inspired the Yanomami and Ye’kwana Leadership Forum to produce the film A Mensagem do Xamã (The Shaman’s Message), which debuted in mid-November (viewable here) With a running time of just over two minutes, narrated in the Yanomami language by Dário Kopenawa, Davi’s son, the film is a condensation of his reflections and spearheads the #ForaGarimpoForaCovid (#OutMiningOutCovid) campaign which requests that the Brazilian government immediately withdraw the illegal miners from designated tribal territories and combat COVID-19 During the meeting to denounce illegal mining of their lands which also included chiefs of the Munduruku and Kayapó peoples the two leaders handed over a list of 438,000 signatures collected in an online petition to federal deputies The “Xawara report on the advance of Covid-18 in the Yanomami Indigenous Land and the State’s omission,” compiled recently was also sent to executive and judicial authorities The #OutMiningOutCovid campaign launched an open letter in November The delivery of the petition and the report in Brasília ended the campaign which featured projections of the beautiful designs and words of artist Joseca Yanomami on the cupolas and towers of the Senate and the Chamber of Deputies but the struggle continues with the added and important reinforcement of Davi Kopenawa’s admission to the Brazilian Academy of Sciences as a collaborative member May this partnership be long and prosperous And may it bring many fruits for his people and for all the indigenous peoples of Brazil Translated for People’s World by Peter Lownds from the original publication by Instituto Socioambiental Shinnecock tribe continues battle for right to build on their land... Lula da Silva: multilateralismo y cooperación internacional como respuesta al cambio... ‘Water for Life’: Lives on the line ‘Sinners’ review: Horror, history, and Black American folklore combine for trailblazing cinema  Amidst capitalist crisis and war, Russian Communists struggle against Putin and the oligarchs Houston schools vs. corporate reform: Fighting the commodification of learning U.S. imperialism’s new Cold War against China fosters anti-Asian racism at home Chickens coming home to roost: Remember what Malcolm said but Chelsea have actually got rid of so many players during a very busy summer transfer window Yes, the Blues were busy yet again signing new faces for their squad It was reported by journalist Rahman Osman via X that Chelsea youngster Alex Matos agreed a move to La Liga but the deal to join Getafe wasn’t registered in time and collapsed Chelsea’s transfer chiefs did well to sell a number of individuals in the summer there’s clearly been a focus to shift on academy graduates to help balance the books Here is how we’ve rated every outgoing sale at Chelsea in the 2024/25 summer window… Chelsea sold Ian Maatsen to Premier League rivals Aston Villa in a deal worth £37.5m (Sky Sports) which certainly has both its positives and negatives from a Blues perspective The 22-year-old left-back is a quality player something he proved out on loan with Borussia Dortmund selling him to a league rival feels frustrating because he’s more than enough to impact the current squad at Stamford Bridge the club has received a very healthy transfer fee from the deal you’ll see below that the club have been selling academy graduates to help themselves financially so Maatsen’s one of several caught in that particular crossfire The sale of Conor Gallagher to Atletico Madrid this summer certainly divides opinion Yes, Chelsea made pure profit on selling the box-to-box midfielder for £33m (BBC) It’s a relief that he was shipped overseas rather than to a direct rival we’ve got to rate this transfer sale low for a couple of main reasons the Blues have significantly downgraded by replacing Gallagher in the squad with Kiernan Dewsbury-Hall the academy graduate was the club’s second best player behind Cole Palmer last season so selling him is quite baffling if you park the financial explanation At first, Napoli’s £30m signing (BBC) of Romelu Lukaku feels a bit low for Chelsea when you consider how much he originally cost the Blues it’s such a relief for everyone that the 31-year-old striker is finally off the club’s books after years of turmoil this is the Blues hierarchy clearing up the mess of the previous ownership Lewis Hall spent last season on loan with Newcastle United, but his permanent move in a £28m deal (BBC) to St James’ Park only officially went through this summer It feels like a pretty large transfer fee for a versatile 19-year-old player still developing his game This is one that the Blues may revisit and think they got wrong at a later date This could be one transfer sale that Chelsea look back at with some major regret further down the line Premier League new boys Ipswich Town signed Omari Hutchinson in a £20m deal (BBC) which based on the early weeks of the season looks like a great investment for the East Anglian side The 20-year-old right-winger was tremendous in the Championship last during a loan with Ipswich He’s now proving he’s ready for the top division and his potential does look quite frightening It feels like the club may have cashed in on this youngster too early The Blues managed to convince Leicester City to pay £4m (BBC) to sign Michael Golding this summer which isn’t a bad price for a youngster with so little experience The 18-year-old midfielder has developing in Chelsea’s youth teams in recent years even making one first-team appearance for the senior squad He was hardly an individual earmarked for greatness Chelsea sold Diego Moreira to sister club Strasbourg for a very cheap price of £1.7m but there’s been a mention of a buy-back clause The 20-year-old attacker certainly has shown he’s got potential It’ll be interesting to watch his development this year We don’t blame Chelsea fans if they forgot Hakim Ziyech was still their player this summer There’s not much to say other about his move to Galatasaray on a free transfer other than it’s good he’s off the wage bill He certainly didn’t live up to the hype during his time in west London… Like Ziyech, Chelsea centre-back Malang Sarr also left the club on a free transfer The 25-year-old French defender has returned to his homeland to join Ligue 1 side Lens where hopefully he can play regular football again Tino Anjorin completed a move to Italian Serie A club Empoli on a free transfer late in the summer window Interestingly, Football.London reported that Enzo Maresca personally played a role in Anjorin’s sale who’s been on Chelsea’s books since a youngster needs to find a permanent home to go and fulfil his potential It feels like a smart deal this for all parties Finally, Chelsea announced this week that they’ve sold Angelo Gabriel to Saudi Pro League club Al-Nassr in a £19.1m deal (BBC). The 19-year-old winger didn’t feature in Maresca’s plans this campaign, so he’s got a last-minute transfer exit to Saudi Arabia. It gets a positive rating this deal because the Blues have made a profit, plus Angelo’s path into the first-team squad was pretty blocked. Text description provided by the architects. Project for a Museum on Paulista Avenue- the new IMS of São Paulo. The creation of a new museum is always an extraordinary event. It is fundamental the role they play in contemporary cities, not only for promoting events related to art and culture, but especially for bringing interest and vitality to urban spaces. The Paulista Avenue is one of the few places in the city where we find a huge variety of people and programs living in one place. One of the few places where we have a mixed, plural and more democratic city. This rare quality, coupled with the generous scale and the privileged geographical situation, makes Paulista Avenue one of the most interesting and lively spaces in São Paulo. © Nelson KonThe warehouses and other areas of support to the museum - such as the temporary storage space for works of art, library collections and varied stocks - are in the 2nd underground. This floor is connected to the rest of the building by means of a large cargo lift and a set of elevators and stairways restricted to staff and technical personnel. there is the question of how the building is placed in the city The use of translucent glass as second skin causes the museum to be perceived as a well-defined volume with the necessary force to establish its place among the neighbors and other buildings of Paulista Avenue its properties of light and translucency create for the building a second register which is changeable depending on the nature of the environment and the position of the observer the interior of the museum is subtly manifested in urban space You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email Shoppers fill Mount Pleasant Towne Centre on Nov 19 ahead of the official start of the holiday shopping season on the day after Thanksgiving 19 at Mount Pleasant Towne Centre ahead of the official start of the holiday shopping season on Black Friday The holiday shopping season is well underway and locally owned merchants such as The Station in North Charleston's Park Circle area remind people to shop and dine locally during the holiday season The National Retail Federal projects holiday spending in November and December will increase 6-8 percent this year Roommates Raegan Whiteside (standing) and Aubrey Moreira of James Island pick out ornaments at Target in West Ashley to finish decorating their Christmas tree which they decided to put up two weeks before Thanksgiving The National Retail Federation predicts holiday sales will rise 6-8 percent this year even as shoppers face painfully high inflation Charleston merchants don't believe higher prices will inflict too much damage on the shopping season as they believe sales will be robust retailers face a new issue during the holiday season disruptions in the supply chain meant some merchants couldn't get all the goods they needed to keep up with demand though it did slip slightly in early November after reaching a 40-year high during the summer Challenges during the past two years didn't dent sales as the federal government flooded the economy with free money in the wake of the coronavirus lockdowns merchants expect this year's holiday season to ring up merry sales again "We are expecting robust demand and