Collisions resulting in serious injuries to four people closed highways near Cantley and Smiths Falls on Friday afternoon Subscribe now to read the latest news in your city and across Canada Create an account or sign in to continue with your reading experience Police from the MRC des Collines-de-l’Outaouais said a 53-year-old man was transported to hospital after the motorcycle he was riding collided with a truck on Highway 307 in the Cantley area around 3 p.m Highway 307 was closed in both directions between Ste-Élizabeth and Mont-Cascades roads by police announced the reopening of the roadway at about 7:30 p.m By signing up you consent to receive the above newsletter from Postmedia Network Inc The next issue of The Evening Citizen will soon be in your inbox Interested in more newsletters? The investigation of the collision was continuing the Ontario Provincial Police reported that three people had been taken to hospital with serious injuries following a two-vehicle crash on Highway 15 north of Smiths Falls Highway 15 was closed in both directions between Ferguson Tetlock and Kelly Jordan roads until late Friday evening “Please plan alternate routes between Smiths Falls and Carleton Place,” an updated OPP post said transmission or republication strictly prohibited This website uses cookies to personalize your content (including ads), and allows us to analyze our traffic. Read more about cookies here. By continuing to use our site, you agree to our Terms of Use and Privacy Policy You can manage saved articles in your account OttawaNewsQuebec Highway 307 to be closed into Friday evening near Cantley following crashBy Ted RaymondPublished: July 19, 2024 at 3:12PM EDT Twitter feed ©2025 BellMedia All Rights Reserved Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Shirley was born to Ward and Edith Armstead in Roane County She is survived by her husband of 42 years Stanley Cantley; daughters Theresa (Rick) Dudding and Angela Flinner; son Michael (Jessica) Cantley; granddaughters Susan (Eric) McMillion and Celeste Cantley; grandsons Austin Cantley and Brice (Naomi) Stinnett; great-grandchildren Johnathon McMillion and Godrick Stinnett; Great-great granddaughters Parker and Sophia McMillion; sister-in-law Pamela Armstead; and many nieces She is also survived by her furry companion Shirley was preceded in death by her grandmother who raised her Laura Armstead; daughter Leona Meninger; siblings Wanda (Fred) Truman Rosalie Armstead and Kenny Armstead; and son-in-law James Flinner Jr She enjoyed holidays and special occasions Shirley was employed by the Charleston Police Department as the crossing guard at Chandler Elementary She dedicated more than thirty years at Charleston Department Store where she enjoyed helping customers find the perfect fit whether it was jeans She and Stan formed Cantley’s Tuxedos and Suits and travelled West Virginia selling suits to the funeral industry and other professionals. Shirley served the community as a Girl Scout leader and fundraising benefiting Muscular Dystrophy through the US Postal Auxiliary December 27 at 11 am at Humphrey’s Memorial United Methodist Church in Tornado officiated by Harold Richards and Jacob Henley Internment will be at Cunningham Memorial Park in St Handley Funeral Home in Danville is assisting the family with arrangements. Humphrey’s Memorial United Methodist Church Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors Electrical and Computer Engineering faculty Dr Kurtis Cantley recently visited Hiroshima University along with representatives from major industry players such as Micron This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page announced the opening of a new location in Louisville The new offices are located in the Schnitzelberg Neighborhood at 1041 Goss Avenue The official ribbon cutting will be held September 28 of which BCCN is listed as a Title Sponsor Local Real Estate Agent Gant Hill discovered the new offices in a building that was the former location of Russman & Son Funeral Home The BCCN team worked closely with Kersey and Kersey Architects and A.L and Barry Wooley Designs on the modern interior "We couldn’t be happier with our new location and the BCCN building itself.” says Partner John A and I loved being in the middle of all the action but we decided with a couple of years to go in our lease that we wanted to own We looked for a long time at properties in a lot of different areas – Downtown Portland and more – and finally found a great fit in Germantown We are really looking forward to being a part of the Germantown and Schnitzelburg neighborhoods for the long term." says Will Nefzger "Taking on some of the most complex personal injury matters means we get to have a direct role in helping victims and their families move forward after being stricken by tragedy Staying 100% devoted to personal injury