Personal – Daughter of Peter and Nicole Sobral .. Graduated in top five percent of her high school class This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page The site owner may have set restrictions that prevent you from accessing the site I got an error when visiting eurovision.tv/video/ziferblat-amar-pelos-dois-salvador-sobral-cover-ukraine-eurovisionalbm The Eurovision 2025 season is now in full swing and no doubt fans will have the songs from this year’s contest on repeat until we crown a winner in May But that doesn’t mean we forget about the artists from past contests – they’re still bringing us a lot of new music to enjoy Contrary to the commonly perpetuated myth about the song contest killing careers we’re always thrilled to report that singers associated with Eurovision are thriving Here is our latest weekly roundup with a selection of the songs released recently by Eurovision stars With so many new songs this week, we’ve split the roundup into two smaller articles. You can find part 2 here. Lucio Corsi is competing in this year’s Eurovision Song Contest in Basel which happens to be International Poetry Day he dropped a new album — basically poetry set to music The album shares its name with his Eurovision song Volevo essere un duro (I Wanted to Be a Tough Guy) this album is the ultimate Italian indie experience — poetic and melancholic The album includes “Tu sei il mattino” (You’re the Morning) a track he had already released to huge success like “Nel cuore della notte” (In the Heart of the Night) while others will put a smile on your face Lucio also brings some wild characters to life in his songs: “Francis Delacroix” is about a little boy made of wood who claims he smoked with Buddha in Bob Dylan’s dressing room in Naples (and had plenty of other legendary adventures — not that he’s lying Then there’s “Let There Be Rocko,” which tells the story of a middle school bully I found nine different songs and convinced them to go and live in the same building […] It’s a record about childhood whether they are daisy meadows or squallid industrial areas In forms of expression I believe that the thing we should tend to is change In this disc I have looked for a transformation trying not to pull my feet off the ground any more I have been trying to sing clearly and directly about people.” VÆB are the siblings representing Iceland at Eurovision this year Even with the Eurovision season in full swing and pre-parties kicking off they still find time to entertain their fans with new music — this time an iconic Icelandic band that has been around since 1985 consistently releasing fun and entertaining music SPRNKLR is also part of this collaboration “brings the same high energy as VÆB’s Eurovision entry blending Icelandic pop and rap in a way that perfectly captures their style the rock band that won Eurovision for Italy in 2021 she’s dropping a collaboration with Tommy Genesis and Miss Bashful the music video itself is all about a girls-only party — one that The song dives into see-through t-shirts and wet t-shirt contests and the small ones win… if you know what we mean SAGES is a Swedish duo formed by Ólafur Arnalds and double Eurovision winner Loreen This collaboration is all about creating music that feels like a brand-new experience and this week’s track is no exception With a sensitive and graceful instrumental and Loreen’s voice connecting deeply to every emotion Emotive Pop — a style where euphoric This is already the third song from the newly formed duo and when asked about the connection between this one and their previous work “These 3 tracks are a cycle interwoven of ideas – First breathing then making conscious decisions and finally opening and growing into oneself.” the winner of Eurovision 2017 for Portugal has sung in many languages over the years — Portuguese His latest release is a jazzy collaboration with AVDYSH a contemporary Ukrainian music project led by singer Kateryna Avdysh The song is all about freedom — flying free like a bird and finding direction on a one-way journey: “Fly fly / This whole world is yours / The whole planet is your home now / You’re free you’re not in a trap.” It all comes together in the song’s closing lines: “Fly fly… / My home is now the whole planet.” Anouk represented the Netherlands at Eurovision in 2013 Her new song is a retro rock track with bold lyrics like “Where the mind goes / The girl will follow,” telling the story of a woman who leaves behind a toxic relationship in search of peace of mind The lyrics dive into the dysfunction of the relationship with lines like “I cheated on my cheater,” while also capturing the feeling of finally finding true love This track will be part of her upcoming album “Your Legacy,” she takes us through an open door straight to her heart The song is a deep confession about family and a heartfelt tribute to her father whose memory lives on forever in Rosa’s heart The track beautifully connects her late father to the family members still here with lyrics that are both powerful and heart-breaking: “You don’t know how difficult it is not to have you / You don’t know how much I still miss your way of understanding / You did something right because your memory lives on / Everyone talks to me… about you.” and this week he’s back with a pop banger that’s ready to take over the airwaves The song captures the moment of realisation that a relationship just isn’t working anymore: “I know what lovers do / We are so far away.” It goes on to say that changing direction is okay — sometimes even for the best — and that he’s done pretending: “Ain’t nothing wrong with changing your mind / But I won’t pretend we’ll be alright.” Trijntje represented the Netherlands in 2015 she teams up with Dutch singer and saxophonist Lo van Gorp for a collaboration The jazzy track is an ode to mothers and all they do in this world it’s one of those sensitive additions to our playlist this week Lord Of The Lost is a well-known rock band from Germany that competed in 2023 After recently participating in numerous collaborations with various artists LOTL are back with a song of their own — a rock anthem about finding sanctuary in your own darkness Despite the dark visuals and the song’s heavy sound the lyrics are all about finding your sanctuary where you can gather the strength to move forward Aminata remains an iconic Eurovision figure after her flawless representation for Latvia in 2015 “Regardless,” showcases her incredible voice once again in an acoustic tune about the passage of time and how some things remain lost and forgotten: “Let time pass until it flows like a boat / We’ll each sit in our own boat.” A bittersweet meditation on time Aminata once again captures a whole range of emotions in just one track is bringing us “In The Good Old Days” with his newest track With a retro intro that becomes a recurring motif throughout the song it ironically reflects on the challenges of the past comparing them to the challenges of the present day Monica represented Romania in 2002 alongside Marcel Pavel and now she’s back with a stunning new ballad With a delicate black-and-white music video and Monica’s powerful voice “Immunity to I Love You” will hit you deep in your soul if you’ve ever felt heartbroken The lyrics speak to the struggles of love and loss: “If silence is your favourite song / Let the kiss be our last dance / If our love is a battlefield / Who is the first of us raising the white flag?” As the song continues it explores how a painful romantic experience can make you immune to love leaving lasting marks on your heart: “Don’t tell me to be quiet I swear / It’s so unearthly to be immune to ‘I love you.'” winter.” He represented Croatia in 2017 The song is a celebration of love and a promise to go through all the seasons of life together even after the challenging winters of the soul The song is crafted for a slow dance for two Connect-R is a Romanian artist who represented Moldova at Eurovision in 2006 alongside Arsenium and Natalia his new song features a series of specific slang and expressions from the Romani language as the chorus says: “Tell me / With whom you’re with / When you’re not answering my phone.” She’s bringing us a retro dance track called “I’m Hurt.” The lyrics speak about a love that has been kept secret and how difficult it is to keep it that way: “I am so lost for you / I am lost / From missing you secretly every night / I am tired of keeping it a secret.” Which of these new songs is your favourite Do you have any artists you want to shout out to Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Δdocument.getElementById( "ak_js_2" ).setAttribute( "value" I liked Lucio Corsi with the quiet songs about the animals Sorry to be THAT Italian person who always question what you wrote but many things about Lucio Corsi’s songs are wrong “Sigarette” don’t put a smile on your face it’s the most unmerciful songs of all the songs he ever wrote in his entire career And Francis Delacrois is about a friend of him (a photographer) that has adventures are so crazy in real life that he decided to rewrite his story in a even crazier way with tons and tons of quotes to places The beginning when he said that is a wooden child is… Read more » Žvak Houdek is currently causing ruckus with another song he wrote for some guys known as Prima Band and ever so lovely miss Nives Celzijus…titled Je Overview Meet the team Press Write for us Input your search keywords and press Enter Fans of Frenchcomics and fantasy have reason to rejoice: Patrick Sobral's Les Légendaires saga, published by Éditions Delcourt, is about to make its cinema debut. Guillaume Ivernel, already known for his work on Chasseurs de dragons, is taking the reins of this animated film adaptation Les Légendaires - Le Film will appeal to both long-time fans and newcomers curious to discover this fantastic world Les Légendaires - Le Film will be shown in cinemas from January 28 But a terrible curse has turned them back into.. Shimy and Razzia unite their powers to defeat the sorcerer Darkhell and free their planet from eternal childhood.. With its action-packed and magical storyline, Les Légendaires - Le Film should appeal to a wide family audience especially children and teenagers who lovefantasy adventures Those who grew up with Patrick Sobral's cult comics will rediscover the universe they know while newcomers will be able to discover this saga that blends humor The film could evoke works like Trollhunters or The Five Legends, with its mix of fantasy and accessible humor. On the other hand, those who prefer darker, more mature animation, such as The Moving Castle or Arcane The adaptation of Les Légendaires has long been awaited by fans of the comics who has already worked on ambitious animated projects