A group of six faculty members from Alfred University’s Inamori School of Engineering attended last week’s Third São Carlos School on Glasses and Glass-Ceramics
which brought together 80 students and professors from around the world to advance glass science education and research
The School on Glasses and Glass-Ceramics featured a group of international professors and students from 12 countries
featured a carefully balanced program of high-level scientific lectures during the day
complemented by vibrant social activities in the evenings
Event sponsors included: the Center for Research
Technology and Education in Vitreous Materials (CeRTEV)
The New York State College of Ceramics at Alfred University
and the International Commission on Glass (ICG)
organizer of the São Carlos School on Glasses and Glass-Ceramics
and supports education and outreach efforts focused on glass and glass-ceramics
“Special recognition goes to the New York State College of Ceramics at Alfred University
whose exceptional contribution enriched our program significantly,” event organizers wrote after its conclusion on Saturday
“Their delegation of six distinguished faculty members delivered outstanding lectures that inspired intellectual engagement and genuine excitement among participants.”
Faculty from Alfred University attending the event (with lecture topics) were S.K
Inamori Professor of materials science and engineering
“Structure-terahertz property relationship in glasses”; Doris Möncke
non-silicate oxide glasses”; Collin Wilkinson
“Glass relaxation”; Rebecca Welch
visiting assistant professor of materials science and engineering
“Computational Modeling of Glasses: Statistical Mechanics Model of Glasses and Topological Constraint Theory”; Benjamin Moulton
“Spectroscopies (Structure of a variety of oxide glasses) and Ion-exchange in glasses”; and Caio Bragatto
assistant professor of ceramic engineering
“Electrical properties of glasses.”
The main objectives of the São Carlos Schools are to:
Instructors for the São Carlos School on Glasses and Glass-Ceramics are well-known experts in experimental
and computer simulation studies of glasses
The school had approximately 40 hours of classes
Focused on a professional education with an emphasis on APEX
our applied and experiential learning program
Alfred University has a long history of educating socially conscious students who make a difference in their professions and their communities
Your gifts of time and financial support help transform student lives every day
Copyright © 2025 Alfred University
LATAM Airlines is boosting its in-house Boeing 787 MRO capacity following its recent order for 10 more of the aircraft Oct. 28
The airline has just invested 40 million Brazilian real (approximately $6.9 million) in a new hangar at its Sao Carlos MRO base that will enable it to perform 787 maintenance in-house
LATAM’s 787 maintenance is currently performed outside of Brazil. Earlier this year, it signed an agreement with Amman, Jordan-based Joramco for 787 C checks. However, the carrier has been working to increase its in-house maintenance capabilities ahead of its upcoming fleet growth
LATAM operates 37 787s and it expects to operate a total of 52 of the aircraft type by 2030
the new maintenance hangar is its largest MRO investment in the last decade
In addition to increasing capability for more in-house MRO services in Sao Carlos
provide greater flexibility and shorten turnaround times
the new hangar will be able to accommodate up to three Airbus A320s simultaneously
It will also be equipped to paint large aircraft
LATAM plans to carry over several advanced technologies already used at its Sao Carlos MRO base to the new hangar, including drone inspections and autonomous logistics carts. LATAM was the first Latin American airline to deploy Donecle drones
It says drone-based inspections have made the process 12 times more efficient
the new hangar will also result in the creation of 300 new jobs
Its Sao Carlos MRO site currently employs 2,000 people and handles more than 60% of LATAM group’s scheduled maintenance
The new hangar is expected to begin operations in September 2025
Lindsay Bjerregaard is managing editor for Aviation Week’s MRO portfolio
and product and service news for MRO Digest
insight and analysis from our award-winning editors delivered to your inbox daily
Metrics details
The correct choice of a stone aggregate for railway ballast is directly related to the stability
The aggregate must meet several criteria to ensure it is the most appropriate material
the present study aimed to evaluate four distinct stones: two granites
all mined in the eastern region of the state of São Paulo
Using Brazilian and ASTM procedures for stone samples
the tests were conducted on 55 and 75-mm specimens
all stones met the physical properties established by the standards
with all stones where the tested materials advantageously exceeding the 100 MPa required by the Brazilian standard
Regarding the accelerated weathering test with ethylene glycol
only basalt showed more significant changes
although its resistance to weathering was still lower than 10%
Our findings indicate that these stones perform adequately as ballast for railway applications
The study is expected to contribute to revisions of technical standards and the improvement of a database on Brazilian stone materials for use as railway ballast
the present study aimed to determine the physical-mechanical and degradation characteristics of four different types of rocks: two granites
and assess their suitability for use as railway ballast
By analyzing properties such as compressive strength
the present study may support the selection of stones that meet the regulatory requirements for performance and cost-effectiveness
contributing to the optimization of relevant railway infrastructure projects for passenger transport in the eastern region of the state of São Paulo
the research not only expands the understanding of the properties of ballast materials but also suggests important practical recommendations for the construction and maintenance of railways
contributing to promoting greater safety and operational efficiency
The three geological units that make up the present study are highlighted in bold in the legend
LEFT: panoramic view of a mapped sector in a quarry with highly fractured basic intrusives (DIA)
RIGHT: sampling of coarse aggregate directly from the stockpiles of the quarry processing plant
Where σwet and σdry are the tensile strength of the material in wet and dry conditions, respectively.
To obtain information about the weathering of stones, two types of alterability tests were conducted: with sodium sulfate and with ethyleneglycol, all with oven drying. During these cycles, all samples were qualitative and quantitatively evaluated by measuring mass losses, visual examinations, and photographic records of any damages (fissures, cracks, flaking, oxidation, and disintegration) in the specimen.
and collection of test specimens for UCS tests with 2 diameters; (D) DIA sample (75 mm) submitted to the PLT
The results of the tests performed are presented following the order of the methodology used in the study
The information regarding the degrees of microcracking and stone alteration is discussed below, with the most important petrographic features analyzed at the microscopic level and a summary of the physical indices in Table 2; Fig. 4.
LEFT: Macroscopic appearance of natural stone cylindrical surfaces (Ø 75 mm); RIGHT: Photomicrographs (crossed nicols)
Observe twin crystals of Pl and in the details
GRAN2: clusters of Mu crystals in poikilitic texture
DIA and BAS: subophitic texture with Pl laths surrounded by subhedral crystals of Au/Pg and Op
Pl plagioclase and Fk potassic feldspar
basic stones present the most expressive values of this parameter
due to the higher percentage of ferromagnesian minerals in their composition
The materials studied are also within the maximum limits established for apparent porosity (η) and water absorption (α)
being 2% for apparent porosity and 1–2% for water absorption
It is worth highlighting the relatively lower values for DIA (compact rock) and the higher values for BAS (thinner stone
still within the limits established by the standard
In general, stones correspond to the lithological characteristics to which they are associated. They are massive stones, with few voids, as indicated by their apparent specific gravity and low water absorption. The detailed relationship between the mineralogical composition and the main physical properties can be seen in Fig. 5.
Relationships between mineralogical composition and physical indices from Ø55mm (LEFT) and Ø75mm (RIGHT) specimens
In terms of the strength of the intact stone, the results of the uniaxial compressive, point load, and rebound hammer tests are presented in Table 3; Fig. 6
taking into account the two diameters of the specimens tested in the present study
Diameter 55 mm (in black) e 75 mm (in red)
Test data in dry (LEFT) and saturated (RIGHT) conditions
Regarding the values of the hydraulic weakening coefficients (R)
all the stones tested presented a decrease in uniaxial compressive strength when analyzed in the wet condition
with reductions in strength between 4% and 18%
and reaching a slightly more pronounced value (27%) in BAS
and conditions of microcracking and mineral alteration
as in the case of the more accentuated decay of basalt
R coefficient values were slightly higher in the tests with 75 mm-diameter samples
obtaining cylindrical test specimens with a larger diameter is much more expensive
both due to the greater amount of representative stone blocks to be collected in the field
and due to the excessive wear of diamond drill bits
especially in more abrasive stones (quartz-rich)
such as granite and other similar materials
As for PLTs, the results were similar to those obtained from the RCU tests. Where, once again the DIA diabase stood out, with the highest point load strength index, Is(50), in both diameters used, as can be seen in Table 3; Fig. 6C,D
an unexpected result was found for granitic stones
where the Is(50) obtained in the wet condition was slightly higher than in the dry condition
this result can be justified by the material’s variability
as this type of variation is sensitive to the characteristics of the stones
it is a material with low porosity and water absorption
so somewhat similar results of both conditions are expected
Correlations between PLT and UCS tests in dry (LEFT) and wet (RIGHT) conditions
the values varied very little between the dry and wet conditions for the two diameters tested
This comparison suggests that the presence of water had little influence on the tests with the materials under study
which is consistent with the data previously shown
such as the physical indices (stones with porosity < 1.96% and water absorption < 0.68% (very low values)
as well as the hydraulic weakening calculated from the UCS tests
Correlations between SHR and UCS tests in dry (LEFT) and wet (RIGHT) conditions
The proposed equations for estimating stone parameters from the hammer rebound number can be valuable in the preliminary phase of a project
given that the test is easy to perform and non-destructive
the results and comparison with previous studies indicate that the equations should be used with caution and only for the specified type of stone
Using aggregate samples with different sizes
LAA Los Angeles abrasion test (Gradation F) and T-shock and SC crushing strength tests were performed to verify the mechanical strength of the aggregates
Comparison between mineralogical composition and LAA
Set of fragments before (ABOVE) and after (BELOW) the T shock strength tests
highlighting once again the performance of basic stones
which have a mineralogical composition consisting essentially of high-hardness minerals
its textural arrangement assented with types of minerals
and microcracking conditions of the minerals
provides more expressive mechanical strength
