State Sen. Becca Rausch tops Dashe Videira to win fourth two-year termDaily News StaffState Sen. Becca Rausch, D-Needham, cruised to a fourth two-year term in the state Senate on Tuesday, defeating Republican Dashe Videira in the Norfolk Worcester & Middlesex District's general election Rausch earned 54,305 votes to Videira's 38,796 The district includes Milford in Worcester County; as well as Bellingham Plainville and Wrentham in Norfolk County; and Sherborn in Middlesex County While Rausch has worked on a number of issues from maternal health care to ensuring reproductive rights one of her major accomplishments is the development of a youth-friendly text help line Massachusetts Voter Guide: Rebecca Rausch vs. Dashe Videira for state Senate The “Hey Sam” line and offers support for those experiencing a mental health crisis or who just need to check in “It has been transformative,” Rausch told the Telegram & Gazette last month in an interview “The text line is helping save lives across the state.” is the Republican Party chair in her community Local Franklin activist Dashe Videira, has not shied away from political challenges, but even she was surprised when acquaintances from across the Norfolk, Worcester and Middlesex state senatorial district began suggesting that she run against unopposed Democrat incumbent, Senator Becca Rausch The suggestions quickly turned into a small organization of like-minded people determined to get Dashe on the November ballot That tiny organization has now turned into dozens of volunteers and above all trying to get Republican and Independent voters to the polls on Tuesday the date of the Massachusetts primary and the day after Labor Day to write in Dashe Videira's name and address on the currently blank "Senator in District Court" slot of the Republican Ballot If she gets enough write-ins or 'stickers' -- she will be pitted in November against Rausch who is seeking her fourth term on Beacon Hill Dashe describes herself as a dedicated wife and mother of four "passionately committed to the values embedded in America’s founding principles." she previously homeschooled her children in collaboration with local families in Franklin focusing on project-based learning and nature-based education through microschools Dashe earned her undergraduate degree in Psychology from Bridgewater State College and a graduate degree in Organizational Leadership from the University of the Rockies With a background in Human Resource Management she guided parents and children in managing thoughts fostering safe and nurturing home environments that supported spiritual Dashe empowers families to face societal pressures with confidence She advocates for the protection of God-given freedoms and encourages parents to take an active role in their children’s education Dashe teaches weekly early-morning Barre classes and works for the Archdiocese of Boston in Multicultural Ministries she enjoys reading about the Founding Fathers and environmental protection and health—especially when it comes to caring for "Mother Earth." Recently elected as Chair of the Franklin Republican Town Committee Dashe has been active in the committee for nearly three years She has also run as a candidate for School Committee and as a Republican candidate for the Governor’s Council in the Second District she seeks to involve more people in local politics and support candidates focused on practical the Franklin RTC actively participates in local events such as the Strawberry Stroll Dashe also serves as the Secretary of the Board for the Maximum Impact Foundation which supports local businesses through educational initiatives and grants to foster business growth and entrepreneurship she is a board member of Community Matters a nonprofit organization that provides a number of community-focused programs More information on Dashe is available on her website: www.voteforDashe.com (This story was updated because an earlier version included an inaccuracy.) Democrat Rebecca Rausch is seeking a fourth term as state senator for the Norfolk Rausch has been a Senate member for six years While she has worked on a number of issues The “Hey Sam” line She was an architect of the state’s plastics reduction act a measure that would limit single-use plastics such as grocery shopping bags single-serving water bottles and food containers “The plastics industry emits four times the amount of greenhouse gases every year than the airlines industry,” Rausch said The act intersects with her work to address the state’s water pollution problems including testing wells and water systems for PFAS Rausch said she was wowed by an exhibit she was invited to attend by the administration at the Massachusetts Museum of Contemporary Art Artist Robin Frohardt created “The Plastic Bag Store,” an installation resembling a supermarket where all the products are made of plastic bags “Art has a phenomenal way of waking up the brain,” Rausch said explaining that the installation and accompanying video were “mind-blowing.” Rausch hopes to create an arts laureate program for the state The measure is included in the stalled economic development bill passed by both branches but still awaiting reconciliation “It could be a boon for the state’s creative economy and tourism,” Rausch said visits schools to discuss civics and delivers state aid and grants to her communities including state funding to Sherborn and Wrentham as they celebrate big anniversaries Videira has a background in psychology and organizational leadership and has worked in human resources for a large company. She also works in the multicultural ministry for the Archdiocese of Boston. The Republican Party chair in her community, Videira has run for School Committee in Franklin aiming to promote alternative education models based on her experience with micro schools and home schooling. She also made a run for Governor’s Council in 2022. The mother of four young children whom she has home-schooled and enrolled in private schools, Videira approaches education from project-based learning. “Children should eat organic foods,” Videira said. She praises school programs that focus on the outdoors, gardening and appreciation of nature. In her runs for office, Videira found there was a great divide between elected officials and the community at large. “I want to create bridges, create a place where residents can vent their frustrations and criticisms of the Franklin Town Council and state legislators,” Videira said. “I want to be the voice of reason.” The first item on her agenda if elected is to tackle the issue of mental health, to find ways to solve the crisis rather than normalize it. “The crisis is not being solved. There are more and more people diagnosed with mental health challenges,” Videira said. “We need more community engagement to understand the struggles. We can’t just throw money at the problem.” Also high on her agenda is addressing what she believes is the overreach of the state government, the proposed Community Immunity Act, co-sponsored by Rausch, that would among other things require data collection and public reporting of immunization rates for children participating in programs that are open to the public. Videira said the act would would make medical exemptions more difficult to obtain and erode parental rights by allowing minors to consent to preventative care, including vaccines, without parental involvement. Above, Dashe Videira: "My jaw dropped to the floor." The Wednesday evening Franklin Town Council meeting began with torrent of citizen comments and ended more than two hours later with soul-searching comments and some that were concerned and conciliatory from councilors. First up with impassioned remarks was resident Dashe Videira, a candidate for state senate. She noted that she had attended the state rep debate in Medway on Tuesday Oct. 8, and was initially forced to wait outside with others while an overcrowding issues was address “All I was doing was just standing there and the thought that somebody could [come up to me and] tell me that I didn't have the right to live, and that I was running a hate campaign, and then to top it off, called me a vile human.” Videira said “my jaw dropped to the floor,” and that she was very thankful for someone physically being there to help` diminish where it could have gone.' "I'm very thankful that my husband was not there, because I think a very poor situation could have gotten even uglier,” she added. Videira said the man making the remarks was the current chair of the Franklin Cultural Commission and also a former town councilor. She also faulted a current town councilor near her in the crowd, for not intervening or speaking out.  Having been portrayed on the Vote Franklin Facebook page in a ‘meme’ that appeared to show her as a school shooter and also describing her as being like the Boston Strangler, Videira said that the ‘group’ involved with the page is itself a hate group and needs to be shut down. All together the river of comments took about half an hour to run its course (including a separate critique of the Town's failure to act on its looming fiscal crisis from Susan Dewsnap) and was followed by a more staid meeting, discussing a range of topics, including the town “branding” initiative. “If I truly witnessed somebody badgering and threatening another human being, regardless of political differences, I would have stepped in,” he added. He went on to talk about the interactions he has with many people around town in the context of business, children and sports and that we are all part of Franklin and need to work to treat each other with respect. Neither Patrick Sheridan nor Cobi Frongillo commented.Town manager Jamie Hellen was asked by a councilor whether something could be done regarding the verbal attack and he said he was unfamiliar with the matter until the start of the meeting and couldn’t do anything unless he heard from the police. Moderate rain, with a high of 57 and low of 51 degrees. Overcast in the morning, mist overnight. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Above, Quincy City Council President Ian Cain, who is endorsing Franklin's Dashe Videira for State Senate. Videira also previously received an endorsement from Alex Hagerty, President of the Boston Log Cabin Republicans, an organization representing LGBT conservatives and their allies. Although Rausch is further ahead in total cash on hand, the two candidates raised similar amounts in September, surprising for the underdog who announced her campaign earlier that month. October receipts won’t be made public on the state’s Office of Campaign and Political Finance until November.Most critically, the Videira campaign believes it has momentum, having attracted scores of motivated volunteers and is leveraging strong word of mouth communication, according to the candidate. Following her Saturday event, Videira tweeted that she is “excited to be running for State Senate,” and is dedicated to fostering unity and creating a community where everyone belongs. “Together, we can create opportunities for individuals, small businesses, and families to thrive while ensuring accountability in our government,” she wrote. Volume 12 - 2018 | https://doi.org/10.3389/fnins.2018.00381 This article is part of the Research TopicMitochondrial Dysfunction and NeurodegenerationView all 16 articles Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting about 6.3 million people worldwide PD is characterized by the progressive degeneration of dopaminergic neurons in the Substantia nigra pars compacta The cellular mechanisms underlying dopaminergic cell death in PD are still not fully understood oxidative stress and inflammation are strongly implicated in the pathogenesis of both familial and sporadic PD cases together with age-dependent insufficient endogenous scavengers and quality control systems lead to cellular overload of dysfunctional proteins Such injuries accumulate with time and may lead to mitochondrial dysfunction and exacerbated inflammatory responses we will discuss how PD-linked protein mutations impaired quality control mechanisms and sugar metabolism lead to up-regulated abnormal post-translational modifications in proteins Abnormal glycation and glycosylation seem to be more common than previously thought in PD and may underlie mitochondria-induced oxidative stress and inflammation in a feed-forward mechanism the stress-induced post-translational modifications that directly affect parkin and/or its substrates deeply impairing its ability to regulate mitochondrial dynamics or to suppress inflammation will also be discussed these represent still unexplored deleterious mechanisms implicated in neurodegeneration in PD which may be used for a more in-depth knowledge of the pathogenic mechanisms Genes and loci associated with autosomal recessive (AR) or autosomal dominant (AD) Parkinsonism reduced species of oxygen are responsible for the oxidative damage of lipids proteins and nucleic acids including the mitochondrial components themselves predisposing to apoptotic cell death Mitochondria are highly dynamic organelles, that continually fuse and divide, and the balance between fusion and fission determines the size, shape, number and function of these organelles (Bose and Beal, 2016) Damaged and/or obsolete mitochondria are selectively removed by a quality control mechanism known as mitochondrial autophagy or mitophagy Coordination between clearance of damaged mitochondria and mitochondrial biogenesis is essential in the maintenance of a healthy mitochondrial pool and cellular homeostasis mitophagy is essential in mitochondrial turnover regulation by adjusting the amount of organelles accordingly to metabolic requirements of cells It is generally accepted that mitochondrial biogenesis depends upon fusion events while fission is assumed to isolate damaged organelles that can then be targeted for degradation the fine-tuned regulation of mitophagy seems to be impaired in PD since this mechanism is regulated by parkin and by the serine/threonine protein phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and mutations on these proteins are known to be related with rare familial forms of PD Parkin and/or PINK1 loss of function may lead to the accumulation of injured mitochondria which will contribute to increased production of oxidative stress that may possibly underlie PD pathogenesis contributing to further oxidative stress and neuron degeneration further reinforcing the involvement of mitochondrial dysfunction in PD pathogenesis Impairment of UPS in PD triggers a cycle of cell-damaging events including accumulation of misfolded proteins aggregation of α-synuclein and mitochondrial dysfunction fine tune regulation of autophagy seems to be impaired in PD contributing to the accumulation of toxic species and misfolded proteins The disproportional increase in the concentration of misfolded proteins and toxic species has critical consequences on the normal functioning of cells in particular of organelles such as mitochondria and ER These data collectively suggest that in PD the UPR is up-regulated and this may account for the accumulation of misfolded proteins and aggregation of α-synuclein and subsequently to neuronal loss possibly linking aberrant glycosylation with neuropathological events once activated by injured neurons microglia can itself become a donor source of toxic factors causing injuries to nearby neurons in a process designated by neuroinflammation will induce additional microglial activation and may be an important process that drives and exacerbates the progressive neurodegeneration after the initial stimulus In PD decreased parkin activity leads to increased accumulation of dysfunctional mitochondria as well as increased antigen presentation at the surface of these organelles triggering the recruitment and activation of microglia and peripheral infiltrating inflammatory cells Mitochondria antigen presentation pathway dependent on PINK1 and parkin provides an elegant way to connect mitochondrial dynamics and immunologic pathways in PD favoring the hypothesis of systemic mitochondrial defects in PD and indicating a possible link between mitochondrial dysfunction and inflammation The observation of periphery immune cells in CNS of PD patients goes beyond the local involvement of microglia and neuroinflammation but also associates the whole immune system in the progression of this disease Together these observations indicate the importance of central and peripheral immunity reactions in PD, keeping the current question whether inflammation is involved in triggering the disease, or occurs instead as a consequence. Recently, autoimmune diseases or peripheral infections are considered by some authors as a risk factor for the development of PD (Witoelar et al., 2017) in a current view of the disease as being a multisystem pathology and not only confined to the CNS both these monosaccharides may also act as ROS scavengers shifting oxidative phosphorylation to glycolysis as a protective mechanism activated in early stages of the disease The pathway of protein glycation and AGE formation Endogenous glycating agents include glucose and reactive triose intermediates of energy metabolism The formation of AGEs occurs spontaneously by non-enzymatic reactions in a process designated by Maillard reaction The early stage of this reaction usually occurs rapidly (hours to days) while the advanced stage of AGE formation is thought to take weeks to months to occur further corroborating the contribution of AGEs for PD development and/or progression in PD the scenario may involve accumulation of RAGE ligands due to environmental cell conditions that favor up-regulated biosynthesis and/or impaired endogenous clearance systems Hyperglycemia and oxidative stress may up-regulate the Maillard reaction with increased formation of AGEs in brain cells (1) AGEs can either bind to membrane RAGE (mRAGE) at the cell surface of microglia and/or neurons triggering NF-κB activation and subsequent expression of pro-inflammatory mediators and RAGE (2) Glycation can also directly affect the function of proteins namely α-synuclein favoring its accumulation and aggregation (3) circulating AGEs may bind to soluble RAGE receptors (sRAGE) that do not control any intracellular pathway cells are endowed with efficient endogenous systems for detoxication against AGEs namely glyoxalase-I and -II that constitute the main systems responsible for the metabolization of AGEs in a pathway dependent on glutathione (5) Together these data strongly implicate RAGE expression and activation in PD and are corroborated by the findings in several experimental models of the disease further reinforcing the involvement of this receptor in PD pathologic mechanisms indicating that this may not be useful as a biomarker for the disease these observations indicate that the downstream signaling cascades of RAGE and the self-perpetuating expression of RAGE contribute to the damaging effect of HMGB1 in PD increased cell surface expression of RAGE receptors in PD allows the binding of more glycated α-synuclein α-synuclein accumulation and neuronal cell death linking together the onset of these two pathologies Additionally, MGO may also interfere with the UPS, which in the context of PD, plays a major role in the clearance of misfolded α-synuclein (Ciechanover and Kwon, 2017). The failure of the UPS may arise due to the fact that ubiquitin is a target for MGO, which impairs its ability to conjugate with its target proteins (Uchiki et al., 2012) this promotes a self-perpetuating reaction further contributing to α-synuclein aggregation and impairment of proteasome function probably contributing to the deleterious effects of glycation in PD and therefore the propensity for an increased formation of MGO or stress-induced DJ-1 dysfunction appear to be associated with mitochondrial impairment and increased levels of MGO although the exact mechanism still needs to be fully understood but to our knowledge this information is lacking in PD glycation and the underlying mechanisms of RAGE activation seem to represent important therapeutic targets in PD All cells and a significant number of macromolecules in our body display covalently attached sugars, named “glycans.” These glycans present a great structural variability, according to the involved building blocks (the monosaccharides) and the bond-type. In addition, alterations of the physiological condition of the cells and differentiation stage can easily alter their structures (Lowe and Marth, 2003; Haltiwanger and Lowe, 2004) The major classes are typically defined according to the nature and linkage to the conjugate a protein or lipid (glycoprotein or glycolipid) Different classes of glycans modify proteins and lipids and have distinct biosynthetic pathways This figure refers the major glycan classes expressed by human cells and that are described in the text It also depicts their different biosynthetic steps and their localization for initiation Glycans can be attached to proteins via N-linkage to Asparagine (N) The N-glycans share a common pentasaccharide core region (highlighted in the figure in a gray box) that can be further diversified N-glycans are initiated by the en-bloc transfer of a large preformed precursor glycan to a newly synthesized glycoprotein Glycans can be attached to proteins via O-glycosylation Common O-glycans are initiated by GalNAc O-linked to S/T in a polypeptide chain O-glycans are further extended with the sequential addition of other monosaccharides Glycans linked to a lipid moiety ceramide are named glycolipids or glycosphingolipids These are initiated by the addition of glucose to ceramide on the outer face of the ER-Golgi compartments and the glycan is then flipped into the lumen to be extended The glycosylphosphatidylinositol (GPI)-anchored proteins are glycoproteins linked to a phosphatidylinositol GPI-anchored proteins are initiated by the en-bloc transfer of a large preformed precursor glycan to a newly synthesized glycoprotein Proteoglycans are glycoproteins where glycosaminoglycans are attached to the proteins Glycosaminoglycans are linear polymers containing disaccharide unit repeats that can be attached to proteins or exist in free form Intracellular proteins can also be modified with O-GlcNAc O-GlcNAcylation is the covalent link of a GlcNAc to a serine or threonine (S/T) It is distinct from all other common forms of protein glycosylation since it occurs exclusively within the nucleus and cytoplasm and it is not further elongated or modified A distinct O-glycosylation is the O-linked N-acetylglucosamine (GlcNAc), occurring independently of the ER-Golgi pathway, and consisting in the single addition of a monosaccharide GlcNAc to nucleus and cytoplasm proteins (Figure 3) is a glycan linked through glucose or galactose to the terminal primary hydroxyl group of the lipid moiety ceramide As these ceramides consist of a long chain base (sphingosine) and a fatty acid the glycolipids are also named glycosphingolipids (GSLs) consists of an anionic glycolipid that contains one or several residues of the monosaccharide sialic acid Glycosylation influences not only the native conformation of the protein but also specific properties such as solubility It has also a role in cell to cell communication intracellular molecular signaling pathways and in particular the modulation of the immune response as an indicator of disease stages or for defining therapeutic treatments Different classes of glycans implicated in the pathogenesis of Parkinson’s disease inflammatory milieu and ER stress reduce sialic acid content within neuronal N-glycans This leads to loss of microglia Siglec receptors recognition and also complement activation Altered glycolipids content and glycosylation of neuroprotective proteins such as TREM2 and DAT can lead to decreased activation or expression of such proteins O-GlcNAcylation of α-synuclein and other mitochondrial proteins was also observed in PD that leads to protein dysfunction enabling molecular transfer from peripheral blood This could further explain the relationship between the peripheral alterations in the glycome and exacerbation and spreading of CNS pathogenic mechanisms with subsequent increased neuronal death and abnormal sugar metabolism This can decrease the concentration of brain type specific N-glycans and gangliosides linking the deleterious effects of glycation and aberrant glycosylation We still know very little about the role of glycosylation of specific proteins in PD, although it appears that the glycome may be different between patients and age-matched healthy individuals (Russell et al., 2017). Interestingly, two putative N-glycosylation sites were found in the V-type ligand domain of mature RAGE protein (Neeper et al., 1992; Kislinger et al., 1999) While the structural/functional basis underlying the ability of RAGE to bind a multitude of ligands was not revealed yet one possibility is that these N-glycosylation sites may influence RAGE signaling by modulating its binding to different molecules and thus modifying the intracellular pathways activated by this receptor in different cellular contexts These results highlight the neuroprotective role of native parkin through a less well-known mechanism that involves its ability to maintain proper dopamine uptake ubiquitinates and targets for degradation misfolded abnormally glycosylated DAT and favors the proper membrane localization of this transporter contributing to an efficient dopamine recycling and reduction of dopamine-associated toxicity toward neighboring cells we focused on the established concepts of neuroinflammation and abnormal glucose metabolism in PD linking them to mitochondrial dysfunction and emerging fields of research that take into account current discoveries suggesting that glycation and abnormal glycosylation may underlie the development and/or progression of this disease Mechanisms involved in dopaminergic neuron cell death in PD Mitochondria dysfunction in PD can be caused by mutations in PD-linked proteins (e.g. herbicides) or age-induced depletion of endogenous antioxidant defense mechanisms (1) ROS levels and oxidative stress increase and accumulate overcoming the endogenous antioxidant capacity Mitochondria dysfunction and oxidative stress may trigger glycation that in turn will affect several proteins tend to be misfolded and to form insoluble aggregates (2) This is further potentiated by impairment of several quality control pathways in PD namely proteasome-dependent protein degradation (3) Protein aggregates and oxidative stress activate microglia and trigger the neuroinflammatory response within the brain (4) malfunction of ER resident enzymes responsible for glycosylation of target proteins (5) Impairment of this mechanism may underlie improper protein function as well as abnormal cell–cell contacts With PD progression BBB permeability increases and peripheral T cells invade the CNS (6) contributing to the accumulation of pro-inflammatory mediators and further activating microglia (neuro)inflammation may damage mitochondria entering a vicious cycle of deleterious effects that ultimately lead to dopaminergic cell death (7) Understanding the glycosylation pattern of glycoproteins which are affected by either genetic or environmental cellular stressors in PD can be a promising approach for the discovery of novel biomarkers to assist an easy prognosis only a few glyco-PD studies have been performed and our knowledge of glycan functions in the context of PD is still limited The characterization of the general N-glycome as well as specific glycosylated membrane proteins in peripheral blood cells from PD patients and healthy controls will reveal the potential contribution of aberrant glycosylation in the cellular dysfunctions leading to neurodegeneration in PD the large-scale serum glycomics of a variety of stages of PD patients could accelerate the discovery of novel class of biomarkers and molecular targets toward the development of the diagnostic and therapeutic agents for this disease This work was supported by Fundação para a Ciência e a Tecnologia (FCT) grant number UID/DTP/ 04138/2013 (iMed.ULisboa) and by the Applied Molecular Biosciences Unit- UCIBIO which is financed by national funds from FCT (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728) The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The authors gratefully acknowledge 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of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review Citation: Videira PAQ and Castro-Caldas M (2018) Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson’s Disease Copyright © 2018 Videira and Castro-Caldas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Margarida Castro-Caldas, bWNhc3Ryb2NhbGRhc0BmZi51bGlzYm9hLnB0 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Dining The western section of Midtown Alley has its share of reputable foodservice establishments: Pappy’s It’s now time for the eastern part to get in on the action, according to developer Jassen Johnson of Renaissance Development Associates and Tower Real Estate Group Louis Dining In and Dining Out newsletters to stay up-to-date on the local restaurant and culinary scene who previously worked with Misha Sampson and Ceaira Jackson at Bait in the Central West End before launching Nexus “I originally was just going to work for them [at Nexus],” McIntosh says “and then Ceaira suggested I do my own thing in the space next door.” McIntosh is a longtime industry professional who over the years “became friends with a lot of fellow industry people like wine experts and craft cocktail bartenders who want to help me These people really want me to succeed… It’s wonderful.” Vidiera (Portugese for “grapevine”) will offer a slightly less traditional take on the wine bar and the lounge seating will be comfortable and I can sit here for hours,’” McIntosh says adding that the vibe will aim to be “a mashup of 33 Wine Bar and Brennan’s…a mix of the wine knowledge you pick up at 33 with the coziness you experience at Brennan’s.” Behind the bar is a dispensing system for glass wines (to better control quality and freshness). McIntosh prefers California wines but says other regions and countries will be represented Bottles of wine will also be available as well as local beers and cocktails (made with fresh-squeezed juices and handmade syrups) named after movie stars some of whom will be depicted in black-and-white photos on the walls—part of the “sexy “nothing loud and crazy,” McIntosh says and accouterments featured on the charcuterie boards which will venture beyond basic salami and feature “funkier ingredients and bresaola.” Burrata and other wine-friendly fare will round out the small-plates menu Guests will enter Vidiera off Beaumont Street where some sidewalk seating will be available. There will be additional outdoor seating on a covered interior garden space that will be shared among the other tenants Start your mornings with a fresh take on the day’s top local news from Sarah Fenske and Ryan Krull Our award-winning content brings readers revealing profiles Start your mornings with a fresh take on the day’s top local news Switch to the dark mode that's kinder on your eyes at night time Switch to the light mode that's kinder on your eyes at day time by 2022-01-15, 6:46 PMupdated 2022-01-16, 5:15 PM João Bruno Videira: Website | Facebook | Instagram Report Enter your account data and we will send you a link to reset your password To use social login you have to agree with the storage and handling of your data by this website Here you'll find all collections you've created before This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Republican candidates and supporters at the Franklin polls Tuesday (at right Dashe Videira running for state senate and Charles Bailey running for state rep.) Below The Massachusetts Primary yesterday produced a relatively light turnout but did have some consequences locally and statewide Republicans chose Marine veteran and attorney John Deaton to challenge Democrat US Senator Elizabeth Warren in November local activist and Republican Town Committee Chair chose to run a late write-in campaign to get on the November ballot to oppose incumber Democrat State Senator Becca Rausch of the Norfolk In this she appears to have been successful scoring nearly 400 write-ins just in Franklin a four-way contest to run in the November election for District 2 Governor’s Council The results in Medway and Franklin closely matched those district wide totals candidate for Massachusetts Governor’s Council today received the endorsement of Chris Doughty who recently fought a hard campaign to be the Republican candidate for Massachusetts Governor I came to know Dashe Videira as a highly principled and deeply motivated mother of four and as a hard-working activist on my campaign I know she cares deeply about the people in our communities and will fight to make government more accountable and transparent,” said Doughty “As the next person to represent District 2 on the Governor’s Council and decency are what gets people appointed to judgeships -- not political connections,” he added The Governor’s Council has a vital role in shaping the Massachusetts judiciary – the judges and magistrates that decide civil and criminal matters that affect all of us For more information, visit https://www.votefordashe.com Earlier versions of this post had innaccurate transcription of some words and phrases including "shut up," which a closer examination of the recording reveals to have been misheard Angela Spring asks "what is a protected student?"There was supposed to be a regular School Committee Meeting Tuesday evening Instead there was a lengthy public comment segment followed by a report from the Committee’s high school representatives that devolved into shouts screams and tears and ended with a temporary adjournment Some minutes later the meeting resumed as per normal And at the very end things turned sentimental and a bit maudlin as “retiring” Committee members bid farewell and got their well-deserved accolades A large contingent of parents and citizens turned out for the Citizen Comment part of the meeting The first up was Angela Spring: I would like some clarification and a clear definition on who is considered a protected student in the Franklin School District What prompted this question is a statement that was made in my daughter's class a couple of weeks back a male student came back from the bathroom and relate to the entire class and the teacher that there was a female crying in the bathroom The teacher was quick to respond and said actually it is a male student crying and I hope that you did not say anything to this student because they are a protected student The teacher continued and said that it was not a female crying but a male student and hope that they were not bullied because they are a protected student this student would face severe punishment because they are in that category my daughter asked who's protected who is not how are they protected?” Spring noted that she had asked the question of the Principal but felt the answer was unsatisfying and hoped the School Committee would be able to clarify for her identifying himself as the husband of School Committee candidate Dashe Videira He explained that key parts of her written statement to last week’s candidate’s night had been omitted namely the quotes from “The Bluest Eye” by Toni Morrison a book used as a text in some high school classes Videira read a passage which described in details lurid enough to impress Potter Stewart the internal mental processes of a sexually conflicted man who decides to rape little girls and frequently seductive,” the passage concluded Videira asked rhetorically,” does anybody here support this type of language I think parents have a right to determine when and if their children are subjected to this type of language.” The next 15 minutes or so brought more citizen comments Linda LeBlanc from Skyline drive also brought a book that she said was in the high school library and included a graphic description of the rape of an 11-year-old girl by her father as well as lengthy discussions of premarital sexual relations and bestiality; if you made this book verbatim into a movie no one under the age of 18 would be allowed to see it,” said LeBlanc challenged the audience: “Why does an English teacher Director of Curriculum or the superintendent allow high school children to read this,” she asked from October Drive started on a positive note “”I know you have a good heart.” Then she recapped her multi-year effort to get children more time for lunch and recess – asserting that no other town in the area has such brief time slots for these important activities She also complained about a fourth grade “puberty talk” that actually is a detailed sex ed program she asserted that a book “The Hate You Give”—intended for teenage readers -- is being assigned to fifth graders in Franklin despite graphic sexual language and descriptions of drug use “You need to speak up about these books and these things that are inappropriate in this town have got to stop,” she said and Jackie Maciel closed out comments; Benson revisiting the lack of leadership on masking from the Committee Dickerson expressed concern that mandatory vaccines will be imposed on even young children in the new year despite a large body of evidence regarding bad reactions and deaths decrying indoctrination and lack of democratic processes in the school Bergen turned attention to the high school representatives the treasurer of the class of 2022 and also part of the theatre company at the school She provided updates on the recent prom and on the upcoming musical Mamma Mia as well as a `trunk or treat’ event this Friday She went on to discuss several other matters including National Honor Society and then began to refer to the topics raised in Citizens Comments I know some friends from Medway high school who they recently reached the 80% vaccination marks and the high school had personally decided that they would not allow masks to be optional until they received 50% of students to sign up for regular testing at the school I just wanted to mention that what surrounding towns were doing just because I think that might be something interesting to consider.. Then she noted that “seniors are starting to feel a lot of stress coming back to school for their first kind of semi normal school year since technically freshman year was our only normal year of school.” I just wanted to make a comment...teachers have been enforcing masks like very heavily although lots of students are not really listening...we've just heard about even though students who are fully vaccinated they will still be respecting the mask mandate and wearing them above their nose the proper way all day.” “I think it's important that we all are very considerate of the people around us and the choices that everyone makes because whether or not you believe that masks work I think it's important to just consider the well-being and safety of others because though the statistics of people dying from vaccines might be very shocking and horrifying that I think the statistics of people dying from COVID-19 are a bit more horrifying After a short interlude when Shaw spoke about the junior class I don't know if some of you remember but last time I was here representing the high school for the school committee I spoke something that I wrote about the so-called classes that are protected in the school such as homosexuals and I just want to share I know it's not appropriate that the school committee responds to community citizen comments I think what should be known is that at the high school level at the beginning of every school year outlining what protected classes are in the school That protected classes was what they're called And we know that because we're in the United States of America what is not clear about school environment is that though everyone is said to be protected there's obviously that stereotype that everyone in theater is gay you can say that it's pretty true because a lot of us are gay and it's somewhere where we can be comfortable But when kids are coming to theater every single day Or I got called a racial slur in the hall today It's become something that we're so numb to that it becomes a joke I think it's important to understand that yes But being someone who is Caucasian is not something that you're getting bullied about I am being personally attacked in school about this [more voices from elsewhere in the room] “It’s disgusting that you can look me in the eye and say I am not being oppressed Bergen [to the speaker at the back of the room]: Please sit down or you will be asked to leave Bergen: We will ask for a short adjournment Atwood: There is no such thing as a gay agenda After summoning the police, the meeting resumed several minutes later.Watch for reportage on the rest of the meeting tomorrow – or watch the meeting on Youtube. Below, Mackenzie Atwood and Shaw Downing at the moment the meeting was recessed. Volume 5 - 2023 | https://doi.org/10.3389/fdgth.2023.1216357 Digital Health is a subject of extensive discourse when considering its current and future significance This significance arises from a convergence of various factors including the escalating capabilities and cost-effectiveness of computing and communication technology coupled with the mounting demands and challenges faced by healthcare systems when studied collectively with the purpose of addressing tangible real-world issues holds the potential to generate substantial outcomes that greatly influence the provision of clinical and social care thereby enhancing the overall well-being of both individuals and populations in this paper we propose a collaborative approach where the most relevant stakeholders—health and care professionals citizens and companies—work together to develop and validate innovative digital solutions for health and care We have called this approach of value co-creation the Collaborative Ecosystem and we focus specifically on the potential development of the Regional Ecosystem for Collaborative Innovation in Digital Health and Care and the envisioned implications of its implementation in economic and social dimensions The prevailing paradigm dictates that an increasing number of individuals experience poor health as a result of rapid lifestyle changes in contemporary society The modern lifestyle provides easier access to energy-rich food while reducing opportunities for physical exertion Maintaining good health now necessitates conscious efforts that extend beyond occupational activities or obtaining sustenance deliberate choices must be made regarding diet Lifestyle-related illnesses exert a substantial burden on healthcare budgets in western economies, accounting for approximately 70% of expenditure. Moreover, the absolute value of these budgets is projected to escalate rapidly due to the aging population in many countries (5) Considering that healthcare budgets are already strained to their limits it is evident that an alternative approach is urgently required The advent of Digital Health holds the promise of facilitating improved self-care practices and averting or delaying the onset of severe diseases offering a potential solution to these challenges it is undeniable that we currently face new urgent challenges posed by the global COVID-19 pandemic we have to provide citizens with solutions that allow them to maintain their health even when access to medical care (in person) is unavailable We wish to do so by “bringing care home” meaning helping people access information about health-related topics even with so many necessary lifestyle changes helping them manage their pre-existing medical conditions (especially relevant for those suffering from chronic diseases that need constant monitoring) In this paper we propose a collaborative approach The definition of Digital Health is rather complex and authors include or exclude different aspects the term “Digital Health” encompasses a comprehensive range of elements these components empower individuals to make well-informed decisions regarding their health and track their progress to identify the most effective approaches for their unique circumstances Based on emerging technologies for data gathering and sharing including the ground-breaking advances in the Internet of things artificial intelligence and machine learning digital innovation emerges in various forms including direct-to-consumer wellness products mobile applications (apps) and wearable technology and innovative service models like telemedicine/telehealth Individuals can now share their biological and behavioural data with carefully chosen people and organizations within the healthcare system allowing them to anticipate and address their health and care requirements Strategic design and cost-effective implementation of Digital Health innovations have the potential to enhance the “effectiveness, accessibility, and resilience of health and social care systems”. By doing so, they enable the emergence of novel service delivery business models (6) According to the Committee on Quality of Health Care in America, the healthcare industry has consistently underinvested in appropriate use of information technology and it lags behind comparable knowledge-intensive industries by about 15 years (7) Digital Health presents a promising growth avenue for numerous companies This is evidenced by the strong interest shown by global technology giants who have allocated substantial investments in research and development specifically focused on health-related initiatives It is recognized that digital transformation of health and social care will be disruptive. Investment in the digital health sector is enormous, with a lot of new solutions coming to the market. For instance, after the explosion of the mobile health market in the COVID-19 pandemic, there were more than 350.000 health apps available to users with more than 250 health apps added daily to app stores (8) We are still facing the problem of enrolling patients and healthcare professionals in using digital solutions which is one of the main barriers to the implementation of new digital services/products in real life single-disciplinary approaches in academia and clinical settings is necessary Embracing the potential of these technologies to revolutionize healthcare and enhance well-being calls for a fresh perspective on science and health research methods Open innovation is defined as “the use of purposive inflows and outflows of knowledge to accelerate internal innovation, and expand the markets for external use of innovation, respectively. [This paradigm] assumes that firms can and should use external ideas as well as internal ideas, and internal and external paths to market, as they look to advance their technology” (10) Building from the aforementioned concept of individual empowerment in the management of one's own health we believe that there are two key concepts that define a common thread behind all actions on Open Innovation in the health and care sector: “Validation” and “User-centred” Validation is the process of gathering evidence and learnings around business ideas through experimentation and user testing Notwithstanding the irreplaceable role of fundamental research we can no longer afford to create solutions for the sake of novelty generation new solutions must place users at the core of the development process if they wish to successfully enter the market and reach their intended goal we have in recent years witnessed the rise of Testbeds and Living Labs Living Labs are defined as “user-centred, open innovation ecosystems based on a systematic user co-creation approach integrating research and innovation processes in real life communities and settings” (11) Living Labs prioritize citizen engagement in the innovation process thereby demonstrating their capacity to effectively adapt new concepts and solutions to the distinct requirements and creative potentials of local contexts and cultures There are several references to the importance of Living Labs in the EU's strategy policy documents (12–15) highlighting the relevance of human and social aspects for better design and implementation of Research It becomes clear from this excerpt that these kinds of initiatives are at the top of the priority list for European Union-supported projects being aware of the existing demand for the increase of Digital Health solutions and the support that can be expected from the European Union guidelines for the upcoming years we have conceptualized a new approach for the development of the health and care ecosystem of innovation and service provision the increase in life expectancy and sedentary lifestyles have led to an alarming raise in the prevalence of chronic diseases and multi-morbidities In order to lighten the burden on healthcare systems we need to empower citizens to take upon themselves to manage their conditions autonomously This will also bring us closer to the ultimate goal of having truly personalized healthcare as everyone will be able to knowingly select and employ whatever solutions fit their individual needs the best The best set of tools to achieve this is Digital Health If we wish to ensure the success of this paradigm shift we need to make sure that the technologies being developed are (a) fit to the real challenges of end-users and (b) user-friendly to allow for significant adherence from the target market our vision is to improve health and wellbeing for everyone by accelerating the development and adoption of appropriate Digital Health solutions we aim to be at the forefront of research in co-creation validation and adherence promotion of disruptive innovative solutions that provide digital and objective data accessible to both caregivers and patients which can trigger a cultural shift in patient-clinician interactions leading to more balanced relationships with shared decision-making and the democratization of care We need to find ways to co-create value for all relevant actors in society—whether it is economical value for companies and healthcare providers social and scientific value for health and care professionals or personal value—through personalized Health and Quality of Life improvement and individual empowerment—for patients and citizens Our positioning and strategy for the pursuit of this goal is to develop activities to contribute to digital transformation of health and care, acting at 3 different levels (entrepreneurs, health and social care professionals, and citizens/patients), as shown in Figure 1 The collaborative ecosystem activities and their impact on relevant stakeholders For each of these key stakeholder groups we have identified the main challenge and the expected long-term impact of our intervention - Citizens and Patients—lack of digital and health literacy leading to a lack of trust in the solutions - Entrepreneurs—lack of awareness of the benefits of co-creation; insufficient knowledge or misconceptions regarding the right methodologies for end-user engagement - Health and Social Care Professionals—lack of digital literacy; lack of incentives for innovation we come to the core of our approach: the Collaborative Ecosystem we wish to not only engage the stakeholders in the innovation process chain but also to generate knowledge that allows us to develop the best methodologies and protocols to do so and mobilize formal and informal training initiatives that guarantee the success of the solutions and user long term adherence Allow us to deconstruct the concept of a Collaborative Ecosystem “Ecosystem” elicits the analogy to the biologic concept of the “system consisting of all the organisms and the physical environment with which they interact” We bring this into fruition in our context by taking in consideration all the relevant players features and uniqueness of our particular reality This also means that the composition of the Collaborative Ecosystem is dynamic and adaptative to the changes in the context implies that we are bringing together different segments of society and institutions in a way in which their respective strengths and expertise complementarily come together to generate value for the whole Our proposition for a pilot implementation of this concept needs and existing abilities of the region encompassing the North of Portugal and the neighbouring Galicia region of Spain is called the Regional Ecosystem for Collaborative Innovation in Digital Health and Care We have designed this initiative to include academic partners (such as Universities and research centres) regional authorities and business creation organizations (such as incubators/science and technology parks) The main pillars of activity of the Collaborative Ecosystem are: segment and take advantage of the most comprehensive pool of end-users Research—shed new light on the factors surrounding technology acceptance and uptake by users; develop new interfaces and user-machine interactions to enhance usability; and create improved methodologies and guidelines for open innovation Living Lab activities—co-creation and validation of Digital Health solutions Training—in Digital skills for citizens and health and care professionals By building an ecosystem attractive to European industry and policy-makers the Collaborative Ecosystem has the potential to develop value-based business models to open and scale-up the market for digital solutions It can also provide key recommendations for the far-reaching deployment of innovative digital health and care solutions supporting and extending healthy and independent living at the European level The Collaborative Ecosystem partners recognise an opportunity to achieve beyond state-of-the-art applied knowledge and digital solutions to improve the quality of life leading to a better and improved framework for sustaining healthy lives be unfeasible and too costly to pursue individually particularly for business-oriented partners (care service providers and technology providers) The Collaborative Ecosystem proposal is organised to facilitate and require strong interdisciplinary knowledge sharing among researchers Combining technical and social sciences disciplines this Collaborative Ecosystem is positioned to produce outputs based on active contributions of all partners Within the Euroregion of North of Portugal-Galicia this could be the first time such an endeavour is taken at a major scale with so many relevant players in the health and social sectors coming together to create added-value solutions To launch our endeavour, we will draw lessons from analogous initiatives throughout Europe. Namely, we have identified Trentino eHealth Ecosystem (16) Based upon this initiative's findings we have realised that having a multitude of very different stakeholders in our ecosystem is not only not an hinderance but actually an added-value to the success of the ecosystem the interaction between technology/service suppliers and patients generates value co-creation and innovation “if new resources new uses of technology and new institutions are created” By putting in place the conditions for this exchange to happen in a sustainable manner over time we are guaranteeing that a new way of service delivery in health and care is being created with sustainable value co-creation for all the parties involved the main challenge in developing an initiative that actually generates value for its users that is an obstacle to the adoption of technology Another example of a network-approach (adjacent to the ecosystem we describe) is Service Design for Value Networks, and specifically its application to the design the Portuguese National Healthcare Record service (17) normal approaches to value networks are based on a univocal relation between provider and users (even if these are different segments whether or not connected—a many-to-one design) rather than parity approach of interdependent actors—many-to-many This is a challenge when we plan to implement this type of model on a complex web of relationships such as the health and care sector Several other authors (18, 19) when referring to the main challenges to the successful implementation of a Digital Health Ecosystems reiterate that the main challenges to be faced are the lack of digital health literacy self-management and collaboration in “the prevention and alleviation of potential problems” The latter is especially true when it comes to the need to keep stakeholders engaged in the long-term Short-term sporadic joint actions are relatively common but in order to maintain an ecosystem viable and functioning as such we need that the multiple actors continue to interact with each other towards the development of common goals have integrated in our approach some tools to prevent these pitfalls such as: (a) the implementation of training in Digital and Health Literacy for both citizens and healthcare professionals; (b) the creation of a partnership where representatives of the different sectors of society and stakeholders in the creation of value in Digital Health have equal opportunity to shape the activities of the ecosystem; (c) the establishment if the Collaborative Ecosystem as an umbrella organization that will be able to leverage its joint resources the added value of the collaboration and the visibility of its dimension to raise funding that can then be used by other actors in the region thus ensuring their engagement in the joint development efforts The next steps for the launch of the Collaborative Ecosystem are the creation of this new organization where the main actors identified (academic partners regional authorities and business creation organizations) will act as shareholders accountability and commitment to the common goals above individual institutional policies and priorities The new umbrella organization will be the main representative of the interests of the different stakeholder groups and will be mandated to put in place the activities previously described There are several support and funding schemes both at national and European level that can be leveraged for the launch of the initiative we intend on being fully sustainable and self-funded This choice is made following our experience in witnessing that initiatives supported by calls for public funding seldom continue to exist past the funding period for lack of incentives for the implementing consortia to pursue long-term sustainability That is why we plan to have the founding partners commit their own resources and develop profitable activities in order to ensure the independency of the Collaborative Ecosystem from any contextual and policy paradigms It is expected that the Collaborative Ecosystem contributes in the short term to improve the (1) collaborative living-lab activities on Digital Health innovation (2) number of validated digital solutions developed in co-creation with end-users as a way to improve acceptance and adherence to technology; (3) end-user awareness to health and wellbeing issues and digital technology use; (4) citizens' knowledge about the current available solutions for the challenges they face; (5) technology readiness level of the research produced by academia; (6) partnerships between academia and industry In the medium-term we expect to improve (1) the sense of empowerment and ownership of digital solutions by end-users; (2) the market's confidence in the available products/solutions boosting the economical relevance of Digital Health solutions; (3) the competitiveness in the region through the attraction of foreign business In the long-term Collaborative Ecosystems are the way to best improve the (1) overall quality of life of citizens through the adoption of Digital Health innovative solutions; (2) public involvement in research by influencing research topics and directions towards more applied and solution driven projects; (3) companies' and researchers' accountability as transparency is present throughout the entire innovation chain Digital Health innovation will be prioritized through dedicated bodies and mechanisms for governance This will be translated into national Digital Health strategies or similar strategic frameworks These strategies will be incorporated into national health strategies and actively employed to steer advancements and expedite progress towards the health-related objectives outlined in the Sustainable Development Goals they will play a crucial role in facilitating the digital transformation of health systems The predicted outlasting legacy of the Collaborative Ecosystem will be the establishment adoption and application of minimum standards for Digital Health solutions; the implementation of a mechanism facilitating personalized feedback for assessing the efficacy of Digital Health tools and services; and the development of comprehensive guidance lines on personalized medicine The original contributions presented in the study are included in the article further inquiries can be directed to the corresponding author JC wrote the first draft of the manuscript All authors contributed to conception and design of the study All authors contributed to the article and approved the submitted version All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 1. European Commission. The 2018 ageing report: economic and budgetary projections for the EU member states (2016-2070) (2018). Available at: https://ec.europa.eu/info/publications/economy-finance/2018-ageing-report-economic-and-budgetary-projections-eu-member-states-2016-2070_en 2. United Nations. World population ageing 2019 highlights (ST/ESA/SER.A/430) (2019). Available at: https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf 3. World Health Organization. World report on ageing and health (2015). Available at: https://www.who.int/ageing/events/world-report-2015-launch/en/ Digital health is a cultural transformation of traditional healthcare CrossRef Full Text | Google Scholar 5. UK Government’s Foresight Programme. Tackling obesities: future choices (2007). Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/287937/07-1184x-tackling-obesities-future-choices-report.pdf The impact of eHealth on the quality and safety of health care: a systematic overview CrossRef Full Text | Google Scholar Institute of Medicine (US) Committee on Quality of Health Care in America Crossing the quality chasm: A new health system for the 21st century 8. IQVIA Institute for Human Data Science. The growing value of digital health: evidence and impact on human health and the healthcare system (2021). Available at: https://www.iqvia.com/-/media/iqvia/pdfs/institute-reports/the-growing-value-of-digital-health.pdf 9. World Health Organization. Global diffusion of eHealth: making universal health coverage achievable. World Health Organization (2018). Available at: https://www.who.int/goe/publications/global_diffusion/en/ Open innovation: a new paradigm for understanding industrial innovation Open innovation: Researching a new paradigm 11. European Network of Living Labs. The living labs methodology handbook (2007). Available at: https://www.living-labs.net/documentation/2007_living_labs_methodology_handbook.pdf 12. Helsinki Manifesto, Finland’s EU Presidency (2006). Available at: https://www.scribd.com/document/290101063/Helsinki-Manifesto-201106 14. European Parliament. Digital agenda for Europe (2020). Available at: https://www.europarl.europa.eu/factsheets/en/sheet/64/digital-agenda-for-europe 15. European Commission, Joint Research Centre. Smart specialisation platform (n.d.). Available at: https://s3platform.jrc.ec.europa.eu/what-is-smart-specialisation- Sustainable value co-creation and digital health: the case of trentino eHealth ecosystem CrossRef Full Text | Google Scholar Service design for value networks: enabling value cocreation interactions in healthcare CrossRef Full Text | Google Scholar One digital health: a unified framework for future health ecosystems Exploring the use of digital health innovations to improve health equity: an international perspective CrossRef Full Text | Google Scholar Midão L and Costa E (2023) Changing the paradigm in health and care services: modern value chains using open innovation for the creation of new digital health solutions Received: 3 May 2023; Accepted: 14 June 2023;Published: 26 June 2023 © 2023 Carrilho, Videira, Campos, Midão and Costa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited *Correspondence: Joana Carrilho amNhcnJpbGhvQGZmLnVwLnB0 Statement from Dashe Videira on Senator Becca Rausch's Refusal to Debate I am deeply disappointed by Senator Becca Rausch's refusal to participate in an open debate when Senator Rausch was running for her seat faced significant criticism for declining to engage in a debate with her The League of Women Voters issued a combined statement at that time “When candidates refuse to participate in opportunities to help their future constituents learn more about them this is a loss for voters.” Senator Rausch rallied support around this issue emphasizing how crucial it is for voters to engage with candidates she is repeating the very behavior she once opposed by refusing to debate me Despite the League of Women Voters approving a forum and the Tri-County Chamber of Commerce requesting a debate Senator Rausch has declined to participate "Becca Rausch is unable to participate in the forum prior to the start of early voting so we will not be holding a State Senator forum this year." when asked directly by a constituent if she would debate her opponent “I have always engaged in debates and forums; unfortunately this year my schedule fills up literal months in advance.” She further added “There is just no more time; everything is booked all the way through pretty much to Thanksgiving at this stage of the game.” This refusal to debate is not just an avoidance of accountability; it reflects a troubling focus on national politics rather than the pressing issues that families face here in our district While Senator Rausch appears to be focused on canvassing for federal figures like Senators Warren and Vice President Kamala Harris’s presidential run It is crucial for voters to hear directly from their elected officials about their positions and priorities Debates serve as an important platform for our constituents' voices to be heard I am fully prepared and eager to participate in a debate and I urge Senator Rausch to put her constituents first For more information about my campaign, please visit VoteforDashe.com. Candidate for the Norfolk, Worcester, Middlesex District Image: Sen Becca Rausch at Franklin Senior Center,  Sept 24, 2024 Join the conversation You can save this article by registering for free here. Or sign-in if you have an account The basic material of the hockey helmets used today — from NHL pros down to Atom-league youngsters — has changed very little in nearly 80 years They’re made with a vinyl nitrile shell and foam liner that absorb the energy of a collision blow or puck strike before that energy reaches the head Subscribe now to read the latest news in your city and across Canada Create an account or sign in to continue with your reading experience We apologize, but this video has failed to load.Try refreshing your browser, ortap here to see other videos from our team.Play VideoArticle contentThe first vinyl nitrile helmets saw action in the 1940s the main innovations have been in their shape and thickness and via add-ons such as visors and cages size of players and potential for head injury have all gone up markedly By signing up you consent to receive the above newsletter from Postmedia Network Inc The next issue of Top Stories will soon be in your inbox Interested in more newsletters? Browse here. there have been major advances in engineered materials that could be applied to protective headgear it’s as if hockey players are driving used Chevys in a Formula 1 race The main reason is that regulations currently set a very high bar for approving new engineering materials for mass manufacturing for products made with new materials to be approved has only recently received the OK for widespread use in consumer products manufacturers and regulators want to know that engineered materials perform consistently and are 100-per-cent effective and safe But our processes for testing materials have changed little since the 18th century They typically involve establishing trust through brute statistics You test the entire material and its manufacturing process multiple times If you want confidence a helmet has a one-in-10,000 chance of not working when hit by a puck you fire a puck at it 10,000 times and see what happens you go back to the drawing-board and order 10,000 more pucks it is now possible to test and validate new material in a fraction of the time and cost by shifting from a brute-force statistical method to a 21st century You don’t need to do 10,000 tests to have a one-in-10,000 level of confidence as long as you have the insight and platform to accurately determine the right types of tests for determining the material performs as intended Such a validation platform already exists and has successfully tested new material for advanced armour its physical qualities are mapped using AI tools the platform can accurately simulate how it can withstand the force of a puck (in the case of a helmet) or an ammunition strike (in the case of armour) Think of it this way: We already know the energy produced by a violent puck strike in hockey The validation platform accurately analyzes how well a new material can absorb that energy based on its molecular composition Making use of this knowledge can save time and money in testing improved materials Physical tests will still be necessary to observe any anomalies But this new framework can reduce the number of such tests from 10,000 to 100 It can also determine if a new material does not meet expected standards which allows inventors to pivot with minimal waste of time and money The only thing missing from this recipe for more rapid materials development is a consensus among regulators that a new validation platform should be a priority lighter and safer hockey helmets for our kids and thousands of other innovations streamlining the validation of new materials would be a good place for policymakers to focus their attention transmission or republication strictly prohibited This website uses cookies to personalize your content (including ads), and allows us to analyze our traffic. 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By continuing to use our site, you agree to our Terms of Use and Privacy Policy You can manage saved articles in your account Self-taught fiber artist João Bruno Videira explores the innumerable creative possibilities of woolen yarn in his creative practice by interlocking colorful threads in harmonious geometric patterns My mother used to be a teacher but she was very passionate about making Arraiolos rugs a traditional kind of carpet we have in Portugal And the wool I use is exactly the same,” Videira tells My Modern Met “Its characteristics—resistance and color—make it special and distinct from other natural fibers And my work reflects this difference.” From wool “paintings” that resemble abstract art to yarn-covered benches and chairs Videira finds many ways to incorporate his craftsmanship into furniture and design “Nature and its multitude of forms obviously play a crucial role in terms of creative stimulus,” he continues This inspiration is most notable in the wool stones and series of trees and roots geometry is something that seduces me and can be seen in all of my work.” You can keep up to date with Videira's latest sculptures by following him on Instagram João Bruno Videira: Website | Facebook | Instagram Japanese Artist Crafts Adorable Crocheted Bonsai Trees Olympian Tom Daley Releases His Own Line of Cozy Knitting Kits Artist Reuses Yarn and Discarded Plastics To Create Crocheted Art About the Climate Crisis Want to advertise with us? Visit My Modern Met Media Celebrating creativity and promoting a positive culture by spotlighting the best sides of humanity—from the lighthearted and fun to the thought-provoking and enlightening Young soccer players are often intrigued with playing in Europe vice-president of player personnel for the New England Revolution from taking Videira in the second round of the MLS draft "We were aware of his desire to go to Europe," says Burns who was once a Marlborough High School star And that's how Milford native Videira became a Rev "I was on trial for a few teams in England," says the 23-year-old center midfielder recommended him to Hamilton in the Scottish League A quad injury sidelined him for 3 1/2 weeks "They were set with their lineup," says Videira "We got the feeling he wanted to play here He's going to be joining us from the get-go." The Revs start practicing Feb Videira took up soccer as a 5-year-old in Milford "My father coached my teams when I was very young The pace of his soccer life was picking up speed and moved on to the Boston Bolts when he was a high school freshman at Mount St He transferred to Noble & Greenough "for academics and soccer when Videira was 16 and playing for the Boston Bulldogs Before he'd become fully engaged with soccer Videira enjoyed playing baseball and basketball with friends But I signed up for indoor soccer at the same time." He's never looked back Charles he played soccer from grades seven to nine "We won the state championship two years." "the league (Independent School League) was more competitive." He captained Nobles his senior year I didn't know if I wanted to be close to home or go far away." He graduated with a sociology degree last year "My freshman year we were ranked number one for a while and went to the Final Four My sophomore and junior years we won the ACC tournament and got to the Elite 8." One year in the postseason the Blue Devils led UCLA 2-0 but lost Duke didn't even make it to the postseason "Before I left for Europe I spoke to (Nicol) and told him I'd like to give it a try over there Burns never stopped tracking Videira's career "I saw him play a lot for his club team and followed his career at Duke." "he'll be the only player who can drive from his house," says Burns « Back Michael Videira was sure in position to do so last December coming off a sterling junior season for the Duke men’s soccer team The Milford native had just led the Blue Devils to the Atlantic Coast Conference regular season and tournament crowns and was named the tourney Most Valuable Player to boot he almost guided Duke into the College Cup semifinals — the NCAA Division I version of the Final Four — but lost to UCLA in overtime in the Elite Eight and was named to academic and playing All-American squads the resume was stacked; the pro waters were beckoning He could’ve followed in the footsteps of the Revolution’s Michael Parkhurst — take the bonus money and join the class of Generation adidas young stars who head to Major League Soccer after their junior years But something kept him tied to the Durham campus Even though he would’ve been a top five pick in the MLS SuperDraft in January the mind-set was to stay and get my degree," said Videira so I set my mind to stay about three weeks after (the season ended)." With Videira returning to head a senior class a baker’s dozen strong the Blue Devils are one of the top title contenders in the country They’re ranked fourth in the NSCAA/adidas preseason poll second in the College Soccer News rankings and No There’s no doubt that John Rennie’s club is deep and talented but there’s also no doubt that Videira is the cornerstone of this gilded squad "He has certainly become a dominant college player I wouldn’t trade him for any other midfielder in the ACC the 29-year Blue Devil head coach who last week announced this is his last year at the helm "Mike can be explosive at different times and just take over a game," added Rennie There’s so few players who have the ability to do that and therefore make a difference and win a game." Videira takes over from his attacking midfield position similar to what he did at nearby Noble & Greenough School in Dedham leading the Bulldogs to a share of the NEPSAC Class A crown his junior year he was in the center of a five-man midfield but he has been atop a four-man grouping at Duke for three years He followed that up with three goals and nine assists as a sophomore then tallied a career-best eight goals to go with nine assists last fall He’s now 6-foot-1 and 170 pounds — plenty of size and strength to play one of the most demanding positions on the field and everyone’s pumped up for this season," said Videira who was pleased to finally get two-a-days in the Carolina heat out of the way last week he made his lone trip to New England this year but he might as well be wearing a red dress in a bullfighter’s ring now Everyone who plays Duke knows who they have to stop "I’ve prepared the same way I always prepare," he said "I always have good aspirations to do well and for us to go deep (in the NCAA tournament) Everyone is coming out with that same mind-set Thoughts of a pro career once his season wraps up Videira is of Portuguese descent and has a European passport So no work permit troubles await him if he chooses to play overseas — joining his former ACC and ISL rival Charlie Davies who now plays for Hammarby of the Swedish Premier League thanks to help from Harvard coach John Kerr spending three weeks with Millwall FC of the English Coca-Cola Championship If he chooses to enter the 2008 MLS SuperDraft Revs assistant coach Paul Mariner has already spoke about how much he loves Videira’s game And with his local pedigree on top of his talent I caught a couple reserve games this summer to see (former teammates) Chris (Loftus) and Kyle (Helton) "I think MLS is doing great right now," added Videira "I think the league is equally as strong as some leagues (in Europe) I would enjoy playing here as much as playing there I just have to see what’s the best situation for me at the end of the season." Maybe that resume will have a national title and a Hermann Trophy at the top of the page and become the best soccer talent to come out of this area since Marlborough’s Mike Burns there’s a little bit of pressure; I sort of see it," said Videira a student at the Instituto Superior de Engenharia do Porto (ISEP) assumed the position of Chairman of the Board of the National Youth Council committing himself to embracing a new challenge as leader of the organization to provide continuity to the work carried out by the current management with a particular emphasis on the purposes with which AFS - Intercultura Portugal submitted itself to suffrage arguing that Marcelo Rebelo de Sousa’s invitation to join the Civil House “should greatly honour the new generations and the National Youth Council itself as it is recognition of the agenda that this body has been defending on behalf of young people “with regard to their access to decision-making centres as well as the youthful quality of this country " João Pedro Videira is today one of the main faces of student associations as an imperative of the future of his generation His associative path began in 2014 at the ISEP Student Association the year in which he was also Chairman of the General Assembly of the National Federation of Higher Education Polytechnic Student Associations he was also a member of the Polytechnic of Porto General Council from 2015 to 2020 he was awarded the P.PORTO Distinguished Services Medal in 2020 he is elected president of the Academic Federation of Porto (FAP) in elections marked by the total renewal of the federation's management bodies The two terms in which he was president are marked mainly by the student accommodation project Bairro Académico aimed at the challenges of the society of the future and by the implementation of a strong sustainability agenda in the federation the National Youth Council has taken on the portfolio of International Relations and the area of Innovation while Member of the Board of Directors of FNAEESP An active collaborator in various CNJ activities João Pedro Videira was one of the ambassadors of the national meeting of this structure participated in several actions with leaders of political parties in the Colóquios (RE)Partidos and participated in the campaign for the last European elections having organized meetings and promoted debates with candidates for these elections especially within the framework of the European Union where we will seek to increase our influence before political decision-makers especially with regards to employability and youth emancipation" - explains the current president - "we have a vision for the country and this is what moves us with a legal statute approved by the Assembly of the Republic the National Youth Council is the representative platform for youth organizations nationwide covering the most diverse expressions of youth associations (cultural As a structure that carries out its mission in the interests of all Portuguese young people recognized by the State as a privileged partner in terms of youth policies the CNJ is an important platform for dialogue assuming the role of interlocutor before the constituted powers claiming the right to consultation on all matters concerning the Portuguese youth in general Intranet Candidaturas DOMUS Marca Documentos Públicos Portal Emprego Gestão Académica Central de Ajuda +351 225 571 000Chamada para a rede fixa nacionalF Message Invalid character found in the request target [/news/detail/en/N17BW0thPC?0-1.IBehaviorListener.0-confirmDialog\u0026category\u003dTourism_and_Culture ] The valid characters are defined in RFC 7230 and RFC 3986 Description The server cannot or will not process the request due to something that is perceived to be a client error (e.g. Note The full stack trace of the root cause is available in the server logs RCI pays a tribute to Father Benjamim Videira Pires This number of the Review of Culturefeatures a compilation of articles devoted to this remarkable figure and to the leading role he played in Macanese society for half a century Maria de Lurdes Escaleira and Jorge de Abreu Arrimar       An article on the categorization of the Early Literature of Macao and the role of Tang Xianzu introduces a new chapter devoted to literature where as well the novel Os Doresby Henrique de Senna Fernandes serves as a subject of study for the two academics to produce an insight into Macao The Asian discovery of the Great South Land and the sandalwood trade Timor-Macao are issues discussed by Geoffrey Gunn in the chapter that concludes this number Macao Archives and Kun Iam Ecumenical Centre It is also available for consultation at the Central Library at the Archive of Macao and at the libraries of Macao universities.