promises a faithful transposition of the design and graphic universe of Patrick Sobral's albums little information has been revealed about the voice cast but the project seems intent on respecting the spirit of the original work while making it accessible to the general public Les Légendaires - Le Film marks an important event for fans of French comics and animation With its rich universe and captivating story this feature-length film could appeal to a wide audience especially young viewers and fans of the saga It remains to be seen whether the adaptation will capture all the magic and emotion of the original work on the big screen This article is based on information available online; we have not yet viewed the film or series mentioned January 2026 cinema releases: Films and times near youIn January 2026, cinema makes a comeback with a varied selection of films to discover on the big screen. [Read more] Cinema: which film to see today, this Monday May 5, 2025?Not sure which film to see today? Well, we've got plenty of films to show near you. [Read more] This page may contain AI-assisted elements, more information here Refer your establishment, click herePromote your event, click here Retail technology news and views for omnichannel retailers until this point its Managing Director in Portugal will now be heading up operations in its home and biggest market of Spain A mechanical engineer from the Instituto Superior Técnico de Lisboa, Sobral joined Glovo in June 2022 as Director of Brands Ads at a global level he assumed the role of General Manager for Portugal the company is now experiencing one of the most exciting and challenging moments in its history leading the team in Spain is a unique opportunity My main challenges will be to continue to be the perfect digital ally for the 50,000 establishments that trust us in Spain and for users in the 900 Spanish cities where we are present to find everything they need," says Sobral who launched it in 2015 with Sacha Michaud following an initial round of funding the firm has been a part of the Delivery Hero Group Food delivery will be a key focus area at the 2025 RTIH Innovation Awards celebrate global tech innovation in a fast moving omnichannel world said: “The event is now into its sixth year and what a journey it has been The awards started life as an online only affair during the Covid outbreak before launching as a small scale in real life event and growing year on year to the point where we’re now selling out this fine He added: “Congratulations to all of our finalists Many submissions did not make it through to the final stage We’ve got all the cool stuff covered this evening.” “But just importantly we’ve got lots of great examples of companies taking innovative tech and making it usable in everyday operations - resulting in more efficiency and profitability in all areas.” and all those who attended November's gathering.  For further information on the 2025 RTIH Innovation Awards please fill in the below form and we will get back to you asap Sign up with your email address to receive the daily RTIH newsletter straight to your inbox We respect your privacy and will not pass your email address on to third parties we will occasionally send you promotional messages on behalf of our advertisers or transmitted in any form or by any means without the prior written permission of Paxton Media Ltd and Latin America at Blue Ant Media: We launched our FAST Channel Homeful on Pluto TV Blue Ant Media has been expanding its presence in Latin America “In the entire Latin American region our Love Nature channel in 4K (also in HD) is available in 22 countries on more than 70 platforms reaching 43 million homes,” said Julio Sobral Blue Ant Media’s reach includes some of the country’s major providers like Telecentro “allowing us to bring our content to millions of homes With a focus on both linear and VOD offerings we are committed to enhancing the viewing experience by continuously updating our content library and working closely with our platform partners Love Nature was the first 4K channel launched in Argentina by Telecentro and last year we collaborated with DIRECTV for a regional launch,” explained Sobral Sobral mentioned that they recently launched Blue Ant Media’s FAST Channel specializing in home renovation and real estate Sobral also mentioned that Love Nature is looking for natural history and wildlife producers in Latin America Love Nature launched two new series and documentaries filmed in Latin American regions such as Jaguar Journals with Lizzie Daly (filmed in Pantanal Brazil) and Wild Colombia (filmed in the Colombian jungle).” Sobral noted that many of Blue Ant Media’s partners in the region offer mobile and Internet services in addition to cable and satellite ensuring that the company’s content is accessible across various devices and platforms Blue Ant Media remains committed to delivering engaging and high-quality content through Love Nature and Homeful while exploring new opportunities to connect with audiences in Argentina and beyond,” he said de Sony Pictures Television para Latin America y US Hispanic habló sobre las claves del éxito de Yo no soy Mendoza serie que está en el top 10 global de Netflix narrada en 40 capítulos con una estructura moderna Quintanilla adelantó otras novedades de tres nuevas producciones VP sénior de Entretenimiento y Especiales de Telemundo el futuro del entretenimiento en español en EE yo creo que va a continuar evolucionando y va a continuar creciendo con muchísima fuerza porque somos una población de más de 66 millones de hispanos jóvenes que estamos viviendo y consumiendo contenido aquí en EE Amazon Prime Video está redefiniendo la experiencia del fan deportivo al integrar contenido premium tecnología interactiva y un ecosistema de servicios que abarca desde streaming y música hasta tiendas oficiales de equipos Country Manager de la plataforma en México destaca cómo estas estrategias permiten a Prime Video diferenciarse en un mercado altamente competitivo generando una conexión más profunda entre los aficionados y sus equipos favoritos al tiempo que amplifican el valor comercial del contenido deportivo 3C Films hizo su debut teatral con una producción de alto impacto: Sandro el gran show el primer musical oficial sobre la vida del ídolo argentino Estrenado el pasado jueves 10 de abril en el Teatro Coliseo de Buenos Aires el espectáculo es una coproducción de 3C Films y dirección musical de José Luis “Pepe” Pagán La empresa Tuves anunció la culminación exitosa de la migración de todos los usuarios de televisión satelital de Movistar en Venezuela al satélite con el que presta el servicio DTH a Inter desde 2013 El proceso duró dos años y marca el cierre definitivo del uso del satélite Amazonas 2 de Hispasat en ese servicio tras una transición técnica y comercial que se realizó “sin incidentes y con total transparencia para los clientes” El presidente de EE. UU., Donald Trump, anunció este domingo 4 a través de sus redes sociales Truth Social que autoriza al Departamento de Comercio y al Representante Comercial de EE a imponer un arancel del 100% a las películas producidas fuera de EE TelevisaUnivision y el canal tlnovelas anunciaron las novenas en cuanto al proceso de remasterización de contenido que arrancó en 2019 y a la fecha supera las 2 mil horas anuales y un total de 47 títulos finalizados es el más reciente producto remasterizado con ayuda de la IA Peacock anunció el lanzamiento de cuatro nuevas series originales lideradas por artistas emergentes desarrolladas y ejecutadas por creadores de la nueva generación: Charlie Curtis-Beard exitosas estrellas de las redes sociales con seguidores apasionados y negocios en crecimiento Kerrigan y Vongirdner colaboraron con NBCUniversal a través del Creator Accelerator Program una iniciativa pionera en la industria que identifica y desarrolla a la próxima generación de creadores de contenido premium Una nueva temporada de El gran chef famosos: Extremo llega a Latina Televisión de Perú y ya se dieron a conocer a los seis primeros participantes de los doce nuevos famosos que prometen darlo todo en la cocina PRODU sigue manteniendo a la industria informada con entrevistas exclusivas. Este lunes 5 llega una nueva edición de #PRODUprimetime con Ríchard Izarra desde Bogotá con Rodrigo Guerrero y Cristina Echeverri, directores de AG Studios. Blue Ant Media launches Love for the Earth Week to celebrate Earth Day Blue Ant Media: The audience is discovering linear channels through free streaming Blue Ant Media: We’re in discussions with two Latin American partners to co-produce Blue Ant Media: We have plans to launch other linear channels in Latin America Blue Ant Media: In the last year our Love Nature TV has reached 6.5 million households in LatAm Blue Ant Media: Introducing 270 new hours of factual content on MIPTV Usamos cookies para ofrecerte la mejor experiencia en nuestra web Puedes encontrar más información sobre qué cookies estamos usando o desactivarlas en los ajustes Esta web utiliza cookies para que podamos ofrecerte la mejor experiencia de usuario posible La información de las cookies se almacena en tu navegador y realiza funciones tales como reconocerte cuando vuelves a nuestra web o ayudar a nuestro equipo a comprender qué secciones de la web encuentras más interesantes y útiles Las cookies estrictamente necesarias tiene que activarse siempre para que podamos guardar tus preferencias de ajustes de cookies Si desactivas esta cookie no podremos guardar tus preferencias Esto significa que cada vez que visites esta web tendrás que activar o desactivar las cookies de nuevo Get our news on your inbox! Suscribe x MercoPress, en Español Montevideo, May 5th 2025 - 13:15 UTC Argentina's Defense Ministry Wednesday announced it was pulling the the decommisioned sloop ARA Alférez Sobral from a list of old units to be auctioned for scraps given the vessel's historic participation in the 1982 South Atlantic conflict over the Falkland Islands The decision was adopted by Minister Luis Petri himself The ship is now expected to be turned into a museum The auction of four units -including the Alférez Sobral- is scheduled for Sept The Argentine Navy fetched a minimum of AR$ 14.2 million (around US$ 11,000 at the unofficial exchange rate known as “blue,” a euphemism for “black market”) The sale for scraps of the other three decommissioned ships - two corvettes plus an hydrographic vessel - is to proceed as scheduled while the Sobral is to be handed over to the highest bidder for the development of a museum in a separate tender Institutions and private citizens interested in the project may submit their proposals until Dec parts of the ship such as the bell and a cannon are to undergo restoration.