The accelerated weathering laboratory tests on each material were carried out taking into account three different crushed stone fractions: A (63.5 to 38 mm)
all stones performed well after 5 cycles of immersion in sodium sulfate or ethylene glycol solution followed by oven drying
either in terms of mass loss or any other change visible to the naked eye
Given that these stones have low water absorption and porosity indices
the penetration of the saline solution is difficult
preventing the breaking of bonds between particles due to the crystallization of sodium sulfate
Photographic records of BAS basalt fragments degraded by ethylene glycol: (A) Surface degradation (Cycle 1); (B) Cracks (Cycle 2); (C) Fissures (Cycle 3); (D) Spalling (Cycle 1)
In order to compare and discuss the capabilities and limitations of different stone materials for use as ballast
a careful selection of tests considered essential for technological characterization was carried out
The analysis was conducted through petrographic analysis and determination of physical
and alterability properties that will dictate the performance of the materials when used in railway works
The tests showed these are compact stones with low water absorption
correlated to the geological context in which they are inserted
and diabase (Serra Geral Formation) stood out for their high compressive strength
there was no significant difference between cylindrical samples of 55 mm and 75 mm in diameter
This comparison is relevant given the practical advantages associated with the smaller diameter
and less wear on equipment and diamond drills in laboratory demands
The long-term effects of the tropical climate and the use of aggregates without binders were simulated using accelerated weathering tests
showed good chemical and physical stability
the tested fractions of the respective basic stone showed resistance to weathering that was still lower than the maximum limit established by the Brazilian standard
the stones analyzed showed good performance for use as coarse aggregate for railway ballast
resistant stones with low water absorption
which tend to produce high-quality aggregates
although a large number of tests were performed with representative samples
the results must be considered valid only for the stones evaluated in this research
given the geotechnical variability of the properties of each material
although the Brazilian standard stipulates that at least five accelerated weathering cycles must be performed for laboratory tests
future research may expand this approach to include long-term performance assessments
encompassing different climates and environments
to provide a more comprehensive and practical understanding of rock durability in the railway context
this study is part of broader research that contributes to the development of a more comprehensive database on the properties of stones used as railway ballast in Brazil
serving as a reference for updating technical standards
in addition to supporting the selection of more suitable materials and increasing the efficiency and durability of railway infrastructures
All data generated or analysed during this study are included in this published article
Associação Brasileira dos Transportes Ferroviários (ANTF). Informações gerais - o setor ferroviário de carga brasileiro. Disponível em: https://www.antf.org.br/informacoes-gerais/
Laboratory characterization of fouled railroad ballast behavior
Castro, G. B. et al. L. Numerical and experimental study of the unsaturated hydraulic behavior of a railroad track profile considering fouled ballast subjected to tropical climate condition. Adv. Transport. Geotech. IV 467–482 https://doi.org/10.1007/978-3-030-77238-3_36 (2022)
Oliveira Filho, J. J. P., Costa, R., Bernucci, L. B., Motta, R. & Moura, E. Degradação do lastro ferroviário - principais aspectos e estudos de caso. Transportes 25, 21–34. https://doi.org/10.14295/transportes.v25i3.1340 (2017)
Selig, E. T. & Waters, J. M. Track Geotechnology and Substructure Management https://doi.org/10.1680/tgasm.20139 (Thomas Telford
Varuntanya, K. et al. Laboratory investigation of railway-used ballast morphology using 3D imaging data analyses. Case Stud. Const. Mat. https://doi.org/10.1016/j.cscm.2023.e02272 (2023)
Diógenes, D. F., Castelo Branco, V. T. F. & Motta, L. M. G. Avaliação Da relação entre comportamentos mecânico e hidráulico para lastro ferroviário. Transportes 28 (3), 61–74. https://doi.org/10.14295/transportes.v28i3.1829 (2020)
Pires, J., Costa, R., Bernucci, L., Motta, R. & Moura, E. Degradação do lastro ferroviário – principais aspectos e estudos de caso. Transportes 25 (3), 62–74. https://doi.org/10.14295/transportes.v25i3.1340 (2017)
Indraratna, B., Thakur, P. K. & Vinod, J. S. Experimental and numerical study of railway ballast behaviour under cyclic loading. Int. J. Geomech. https://doi.org/10.1061/(ASGE)GM.1943-5622.0000055 (2010)
Comparison of the permeability of potential ballast rocks from Northern Rio De Janeiro state under different fouling rates after sodium sulfate attack
Guo, Y. et al. Railway ballast material selection and evaluation: a review. Constr. Build. Mater. 344, 128218. https://doi.org/10.1016/j.conbuildmat.2022.128218 (2022)
Lastro ferroviário de granitos e rocha básica em regiões tropicais: relações entre petrografia
propriedades físico-mecânicas e de alterabilidade
Esfahani, M. K., Kamani, M. & Ajalloeian, R. An investigation of the general relationships between abrasion resistance of aggregates and rock aggregate properties. Bull. Eng. Geol. Environ. 78 (60), 3959–3968. https://doi.org/10.1007/s10064-018-1366-7 (2019)
Sadegui, J. M., Zakeri, J. A. & Najaer, M. E. M. Developing track ballast characteristic guideline in order to evaluate its performance. Int. J. Railway 9 (2), 27–35. https://doi.org/10.7782/IJR.2016.9.2.027 (2016)
Tecnologia de rochas na construção Civil 132 (ABGE
Xie, X. L. et al. A review of test methods for uniaxial compressive strength of rocks: theory, apparatus and data processing. J. Rock. Mech. Geotech. Eng. https://doi.org/10.1016/j.jrmge.2024.05.003 (2024)
Correlations between petrography and technological properties of rocks: application as railway ballast
Singh, T. N., Kainthola, A. & Venkatesh, A. Correlation between point load index and uniaxial compressive strength for different rock types. Rock. Mech. Rock. Eng. 45, 259–264. https://doi.org/10.1007/s00603-011-0192-z (2012)
Basu, A. & Aydin, A. Predicting uniaxial compressive strength by point load test: significance of cone penetration. Rock. Mech. Rock. Eng. 39, 483–490. https://doi.org/10.1007/s00603-006-0082-y (2006)
Al-Harthi, A. A. A field index to determine the strength characteristics of crushed aggregate. Bull. Eng. Geol. Environ. 60, 193–200. https://doi.org/10.1007/s100640100107 (2001)
Wang, M. & Wan, W. A new empirical formula for evaluating uniaxial compressive strength using the Schmidt hammer test. Int. J. Rock. Mech. Min. Sci. 123, 04094. https://doi.org/10.1016/j.ijrmms.2019.104094 (2019)
Basu, A. & Aydin, A. A method for normalization of Schmidt hammer rebound values. Int. J. Rock. Mech. Min. Sci. (41), 1211–1214. https://doi.org/10.1016/j.ijrmms.2004.05.001
Yasar, E. & Erdogan, Y. Estimation of rock physicomechanical properties using hardness methods. Eng. Geol. https://doi.org/10.1016/S0013-7952(03)00141-8 (2004)
Tugrul, A. & Zarif, I. H. Correlation of mineralogical and textural characteristics with engineering properties of selected granitic rocks from Turkey. Eng. Geol. 51, 303–317. https://doi.org/10.1016/S0013-7952(98)00071-4 (1999)
Apaydın, Ö. F. & Yılmaz, M. Correlation of petrographic and chemical characteristics with strength and durability of basalts as railway aggregates determined by ballast fouling. Bull. Eng. Geol. Environ. 80 (6), 4197–4205. https://doi.org/10.1007/s10064-019-01654-4 (2021)
Çelik, M. Y. & Aygün, A. The effect of salt crystallization on degradation of volcanic building stones by sodium sulfates and sodium chlorides. Bull. Eng. Geol. Environ. 78, 3509–3529. https://doi.org/10.1007/s10064-018-1354-y (2019)
Van Blerk, P. G. L., Fletcher, E., Costello, S. B. & Henning, T. F. P. Ethylene glycol accelerated weathering test: an improved, objective aggregate durability test method. Transp. Res. Rec. 2655 (1), 27–35. https://doi.org/10.3141/2655-05 (2017)
Maior parte das obras ferroviárias no Brasil é Voltada para mobilidade urbana
Perrotta, M. M. et al. Geologia e recursos minerais do estado de São Paulo: Sistema de Informações Geográficas - SIG. Rio de janeiro: CPRM, 2006. Programa Geologia do Brasil. https://rigeo.sgb.gov.br/handle/doc/2966
Aggregates – Petrographic Analysis of Aggregate for Concrete
Part 2: Coarse Aggregate (Brazilian Technical Standards Association
Part 1: Petrographic Examination (Brazilian Technical Standards Association
Railway – Ballast – Requirements and test Methods (Brazilian Technical Standards Association
Coarse aggregate - Abrasion test in the Los Angeles Machine (Brazilian Technical Standards Association
Aggregates – Determination of Strength to Crushing of Coarse aggregate – Test Method (Brazilian Technical Standards Association
D5731. Standard test method for determination of the point load strength index of rock. American society for testing and materials. https://www.astm.org/d5731-16.html
D5873. Standard test method for determination of rock hardness by rebound hammer method. American society for testing and materials. https://www.astm.org/d5873-14.html
C88. Standard test method for soundness of aggregates by use of sodium sulfate or magnesium sulfate. American standard testing materials, West Conshohocken. https://doi.org/10.1520/C0088_C0088M-18 (2018)
An evaluation of the relationship between unconfined compressive strength and point load strength index
Heidari, M., Mohseni, H. & Jalali, S. H. Prediction of uniaxial compressive strength of some sedimentary rocks by fuzzy and regression models. Geotech. Geol. Eng. 36 (1). https://doi.org/10.1007/s10706-017-0334-5 (2018)
Tandon, R. S. & Gupta, V. Estimation of strength characteristics of different himalayan rocks from Schmidt hammer rebound, point load index, and compressional wave velocity. Bull. Eng. Geol. Environ. 74, 521–533. https://doi.org/10.1007/s10064-014-0629-1 (2015)
Basu, A. & Aydin, A. A method for normalization of Schmidt hammer rebound values. Int. J. Rock. Mech. Min. Sci. 42 (2), 215–220. https://doi.org/10.1016/j.ijrmms.2004.05.001 (2005)
Yagiz, S. Predicting uniaxial compressive strength, modulus of elasticity and index properties of rocks using the Schmidt hammer. Bull. Eng. Geol. Environ. 68, 55–63. https://doi.org/10.1007/s10064-008-0172-z (2009)
SABS 1083 - Aggregates from natural sources- South African Bureau standards
A importância das características tecnológicas da pedra britada para lastro ferroviário
Geologic characterization of natural aggregate: a field geologist’s guide to natural aggregate resource assessment
Kazi, A. & Al-Mansour, Z. R. Influence of geological factors on abrasion and soundness characteristics of aggregates. Eng. Geol. 15 (3–4), 195–203. https://doi.org/10.1016/0013-7952(80)90034-4 (1980)
Download references
The authors would like to thank the Engineering Geology and Road laboratories (EESC-USP) and Geotechnics Laboratory (UFSCar) for the opportunity and for all the infrastructure offered to carry out the physical-mechanical and alterability tests
The authors acknowledge the Brazilian governmental research agencies CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
by CAPES research fellowships and by CNPq through the research fellowship PQ2 316330/2021-3
UENF – State University of the North in Rio de Janeiro
The authors declare no competing interests
All methods were performed in accordance with the relevant guidelines and regulations
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
Download citation
DOI: https://doi.org/10.1038/s41598-024-83929-9
Anyone you share the following link with will be able to read this content:
Sorry, a shareable link is not currently available for this article.
Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.
O endereço abaixo não existe na globo.com
This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data.
You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.
SAO CARLOS (FIBA Americas Championship 2007) – Brazilian center, Nene, announced his return to the Brazilian National team. The news was posted just a few minutes ago on his webpage.\r\nIn an interview that took place on his native Sao Carlos, the player from the Denver Nuggets confirmed his return to the team which will be active on the FIBA Americas ...
HomeNewsBRA – Nene, back in the National TeamFIBA BasketballBRA – Nene
back in the National TeamSAO CARLOS (FIBA Americas Championship 2007) – Brazilian center
announced his return to the Brazilian National team
The news was posted just a few minutes ago on his webpage
In an interview that took place on his native Sao Carlos
the player from the Denver Nuggets confirmed his return to the team which will be active on the FIBA Americas ..
SAO CARLOS (FIBA Americas Championship 2007) – Brazilian center
the player from the Denver Nuggets confirmed his return to the team which will be active on the FIBA Americas Championship 2007 in Las Vegas
Recent conversations with his family and some friends push to take the decision of coming back
my team and just realized that it was time to come back”
help them to get to the Olympics in Beijing.”
“I am wishing for a new life with the National team
What happened is in the past; now it’s time to defend my country
This is the moment to rescue it,” concluded Nene
Today's print edition
Home Delivery
South America is being ravaged by fire from Brazil's Amazon rainforest through the world's largest wetlands to dry forests in Bolivia
breaking a previous record for the number of blazes seen in a year up to Sept
Satellite data analyzed by Brazil's space research agency Inpe has registered 346,112 fire hot spots so far this year in all 13 countries of South America
topping the earlier 2007 record of 345,322 hot spots in a data series that goes back to 1998.googletag.cmd.push(function() { googletag.display('div-gpt-ad-1499653692894-0'); });
Smoke billowing from the Brazilian fires has darkened the skies above cities like Sao Paulo
feeding into a corridor of wildfire smoke seen from space stretching diagonally across the continent from Colombia in the northwest to Uruguay in the southeast
Brazil and Bolivia have dispatched thousands of firefighters to attempt to control the blazes
but remain mostly at the mercy of extreme weather fueling the fires
Scientists say that while most fires are set by humans
the recent hot and dry conditions being driven by climate change are helping the fires spread more quickly
South America has been hit by a series of heat waves since last year
said of the weather in Sao Paulo in recent months
Despite still being winter in the Southern Hemisphere
high temperatures in Sao Paulo have held at over 32 degrees Celsius since Saturday
Hundreds of people marched in Bolivia's highland
political capital La Paz to demand action against the fires
holding banners and placards saying "Bolivia in flames" and "For cleaner air stop burning."
"Please realize what is really happening in the country
we have lost millions of hectares," said Fernanda Negron
"Millions of animals have been burned to death."
a drought that began last year has become the worst on record
according to national disaster monitoring agency Cemaden
long-lasting in some regions and extensive in recent history
at least in the data since 1950," said Ana Paula Cunha
The greatest number of fires this month is in Brazil and Bolivia
Unusually intense fires that hit Venezuela
Guyana and Colombia earlier in the year contributed to the record but have largely subsided
Fire from deforestation in the Amazon creates particularly intense smoke because of the density of the vegetation burning
"The sensation you get flying next to one of these plumes is like that of an atomic mushroom cloud," said Longo
Roughly 9 million square kilometers of South America have been covered in smoke at times
the most populous city in the Western Hemisphere
earlier this week had the worst air quality globally
higher than famous pollution hot spots like China and India
Bolivia's capital of La Paz was similarly blanketed in smoke
Exposure to the smoke will drive up the number of people seeking hospital treatment for respiratory issues and may cause thousands of premature deaths
Inhaling wildfire smoke contributes to an average 12,000 early deaths a year in South America
according to a 2023 study in the academic journal Environmental Research: Health
September is typically the peak month for fires in South America
It's unclear whether the continent will continue to have high numbers of fires this year
While rain is forecast next week for Brazil's center south
drought conditions are expected to continue through October in Brazil's northern Amazon region and center-west agricultural region
In a time of both misinformation and too much information
quality journalism is more crucial than ever.By subscribing
Your subscription plan doesn't allow commenting. To learn more see our FAQ
Sponsored contents planned and edited by JT Media Enterprise Division.
Flooding struck after a short period of torrential rainfall
138mm of rain fell between in just over 1 hour
which is more than the November monthly average
The force of the floods was so strong that it dragged 37 vehicles along city streets
Around 40 homes were also damaged and three houses completely destroyed
However there were no reports of fatalities as of 28 November
The state government said that around 130 businesses had suffered severe damaged
A state of emergency has been declared for the city
BrazilBreaking News
Richard Davies is the founder of floodlist.com and reports on flooding news
Indonesia – Floods Damage Thousands of Homes in North Sumatra Province
India – Deadly Floods in Andhra Pradesh After Rain from Cyclone Nivar
Cookies | Privacy | Contacts
© Copyright 2025 FloodList
realized for a young couple and their children
the contemporary dwelling is carefully planned to afford visual connection between spaces while providing privacy from street.
images by favaro junior
the unconventional shape of the site and the requirement to leave a six-meter strip along the street edge informed lb+mr‘s final design
the architects wanted to create a home that would fit delicately into the land while allowing cross-ventilation and natural light to pass through the interiors
they shaped KT house from clear volumes and natural materials
giving it a robust yet relaxed aesthetic.
as well as fitting the program into the triangular site, another aim of the project was to guarantee visual connection throughout the floor plan. to achieve this, the house is organized around a central courtyard that connects three well-defined wings: service
wooden brises and glass panels on these courtyard-facing elevations allow the spaces to be completely opened to the outdoors or closed off for privacy
the project includes a triangular-shaped swimming pool
where the family can take a dip or relax by the decking at the side
there is the six-meter strip that serves as an extension of the courtyard
following the same concept that led the entire project: granting visual connection while maintaining residents’ privacy by the subtle use of dense vegetation and ground elevation
location: condomínio damha golf
architect: lb+mr | @lucianabernasconi_milaricetti
structural engineer: ana cristina fernandez
lighting: jabu engenharia elétrica
photography: favaro junior | @favarojrfotografia
AXOR presents three bathroom concepts that are not merely places of function
but destinations in themselves — sanctuaries of style
Professor Roblyer visited the University of Sao Paulo in Sao Carlos over spring break
and got to learn all about the fabulous research in photodynamic therapy happening at the center
View all posts
EA211: 1.0L MPI, 1.6L MSI, 1.0L TSI, 1.4L TSI EA111 (After Sales): Rumpf Motor 1.6L MPI, Rumpf Motor 1.0L MPI
The Volkswagen Newsroom is an open platform and offers comprehensive search options to all users.
If you would like to be kept informed about our press releases you can also subscribe to our media information newsletter.
Parece que a página que você está procurando não está disponível.
Reading"Non-Verbal Club's..."
More fromWork
Contact
Advertising Opportunities
Newsletters
Insights + Opinion
Creatives + Projects
Advice + Resources
Culture + Lifestyle
Nicer Tuesdays
The View From...
POV
Forward Thinking
Review of the Year
Jenny Brewer
Olivia Hingley
Ellis Tree
Elizabeth Goodspeed
Liz Gorny
Extra Search
the studio recently utilised this balancing act to create a beautifully sleek identity for Teatro Nacional de São Carlos
covers a programme of operas as well as classical music concerts and is the home of the National Symphonic Orchestra
Non–Verbal Club started by analysing the theatre’s current visual communication
after which they rewrote the brief “with the key topics we believe were important to change.” This is typical of Non–Verbal Club’s practice
who create projects rooted in thorough research and collaboration
“We often rework the briefs we receive and do not shy away from looking for more than what the projects actually are
finding which new possibilities they open,” it explains
After meeting with TNSC’s artistic director
the studio set about developing an identity which reflected the theatre’s ambitions
Non–Verbal Club’s projects often feature typography-heavy designs
These are produced by anchoring projects in several key concepts that “provide the mechanics for [the project] to naturally unfold,” and this was very much the case when it came to designing TNSC’s identity
“It was fairly evident that São Carlos needed change – new and fresh visual strategies that would meet a bolder attitude in the way it communicates,” the studio recalls
Deciding to highlight the “stars” of the theatre
Non-Verbal Club developed a system with the names of composers
The upcoming season had two facets which needed to be communicated in a distinct yet complementary way: the lyrical season of operas and the symphonic season of classical and chamber music concerts
“That led us to create a communication matrix using simple typographic structures and an elementary principle – contrast,” Non–Verbal Club explains
the lyrical season is presented in a white-on-black
whereas the symphonic season appears on a black background in a serif font
Non–Verbal Club also designed a programme book for the entire season
The book features an elegantly thin format
the letters TNSC set in a large point size on its cover
An extremely bold aesthetic for an institution of this kind
the cover then reveals a beautiful fold-out image when opened
After producing the initial monochromatic poster campaign
Non–Verbal Club began to introduce new colour schemes to “create variations of the structure and added emotion.”
Non–Verbal Club’s Swiss-inspired design is visually arresting but is also supported by rationale
The studio’s “utter obsession” with typography is made clear through their bold use of lettering
producing a contemporary and exciting solution for an institution so steeped in history
Non–Verbal Club: Teatro Nacional de São Carlos identity
Further Infononverbalclub.pt
Ruby Boddington
Ruby joined the It’s Nice That team as an editorial assistant in September 2017 after graduating from the Graphic Communication Design course at Central Saint Martins
she became a staff writer and in August 2019
Fancy a bit of It's Nice That in your inbox
Sign up to our newsletters and we'll keep you in the loop with everything good going on in the creative world
Instagram
TikTok
LinkedIn
Facebook
Twitter
Pinterest
About
Careers at It’s Nice That
Privacy Policy
Insights
Residence
Creative Lives in Progress
If You Could Jobs
© It’s Nice That 2024 · Nice Face Logo © It’s Nice That
nonverbalclub.pt
“We like to look at our practice as a balancing act between rationality and emotion,” states Porto-based graphic design studio
The European foundry’s wildly variable typeface
perfectly encapsulates Gruppo Due’s inquisitive
the studio looked to the slow and quiet processes of the natural world for inspiration
Each weight of this variable typeface degrades in resolution until its letterforms are an abstract mass of pixels
things go from readable weights to “decorative extremes” with imaginative methods of integrating motion
About
Contact
Advertising Opportunities
Newsletters
Insights + Opinion
Creatives + Projects
Advice + Resources
Culture + Lifestyle
Nicer Tuesdays
The View From...
POV
Forward Thinking
Review of the Year
Jenny Brewer
Olivia Hingley
Ellis Tree
Elizabeth Goodspeed
Liz Gorny
Instagram
TikTok
LinkedIn
Facebook
Twitter
Pinterest
Careers at It’s Nice That
Privacy Policy
Insights
Residence
Creative Lives in Progress
If You Could Jobs
For the latest updates on the 2020 F1 schedule, see f1.com/coronavirus-latest
Building work began on what ended up being called the Autodromo Jose Carlos Pace – but what is more commonly referred to as Interlagos – all the way back in 1938. The track designers took their inspiration from three main circuits: Brooklands in the UK, Roosevelt Raceway in the USA and Montlhery in France.
Buoyed by the success of Brazil’s Emerson Fittipaldi, Formula 1 first jetted into Interlagos for a world championship race in 1973. Fans were treated to a home win in the first three Brazilian Grands Prix, with Fittipaldi victorious in 1973 and 1974, while Carlos Pace won in 1975.
Like many pre-World War II tracks, Interlagos features banked corners, with the drivers beginning their lap on a sort of half oval – in fact, between 1957 and the track’s return to the F1 calendar in 1990, Interlagos could be run as a giant oval. After wiggling through the Senna S and down to Turn 4, the drivers then go through a snaking in-field section with some challenging camber changes, before slinging back up the hill and through the banked final turn.
A carnival atmosphere really does dominate in Brazil, and watching Formula 1 cars alongside the locals is something every F1 fan should experience. True, it doesn’t look like there’ll be a local driver to cheer on any time soon, but that won’t stop the party at Interlagos.
Because of the bowl-like nature of the track, a place in Grandstand A on the banked entry to the start-finish straight will give you a double whammy of views, allowing you to see the cars winding through the infield section and then passing underneath you. On the other end of the straight, Grandstand M will put you on top of the first corner and the Senna S, the best spot to watch overtakes on the track.
© 2003-2025 Formula One World Championship Limited
each person hooked to an array of machines tracking their vitals with a cacophony of beeps and alarms.The two nurses developed the method about a month ago
as the current brutal surge in COVID-19 was gaining speed
Brazil is now leading the world in daily average COVID-19 deaths and is second only to the United States in total death toll.Warming patients hands has several benefits beyond the emotional support it can provide
including increased blood flow.Cold hands can result in incorrect readings of patients' blood oxygen levels
falsely showing that oxygen levels are low
The gloves ensure that doesn't happen.Hospitals around the city are now using the technique
with staff praising the "hands of love" for delivering immediate results."It's unbelievable that you can see how fast the change in the patient is
it's magnificent," Cunha said.Reporting by Leonardo Benassatto; Writing by Jake Spring; Editing by Andrea Ricci
Our Standards: The Thomson Reuters Trust Principles., opens new tab
, opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts.
, opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks.
© 2025 Reuters. All rights reserved
Fundação de Amparo à Pesquisa do Estado de São Paulo
Consumption of medical drugs such as painkillers
antidepressants and antivirals is rising at breakneck speed
Sales of such drugs are set to reach USD 1.8 trillion worldwide by 2026
The trend reflects the aging of the global population and more frequent outbreaks of epidemic diseases
because these drugs are often prescribed in standardized dosages regardless of the patient’s metabolism
clinical conditions and nutritional health
and scientists and physicians are increasingly turning to personalized prescriptions.
researchers affiliated with the University of São Paulo’s São Carlos Institute of Physics (IFSC-USP) and São Carlos Institute of Chemistry (IQSC-USP) in Brazil have developed a simple
cheap and flexible sensor that rapidly analyzes saliva to detect paracetamol
and monitors its action in real time to permit dosage correction
An article reporting the research is published in the journal Small: nano micro and featured on the frontispiece of the March 22 issue
After administration of a single dose in an oral pill
electrodes on the surface of the device can detect the drug quickly and non-invasively in a small sample of human saliva
thanks to oxidation of the active ingredient by the sensors to produce an electric current.
“The protocol is promising for observation and correction of fluctuations in absorption of paracetamol and response to the drug,” said Paulo Augusto Raymundo Pereira, last author of the article and a researcher at IFSC-USP
“An imprecise dosage can have harmful effects not only on the treatment but also on the patient’s organism.”
Paracetamol (also known as acetaminophen) is the main non-opioid analgesic recommended for mild pain by the World Health Organization (WHO)
but its excessive consumption is associated with liver and kidney problems caused by the accumulation of toxic metabolites
as well as gastrointestinal bleeding and anemia
According to the American Liver Foundation (ALF)
paracetamol is the leading cause of liver failure in the United States
Overdoses of the drug cause 458 deaths per year in the United States
according to studies of archives and databases; 100 are unintentional
The real number of health problems and hospitalizations is likely to be far higher
Specialists warn that a physician should always be consulted before taking any over-the-counter drug
above all if the patient has a history of liver or kidney disease
and the recommended dosage should always be followed
“In addition, our methodology would also help reduce water contamination. Pills are often quite wrongly thrown away in the garbage, and some of the paracetamol ingested is not metabolized but excreted in urine. Wastewater treatment plants aren’t 100% efficient in removing pharmaceuticals,” said Nathalia Oezau Gomes
a chemist and co-author of the article.
The research was supported by FAPESP (projects 16/01919-6 and 20/09587-8)
The device was fabricated with a similar methodology to the silkscreen technique used to print T-shirts
A portion of conductive carbon paste was placed on a screen with the sensor diagram
under which lay a sheet of store-bought clear polyester transparency film
The paste was then dispersed with a squeegee
The device is portable and uses low-cost sensors
each priced at less than USD 0.02 (two cents)
far cheaper than comparable instruments used for this type of analysis
which are often bulky and require trained operators
The choice of saliva for detection purposes also has advantages
such as ease of collection and the fact that saliva secretion reflects the level of free analytes (or sample components)
saliva is increasingly used in therapeutic drug monitoring thanks to the relatively low cost of collection
shipping and processing in a central laboratory
“The results of our study demonstrate the significant potential of a simple strategy,” Pereira said
“Low-cost electrochemical devices are increasingly seen as an attractive alternative for therapeutic drug monitoring thanks to their analytical characteristics
and the possibility of in situ real-time analysis.”
and is ready for technology transfer to a future partner company interested in mass-producing and marketing the device
Next steps will include trials involving a larger number of volunteers and comparison of the data obtained with a gold-standard technique
About São Paulo Research Foundation (FAPESP)
10.1002/smll.202206753
On-Site Therapeutic Drug Monitoring of Paracetamol Analgesic in Non-Invasively Collected Saliva for Personalized Medicine
are not responsible for the accuracy of news releases posted to EurekAlert
by contributing institutions or for the use of any information through the EurekAlert system
Copyright © 2025 by the American Association for the Advancement of Science (AAAS)
The University of Bath is proud to announce a new collaboration with the UFSCar in Brazil to enable joint research on solar energy and green chemistry
Led by Professor Frank Marken
a professor in the Department of Chemistry
the collaboration between both universities will facilitate access to new CAPES/PrInt funding from the Brazilian Ministry of Education and support the exchange of researchers between both institutions
CAPES/PrInt is a a program encouraging student exchanges with international research institutions between São Carlos and other research organisations in Brazil and fosters the internationalisation of academic programs
The exchange of researchers and the joint publications generated under this agreement will enhance Bath's visibility in the region and enable long-term links and funding opportunities between Bath and São Carlos
but also between Bath and other research organisations in Brazil
This new agreement follows the recent MoU renewal with the University of São Paulo
one of Bath's longstanding Brazilian partners
Professor Marken commented the new partnership:
The exchange of researchers will contribute to international visibility and have a long-term impact on linking UK and Brazil scientists
The project will help educate students and explore new ways to use solar energy replacing fossil fuels
The University of Bath is proud to formalise a collaboration with the Federal University of São Carlos and looks forward to seeing the successes of this partnership
“Our main goal is to improve the results from Sochi in terms of performance and number of athletes.”
As part of Brazil’s Para Nordic skiing development programme
a Para roller-ski competition was held in the city of Sao Carlos on 15 October with six Brazilian male skiers taking part in the sitting and standing categories
Fernando Aranha (11:53.3) was the fastest in the men’s sitting
Everaldo Arando (18:13.8) and Altair Marangne (23:53.3)
Thomaz De Moraes clocked 11:51.60 and Gustavo Silva 13:23.10
located in the ‘Parque Eco-Esportivo Damha’
we have been trying to recruit more athletes to the sport and have been developing a programme to prepare young athletes with potential for the future," said Leandro Ribela
who coordinates the Olympic and Paralympic cross-country skiing programmes in Brazil
"We want to train more coaches to work with Paralympic winter sports in Brazil
We have very good coaches for the summer sports
so I believe we can use their expertise to train Para Nordic skiing coaches.”
Brazil made their first appearance at the Paralympic Winter Games in Sochi
through snowboarder Andre Cintra and Nordic skier Aranha
we seek to have three athletes qualified for PyeongChang 2018
our main goal is to improve the results from Sochi in terms of performance and number of athletes,” added Ribela
“But our main goals are for Beijing 2022 and the 2026 Games
where we aim to have an athlete amongst the top 10 in one of the events and
We have some good young athletes with potential for the future
Lisbon has always had a rich and vibrant cultural offer and every week there are many concerts and plays in these theaters that enliven the capital
Some of these concert halls in Lisbon are spaces of enormous beauty
with auditoriums to amphitheatres that are incredible and full of curiosities
Here are the venues we’ve chosen as the most charismatic in our city
was inaugurated in 1793 and is the only national theater “dedicated to the production and presentation of opera and choral and symphonic music”
and is probably the finest example of the neoclassical style
the Coliseu dos Recreios presented an architectural innovation: the iron dome
It has always been the most popular concert hall and still retains this use today
it hosted opera sessions in collaboration with the São Carlos
Address: Rua das Portas de Santo Antão 96 (Rossio)
With a capacity for more than 1,200 people
the Calouste Gulbenkian Foundation’s Grand Auditorium hosted its inaugural concert on October 3
with the Gulbenkian Chamber Orchestra and Gulbenkian Choir
The glass at the back of the hall offers a wide view of the Gulbenkian gardens
It is one of the most beautiful venues in Lisbon and hosts events ranging from theater to dance
de Berna 45 A (Praça de Espanha/Avenidas Novas)
Amélia and later Teatro República; since 1918 it has been Teatro São Luiz
it was modeled on the European theaters of the last century and for a long time functioned as a cinema
In May 1971 it was acquired by the Lisbon City Council and since then it has established itself as one of the best theaters in Lisbon to see a good play
Address: Rua António Maria Cardoso 38 (Chiado)
the curtains are velvet and the walls are made of wood; all of which makes this one of the most charismatic and seductive venues in the city
The back of the stage holds a well-hidden secret: behind the curtain
a huge window that communicates with the outside of the building
Address: Rua Arco do Cego 77 (Campo Pequeno)
Inside it may not be the most interesting space
but outside it is imposing and possesses a simple
the theater was officially inaugurated on July 10
it was classified as a Property of Public Interest in 1983
but in 2016 it was rehabilitated and once again became an active concert hall with a vibrant artistic and cultural program
Address: Parque Mayer (Avenida da Liberdade)
the Aula Magna of the Rectory of the University of Lisbon is a unique hall in Portugal and
was also dubbed the “largest hall in the country”
was designed by Daciano da Costa – architect
designer and leading figure in Portuguese design
Address: Alameda da Universidade (Cidade Universitária)
the Luís de Camões Theatre was intended as the opera house of King João V
the venue underwent refurbishment works promoted by the Lisbon City Council and
it reopened as a municipal theater dedicated to the youngest and the artistic program is dedicated exclusively to children and young people
Campo Pequeno is considered Portugal’s main bullfighting arena and is also considered a cultural and historical heritage site and
Famous for its unique Muslim-style architecture
where neo-Moorish and neo-Gothic features stand out
Campo Pequeno has a capacity for 8,000 people and is often used as a venue for shows
in our opinion one of the best in the city
This is undoubtedly one of the venues in Lisbon that has had more names: it was the Utopia Pavilion during Expo 98
then the Atlantic Pavilion when the world expo ended
then it took on the name of a telecommunications brand
which more recently also changed its name to Altice Arena … and then back to Meo Arena
or an upside-down caravel by others (when seen from the inside)
the Meo Arena is the largest concert venue in the city
Honorable Mention in the Valmor Prize in 2001
this piece of architecture designed by the Portuguese architect Regino Cruz
is the stage for the biggest performances in the capital
such as the hosting of the Eurovision Song Contest in 2018
Address: Rossio dos Olivais (Parque das Nações)
In addition to Lisbon’s iconic concert halls, iconic places in the capital such as the Altis Grand Hotel
Santa Catarina Church and the Royal Treasure Museum combine timeless beauty with the light of Candlelight concerts
For those looking for an unforgettable evening immersed in Lisbon’s history and culture
candlelight concerts are undoubtedly an unmissable choice
images by favaro junior
LLP house is positioned on an elevated site that offers both privacy and views. when developing the design, lb+mr‘s main goal was to integrate the building into the natural surroundings and create a refuge from daily urban life
the team shaped the residence with a ‘beachside house’ in mind; they incorporated large openings
formed outdoor living spaces and used regional materials such as stone
residents enter the house from the street elevation via a set of stairs from the underground level
this smaller underground floor contains a garage
the rest of the program is housed on the first floor
where a large living room serves as the heart of the home
this central point connects to an indoor-outdoor ‘gourmet area’ by glass and wooden doors that can be retracted behind slatted panels made from freijó wood
a traditional element found in brazilian architecture that generates a warm
the indoor-outdoor gourmet area contains a second kitchen
dining and living space that extends outside to a swimming pool
the pool is curved to create a satisfying contrast with the rest of the straight-edged architecture
the swimming pool sinks into the landscaping like a natural lake
there’s also a sauna/spa that connects to the master bedroom suite and the pool through a submerged passage
residents can find plenty of relaxation both inside and outside
architect: lb+mr | @lucianabernasconi_milaricetti
design team: luciana bernasconi (creative director)
structural engineer: faustino sanches junior
photography: favaro junior | @favarojrfotografia
talks about her academic career and her work advocating science and education
Léo Ramos Chaves / Revista Pesquisa FAPESP
At a three-hour event held in an auditorium at the São Carlos Institute of Physics of the University of São Paulo (IFSC-USP)
and staff took turns at the lectern to highlight the scientific importance and contributions of physicist Yvonne Primerano Mascarenhas
The ceremony was originally set to take place in 2021 as a celebration of her 90th birthday
but it was postponed due to the pandemic and was finally held on the afternoon of September 16
One thing all the testimonies had in common was their emphasis on the role the researcher has played in the life and career of her colleagues and students
in establishing the field of crystallography in Brazil
she was the institute’s first director after it split from the former São Carlos Physics and Chemistry Institute at USP
where she had been working since the mid-1950s
She talked about her career in an interview with Pesquisa FAPESP
One of the points repeatedly highlighted in the tribute you received was your role in establishing USP’s scientific and academic structure in São Carlos
I started working at the Crystallography Laboratory in the USA
It was an extraordinary opportunity to be part of a group using computers to carry out the long calculations needed to determine the molecular and crystal structure of substances based on the intensities of diffracted beams
The University of Pittsburgh had an IBM 650 computer
which had been launched by IBM a year earlier
try to get in touch with other research groups
because they need to know about the molecular structures of the materials they study
This will give you a chance to spread the idea of using crystallography by X-ray diffraction
shut away in your lab.” So that’s what I did
After giving a seminar at USP’s Institute of Chemistry
I established the first structures in collaboration with Otto Gotlieb [1920–2011] and Ernesto Giesbrecht [1921–1996]
The only existing computer at USP—an IBM 1620—was at the Polytechnic School
So I began traveling to São Paulo on a regular basis to use it for about two hours at a time
I strongly insisted that some of the funding received by our Physics Department at the São Carlos School of Engineering [EESC] be dedicated to buying a computer and in the end we got one thanks to funding from the IDB [Inter-American Development Bank]
The first computer was shared by various departments and helped boost computer research for many groups at USP in São Carlos
The first computer at USP’s São Carlos campus was an IBM 1130—the successor to the IBM 1620
The Data Processing Center (CPD) was opened
which modernized the teaching and research of all departments at the EESC
which at the time was the only school on the campus
the school’s faculty grew more skilled at using computers
professor Odelar Leite Linhares [1924–2004] made a great contribution when he began teaching computational methods
The area developed quickly and impressively at the EESC’s former Department of Mathematics
leading to the creation of the Institute of Mathematics and Computer Science (ICMC)
And how was computerization important to the development of crystallography
I learned about the computerization of a collection of X-ray diffraction measurements during a brief visit to Pittsburgh
There was a massive difference between this new methodology and the old methods
which used photographic techniques to record diffraction data
I submitted a research proposal to FAPESP a few years later—it was approved and our laboratory got its first diffractometer for X-ray diffraction in 1975
One important detail is that this diffractometer was automated by a 1620 digital computer
which also allowed calculations to be performed
This feature was soon utilized by other members of our department
Since the 1970s I have been determined to spread the importance of modern theoretical methods for identifying structures
especially among the Latin American community
In 1976 we organized a beautiful Latin American course on direct methods for structure determination
and Chile started working with us and using the automatic diffractometer after that
You mentioned working with researchers in Latin America
Some ended up actually moving to São Carlos
such as Aldo Craievich and Eduardo Castellano
How did you go about attracting scientists from abroad and what role did they play
In December 1971 I was invited to participate in a meeting of the Ibero-American crystallography group
including Eduardo Ernesto Castellano and Aldo Craievich
but in a different subfield known as small-angle X-ray scattering
I thought it would be wonderful if he could come to Brazil
Castellano only came after we did the Latin American course on direct methods in 1976—he was interested in the automatic diffractometer
Aldo agreed to come and spend some time here in São Carlos with a grant from the CNPq [Brazilian National Council for Scientific and Technological Development] and was later hired as a professor at the IFSC
Castellano came with some others from Argentina and was so happy to get the chance to use the diffractometer
He had a CNPq grant too and a year later he joined as a professor
but he maintained ties with his home institution
One of the reasons to participate in international scientific meetings
is to meet new people and establish collaborations
it yielded excellent results with the arrival of high-level scientists for both short and long periods
Students who enjoyed the project will hold onto that magazine and it will be a positive memory in their school life
you were the first director of the Institute of Physics after it separated from the Institute of Chemistry
I applied for the position after being encouraged to do so by some other professors
It wasn’t difficult being the director
One advantage of the institute is that we have great staff
key employees for different disciplines are retained
When the Institute of Physics and Chemistry was formed [in 1971]
a culture was established that teaching and research were more important than the institution’s administration
which should always be managed consensually
So we initially had consecutive directors who were professors from the Luiz de Queiroz College of Agriculture at USP
How was this culture of prioritizing teaching and research created
The institute is composed of several extremely active research groups
many with an interest in education and scientific communication
My participation in this area is modest compared to what Professor Vanderlei Bagnato does through the Optics Group
And Professor Dietrich Schiel [1940–2012] created the CDCC [Center for Scientific and Cultural Dissemination at USP]
an important communications center in São Carlos that is really well located and used
it has always been essential to attract good teachers
as well as obtaining funding for high-quality projects from funding agencies
as evidenced by our graduate programs being classified as level 7
leaving me with no more administrative or teaching commitments
I decided to continue in the line of scientific communication
I received funding from FAPESP and the CNPq for various projects
I always thought I could offer personal help and looked for schools with teachers interested in receiving this kind of support