law matters means we get to make a real difference one case and one client at a time." Nefzger said Having a new spacious new location will allow the team to focus on the same high level of service to their clients One of the firm's major practice areas is personal injury law. BCCN is practiced in handling many types of injury cases including car accidents, wrongful death, product liability, dog bites/animal attacks Bahe Cook Cantley & Nefzger PLC has been serving the residents of the Louisville area since 2004. Five Partners and 11 knowledgeable, trusted lawyers are ready and able to help the area's residents with personal law practice areas. If legal help is needed, visit the firm's website at http://www.kentuckyinjurylaw.com Media Contact: Ashley Shadburne http://www.hatfieldmedia.com [email protected] SOURCE Bahe Cook Cantley & Nefzger PLC https://kentuckyinjurylaw.com Do not sell or share my personal information: Join the conversation You can save this article by registering for free here. Or sign-in if you have an account A 36-year-old woman from Lanark Highlands and a 38-year-old man from Cantley have been arrested and charged after Ontario Provincial Police found vehicles and other large equipment worth a total of more than $150,000 on Tuesday A news release from the OPP said officers were still reviewing all the items found during a search of a residence on McDonalds Corners Road in Lanark Highlands but the preliminary list included three vehicles A photo distributed with the news release also showed several hand-held drills a chainsaw and other smaller equipment pieces The OPP said Wednesday that the woman had turned herself in at its Lanark detachment on Tuesday evening. She was charged with seven counts of possession of property obtained by crime and then released from custody, scheduled to appear in court in Perth on Sept. 9. The man from Cantley was arrested at the location in Lanark Highlands and was charged with seven counts of possession of property obtained by crime, as well as failure to comply with an undertaking. He remained in custody and was scheduled to appear in court in Perth on Friday. The police news release said the search had been conducted by Lanark OPP, the East Region Community Street Crime Unit and the OPP Emergency Response Team. Lanark Highlands is about 80 kilometres southwest of Ottawa. The investigation was continuing, police added. The Sûreté du Québec is investigating the suspected homicide of a 28-year-old man who had been found seriously wounded in a Cantley home on Friday night. Subscribe now to read the latest news in your city and across Canada. Create an account or sign in to continue with your reading experience. At around 11:15 p.m., police from the MRC des Collines-de-l’Outaouais were called to a residence on Montée des Érables, where they found a man, identified by the SQ as Karapet Nikaelwan. The man was taken to hospital, where he was pronounced dead a short time later, a Sûreté du Québec spokesperson in Montreal said. The spokesperson said early indications “confirm” the man was the victim of homicide. However, authorities offered no further description of the injuries or other details. The SQ in leading the investigation with support from MRC des Collines-de-l’Outaouais. Cantley is about 20 kilometres north of Ottawa. This website requires JavaScript to function properly. Please enable JavaScript in your web browser. Lewis Cantley, PhD, director of the Cancer Center at Beth Israel Deaconess Medical Center and the William Bosworth Castle Professor of Systems Biology at Harvard Medical School, is a world-renowned scientist who studies the mechanisms by which cells respond to growth signals. Among his discoveries is the central role of the PI3K gene family in the proliferation of cells. PI3K is commonly activated in cancer and is now the target of new drugs being developed at many pharmaceutical and biotechnology companies. Known for his visionary insights and collaborative style, Dr. Cantley leads one of the five scientific “dream teams” awarded grants from Stand Up To Cancer (SU2C), the entertainment industry’s charitable initiative to accelerate development of groundbreaking cancer treatments. Support Mass General today to deliver quality medical care in our community and the world. Mass General Development Office 125 Nashua Street Massachusetts General Hospital is a non-profit 501(c)(3) organization, and donations are tax deductible to the full extent allowed by law. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply © 2025 Massachusetts General Hospital By Trudy Haywood Saunders When the Birmingham, Alabama, kitchen designer Cyndy Cantley, of Cantley and Company began her career thirty-five or so years ago she faced a lot of pickled cabinets and pink countertops—but not a lot of income “No one mentioned that with a degree in interior design you don’t make enough money to live,” Cantley recalls applying to a kitchen store that needed a designer This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. The couple never envisioned starting their own business, though, until Cantley was asked to design the kitchen of Birmingham’s Decorator Showhouse in 1992. “We had nothing to lose,” Cantley says. “Keith built the cabinets in his parents’ basement. People saw our kitchen in the showhouse, and the rest is history.” Since then, Cantley’s clients have run the gamut from newlyweds to the James Beard Award–winning chef Frank Stitt. Keith hand-builds all of the kitchen cabinetry and accents—doors, moldings, dovetailed drawers, and the like—in their Adamsville, Alabama, shop. “Southern kitchens need to be unique because we socialize in them as much as any room in our house,” Cantley says of that care and attention. “We always say the good, the bad, and the ugly happen around our kitchen table. To break bread with family and friends is what really matters in life, and I am humbled that I get to create these spaces for so many.” For those considering refreshing themselves, Cantley has a few tips. “You’re spending a tremendous amount of money. I know we cost more money, but in the long run, we can save you as much money as we cost just from [avoiding] mistakes. There are so many questions we ask clients about how they live. Hire the best people you can afford to hire and listen to them.” “I have clients say, ‘I feel like I should do brass hardware because it’s so in right now.’ I’m like, well, do you like brass hardware? Have you always liked brass hardware? You don’t have to do anything because it’s ‘in.’ Do what you’ve always loved and stick with it.” View this post on Instagram A post shared by Cantley and Company (@cantleyandcompany) “As much as I get excited when people do color on their cabinets now, I’ve truly made my living doing white kitchens with white marble countertops. If you love purple today, then let’s paint your walls purple or do some purple stripe in your window treatment, but don’t paint your cabinets purple.” View this post on Instagram A post shared by Cantley and Company (@cantleyandcompany) “I think Southerners need a lot of storage for all that china and silver we collect and inherit But don’t do all drawers because everything won’t fit in one I learned that years ago in my own kitchen when I had to put the vegetable oil under my sink because it would not fit in a drawer anywhere.” because you can put a lot of things in tray dividers You’re not digging down to get to the bottom Pyrex dish Always do two cutlery dividers—one for your everyday silver “I can’t imagine cooking without my spice drawer I have [my spices] in alphabetical order—and I’m really not that type of person you don’t have four basils because you know your basil is right there in the b’s.” we’ll do pull-out drawers [for food and water bowls] but we have to talk to people about how their dog eats are very nice to stick out in the laundry or kitchen We just had marble dog bowls made out of leftover black soapstone scraps The entertaining and home goods shop brims with elegant finishing touches and surcees The celeb design duo inspires with stunning Tennessee digs (that welcome visitors!) in a new book spring’s most beloved appetizer gets the stylish platter it deserves The future of conservation in the South just got a little bit brighter—and not just for salamanders but they’re the craftsmanship of local crustaceans called lawn lobsters The drawls are receiving a lot of flak across the internet but a North Carolina linguist argues they’re actually pretty accurate Lewis Cantley received his Ph.D. from Cornell University and did his post-doctoral work at Harvard University. He was formerly a professor in the Departments of Systems Biology and Medicine at Harvard Medical School in Boston. He is current the Meyer Director and Professor of Cancer Biology at the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine in New York City. Jihye Yun received her Ph.D School of Medicine under the mentorship of Bert Vogelstein and did her post-doctoral work with Lewis Cantley at Weill Cornell Medicine She is currently an Assistant Professor and a CPRIT scholar at Baylor College of Medicine in Houston. isolated and identified a 6-carbon carbohydrate a reference to its anti-scorbutic properties and later went on to receive the Nobel Prize in Physiology and Medicine in 1937 for his discoveries. Today vitamin C is a popular dietary supplement, and due to improved accessibility to fruits, vegetables and vitamin supplements, disability and death from scurvy are rare. However, it is worth noting that a significant number of people even in developed countries are still vitamin C deficient. For example, approximately 7% of the US population has a