} the Sobral was rendered unusable after damage to her bridge and navigation systems from two British missiles fired from a helicopter The Sobral's captain Sergio Gómez Roca and seven other crewmembers were killed in action the 43.6-meter long and 10.3-meter wide vessel served as the USS Salish where in the Pacific Ocean theater before being delivered to the Argentine Navy in 1972 where she was name after Ensign José María Sobral a military explorer and geologist who stood out for his involvement in activities concerning Antarctica Commenting for this story is now closed.If you have a Facebook account, become a fan and comment on our Facebook Page Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Miles-Sterling Funeral & Tribute Center Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors with the tenderness and twang of a roadside tavern Toronto-based songwriter inspired by heart-worn country delivered with a spirituous temper and passion along the highways of the world The magical voice & guitar playing of Nelson Sobral channels soul blues and rock’n’roll into one transformative and cathartic late-night vision Nelson Sobral is a singer-songwriter-guitarist hailing from Toronto wide open spaces of the country he calls home and the labyrinthine maze of the city in which he resides Sobral’s music is as much Americana and blues as it is soul and rock’n’roll perfectly balanced with the energy and sound of each of his respective influences singular mission: to move and energize audiences into an all-night frenzy and travel the world on the might of his song and the means by which it is delivered transcends genre Though clearly inspired by the roots of songwriting giants—the Hank Williams and the Gram Parsons of the world—Sobral’s work deserves a wider scope paired with his incomparable voice and monster guitar playing 2 LPs and a bunch of singles with a 3rd LP out soon Sit with a guitar tinkering and doing vocal warmups for at least 5-10mins Former night owl now with kids early bird with a propensity for the night Road can be a bit more grueling and I have a pretty decent home studio I have my 3rd full-length coming out (date TBA). Check my website Linktree What is your favourite street in your city and why What is your favourite park in your city and why It has a great kids area where I hang out with my 2 boys What is your favourite music venue in your city What is your favourite music store in your city Moon Poker Offers Fast and Free Tournaments With a Cosmic Twist Star Wars Outlaws (PS5) Review: Boring Conversation Anyway Since the founding of the hip-hop genre in 1973, the genre has evolved into something more than just a party […] Name: Words LIke Wildfire -Ian Archer – Vocals -A.J. Chmilar – Bass/ Vocals -Avery Mocha – Drums -Cody Wood – […] As the warm embrace of summer settled upon the city, it only signified one thing for music lovers: Canadian Music […] A Toronto-centric online lifestyle magazine focusing on arts Students in the Brazilian municipality of Sobral have made remarkable progress in foundational learning, surpassing national trends. Systematic learning assessments and the accountability they foster are central to this success Let’s take a closer look at Sobral’s education reform student learning outcomes in Sobral lagged behind the national average through the right policy reforms and targeted interventions Sobral not only reversed this trend but also significantly accelerated learning even after adjusting for learning losses due to the COVID-19 pandemic Sobral's education reforms have become a model for other sub-national governments in Brazil, including its state, Ceará. The reform package in Ceará focused on financial incentives for municipalities to improve literacy outcomes in early primary grades technical assistance to municipal school networks to strengthen literacy instruction municipality autonomy and decentralized management of primary and lower secondary education and establishing monitoring systems to track education outcomes Students have benefited from these systemic reforms resulting in elevated standards of educational services conducive to their academic achievements Change in education quality index (IDEB) scores in grade 5 for Brazil Learning assessment results are also utilized to set learning targets for schools ensure accountability for continuous improvement and tailor in-service training for school leadership assessment results are used to provide financial incentives to high-performing teachers and schools allocate additional financial support for schools not reaching specific targets and hold officials from the municipal department of education accountable for poor performance How does Sobral's learning assessment system work Sobral employs various learning assessments to monitor learning progress for different purposes All schools use formative classroom assessments to continuously monitor student learning and coordinate with literacy and numeracy specialists to assist with remedial education for students in need Teachers are guided on how to use the results of classroom assessments to modify their instruction to meet students at their ability level and focus teaching on areas where students require support Teachers and students also receive materials and lesson plans that include activities to assess student understanding 2. Municipality-level large-scale assessments. Sobral conducts census-based assessments twice a year to inform about students' progress in foundational literacy and numeracy skills Schools and teachers receive a report with individualized information about each student's progress and additional guidance on expected learning targets to be reached by the end of the academic year Schools must act on these results to ensure students reach these targets census-based literacy and numeracy assessment Top-performing schools receive financial awards from the state government and those lagging also receive grants for improvement These assessments enable monitoring and comparing student learning progress over time which is important to inform whether Ceará and its municipalities show learning gains or losses from one assessment round to the next SAEB also allows for temporal comparability of results to monitor learning progress over time Learning assessment types in Sobral and their key differences Brazil participates in regional and international assessments and carries out high-stakes national exams.  These assessments also provide additional information about student learning outcomes.  High-stakes exams. The National High School Examination (ENEM) is used to monitor high-school learning admit students into federal public universities and provide an input for the higher education scholarship program Sobral also conducts an exam preparatory course open to all youth living in the city Leveraging assessment results for quality improvement and accountability Sobral places significant emphasis on learning assessments for continuous improvement and accountability utilizing the results to make informed decisions and promote activities aligned with the broader goals of the education system these assessment activities help Sobral set clear learning targets for the local education system guide the development and revision of teaching and learning materials inform the professional development needs of teachers and support remedial education and extracurricular activities for students who need additional assistance the case of Sobral demonstrates how effectively using assessment results can cultivate a culture of accountability within an education system and policymakers in Sobral are held to high standards to achieve specific learning targets and are supported when they fail to meet specific learning targets This accountability framework also includes rewarding teachers for outstanding performance by their students through bonuses and recognizing performing teachers through public events to make the teaching profession more attractive While other education systems may not directly replicate Sobral’s experience, one important lesson is to develop an assessment system that continuously monitors learning and uses data to improve student learning outcomes. Policymakers from other countries should also recognize the importance of tailoring assessment systems to their unique contexts to implement learning assessment activities effectively.  This blog was produced with support from the Foundational Learning Compact a World Bank multi-donor umbrella trust fund for early childhood To receive weekly articles, sign-up here Thank you for choosing to be part of the Education for Global Development community The latest blog posts and blog-related announcements will be delivered directly to your email inbox The policy response to the COVID-19 shocks to education needs to be comprehensive and well-planned to ensure that education systems are “built back better than before” Learning from successful experiences in education is key to help develop this response Many lessons on how to successfully fight learning poverty and improve foundational learning can be learned from Ceará - a relatively poor state in Northeastern Brazil with 9 million inhabitants - and Sobral - a 200-thousand-inhabitants municipality where 20 years ago 8 out of 10 kids were illiterate These lessons are even more important now that Brazil and the world will have to recover from the effects of the pandemic on learning outcomes and have an opportunity to deeply reform their education systems to accelerate learning.  