I was happy working directly with students and teachers in the school system
There are three schools still running the projects the way we envisioned
I thought I could provide a kind of supplementary education for high school students
One of the projects funded by FAPESP was really successful
through which we provided almost full-time education to students from the Professor Sebastião de Oliveira Rocha State School [EESOR]
chosen with input from Regional Director of Education Débora Blanco
The students had lunch at USP’s university restaurant and returned in the afternoon to take extra classes
The project was initially carried out with students in their first year of high school
These students then went on to the second year
and then they took the university entrance exam
Then I decided to change the focus a little bit and I introduced a project methodology that used information and communication technologies (ICT) with students aged 11 to 14
This methodology worked better for middle school classes than with high school students
High school students are very focused on the university entrance exam
so adherence to multidisciplinary projects
which are long—one project lasts a whole semester—is lower
schools already had access to computers and the students were able to use them for research
They had to read up on the subject in question and then work together to produce a paper
with teachers from various disciplines involved
The reading and writing part was led by the Portuguese teacher and the physics
and mathematics aspects aided by a physics or chemistry teacher
The project resulted in the production of a magazine describing everything the students had done
a teacher talked about students who went to an Olympiad in Europe
That was related to our first high-school project
The students participated in a national and international competition called the International Young Physicists’ Tournament (IYPT)
We formed a team of high-school students from EESOR who won the national round and later participated in the Brazilian team that took first place in the international competition in Prague
These students all achieved fantastic results in their university entrance exams
so it is more difficult to follow what the children involved go on to do
The teachers tell us that these students are more likely to get involved in other initiatives
and take part in decision-making processes—they become more mature
It is really positive to work on projects like this
At the end we have a get-together to celebrate
Everyone takes their own copy of the magazine home
but those who enjoyed the project will hold onto that magazine and it will be a positive memory in their school life
We still educate girls as if they are destined only to be mothers and caregivers
You helped strengthen the São Carlos unit of the USP Institute for Advanced Studies
my late ex-husband Sérgio Mascarenhas had gone to spend a year at the Institute for Advanced Study in Princeton
And USP already had its Institute of Advanced Studies [IEA]
he was really keen to create an IEA branch in São Carlos
They asked me to take part and I told them that one of our fundamental problems was education at all levels
so I wanted to participate in a group dedicated to basic education
The group was formed in early 2001 and we carried out a range of activities
When Professor Paulo Saldiva was director of the IEA
he contacted me and said he was going to create several research groups
He asked me if it would be okay if this group was not based in São Carlos
when Saldiva reached the end of his term he asked Fundação Itaú to fund the group
led by former dean of the Federal University of Southern Bahia
There are so many ideas in this field—I don’t know whether it is possible to implement all of them
especially if they are not too conservative
What are your thoughts on female participation in your area of research
The number of women in the field is reasonable at the national and international level
and even includes some Nobel Prize laureates
I drew up an academic timeline of crystallography in Brazil
on which I only included crystallographers who have supervised at least one doctorate
Most women enter careers like pedagogy or teaching
These were pejoratively described as “waiting for a husband” courses
high schools were either traditional or scientific
Traditional schools were for people who preferred communication
I chose traditional because I loved to read
We had a really good chemistry teacher called Albert Ebert who showed us how science worked
I ended up studying chemistry and a friend of the same age did physics
and she is now professor emeritus at the Brazilian Center for Physics Research (CBPF)
which gives me hope that we will continue to make progress and that gender equality will be achieved in the not-too-distant future
you took action in São Carlos when there was a parliamentary inquiry into universities by the Legislative Assembly of São Paulo
which was critical of the autonomy of state universities
I got in touch with Professor Azuaite Martins
who is a politician from São Carlos with a very good record in the area of education
and I suggested: “Why doesn’t the City Council oppose this inquiry?” And he agreed immediately
Of course I was very grateful because he did what he had to do and persuaded the City Council to speak out unanimously against the inquiry
the IFSC director said that he has plans for you to serve as a kind of ambassador for the institute
I still supervise master’s and doctoral students and I still carry out research
I have close ties with a group here at the institute that is working on conductive polymers
I am always ready to defend science and education
I supported a candidate for federal deputy and a candidate for state deputy who both back science
you have an obligation to think and you can and should influence people who are open to your arguments
© Revista Pesquisa FAPESP - All rights reserved
BV-FAPESP: research projects supported in this Center
CIBFar in the Media: news about the Center
The ultimate goal is the development of new chemical entities (NCEs) with the raised potential of innovation for clinical development. Therefore, the CIBFar is not only based on the abilities and solid scientific knowledge in all the interest areas, but also in an organized structure for the integration of modern approaches in biodiversity and drugs discovery.
CIBfar main characteristic is the well-established infrastructure in terms of skills for technical, financial, technological education, and executive management. Maximum integration with the productive sector will be held to identify opportunities and the definition of goals. In the educational aspect, the Center counts on the significant experience acquired throughout one decade in education and dissemination of the knowledge carried through in the CEPID-FAPESP.
Physicist honored at the World Chemistry Congress began to study molecular structures using X-ray diffraction in the 1960s
Léo Ramos Chaves Physicist from the city of São Carlos identified the structures of the hormone oxytocin and of plant extracts with therapeutic potentialLéo Ramos Chaves
Now at 86, with four children, ten grandchildren, and seven great-grandchildren, Mascarenhas continues to publish scientific articles. One of her recent studies considers a substance extracted from the leaves of the jaborandi plant (Pilocarpus pennatifolius). This substance acts against the worm that causes schistosomiasis. Another study characterizes a protein isolated from the bacterium Bacillus thurigiensis that could be used as an insecticide.
In July, Mascarenhas was one of twelve scientists to receive the award offered by the International Union of Pure and Applied Chemistry (IUPAC) to women with achievements in chemistry or chemical engineering research. She hosted Pesquisa FAPESP in her laboratory at USP São Carlos a few days before traveling to the city of São Paulo to receive the award at the opening of the 46th IUPAC World Chemistry Congress.
What about chemistry interested you? It was the possibility of studying the compounds that make up all substances, including living beings, and the very logical way Professor Ebert presented it all. He helped me see a universe of applications, that it was an extremely important science. As soon as I graduated, Professor Ebert helped me to get a job at the Franco-Brazilian Secondary School in Rio. Years later, he became dean of the School of Education of UFRJ.
Why are single crystals important? To understand the structure of a molecule, we must obtain a single crystal from a solution. A good single crystal has a certain geometric shape according to its symmetry and is transparent, but it must be small. Smaller crystals, up to a hundredth of a millimeter, are becoming more and more viable as X-ray detectors and sources continue to improve.
personal archive Mascarenhas (right) with physicist Herbert Hauptman and his wife
on a visit to a farm in the city of Descalvado after a course in São Carlos in 1976personal archive
The structures I studied were important to the chemists or physicists with whom I have always collaborated
I remember a collaboration with Otto Gottlieb [a Czech-Brazilian chemist
who worked with compounds obtained from plants at the USP Institute of Chemistry and at UFRJ [see Pesquisa FAPESP
He studied substances from the plant Aniba gardineri and could not determine the mechanism of dimerization [the formation of a double structure through the union of two similar units] of one of its molecules
I really enjoyed that work because Otto was happy when he saw the result
He was very interested in the plants of the family Lauraceae
which offer a wide variety of medicinal and industrial uses
The first study I did in the United States was to determine the molecular structure of a barbiturate: violuric acid
The results of its structure were unprecedented in the field of hydrogen bonds because a molecule from water of crystallization was found to have a bifurcated bond—that is
one of its hydrogen atoms bonds to two different atoms of the violuric acid molecule
That’s why the published article was cited with certain frequency
it’s just another example of a scientific finding resulting from good luck
Another study that I consider important was when I determined the structure of oxytocin
a hormone of substantial biological importance
during a stay at the Crystallography Department of Birbeck College in London in collaboration with Sir Tom Blundell
I became interested in the characterization of semicrystalline materials after getting involved with the INCT [the Brazilian National Institute for Bio-Ethanol Science and Technology] in the study of conductive polymers
As part of my student Edgar Sanches’s doctoral program
we were able to clarify several details about polyaniline
both in its conductive form and its insulating form
My interest in natural products resurfaced when I coordinated the Advances
Benefits and Risks of Nanotechnology Applied to Health project within the scope of the NanoBiotec network for CAPES [Brazilian Commission for the Improvement of Higher Education Personnel]
which partly addressed substances of natural origin with pharmacological properties
One of the plants studied was the jaborandi
One of the components extracted from its leaves is already used for medicinal purposes—to treat ophthalmological problems
which contains other plant components diluted in organic solvents
should not simply be thrown into the environment
This led to the idea of analyzing all of the compounds in the extract in search of other substances with properties of interest
This was the topic of study of a research group from the Delta do Parnaíba campus of the Federal University of Piauí
I noticed that the researchers in this group were giving samples of one of these components of the residue to Ana Maria da Costa Ferreira
a professor at the USP Institute of Chemistry
“Do you know about the structure of this molecule?” They said
but we do not have one of the single crystals in there.” Looking at the powder inside the glass
They allowed me to take a sample of the substance to São Carlos
Because it is not ideal for administration as a drug in its natural form
Ana Maria synthesized several derivatives of this substance
The molecular structures of these complexes were also determined in our group
Many students obtained their master’s and PhDs in the crystallography research group in our department
There are now about one hundred researchers with a solid background in structural crystallography at various universities and research centers in Brazil
Your prize at the IUPAC congress was centered around female scientists
How do you see the difficulties faced by women in research
The most traditional universities in the world barred women from enrolling until the mid-twentieth century
In the National School of Philosophy at the former University of Brazil
though there were few women in physical science programs
and there were more in the chemistry program than in the physics program
for what I consider historical and cultural reasons
men hold positions of leadership and decision making
and society is formed in such a way as to keep power in the hands of the dominant groups
A friend of mine was very upset when the members of a hiring committee asked her how she would handle the fact that her husband was already a professor in São Carlos
It’s the kind of thing no one would ask a male candidate
I always say that the struggle for women’s rights
The issue is learning how to exercise those rights
© Revista Pesquisa FAPESP - All rights reserved.