plasma vitamin C concentration of less than 11 μM, that is considered scurvy Vitamin C has many essential functions in our body in addition to its well-known role as an antioxidant prolonged periods of sub-optimal vitamin C exposure could have adverse health effects including an increased susceptibility to a plethora of diseases the optimal dosage of vitamin C required to maximize its health benefits has been hotly debated ever since its discovery a century ago a world-renowned chemist and two-time Nobel Prize Laureate strongly advocated that megadose quantities of vitamin C (above 1 g intake per day) would prevent and treat many illnesses including the common cold and heart diseases mainstream medicine has largely ignored or even ridiculed Pauling’s claim This controversy is still very much alive today Here we will highlight one of the mechanisms discovered by our group that relates to Ras protein. the biochemist Otto Warburg observed that cancer cells consume more glucose and produce more lactate even in the presence of ample oxygen as compared with normal cells called aerobic glycolysis or the Warburg effect has been exploited for visualizing tumors in the clinical setting by imaging their uptake of the radiolabeled glucose analog Although the exact mechanism by which glucose reprograming contributes to tumorigenesis remains unclear numerous genetic and pharmacological studies showed that this metabolic switch can be essential for cancer survival and proliferation targeting glycolysis may offer cancer patients a more selective strategy to treat cancer. Vitamin C as a cancer therapy has had a controversial past What has been intriguing are small clinical trials that suggest some responses but with no clear rationale for why cancers should respond to vitamin C or a path forward for explaining which patients are most likely to respond Now a growing number of preclinical studies are showing how high-dose vitamin C might benefit cancer patients these preclinical studies provide a clear rationale and potential biomarkers that may help personalize the therapeutic approach and identify patient populations that are likely to respond to high-dose vitamin C therapy Since the mechanisms of action of vitamin C are becoming better defined we can propose vitamin C combinations in a more rational given the current high financial cost of new cancer drugs it seems rational to improve the effectiveness of current therapies by studying their clinical interactions with vitamin C the implementation of this treatment paradigm could provide benefit to many cancer patients This work was supported by the US National Institutes of Health (NIH) grant (R35 CA197588) Stand Up to Cancer–American Association for Cancer Research grant (SU2C-AACR-DT22-17) and the Damon Runyon Cancer Research Foundation Lewis Cantley is a founder and member of the senior advisory boards of Agios Pharmaceuticals and Petra Pharmaceuticals which are developing novel therapies for cancer The Cantley laboratory also receives financial support from Petra Pharmaceuticals If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Intravenous High-Dose Vitamin C in Cancer Therapy was originally published by the National Cancer Institute.” Police from the MRC des Collines-de-l’Outaouais issued Thursday a request for public assistance in locating a 59-year-old Cantley resident. The van of Robert Vachon was found Monday in the Wakefield sector of La Pêche municipality, police said in a media release. “So far in the investigation, nothing suggests that Mr. Vachon would have been the victim of a crime, however the investigators fear for the safety of the subject,” the release said. Items collected in recent days led to a search of the Gatineau River near the Wakefield covered bridge with the help of Sûreté du Québec divers, but without success, police added. Anyone with information about the whereabouts of Robert Vachon were asked to contact Sgt.-Det. Sylvain Gauthier at 819-459-2422, ext. 4156 Cancer and diabetes may seem like two very different diseases, but they have at least one thing in common: both are driven by the misregulation of phosphoinositide 3-kinase (PI3K) a key enzyme in the body that promotes cell growth and division PI3K was discovered in 1985 by Lewis Cantley, Ph.D. Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College in New York City his research has shown that the activation of this enzyme causes major changes in cellular metabolism that can rev up the growth of cancer cells His groundbreaking work has been used to create drugs that act as PI3K inhibitors, leading to treatments not only for cancer but also, potentially, localized overgrowth syndromes are frequently caused by activating mutations in the PI3K enzyme And as this year’s winner of the Dr. Paul Janssen Award for Biomedical Research he’s committed to seeing even more therapies come to fruition Johnson & Johnson created the award in 2004 to honor Paul Janssen, Ph.D. the innovative founder of what is now called the Janssen Pharmaceutical Companies of Johnson & Johnson One of his landmark discoveries was that a patient’s diet may affect how effectively cancer treatment may work we noticed in our research that some cancer patients on PI3K inhibitors developed excessively high levels of blood sugar as a side effect,” he recalls which reactivated the PI3K in their tumor and caused their cancer cells to grow uncontrollably.” But a study conducted by Dr Cantley and published in the journal Nature found that going on a very low-carbohydrate appears to keep blood glucose levels and insulin levels down—and allows the drugs to work His lab is now researching whether combining an FDA-approved PI3K inhibitor with a ketogenic diet might improve outcomes for certain cancer patients Cantley’s work has led to the discovery of drug molecules like this one Every day we gain more knowledge about potential therapies that might be able to harness PI3K’s power to help treat disease.” who was honored in 2018 for his discovery of a new way to recruit the immune system to attack solid tumor cancers Cantley will receive a $200,000 cash prize to further his work as well as a sculpture with an inspirational inscription of “What’s New?” It’s a nod to the question Dr asked daily in his lab to encourage his colleagues to seek new ways to help patients and inspire the next big health breakthroughs “It’s a tremendous honor—all of the previous awardees are scientists that I’ve admired my entire life,” Dr “It still amazes me that a surprise discovery I made 35 years ago still drives potentially lifesaving drug research You should view the News section and the most recent SEC Filings in the Investor section in order to receive the most current information made available by Johnson & Johnson Services, Inc. Contact us with any questions or search this site for more information © 2025 Johnson & Johnson Services, Inc. Police in the MRC des Collines have taken a 34-year-old Gatineau man into custody after a two-hour standoff at a Cantley home Wednesday morning. Police were called to the home at about 8 a.m. following a disturbance. The individual refused to leave and officers set up a perimeter, blocking a number of surrounding streets in the small community on the east side of the Gatineau River. The man surrendered peacefully at about 10 a.m. There were no injuries. The investigation continues. This website uses cookies to personalize your content (including ads), and allows us to analyze our traffic. Read more about cookies here. By continuing to use our site, you agree to our Terms of Use and Privacy Policy especially to those in the science and research community One of his most notable contributions to science is the discovery of key pathways in cancer and diabetes that have led to the identification of novel treatments targeting defects in the identified pathways Cantley obtained a degree in Chemistry from the Wesleyan College and a PhD in Biophysical chemistry from Cornell University in 1975 He proceeded to Harvard University for his postdoctoral research which complimented in an Assistant Professor in Biochemistry and Molecular Biology position in 1978 He proceeded to become a professor of Physiology at Tufts University and returned to Harvard University as a Professor of Cell Biology in 1992 he progressed to become the chief of the Signal Transduction division and was one of the founding members of the systems biology department he moved to Beth Israel Deaconess Cancer Centre where he was appointed director and subsequently to the faculty of Weill Cornell Medical college and New York-Presbyterian Hospital He is currently the Margaret and Herman Sokol Professor and the director of the Sandra and Edward Meyer Cancer Centre a family of enzymes (proteins) which play roles in cell functions such as cell growth and proliferation This signal transduction enzyme can alter (by phosphorylation) a component of phosphatidylinositol ring consists of PIK3CA (an oncogene – a gene which when mutated (from its proto-oncogene form) can induce cancer and PTEN (a tumor suppressor gene – a gene which protects a cell from becoming cancerous) Both genes are linked to diabetes and cancer (via IGF1 and insulin) The Canada Gairdner International Awards are given annually to five biomedical scientists from around the world whose significant contributions to medicine have increased the understanding of human biology and disease More than 320 scientists have received Canada Gairdner International Awards since their inception in 1959 and of them 82 — or one in four — have gone on to win the Nobel Prize in Physiology or Medicine which carries a 100,000 Canadian dollar cash prize "The Canada Gairdner International