As part of an effort to learn more about globally successful cases a team of education specialists from the World Bank visited Ceará and Sobral in early February We were a group formed by people of eight nationalities with the expectation of discovering a great secret to spread to the world vice-governor of Ceará who led the main educational reforms in the state as secretary of education and from Ivo Gomes who also led several of the main education reforms in that municipality we heard the same answer: There is no secret really! It boils down to a strong focus on the basics teaching children how to read by the right age and making everyone and the system to coherently work towards that goal Let us here tease out the main ingredients of their formula the facts: Learning improved much faster in Sobral had the biggest increase in education quality (as measured by Brazil’s Basic Education Development Index Almost all of the 184 Ceará municipalities initially had very low levels of quality in teaching and very limited resources investing about a third of the per student education spending of wealthier Brazilian states Ceará improved the quality of education so much faster than the rest of Brazil Sobral went from a bottom-ranked municipality to become first for both primary and lower secondary education and to reach  levels of education quality comparable with those of world-class education systems as measured by PISA Today Ceará has the lowest rates of learning poverty in Brazil and features 10 of the 20 top-ranked municipalities and Sobral has some of the best primary schools in Brazil the outstanding educational results of Ceará and Sobral students are well above what would be expected given the socioeconomic context in which they live and learn what are the key ingredients of the formula for the success in education of Ceará and Sobral what  municipal schools in Ceará have accomplished is firmly grounded in insights from the Science of Learning which emphasize three key principles: first opportunities and incentives to get better; and third that sustained performance improvement requires constant and focused feedback and then Ceará have embraced these principles in the day-to-day practices and interactions of students principals and even district officials in classrooms and schools these principles manifest in having a clear diagnostic of learning and system performance focusing the efforts on top priorities for improvement and then choosing the right set of strategies and implementing them in a coordinated and persistent fashion with all key education stakeholders.  the formula for education success of Ceará has five main ingredients which are supported by international evidence on what works in education The first three ingredients involve sound financing and pedagogical policies for municipalities to achieve better education outcomes; (ii) technical support to the municipal school networks struggling to improve learning goals with a strong focus on enhancing teacher effectiveness and achieving universal literacy at the right age; and (iii) the use of a robust and reliable monitoring and assessment system which continuously assesses key results of education These three ingredients emphasize instructional coherence in terms of the alignment of the curriculum (what students are expected to learn) teachers’ pedagogical approaches (how students are taught) and learning assessment (how the system checks whether students are learning) They also show consistent implementation over time building on earlier preparatory reforms.  The fourth ingredient is a high degree of autonomy for municipalities to design and implement their education policies this leads to the creation of a culture where feedback is essential to improve performance throughout the system What stroke us the most in visiting Ceará and Sobral is that when asked about the potential drawbacks of the use of assessments and incentives to drive performance and administrators generally reframed the conversation: they see feedback and incentives as critical to achieve learning for all rather than as instruments of accountability ingredient that makes it all stick together and enables action is a sustained political leadership and commitment to education quality Recipe for success in education in the state of Ceará   No other municipality exemplifies this non-miraculous recipe better than Sobral What has led Sobral to become the best education system in Brazil is the coherent mix of:  (i) Effective and continuous use of student assessment through written and oral evaluations of all children focused on reading fluency and using learning outcomes extensively to guide education policy and in-classroom pedagogical practices; (ii) Focused and well-aligned curriculum with a clear learning sequence and prioritization of foundational skills as well as its full alignment with national textbooks and teacher training; (iii) Prepared and motivated teachers with focused and practical professional development Recipe for success in learning in the city of Sobral   All of the successful education policy reforms in Ceará and Sobral involved a crucial first step: political leadership and a commitment to put learning first or as a high-level official put it “to take politics outside of schools”  Strong political leadership is needed to confront the resistance from stakeholders whose interests are not always well-aligned with student learning Again in Sobral sustained and strong political leadership has placed education as a top priority as made explicit by a sharp overarching goal: ensure that all students are fully literate by grade 2.  Countries that are firmly committed to achieving learning for all can well start with establishing similar time-bound ambitious targets to eliminate learning poverty and adapt the key ingredients of the success formula of Ceará and Sobral to their own country contexts To learn more about what worked in Ceará and in Sobral, check out our webpage with a variety of resources on both experiences Ceará has experienced the largest increase in the national education quality index in both primary and lower secondary education since 2005 Photo by Mariana Kaipper Ceratti/World Bank Policymakers around the world can learn valuable lessons on how to successfully fight learning poverty and improve foundational learning from the relatively poor Brazilian state of Ceará (with its 9 million inhabitants) and Sobral a municipality in Ceará with 200,000 inhabitants Both Ceará and Sobral had low levels of literacy 20 years ago and went on to improve the quality of their education systems much faster than the rest of the country achieving levels of education quality comparable with the most developed countries “The State of Ceara in Brazil is a Role Model for Reducing Learning Poverty” presents the key education reforms implemented in the state that led to substantial improvements in quality in primary and lower secondary education Despite having the 5th lowest GDP per capita among the 26 Brazilian states Ten of its municipalities are now among the nation’s top 20 “Achieving World-Class Education in Adverse Socioeconomic Conditions: The Case of Sobral in Brazil” analyzes the main aspects of the reforms carried out by Sobral that led to rapid improvements on education quality Sobral did not even rank in the top thousand among Brazil’s municipalities it ranked first for both primary and lower secondary education in the national index of education quality The improvements in education in both the state of Ceará and the municipality of Sobral are the result of a comprehensive package of education reforms In a time when the reformulation of the educational system is necessary due to the impact of the Covid-19 pandemic the education models in Ceará and Sobral can provide an example to all countries that wish to build back better than before their educational systems by aiming to eradicate learning poverty and build human capital An executive summary of both reports can be found here (15 pages) and a micro-summary of the two reports is here (2 pages). STAY CURRENT WITH OUR LATEST DATA & INSIGHTS © 2025 World Bank Group. All Rights Reserved. Volume 11 - 2023 | https://doi.org/10.3389/fchem.2023.1066280 This article is part of the Research TopicDiscovery of Novel Small Molecules to Combat CancerView all 6 articles Cancer is a leading cause of mortality responsible for an estimated 10 million deaths worldwide in 2020 and its incidence has been rapidly growing over the last decades as well as high systemic toxicity and chemoresistance associated with conventional anticancer therapies reflect these high levels of incidence and mortality efforts have been made to search for novel anticancer drugs with fewer side effects and greater therapeutic effectiveness Nature continues to be the main source of biologically active lead compounds and diterpenoids are considered one of the most important families since many have been reported to possess anticancer properties Oridonin is an ent-kaurane tetracyclic diterpenoid isolated from Rabdosia rubescens and has been a target of extensive research over the last few years It displays a broad range of biological effects including neuroprotective and anticancer activity against a variety of tumor cells Several structural modifications on the oridonin and biological evaluation of its derivatives have been performed creating a library of compounds with improved pharmacological activities This mini-review aims to highlight the recent advances in oridonin derivatives as potential anticancer drugs while succinctly exploring their proposed mechanisms of action future research perspectives in this field are also disclosed There is no curative treatment option available for cancer, and current anticancer therapies, especially chemotherapy, have limited therapeutic potential associated with adverse side effects, chemoresistance, and high systemic toxicity to the patient (Kashyap et al., 2021) studies have been performed to search for more efficient and selective anticancer drugs with greater therapeutic properties and better safety profiles there has been a growing attention toward the development of natural anticancer agents they continue to hold great potential in the search for novel lead compounds in drug discovery Herein we seek to briefly overview the biological activities of oridonin and highlight the emerging therapeutic potential of recent oridonin derivatives in anticancer therapy while also exploring their proposed mechanisms of action we provide a discussion of future research perspectives for the development of these derivatives in the clinic Oridonin (C20H28O6, compound 1 listed in Table 1) is an ent-kaurane tetracyclic diterpenoid isolated from the traditional Chinese medicinal herb Rabdosia rubescens. It was first reported in 1967 (Fujita et al., 1967), and the relationship between its anticancer activity and its structure was demonstrated a few years later (Fujita et al., 1976) Recent approaches of oridonin optimizations (modifications of hydroxyl groups) and 357 research articles published as of September 2022 while searching “oridonin AND cancer” This indicates that a major focus is being given to its anticancer activity Nevertheless, oridonin’s anticancer mechanisms of action are not yet fully understood. The suggested main ones include the suppression of the cell cycle progression, induction of apoptosis, and autophagy, by modulation of signaling pathways, for instance, regulation of intracellular reactive oxygen species (ROS), Bax/Bcl-2, p53/p21, NF-κB, MAPK, PI3K, and fatty acid synthase pathways (Ding et al., 2016) The relevant signaling pathways modulated by oridonin are represented in Figure 1 Schematic representation of the relevant signaling pathways modulated by oridonin Moreover, oridonin induced apoptosis in OCM-1 and MUM2B uveal melanoma cells (Gu et al., 2015), and SW480 and SW620 colorectal cancer cells (Kwan et al., 2013), by suppressing fatty acid synthase. In