good sales," said Beezer Molten CEO of North Charleston-based outdoor gear chain Half-Moon Outfitters "There is a lot of talk about a lot of inventory being out there and it may be true for some of the big chain stores but it might not always be true in our curated items," Molten said He also said the shipping supply problem is not a factor this year he doesn't expect it to be an outsized component of overall sales but it could play a role in the kinds of purchases people make "I think people will be more cautious in how they spend their money and it might be a different price point from last year," he said At downtown Charleston men's clothing store Grady Ervin & Co. owner Chip Ervin expects a brisk holiday shopping season "We are tracking ahead of last year and believe we are going to see a positive shopping environment going into December and the beginning of the new year," he said Ervin pointed to higher prices on the clothing lines he carries because shipping container companies passed along higher rates this year after absorbing them last year higher interest rates and increased fuel costs have had a negative effect on the overall economy but Ervin said the Charleston market "still proves to be a little resilient" because of tourism and an influx of new residents "Some people have tightened their purse strings a little bit He pointed to new challenges merchants face every year but he said shopowners continue to evolve to meet them head on "Retailers have to be resilient and pivot quickly We are still seeing some supply-chain issues co-owner Billy Richardson hopes for another good season after the past two years of record sales but he's seeing transactions trend to what he called "back-to-normal He also is unsure how the shopping season will play out with inflation biting into buying power this year "The availability of products is coming back online "Inflation is causing some categories to fall stale Fitness categories are down because the price has doubled." He also noticed many shoppers tend to browse through the Thanksgiving holiday weekend and then wait for items to go on sale "It will be intriguing to see how this season goes." the Mount Pleasant Chamber of Commerce will give away a $100 gift card to one lucky shopper who posts a photo of his or her purchase from a participating Mount Pleasant business on Instagram and tags the location @mtpchamber and @experiencemp Each gift card will be from the patronized business It's part of the second annual promotion by the chamber and the town called "Shop Where You Live." It runs Nov go to the chamber's Facebook page starting on Black Friday The National Retail Federation predicts holiday spending during November and December will surge 6 percent to 8 percent higher than the record set last year the trade group says the average shopper will spend about $1,000 on gifts and other holiday items with total spending this year soaring to nearly $960.4 billion "While consumers are feeling the pressure of inflation and higher prices (they) remain resilient and continue to engage in commerce," said Matthew Shay president and CEO of the nation's largest retail trade group which are included in the total projection is expected to grow between 10 percent and 12 percent to as high as $268 billion That's up about $30 billion from last year when consumers turned to click-and-order sales during the pandemic The surge in online spending is expected to continue but the retail trade group also believes consumers will shift back this year to a more traditional experience of in-store shopping in the wake of the health crisis retailers foresee a "generally positive" overall outlook for holiday spending “This holiday season cycle is anything but typical,” said Jack Kleinhenz rising interest rates and low levels of confidence consumers have been steadfast in their spending and remain in the driver’s seat." Some discount stores and pharmacies will be open on Thanksgiving Day while most retailers will not open until Black Friday a change during the past couple of years after a backlash from consumers and others Check with your local retailer for up-to-date store hours believe they will spend about the same as last year between $1,000 and $1,500 on gifts and the trappings of Christmas A good chunk of it will be spent on shoes and clothes for their daughter "She is going through a growth stage," Stacey said Neither of the parents plans to be in stores on Black Friday but they also want to stay away from what they called "the craziness and the crowds." Roommates Aubrey Moreira and Raegan Whiteside of James Island also said high inflation won't affect their spending this year who works in accounts payable for a transportation company expects to spend about $800 on gifts and other holiday items who is employed in accounting in the medical field believes her Christmas season outlay will come to about $500 "I don't like the lines," Moreira said while shopping with Whiteside at Target in West Ashley for ornaments to fill in a few gaps on their Christmas tree Mimi Castillo of Summerville also won't trim back on spending because of the higher cost of goods the construction worker plans to spend close to $5,000 on her many nieces and nephews through gift cards "I will probably spend more than last year because of inflation," she said "Everything is so much more expensive now." As for shopping on the day after Thanksgiving Reach Warren L. Wise at wwise@postandcourier.com News tips/online questions: newstips@postandcourier.com Delivery/subscription questions: subserve@postandcourier.com Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Subscribe Moreira Salles’ single family office sees boost in AUM to nearly $11 billion The family office of the Moreira Salles family boosted its assets under management to nearly $11 billion while adding staff one of Brazil’s largest single-family offices added 5.4 billion reais ($1.1 billion) in assets last year as it raked in dividends from its banking and mining businesses,” according to a report by Bloomberg “The Sao Paulo-based firm also grew its headcount to 78 employees from 69 the year prior.”  “BWGI has been increasing its workforce to adapt to the new markets that it’s begun to operate in,” the Moreira Salles family said in a statement “It’s worth highlighting the growth in the technology team to support the increase in new resources.”  which is currently run by 42-year-old former JPMorgan Chase investment banker Joao Moreira Salles Thanks to a co-controlling stake in Itau Unibanco Holding SA the family has a collective net worth of $27.9 billion according to the Bloomberg Billionaires Index “The roots of the family’s fortune were laid in 1924 The lender financed the expansion of coffee plantations in the 1930s and 1940s “His son Walther gradually built the lender into the banking giant known as Unibanco It was already one of Brazil’s largest financial institutions when it was bought by Itau in 2008 BWGI was founded the same year to manage the family’s money the world’s biggest miner of a rare-earth metal called niobium that’s used to strengthen steel products Europe and Singapore and sells the metal to some 40 countries the most recent year for which earnings are available the closely held company reported 4.5 billion reais of profit on 11 billion reais of sales Joe Lewis likely to be spared prison time after pleading guilty to fraudBritish billionaire Joe Lewis is likely to be put on probation who holds a number of assets mainly through his Tavistock Group investment portfolio believes that his co-operation with prosecutors are among the factors that weigh in favour of probation over prison The former majority owner of ENIC Group and one-time majority owner of Tottenham Hotspur Football Club had previously admitted in a Manhattan federal court to three counts of securities fraud “US prosecutors had charged him with passing inside corporate information to his private pilots and his girlfriend prosecutors agreed not to oppose a sentence lower than the range suggested under federal sentencing guidelines of 18 to 24 months in prison “His lawyers offered another reason to keep him out of prison: As a foreigner Mr Lewis would not be eligible to serve time in a prison camp with a dormitory setting but instead would be sent to a higher-security facility with ‘a more dangerous inmate population’.” Lewis is due to be sentenced on April 4 by US District Judge Jessica Clarke which has stakes in more than 200 companies helped him and his family to grow a combined net worth of $7.2 billion Michael Dell unloads shares in Dell TechnologiesThe family investment office of Michael Dell has sold a raft of Dell Technologies’ stock totaling more than four million shares Dell follows a growing number of tech billionaires who have recently sold parts of their companies - including Mark Zuckerberg While he still owns half of the Texas-based company the largest asset behind his $99.7 billion fortune according to the Bloomberg Billionaires Index he is believed to have put the shares up for sale as artificial intelligence optimism grows “Dell’s shares jumped 32 per cent on March 1 to a record high after the company reported sales and profit that beat analysts' estimates fueled by demand for technology that can support AI applications,” read the Bloomberg report “The stock has gained 52.48 per cent so far this year and is currently trading in the $114 range.” The 59-year-old billionaire founded Dell Technologies in 1984 while he was a student at the University of Texas CampdenFB.com is a wholly owned subsidiary of Campden Wealth © 2001-2022 CampdenFB.com Your use of this site is governed by the Terms and Conditions Bruno Moreira is the used car sales manager at Fafama Auto Sales in Milford The Detroit Free Press reported last week that General Motors will be closing nearly all of its assembly plants in North America as the COVID-19 pandemic continues to affect production of semiconductor chips overseas The chips are the same used in small electronics such as laptops And with more workers and children home during the pandemic And that is emptying lots and driving up prices Moreira said he used to have about 450 used cars in his inventory "We're hurting. It's painful because we have demand but we don't have the cars," said Moreira who has sold 50 cars this year compared to 180 a year ago Moreira said due to rising prices and lack of supply the cost of a used car is sometimes higher than the cost of a new car Moreira is not alone in his frustration.  