This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Celkem 180 kilometrů dálnic a silnic prvních tříd se podařilo ministerstvu dopravy zprovoznit během čtyř let dosluhujícího vládního kabinetu Konkrétně začalo sloužit řidičům 96 kilometrů nových dálnic a 86 kilometrů silnic prvních tříd Práce na nových stavbách jsou v plném proudu aktuálně se staví dalších 123 kilometrů nových silnic Ministr dopravy Dan Ťok také začátkem příštího týdne zahájí dostavbu dálnice D6 nebo obchvat Slaného na silnici I/16 V roce 2018 budou postupně zahajovány další prioritní stavby Jednodušší a rychlejší příprava a výstavba dopravní infrastruktury zahájení výstavby dalších 180 kilometrů nebo lepší cestování na železnici Takové plány má vláda Andreje Babiše ve svém návrhu programového prohlášení který členové kabinetu schválili v pondělí 18 Rozjetá výstavba nových 230 kilometrů dálnic a silnic I převod nádraží do vlastnictví státu a zahájení oprav náprava špatně nastavené smlouvy na mýto a nový transparentní tendr To jsou základní výsledky Dana Ťoka za 1000 dnů ve funkci ministra dopravy Od roku 1993 se Ťok stává teprve třetím ze sedmnácti ministrů dopravy kteří v čele rezortu dopravy pracovali více než dva a tři čtvrtě roku V roce 2017 začne resort dopravy stavět dalších 140 km dálnic Ředitelství silnic a dálnic vypíše ještě do konce září výběrová řízení na zhotovitele u celkem 20 staveb za 64 miliard korun K provozování webu a analýze návštěvnosti používáme soubory cookies. Procházením webových stránek jste srozuměni s tím, jak se soubory cookies nakládáme. Kliknutím na odkaz zjistíte více o souborech cookies jak je používáme a jak je povolit či zakázat The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission Journal of Environmental Chemical EngineeringCitation Excerpt :Nanotechnology has produced creative approaches to water treatment [167] NPs produced from sugar beet and brick factory waste are inexpensive environmentally friendly amendments for metal-contaminated soil and water [148] The breakdown of plastic trash can utilise silica NPs as reported by Brewer et al Journal of Hazardous MaterialsCitation Excerpt :Previous studies described that the smaller particle size of adsorbents revealed a higher potential to be tuned as per requirement and the larger specific surface area endows additional active sites of the adsorbent thus improving higher adsorption efficiency (Puri et al. various nano-adsorbents including nano-HA have been produced for the removal of various contaminants including Cd(II) due to the high surface energy of nanoparticles the adsorption characteristics of nano-HA were greatly reduced owing to its easy self-aggregation properties (El-Nagar et al. All content on this site: Copyright © 2025 Elsevier B.V. Please enable JS and disable any ad blocker Metrics details The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long (p42) and short (p30) isoform Mutations within the CEBPA gene selectively deleting p42 are frequent in human acute myeloid leukemia Here we investigated the individual genomics and transcriptomics of p42 and p30 Both proteins bound to identical sites across the genome they induced a highly similar transcriptional response with the exception of a few isoform specific genes Amongst those we identified early growth response 1 (Egr1) and tribbles1 (Trib1) as key targets selectively induced by p42 that are also underrepresented in CEBPA-mutated AML Egr1 executed a program of myeloid differentiation and growth arrest Trib1 established a negative feedback loop through activation of Erk1/2 kinase thus placing differentiation under control of signaling differentiation elicited either by removal of an oncogenic input or by G-CSF did not peruse C/ebpα as mediator but rather directly affected the cell cycle core by upregulation of p21/p27 inhibitors This points to functions downstream of C/ebpα as intersection point where transforming and differentiation stimuli converge and this finding offers a new perspective for therapeutic intervention we investigated C/ebpα isotype-specific genomics and transcriptomics in primary hematopoietic precursor cells and its relation to HoxA9 mediated transformation Our findings suggest a particular role for p42 in establishing a signaling-dependent differentiation program The oncogenic activity of HoxA9 perturbs this program downstream of C/ebpα itself Our results emphasize the importance of a loss of-function for leukemogenesis and give potential perspectives how to bypass this defect for therapeutic purposes Transduction was done with CD117 (Kit) selected cells enriched with magnetic beads (Miltenyi Germany) essentially as recommended by the manufacturer cells were cultivated in methylcellulose (M3534 Germany) for two rounds under antibiotics selection then explanted and maintained in RPMI1640 (Thermo-Scientifc and 50 ng/ml recombinant murine SCF (Miltenyi All other chemicals were provided either by Sigma (Taufkirchen Antibodies were purchased either from Thermo Scientific (Darmstadt Germany) or from Cell Signaling Technologies (Leiden 0.5% N-lauroylsarcosine 1 mM PMSF and 1% HALT complete protease inhibitor cocktail) (Pierce Precipitation for all samples was performed with protein G coupled paramagnetic beads (Cell Signaling Technologies) Antibodies used for ChIP: anti-HA rabbit monoclonal Cell Signaling Technologies (#3724) 5 µl per 5 x 10e6 cells; anti-C/ebpα rabbit monoclonal Cell Signaling Technologies (#8178) 5 µl per 5 x 10e6 cells ChIP sequencing libraries were prepared using NEBNext® Ultra™ II DNA Library Prep Kit reagents (NEB MA) according to the procedure recommended by the manufacturer Size selection was done after final PCR amplification with Illumina index primers for 14 cycles Nascent RNA was converted into Illumina compatible libraries with NEBNext® Single Cell/Low Input RNA Library Prep reagents according to the standard protocol Sequencing was done at the in house core facility yielding 100 bp single- or paired-end reads Transcripts were quantified by Homer analyzeRNA routines and further analyzed with standard spreadsheet tools Where appropriate two-tailed T-test statistics were applied A Schematic depiction of wt Cebpa gene configuration and changes introduced to achieve isotype-specific expression A short upstream reading frame (uORF) controls use of ATG start codons within the main coding sequence leading to expression of long (p42) and short (p30) C/ebpα isoforms p30 retains only one of three transactivation domains present in p42 Replacement of the uORF by an optimized Kozak site allows isoform specific expression as shown in the western blot B Experimental set up of inducible C/ebpα expression in HSPCs Hematopoietic precursors isolated from animals with a knockout of neutrophilic proteases (Elane Ctsg triple ko) were immortalized either by HoxA9 or MLLENL and subsequently transduced in the presence of the degrader dTAG13 with p42-FKBP or p30-FKBP constructs Expression of the respective proteins was tested in the presence of dTAG13 and 24 h after release from degradation by western blot HoxA9 x p42-FKBP cells were cultivated for the indicated time in medium without dTAG13 and morphological aspect as well as expression of Myc and the differentiation sentinel gene Ngp (neutrophilic granule protein) were followed by May-Grünwald-Giemsa staining Micrographs were taken on a Zeiss Axioskop with a Nikon camera at 63x magnification The red arrowheads in the rightmost panel denote fully mature granulocytes characterized by an opening of the donut-shaped nucleus present in more immature precursors The figure shows one representative example out of three repeat experiments A Schematic overview of experimental setup B Integrated genome viewer visualization of p42 and p30 binding in the vicinity of Egr1 and Trib1 loci as examples for genes under preferential control of p42 (see below) The graph shows tracks for p42 and p30 as well as for endogenous C/ebpα binding in a total of two samples (cells pretransformed with either HoxA9 or MLLENL as labeled) C Global correlation plots of C/ebpα binding Occupation density of p42/p30/endogenous C/ebpα is plotted against each other at regions identified as p42 peaks in HoxA9 and MLLENL cells as indicated Given are values for CEBPA mutant and wt cases A Schematic overview of genomics experiment B Induction of Egr1-FKBP expression in HoxA9 pretransformed HSPCs induces growth arrest similar to p42 Shown is a representative example of a duplicate experiment C Example of a Egr1-specific ChIP and RNA-seq result as IGV tracks for select genes Cdkn1a and Id2 ChIP was done as duplicate and two timepoints for RNA analysis were sampled D Graphical representation of genes responsive to Egr1 Plotted are average expression values in the Egr1 off and on-states for those genes that showed a log2-fold difference between these conditions of at least 1.0 For representation expression values were averaged between duplicates E Gene set enrichment analysis of the Egr1-controlled expression pattern Please note that the Egr1-on state induces genes that are down-regulated by transformation with HoxA9/Meis1 (anti-correlation) Trib1 was either added to cells pretransformed with HoxA9 or it was used for direct transduction of primary HSPCs As Trib1 protein is highly unstable and cannot be detected by western blot qPCR was used to confirm successful Trib1 RNA expression as depicted in the bar diagram The lower panel shows a representative result (one out of three) of a replating assay demonstrating the transforming potential of Trib1 in comparison to HoxA9 Western blot experiments with extracts of HoxA9 (control) and precursors directly transformed with Trib1 (Trib1) cells The bar diagram depicts Myc RNA expression in the same cells (average and standard deviation of a technical triplicate) Immunoblots were developed with antibodies as indicated C Trib1 increases resistance against differentiation stimuli Cells co-expressing Trib1 and HoxA9 (or HoxA9-FKBP) as well as controls were subject to induced differentiation either by cultivation in G-CSF or by degrading HoxA9-FKBP through addition of dTAG13 for 48 h RNA was isolated at the indicated timepoints and expression of the differentiation sentinel gene Ngp was determined by qPCR A Morphological as well as genomic response of HoxA9/HoxA9-FKBP transformed cells to induced differentiation Cytospins were stained with May-Grünwald-Giemsa and photographed with a Zeiss Axioskop and a Nikon camera Shown are 63x magnifications and the scale bar corresponds to 10 µM Gene expression was determined for Myc and Ngp by qPCR The figure shows a representative example of a duplicate experiment B Western blot following endogenous protein expression in a time course during differentiation Blots were developed with antibodies as indicated C Intersection of Hox-mediated transformation with differentiation pathways at the level of the core cell cycle control machinery CDK6 is a direct downstream target of HoxA9 and also MLL fusion proteins and CyclinD1 (CCND1) transcription is strongly induced by activated Myc The schematic overview shows only part of the known interactions these studies compared steady state wild-type cells that contained both p42 and p30 to Cebpa mutants with p30 only Here we manipulate each isoform directly and individually although with the caveat that this always occurs on top of wt-expression these findings point to cell cycle regulators as unexpected major players that coordinate differentiation control by C/ebpα and transforming inputs through Hox-proteins to determine cellular fate Raw NGS reads were submitted to the European Nucleotide Archive under accession number PRJEB62028 C/EBPalpha deregulation as a paradigm for leukemogenesis C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors Wesolowski R, Kowenz-Leutz E, Zimmermann K, Dorr D, Hofstatter M, Slany RK, et al. Myeloid transformation by MLL-ENL depends strictly on C/EBP. Life Sci Alliance. 2021;4. https://doi.org/10.26508/lsa.202000709 A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity C/EBPalpha and the pathophysiology of acute myeloid leukemia The multifaceted functions of C/EBPalpha in normal and malignant haematopoiesis Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia Identification of gene targets of mutant C/EBPalpha reveals a critical role for MSI2 in CEBPA-mutated AML Gain-of-function effects of N-terminal CEBPA mutations in acute myeloid leukemia The dTAG system for immediate and target-specific protein degradation and proteinase 3 cause severe lung damage and emphysema Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins Leukemogenic MLL-ENL fusions induce alternative chromatin states to drive a functionally dichotomous group of target genes Fast and accurate short read alignment with Burrows-Wheeler transform Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities deepTools2: a next generation web server for deep-sequencing data analysis The Sequence Alignment/Map format and SAMtools Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes Delineation by molecular cytogenetics of 5q deletion breakpoints in myelodyplastic syndromes and acute myeloid leukemia Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis TRIB1 is regulated post-transcriptionally by proteasomal and non-proteasomal pathways STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1) Precise modulation of transcription factor levels identifies features underlying dosage sensitivity CEBPA-bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children’s Oncology Group CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation Requirement for CDK6 in MLL-rearranged acute myeloid leukemia Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle CDK6 as a key regulator of hematopoietic and leukemic stem cell activation A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis Download references We thank Renate Zimmermann for technical assistance This work was supported by research funding from Deutsche Krebshilfe grant 70114166 and in part by the Deutsche Forschungsgemeinschaft grant SL27/9-2 both awarded to RKS Open Access funding enabled and organized by Projekt DEAL Friedrich-Alexander-University Erlangen-Nürnberg and RKS performed and analyzed experiments All authors read and discussed the manuscript The authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41375-023-01989-8 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article A story is unfolding in Savannah involving several coincidences in history - long-term and short - uncovered by a disbelieving committee doing research at Savannah's Congregation Mickve Israel They're calling it the Slany-Savannah connection • The museum committee of Congregation Mickve Israel is working to showcase its 280-year past Co-chairs Phoebe Kerness and Herbert Victor are spearheading the research and put together much of the Slany information • A Torah collected during the Nazi occupation of Czechoslovakia is now on permanent loan and in weekly use at the Savannah synagogue The base of the Torah is inscribed with its provenance "This Scroll came from Slany and was written in 1890." It came to Savannah in 1968 She discovered via the internet that a B-17 bomber from the Eighth Air Force was shot down over the village of Slany At the airport in Slany is a monument and a plaque dedicated "In memory of the crew of the American bomber shot down at this spot on 2 March 1945" - two months before the end of World War II at Savannah Army Air Base-Hunter Field and generally credited with winning World War II in Europe.) • Former Savannahian Jeffrey Young moved 20 years ago to the Czech Republic but became intrigued with the growing connection of Savannah and Slany His father is Savannah attorney Arnold Young.) He took pictures and sent them home Most startling were the photos of the monument that had been on a mission to bomb oil fields in Bohlen He also translated the memorial's inscriptions Vivian Rogers-Price is research center director of the National Museum of the Mighty Eighth Air Force she directed a Mickve Israel museum subcommittee to original records about the mission He was in the tail section of the plane and fell to the ground before it crashed (Rogers-Price noted that the D-Day invasion would not have happened without the support of the Eighth Air Force until this day the European people are grateful to the Mighty Eighth.) • Mickve Israel Rabbi Robert Haas had planned a vacation this summer to the Czech Republic before the latest Slany-Savannah connection was uncovered said a prayer at the monument and toured the synagogue building the original home of Mickve Israel's Holocaust Torah It still retains on its façade a large marble tablet of the Ten Commandments and a Star of David the Torah is the centerpiece of its history on parchment (or deerskin in earlier times) it contains the first five books of the Bible week by week throughout the year - Genesis It's the Old Testament and forms the basis of Western religion At Mickve Israel it is read aloud in Hebrew The Slany Torah is one of 1564 Czech Memorial Torahs confiscated and saved in Prague during the Nazi occupation They have been distributed throughout the world as "permanent memorials to the martyrs from whose synagogues they come." A condition for custodianship of a Czech Torah is that it must be maintained in perfect condition used regularly in religious observance and for education and it must be returned if a synagogue is re-established in that town They were allowed to return in the early 19th century In 1890 the Jewish population in Slany was 290 the 81 remaining Jews were deported to Theresienstadt (Terezin) concentration camp In all the atrocities that the Nazis perpetrated during World War II on Jews and others they were determined to preserve some of the trappings of the people they were destroying and created a stockpile of Jewish ceremonial objects the Torahs were found stacked on wire shelving During the 1960s an effort was made by Jewish organizations to find homes for the sacred scrolls where they would be used and cherished and would bring meaning to the lives of the victims who had perished in death camps in Europe Savannah's Congregation Mickve Israel was one of hundreds of Jewish groups who accepted the responsibility to acquire a "holocaust" Torah on permanent loan one was brought over with the original Jewish settlers They are among the historic treasures of the congregation taken out once a year at the anniversary of the synagogue's founding and are believed to be the oldest documented Torahs in the United States now and probably forever will be known as the Slany Torah and the modern Hebrew script is more legible a Torah must be in perfect condition - no tears in the parchment It was on condition that the Czech Torah be properly maintained that it was sent to Mickve Israel the congregation will plan an appropriate welcome celebration Search for a publication Search for a meeting Export diversification has been among the most cited policy recommendations for African countries to spur structural transformation and increase resilience export diversification that benefits structural change is not an automated process and requires an analytical approach and complex decision-making Applying an adjusted economic complexity and product space methodology on trade data of 54 African countries and their trading partners this paper assesses export diversification opportunities that are feasible to realize associated with structural change and of high demand in the world and on the African continent Increasing complementarities of African exports and imports are crucial to yield higher benefits from the African Continental Free Trade Area (AfCFTA) The paper’s focus on intra-African diversification opportunities allows for a continental mapping of current exports with export diversification opportunities and the identification of niche areas of individual countries The paper finds that almost all countries have some potential for product diversification into light manufacturing (machinery and mechanical appliances; electrical machinery) and processed base metal products (articles of iron and steel) The paper’s findings can guide policymakers and development partners in identifying industrialization strategies and productive capacity needs interpretations and conclusions expressed in this document are those of the author(s) and do not necessarily reflect the views of the United Nations or its officials or Member States The designations employed and the presentation of material on any map in this work do not imply the expression of any opinion whatsoever on the part of the United Nations concerning the legal status of any country or concerning the delimitation of its frontiers and boundaries The Amorous Adventures of Bold Sir Hans Capon is the latest expansion for Warhorse’s hardcore medieval RPG Some spoilers for the opening of the Amorous Adventures of Bold Sir Hans Capon follow One of the standout characters in Kingdom Come is undoubtedly Hans Capon But over time he warms to you and reveals himself to be a charismatic thoroughly likeable character—something Warhorse was clearly aware of wine-loving heir to the Rattay throne the focus of its latest paid-for DLC expansion The Amorous Adventures of Bold Sir Hans Capon can be accessed after completing the quests Next to Godliness and Robber Baron Capon will tell you about a woman in Rattay he’s fallen for and asks for your help in wooing her—without her knowing and he wants me to help him win her heart secretly The first stage of which is recovering a family heirloom I travel to the tavern in Ledetchko where Capon lost the necklace but the local dice champion tells me he already lost the heirloom to a fancy-looking chap who was last seen at a river crossing near the town of Sasau I travel to Sasau and comb the river for clues until I find the nobleman in question—murdered and The savage nature of the killing leads me to believe bandits were responsible I'm wearing a raggedy shirt and battered armour As I’m investigating the crime scene a well-spoken man calling himself Sir Anselm of Domky emerges from the woods and tells me the nobleman was killed by bandits I instinctively reach for my sword and get ready for a bit of brigand slaying and infiltrate the camp to find out who the killer is—and maybe find that necklace I’m looking for in the process Making sure I know enough about Alphonse to deal with any questioning in the bandit camp Apparently he’s a keen dice player (no surprises there) from Slany and once worked for Prokop of Luxembourg hoping they’ll save my skin later on But there’s one problem: I look like shit I’m wearing a raggedy shirt and a ramshackle collection of battered armour I visit my house in Rattay and access my stash where I have heaps of clothes and other junk I’ve pilfered and purchased over the course of the game I find a fashionable cap with a feather in it battle-scarred Henry looks like a prancing toff I also stop in at the bathhouse to clean myself up and get a fresh new haircut and beard trim I head to the bandit camp and announce myself to the guard Keep up to date with the most important stories and the best deals Immediately I’m glad I quizzed Anselm about Alphonse saying I’m actually a native of Slany but tells me that the bandit leader—presumably Alphonse’s killer—is busy and that I should play some dice to pass the time As I explore the camp and eavesdrop on the foul-mouthed bandits I learn that the champion of a dice tournament wins a precious necklace: the very same one that once belonged to Capon before he foolishly lost it I throw 1000 groschen into the pot and enter the tournament but I absolutely stink at Kingdom Come’s dice minigame and he tells me it’s a guy called Pechuna I corner him and congratulate him on his victory and consider buying the necklace off him or pickpocketing it while he sleeps Instead I ask him how he’ll be celebrating and he tells me he’s walking through the woods to Sasau to drink I follow Pechuna through the trees until we’re well away from the camp then I pull out my sword and run it through him so the ‘fight’ is over in seconds which will help the cocky lord begin his quest to win the heart of that lovely lady in Rattay A nice final detail: as I look through Pechuna’s possessions I notice that he’s carrying loaded dice Suddenly I don’t feel too bad about stabbing him in the back and leaving him to rot in the forest We’ll have a full review up on the site soon And next time you decide to try and swindle someone in a dice game make sure they don’t have a sword stuffed down their silky pantaloons Andy KellySocial Links NavigationIf it’s set in space Workers assemble frames for hospital beds at the Linet factory in Slany A Czech hospital bed maker with a full order book received one more order that was impossible to turn down The company was approached by Prime Minister Andrej Babis to deliver beds for a military field hospital for 500 COVID-19 patients Workers add the final touches to a hospital bed being assembled at the Linet factory in Slany A worker assembles a hospital bed at the Linet factory in Slany A worker assembles frames for hospital beds A worker assembles parts for hospital beds A view of hospital beds being assembled at the Linet factory in Slany Czech Republic (AP) — Some orders are impossible for manufacturers to turn down A Czech maker of hospital beds received one this month Hours before the Czech government announced that the armed forces would be building a field hospital for 500 COVID-19 patients at Prague’s exhibition ground Prime Minister Andrej Babis approached the Linet company with a request to deliver the hospital beds for the facility “It’s a very special situation for us,” Linet executive director Tomas Kolar told The Associated Press on Monday Hectic negotiations between the company and the government are expected to result in the signing of a deal shortly for a total of 1,620 hospital beds Kolar said such an order would normally take 12-18 months to fulfil “it would be one week between the prime minister’s call and the first delivery.” The local health system has been under pressure and hospitals are filling up with patients As the number of people currently with the virus surpassed 100,000 in the Czech Republic over 3,500 of them need hospitalization and almost 600 of those are in intensive care according to government figures released on Monday The number of new cases has tripled in the past two weeks from a seven-day rolling daily average of 23.81 per 100,000 people on Oct The Health Ministry predicted the system could reach its capacity around the end of October such an order would not be a problem for a firm that is expected to make 120,000 beds this year 10,000 more than in 2019 and is considered the top European producer of hospital beds But with the virus putting pressure on health systems across the globe Kolar said the only thing to do to meet the government’s request was to delay some other contracts “We have been negotiating that with our clients,” he said we are able to meet the Czech demand,” he said the United States and other European countries It expects revenues to reach some 325 million euros ($383 million) this year Czech hospitals have been working recently to increase the number of beds available for COVID-19 patients to some 10,000 The field hospital in Prague is meant to be used as a last resort Follow AP’s pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak Ministr dopravy Dan Ťok slavnostně zahájil práce na téměř 10 kilometrech dálnice D6 mezi Prahou a Karlovými Vary Stavby Nové Strašecí – Řevničov a Řevničov obchvat uleví od tranzitní dopravy přilehlým obcím a zrychlí cestu z Prahy do krajského města Vysoutěženy byly obě stavby za dvoutřetinovou cenu září odpoledne řidiči projeli poprvé dvanáctikilometrovým úsekem ústecké dálnice D8 mezi Bílinkou a Řehlovicemi bez omezení Od páté hodiny ranní byl úsek uzavřený kvůli cvičení integrovaného záchranného systému testům a kontrole bezpečnostních a provozních systémů tunelů a změně dopravního značení července večer ve 21:00 středoevropského letního času poprvé odstartovala nosná raketa Ariane 6 Evropské kosmické agentury (ESA) Na zajištění tohoto startu se významně podílely i české firmy díky ESA programu Ariane and Vega Development Za účasti ministra dopravy Martina Kupky proběhlo v Paříži vrcholné zasedání Rady Evropské kosmické agentury (ESA) na ministerské úrovni Delegáti z 31 států společně jednali o prioritách Evropské kosmické agentury pro nadcházející roky využívání kosmických technologií v průmyslu nebo o rozpočtu pro vědecké a technologické programy ESA “Reaping the Potential Benefits of the African Continental Free Trade Area for Inclusive Growth” The African Continental Free Trade Area (AfCFTA) has the potential to be a game changer for Africa’s trade and economic development prospects As trading commences at this decisive moment and socioeconomic setbacks that African countries have experienced due to the coronavirus disease pandemic The launch of the AfCFTA presents a unique opportunity to promote inclusive growth and accelerate the achievement of the post-pandemic recovery the 2030 Agenda for Sustainable Development and Agenda 2063 of the African Union The United Nations Conference on Trade and Development (UNCTAD)’s flagship Economic Development in Africa Report 2021 aims to equip African governments and development partners with knowledge on how the AfCFTA can be beneficial for inclusive growth and help realize Africa’s untapped export potential UNCTAD and the United Nations Office of the Special Adviser on Africa (OSAA) will host a webinar to present findings of the flagship report and discuss the challenges and policy implications of the potential role of the AfCFTA in fostering inclusive growth in Africa.  Join experts and policy makers and engage in an exciting dialogue on the challenges and impact of COVID-19 Register to join the event.  See the programme  Read the report For more information, please contact Mr. Liwaaddine Fliss on liwaaddine.fliss@un.org and Ms. Anja Slany on anja.slany@unctad.org   Krista Sylvester February 06, 2023 He’s a jokester known for his sense of humour and vitality—and did you know that Carl Booth once danced with Princess Elizabeth? Booth is a 99-year-old resident at Evanston Summit Retirement Residence and he will be turning a spry 100 in March, prompting those at the facility to ask the public to send birthday cards to help celebrate this centennial milestone. