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Suscribe x MercoPress, en Español Montevideo, May 6th 2025 - 09:48 UTC Supermarket sales in Argentina have dropped by 8% while wholesale sales have plummeted by 22% under President Javier Milei a report from the University of Buenos Aires showed Tuesday The decline is attributed to adjustment policies causing high inflation and tariff hikes redirecting spending from consumer goods to basic services thus reversing a brief recovery between January and November 2023 (before Milei took office) Industrial production also fell by about 5% in 2024 with textiles and basic metals hit hardest though food and beverage production rose slightly Despite some economic growth in early 2025 with a 5.4% year-on-year drop in March and an 8.6% fall in Q1 2025 Sectors like alcoholic beverages and hygiene products saw significant declines while durable goods like appliances and cars surged due to credit expansion with many expecting weak domestic demand and reduced capacity utilization in the near term “The recovery of sales observed from January to November 2023 came to an end where the accumulated increase in wholesale sales was 4.60% and that of supermarket sales was close to 3%” the UBA's RA Center specified in a report published on X The document also mentioned “a deepening of the fall in both wholesale and retail sales is foreseen,” which “is due to the loss of purchasing power of wages due to the strong inflationary jump resulting from the adjustment policies at the beginning of the government and the increase in tariffs that produced a reallocation of income from consumer goods to basic services.” “Industry was one of the economic sectors most affected by the adjustment,” warned the study based on data from the National Institute of Statistics and Census (INDEC) A typical family of four needed almost AR$ 1,150,000 (around US$ 1,000) in March not to be poor in the Autonomous City of Buenos Aires production increased by 6.9% in cumulative terms being one of the least affected industries along with oil refining which increased its production by just under 5% in cumulative terms by 2024 “Despite the economic growth reported in recent months the expectations of industrial producers are not good for economic activity in general and industrial activity in particular in the short term,” the report also pointed out The UBA study also referred to “an incipient recovery of economic activity on the supply side is observed in some productive sectors mainly commerce and industry,” which nevertheless does not offset “even a small part of the destruction of activity generated by the government's adjustments,” with no positive signs “on the demand side,” probably “due to the deterioration of salaries due to the exchange rate delay and the liquefaction of these in some sectors of the economy such as the public sector and pensions.” Connecting decision makers to a dynamic network of information Bloomberg quickly and accurately delivers business and financial information The offices of United Bank for Africa Plc (UBA) left, in the Central Business District (CBD) of Lagos.  as it aims to meet the central bank’s new threshold and expand into more countries This, and the 240 billion naira raised through a rights issue should enable UBA meet the 500 billion naira minimum capital requirement set by the Central Bank of Nigeria chief executive officer said in an emailed statement United Bank for Africa (UBA) Ghana Ltd has demonstrated robust financial and operational performance for the 2024 financial year The bank made this announcement at its 2024 Annual General Meeting (AGM) held  in Accra where shareholders applauded the solid strides made despite a challenging economic landscape UBA Ghana recorded a Profit Before Tax (PBT) of GHS 253.58 million reflecting effective deposit mobilization efforts and deepened customer engagement The bank also posted a 25% growth in total assets signalling the strength and sustainability of its balance sheet the bank achieved a dramatic improvement in asset quality reducing its Non-Performing Loans (NPL) ratio from 24.7% to 12.5% following aggressive loan recovery and strengthened risk management practices “This performance reflects the strength of our governance and the trust our customers place in us,” said Mr “We remain steadfast in our goal to build a future-ready bank that contributes meaningfully to Ghana’s economic development.” UBA Ghana’s 2024 success was underpinned by a strategic focus on digital transformation The bank recorded strong growth in fees and commissions and plans to further leverage this revenue stream in 2025 as part of its long-term growth strategy “Our transformation journey is far from over,” said Mr Managing Director and Chief Executive Officer of UBA Ghana and invest in technologies that help us serve our customers better while responding swiftly to regulatory changes and market dynamics.” Amid the broader industry shifts—rising regulatory expectations and technological disruption—UBA Ghana is reinforcing its market position through proactive customer engagement To mitigate risks like exchange rate volatility and sluggish private sector growth the bank has adopted a multifaceted approach Key actions include building FX liquidity buffers partnering with exporters and remittance channels and aligning its lending strategy with market trends The bank is also engaging with Development Finance Institutions (DFIs) and exploring Public-Private Partnerships (PPPs) to co-finance transformational projects UBA Ghana announced plans to establish a presence in all sixteen regions of Ghana shareholders also applauded the bank’s intensified Environmental and introduced braille-enabled banking documents to support visually impaired customers “We’re building more than a bank—we’re building a platform for empowerment UBA Ghana’s strong 2024 performance and forward-looking strategy reaffirm its role as a key enabler of inclusive financial growth and a partner in Ghana’s 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The German Environment Agency (UBA) has launched a free chemical management tool, which aims to help companies of any size conduct quick sustainability assessments of chemical substances and formulations. The new ChemSelect tool presents chemical assessments via an easy-to understand traffic light system (green, yellow, red), which analyses the potential for ie, human toxicity, global warming potential, and supply chain responsibility. Explore all our independent journalism from as little as 30p per day. Less than an espresso - but more stimulating. Create an accountNewsletterRead our top news stories delivered straight to your inbox. Search View more... Help to support the purpose-led work of our team of journalists and partners – and expose your product or service to our global readership Request a media pack which details the benefits of advertising on ETN including our rates and details of our distribution please fill out the form below: YOUR DETAILS – See our privacy policy here for details of how we take your privacy very seriously Advertising Terms and Conditions Subscribe to our magazine today and receive exclusive online content '+scriptOptions._localizedStrings.webview_notification_text+' "+scriptOptions._localizedStrings.redirect_overlay_title+" "+scriptOptions._localizedStrings.redirect_overlay_text+" Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Global Finance Magazine Global news and insight for corporate financial professionals Global Finance has announced its selection of global winners for the 26th annual World’s Best Banks including its honouree for the World’s Best Frontier Market Bank the 2024 World’s Best Frontier Market Bank is UBA “United Bank for Africa continued to deliver on its dedication to serving domestic and international businesses while providing financial inclusivity during 2023’s slowing economic growth The pan-African bank’s robust risk management and strategic internal investments delivered stellar financial returns making it stand out from the competition in the frontier markets.” said Joseph Giarraputo founder and editorial director of Global Finance corporate and banking leaders have turned to Global Finance’s Best bank awards to identify financial partners who not only excel in their offerings but also adapt and innovate in an ever-evolving market.” Winners were selected based on performance over the past year and other criteria including reputation and management excellence Global Finance’s editorial board made the selections with input from corporate financial executives The editors also used entries submitted by banks for Global Finance’s 2024 awards programs to evaluate a series of objective and subjective factors Global Finance will hold its 26th annual World’s Best Bank Awards alongside the IMF/World Bank Annual Meetings in Washington Legit.ng Hausa ta bude tasha a manhajar Whatsapp. Kasance tare da mu don samun rahotanni da dumi-dumi! A'isha Ahmad edita ce a sashen Hausa na Legit Tana da ƙwarewa wajen rubutun labarai da rahotanni tsawon shekaru uku al'amuran da su ka shafi mata da yara da siyasa Jihar Kaduna - Gwamnan Kaduna, Uba Sani, ya bayyana cewa jihar ba ta samu wani rikici na kabilanci ko na addini a cikin shekaru biyu da suka wuce ba. Ya bayyana cewa rashin rikice-rikice a jihar na daga cikin sakamakon rawar da shugabannin gargajiya ke takawa wajen tabbatar da zaman lafiya. Kara karanta wannan Gwamna Uba Sani ya ce an samu raguwar rikicin addini da kabilanci a Kaduna Hoto: Senator Uba SaniAsali: FacebookThe Cable ta wallafa cewa Gwamnan ya bayyana hakan ne a lokacin rarraba motoci 23 ga shugabannin gargajiya a gidan Sir Kashim Ibrahim a ranar Lahadi LURA: Shin kana son bamu labari da tattaunawa da marubutanmu Daily Trust ta ruwaito cewa Gwamna Uba ya nuna cewa suna aiki tukuru suna musayar bayanai tare da jami'an tsaro Gwamnan Kaduna ya jaddada muhimmancin hadin kai tsakanin cibiyoyin gargajiya shugabannin al'umma da hukumomin tsaro don wanzuwar zaman lafiya Gwamna Uba Sani ya jinjinawa shugaban majalisar wakilai, Tajudeen Abbas a kan yadda ya waiwayi sarakunan gargajiya a jihar Kaduna. Kara karanta wannan ACF: Dattawan Arewa sun gindaya sharadin goyon bayan 'dan takara a zaben 2027 Ya ce an raba motoci ne ga shugabannin gargajiya domin ya kara masu kwarin gwiwa ya jaddada muhimmancin rawar da suke takawa wajen tattara bayanan sirri da kuma musayar su Tajudeen Abbas Hoto: Tajudeen AbbasAsali: FacebookA nasa bangaren Tajudeen Abbas ya ce an raba motocin ta hannun Hukumar Ci gaban Kanana da Matsakaitan Masana'antu (SMEDAN) Ya bayyana hakan a matsayin wani bangare ne na shirin rarraba motocin a mataki na