John Hadley says he has seen high demand and an incredible increase of prices on used cars at his dealership — a 20% increase in sales and a 15% to 20% increase in prices — compared to business before the pandemic.  "(Sales have been increasing) because people just can't get new ones," said Hadley and that's (also) what's driving the price of vehicles up." Hadley says the increase of prices for used cars also benefits customers because when they trade in their cars they often get more money than before.  It's happening every day with us," Hadley said adding that customers are not only coming in to buy but also to trade used cars.  Auto manufacturers hold a portion of the chip market and before the pandemic, the new vehicle business was thriving.  Now the shortage of auto chips has resulted in low inventory at new-car dealerships and that leads to increased prices for used cars.  you can sell them because there's not much inventory available," Hadley said also encouraging people to sell vehicles if needed during the current market trend who sells both new and used cars at his dealership said he has also seen high demand for used cars due to the lack of supply of new vehicles.   "Our new cars are experiencing major shortages and inventory due to microchip shortages as well as other components that are necessary to build vehicles," said Salvadore Salvadore said he has seen 10% higher sales on used cars at his dealership than what they generally see at this time of a year.  Though the dealership has managed to maintain the same inventory of used cars he said new car inventory is decreasing.  but we're having to work harder to get the vehicles to sell," Salvadore said. "We're having to branch out in other directions to try to find places to get good used cars."  O'Connell Motors, FraminghamJack O'Connell owner of O'Connell Motors in Framingham describes the high demand for used cars as a "trickle-down effect" due to new cars being tougher to come by which pushes people who might otherwise have bought a new car to buy used.  the other factor for the high demand on used cars is because people were putting off purchases during the pandemic The inventory at O'Connell Motors is about half of what it would normally have at this time of the year, O'Connell said O'Connell says there's a boost in their business for 2021 "We're definitely still in that rebound effect from 2020 when there wasn't a lot of sales being made," O'Connell said "I would say that we're probably up around 50% to 70% for our overall sales." Metrics details Intestinal mucositis (IM) is a common side effect of 5-fluorouracil (5-FU)-based chemotherapy which negatively impacts therapeutic outcomes and delays subsequent cycles of chemotherapy resulting in dose reductions and treatment discontinuation In search of new pharmacological alternatives that minimize your symptoms this work set out to study the effect of losartan (LOS) a receptor type I (AT1) angiotensin II antagonist Intestinal mucositis was induced by a single intraperitoneal administration of 5-FU (450 mg/kg) in Swiss mice 25 or 50 mg/kg) or saline was orally administered 30 min before 5-FU and daily for 4 days the animals were euthanized and segments of small intestine were collected to evaluate histopathological alterations (morphometric analysis) oxidative stress markers and genic expression of NF-κB p65 Weight evaluation and changes in leukogram were also analyzed leukopenia and reduction in villus height compared to saline group Losartan (50 mg/kg) prevented 5-FU-induced inflammation by decreasing in the analyzed parameters compared to the 5-FU group Our findings suggest that 50 mg/kg of losartan prevents the effects of 5-FU on intestinal mucosa in mice In addition to the direct cell damage by chemotherapy there is the release of mediators of oxidative stress and the nuclear factor kappa B (NF-κB) which induces the expression of cytokines proinflammatory drugs such as interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) that promote damage and rupture in the intestinal epithelium barrier the effect of losartan on 5-fluorouracil-induced intestinal mucositis has not yet been described the aim of the present study was to investigate the effect of losartan in the prevention of intestinal mucositis evaluating morphological changes in the intestine and parameters related to oxidative stress and inflammation (A) Images of histological slides stained in H&E of fragments of the jejunum of mice submitted to intestinal mucositis treated with losartan at a dose of 50 mg/kg The measurement of villus integrity is represented by dashed lines in yellow and the size of crypts is represented by dashed lines in blue jejunum and ileum were collected to measure the villus height (10 villi/lamina) Scale bars = 100 µm (B) and crypt depth measurements (C) The bars represent the mean ± SEM of 5 mice in each group 5-FU caused a pronounced loss of body weight compared to the saline control group (Fig. 3A), which was partially rescued by losartan (50 mg/kg). (A) Effect of losartan on weight loss and (B) total leukocyte count in mice with 5-FU-induced intestinal mucositis (IM) (A) Weight assessment is shown as a percentage The bars represent the mean ± SEM (n = 5) in each group #p < 0.01 versus Saline group; *p < 0.001 versus group 5-FU (Two-way ANOVA analysis of variance followed by the Tukey test) reduced the number of leukocytes compared to the saline group (**p < 0.0001) LOS 50 mg/kg significantly increased the number of cells when compared to the 5-FU group group 5-FU; **p < 0.001 versus 5-FU group and ***p < 0.05 versus 5-FU group ANOVA one-way test followed by the Tukey test 5-Fluorouracil significantly decreased the number of leukocytes in the circulating blood compared to the saline group (animals not submitted to IM) (Fig. 3B). This effect was prevented by the three different evaluated doses of losartan (Fig. 3B) Cytokines tumor necrosis factor alpha (TNF-α) (A) and interleukin 1 beta (IL-1β) (B) in the jejunal portion of mice submitted to the experimental model of intestinal mucositis (IM) The saline group comprised animals without IM; In the 5-FU group the animals received 5-FU and without treatment underwent IM and were treated with losartan (orally) The results are presented as mean ± standard error of the mean (n = 5/group) *p < 0.001 (compared to saline); **p < 0.0001 (compared to 5-FU) (ANOVA analysis of variance with the Tukey post-test) Malondialdehyde (MDA) (A) and glutathione (GSH) (B) levels in the IM model 5-FU and losartan are presented in doses of 5 The 5-FU increased the mRNA expression of TWEAK, Fn14 and NF-κB p65, compared to the Saline group (Fig. 6). Losartan prevented the mRNA genic expression of these three markers, mainly at doses of 25 or 50 mg/kg, compared to animals with IM, without treatment (5-FU) (p < 0.05). Polymerase chain reaction in real time for TWEAK Weak apoptosis inducer like cytokine tumor necrosis factor (A); FN-14 inducible fibroblast growth factor 14 (B); NF-κB p65 the nuclear transcription factor kappa B (C) 5-Fluorouracil (5-FU) increased the expression of these genes compared to the Saline group Losartan decreased the expression of TWEAK compared to the 5-FU group (n = 5); *p < 0.05 compared with the Saline group; **p < 0.05 compared with the group 5-FU; analysis of variance with Tukey's post-test) We found that 5-FU induced intestinal damage in all intestinal segments investigated loss of crypt architecture and a pronounced inflammatory cell infiltrate in the lamina propria associated with weight loss compared to the control group The body weight loss might be related to malabsorption due to intestinal lesions resulting in loss of the intestinal absorptive surface We first investigated whether losartan affected 5-FU-induced weight loss and histological alterations The highest dose of losartan significantly attenuated this injury in the jejunum and colon and partially rescued the pronounced loss of body weight caused by 5-FU Representation of pharmacological modulation of the intestinal mucositis induced by 5-fluorouracil (5-FU) treated with the losartan DNA damage due to 5-FU promotes the release of reactive oxygen species (ROS) and activates NF-κB that induces the expression of proinflammatory cytokines such as IL-1β and TNF-α which that together promote inflammation in the intestinal mucosa Losartan was reducing NF-κB p65 in response the decreased of gene expression TWEAK/Fn14 reducing IL-1β and TNF-α and decreasing oxidative stress Tumor necrosis factor (TNF)-like weak inducer of apoptosis; Fn14 Fibroblast growth factor-inducible 14; NF-κB p65 Losartan 50 mg/kg partially prevented the effects of 5-FU-induced intestinal mucositis in mice The findings of this study have to be seen in light of some limitations More research is needed to understand the immunomodulatory effects of losartan and assess the benefits and harms (side effects) of losartan for patients undergoing 5-FU chemotherapy weighing 25–30 g (mean age of 8 weeks) were housed in polypropylene boxes and kept in controlled conditions of temperature (24 ± 2 °C) 12 h light/dark cycle and access to food and water ad libitum All experimental protocols were approved by the Federal University of Rio Grande do Norte Ethics Committee on the use of Animals (CEUA 132.059/2018) and performed in accordance with the ARRIVE ethical guidelines All methods were performed in accordance with relevant guidelines and regulations the mice were euthanized with an overdose of thiopental (90 mg/kg After two weeks of acclimation to the laboratory environment Thirty five swiss mice were divided into 5 groups (n = 7 per group): saline (healthy mice that received a single intraperitoneal administration of 0.9% saline solution on the first day and oral administrations of saline starting 30 min before the saline intraperitoneal injection 5-FU (group submitted to intestinal mucositis by a single intraperitoneal administration of 5-fluorouracil (450 mg/kg) and received oral administrations of saline 25 or 50 (animals submitted to 5-FU-induced intestinal mucositis and treated with oral administrations of 5 starting 30 min before 5-FU administration and daily Tablets of losartan were macerated using a pestle and a porcelain mortar and dissolved in of saline to obtain a concentrated solution from which the different concentrations of losartan evaluated in the present study were prepared connected to the computer with an image capture program Between 5 and 10 villi and crypts were measured per slice (seven samples for each group) All morphometric measurements were performed blindly with the ImageJ® software (NIH The conversion of the measurements obtained into pixels were converted into micrometers (μm) A portion of the jejunum was stored in eppendorf vials at − 80 °C for further analysis of biological and molecular markers Tumor necrosis factor (TNF)-like weak inducer of apoptosis Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model How to feed patients with gastrointestinal mucositis 5-Fluorouracil induced intestinal mucositis via nuclear factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis Regulatory role of Lactobacillus acidophilus on inflammation and gastric dysmotility in intestinal mucositis induced by 5-fluorouracil in mice Chemotherapy-induced mucosal barrier dysfunction: An updated review on the role of intestinal tight junctions The pathogenesis of mucositis: Updated perspectives and emerging targets autophagy and ROS production in endothelial cells and cardiomyocytes anti-inflammatory and antioxidative effects in patients with high-risk hypertension Angiotensin II and inflammation: The effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade Regulation of angiotensin II receptors beyond the classical pathway The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis Padda, R. S., Shi, Y., Lo, C.-S., Zhang, S.-L. & Chan, J. S. D. Angiotensin-(1–7): A novel peptide to treat hypertension and nephropathy in diabetes?. J. Diabetes Metab. https://doi.org/10.4172/2155-6156.1000615 (2015) Telmisartan alone or in combination with etanercept improves anemia associated with rheumatoid arthritis in rats: A possible role of anti-inflammatory and reno-protective effects Increased risk of aspirin-induced gastric mucosal erosion in elderly Chinese men harboring SLCO1B1*1b/*1b while using aspirin and an ACEI or ARB concomitantly Adjunctive treatments for the prevention of chemotherapy- and radiotherapy-induced mucositis Telmisartan modulates the oral mucositis induced by 5-fluorouracil in hamsters Olmesartan decreased levels of IL-1beta and TNF-alpha RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model Protective effect of cashew gum (Anacardium occidentale L.) on 5-fluorouracil-induced intestinal mucositis Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive 5-Fluorouracil induces enteric neuron death and glial activation during intestinal mucositis via a S100B-RAGE-NFkappaB-dependent pathway Mucosal injury during anti-cancer treatment: From pathobiology to bedside Effects of antihypertensive agents on intestinal contractility in the spontaneously hypertensive rat: Angiotensin receptor system downregulation by losartan The role of angiotensin II type 1a receptor on intestinal epithelial cells following small bowel resection in a mouse model The renin-angiotensin system and the gastrointestinal mucosa angiotensin-(1–7) and Mas receptor axis in inflammation and fibrosis ACE2 and angiotensin-(1–7) axis in kidney and cardiac inflammation and fibrosis AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohn’s disease Activation of the renin–angiotensin system promotes colitis development Anti-inflammatory action of angiotensin 1–7 in experimental colitis Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury Effect of losartan (angiotensin II antagonist) on haematological and biochemical parameters in male Wistar rats Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis Losartan attenuates the coronary perivasculitis through its local and systemic anti-inflammatory properties in a murine model of Kawasaki disease Effects of single and combined losartan and tempol treatments on oxidative stress kidney structure and function in spontaneously hypertensive rats with early course of proteinuric nephropathy Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in cardiovascular diseases: Progress and challenges Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats TWEAK/Fn14 pathway: A nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: Focus on inflammatory bowel diseases TWEAK/Fn14 is overexpressed in Crohn’s disease and mediates experimental ileitis by regulating critical innate and adaptive immune pathways Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation The alpha-lipoic acid improves survival and prevents irinotecan-induced inflammation and intestinal dysmotility in mice Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice MMP-9 and RANKL/RANK in an experimental periodontitis model Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model and nonprotein sulfhydryl groups in tissue with Ellman’s reagent Effects of age and caloric restriction on glutathione redox state in mice An improvement of the 2(−delta delta CT) method for quantitative real-time polymerase chain reaction data analysis Download references We would like to thank to Neida da Mata, Flávio Maurílio dos Santos Lima, Cesar Augusto Trevisan Bordignon and Ramon Tadeu Galvão Alves Rodrigues for excellent technical support, and collaborators the Department of Morphology (UFC, Fortaleza, CE, Brazil). The graphic abstract presented in Fig. 7 was created with BioRender.com This work was financed by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (CAPES)—Finance Code 001 has Research Productivity Scholarship—PQ2 CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) Post Graduate Program Biotechnology-RENORBIO Federal University of Rio Grande do Norte (UFRN) Post Graduate Program in Pharmaceutical Science Junior Postdoctoral Student CNPq-Federal University of Rio Grande do Norte (UFRN) Polyana Crislayne Moreira de Sales Mota & Vitória Barros Marques Post Graduate Program in Biology Teaching in National Network-PROFBIO State University of Rio Grande do Norte (UERN) Post Graduate Program Morphofunctional Sciences Post Graduate Program Biochemistry and Molecular Biology Post Graduate Program Pharmaceutical Science Caroline Addison Carvalho Xavier de Medeiros C.A.C.X.d.M.; Writing-original draft preparation: M.M.B.O. C.A.C.X.d.M.; Writing-review and editing: M.M.B.O. C.A.C.X.d.M.; Project administration: C.A.C.X.d.M.; Funding acquisition: A.A.d.A. All authors have read and agreed to the published version of the manuscript The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-021-01969-x Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Probiotics and Antimicrobial Proteins (2024) Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research Six-year-old Satono Reve made the breakthrough in Grade 1 company at Chukyo on Sunday morning to become his sire Lord Kanaloa's 12th individual top-level winner He raced on the inside of midfield under 'the Magic Man' Joao Moreira and made ground to hit the front at the final furlong keeping on well to win the JRA's spring season sprint championship by three quarters of a length from the favourite Namura Clair It was the third successive runner-up finish in the race for the six-year-old Mikki Isle mare who was a length-and-a-quarter ahead of Mama Cocha in third Satono Reve was bred by Shirai Stud Farm out of the Sakura Bakushin O's winning mare Ciliege and sold for ¥58,320,000 (£3,002,467/€3,758,764) at the 2019 JRHA Select Foal Sale to the Satomi Horse Company He is the first Grade 1 winner out Ciliege She also has a four-year-old colt by California Chrome and a two-year-old son of Thunder Snow Ciliege is the dam of Grade 2 and Grade 3 winner Hakusan Moon who was twice placed behind Lord Kanaloa including in the 2013 running of the Takamatsunomiya Kinen The son of Admire Moon was her first foal and found a place at stud She is also the dam of Group 3 Bavarian Classic winner Warring States who was trained by Andreas Wohler for Qatar Racing and the son of Victoire Pisa was sold by Jamie Railton for €90,000 at the 2017 Arqana Arc Sale This is the eighth win from 12 starts for Satono Reve who was a dual Grade 3-winning sprinter last year and finished third to Ya King Rising in the Group 1 Hong Kong  Sprint in December for owner Hajime Satomi trainer Noriyuki Hori and breeder Shirai Bokujo The 17-year-old Lord Kanaloa was Japan's horse of the year and champion sprinter but has sired international stars over a variety of distances including the Dubai Turf winners Almond Eye and Panthalassa and the Australian-bred Blue Diamond Stakes winner and sire Tagaloa Satono Reve is the third winner of the Takamatsunomiya Kinen sired by the Shadai stallion and the second bred on the Lord Kanaloa – Sakura Bakushin O cross after First Force who defeated Namura Clair in the 2023 running Brazilian jockey Joao Moreira renewed his partnership with Satono Reve and has obtained a JRA short-term license allowing him to ride in Japan from this week until April 28 He will be paired with Stellenbosch in the Osaka Hai (April 5 Moreira won three consecutive graded stakes in same season last year including the Grade 1 Oka Sho with Stellenbosch and rode two winners at Nakayama on Saturday as his first day of the term He rode Satono Reve three times in Listed races last year and was on board again at Sha Tin Moreira said of Satono Reve: "He is a highly capable horse that has achieved success in stakes races and he also ran a great race in Hong Kong so I had always thought that he would win a Grade 1 race someday I was lucky enough to be able to ride him at this time and I am happy that he was able to win a Grade 1 race and the connections did not give me any specific instructions about the race I was able to get off to a good start and get into a good position but the wind was strong and there was a headwind in the straight so I created a wall in front of him until halfway through the race to avoid being affected by the headwind and once I had some space at the 250m left I was able to race according to plan." Enter Sandman: $1.2m Tapit colt wins Grade 1 Arkansas Derby and is Kentucky Derby bound  Million dollar Into Mischief colt claims Grade 1 Florida Derby with Kentucky in his sights  Published on 30 March 