HepG2 cells, oridonin induced G2/M phase arrest and apoptosis via MAPK and p53 pathways (Wang et al., 2010) Furthermore, oridonin also induced autophagy by inhibiting glucose metabolism in colorectal cancer cells (Yao et al., 2017), and recent studies suggest that oridonin not only can suppress cell migration and invasion, (Li et al., 2016c), but also revert drug resistance (Kadioglu et al., 2018) Oridonin is recognized as a logical hit compound for anticancer therapy research. It has an appropriate molecular weight (364.4 g/mol) and plenty of functional groups that provide numerous synthetic routes to create different libraries of derivatives. Oridonin also meets the criteria of Lipinski’s rule (Lipinski et al., 2001) and it is relatively commercially available (Ding et al., 2016) Evidence shows that structural modifications on oridonin usually encompass four typical optimizations, as represented in Figure 2: 1) modifications of hydroxyl groups; 2) modifications of A-ring; 3) modifications of D-ring (α, β-unsaturated ketone); and 4) transformations of the skeletal structure (Zhang et al., 2020; Guan et al., 2021) Although this research has been active for a few years and substantial progress has been achieved in the identification of novel derivatives herein we have selected the most representative work Typical optimization sites and molecular structure of oridonin In the same year, Hou et al. synthesized novel C14-1,2,3-triazole oridonin derivatives via copper-catalyzed alkyne-azide cycloaddition (CuAAC). Compound 6 (listed in Table 1) proved to be the most potent (IC50 = 3.1 μM) against the PC-3 cancer cell line. Preliminary mechanistic studies reported that this compound caused G2/M phase arrest and induced apoptosis in a dose-dependent manner in the same cell line (Hou et al., 2019) The same research group also synthesized oridonin-coupled nitrogen mustard derivatives, and all of them showed better anticancer activity than oridonin against a variety of cell lines. Compound 9 (listed in Table 1) proved to be the most potent, exhibiting an IC50 value of 0.50 μM against the BEL-7402 cell line. This compound also induced apoptosis of BEL-7402 cells and caused G1 phase arrest (Xu et al., 2014) In 2020, Li and collaborators synthesized oridonin derivatives with H2S-releasing groups. Compound 10 (listed in Table 1) showed the most potent anticancer activity against the K562 cell line, with an IC50 value of 0.95 μM. Further studies revealed that compound 10 caused S phase arrest in K562 cells and G1 phase arrest in HepG2 cells (Li et al., 2020) The reported structural modifications generally improve the solubility of the derivatives by introducing aqueous solubility-enhancing moieties via esterification of the 1-O and 14-O-hydroxyl groups. Such derivatives usually act as prodrugs since ester bonds suffer from poor in vivo metabolic stability (Ding et al., 2013a) Recent approaches of oridonin optimizations (modifications of A-ring) In 2013, Ding et al. (2013a) developed novel derivatives by introducing a thiazole ring at C1 and C2 of oridonin’s A-ring. Most of the nitrogen-enriched derivatives exhibited higher potency and aqueous solubility. In the form of its HCl salt, compound 13 (listed in Table 2) exhibited approximately 62-fold improvement in aqueous solubility when compared with oridonin (1.29 mg/mL) compound 13 showed an IC50 value of 0.20 μM approximately 147-fold more potent than oridonin and mediated apoptosis of MDA-MB-231 cells α, β-unsaturated ketones (enones) are well-known Michael acceptors. For this reason, the enone system is considered an important pharmacophore of natural products, and oridonin’s D-ring enone appears to be critical for its anticancer activity (Ding et al., 2013b) few modifications have been performed on that part of the molecule that have successfully produced derivatives with improved activity Nonetheless, Shen et al. (2018) demonstrated that α, β-unsaturated ketones can be targets for structural modifications to achieve promising derivatives. Shen’s group synthesized oridonin derivatives with substituted benzene moieties at the C17 position, and compound 16 (listed in Table 3) proved to be the most potent with an IC50 value of 1.05 μM against the HCT-116 cell line compound 16 induced apoptosis and caused G2 phase arrest in HCT-116 cells Recent approaches of oridonin optimizations (modifications of D-ring - α Li et al. (2013a) synthesized ent-6,7-seco-oridonin derivatives by the conversion of oridonin to spirolactone-type diterpenoids. All the synthesized compounds exhibited better anticancer activity than oridonin, in vitro. Compound 17 (listed in Table 4) exhibited IC50 values of 0.39 μM against the K562 cell line and 1.39 μM against the BEL-7402 cell line similar values to that of the positive control Taxol (IC50 values of 0.41 μM and 1.89 μM Further mechanistic studies of compound 17 revealed that it induced apoptosis in BEL-7402 cells and caused G2/M phase arrest Recent approaches of oridonin optimizations (transformations of the skeletal structure) The global cancer burden is expected to be 28.4 million cases in 2040, corresponding to a 47% rise from 2020 (Sung et al., 2021) Chemotherapy continues to be the main therapeutic option for cancer treatment and oridonin has recently emerged as a promising hit compound due to its anticancer activity and the exact mechanisms of action remain to be further elucidated these findings lead us to believe that oridonin and its derivatives have tremendous potential yet to be discovered in a variety of cancers Although no oridonin-based drugs have been approved for clinical use by the U.S. Food and Drug Administration (FDA) or by the European Medicines Agency (EMA) (Liu et al., 2021b) compound HAO472 has already advanced into a phase I clinical trial in China and we anticipate that new oridonin derivatives may emerge as anticancer drug candidates and enter additional clinical trials soon It is imperative for oridonin and its derivatives to be the subjects of more robust pre-clinical studies to ensure the safety and potency of the compounds before developing them as anticancer drugs Further investigations are required regarding the single or combined use of oridonin and its derivatives in anticancer therapy while also exploring their role as anti-chemoresistance agents for they have the potential to be viable therapeutic options PS drafted the work and wrote the manuscript AV assisted in making the figures and tables All authors approved the manuscript in its final form for publication PS thanks the Portuguese Research Agency FCT—Fundação para a Ciência e a Tecnologia Figure 1 was created with BioRender.com The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 1https://pubmed.ncbi.nlm.nih.gov/ 2http://www.chinadrugtrials.org.cn/index.html Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis PubMed Abstract | CrossRef Full Text | Google Scholar The ever-increasing importance of cancer as a leading cause of premature death worldwide PubMed Abstract | CrossRef Full Text | Google Scholar Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin inhibits hypoxia-induced epithelial–mesenchymal transition and cell migration by the hypoxia-inducible factor-1α/matrix metallopeptidase-9 signal pathway in gallbladder cancer PubMed Abstract | CrossRef Full Text | Google Scholar Protective effects of oridonin on intestinal epithelial cells by suppressing tnfα-induced inflammation and epithelial-mesenchymal transition CrossRef Full Text | Google Scholar ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels–Alder reactions: synthesis of dihydropyran-fused diterpenoids PubMed Abstract | CrossRef Full Text | Google Scholar Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: Protecting group-free synthesis PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin ring A-based diverse constructions of enone functionality: Identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis PubMed Abstract | CrossRef Full Text | Google Scholar Discovery and development of natural product oridonin-inspired anticancer agents PubMed Abstract | CrossRef Full Text | Google Scholar The inhibitive effects of oridonin on cisplatin-resistant ovarian cancer cells via inducing cell apoptosis and inhibiting ADAM17 CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Antitumor activity of the isodon diterpenoids: Structural requirements for the activity PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase PubMed Abstract | CrossRef Full Text | Google Scholar Recent progress of oridonin and its derivatives for cancer therapy and drug resistance CrossRef Full Text | Google Scholar Oridonin suppresses transplant rejection by depleting T cells from the periphery PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces apoptosis and reverses drug resistance in cisplatin resistant human gastric cancer cells PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin improves the sensitivity of multiple myeloma cells to bortezomib through the PTEN/PI3K/akt pathway CrossRef Full Text | Google Scholar Synthesis of oridonin derivatives via mizoroki-heck reaction and click chemistry for cytotoxic activity PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin targets multiple drug-resistant tumor cells as determined by in silico and in vitro analyses PubMed Abstract | CrossRef Full Text | Google Scholar Natural product-based nanoformulations for cancer therapy: Opportunities and challenges PubMed Abstract | CrossRef Full Text | Google Scholar The value of pyrans as anticancer scaffolds in medicinal chemistry CrossRef Full Text | Google Scholar The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl-2 PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin inhibits VEGF-A-associated angiogenesis and epithelial-mesenchymal transition of breast cancer in vitro and in vivo PubMed Abstract | CrossRef Full Text | Google Scholar Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells PubMed Abstract | CrossRef Full Text | Google Scholar a promising ent-kaurane diterpenoid lead compound PubMed Abstract | CrossRef Full Text | Google Scholar Antitumor and antibacterial derivatives of oridonin: A main composition of dong-ling-cao PubMed Abstract | CrossRef Full Text | Google Scholar Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation PubMed Abstract | CrossRef Full Text | Google Scholar Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways PubMed Abstract | CrossRef Full Text | Google Scholar Synergistic antitumor activity of oridonin and valproic acid on HL-60 leukemia cells PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin suppress cell migration via regulation of nonmuscle myosin IIA PubMed Abstract | CrossRef Full Text | Google Scholar protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury PubMed Abstract | CrossRef Full Text | Google Scholar Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings PubMed Abstract | CrossRef Full Text | Google Scholar Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin enhances the anti-tumor activity of gemcitabine towards pancreatic cancer by stimulating Bax- and Smac-dependent apoptosis PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin inhibits epithelial-mesenchymal transition of human nasopharyngeal carcinoma cells by negatively regulating AKT/STAT3 signaling pathway PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells PubMed Abstract | CrossRef Full Text | Google Scholar Natural products as modulators of sirtuins PubMed Abstract | CrossRef Full Text | Google Scholar Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019 PubMed Abstract | CrossRef Full Text | Google Scholar and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway PubMed Abstract | CrossRef Full Text | Google Scholar Design and synthesis of novel oridonin analogues as potent anticancer agents PubMed Abstract | CrossRef Full Text | Google Scholar L-alanine-(14-oridonin) ester trifluoroacetate as well as preparation method and application thereof Google Scholar Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries PubMed Abstract | CrossRef Full Text | Google Scholar Amino acids as promoieties in prodrug design and development PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells PubMed Abstract | CrossRef Full Text | Google Scholar The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents PubMed Abstract | CrossRef Full Text | Google Scholar Synthesis and anti-tumor activity of 14-O-derivatives of natural oridonin CrossRef Full Text | Google Scholar Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection PubMed Abstract | CrossRef Full Text | Google Scholar Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates PubMed Abstract | CrossRef Full Text | Google Scholar Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma PubMed Abstract | CrossRef Full Text | Google Scholar Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates PubMed Abstract | CrossRef Full Text | Google Scholar Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design biological evaluation and nitric oxide release studies PubMed Abstract | CrossRef Full Text | Google Scholar A novel potent anticancer compound optimized from a natural oridonin scaffold induces apoptosis and cell cycle arrest through the mitochondrial pathway PubMed Abstract | CrossRef Full Text | Google Scholar Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2AX PubMed Abstract | CrossRef Full Text | Google Scholar Identification of a potent oridonin analogue for treatment of triple-negative breast cancer PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin alleviates visceral hyperalgesia in a rat model of postinflammatory irritable bowel syndrome: Role of colonic enterochromaffin cell and serotonin availability PubMed Abstract | CrossRef Full Text | Google Scholar Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia PubMed Abstract | CrossRef Full Text | Google Scholar ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells PubMed Abstract | CrossRef Full Text | Google Scholar Solubility and bioavailability enhancement of oridonin: A review PubMed Abstract | CrossRef Full Text | Google Scholar Protective effects of oridonin on the sepsis in mice PubMed Abstract | CrossRef Full Text | Google Scholar Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation PubMed Abstract | CrossRef Full Text | Google Scholar Vicente ATS and Salvador JAR (2023) Recent advances in oridonin derivatives with anticancer activity Received: 10 October 2022; Accepted: 26 January 2023;Published: 09 February 2023 Copyright © 2023 Sobral, Vicente and Salvador. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Jorge A. R. Salvador, c2FsdmFkb3JAY2kudWMucHQ= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish The children of Sobral have overcome disadvantage to top 5,000 districts Now their success is being replicated across the country headteacher of an early-years school in a low-income neighbourhood controlled by a gang Some of her students wouldn’t eat if it were not for free school meals Farias and her colleagues often hear stories of home life; some children have to accompany their mothers who sell sex at night “It’s a challenge but it motivates me to be here every day We want to make a difference in their lives,” she says Thank you for your feedback.</iframe>","caption":"Sign up here for a digest of uplifting tales like this emailed to your inbox every Friday For free!","isTracking":false,"isMainMedia":false,"source":"The Guardian","sourceDomain":"theguardian.com"}">Sign up here for a digest of uplifting tales like this emailed to your inbox every Friday For free!This is one of the last places anyone would expect would be a paragon of educational excellence Sobral has gone through an extraordinary metamorphosis and is now the best place in Brazil to get a state education The city comes top of 5,000 districts in Brazil’s education development index. Fifteen years ago, it was ranked 1,366th. Since 2015, literacy rates have risen from 52% to 92%, and the number of families living in extreme poverty has declined by 89% This is a stunning turnaround in a country beset by income inequality and poor literacy rates: half of state-educated students are still illiterate by the third grade So what has been Sobral’s secret to success says: “We have reached this position because this is a 23-year-old project that has surpassed changes in mayors and secretaries of education It is persistence and a lot of hard work.” the movement to improve education in Sobral began with renovating school buildings and furnishing them with computers and other resources politicians had commonly rewarded allies by handing out government jobs including headteacher posts to people who could barely read or write Literacy rates in the city have improved since 2015 from 52% to 92% Photograph: Educação de SobralThere was a crackdown on truancy; today families are called if their children don’t turn up to school Newly qualified teachers now undergo a preparatory internship and all teachers receive on-the-job training for a day each month Every term there is a bonus system for teachers whose students perform well in assessments Student welfare is a high priority; pupils receive two free school meals a day and there are plans to hire a mental health professional in each school All this has led in part to the success of former students such as Chelton Santos, 22, and his sister Maria, 20. The siblings live with their parents and grandmother in a poor and dangerous area. The family have survived on one minimum wage (now $258 a month) for many years “I grew up seeing gang fights,” said Chelton Santos My parents took good care of us but we had financial difficulties Student welfare is a high priority is Sobral’s education system Photograph: Educação de SobralDespite a difficult upbringing for the pair the future is looking bright: Santos is studying law at university and his sister is working as an office clerk to save money to study medicine I’ve seen my mother suffer with health problems since I was a child and now I want to help the poorest in society.” is hopeful about her children’s future: “I never believed that one day my son would be studying to be a lawyer at university We did everything we could to keep [the children] in school I wanted to give them a nicer place to live … it’s dangerous here they’re going to move from here to a better life.” Sobral’s success is now being replicated across the country. Clodoveu Arruda, a former mayor of the city, who oversaw a large part of the transformation in the education department, has teamed up with the Lemann Foundation to spread best practice So far they have worked in 25 municipalities across five states Not everyone in Sobral is content with what has been achieved however – they are hungry for further success says: “Being the top in Brazil doesn’t mean much if you look at the rest of the world Brazil is not very well positioned in the [international educational] Pisa rankings … This is what we are running after now.” The Lemann Foundation and Republica.org assisted with travel for the Guardian This article is part of a series on possible solutions to some of the world’s most stubborn problems Renato Sobral has competed as a mixed martial arts fighter for 16 years facing some of the best in the world for promotions like the UFC In a long interview with Brazilian outlet PVT the former Strikeforce light heavyweight champion and UFC title contender opened up on the health issues he’s dealing with after competing 48 times inside cages and rings Sobral was on the receiving end of knockouts seven times over 11 defeats Sobral says he has symptoms of chronic traumatic encephalopathy (CTE) ”What happened to me was something that came in homeopathic doses,” Sobral said but he doesn’t learn too much about how to manage his life about what I could have done with my career when I’m in a jiu-jitsu tournament or in training But the guys that start fighting have to know that the price to pay will come one day People only talk about the good things today ”If someone asked me if I would let my son fight vale tudo My daughter already is on the water polo ‘A’ team of her high school Any sport demands a lot from your body and you will have to pay the price in the future.” Sobral has been training capoeira lately to improve his balance but health concerns weren’t so common back in the old vale tudo days with bills to pay and a family to support “You start doing things you are not prepared to do I don’t know if I’ll be able to see my grandkids because I’m starting to slowly feel the effects.” “I already have [chronic] traumatic encephalopathy People barely talk about it,” he continued [professional fighters] have peaks of depression I have 13 surgeries through my entire body Please enable JS and disable any ad blocker NORTH KINGSTOWN – You could easily drive past Alpha & Omega Deaf Church without noticing it The congregants meet in a nondescript red brick building that used to be a physical therapist’s office The only hint of its presence is a modest sign with its name and address: 7291 Post Road But the church’s quiet demeanor on the outside belies its lively interior. On a recent Sunday, the fellowship room was abuzz with energy. Hands performing American Sign Language gestured warm greetings and made quick jokes Perhaps no presence loomed larger than Pastor Seth Sobral broad-shouldered and with an inviting smile he exuded a magnetic force that drew people to him Sobral brings this charisma to his sermons While preaching about Samson – a Bible character known for his supernatural strength – he joked about his physique While speaking during a service at other churches would be considered rude congregants sign back at him in the middle of his sermons The whole affair does not bother Sobral – he seems to harness the feedback back into his sermon “I should not be afraid,” Sobral signed during his sermon on Samson but that did not stop him from hearing God’s calling It started with a cartoon Bible when he was a kid and with his mother’s instruction He went to a hearing church but found it unrelatable “It's hard to really relate to the hearing world even though I'm looking for God's word,” Sobral said through an interpreter but Sobral said attendance dips during the summer While some churches offer ASL interpretation for services Alpha & Omega Deaf Church is the only deaf-owned Sobral estimated the nearest one would be in New York City or St Rhode Island’s deaf community is small. Only 6% of people 18 or older in the state have a hearing disability, according to the federal Centers for Disease Control and Prevention making the church an oasis for deaf people who are looking for a community of faith to join Some commute to Sunday services and mid-week Bible studies from Connecticut and Massachusetts The services are conducted entirely in ASL Sobral uses visual aids to help congregants follow along uses booming bass so everyone can feel the beat “We just want to try to connect to something greater or connect with something deeper and worship beyond our day-to-day life,” Sobral said The church attracts a wide range of people from the deaf community while others lost their hearing through an illness who was born in Puerto Rico and lives in Cumberland did not know ASL when her son lost his hearing at 3 years of age “It was a really tough challenge because I didn’t speak English so I had to learn English first and then ASL,” Medina said Medina now works with the Rhode Island Department of Health to help families with children who are deaf She said her favorite part of Alpha & Omega Church is the fellowship that she and her family have found finding the church itself was a spiritual experience who has been a congregant for about 10 years “God showed me the way and said go in this direction,” Buchanan said someone pointed her to Alpha & Omega Deaf Church Buchanan had previously attended a hearing church “There’s a lot of spoken language in the hearing world But now I can understand clearly,” Buchanan said who lost his hearing due to spinal meningitis when he was 14 months old also attended a hearing church without an interpreter It was hard to socialize or learn anything in that environment “I really have fallen in love with this church and learning more and more about God’s word,” Geisser said Sobral’s desire is that people understand that a deaf church is not so different from a hearing church Alpha & Omega Deaf Church may be the only place where they can step into a fully immersive ASL community It is not unusual for several to arrive early or stay behind for hours after the service just to spend time chatting with others in ASL Their time spent together in reverence of something much larger than self becomes all the richer for the rarity of their unity for the way they hunger for conversation and are nourished by each other's presence for the way they linger because they can relate so easily in the church they have made their joyful and liberating haven a baking-hot north-eastern state that has one of Brazil’s highest rates of poverty When local officials ordered tests in 2001 they found that 40% of Sobral’s eight-year-olds could not read at all One-third of primary pupils had been held back for at least a year He remembers a head teacher who signed documents with a thumbprint because she lacked the confidence even to scribble her own name This article appeared in the The Americas section of the print edition under the headline “Studying Ceará” Discover stories from this section and more in the list of contents Just as in the United States, working-class and immigrant voters swung right The Conservatives suffered one of the most astonishing falls from popularity in political history An interview with Evo Morales in his tropical highland stronghold MAGA bombast has upended Canada’s political universe and given Mark Carney’s Liberals an edge Donald Trump and Justin Trudeau’s toxic legacy have pushed Canadians to the centre Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInTRUMBULL COUNTY OH (WOIO) - Brazil native Claudia Hoerig (Sobral) was married to Major Karl Hoerig for two years before she murdered him in Newton Falls on March 12 Police reportedly discovered the decorated Air Force and commercial airline pilot in his home with multiple gunshot wounds to his back and head The Trumbull County prosecutor said Claudia Hoerig fled to Brazil the day of her husband’s death and had a warrant out for aggravated murder for 10 years An extradition treaty between the United States and Brazil finally returned Claudia Hoerig to Trumbull County in January of 2018 Claudia Hoerig’s trial in January of 2019 was delayed after she complained of a heart issue and was taken to a hospital to be examined as a precaution Judge Andrew Logan took the prosecutor’s recommendation and sentenced Claudia Hoerig on Friday to life in prison with parole eligibility after 28 years Portugal (AP) - Eurovision Song Contest winner Salvador Sobral has left a Portuguese hospital after a successful heart transplant The Santa Cruz Hospital near Lisbon says the 28-year-old Portuguese singer made a "very satisfactory" recovery from the transplant he underwent in December But the hospital statement on Friday says Sobral's activities will be limited for the time being Sobral sang a solo ballad in last year's Eurovision competition to give Portugal its first win in 53 years of competing He was welcomed as a national hero after the win His modest attitude and insistence on presenting music without frills have won him many fans Portugal will host the Eurovision Song Contest for the first time this year Salvador Sobral of Portugal smiles as he speaks at a news conference on Saturday after winning the Eurovision Song Contest with his song "Amar Pelos Dois" in Kiev this year's winner of the Eurovision Song Contest Most of the performances are noted for a lot of glitz and being pretty cheesy Twenty-five competitors carried on that tradition this year — performing on a wide stage backed by flashing lights Sobral took a different take in his performance on Saturday — singing from a small elevated circle in the middle of the crowd His song "Amar Pelos Dois" — "Love For Both" — struck an intimate chord with the audience Kristian Kostov of Bulgaria was runner-up and Moldova's Sunstroke Project finished third This is the 62nd year for Eurovision which was started to bring recently warring European countries together "Russia's participation was scuttled by host Ukraine over the two nations' diplomatic and military conflict "Russia is one of Eurovision's heavy hitters tied with Sweden for the most top-five finishes this century was blocked from competing by Ukraine because she had toured in Crimea after Russia's 2014 annexation of the peninsula Russia's state-owned Channel 1 television is refusing to broadcast the contest replacing Saturday's final with a screening of the film "Alien." "The Moscow-Kiev split is a headache for Eurovision's producer which strives mightily to keep pop and politics separate Overtly political flags and banners are banned and lyrics are monitored for provocative content the EBU nixed the Georgian entry "We Don't Wanna Put In," a dig at Russian President Vladimir Putin has been criticized for not barring "1944" last year allowing Russia-Ukraine tensions to fester." and it has helped to boost the careers of many performers — including Sweden's ABBA which won in 1974 with the song "Waterloo." Become an NPR sponsor National Observatory restores 61 photographic plates taken in Sobral of the 1919 solar eclipse, which proved the assumptions of the general theory of relativity National Observatory Astronomer Teófilo H. Lee (above), member of the Brazilian team in Sobral, made spectroscopic observations of the Sun’s coronaNational Observatory National Observatory Scientists on the expeditions came from Rio de Janeiro (standing) and London (seated)…National Observatory In an article published several days prior to the event in a local newspaper, astronomer Henrique Charles Morize, then-director of the National Observatory, had requested that people viewing the eclipse do so in silence, refraining from shooting off fireworks in order not to interfere with the observation of the eclipse and compromise the quality of the photographs taken. National Observatory …to observe and record the 1919 total solar eclipse (above) in SobralNational Observatory National Observatory Astronomer Henrique Charles Morize, then-director of the National Observatory and head of the Brazilian team in SobralNational Observatory National Observatory Astrographic refracting telescope used to record images of the total solar eclipse on photographic platesNational Observatory National Observatory Image of the Moon’s disk covering the Sun recorded on one of the photographic platesNational Observatory Confirmation of Einstein’s theory came months later astronomers at the Royal Astronomical Society in London concluded that the general theory of relativity was correct after analyzing the results obtained from the photographic plates created in Sobral and Principe The final result of the observations made at Principe demonstrated an average deviation of 1.6 arcseconds while the data gathered at Sobral had a deviation of 1.9 arcseconds which was almost twice the estimated number in the gravitational theory devised by English physicist Isaac Newton (1643-1727) Newton’s universal theory of gravitation became a specific example of Einstein’s general relativity,” explains Veiga “We can view the photographic plates produced in Sobral and Principe as a decisive moment in the history of 20th century science when ideas proposed by the theory of relativity had not yet been embraced,” says physicist and historian of science José Luiz Goldfarb of the Center Simão Mathias at the Pontifical Catholic University of São Paulo (PUC-SP) “Challenging the ideas derived from Newton related to classical mechanics met with strong opposition given that proposals from Einstein and other scientists completely changed our understanding of the world.” Goldfarb believes that conserving the photographic plates keeps alive the memory of the transformations that occurred in science early in the 20th century and still affect how we see the world today © Revista Pesquisa