Léo Ramos Chaves Bagnato has published 700 articles on basic physics and applications in healthLéo Ramos Chaves
from the São Carlos Physics Institute (IFSC) at the University of São Paulo
is the 2019 winner of the Almirante Álvaro Alberto Award
which is the highest science and technology honor in Brazil
is awarded by the Brazilian National Council for Scientific and Technological Development (CNPq)
in partnership with the Ministry of Science
has a degree in physics from IFSC and another in materials engineering from the Federal University of São Carlos
He completed his master’s degree at IFSC in 1982
during which he studied the optical properties of inorganic crystals
and he then studied atom cooling and trapping during his PhD at the Massachusetts Institute of Technology (MIT) in the USA (completed in 1987)
he continued his work with cold atoms and Bose-Einstein condensate
He later began researching the use of lasers and light-emitting diodes (LEDs) to aid diagnosis and treatment in dentistry and medicine
Bagnato has published approximately 700 scientific articles and now manages the Optics and Photonics Research Center (CEPOF)
A TAM Airbus A330 and A320 get worked on at the MRO
The location of TAM Airlines’ Maintenance Operation Center (called “MRO” for Maintenance
It is not found at a major airport or even within a large city
It is located about three hours (by car) northwest of Sao Paulo (GRU) in the middle of farm land
with a runway built next to it to fly in the company’s parts
Turns out building your own airport and flying in parts
was not the best business decision and the tractor company went out of business
TAM’s maintenance facility is located about 15 miles from Sao Carlos
TAM saw this as a great opportunity to purchase the land and open their MRO
TAM opened up their MRO about 15 minutes north of Sao Carlos
I was recently invited to check out the facility
and it was a semi-adventure just getting there
TAM’s MRO is located out in the middle of farm fields – Photo: Google Maps
We flew from Congonhas-São Paulo Airport (CGH) to Leite Lopes Airport (RAO)
Then from RAO it was about an hour’s drive to get to the MRO facility
There is a variety of work done at the MRO
what they do not work on are the engines – those are sublet out
This is the shop where composites are worked on
All the work on the Boeing 777s are done in Singapore by Singapore Airlines
When the Airbus A350 is added to TAM’s fleet
it also will be worked on at the Sao Carlos’ facility
An engine says “hell0” from a long hallway
TAM is not the only company that makes use of their many MRO services
and even a few of TAM’s competitors: Azul
It is hard to believe that this complicated facility is located in the middle of farm land
There are about 1,400 employees that work 24 hours per day in three shifts at the TAM MRO. The facility completes about 160 checks on aircraft per year. The airline also completes about 65 of their checks at LAN’s MRO in Santiago and about 100 are sublet out each year
The MRO was hopping with lots of different aircraft (all Airbus) at different stages of being worked on
The location has 11 slots for planes to be worked on and 22 different shops spread throughout the complex
An Airbus A330 is lifted to have work done on it
Many aircraft in TAM’s fleet are leased
the airline needs to prepare the aircraft for return
Sometimes that means putting in a new interior for the next airline or even painting it in the new livery
Other planes just need to be returned to the lessor cleaned up and in perfect working order
there was an Airbus A330 and a A320 being prepared to be returned to the leasing company
This Airbus A330 is being prepped for a new home
I was impressed with how clean and organized the whole facility was
I could see it being a bit confusing remembering where everything is when first starting
but I am sure people are able to learn quickly
Although the MRO is not open to the public
which does offer some views of aircraft being worked on
You can see even more TAM MRO photos on our Flickr account
Disclaimer: TAM paid for my flights to/from Seattle and my accommodations to do this story
EDITOR-IN-CHIEF & FOUNDER - SEATTLE, WA. David has written, consulted, and presented on multiple topics relating to airlines and travel since 2008. He has been quoted and written for a number of news organizations, including BBC, CNN, NBC News, Bloomberg, and others. He is passionate about sharing the complexities, the benefits, and the fun stuff of the airline business. Email me: david@airlinereporter.com
From some of the photos of aircraft covered in black plastic
it appears that TAM MRO does some of their aircraft painting outdoors
I am not sure why the ones outside are covered in plastic. Looks like maybe to protect it from the elements while it is being worked on? https://www.flickr.com/photos/airlinereporter/15022409221/in/set-72157646809048191
They do have a paint hangar, which is this one here: https://www.flickr.com/photos/airlinereporter/15025471345/in/set-72157646809048191
Tam’s 777 maintenance is in Singapore
I am sure they have people working the numbers and realizing that is the most cost effective way for the airline to do it
When asked they said that they had no plans to do 777 maintenance in-house
Sure they will be getting the plane soon enough
but it will be quite some time still until the A350 needs any heavy maintenance
TAM has chosen the A350 as its growth platform over the 777
is not fully known by anyone other than the top executives
TAM will then likely add the A350 MRO capability to its product mix
But they also said that they have plenty of time to prepare for the A350
since it will be awhile before heavier maintenance will be done on the aircraft (at least we hope) because they are so new
Δdocument.getElementById( "ak_js_1" ).setAttribute( "value"
[Trackback] [...] Read More on that Topic: airlinereporter.com/2010/01/listen-to-the-first-episode-of-jetpardy/ [...]
[Trackback] [...] Information on that Topic: airlinereporter.com/2009/11/dfg/ [...]
[Trackback] [...] Read More to that Topic: airlinereporter.com/2011/09/what-you-need-to-know-boeing-is-delivering-their-first-787-dreamliner-to-ana-this-monday/ [...]
[Trackback] [...] Information to that Topic: airlinereporter.com/2008/07/atlanta-airport-the-busiest-in-the-world/ [...]
TU Delft's latest news
Yara Galvão Gobato at the Federal University of São Carlos (UFSCAR) have teamed up to explore Van der Waals Heterostructures for Spintronics via a recent SPRINT grant
The goal of the collaboration has been to combine the expertise of two labs: Van der Zant group’s on fabricating heterostructures involving two-dimensional magnetic materials and Galvão Gobato group’s on optical measurements on semiconductors
Two-dimensional materials form an interesting class of new materials as they can be cleaved to form very thin layers
The properties of such thin layers can be dramatically different from their bulk counter parts
different materials can be stacked on top of each other to form heterostructures with completely new properties
Magnetic systems are of special attention as they can be used in applications such as memories or in which the magnetic spin is used as information carrier
This application field is typically denoted with the term “Spintronics”
The UFSCAR team visited TU Delft twice over the course of the grant
and the TU Delft team visited Brazil twice as well
Yara Galvão Gobato’s visits to the TU Delft in October 2022 and April 2023
she was actively involved in the laboratory works in the Delft group
Herre van der Zant visited Brazil in September 2022 and May 2023
he participated in the Brazilian Workshop on Semiconductor Physics (São José dos Campos-SP) as an invited speaker and visited the laboratories at UFSCAR
Prof Herre van der Zant participated in the Autumn Meeting of Brazilian Physical Society (Ouro Preto-MG) as an invited speaker
He also visited and presented a seminar at the Laboratório Nacional de Luz Síncrotron-Campinas and visited the laboratory of Prof Prof
The main objectives of these visits in Brazil and the Netherlands were to see the research facilities
meet researchers and discuss opportunities of complementary studies on the physical properties of 2D heterostructures
We have also established the design of samples which were prepared in the Netherlands and Brazil
planned several optical experiments in Brazil
presented seminaries for researchers and students from Brazil and the Netherlands
discussed the preliminarily results and draft publications
We also discussed a possible long-term joint research project in van der Waals heterostructures based on 2D magnetic materials
Various experiments were undertaken in Brazil and the Netherlands
the researchers measured the linearly and circularly polarized photoluminescence under magnetic fields up to 9 T oriented along the different crystallographic axis of CrSBr
The experimental results show that the valley and excitonic properties (intensity
and g-factors) of monolayer MoSe2 are strongly influenced by the magnetic order of the CrSBr substrate
Postbus 5 2600 AA Delft The Netherlands Contact and accessibility
Vacancies Reading assistant BrowseAloud Intranet Student portal Donate Disclaimer Privacy & Security
CARINA was the first autonomous car in Latin America to be tested on real city streets (photo: release)
Driverless vehicle can be called using smartphone app
which allows user to use voice commands to say where to go
Agência FAPESP – Anyone who happens to be on the São Carlos campus of the University of São Paulo (USP) in Brazil who sees a taxi moving along the road with no driver
can rest assured that it is not a runaway vehicle
A taxi service using an autonomous vehicle is being tested by researchers at USP’s Mathematics & Computer Science Institute (ICMC) and the same university’s São Carlos School of Engineering
The researchers are completing the final tests and adjusting a few details of the vehicle in preparation for a public demonstration of the autonomous taxi service
“The idea is for a driverless taxi to be called using a smartphone app we’re also developing,” said Denis Wolf
a professor at ICMC-USP and coordinator of the project
Customers will input the destination by voice command or using a touch screen inside the car
The taxi will then return to its parking spot to await the next call,” Wolf told Agência FAPESP
The autonomous taxi service is one of the possible applications imagined by the researchers for CARINA, the Intelligent Robotic Car for Autonomous Navigation (Carro Robótico Inteligente para Navegação Autônoma
in Portuguese) that they have developed over the past few years with support from FAPESP and the National Scientific & Technological Development Council (CNPq) under the aegis of the National Science & Technology Institute for Critical Embedded Systems (INCT-SEC)
a Fiat Palio Weekend Adventure purchased from a dealership and adapted by the researchers with special equipment
One of these was the installation of a continuous mapping system that improves vehicle control and localization as well as route planning
“Route planning for CARINA’s first test run in October 2013 was very simple
based on a GPS system equivalent to sat-nav
The continuous mapping to be used in the next test will enable real-time planning of the car’s route to the destination input by the passenger,” he said
self-driving vehicles localize themselves using a combination of information from GPS sensors and metric maps of the areas in which they are designed to circulate
These maps are specially constructed to pinpoint the vehicles’ street location
even the most sophisticated GPS sensors are subject to failure and are relatively imprecise
owing to the presence of tall buildings and trees
Localization errors are often significant as a result
and loss of the GPS signal for even a few seconds prevents route correction
The metric maps used today are grid based and vulnerable to service interruptions
As part of an ongoing project funded by FAPESP
the researchers plan to replace metric maps with continuous maps developed at the University of Sydney in Australia
duly adapted to enable CARINA to self-localize in São Carlos
Continuous maps use different kinds of additional information on the environment
to aid vehicle localization in vertical and horizontal space
They plot continuous functions between topological spaces
and are far less sensitive to signal interruptions
“Continuous maps permit autonomous vehicle localization based on information like curb height and position
so you don’t depend on GPS sensors,” he said
CARINA maps the area in which it travels by means of two laser sensors
placed at the front and on the roof of the vehicle
as well as 360-degree cameras similar to those used by Google Street View
The vehicle self-localizes based on previously filmed locations featuring details of the surrounding terrain
Two laser sensors also scan 360 degrees and collect 700,000 data points per second
mapping everything around the car in a radius of 50 m and measuring the distance to other cars
as well as their angle and height relative to the vehicle
A twin-lens stereo vision system operates in tandem with the laser sensor installed on the front of the car
gauging the depth of objects around the vehicle and interpreting the position of traffic lanes
“This set of sensors enables the autonomous vehicle to ‘see’ nearby vehicles
measuring their speed and direction so as to avoid the risk of collision,” Wolf said
The researchers have also developed a speed and steering control system based on command software
The car’s maximum speed is currently 60 kph
“The maximum permissible steering control error for an autonomous vehicle is 40 cm
More than that risks putting it on the wrong side of the road and causing a collision with oncoming traffic,” Wolf said
the São Carlos group of researchers was asked by Scania AB to develop an autonomous truck
The Swedish truck and bus maker provided two trucks for the project
in which it invested R$1.2 million (now about US$344,000)
Various devices were fitted to the truck so that the autonomous system can control every movement
including small motors to control the steering wheel and brakes
Speed is controlled by an electronic circuit attached to the accelerator
A computer connected to all systems in the truck is responsible for capturing GPS and other sensor data
and selecting the appropriate command for actions such as accelerating
“The solutions we used in the autonomous truck differed from those used in CARINA owing to differences between the platforms and budgetary constraints,” Wolf said
“We decided to do without the laser sensors used in CARINA
for example: they cost up to twice the price of the car
we used radar to detect obstacles and a pair of stereo cameras at the front of the truck.”