Award is one of the most prestigious prizes in the world," said Dr who is also the Margaret and Herman Sokol Professor in Oncology Research and a professor of cancer biology in medicine at Weill Cornell "The fact that my peers had selected me to receive this award is a great honor." Cantley is being recognized for his groundbreaking discovery of an enzyme called phosphoinositide 3-kinase (PI3K) and the signaling pathway that it controls Cantley found that human cancers frequently occur due to activation of PI3K a breakthrough that has led to the development of drugs that target that signaling pathway — the first of which was approved by the U.S Cantley predicts that many more PI3K drugs will be approved in the future "We believe this will be a game-changer in the war against cancer," said Dr who received his doctorate from Cornell University "and will make a big impact on patient care." the Gairdner Foundation bestows the Canada Gairdner Global Health Award and the Canada Gairdner Wightman Award seven scientists were chosen by their peers for the 2015 Canada Gairdner Awards Canada's only globally known international science accolade Back to News We need to do everything we can to redress the imbalance between patients in hospital and healthcare professionals My Mum always told me to be wary of doctors a statement she had good cause to make in light of some of the care my disabled brother received I’ve found myself thinking back to a specific time my brother was admitted to hospital as a teenager That experience shaped how I viewed hospitals and continues to influence me as a doctor today I think it’s worth us all remembering how strange and scary hospitals are for those who have a disabled child My brother Iain had Duchenne muscular dystrophy it’s a pretty ghastly set of cards to draw most affected boys never get beyond a limited ability to walk followed by slow wasting over several years until they cannot manage even the simplest of daily tasks one of the coping strategies is to develop your own routine The problem with hospitals is that they too work to a routine And it’s unlikely that the pattern of yours and theirs is going to match I remember clearly that Iain needed help to be turned approximately every hour overnight one or other of my parents would shuffle through and then return to bed before being called again around an hour later and the staff in hospitals can be very scary It can be hard to question what is happening we were concerned to find the ward house officer returning repeatedly for more blood samples with all four of Iain’s limbs being contracted and misshapen Venepuncture was challenging for both doctor and patient and on the last occasion was undertaken by the appropriately named “femoral stab.” My parents simply scooped him up into his wheelchair and brought him back to the house It took him a while to recover but he did over time Iain later died in his sleep at the age of 21 part way through an Open University science degree He had several more fulfilling years and he certainly got something out of seeing me through to qualification as a doctor He had a clear view that he would never be admitted to hospital again I sometimes wonder whether the story would play out the same way today—there is much talk of being “patient centred” and holistic so perhaps the difficulties we experienced back in the 1980s would not be a problem now Although when I’ve spoken with friends who are disabled it seems that the mismatch between patients’ and healthcare professionals’ routines in hospital can still be a problem my experience as Iain’s sister made me more determined than ever to work as a hospital doctor I had a sense that I could change the world I couldn’t help feeling that there had to be a better way to do this—that we might work in partnership with patients and their relatives Whether it’s for patients or their families I have tried to interpret for them the mysteries of their illnesses and the treatments we offer I feel passionately that we need to provide written information for people—it’s hard to take in new information when you are scared and vulnerable I’ve been scribbling notes for people and drawing them pictures We need to do everything we can to redress the imbalance Many of our patients may be feeling scared or even frightened witless when I’ve never forgotten the importance of a good apology saying sorry is important to break down the barriers of lost faith in the system I’ve always disliked the phrase “discharged against medical advice.” If someone wants to leave the hospital My Mum is less wary of doctors than she used to be Patricia Cantley works as a consultant physician in the Midlothian Hospital at Home Team, offering an alternative to hospital admission for frail and older patients. She also works in the Royal Infirmary in Edinburgh and in the Community Hospital in Midlothian. She tweets under her married name of Elliott as Trisha_the_doc BMJ Opinion provides comment and opinion written by The BMJ's international community of readers and appeal to our international readership of doctors and other health professionals The best pieces make a single topical point For more information on how to submit, please see our instructions for authors. 