hudu na domin karfafawa sarakunan yankin Hon Tajudeen ya ce motocin za su zama tamkar kayan aiki da za su taimaka wa shugabannin gargajiya wajen zuwa dukkanin yankunan masarautarsu don kara wanzar da zaman lafiya A baya, kun ji cewa wasu 'yan bindiga sun sace Harira Abdullahi matar Hakimin Aboro da ke ƙaramar hukumar Sanga a Jihar Kaduna tare da 'yarta Maryam Suleiman Galadima Rahotanni sun ce miyagun 'yan bindigan sun kutsa cikin gidan hakimin da misalin ƙarfe 7:36 na yamma suka yi awon gaba da matarsa da 'yarsa ba tare da sun fuskanci wata barazana ba mazauna garin sun yi ƙoƙarin bin 'yan bindigan cikin daji domin ceto su aka kashe wani daga cikin masu kokarin ceto su United Bank for Africa (UBA) Plc has once again demonstrated its strength in the banking sector reporting remarkable profitability growth for the full year ended December 31 submitted to the Nigerian Exchange Limited (NGX) on Monday highlighted significant improvements across all key financial indicators The bank’s gross earnings also experienced substantial growth rising by 53.6% from N2.08 trillion in 2023 to N3.19 trillion in 2024 closing at N30.4 trillion in December 2024 compared to N20.65 trillion recorded in 2023 This marks a significant milestone for the bank which has the widest geographical presence across Africa Shareholders to Benefit from Strong Performance As part of its commitment to delivering value to shareholders UBA has declared a final dividend of N3.00 per share for every ordinary share of 50 kobo bringing the total dividend payout for the year to N5.00 per share This decision aligns with the UBA Group Chairman Tony Elumelu’s promise at the last Annual General Meeting Management’s Perspective on Growth and Performance UBA’s Group Managing Director/Chief Executive Officer expressed excitement over the bank’s outstanding financial performance emphasizing the institution’s focus on driving earnings growth “Our continued investment in our highly diversified global network allows UBA to deliver high-quality Our businesses have been able to grow product and service income and expand our deposit base allowing the Group to increase earnings while maintaining strong spreads and margins,” said Alawuba The CEO further pointed out that UBA’s total deposits increased by 42.03% from N17.4 trillion in 2023 to N24.7 trillion in 2024 he attributed this performance to broad-based growth across all core business areas Alawuba also highlighted the bank’s expansion efforts “Our ex-Nigeria (Rest of Africa & International) operations have expanded significantly over the past five years This reflects our successful diversification strategy which continues to boost long-term shareholder value We are currently upgrading our business scope and authorization in France while exploring other viable markets.” Robust Financial Position and Asset Quality UBA’s Executive Director of Finance & Risk Management underscored the bank’s strong capital base and improved asset quality “UBA Group continues to demonstrate strong capital levels with shareholders’ funds increasing by 68.4% to N3.42 trillion and a capital adequacy ratio of 31.0% our net interest margin improved from 6.83% in 2023 to 9.02% supported by triple-digit growth in net interest income,” Nwaghodoh noted He further stated that UBA’s non-performing loan (NPL) ratio moderated to 5.58% reflecting the bank’s proactive risk management approach amid global economic uncertainties Strategic Focus on Innovation and Technology UBA continues to prioritize investments in technology all of which aim to enhance customer experience and drive efficiency our management remains focused on responsible growth delivering customer-centric value propositions and ensuring compliance with regulatory requirements in all jurisdictions,” added Nwaghodoh UBA’s Position as a Leading African Financial Institution With a workforce of 25,000 employees and serving over 45 million customers globally UBA maintains a strong presence in twenty African countries The bank remains committed to financial inclusion reinforcing its reputation as Africa’s Global Bank As UBA expands its footprint and strengthens its financial position shareholders and investors can anticipate sustained growth and value creation in the coming years Temitope is an astute writer and editor with keen interest in geo-politics With a keen eye for insightful storytelling and analysis inspire and is dedicated to advocating for positive change and national transformation Nigeria’s former Vice President Atiku Abubakar has criticised the arrest and ongoing detention of social… David Olujinmi $(document).ready(function(){(adsbygoogle = window.adsbygoogle || []).push({})}); BusinessDay UBA paid out N171 billion as total dividends to its shareholders representing a 79 per cent increase from the N95.8 billion paid for 2023 During its 63rd Annual General Meeting held on April 25 UBA shareholders approved the proposed N3 per share final dividend it represents a 23 per cent total dividend payout ratio for FY 2024 the group had a total dividend payout ratio of 16 per cent UBA posted a pre-tax profit of N803.7 billion for FY 2024 marking a 6 per cent growth from the N757.7 billion recorded for FY 2023 it was a 26 per cent growth to N766.6 billion from N607.7 billion as of FY 2023 As part of the rewards for its stellar performance in 2024 UBA has improved its return to shareholders even as it looks to carry out a second rights issue in 2025 Read Also: NDIC pays N46.6bn liquidation dividends to depositors of Heritage Bank After raising N239.4 billion through a rights issue in 2024 the bank plans another rights issue in Q3 2025 to complete the N500 billion minimum capital requirement “The final capital raise is expected to be completed in Q3 2025 noted that the bank will continue to increase its return to shareholders “What we can assure our shareholders today is that UBA will continue to pay more dividends.” (Business in Cameroon) - Cameroon has officially taken the lead among all subsidiaries of the United Bank for Africa (UBA) group in terms of net profit UBA Cameroon posted a net profit of 64.4 billion naira according to the group’s audited annual report This puts UBA Cameroon ahead of the Ivorian branch which came in second with a net profit of 55.6 billion naira It also marks a 51% increase compared to 2023 when the bank reported CFA16.2 billion in net profit While part of the rise reflects the weaker naira—down 6.7% against the Central African CFA franc—the numbers also point to strong growth in the bank’s core activities Net banking income (the equivalent of revenue) tripled from CFA37 billion in 2023 to nearly CFA96.7 billion in 2024 This boost came largely from increased investment in debt securities which grew by 36.3% to reach CFA403 billion These now make up over half (53.08%) of UBA Cameroon’s total assets—a level the IMF considers risky Loans to private-sector clients jumped 47.3% in 2024 Another area to watch is the bank’s shrinking cash flow from operations UBA Cameroon generated about CFA118 billion in 2024 Cameroon is now a key pillar of UBA’s pan-African operations—outperforming even the group’s home market in Nigeria when it comes to profit contribution Kribi Bitumen Plant Set to Start Construction in 2025 with Government Backing CEMAC Bond Market Hits CFA 8.45 Trillion in March 2025, Interest Rates Drop Cameroon’s Timber Output Projected to Rise in 2025 Despite Higher Export Taxes Central Africa Stock Exchange Sees 98% Drop in Trading Value in Q1 2025 Every week the economy and investment news from Cameroon Mboa Paris Trains 30 Young Cameroonians to Boost Tech and Entrepreneurship Cameroon Audit Targets Former Officials for Mismanagement in Agricultural Project Camwater Seeks Global Bids to Launch Bottled Water Lines in Five Cities Bafoussam Workshop Highlights Benefits of Cameroon-EU Trade Agreement Cameroon Could Reach 350,100 Tons of Cotton in 2025 (Beac) Paul Biya Appoints Johnny Razack as Chair of Cameroon’s National Investment Company Cameroon Refuses Work Visa Renewal for Casino and Super U Boss Over Toxic Workplace Claims Cameroon Joins Global Charter to Fight Illegal Fishing Governor Uba Sani of Kaduna State has embarked on a transformative journey to address youth unemployment and insecurity through strategic investments in skills acquisition and vocational training Recognizing the critical need to empower the youth Governor Sani’s administration has initiated several key projects aimed at equipping young individuals with relevant skills for the modern workforce One of the cornerstone initiatives of Governor Uba Sani’s administration is the development of Vocational and Technology Skills Acquisition Cities in Rigachikun These centers are designed to provide comprehensive training in various technical and vocational skills and information and communication technology (ICT) The centers aim to train and certify 400 youths quarterly thereby significantly contributing to the reduction of youth unemployment in the state To ensure the quality and recognition of the training programmes the Kaduna State Government has partnered with the National Board for Technical Education (NBTE) This collaboration facilitates the provision of the National Skills Qualification Framework (NSQF) certification a globally recognized credential that enhances the employability of graduates both within Nigeria and internationally the centers offer certifications from renowned organizations such as Microsoft further bolstering the credentials of the trainees In a bid to integrate traditional craftsmanship with modern vocational training Governor Sani’s administration has undertaken the remodeling of the Panteka Market in Tudun Wada This initiative aims to transform the market into a major center for skills acquisition and job creation The remodeled market will offer training in carpentry providing artisans with opportunities to enhance their skills and improve their livelihoods To oversee and coordinate the state’s skills development efforts Governor Sani inaugurated the Kaduna State Skills Development Council in August 2024 the council serves as the highest decision-making body for skills development in the state Its primary responsibilities include developing a skills development framework and supervising the execution of operational plans aimed at addressing youth unemployment The council’s formation underscores the administration’s commitment to a structured and sustainable approach to skills development The initiatives spearheaded by Governor Sani have had a profound impact on youth unemployment and the much acclaimed non kinetic approach in stemming insecurity in Kaduna State By providing young individuals with marketable skills the programmes have enhanced their employability and entrepreneurial potential thereby reducing the economic factors that often contribute to insecurity The training centers not only equip youths with technical skills but also foster a culture of self-reliance and innovation empowering them to contribute positively to society the emphasis on digital skills and modern technologies positions Kaduna State as a potential hub for technological innovation and industrial growth The integration of ICT and artificial intelligence into the training programmes ensures that the youth are prepared for the demands of the global economy making them competitive in various sectors Governor Uba Sani’s strategic focus on skills acquisition and vocational training has set a commendable precedent in addressing youth unemployment and insecurity in Kaduna State Through the establishment of specialized training centers collaboration with national educational bodies and the transformation of traditional markets into modern skills hubs his administration has laid a solid foundation for sustainable youth empowerment they hold the promise of a more prosperous and secure future for the youth of Kaduna State in his bid to speedily lift as many underserved citizens of the state from multi-dimensional poverty Governor Uba Sani has prioritized the inclusion of underserved and unbanked citizens in the financial services sector Governor Sani initiated several measures to integrate persons that fall within this demography in Kaduna State into the formal financial system Governor Sani signed an Executive Order aimed at bringing approximately 2.5 million underserved and vulnerable citizens into the financial services sector The order mandated the development of a state financial inclusion strategy the establishment of a state register for the poor and vulnerable and collaboration with banks and fintech companies to open bank accounts for unbanked individuals The initiative also included aggressive sensitization programs and financial literacy workshops to equip citizens with the necessary skills to make informed financial decisions a leading Nigerian payment and switching firm This collaboration introduced innovative banking products such as Credo and PocketMoni designed to be accessible to a wide range of people nearly 3 million residents in Kaduna State have benefited from these easy-to-use banking solutions enabling them to access government interventions and financial services seamlessly At the Kaduna Economic and Financial Inclusion Summit (KEFIS 2025) with the  theme: Expanding Financial Access for Sustainable Development Governor Uba Sani set out to consolidate Kaduna State’s achievements in financial inclusion and further expand financial access to the unbanked with particular focus on enhancing economic inclusion for vulnerable populations in the State “Financial inclusion stands as a cornerstone of sustainable economic empowerment and societal progress It goes far beyond the mere act of opening bank accounts True financial inclusion is about granting individuals and communities the means to participate meaningfully in the economy and elevate their quality of life through access to essential financial services,” Governor Uba Sani averred at the Summit Governor Uba Sani told participants and guests that included Vice President Kashim Shettima (who was represented by the Deputy Chief of Staff to the President that he was happy to report that Kaduna State’s sustained economic and financial inclusion drive had significantly reduced the poverty rate and income inequality in the state “Access to financial services and credit has lifted many people out of poverty We have also been consciously and deliberately supporting Micro significantly contributing to job creation They drive local economies and provide livelihoods for millions of our citizens This is why my administration has committed itself to creating an enabling environment for businesses to flourish fostering a vibrant entrepreneurial ecosystem where MSMEs can grow and contribute to the economy of Kaduna State More MSMEs have been created due to our interventions,” the Governor further remarked at the Summit understanding the importance of MSMEs in economic development Governor Uba Sani allocated a N4.2 billion relief fund to assist over 4,000 SMEs and vulnerable households facing economic hardships This intervention is aimed to alleviate the adverse effects of the fuel subsidy removal and the rising cost of living the Kaduna State Enterprise Development Agency (KADEDA) supported 8,649 nano and micro businesses with grants ranging from N50,000 to N300,000 enabling them to expand their operations and contribute to the state’s economic growth To further support the financial needs of civil servants Governor Sani launched a N500 million Revolving Loan Scheme with a single-digit interest rate of 5% This initiative aimed to provide civil servants with easy access to funds thereby alleviating financial stress and improving their overall welfare the state government has disbursed approximately N4.7 billion for the settlement of death and gratuity benefits demonstrating its commitment to the welfare of workers Governor Sani’s financial inclusion initiatives have not only integrated millions of underserved citizens into the financial system but have also contributed to the state’s economic development The introduction of digital banking solutions has facilitated access to government interventions while the support for MSMEs has stimulated local businesses and job creation the financial literacy programmes have empowered citizens to make informed financial decisions fostering a culture of savings and investment Governor Uba Sani’s proactive approach to financial inclusion has significantly impacted the lives of underserved and unbanked citizens in Kaduna State his administration has laid a solid foundation for inclusive economic growth and development they hold the promise of a more prosperous and financially inclusive future for all residents of Kaduna State Adeola Ajakaiye Products are chosen independently by our editors Purchases made through our links may earn us a commission I made the switch not because I’ve been hitting the local skate park (I’m more of a roller-skating guy) narrow profiles of skate shoes make them the more versatile option for styling an outfit Not only are the brand’s skate shoes stylish and trendy being spotted on celebrities like Pete Davidson but they’re also made from sustainable materials But I know not all that glitters is gold—I put sole to pavement to see if Cariuma’s new function ga4_link78() { window.dataLayer.push(JSON.parse('{"event":"default_event"}')) }UBA Pros could walk the walk with materials that are described as ethically-sourced and sustainable The brand also states that it plants two trees for every pair of shoes bought Cariuma is already one of the trendiest footwear brands out there with its shoes being spotted on the feet of celebrities like Robert Downey Jr. The UBA Pro is the latest sneaker line from Cariuma consisting of designs that bridge the gap between short and flat skater shoes like Vans and chunkier sneakers a rubber outer layer of the shoe that “cups” the upper portion of the shoe making the shoe more supportive and durable The Uba Pro is available in both “leather” which features an upper made of premium, function ga4_link81() { window.dataLayer.push(JSON.parse('{"event":"default_event"}')) }ethically-sourced leather and suede (as well as a “mixed” option which features a pure suede upper) Leather has 7 different colorways and mixed has 6 Both variations are available in men's and women’s sizes 5 through 13 function ga4_link82() { window.dataLayer.push(JSON.parse('{"event":"click_affiliate","affiliate_merchant":null,"affiliate_network":null,"affiliate_button_type":"button"}')) }Shop Cariuma The most striking thing about the UBA Pros is the fact that they effortlessly and masterfully blend the strengths of skate shoes and gym shoes The UBA Pros’ low profile and flat soles give them the low-key and casual look of traditional skater shoes like Vans give the shoes the structure and bulk to stand toe-to-toe with athletic shoes The result is a shoe that is heard without being loud; something that’s lowkey without fading into the background of the rest of your outfit The shoe is well-suited to a variety of occasions whether you need to mindlessly throw on some shoes for a quick grocery run or want to look effortlessly cool while grinding rails at the skate park After my experience with function ga4_link83() { window.dataLayer.push(JSON.parse('{"event":"click_inarticle"}')) }Adidas’ Samba Shoes I was ready for a painful and awkward break-in period The Uba Pros are comfortable right out of the box I was impressed by how comfortable they were to walk in as skate shoes aren’t typically known for being the best walking shoes were an absolute dream on my feet even on the rough and uneven trails of my local park There were times when I didn’t want to take them off in my house — they’re that comfortable which is what makes the shoe so supportive making each step feel like you’re walking on a cloud since it’s one of the roomier fits I’ve tried in terms of width I struggled to find something I legitimately disliked about the Uba Pros—what I landed on was incredibly minor The insole that comes with the shoe is on the thicker side While I personally wouldn’t take out the insole due to the cushion it provides it’s thick to the point where the top of the shoe can feel a bit tight after wearing it for a while but it’s something to note if you have more sensitive feet I’m absolutely in love with Cariuma’s latest sneaker They do a terrific job of combining the best of skate and athletic shoes If you’re looking for a versatile shoe that can do well on just about any outfit and keep you comfortable in dozens of situations The popular brand has the perfect combination of skate and athletic shoe Prices were accurate at the time this article was published but may change over time United Bank for Africa (UBA) Plc has reinforced its commitment to peace and stability across Africa with a significant $500,000 donation to the African Union (AU) Peace Fund The contribution aligns with the AU’s mission to promote security and sustainable development in line with the Africa Agenda 2063 vision of a unified and prosperous continent The AU Peace Fund plays a key role in financing mediation efforts and preventive diplomacy to address conflicts across Africa. By supporting this initiative, the bank demonstrates its dedication to fostering economic growth through regional stability The bank’s commitment reflects its long-standing belief that peace is fundamental to sustainable development Chairman of the AU Peace Fund Executive Management Committee emphasised the importance of financial support in achieving stability stating that peace is synonymous with resources He praised UBA for its dedication to Africa’s development and acknowledged the donation as a testament to the bank’s commitment to securing a better future for the continent UBA Group Chairman, Tony Elumelu, announced the donation in Addis Ababa highlighting the crucial role of corporate institutions in shaping Africa’s future He stressed that investment in peace and security creates an environment where businesses sustainable development is closely linked to stability and UBA remains committed to uplifting lives across Africa by fostering both economic growth and security With operations in over 20 African countries UBA firmly believes in the continent’s potential Elumelu urged businesses and organisations to contribute to the collective effort of achieving peace as development is only possible in a stable environment He also commended the African Union for its dedication to ensuring peace and security expressing UBA’s pride in partnering with the organisation and seeking deeper collaboration in the future UBA Group has consistently demonstrated its commitment to Africa’s progress previously provided $14 million in support of a Pan-African response to the COVID-19 pandemic and financial assistance to Nigeria and 19 other African nations The AU Peace Fund, a crucial financial mechanism under the African Peace and Security Architecture (APSA), supports peace-building initiatives, conflict prevention, and institutional capacity building across the continent. The bank is a major employer in Africa’s financial sector with 25,000 staff members serving over 45 million customers worldwide Onyinye Nwachukwu Anthony Ailemen The Catholic Bishop of Sokoto Diocese, Bishop Matthew Hassan Kukah, has commended Governor Uba Sani for his efforts in stabilising Kaduna State given its strategic importance in the country Bishop Kukah who is also the Pro-Chancellor of Federal University of Applied Sciences praised the Governor for going beyond the call of duty in making the university a reality The Bishop gave these accolades when he and members of the university’s management paid a courtesy call on Governor Sani at Sir Kashim Ibrahim House The Pro-Chancellor disclosed that the Vice Chancellor departments and agencies of Government to facilitate the commencement of academic session Bishop Kukah who said that the Federal University of Applied Science has built on the pioneering efforts of the former NOK University promised that it will be one of the best in the country the university will commence academic session in September but it has a few challenges that that will require the intervention of Kaduna State The clergyman said that the university will need more infrastructure in the coming years and for this reason adding that the school will also require access road researched reporting relies on the support of readers like you Help us maintain free and accessible news for all with a small donation Every contribution guarantees that we can keep delivering important stories —no paywalls The Pro Chancellor also said that the Federal University of Applied Sciences will require utility vehicles and adequate security Governor Sani said that he has been working closely with Bishop Kukah on not just the University but on a number of issues adding that the clergyman has been a pillar of support his doors are always open as he reiterated his commitment to deepen consultation amongst the diverse people of Kaduna State irrespective of their ethno-religious or party affiliations He said that his developmental strides in Kaduna State was made possible because of the prevailing peace adding that there has never been any ethnic or religious crisis since he assumed office about two years ago The Governor also argued that peace was achieved because of his administration’s policy of taking development to every part of the state irrespective of whether or not the area voted for him Mr Sani disclosed that the Minister of Education promised that funds will be made available to the Federal University of Applied Sciences Kachia through TETFUND He also promised to give the university more land adding that the Managing Director of Kaduna State Roads Agency(KADRA) will assess the access road to the school for necessary action Governor Sani noted that although there are a lot military formations in Kachia he will collaborate with the Chief of Defence Staff to strengthen security Support PREMIUM TIMES' journalism of integrity and credibility we firmly believe in the importance of high-quality journalism Recognizing that not everyone can afford costly news subscriptions we are dedicated to delivering meticulously researched fact-checked news that remains freely accessible to all Whether you turn to Premium Times for daily updates in-depth investigations into pressing national issues It’s essential to acknowledge that news production incurs expenses and we take pride in never placing our stories behind a prohibitive paywall Would you consider supporting us with a modest contribution on a monthly basis to help maintain our commitment to free TEXT AD: Call Willie - +2348098788999 All content is Copyrighted © 2025 The Premium Times, Nigeria Please enter your username or email address to reset your password All content is Copyrighted © 2025 The Premium Times, Nigeria The upgraded platforms form part of the bank’s ongoing campaign with the theme: Innovation for Progress: Empowering SMEs, Connecting Communities, Simplifying Banking. The newly improved PoS, which provides customers efficiency and ease in transacting their businesses, boasts of exciting features designed to boost efficiency, transparency, and trust for merchants; including instant settlement, real-time monitoring, pay-by-link functionality, and a 100% transaction success rate. With the new service, customers can enjoy flexibility, as the terminals have been equipped to serve businesses of all sizes, providing the speed, reliability and fast-paced services demanded by today’s merchants. Speaking on the modified features of both platforms, UBA’s Group Head, Retail and Digital Banking, Shamsideen Fashola, said, that as a forward-thinking financial institution, UBA is always on the look-out for modern ways to improve their services and offerings, to give customers top-notch experiences while conducting their daily businesses. He said, “At UBA, we are constantly innovating to provide seamless and secure payment solutions for businesses of all sizes. The new UBA PoS and MONI App is designed to empower merchants and agency banking with instant settlements, real-time transaction tracking, and unmatched reliability – ensuring they can focus on growing their businesses with a trusted partner.” Fashola explained that the bank’s continued investment in digital infrastructure aligns with its broader commitment to supporting African businesses through technology-driven banking solutions that deliver value, scalability, and trust. UBA’s Group Head, Marketing and Corporate Communication, Alero Ladipo, emphasised the bank’s unwavering commitment to delivering innovative solutions that meet the evolving needs of its customers. “We understand that speed, transparency, and reliability are critical for business growth, and that’s exactly what the new UBA POS and Moni App delivers. At UBA, we are not just providing a payment device, we are offering a promise of efficiency, trust, and support to the thousands of businesses that rely on us daily. This solution is a testament to our dedication to helping our customers thrive in today’s digital economy,” she noted. Ladipo called on Merchants, Agent Banking partners and business owners to experience the myriad of offerings available by visiting any UBA branch nationwide or through the bank’s website at www.ubagroup.com. United Bank for Africa is one of the largest employers in the financial sector on the African continent, with 25,000 employees group wide and serving over 45 million customers globally. Operating in twenty African countries and the United Kingdom, the United States of America, France and the United Arab Emirates, UBA provides retail, commercial and institutional banking services, leading financial inclusion and implementing cutting edge technology. Save my name, email, and website in this browser for the next time I comment. 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Chinwe Michael United Bank for Africa (UBA) aims to extend its operations to over 100 countries and serve one billion customers within the next 75 years Speaking at UBA’s 75th anniversary gala dinner in Abuja Mr Alawuba outlined a long-term strategy focused on growth across Africa and the world we envision a UBA with a presence in every African country and will expand its footprints to over 100 countries across the world,” Mr Alawuba said “UBA will serve more than one billion customers Established in 1949 as the British and French Bank on Kakawa Street in Lagos the CEO said UBA has grown to operate in 20 African countries and four global financial centres – New York the bank serves over 45 million customers through 1,000 business offices Mr Alawuba also highlighted UBA’s strong financial performance in 2024 The bank’s gross earnings surged 53.6 per cent to N3.19 trillion ($2.14 billion) while total assets rose by 46.8 per cent to N30.32 trillion ($19.58 billion) “These milestones stand on the pillars of stability and excellence – pillars that have anchored UBA’s growth over the last seven and a half decades,” he said He praised Elumelu as “a foremost entrepreneur attended the event as the special guest of honour Mr Alawuba acknowledged Shettima’s continued support for UBA’s vision of Africa’s economic integration this moment is particularly meaningful for us as you are not only a respected national leader but also a valued part of the UBA family,” Mr Alawuba said he reiterated UBA’s commitment to advancing Africa’s development through innovation and private-sector growth we are building more than a bank; we are building a future for the next generation of Africans – one defined by opportunity commended UBA’s resilience and transformation “Seventy-five years is not something you pick up at a supermarket It is earned — through risks and calculations and through the brainpower and courage of those who believe in its promise of a new world That is what leadership means,” Mr Shettima said He highlighted UBA’s ability to stay relevant across generations attributing it to the bank’s focus on innovation and adaptability “UBA has remained a pacesetter because it is led by people who do not just manage capital but manage curiosity,” he stated The Vice President also praised Tony Elumelu’s leadership describing him as “a dream-maker” who bridged generational gaps and redefined African leadership He has made true the imagination of those who wish for an empire from the comfort of their homes,” he said The bank had earlier on Friday announced plans for early recapitalisation to meet the Central Bank of Nigeria’s new capital requirement of N500 billion for banks with international licences UBA aims to achieve this by the third quarter of 2025 UBA reported a profit after tax of N767 billion The bank launched its recapitalisation process in November 2024 with a rights issue offering 6.84 billion ordinary shares at N35 each UBA’s paid-up share capital currently stands at N116 billion with shareholders’ funds growing to N3.3 trillion Volume 7 - 2019 | https://doi.org/10.3389/fchem.2019.00921 This article is part of the Research TopicProbing the Ubiquitin Landscape View all 19 articles Ubiquitination is a process in which a protein is modified by the covalent attachment of the C-terminal carboxylic acid of ubiquitin (Ub) to the ε-amine of lysine or N-terminal methionine residue of a substrate protein or another Ub molecule Each of the seven internal lysine residues and the N-terminal methionine residue of Ub can be linked to the C-terminus of another Ub moiety to form 8 distinct Ub linkages and the resulting differences in linkage types elicit different Ub signaling pathways Cellular responses are triggered when proteins containing ubiquitin-binding domains (UBDs) recognize and bind to specific polyUb linkage types To get more insight into the differences between polyUb chains all of the seven lysine-linked di-ubiquitin molecules (diUbs) were prepared and used as a model to study their structural conformations in solution using NMR spectroscopy fully 15N-labeled on the distal (N-terminal) Ub moiety and revealed their structural orientation with respect to the proximal Ub the diUb molecules exist in different conformations in solution with multiple conformations known to exist for K6- These multiple conformations allow structural flexibility in binding with UBDs thereby inducing unique responses One of the well-known but poorly understood UBD-Ub interaction is the recognition of K6 polyubiquitin by the ubiquitin-associated (UBA) domain of UBXN1 in the BRCA-mediated DNA repair pathway we establish here how a C-terminally extended UBA domain of UBXN1 confers specificity to K6 diUb while the non-extended version of the domain does not show any linkage preference We show that the two distinct conformations of K6 diUb that exist in solution converge into a single conformation upon binding to this extended form of the UBA domain of the UBXN1 protein It is likely that more of such extended UBA domains exist in nature and can contribute to linkage-specificity in Ub signaling The isotopically labeled diUb compounds described here and the use of NMR to study their interactions with relevant partner molecules will help accelerate our understanding of Ub signaling pathways Recognition of different polyUb chains by Ub binding domains (UBDs) is essential for stimulation of Ub signaling pathways These diUb molecules can be used to study the intermolecular interactions with other proteins involved in the ubiquitin pathway we demonstrate here the usefulness of these tools for gaining structural insights into the selective recognition of a unique Ub-binding domain (UBD) for a diUb linkage Structure of Ub (PDB: 1UBQ) showing the positions of all seven lysine residues (colored in blue) hydrophobic residues (colored in red) known to be involved in protein interactions are also highlighted Although it has been established that the UBA domain of UBXN1 can specifically recognize a K6 polyUb chain attached to the BRCA1 Ub ligase (Wu-Baer et al., 2010) the mode of interaction between the isolated UBA domain and the K6-Ub chain is largely unknown Using our synthetic diUbs and biophysical techniques we established how only an extended version of the UBA domain (UBAext1-52) of the UBXN1 protein binds selectively to K6 diUb To illustrate the interaction of K6 diUb with UBAext1-52 of the UBXN1 protein we monitored their titration by NMR and revealed which residues in the distal Ub of the K6 diUb molecule are important for this interaction Understanding this interaction between the extended UBA domain and K6 Ub chains will help in understanding the interaction preference over other Ub chains All chemicals were obtained from Sigma unless stated otherwise The ubiquitin-activating enzyme (UBA1) was recombinantly expressed with N-terminally fused hexahistidine tag (His6-tag) The enzyme was expressed in BL21 E.coli cells by adding 1 mM IPTG when the OD600 reached 0.6 followed by culturing the cells at 18°C overnight Cells were then sonicated in a lysis buffer containing 20 mM Tris-HCl 250 mM NaCl and 5 mM 2-Mercaptoethanol at pH 8 The supernatant was incubated with TALON® metal affinity resin and after two washing steps the UBA1 was eluted at 250 mM Imidazole concentration in the elution buffer The imidazole was removed from the buffer using 10 kDa cut-off spin columns (Millipore) The final concentration of the enzyme was measured using a Nanodrop™ 15N-enriched ubiquitin was expressed as an untagged protein using a pET2A expression system in BL21 E.coli cells in minimal essential medium The M9 minimal essential medium contained 50 mM Na2HPO4 After expression by autoinduction at 37°C overnight cells were spun down at 3,700 G for 10 min and resuspended in Milli-Q™ water containing protease inhibitor cocktail tablets Then the suspension was heated to 85°C for 30 min cooled down to room temperature and added with 0.3 mg DNase per 50 mL suspension along with 10 mM MgSO4 After heating again at 85°C for 30 min the cell lysate was spun down at 20,000 rcf The supernatant was purified by cation-exchange chromatography at 4°C using AKTA Unichromat 1500- “PRO” system (15 × 185 mm column packed with Workbeads™ 40 S) with two mobile phases: 50 mM NaOAc All fractions were checked on an SDS-PAGE gel The pure fractions collected from the cation-exchange column were re-purified over a C18 Atlantis preparative reverse-phase HPLC on a Shimadzu Prominence system using two mobile phases: A = 0.05% TFA in water and B = 0.05% TFA in CH3CN (Column temperature 40°C Typical ubiquitin yields were 80 mg/L of cell culture Native chemical ligation was performed by adding equal amounts of 15N Ub MESNa thioester and thiolysine-Ub to a final concentration of 50 mg/mL in 6 M Gnd.HCl 0.2 M sodium phosphate buffer pH 8 containing 100 mM MPAA and 50 mM TCEP the product was analyzed by LCMS and then diluted in desulphurization mix to a final concentration of 1 mg/ml protein (Diubiquitin) This mix contains 6 M Gnd.HCl 0.2 M sodium phosphate buffer pH 6.8 and 50 mM radical initiator VA-044 (2,2'-Azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride) the product was analyzed by LCMS and purified with RP-HPLC UBA(1-42) and UBA(ext1-52) peptides were synthesized at 2 μmol scales coupled with TAMRA on the N-terminus and purified by reversed-phase HPLC Stock concentrations of TAMRA-UBA peptides were measured using a standard curve of TAMRA-K-G from 0 to 800 nM in 20 mM Tris pH 7.6 and 150 mM NaCl The amino acid sequence of the UBA domain of the UBXN1 protein is as follows: The Ub and diUb molecules were analyzed by 12% Nu-PAGE SDS gel electrophoresis using MES buffer and Seablue plus 2® as a protein marker Isolated products with an expected molecular weight (MW) of 17,212 Da were observed as a single band in the gel at around 17 kDa The MW of the product were also confirmed by LC/MS using a Phenomenex Kinetex C18 (2.1 × 50 mm 2.6 μm) column (flow rate: 0.8 mL/min; runtime: 6 min; mobile phases: A = 1% CH3CN 0.1% formic acid in water and B = 1% water and 0.1% formic acid in CH3CN; column T = 40°C Protocol: 0–0.5 min: 5% B; 0.5–4 min: 5–95% B gradient; 4–5.5 min: 95% B) Final yields were measured after freeze-drying the product Samples were dissolved in DMSO and then diluted in NMR buffer containing 20 mM NaH2PO4 pH 6.8 to a final concentration of 4 μM Measurements were performed at 25°C using wavelengths ranging from 260 to 185 nm in a span of 100 m deg The scanning speed was 20 nm/min and measurements from 10 experiments were averaged the samples were subjected to BCA assay to determine actual concentrations Based on the observed values of CD measurements and concentration from BCA assay Freeze-dried ubiquitin and diubiquitin samples were dissolved in 5% DMSO (Biosolve) in Milli-Q® water and then redissolved in NMR buffer containing 20 mM NaPO4 pH 6.8 and 10% D2O samples were taken in 15 ml 3.5 kDa Millipore spin filter tubes and spun-washed with three volumes of NMR buffer until DMSO was almost completely removed (LC/MS analysis) Concentrated samples were diluted to 500 μL with NMR buffer and the final concentration was determined using BCA assay using ubiquitin as standard The pH was carefully measured using a Mettler TOLEDO pH probe All NMR studies were carried out on a Bruker 900 MHz spectrometer with a TCI cryoprobe processed and calibrated using standard methods Chemical Shift Perturbations (CSPs) were calculated by comparing the [1H 15N] HSQC spectra of mono Ub with that of each of the diUb molecules/ The CSP was calculated according to the following formula where ΔδH and ΔδN are the chemical shift differences for 1H and 15N The spectra of K6 diUb indicated two different co-existing conformations An “open conformation” was assigned based on similarity with the mono-Ub spectrum DiUbs were additionally purified by gel filtration on a HiLoad 16/600 superdex 75 pg column (GE Healthcare) in 20 mM Tris pH 7.6 and 150 mM NaCl The measurements were carried out in a FP binding buffer (20 mM Tris pH 7.6 the plates were briefly centrifuged for 1 min at 4°C and 500 G Read-out was performed on a PHERAstar plate reader (BMG labtech) using a TAMRA filter Statistical analyses were performed with GraphPad Prism 7 software using non-linear regression analysis [one site binding (hyperbola)] Microscale thermophoresis (MST) measurements were carried out using the synthetic TAMRA-UBAdomains in FP binding buffer Concentrations of K6 diUb ranged from 1.53 to 50 μM Samples were incubated for 30 min to allow binding and measured in hydrophobic capillaries on a Monolith NT.115 reader (NanoTemper Technologies Germany) using 30% LED and 40% IR-laser power The analysis was performed with GraphPad Prism 7 software using non-linear regression analysis [log (inhibitor) vs Diubiquitin molecules were synthesized using our previously established native chemical ligation procedure (Figure 2) (El Oualid et al., 2010) containing a δ-thiolysine building block instead of a lysine residue The distal 15N-Ub part was prepared by recombinant bacterial expression in 15N-ammonia enriched M9 minimal medium and converted to 15N-Ub MESNa thioester using UbE1 enzyme and MESNa The proximal and 15N-distal Ub precursors were ligated using native chemical ligation conditions The product was then subjected to chemical desulfurization using TCEP and VA-044 and finally purified by reversed-phase HPLC Schematic representation of the synthesis of 15N-labeled diUb 15N-Ub was expressed in a bacterial expression system; thiolysine (inset) containing Ub was synthesized from Fmoc-based SPPS 6 M Gnd.HCl; (iii) Ub-thiolysine after step (ii) overnight incubation; (v) buffer exchange to remove MPAA By NMR, a 2D [1H.15N] HSQC spectrum was obtained for 15N-Ub (Supplementary Figure S2). Although most of the signals were identified and assigned according to a previously reported data (Cornilescu et al., 1998) The data showed that monoUb is properly folded we also analyzed the NMR spectrum of all other diUb molecules CSPs calculated for all isopeptide linked diUbs by comparison of 15N-1H HSQC spectrum of mono-Ub with that of each of the 15N-labeled diUb Pictorial representations of each of the diUbs are shown (in each panel) the C-terminal residues in all diUbs show CSP due to their covalent bonding with the second unlabeled Ub indicating their possible interaction with the unlabeled proximal Ub The residues that show major CSP besides the C-terminal region are labeled K63 diUb shows the least interactions between the distal Ub and proximal Ub in line with the reported open conformations known for K63 linked Ub chains Comparing the overall CSPs of each of the diUbs measured in our NMR experiment and K48 diUb showed more perturbations than K27 diUb and Thr14 residues (“loop-in” conformation) which is in agreement with a compact diUb fold there is less effect from Ile36 and therefore less perturbations are seen in Thr12 and Thr14 residues (“loop-out” conformation) indicating that this K6 diUb conformation is less compact than the closed one but comparable to K48 diUb (A) Chemical shift perturbations calculated by comparing the 15N-1H spectrum of mono-Ub and the distally 15N-labeled K6-diUb (structural representation in inset) Although most of the signals are less affected and the C-terminal tail from Arg72 to Gly76 are all shifted significantly This indicates a change in the electronic environment of these residues which may be attributed to interactions with the unlabeled proximal-Ub Leu8 and Ile36 show a considerable migration relative to other residues signal doubling is observed for Asp32 and Ile36 in K6-diUb (B–E) NMR spectral regions showing 15N-1H peaks of Thr12 and Ile36 of K6 diUb (blue) compared with monoUb (red) We quantified the linkage specific binding of UBA(ext1-52) to K6 diUb with an approximate Kd of 1.43 ± 0.31 μM which was validated with an orthogonal technique called microscale thermophoresis (MST) and found a similar Kd value of 1.05 ± 0.12 μM Comparison of UBA domain sequences from different Ub binding proteins (A) Fluorescence polarization assay using a TAMRA-labeled UBXN1 UBA(ext1-52) domain and different concentrations of all 8 homotypical diUbs and monoUb (B) Microscale thermophoresis binding curve of K6 diUb to TAMRA-labeled UBA(ext1-52) from UBXN1 These experiments show the preference and tight binding of UBA(ext1-52) to K6 diUb Carefully analyzing the NMR structures of the isolated UBA domains of UBASH3A (pdb: 2CRN), UBASH3B (pdb: 2CPW), UBAC1 (pdb: 2DAI), USP5 UBA2 (pdb: 2DAK), and USP13 (pdb: 2LBC), we found that all three alpha-helices in the conventional UBA domain are structurally conserved whereas the first few residues of the 10 residues extending from the C-terminus starts from the last alpha-helix and then becomes largely unstructured (Figure 6) The C-terminal UBA extension in UBXN1 seemingly adds to K6 diubiquitin specificity and further research is needed to investigate whether this holds true for the other proteins containing this conserved C-terminal UBA extension and thereby establishing a functional role of this conserved motif (A) Structural comparisons of extended UBA domains The C-terminal extension of all the UBA domains mentioned here is found to be disordered (B) The UBA-domain containing proteins are color coded along with their respective PDB IDs (A) Unlabeled UBA(ext1-52) domain of UBXN1 was added in different concentrations to 15N-K6 diUb and the CSPs were monitored At a ratio of 4:1 (UBA(ext1–52) domain:K6 diUb) Other residues like Tyr 59 remain unchanged (B) X-ray crystal structure of a K6 diUb (PDB: 2XEW) showing the residues that were perturbed according to CSP Residues that shifted more are colored in red Residues whose signal disappeared upon addition of UBA(ext1-52) peptide are represented in purple (C) The same structure in figure (B) but showing the positions of side chains of the residues that were affected upon UBA(ext1-52) binding Several perturbed residues are found to be positioned on the surface away from proximal Ub suggesting that the binding to the UBA(ext1-52) domain has local effects but does not affect the structure of the entire distal Ub module Using the known X-ray crystal structure of K6 diUb, the interacting residues were mapped on the Ub surface (Figures 7B,C) It appears that the residues interacting with the extended UBA peptide are positioned away from the proximal Ub moiety The fact that the Leu8 residue of distal Ub is positioned at the interface between the distal Ub and proximal Ub moieties may suggest a dual role for this residue in interacting with both the proximal Ub and UBA peptide Both approaches have demonstrated the advantages of using chemoenzymatic procedures to make diUb molecules to study their structural dynamics related to functionality Although K48 chains are readily available for in-vitro studies K27 chains are impossible to make via biochemical strategies and recombinant enzymes Hence the chemical synthesis of these chains may develop into a valuable tool in identifying the interacting proteins and establish a mechanism of binding UBXN1 acts as a specific receptor protein and its UBA domain has been reported to be involved in chain recognition the exact mode of binding has not been shown using any biophysical methods so far we showed that to achieve binding to K6-linked ubiquitin instead of the canonical UBXN1 UBA (1-42) domain an extended version of the UBXN1 UBA domain we gain structural insight into the recognition of this elusive K6-specific ubiquitin-binding domain Our results suggest that different conformations of K6 chains are locked into one dominant conformation upon binding with the UBXN1 UBA(ext1-52) domain The additional 10 amino acids long C-terminal extension of the conventional UBA domain is found to be conserved among different proteins and is therefore important to study this in more detail in future experiments We have synthesized all isopeptide-linked distally 15N labeled diUb chains using native chemical ligation This allowed us to study their conformations in solution and the interactions of the distal Ub moiety with the proximal Ub moiety by NMR We also established that the additional C-terminal residues of the conventional UBA domain of UBXN1 protein are essential in binding specifically with K6 diUb molecule and K63 diUb exist in more than one conformation Sum of CSPs of residues in distal Ub of all diUbs excluding the C-terminal tail interactions which happen due to the proximity of isopeptide bond and not exclusively due to the interaction between the interface of the distal and proximal Ub revealing the crucial residues in the distal Ub of K6 diUb important for this interaction we demonstrate the applicability of these 15N labeled diUb chains as tools for gaining structural insights into the selective recognition of a unique UBD for a diUb linkage The datasets generated for this study are available on request to the corresponding author DS and RM prepared the Ub and diUb reagents for NMR measurements GT did the FP and MST measurements for UBA(ext1-52) and diUb interactions and KH provided valuable suggestions and ideas RB and HO supported the work with grants from NWO Work in the Ovaa lab was supported by NWO (VICI grant 724.013.002) NMR experiments were performed at the SONNMRLSF facility financially supported by an NWO-Groot Grant 175.107.301.10 FE and HO declare competing financial interests as shareholder of UbiQ Bio BV The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest We would like to thank Henk Hilkmann and Dris el Atmioui for providing synthetic ubiquitin mutants and ubiquitin-binding domains van der Heden van Noort and Stephan Scherpe for critical reading The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fchem.2019.00921/full#supplementary-material Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne Castañeda Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme Castañeda Linkage-specific conformational ensembles of non-canonical polyubiquitin chains Castañeda Linkage via K27 bestows ubiquitin chains with unique properties among polyubiquitins Castañeda and functional properties of k11-linked polyubiquitin chains Castañeda Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly Validation of protein structure from anisotropic carbonyl chemical shifts in a dilute liquid crystalline phase The differential modulation of USP activity by internal regulatory domains interactors and eight ubiquitin chain types The missing links to link ubiquitin: methods for the enzymatic production of polyubiquitin chains Monomer/oligomer quasi-racemic protein crystallography Myosin VI contains a compact structural motif that binds to ubiquitin chains Conformational dynamics of wild-type Lys-48-linked diubiquitin in solution The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway analysis and architecture of atypical ubiquitin chains The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome Breaking the chains: structure and function of the deubiquitinases Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations Total chemical synthesis of di-ubiquitin chains Structural and biochemical studies of the open state of Lys48-linked diubiquitin An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry Scalable synthesis of γ-thiolysine starting from lysine and a side by side comparison with δ-thiolysine in non-enzymatic ubiquitination Assembly and specific recognition of k29- and k33-linked polyubiquitin BRCA1: BARD1 induces the formation of conjugated ubiquitin structures in cells during DNA replication and repair Polymerization behavior of a bifunctional ubiquitin monomer as a function of the nucleophile site and folding conditions Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions The BRCA1 ubiquitin ligase and homologous recombination repair Quasi-racemic X-ray structures of K27-linked ubiquitin chains prepared by total chemical synthesis Structural assembly of multidomain proteins and protein complexes guided by the overall rotational diffusion tensor The UPS: a promising target for breast cancer treatment Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers Distinct functional surface regions on ubiquitin van der Heden van Noort Synthesis of poly-ubiquitin chains using a bifunctional ubiquitin monomer Various strategies of using residual dipolar couplings in NMR-driven protein docking: application to Lys48-linked di-ubiquitin and validation against 15N-relaxation data Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase PolyUbiquitin chain linkage topology selects the functions from the underlying binding landscape Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function Chaperoned ubiquitylation–crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13 Boelens R and Ovaa H (2020) Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1 Received: 11 September 2019; Accepted: 18 December 2019; Published: 22 January 2020 Copyright © 2020 Shahul Hameed, van Tilburg, Merkx, Flierman, Wienk, El Oualid, Hofmann, Boelens and Ovaa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Huib Ovaa, SC5PdmFhQGx1bWMubmw= †Present address: Remco Merkx, Medicines Evaluation Board, Utrecht, Netherlands Hans Wienk and Farid El Oualid, Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Mr Nwoke lamented that the alleged fraud had resulted in the blacklisting of his bank accounts and BVN from the banking system. Chinedu Nwoke, a customer of the United Bank for Africa (UBA), has sued the bank before the Federal High Court in Yenagoa over an unauthorised debit on his account, allegedly for a loan he did not take. Mr Nwoke is seeking redress over a purported COVID-19 loan of N700,000 from NIRSAL Microfinance Bank, which he claimed was fraudulently obtained using his bank verification number (BVN) without his knowledge. In his plea before the court, Mr Nwoke lamented that the alleged fraud, reportedly facilitated by the commercial bank, had resulted in the blacklisting of his bank accounts and BVN from the banking system, preventing him from accessing banking services. When the case came up for mention on Friday, Chinedu Iheanacho, counsel for the plaintiff, requested an adjournment to allow the court to begin hearing on the matter. The court, presided over by Justice Ayo Emmanuel, adjourned the case until March 31. The defendants, UBA and NISRAL Micro Finance Bank, were represented by Precious John. (adsbygoogle = window.adsbygoogle || []).push({}); The federal government has urged stakeholders in the agriculture and finance sectors in the West Africa region to leverage financing strategies to enhance agroecology practices “Katsina State is Atiku’s political base because it is his second home.” Although Mr Kanu’s lawyer, Kanu Agabi, also apologised on her behalf, the judge insisted that Ms Kanu would be barred from three proceedings. On Tuesday, Germany’s lower house of parliament convened for the election of Friedrich Merz as the country’s new chancellor. Saviour Enyiekere has assumed duty as the sixth executive chairman of the National Assembly Service Commission. A new pope will poll a two-thirds majority to emerge during the election process that will commence on Wednesday. A 20-year-old suspect has been nabbed in connection with an alleged armed robbery and murder. The statement said that under Mr Mustapha’s leadership, NBRDA had made notable strides in enhancing indigenous pharmaceutical production and advancing research capacity. © 2025 Peoples Gazette™ Limited. Bishop Kukah who is also the Pro-Chancellor of Federal University of Applied Sciences, Kachia, praised the Governor for going beyond the call of duty in making the varsity a reality. The Bishop gave these accolades when he and members of the university’s management paid a courtesy call on Governor Uba Sani at Sir Kashim Ibrahim House. The Pro-Chancellor disclosed that the Vice Chancellor, Professor Barnabas Qurix, has been visited relevant Ministries, Departments and Agencies of Government to facilitate the commencement of academic session. Kukah who said that the Federal University of Applied Science has built on the pioneering efforts of the former NOK University, promised that it will be one of the best in the country. According to him, the university will commence academic session in September but it has a few challenges that that will require the intervention of Kaduna State. The clergyman said that the university will need more infrastructure in the coming years and for this reason, it requires more land for expansion, adding that the school will also require access road. The Pro Chancellor also said that the Federal University of Applied Sciences will require utility vehicles and adequate security. Responding, Governor Uba Sani said that he has been working closely with Bishop Kukah on not just the University but on a number of issues, adding that the clergyman has been a pillar of support. According to the Governor, his doors are always open as he reiterated his commitment to deepen consultation amongst the diverse people of Kaduna State, irrespective of their ethno-religious or party affiliations. He said that his developmental strides in Kaduna State was made possible because of the prevailing peace, adding that there has never been any ethnic or religious crisis since he assumed office about two years ago. The Governor also argued that peace was achieved because of his administration’s policy of taking development to every part of the state, irrespective of whether or not the area voted for him. Governor Uba Sani disclosed that the Minister of Education promised that funds will be made available to the Federal University of Applied Sciences Kachia through TETFUND. He also promised to give the university more land, adding that the Managing Director of Kaduna State Roads Agency(KADRA) will assess the access road to the school for necessary action. On security, Governor Uba Sani noted that although there are a lot military formations in Kachia, he will collaborate with the Chief of Defence Staff to strengthen security. The Governor promised to sit down with members of his administration on the issue of utility vehicles. UPDATE NEWS: Nigerians can now earn US Dollars through domain flipping, buy domain names for cheap and have it resold to earn up to $15,000. Join Daily Trust WhatsApp Community For Quick Access To News and Happenings Around You. The endorsement was announced during a press briefing held in Kaduna the Kaduna State Commissioner for Public Works and Infrastructure said the decision to endorse Tinubu and Sani was borne out of the developmental strides recorded under their leadership He further noted that Governor Uba Sani’s administration had executed several infrastructural projects across the local government “There are ongoing road projects like Takalafiya to Soba Town and others within the LGA that will be completed by August We also have a skills acquisition centre the only one in Zone 1 as well as water projects expected to serve over 1,500 households,” he added Architect Hamza said the state had witnessed improvements under the current government “We are confident in this government and ready to support it to achieve its goals,” he declared He said many of their sons and daughters had been appointed into key positions in the current administration the former Chief Press Secretary to the Governor now the Executive Chairman of Soba LGA among others.” reaffirming the commitment of local stakeholders to the APC “There’s no room for the opposition in Soba and the state All stakeholders are united and will ensure that Governor Uba Sani and President Tinubu are reelected in 2027,” Shehu said The endorsement comes amid increasing political mobilization ahead of the next election cycle with APC leaders in Kaduna consolidating support across grassroots structures UPDATE NEWS: Nigerians can now earn US Dollars through domain flipping buy domain names for cheap and have it resold to earn up to $15,000 Join Daily Trust WhatsApp Community For Quick Access To News and Happenings Around You says the state has not experienced any ethno-religious or communal clashes over the past two years He attributed the absence of clashes in the state to the key role played by traditional leaders Speaking at Sir Kashim Ibrahim House during the distribution of 23 vehicles to the traditional leaders on Sunday Sani noted that they have been “working tirelessly sharing intelligence with security agents and maintaining close ties with our communities” “This is why our non-kinetic approach to addressing insecurity is effective Without the support of our traditional leaders we would not have achieved the security stability we enjoy in Kaduna State today,” he said Sani emphasised the importance of synergy between traditional institutions He said the vehicles distributed were intended to motivate the traditional leaders acknowledging their essential role in intelligence gathering and sharing The governor also commended Tajudeen Abbas provided by the Small and Medium Enterprises Development Agency of Nigeria (SMEDAN) are part of a fourth phase of a wider distribution plan He said the vehicles are not just symbolic but tools to help traditional rulers access all areas of their chiefdoms and emirates supporting their efforts to maintain peace and security Zebulon Agomuo Thanks for visiting UBA’s profit after tax rose by 26.14% to N766.6bn while gross earnings surged 53.6% to N3.19tn in 2024 The United Bank for Africa (UBA) Plc has released its audited financial results for the full year ended December 31 with all its major indicators witnessing significant improvement filed with the Nigerian Exchange Limited (NGx) on Monday showed an impressive rise in the bank’s profit after tax which went up by 26.14 percent to close the year at N766.6 billion up from N607.7 billion recorded at the end of the 2023 fiscal year The bank’s gross earnings also grew significantly from N2.08 trillion recorded at the end of the 2023 financial year to N3.19 trillion in the period under consideration the banks’ total assets also