The cameras used by the researchers mimic human vision by capturing two images at a time so that the depth and shape of objects such as traffic lights can be calculated
GPS antennas were installed on top of the cab
and a sensor detects movements of the steering column
one of the features that distinguishes the autonomous truck developed by USP’s São Carlos group from others produced worldwide
such as the Mercedes-Benz Future Truck introduced by Daimler
is the use of continuous maps like those used in CARINA
“Continuous mapping enables the truck we developed to operate on dirt roads or in other situations where there are no lane markings and even in the absence of any traffic signs,” he said
our project is better suited to local conditions.”
The autonomous truck is a prototype and circulates only in a limited area of the São Carlos campus
but the results obtained so far are promising
Septins (the fourth component of the cytoskeleton) - How to Assemble a Molecular Jigsaw
AbstractSeptins represent a fourth (somewhat neglected) component of the cytoskeleton whose involvement in essential intracellular events involving membrane remodeling and barrier formation has become increasingly apparent over recent years
Septins assemble into heteropolimeric filaments based on palindromic oligomers which polymerize end-to-end
For over a decade we have been attempting to understand the rules of assembly which guarantee how each individual subunit assumes its rightful position along the filament and how these subsequently unite into higher order structures which associate with membranes
By accumulating a large number of crystal and cryo-EM structures several features are beginning to emerge
Richard will describe what has been learnt concerning the correct assembly of the inter-subunit interfaces and their unexpected dynamics
the metastable properties of the C-terminal coiled coils and the importance of a polybasic region necessary for forming electrostatic interactions with membranes
This is providing a more coherent picture of septin function and dysfunction
such as occurs in the case of off-target cleavage of septin 2 by the Zika NS2B3 protease
SpeakerProf Richard Charles Garratt has been on the academic staff of the São Carlos Institute of Physics at the University of São Paulo since 1992
After completing a PhD in crystallography at the University of London
he moved to the University of São Paulo
where he was instrumental in establishing the first protein crystallography laboratory in Brazil and possibly Latin America
His interests span many aspects of structural biology but principally the use of protein crystallography and homology modeling in the understanding of a wide range of biological phenomena at the molecular level
More social media
São Carlos research group develops simpler method for producing ultracold molecules
maintained at temperatures close to absolute zero (-273.15o C
involves many stages and requires the use of several laser beams
as well as equipment that costs millions of dollars and is only available in a few laboratories around the world
Luis Marcassa and his research team from the São Carlos Institute of Physics (IFSC) at the University of São Paulo (USP) recently developed a simpler way to create ultracold molecules—something physicists are interested in because they can be used to test the fundamental properties of particles
Using one laser beam and a set of equipment that cost just US$150,000
the USP group generated rubidium molecules at a temperature of 10 microKelvin (10 millionths of a degree above absolute zero)
The innovation is in how the molecules are cooled
experiments used a laser beam to slow down the molecules until they were almost at a standstill
This makes them lose energy and vibrate less (the less they vibrate
but other laser beams and techniques are needed to control molecular rotation
Marcassa and his team decided to try cooling them by taking advantage of one of the fundamental properties of all particles: the tendency to always expend the lowest possible amount of energy
they used a laser to energize the molecules
The molecules then release energy by emitting light
sometimes with even less energy than they started with
Based on calculations by Olivier Dulieu’s group from the University of Paris-Sud in France
the USP team repeated the procedure almost 20 times
progressively reducing the energy supplied to the particles until they almost stopped vibrating entirely
The strategy successfully lowered the temperature of 74% of the 10,000 rubidium molecules used in the experiment
according to an article published in Physical Review Letters in March
“The experiment functioned as proof of principle
I hope it encourages other groups to try to reproduce the results,” says Marcassa
“It is simpler than previous methods and an interesting alternative,” says physicist Marcio Miranda
from the Federal University of Pernambuco (UFPE)
who was involved in producing the first ultracold molecules in the USA in 2008
“Control over molecular rotation still needs to be improved.”
Project Manipulation of atomic collisions in optical traps (nº 13/02816-8); Grant Mechanism Thematic Project; Principal Investigator Luis Gustavo Marcassa (IFSC-USP); Investment R$1,487,738.55
Scientific article PASSAGEM, H. F. et al. Continuous loading of ultracold ground-state 85Rb2 molecules in a dipole trap using a single light beam
the supercomputer can be used not only by researchers at the center where it is installed but also by other researchers affiliated with other universities and research institutions throughout São Paulo State (photo: CeMEAI)
Euler high-performance science data processing system is the fastest-ever computer installed in a university in São Paulo State
By Elton Alisson in São Carlos | Agência FAPESP – A groundbreaking high-performance science data processing system called Euler was unveiled on July 14 at the São Carlos campus of the University of São Paulo (USP), in the interior of the state. The computer cluster belongs to the Center for Research, Innovation & Diffusion in Mathematical Sciences Applied to Industry (CeMEAI)
Innovation & Diffusion Centers (RIDCs) supported by FAPESP
Acquired at a cost of R$4.5 million (now about US$1.4 million)
Euler is the fastest computer system installed in São Paulo State’s universities
“The cluster was installed in January and went live in March
it’s been used by several researchers for projects that require high-performance computing,” said José Alberto Cuminato
a professor at the USP São Carlos Mathematical Sciences & Computing Institute (ICMC) and the director of CeMEAI
Named for the Swiss mathematician and physicist Leonhard Paul Euler (1707-83)
who contributed to scientific progress in several fields
applied mathematical analysis and fluid mechanics
the cluster consists of 104 computers linked to each other by a high-speed network
Each computer has two processors with 20 cores
Whereas an ordinary laptop computer can perform 10 billion basic mathematical operations (such as addition
multiplication and division) every second – known as floating-point operations per second
or flops – Euler is capable of 47 trillion flops
“Euler is suitable for applications that require parallel processing
such as simulating flows of oil or other fluids
and Big Data processing,” said Fabrício Simeoni de Sousa
a professor at ICMC and the staffer responsible for the computer cluster
Installed in a hosting room of the Information Technology Center (CETI) on USP’s São Carlos campus
Euler is already being used by researchers affiliated with universities and research institutions in São Paulo State
A group of researchers at ICMC is using the supercomputer for oil refining and combustion simulations in partnership with Petrobras
Another group of researchers affiliated with the Institute of Advanced Studies (IEA) at the Aerospace Technology General Command (CTA) has used Euler for aerodynamics simulations
the Brazilian suborbital mission scheduled to launch later this year
“An aerodynamics simulation used to take 150 days
we can process this kind of operation in 20 days
thanks to the supercomputer,” said Carlo Junqueira-Junior
Euler is funded by FAPESP’s Multi-User Equipment Program
so it can be used not just by researchers at CeMEAI but also by other researchers affiliated with universities and research institutions throughout São Paulo State
“FAPESP has funded several computer clusters at universities and research institutions in the state,” said Carlos Henrique de Brito Cruz
“The challenge for institutions that receive funding to acquire multi-user equipment is facilitating access for all interested researchers affiliated with the state’s universities and research institutions.”
CeMEAI’s computer cluster will be upgraded to increase the number of processors
The upgrade will make Euler the fastest supercomputer installed in any Brazilian university and possibly one of the top 500 supercomputers in operation worldwide
“The fastest computer system installed in a Brazilian university at present is the Rio de Janeiro Federal University’s High-Performance Computer Center [NACAD-UFRJ],” Sousa said
will be installed in September at the National Scientific Computing Laboratory (LNCC)
which is part of the National High-Performance Processing System (SINAPAD)
and will cost R$60 million (about US$18.8 million)
For more information about the Euler supercomputer, visit www.cemeai.icmc.usp.br
For more information about the Euler supercomputer, visit www.cemeai.icmc.usp.br.