2025inInternational Copyright © 2025 Spotlight Sports Group Limited or its licensors Guineas contender Field Of Gold (Kieran Shoemark) after winning the Craven Stakes Photo: Dan Abraham / focusonracing.comNew 2,000 Guineas favourite Joao ‘Magic Man’ Moreira booked for Japanese contender Horse of the Year pensioned from stud duties – all this and more in our weekly digest of recent international racing news GB: Field Of Gold is the new 11-4 favourite for the Betfred 2,000 Guineas on May 3 after an impressive victory in the bet365 Craven Stakes at Newmarket on Wednesday [April 16] The son of Kingman was in a different league to his rivals in the traditional G3 trial over the full Classic mile trip in which he was brought between horses before extending away for an emphatic 3½-length victory “I’ve not been as excited about a colt winning a trial in a long time,” said co-trainer Thady Gosden whose father John has never won the 2,000 Guineas Owners Juddmonte now have an embarrassment of riches for the colts’ Classic, with Greenham Stakes winner Jonquil and promising Cosmic Year also possibles. More here • German Derby winner Palladium joins Gosden team More here USA: Kentucky Derby news this week is headed by the booking of Joao ‘Magic Man’ Moreira (right) for leading Japanese contender Luxor Cafe. The Brazilian was in Classic-winning form at the weekend when he partnered Embroidery to win the Oka Sho (Japanese 1,000 Guineas) at Hanshin How they qualified: watch all the videos as Derby field shapes up In other developments, Tampa Bay Derby winner Owen Almighty is back in the mix, having originally been ruled out in favour of the Pat Day Mile. Javier Castellano, who scored on Mage, has been booked, while Manny Franco will partner East Avenue. More here California Burrito has been added to the also-eligible list but River Thames will bypass Churchill Downs to concentrate on the Preakness. More here The Pimlico Classic is also the target for Gosger, who won the G3 Lexington Stakes at Keeneland on Saturday [April 12], plus UAE Derby runner-up Heart Of Honor, trained in the UK by Jamie Osborne. More here has been pensioned from stud duties at the age of 26 and will spend the rest of his life on the farm at Lane’s End Indy became a US champion as a four-year-old after being transferred from the UK to Neil Howard for whom he won a series of graded stakes including four G1s – the Pimlico Special Injured after the Jockey Club, he was retired to Lane’s End, where he spent his entire stallion career until his retirement at the end of the 2025 breeding season. His progeny include eight G1 winners headed by Saudi Cup winner Senor Buscador. More here UAE: Three-time British champion jockey Silvestre de Sousa has added the UAE jockeys’ title to his laurels The much-travelled Brazilian rider secured his first championship in the region when he ended the UAE season with 54 winners seven more than 12-time champion Tadhg O’Shea De Sousa, 44, secured the title mainly via a fruitful association with champion trainer Musabbeh Al Mheiri and Yas Racing, who won the owners’ title. More here He will ride as de facto first jockey to Roger Varian’s stable in Britain this summer. More here USA: Trevor McCarthy has announced his retirement at the age of 30 The jockey’s name has been notable only for its absence on racecards since he last appeared at Colonial Downs in August 2024 McCarthy revealed that he has quit the saddle and moved into real estate – for mental health reasons “I had just been so unhappy for so long and was a miserable person to be around,” he told TDN. “That’s why I took the steps to retire. I don’t want to go back to being that person. Riding was bringing out the worst in me.” More here GB: Records were broken all over the place at the two-day Tattersalls Craven Breeze Up Sale in Newmarket this week [April 15-16] with new marks established for highest price Wednesday’s second and final session was headed by the 1.750,000 guineas sale of a two-year-old colt by Havana Grey, knocked down to Alex Elliott for Amo Racing – and thereby eclipsing a new record set only 24 hours earlier when Anthony Stroud went to 1,400,000 guineas on behalf of Godolphin for an Acclamation colt The sale’s turnover of 18,804,000 guineas was an increase of 29% on last year’s sale, with the average and median up 25% and 15% respectively and 27 lots selling for 200,000gns or above. More here USA: Santa Anita to host Olympic equestrian events in 2028 More here USA: Judge dismisses ‘Shoegate’ lawsuit More here France: Death of former trainer Philippe Demercastel, aged 73 More here Japan: Unbeaten Croix Du Nord heads Satsuki Sho (2,000 Guineas) More here Hong Kong: Triple G1 winner California Spangle retired More here Australia: Retirement of Coolmore sprinter Switzerland More here GB: EBF announce £2 million support for racing in 2025 More here • Read previous editions of Seven Days In Racing View the latest TRC Global Rankings for horses / jockeys / trainers / sires Verry Elleegant: Melbourne Cup winner set to run in Prix de Royallieu after missing cut for Prix de l'Arc de Triomphe Photo: Photo: NZ Racing News/Bruno CannatelliVerry Elleegant Keeneland and King Charles III feature in our weekly digest of recent international racing news France: Melbourne Cup winner Verry Elleegant was forced to miss out on a long planned crack at the €5 million ($4.8m) Qatar Prix de l’Arc de Triomphe on Sunday [Oct 2] after it emerged she was unlikely to make the cut To the fury of trainer Francis Graffard and the mare’s owners many of whom were already on flights to Paris from Australia and New Zealand plans to supplement the 11-time G1-winning mare had to be abandoned when it became clear she was not among the highest-rated 20 horses in an oversubscribed field following a reassessment by the France Galop handicapper Very Elleegant was declared to run instead in the G1 Qatar Prix de Royallieu at ParisLongchamp on Saturday [Oct 1] with Australian jockey Mark Zahra taking the ride Prix de Diane runner-up La Parisienne also missed out as the Arc drew a maximum field of 20 for only the second time this century the field headed by Irish Champion Stakes winner Luxembourg.and defending champion Torquator Tasso Prix de l’Arc de Triomphe betting (Ladbrokes): 7-2 Luxembourg New Zealand: Leading rider Sam Weatherley has been suspended for nine weeks for his role in the race fall that resulted in the death of Japanese jockey Taiki Yanagida in August A committee of the Racing Integrity Board declared: “The reckless riding by Mr Weatherley initiated a series of events that ultimately led to the fall who was 28 and been riding in New Zealand for five years six days after suffering serious head and spinal injuries in a race fall at Cambridge USA: Keeneland’s September Yearling Sale ended a record run with gross sales of $405,495,700 and September Sale records for average ($142,429) and median ($70,000) prices A total of 2,847 yearlings were sold during the 12-day auction [Sept 12-24] Top lot was a $2.5m yearling colt by Quality Road a figure eclipsed in Ireland this week when a yearling sister to Prix Morny and Middle Park Stakes winner Blackbeard was knocked down to agents Jacob West and Richard Knight for €2.6m ($2.52m) on the opening day of the Goffs Orby Sale the highest price paid for a yearling in the world this year Australia: Chalk Stream will attempt to provide King Charles III with his first top-level victory since becoming monarch when contesting the G1 Metropolitan at Royal Randwick on Saturday [Oct 1] runs two days after Educator was due to become the first horse to run in the king’s name Hong Kong: Joao Moreira will miss a significant period of the season after he disclosed he faced three months out of the saddle while he deals with a painful hip injury the result of a labral tear. He will undergo platelet-rich-plasma (PRP) treatment which requires an extended period of rest South Africa: The National Horseracing Authority has taken the unusual step of releasing a statement to try to clear up rumours there was more behind champion trainer Paul Peter’s sudden decision to hand in his licence the regulator revealed it had been inundated with claims that many of Peter’s horses had tested positive for banned substances The NHA said the allegations were “unfounded and entirely baseless” with all tests taken from his runners between July and September 10 having returned negative results France: France: Mishriff to stand at stud in France in 2023 More here USA: Life Is Good faces four in Woodward More here USA: Dubai World Cup winner Country Grammer tackles Awesome Again More here Australia: Top weight Spanish Mission out of Melbourne Cup More here GB: BHA pauses jockeys saliva testing after Levey case More here GB: James Doyle facing longer absence due to Bennett's fracture More here GB: Jockey John Egan banned 10 days for abusing Hayley Turner More here • View all previous editions of Seven Days In Racing Real estate transactions in Routt County surpassed $31.1 million across 28 sales for the week of July 7-13 WaldronBuyer: Misty Dawn Curtin-Sellden and Lanc Martin SelldenDate: July 7Price: $375,000Property Description: 1,314-square-foot single-family residence on 0.15 acres of land 57940 Longfellow WaySeller: Michelle Olsgard and Nathan Lord StewartBuyer: Simon Richard FryerDate: July 10 2023Price: $675,000Property Description: 1,248-square-foot single-family residence on 0.66 acres of land 2305 Storm Meadows DriveSeller: Renka Rental LLCBuyer: Lacey WoodDate: July 10 2023Price: $699,975Property Description: 558-square-foot Oak CreekSeller: Natalie Harris Storie Revocable rustBuyer: Sunshine O 2023Price: $2,000,000Property Description: 5,605-square-foot 895 Conifer CircleSeller: Christine and William R McKelvieBuyer: Emily and Jordan OstermanDate: July 10Price: $1,783,000Property Description: 3,412-square-foot single-family residence on 0.32 acres of land 2215 Storm Meadows DriveSeller: Craig and Gwen WebsterBuyer: 590 Storm Meadows LLCDate: July 10 2023Price: $1,550,000Property Description: 1,789-square-foot GriepentrogBuyer: Gmeiner Family TrustDate: July 10 2023Price: $2,417,000Property Description: 2,927-square-foot single-family residence on 0.29 acres of land ArcherBuyer: Alyssa and Kevin CorrealeDate: July 11 2023Price: $1,050,000Property Description: 1,809-square-foot single-family residence on 0.24 acres of land 2023Price: $535,000Property Description: 920-square-foot 38795 Ridge Line CourtSeller: Austin HildeBuyer: Kelsey Leffel and Eric SpahrDate: July 11 2023Price: $144,000Property Description: 5.0 acres of agricultural land 2250 Apres Ski WaySeller: Bryan and Katherine MartinBuyer: Elisabeth and J 2023Price: $4,700,000Property Description: 2,420-square-foot Unit R-418 at OSP Condominium at Apres Ski Way No addressSeller: TDP Holdings LLCBuyer: Gabriel RichardsonDate: July 11 2023Price: $7,997Property Description: 0.77 acres of vacant residential land SullivanBuer: Flat Top Circle LLCDate: July 12 2023Price: $1,880,500Property Description: 2,641-square-foot Lot 37 at Eagleridge Townhomes Buildings 1,13,14 No addressSeller: Sage Creek Holdings LLCBuyer: Caleb DolifDate: July 12 2023Price: $218,600Property Description: SEC 28-6-87 Carlson-BoyntonBuyer: SBS Investments LLCDate: July 12 2023Price: $2,025,000Property Description: 2,100-square-foot single-family residence on 0.08 acres of land Lot B at Natches Way Townhomes at Fairway Meadows 29050 Yowell LaneSeller: PDL One LLCBuyer: Domingo and Margaret MoreiraDate: July 12 2023Price: $1,050,000Property Description: 37.89 acres of agricultural land Lot 25 at Lake Catamount Subdivision Exemption 29175 Buffalo TrailSeller: Domingo and Margaret MoreiraBuyer: PDL One LLCDate: July 12 2023Price: $1,050,000Property Description: 50.38 acres of agricultural land No addressSeller: Tri State Generation and Transmission Association Inc.Buyer: Catherine CantwayDate: July 12 2023Price: $300,000Property Description: 2.29 acres of vacant land 2015 Walton Creek RoadSeller: David & Dorothy Kagan Living TrustBuyer: 2015 Walton Creek #114 LLCDate: July 13 2023Price: $769,500Property Description: 938-square-foot Oak CreekSeller: Silverado Ranch LLCBuyer: Nathan and Stephanie YarbroughDate: July 13 2023Price: $1,620,000Property Description: 1,728-square-foot two-bath residence on 42.75 acres of agricultural land GrannisBuyer: Ashton and Haylee GriffinDate: July 13 2023Price: $1,240,000Property Description: 1,688-square-foot 2874 Owl Hoot TrailSeller: CP Ventures LLCBuyer: SBTCO ATX LLCDate: July 13 2023Price: $1,444,650Property Description: 1,896-square-foot 2000 Sunlight DriveSeller: Steamboat Sunlight Holdings LLCBuyer: Robert W 2023Price: $2,250,000Property Description: 2,696-square-foot single-family residence on 0.298 acres of land 3350 Columbine DriveSeller: Andrew MarshallBuyer: Christopher Marshall LairdDate: July 13 2023Price: $750,000Property Description: 1,060-square-foot Unit 503 at Sunray Meadows Condominiums Phase VII 38625 Hidden Springs DriveSeller: Linda MooreBuyer: Frederick L 2023Price: $135,000Property Description: 5.0 acres of agricultural land 2300 Mount Werner CircleSeller: Jim and Debbie Bates TrustBuyer: Kelly UngermanDate: July 10 2023Price: $90,000Property Description: 1/4-interest in and to Unit 455 at Steamboat Grand Resort Hotel Condominium 2023Price: $240,000Property Description: Interest in and to Unit 111 at Christie Condominiums Phase II 2300 Mount Werner CircleSeller: Casa Buena LLCBuyer: Lara FellinDate: July 13 2023Price: $114,000Property Description: Interest in and to Unit 507 at Steamboat Grand Resort Hotel Condominium Readers around Steamboat and Routt County make the Steamboat Pilot & Today’s work possible Your financial contribution supports our efforts to deliver quality your support is critical to help us keep our community informed about the evolving coronavirus pandemic and the impact it is having locally Each donation will be used exclusively for the development and creation of increased news coverage Real estate transactions in Routt County totaled more than $28.7 million across 13 sales for the week of March 15-21 360 Fox Springs CircleSeller: Freecke Investments LLCBuyer: Alexander McGraw and Julia Sobek MaricichDate: March 15Price: $805,000Property Description: 912-square-foot WattsDate: March 15Price: $41,500Property Description: 0.44 acres of vacant land 29050 Yowell LaneSeller: Domingo and Margaret MoreiraBuyer: Kevin and Rebecca KerstingDate: March 18Price: $1,450,000Property Description: 37.89 acres of agricultural land 37695 Routt County Road 179Seller: Ellen L BrockerDate: March 18Price: $815,000Property Description: 2,656-square-foot single-family residence on 8.58 acres of land Lot 11 at Saddle Mountain Ranchettes Subdivision 38620 Hidden Springs DriveSeller: Jacquelyn Cramer IRABuyer: JLJ Custom Homes LLCDate: March 18Price: $139,900Property Description: 5.0 acres of agricultural land 39315 Meadow Creek DriveSeller: Brian and Virginia LivermanBuyer: SBS KMCL LLCDate: March 18Price: $12,000,000Property Description: 7,046-square-foot single-family residence on 5.0 acres of land 114 Hillside DriveSeller: James Jay and Linda Joy ZafaranaBuyer: Angela Jane and Nicholas Andrew KennedyDate: March 19Price: $2,700,000Property Description: 3,474-square-foot single-family residence on 0.72 acres of land Address: 1945 Cornice RoadSeller: Hot Cakes LLC Ritota and Ritota PABuyer: Craig and Paula HalstedDate: March 19Price: $685,000Property Description: 771-square-foot 37998 Saddle Mountain CircleSeller: David M CorrealeDate: March 19Price: $1,169,000Property Description: 2,080-square-foot single-family residence on 5.61 acres of land YampaSeller: Deherrera Family TrustBuyer: Rachel HeltzelDate: March 20Price: $430,000Property Description: 1,163-square-foot single-family residence on 0.22 acres of land HillDate: March 20Price: $510,000Property Description: 35.0 acres of agricultural land 26780 Willow Gulch Drive and 26865 Linda Kay PlaceSeller: Kevin H and Melenie SnyderBuyer: Dayshia Lee Koroulis and Derek Anthony SwitzkyDate: March 21Price: $80,000Property Description: 0.80 acres of vacant land Lots 118-119 at Steamboat Lake Subdivision 2 LerachBuyer: Clint TassetDate: March 21Price: $7,900,000Property Description: 4,239-square-foot Unit R-711 at OSP Condominium at Apres Ski Way Correction: The 2016 sale of 440 Garden Avenue in Mount Vernon was approved in 2013 Information about the approvals was incorrect when this article originally appeared Aug The Mount Vernon home where Robert Espada grew up was intended to be his inheritance The house that Marlon Young bought last year in Mount Vernon was supposed to be a ticket out of Queens for him Only one of these stories will have a happy ending That’s because the address in each narrative is 440 Garden Ave. a modest two-story home across from Memorial Field that is at the center of a court fight over who really owns it Both sides have claims against the City of Mount Vernon allege that the city improperly foreclosed on his late grandmother’s home in 2012 The Youngs claim their deed is the only valid one and that Comptroller Deborah Reynolds was wrong last year to reject it "Mount Vernon has disappeared with people's inheritance," Cynthia Espada said last week who would die only five months later. Nellie had not left a will and Robert didn't go to surrogate court to transfer ownership claims he continued paying taxes on the house But the city began foreclosure proceedings in 2011,a when nearly $14,000 was owed in back taxes Espada claims he never received notification that the city was threatening foreclosure A March 2012 court order cleared the way for the city to take ownership of the house as a creditor, could not take the property of a dead person without petitioning Surrogate Court to appoint an administrator to represent Nellie Espada's interests It is unclear whether city officials knew Nellie Espada had died although the Espadas insist her death certificate was filed with the city The house was included in a 2013 auction of city-owned properties did not bid but told the finance department he was interested in the property.  the city sold the property to Moreira for $51,000 giving him a deed signed by then-Mayor Richard Thomas Espada claims he didn't even know that the city had owned it – finding out only when his stuff was removed by Moreira while he was in Georgia from February to April that year "I'd been in that house my entire life and my grandparents told me I was going to pass it on to my daughter after me." Moreira was adamant that Espada was aware he was losing the house saying he had conversations with him several times before buying the property. He said Espada never made any effort to pay the back taxes to recover the property from the city Moreira said he gave Espada more than 60 days to vacate the house at which point Moreira removed whatever belongings Espada left behind The Espadas claim Moreira was required to seek court action to remove him suggests he was worried the city marshal would have discovered there was something wrong with the title transfer The Youngs move inThe sale to Moreira came just five weeks before the city was going to auction off more than a dozen foreclosed properties The list approved by the City Council had 440 Garden Ave. removed from it because the sale had already happened Sales of city property in Mount Vernon require the approval of both the City Council and the Board of Estimate and Contract The Garden Avenue home was on the 2013 auction list and both bodies that year approved the sale to Moreira although the sale was not completed until three years later who in the early 2000s was a night distribution manager for The Journal News a Mount Vernon native who he married last year took it upon herself to research what Mount Vernon had done She said her husband never should have paid any taxes on the property once his grandmother died And convinced that the city couldn’t take the property of a dead woman with no will the Espadas  went to Westchester Surrogate Court in May 2019 detailing what she alleged was the city’s fraud and giving him 30 days to vacate the house he had spent $100,000 to $150,000 to renovate the house in anticipation of selling it He said he was not concerned about Espada's letter and believed the city had gotten the house properly and so had he Moreira sold the house to Young and his father The following month Robert Espada was named the administrator of his grandmother's estate and obtained a deed showing he transferred the property to himself and his wife the Youngs’ deed has not been recorded by Westchester County — but Robert Espada’s deed has the city comptroller, would not sign off on the title transfer to Young She agreed with the Espadas that her predecessor had improperly obtained the property in 2012.  Marlon Young said he was shocked to learn someone else had a claim to the house “I did everything I was supposed to,” he said Walker said she did not remember details of the 440 Garden Avenue sale She said property owners would be sent several notifications that their homes were subject to foreclosure and that it was the law department's responsibility to make sure the right people were notified.  Corporation Counsel Brian Johnson had no comment as the matter was being reviewed and was the subject of pending litigation.   the Espadas began eviction proceedings in Mount Vernon City Court to force the Youngs out of the house though that was quickly dismissed when they didn't pay a $400 filing fee or apply to have fees waived The Youngs then sued the Espadas and Reynolds in state Supreme Court Among the court exhibits was a letter from the title insurance company detailing Reynolds' refusal to approve the Youngs' deed That mirrored a criticism of the comptroller levied this spring by the head of the New York State Land Title Association who said members were no longer providing title insurance in Mount Vernon because Reynolds was taking too long to process the paperwork Reynolds responded that paperwork was often submitted with incomplete or erroneous information Cynthia Espada knows all about the attacks on Reynolds since she took office in 2018 — including that she doesn’t pay bills and keeps other officials in the dark about city finances But Espada insists Reynolds is the only official willing to look into what she considers the city's fraudulent takeover of her husband's home The Espadas have answered the Youngs' lawsuit with their own counterclaims against the city Joseph Altman, to seek a default judgement ordering Reynolds to accept the Youngs' deed and blocking any effort to remove the Youngs from the house.  Altman argued that the Espadas have no legal claim to the property and that the transfer of ownership from the city to the Moreiras to the Youngs was valid And even if the city erred in taking ownership the Espadas allowed too much time to pass before making any claim He said there was no reason for the title search company to go beyond the chain of title "The documentary evidence firmly establishes that the (Youngs) are the proper legal owners of the property," Altman wrote While the two families are in a legal battle the Espadas also think of the Youngs as victims in the case “The Youngs are now in the unenviable position of losing a real property for which they allegedly paid good money,” the Espadas’ lawyer wrote in court papers last month seeking a court judgement validating his clients’ claim to the property Twitter: @jonbandler Distribute Your News Directly to Readers and Internet Search Widespread Integration into Global News Publications Industry Specific to Reporters and Trade Publications Delivered Over News Wires Geographic & Topic Specific � CEVA Logistics in Italy renews its partnership with Magneti Marelli Parts & Services for six years managing spare parts storage and distribution at its 30,000 m� logistics hub in San Pietro Mosezzo (Novara) and peripheral warehouses in Pero and Padova Environmental Protection Agency (EPA) Administrator Lee Zeldin traveled to Huger roundtable hosted by the South Carolina Manufacturers Alliance spoke at the Job Creators Network �Freedom Fighters� Summit in Savannah A global report published by the World Health Organization (WHO) highlights that the underlying causes of ill health often stem from factors beyond the health sector For its sustainable refrigerated transport business Tevex Logistics GmbH is adding two new Schmitz Cargobull refrigerated vehicles to its fleet: an all-electric S.KOe COOL box body semi-trailer and an S.KO COOL box body semi-trailer equipped with an S.CU d80 ePTO ready cooling unit Lenovo UK & Ireland is proud to announce that it has been awarded the prestigious Menopause Friendly Accreditation recognising its commitment to supporting employees experiencing menopause in the workplace issued a new report today that highlighted a significant rate growth employed by law firms while demand was up only 0.5% and productivity slipped 2.4% Royal Bank of�Canada�(TSX: RY) (NYSE: RY) will release its second quarter results for 2025 on�May 29 which will be made available at� rbc.com/investorrelations � Borealis launches renewables-based ethylene vinyl acetate (EVA) solution developed specifically for footwear midsole applications � The new grade is part of Borealis� Bornewables� portfolio of premium solutions made from renewable feedstocks delivering virgin-quality performance while reducing reliance on fossil-based materials � The innovation is another example of … � Metpack�s Ezycompost paper is coated with BASF�s biopolymer ecovio� �70 PS14H6 � Excellent processability with faster coating speed than polylactic acid (PLA) � Food-contact approved with outstanding barrier properties � Home-compostable solution extends end-of-life options for paper packaging and supports organics recycling For sustainable food … Enhanced connectivity in agriculture is predicted to add more than $500 billion to global gross domestic product by the end of the decade but I feel like I did a bunch of cartwheels during the whole year and kept jumping into what was working." at her Fisherman's Wharf store right before her episode of Shark Tank was set to air in Spring 2019 WATCH: Bay Area entrepreneur with a sweet story goes from sobriety to the 'Shark Tank' To say things have changed for the business since is definitely an understatement "It's like a big whirlwind," Moreira says but I feel like I did a bunch of cartwheels during the whole year and kept jumping into what was working." Moreira's journey to becoming a business owner happened in 2015 when she decided to get sober The entrepreneur's love of cookie dough helped her in her battle with alcoholism and she encourages others to have a conversation surrounding this taboo issue "I launched Doughp For Hope with the company to raise more awareness about mental health and addiction," Moreira told ABC7 in 2019 "We also have mental health certification for all of our staff." RELATED: San Francisco launches street crisis team to respond to 911 mental health, addiction calls Since then, the dessert company has donated more than $20,000 to organizations that promote the cause of mental health. 1% of profits currently go toward the non-profit She Recovers which serves more than 325,000 women in need of help with recovery and substance abuse It was an emotional cliff dive," says Moreira who is grateful that portion didn't make the final cut of her episode RELATED: Find local resources to help with complicated issues Several months after her television appearance an investor reached out and helped her open a new store in Las Vegas But just as DOUGHP was beginning to really take off Moreira and her new husband made the tough decision to shutter all of Doughp's brick-and-mortar stores "It's kind of like sobriety," the business owner says "Every day I choose to stay on this path in recovery every day I try to make the best choices I can for me and the company." Moreira and Doughp started shifting to more e-commerce at the end of 2019 Moving to Las Vegas also cut the business's operating costs RELATED: Las Vegas looks to attract Bay Area tech workers with lack of state income tax, more affordable housing "They say it's an automatic raise when you move to Las Vegas because there's no income tax," Moreira explains DOUGHP has been reaching more customers than ever "At the time we were shipping around 30 boxes a month in November," Moreira says The growth was incredible we did 50K online in 2019 and we did 2.5 million online in 2020!" When asked if more people are seeking that comfort food during the pandemic the businesswoman replied in absolute agreement "Cookie dough is a bite of nostalgia you take a bite and you're taken back to a world of kinder softer memories nostalgia and happier times," Moreira says that she's on her way to "World Cookie Dough Domination." With her projected $5,000,000 in sales for 2021 By: Greg Hrinya Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced except with the prior written permission of Rodman Media Business 20080805 BSN HOME SALES 1125 A home at 91-983 Papapuhi Place in Ewa Beach that is for sale The house next door at 91-981 Papapuhi Place recently sold Already a Honolulu Star-Advertiser subscriber? Log in now to continue reading Coldwell Banker Realty has announced several new independent agents joining the firm in its Kapolei office: Filipiak previously served as a Realtor-associate at Compass >> Martha Moreira most recently served as a paralegal for a real estate attorney in Honolulu She earned a bachelor’s degree in history from Georgetown University in 2017 and a graduate certificate in paralegal studies from George Washington University in 2019 >> Kiana Pamatigan is also a flight attendant with Hawaiian Airlines >> Lisa Onishi previously served as a Realtor-associate at Locations LLC She has nearly two decades of real estate experience >> Cara Willard most recently served as a Realtor-associate at Compass As a young man, Marcel Gautherot abandoned his architecture studies in Paris to travel the world as a photographer. He became best known for his documentation of the construction of Brazil’s new capital city, Brasília, which can be found in a collection of his work, The Monograph we’d like to thank you for joining the debate - we’re glad you’ve chosen to participate and we value your opinions and experiences Please choose your username under which you would like all your comments to show up Please keep your posts respectful and abide by the community guidelines - and if you spot a comment you think doesn’t adhere to the guidelines please use the ‘Report’ link next to it to let us know Please preview your comment below and click ‘post’ when you’re happy with it Physicists believe they're very close to finding Higgs boson It's a subatomic particle that would help explain what gives matter all over the universe its size and shape an element that makes steel more flexible and strong Niobium is used