FAPESP - All rights reserved. Get the most important Jiu-Jitsu stories delivered straight to your inbox. ©2006 - Present FloSports, Inc. All rights reserved. Reading"João Sobral has a soft spot..." More fromWork Contact Advertising Opportunities Newsletters Insights + Opinion Creatives + Projects Advice + Resources Culture + Lifestyle Nicer Tuesdays The View From... POV Forward Thinking Review of the Year Jenny Brewer Olivia Hingley Ellis Tree Elizabeth Goodspeed Liz Gorny Extra Search “although I don’t really mind when other people do it I think the meaning of the word is very broad nowadays and different people use it to mean different things which is fine I’d say I’m a cartoonist and visual artist because I mainly make comics and drawings for personal work.” Having studied Communication Design in Porto the Glasgow-based practitioner originally hated drawing classes where the expected output was old-fashioned realism These classes were “an absolute nightmare” to João as the drawing he experienced were not creative or stimulating more “something with very specific rules that [he] was constantly doing wrong” with the guidance of an enthusiastic illustration tutor Rui Vitorino Santos João was introduced to “totally different drawing practices” that opened his mind to “new and fascinating worlds” beyond the realm of realism The cartoonist started doodling in sketchbooks that were meant for ‘real’ drawings but João “didn’t dare to call those doodles ‘drawings’” he embraced his own style and took pleasure in the unique way the drawings were created João learning to draw in his own way and developed a practice that evolved from an idea of drawing that to some people is the “wrong” way “I’m interested in the accidental nature of drawing — the things that happen when the hand is not trained," says João Like the subtle expression seen through a wobbly line rather than something that is ruler-straight João is more interested in a practice that evolves as a result of limitation The medium of comics consequently suits the cartoonist as it contrasts the “clumsy and awkward” way of drawing with a rigid layout João depicts his characters as “fragile beings” “I think I have a soft spot for people who are seen as losers or weirdos because they’ve been mistreated by the system.” His characters are “people who are kind and just want to love and be love but have a hard time navigating the world they’re stuck in.” Such characters continually crop up in João’s work firstly through the natural setting of comics which have now become “an obsession” João can further explore the deeper narrative behind the characters Drawing and writing come together to enhance the overall tone of the story and what the subjects are going through João can delve into his writing “without worrying too much about whether it is fiction or a poem this provides the viewer with emotive and often humorous storylines that are concisely delivered as well as visually stimulating Further Infowww.joaosobral.pt Jynann Ong Jynann joined It’s Nice That as an editorial assistant in August 2018 after graduating from The Glasgow School of Art’s Communication Design degree In March 2019 she became a staff writer and in June 2021 Fancy a bit of It's Nice That in your inbox Sign up to our newsletters and we'll keep you in the loop with everything good going on in the creative world Instagram TikTok LinkedIn Facebook Twitter Pinterest About Careers at It’s Nice That Privacy Policy Insights Residence Creative Lives in Progress If You Could Jobs © It’s Nice That 2024 · Nice Face Logo © It’s Nice That www.joaosobral.pt “I don’t use the word ‘illustration to refer to what I do” physicality-led practice reminds its audience of the person behind the piece In the newest instalment of his illustrated series Brian Blomerth explores the life of John C Lilly – the scientist that used ketamine to speak to dolphins Aysha Tengiz received a questionable contract asking her to give up rights to her own intellectual property the illustrator explains why that’s such dodgy practice and why creatives need to be more clued up about copyright Cofounded in 2022 by food industry creatives Cake Zine is back with its sixth issue: Daily Bread About Contact Advertising Opportunities Newsletters Insights + Opinion Creatives + Projects Advice + Resources Culture + Lifestyle Nicer Tuesdays The View From... POV Forward Thinking Review of the Year Jenny Brewer Olivia Hingley Ellis Tree Elizabeth Goodspeed Liz Gorny Instagram TikTok LinkedIn Facebook Twitter Pinterest Careers at It’s Nice That Privacy Policy Insights Residence Creative Lives in Progress If You Could Jobs Portuguese singer Salvador Sobral performs during the rehearsal ahead of the Eurovision Song Contest 2017 Grand Final at the International Exhibition Centre in Kiev Salvador Sobral won the 62nd Eurovision Song Contest 2017 with his song "Amar pelos dois" here on Saturday May 14 (Xinhua) -- Portuguese singer Salvador Sobral won the 62nd edition of the annual Eurovision Song Contest here on Saturday night with an emotional and romantic song Amar Pelos Dois (Love For Both) written by his sister During the final held at the International Exhibition Center in Kiev winning the highest possible score from the judges and the second highest score from the public vote Bulgaria's Kristian Kostov took the second place with 615 points followed by Moldova's participant with 374 points Portugal had not won the Eurovision Song Contest A total of 26 singers participated in this year's Grand Final of the Eurovision The race was viewed by more than 204 million TV audience in European countries and other countries across the globe "The Eurovision is the most famous song contest in the world. Each time millions of people from all over Europe, and recently from Australia as well, freeze in front of their TV screens rooting for their countries," said Ukrainian President Petro Poroshenko ahead of the contest Ukraine was granted the right to host Eurovision 2017 after its singer Susana Jamaladinova Chinese submersible explores turbidity current in South China Sea Straw art gala held in E China's Shandong Xinjiang Int'l Grand Bazaar held in Urumqi, NW China 8th China Peking Opera art festival to be held in Nanjing Firefighters on standby after heavy snowfall hits forest fire site in N China Aerial view of intertidal zone in E China's Jiangsu Hefei-Hamburg, Hefei-Almaty freight trains run regularly Jiaolong discovers collection of polymetallic nodules in South China Sea At the Eurovision Song Contest 2017 he sang “Amar pelos dois”, winning over Europe with his tale of “love for two”. And all the while Salvador Sobral knew exactly what he was talking about, as he was involved in a long-term relationship with girlfriend  — the French actress Jenna Thiam. Well today we were pleased to confirm that his girlfriend is now his wife, as Salvador and Jenna tied the knot on December 29th. That was just one day after he turned 29. Talk about a gift that will keep on giving! A post shared by wiwibloggs (@wiwibloggs) on Jan 2 As Portuguese publication Impala reported a former factory that is now an alternative cultural centre It’s known for countless musical events and frequently hosts jazz performances which suggests the Eurovision 2017 winner felt right at home the wedding was celebrated in both Portuguese and French to honour both sides of their union she modelled as a teenager before giving it up to pursue acting full-time she turned down a role in Pirates of the Caribbean: Dead Men Tell No Tales so that she could finish her acting degree at the National Conservatory of Dramatic Arts of Paris Jenna was seen supporting Salvador on-the-ground in Kyiv She was with him prior to his heart troubles and stayed with him through the difficult and uncertain period of his transplant Having already survived that mammoth ordeal — and his celebrity post-Eurovision — it seems their romance really will stand the test of time William Lee Adams is the founder and editor-in-chief of wiwibloggs. His memoir “Wild Dances: My Queer and Curious Journey to Eurovision” is available now. You can follow him on Instagram @williamleeadams and Twitter @willyleeadams Poor of her to have to stand this egotistical man who are centrred on cheap techno beat and call that music which will be released in his upcoming album i want an Indian wedding just like Nick and Priyanka How can they have an indian wedding if none of them are Indian I don’t think Salvador would enjoy the attention and glamour if it did he had fast food music at his weeding or not Some videos of the wedding show that he sang on piano Amar pelos dois; also played with Luisa “Só um beijo” a beautiful new song of Luisa and Salvador There was also some jazz music played by his friends….what a beautiful wedding it must have been I remember her from “Les Revenants” They’ve been through a lot in the last few years I hope they can now live a very calm and fulfilling marriage Ah I recognise her from a really good French TV series Can’t believe I didn’t realise it was her in Kyiv but the truth is that Salvador is insatiable in the bedroom I’m super happy for them and wish them the best <3 You mean handle being in love with a beatiful human being it seems that his heart doesn’t have to amar pelos dois anymore… Huge congratulations to Salvador and his wife in the first sentence it says he won Eurovision in 2019 Ukraine (AP) - A gentle romantic ballad challenged the Eurovision Song Contest's decades-long reputation for cheesy Portugal's Salvador Sobral sang his Amar Pelos Dois (Love For Both) in a high clear tenor accompanied by quiet strings and a piano in Saturday night's.. This document may not be reprinted without the express written permission of Chattanooga Times Free Press Material from the Associated Press is Copyright © 2025 audio and/or video material shall not be published rewritten for broadcast or publication or redistributed directly or indirectly in any medium Neither these AP materials nor any portion thereof may be stored in a computer except for personal and noncommercial use The AP will not be held liable for any delays errors or omissions therefrom or in the transmission or delivery of all or any part thereof or for any damages arising from any of the foregoing The ad-free version is ready for purchase on iOS mobile app today we couldn't find that page";var n=e.querySelector("h2");return n&&n.remove(),{staticContent:e,title:t}},d=function(e){var t=document.createElement("button");return t.innerText=e,t.classList.add("error-page-button"),t},f=function(e){var t=document.createElement("div");t.id="recirculation-404",t.classList.add("brand-hint-bg");var n="\n \n \n \n \n \n '.concat(e,' Tick here if you would like us to send you the author’s response