rose remarkably by 46.8 percent to close at N30.4 trillion in December 2024; signifying a milestone leap for the bank with the largest spread across the continent Despite the highly challenging global economic and business environment UBA recorded a profit before tax of N803.72 billion representing a 6.1 percent increase from N757.68 billion recorded at the end of the 2023 financial year UBA Group Shareholders’ Funds rose from N2.030 trillion as at December 2023 to close the 2024 financial year at N3.419 trillion achieving an impressive growth of 68.39 percent As a result of the impressive performance and in fulfilment of the promise made by the UBA Group Chairman to shareholders at the last Annual General Meeting the Bank proposed a final dividend of N3.00 kobo for every ordinary share of 50 kobo This brings the total dividend in the year to N5.00 The final dividend is subject to the ratification of the shareholders during its upcoming Annual General Meeting (AGM) stated that the 2024 financial performance demonstrates the bank’s continued focus on driving earnings growth expanding business operations and deepening market share “Our continued investment in our highly diversified global network allows UBA to deliver high quality while maintaining strong spreads and margins,” Alawuba highlighted “With total deposit increasing by 42.03 percent from N17.4 trillion in 2023 to N24.7 trillion and total assets hitting N30.4 trillion from N20.7 trillion the just-released results reflect broad-based growth across all core businesses and were achieved despite prevailing macroeconomic challenges The GMD expressed excitement at the marked improvement recorded in the bank’s core earnings profile as he explained that the profit is derived from high-quality income streams from funding intermediation now contributing 51.7 percent of Group revenue delivering diversification benefits and further boosting long-term shareholder value as we further explore strategic markets that align with our overall vision We are currently upgrading our business scope and authorization in France and considering other viable markets in the short to medium term,” Alawuba noted He pointed out the bank’s resolve to invest continuously in technology will collectively enhance our customers’ experience said the bank recorded triple-digit growth in net interest income resulting in remarkable improvement in net interest margin from 6.83 percent in 2023 to 9.02 percent while also recording strong double-digit growth in fee and commission income lines of 91.66 percent with shareholders’ funds growth of 68.4 percent to N3.42 trillion and a solid capital adequacy ratio of 31 percent and as we defensibly position the portfolio to navigate prevailing global and regional macroeconomic upheavals with strong provision coverage at 81 percent” He explained that as the bank navigates evolving risks its management remains focused on responsible growth delivering customer-focused value propositions whilst ensuring compliance with regulatory requirements in all jurisdictions UBA is one of the largest employers in the financial sector on the African continent with 25,000 employees group-wide and serving over 45 million customers globally Operating in twenty African countries and the United Kingdom commercial and institutional banking services leading financial inclusion and implementing cutting edge technology Easily access major global news with a strong focus on Africa we like to accentuate positive stories about Africa across all genres including Politics We broadcast 24 hours a day from our studios in London and New York and can be seen here in the UK and across Europe on the Sky platform (Sky channel 516) Freeview (Channel 136) as well as in the USA on the Centric channel and also on the Hot bird platform © 2023 Arise News - Part of the Arise Media Group is neither a complainant who seeks to hide under past failures to underperform nor a compliant leader who sustains retrogressive systems He is a realist who adequately appreciates challenges and strives to surmount them He not only avoids indulgence in escapism and skepticism both of which hinder attainment of tangible results but also commits himself to the expansion of scope of governance as a strategy for the delivery of democracy dividends As the member of the ninth Senate and current Governor of Kaduna State who also belongs to the ruling All Progressives Congress (APC) Uba Sani holds a position that is most critical to the peace and development of the North and therefore absolutely qualified to respond to the views of others on the region and the whole country either as a counter-argument or simple clarification respond to the issues being raised against the government of Kaduna State or even federal government by some political opponents therefore with the usual courage for which he is known that he acknowledges the predicaments of the North in particular and Nigeria in general but always strongly attributes the persistence of the identified problems to the prolonged neglect that the North suffered when most of those critics were in positions of authority Atiku Abubakar who was a very powerful vice president Nasir el-Rufai who was at various times the Director General of Bureau of Public Enterprises Minister of Federal Capital Territory and two-term Governor of Kaduna State as well as some others like them who have turned themselves into regular attackers of even the most well-intentioned policies of the APC-controlled government are The bluntness with which he speaks about the North’s woes depicting their magnitude and proffering solutions shows that he is prepared to tackle them to the extent that his position allows As he continuously and desirably exposes the complacency of most of those critics at the time a lot of the challenges surfaced or even their complicity in the noticeable escalation of same all Nigerians are speedily becoming more knowledgeable about the origin and dimensions of the deterioration By taking the blame for the underdevelopment of the North to the doorsteps of the critics and even advising them to apologise to the victims of their inactions Governor Sani has fully spoken the minds of all well-meaning Northerners It has already been widely realized that the succour for the North can be found only when such a realistic approach to the challenging issues is adopted and sustained most laudable is his effort to make a difference by introducing measures for the integration of the neglected persons in Kaduna State into the financial circles to enable them benefit from the empowerment programmes and other services offered by governmental and non-governmental institutions of millions of people of Kaduna State in the social register as a result of which financial services have now become accessible to them is a giant and most desirable step towards poverty reduction especially among the underprivileged members of the society · Shuaibu Gimi, shuaibugimi1966@gmail.com THISDAY is published by THISDAY NEWSPAPERS LTD. Nigeria with offices in 36 states of Nigeria the Federal Capital Territory and around the world It is Nigeria’s most authoritative news media available on all platforms for the political professional and diplomatic elite and broader middle classes while serving as the meeting point of new ideas culture and technology for the aspirationals and millennials The newspaper is a public trust dedicated to the pursuit of truth and reason covering a range of issues from breaking news to politics sports and community to the crossroads of people and society You can email us at: hello@thisdaylive.com or visit our contact us page This achievement positions NSF as one of only five certification bodies accredited to certify against UBA guidelines in the European Union outside of Germany This DAkkS accreditation to certify against UBA guidelines enables NSF to provide comprehensive certification services for materials and products that come into contact with drinking water This expansion of capabilities follows NSF’s recent opening of state-of-the-art laboratories in Rheda-Wiedenbrück and the addition of ASME and NSF/ANSI/CAN 60 and 61 standards testing in Europe “Securing DAkks accreditation to certify against UBA guidelines, coupled with our expanded European laboratory facilities, establishes NSF as the go-to accreditation body for the upcoming EU Drinking Water Directive standard which is in close alignment with the current UBA standard,” said David Platt “This milestone demonstrates our commitment to providing manufacturers with strategic advantages in the evolving European regulatory landscape and streamlining global market access.” The accreditation comes at a critical juncture as the industry prepares to implement the European Drinking Water Directive (DWD) safe drinking water for 448 million people across the EU covering all water intended for human consumption NSF’s enhanced capabilities offer manufacturers distinct advantages in preparing for these future requirements As one of the few certification bodies authorized to certify against UBA guidelines outside of Germany NSF provides a strategic pathway toward future EU harmonized standard compliance “Our Brussels headquarters now serves as a comprehensive certification hub offering global bundling capabilities and direct access to over 80 European certification experts from a single point of contact,” Platt explained “Our investments in Europe position NSF as the largest certification provider in the market capable of testing and certifying products against more than 500 national water standards enhancing both efficiency and readiness for the EU harmonized standard.” The expansion of in-house capabilities strengthens NSF as a European water certification industry leader Manufacturers can now access multilingual account managers across Europe Platt emphasized the alignment between the upcoming EU Drinking Water Directive standard and the current UBA standard “Manufacturers with UBA certification experience will have a significant advantage as the industry transitions to the new EU harmonized standard.” NSF’s achievement of DAkks accreditation to certify against UBA guidelines combined with its expanded European presence reinforces its commitment to water safety and quality improvement in the water industry As the European water product market evolves NSF stands ready to support manufacturers in meeting the highest quality and compliance standards For more information about certification to UBA guidelines and the future EU harmonized standard, visit NSF at the upcoming Aquatech and ISH trade shows or at nsf.org. 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