in a 10th of all the world's steel — in everything from cars to cameras and it was also used to make the magnets in the world's largest particle accelerator the $10 billion Large Hadron Collider in Switzerland Without the high-energy proton collisions the machine creates scientists would not have been able to come so close to Higgs boson Navy Admiral convinced Brazilian banker and diplomat Walther Moreira Salles to back his venture to produce niobium Moreira Salles bought a majority stake in the company From Bloomberg: That market dominance has helped make the mogul’s heirs Brazil’s richest family The brothers do not currently appear on any international wealth ranking “We created the whole market,” Tadeu Carneiro said in an interview at his office in Sao Paulo “Now you see how fantastic this company is -- its value these dividends -- but we started from zero when niobium was just a laboratory dream.” more than the Salles' $7.1 billion interest in Brazilian bank For the whole run down of the Salles' wealth, head to Bloomberg> Stellenbosch bloomed in Sunday's Oka Sho (Japanese 1,000 Guineas) to give her sire Epiphaneia a second win in the Hanshin Classic since 2020 Brazilian maestro Joao Moreira was in the plate aboard the Northern Farm homebred who had been off the track since being a narrow runner-up to Ascoli Piceno in the Hanshin Juvenile Fillies in mid-December and it was that same rival and race favourite who closed to within three-quarters of a length here The Sakae Kunieda-trained winner had been settled in mid-pack but was edged into space by his rider at the top of the straight and had too much power for her opposition the 2014 Japan Cup winner standing at Shadai Stallion Station claimed the Oka Show en route to landing the Japanese Fillies Triple Crown Stellenbosch is the first foal on the track from Blaukrans a three-time winner by Rulership out of Land's Edge a half-sister to the breed-shaping Deep Impact Kunieda added: "She has high ability and she's a good horse "Looking at the horse's body and her composure I don't think there will be any problems in the 2400m Oaks I went safely without any trouble and won the first race so I would like to dream of winning the next one and the one after that [the Triple Crown]." 'She’s got every attribute you could want' - Winx filly set to command world's attention at Inglis Easter Yearling Sale  Published on 7 April 2024inInternational Citizens Count Executive Director Anna Brown discusses civics education and legislation currently moving through the state house Legal settlement clears way for Portsmouth affordable housing plus a new neighborhood takes shape in Peterborough A committee tasked with reviewing concepts for housing development on Old North Main Street heard from Lakes Region Community Developers discussed the conceptual plan for the development of a 10-acre parcel A 12-unit raised commercial building was pitched in 2024 to replace the shack businesses but that idea was scrapped following public criticism The site will be cleared and equipped with utility service needed for the new units by the end of 2025 with construction scheduled to start in 2026 A developer plans to construct six buildings with a total of 36 housing units could soon see new life as an assisted-living and elderly housing facility The White House wants to eliminate federal support for public media Congress will vote soon on a proposal to slash millions from NHPR and NHPBS’ budgets Get a year’s worth of NH Business Review for the price of lunch Phone: +44 (0) 1858 438800 Email: [email protected] You are currently accessing Investment Week via your Enterprise account If you already have an account please use the link below to sign in If you have any problems with your access or would like to request an individual access account please contact our customer service team Join now Login © Incisive Business Media Limited, Published by Incisive Business Media Limited, New London House, 172 Drury Lane, London WC2B 5QR. Registered in England and Wales with company registration number 09178013. Part of Arc network, www.arc-network.com Pedro Moreira Salles is a Brazilian billionaire who has a net worth of $3.3 billion One of the four brothers who inherited a banking and mineral fortune Pedro Moreira Salles started to build his estimated net worth of $3.3 billion when he joined his late father's Unibanco in 1989 which is the largest private banking institution in Brazil today was headed by his father Walter Moreira Sales for several decades Salles gradually rose through the ranks in the bank In 1991 he landed the post of Vice President for and six years later he became the Chairman of the Board of Directors He was named CEO in 2004 and holds most of the responsibility for the 2008 merger of the bank with Banco Itau Pedro became one of the biggest individual shareholders of Itau Unibanco Holding SA with a 2% stake He made a comeback to billionaires' club this year thanks to his interests in Cia Brasileira de Metalurgia & Mineracao (CBMM) Pedro is one of the majority shareholders in CBMM with a 68.5% mutual share Pedro is also said to be a member of the Group of Fifty It's a nonprofit initiative that consists of Latin American executives and is sponsored by the Carnegie Endowment for International Peace and the Inter-American Dialogue in Washington © 2025 Celebrity Net Worth / All Rights Reserved While some people might confuse Doughp's name with one of Snow White's dwarves, the edible cookie dough brand has a tasty business idea that others might agree is "dope." Putting the play on words aside the millennial-focused company turned to "Shark Tank" to raise capital this sweet treat might have needed a little more time mixing in the bowl Some companies are created to fill a void, others rise from a particular passion, and a few combine both into a successful endeavor. With Doughp, founder Kelsey Moreira created a company that seeks to be "an indulgent dessert platform for mental health and addiction recovery," per the company's LinkedIn profile While some brands weave social issues into their mission statement Doughp's inception arose from personal experience As seen on the company website, Moreira turned to her "happy place" (aka the kitchen) when she chose to become sober. Through trial and error, her recipe featuring an "egg-sub" brought her sweet joy, and she set off on a dessert adventure. While many people turn to an easy edible cookie dough recipe Doughp is not afraid to speak openly and honestly about mental health A portion of company sales is donated to the SHE RECOVERS Foundation Even though one cookie dough scoop might not change the world Doughp wants to spark a conversation with every bite If you or someone you know needs help with mental health, please contact the Crisis Text Line by texting HOME to 741741, call the National Alliance on Mental Illness helpline at 1-800-950-NAMI (6264), or visit the National Institute of Mental Health website Appearing on Episode 25 of the tenth season of "Shark Tank," Doughp came on with a strong presentation and offer Founder Kelsey Moreira petitioned the sharks for $450,000 in exchange for a 10% stake While she pitched the idea as "nostalgia in a scoop" for the "big kid in all of us," the investors were not quite as sweet on the deal as she had hoped Mark Cuban was the most vocal about investing in an "unhealthy" food company in the episode stating "The conflict I have is the whole obesity thing and getting behind a product that's saying 'Eat more,'" Moreira believes that Doughp appeals to that moment of giving "yourself a little sweetness." Over the years, brands have found ways to transform raw cookie dough into a safer dessert that involve more than just removing the eggs Flour must also be pasteurized to remove potential E Since many people would rather eat than entertain a science experiment With a click of a mouse or a purchase at the store a pint (or two) of edible cookie dough can be in the fridge you don't even have to sneak a nibble when no one is looking while all the Sharks believed in Kelsey Moreira and her concept The Sharks were not hungry for the sweet treat but not landing a deal during Doughp's dip into the reality television pool did not prevent the company's success a phenomenon known as the "Shark Tank effect" inevitably helped the start-up flourish the treat has found its way to many cookie dough fans Doughp decided to pivot slightly from its original "Shark Tank" pitch the brand closed its storefronts and moved all products to an e-commerce shop This shift away from a brick-and-mortar model didn't spell the end for Kelsey Moreira's success by any means Thanks to the company's consistent social media presence and openness about addiction recovery and mental health Doughp's loyal following grew to an impressive audience of over 120,000 cookie dough lovers on Instagram alone People seem to love their branding and Moreira's backstory which both seem to align perfectly with its products — raw with just the right amount of sweetness As for 2023, Doughp is thriving, frequently releasing fun new flavors and staying on top of trends. Currently, Doughp offers 21 flavors, including classic chocolate chip, s'mores and a mystery flavor — all available in variety packs that can be purchased as bundle deals Many flavors are listed as either sold out or offered for a limited time which tells us this brand is in high demand and on top of its marketing Customers also have the option to gift a cookie dough subscription box of up to a year allowing the receiving party to enjoy two tubs per month In addition to Costco, the brand can be found at Walmart and other retailers Kelsey Morreira (now Kelsey Witherow) recently celebrated eight years of sobriety and is now happily married She is motivated by her success in the business world brought on by the overwhelming support Doughp fans have shown her since her "Shark Tank" debut Her inspiring story proves that even if a brilliant idea doesn't quite win over the Sharks in the tank it can become a smashing success with the right blend of motivation and execution If you or anyone you know needs help with addiction issues, help is available. Visit the Substance Abuse and Mental Health Services Administration website or contact SAMHSA's National Helpline at 1-800-662-HELP (4357).