2023 at the Hubbard Hospice House surrounded by family while fighting a courageous battle of intestinal cancer He is survived by his parents Carlos and Linda Cantley of Foster WV; older brother Kevin Cantley and wife Silvia Cantley of Chester VA and younger brother Jeff Cantley and wife Angel Cantley of Camp Creek Tracy was a talented musician and songwriter who enjoyed playing music with his buddies in the “studio” he created. Although Tracy had no children he was a big kid that enjoyed kidding around with his nephew and neighborhood kids WV with Mark Parsons officiating. Burial will follow in Danville Memorial Park on Indian Grave Road In lieu of flowers donations can be made to Hubbard Hospice House 1001 Curtis Price Way Archive Exhibitions Maryse Beaulne’s parents sat on the porch of their tidy brown brick bungalow in Cantley talking quietly and in obvious distress as friends and family came and went with hanging flower baskets and a sign that says “Amour,” is just metres from the highway where their 17-year-old daughter was killed in a hit-and-run accident early Tuesday It’s close enough to hear the traffic clearly “Do you have children?” Maryse’s father said in brief interview in front of the house I don’t have to tell you” what it’s like for the family He couldn’t speak after that as his voice broke The couple’s names weren’t immediately available Maryse was on her way to catch a bus at about 6:30 a.m on her way to school at le CEGEP de l’Outaouais but on Wednesday a man turned himself in to the MRC des Collines police twisting highway that demands a driver’s full attention when conditions are good when Maryse was hit were bad: “pitch black,” Const She was crossing Highway 307 near Cardinal Street when she was “clipped” by a northbound pickup truck The impact threw her into the oncoming lane she was struggling to her feet when she was struck by a second vehicle heading south The second vehicle might have stopped briefly before speeding away off There’s some indication the young woman might have been listening to music on an iPod or smartphone Off-duty police officers from MRC des Collines and Gatineau were nearby and were among the first on the scene Maryse was transported first to Gatineau Hospital then transferred to the Children’s Hospital of Eastern Ontario Though there is a street light near the intersection of Highway 307 and rue Cardinal “The driver saw that he hit something or somebody and pulled over right away,” Fournel said He turned on the orange flashing light on the roof of his company truck to warn approaching vehicles that there was something on the road “Last year we were in the same art class and I can’t believe you won’t be able to do more beautiful projects You made such beautiful things with your hands You were so gifted at creating masterpieces,” wrote Rosiane Mathé Rivard Friends also said she was always looking happy especially your beautiful smile,” wrote Kenny Duquette “Always smiling,” wrote Johnny Charlebois-Ethier A man died in Gatineau Hospital after a series of events where nurses didn’t check his vital signs staff didn’t share information with each other and nobody told the personal attendant watching him what a heart attack looks like Coroner Pascale Boulay said the death was “avoidable” and called for the provincial colleges representing doctors and nurses to examine the level of professionalism of the hospital’s staff in dealing with Marc-André Maxwell had fallen in his home in Cantley and cut his head He was an alcoholic and had been drinking before the fall At first he appeared to be recovering in the intensive care unit of Gatineau Hospital But the coroner and police uncovered a series of events in which his condition gradually worsened Maxwell was going through alcohol withdrawal but had to be strapped into the bed because he wanted to leave the hospital Maxwell was transferred to an ordinary room on Boxing Day At that point he was alert and his oxygen levels were good While he had been attached to electronic monitors at all times in intensive care this was no longer seen as necessary on the new ward He had never had heart trouble and wasn’t seen as a heart attack risk he was found pale and without any heart activity after a heart attack The coroner says there was “a fundamental gap in the sharing of information” among staff (for instance when information from intensive care didn’t reach his new ward) as well as the appearance that the staff worked in “silos” — separate groups that didn’t talk to each other Another problem: Maxwell’s condition was such that his vital signs should have been checked every four to six hours But no one checked them during the night he died even though his oxygen levels had started to drop According to the nursing staff it was part of their “internal culture” — passed on by veteran nurses to newcomers — not to check unless a doctor ordered it but the evening attendant went home before the overnight attendant arrived and “Again the appearance of working in silos without exchanging observations or information is significant,” the coroner wrote wasn’t familiar with the emergency procedures for reviving a patient And the attendant watching Maxwell didn’t know the signs of heart attack or respiratory depression that could be expected in someone withdrawing from alcohol Boulay recommended that the College of Physicians of Quebec examine the quality of medical care that Maxwell received beginning the day he left intensive care The report also calls on the Order of Nurses of Quebec examine the quality of care in this case by the nurses of 7 North And it calls for followup so that “young graduate nurses are provided with adequate supervision that allows them to exercise their clinical judgment without undue pressure.” The report also calls for standardized training for personal attendants so that they will know how to recognize the signs of a crisis The body that runs West Quebec hospitals (Centre intégré de santé et de services sociaux de l’Outaouais) says it conducted an internal inquiry after Maxwell’s death to see what it should do differently The measures include audits on a regular basis about the quality of care; better “communication tools” to ensure that information is shared by different units and different shifts; and better training in how to handle emergencies it wants to look for outside expertise to guide it in future a new perspective to make sure that we apply best practices.“ “Our organization has been deeply shaken by this situation and our thoughts go out to the Maxwell family,” it said tspears@postmedia.com Dr. Lewis Cantley, the Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center, has been awarded a grant from the Gray Foundation to study the genetic mutations that can lead to breast and ovarian cancer investigating how early-stage precancerous cells can be recognized by the immune system and targeted with preventive or therapeutic cancer vaccines Mutations in the BRCA-1 and BRCA-2 gene can result in significantly higher risk of breast and ovarian cancer in women The Gray Foundation focuses on BRCA-related cancers by accelerating research improving treatment and raising awareness for individuals who have inherited BRCA mutations Cantley’s team is one of seven multi-institutional multi-disciplinary teams to be awarded the grant and will receive up to $5 million for his research project entitled “Identification and Targeting of Post-Translationally Modified Neoantigens Presented in BRCA Mutant Tumors.” The BRCA proteins play a critical role in repairing damage to DNA Patients who carry inherited mutations in the BRCA genes accumulate DNA damage in their cells as a result of the lack of normally functioning BRCA proteins This DNA damage in turn leads to a cellular stress response that causes certain proteins in the cell to be altered compared to those in healthy cells scientists discovered that BRCA cancer cells can expose fragments of these atypical proteins to T lymphocytes in the immune system stimulating the T cells to fight the cancer Dr. Cantley’s lab proposes to identify these atypical proteins in early-stage lesions in women who have had breast reduction therapy and carry the BRCA mutation By detecting which protein fragments are frequently exposed on the surface of the precancerous cells investigators may be able to develop a vaccine that will enhance immune attack of early-stage lesions and thereby delay or prevent cancers in people with inherited BRCA mutations “We have the opportunity to advance an area of BRCA research that taps into the emerging power of cancer immunotherapies and cancer vaccines,” said Dr who is also a professor of cancer biology in medicine at Weill Cornell Medicine “We are incredibly grateful to the Gray Foundation for their support of this important research which has the potential to stave off cancer in women with these mutations.” “The progress being made in early detection and prevention of BRCA-related cancers is extraordinarily promising,” said Gray Foundation founders Mindy and Jon Gray “Our goal is to accelerate this work by supporting the leading researchers in the field.” Cantley is a founder and scientific advisory board member for Agios Pharmaceuticals and Petra Pharma Corporation These companies are developing novel therapies for cancer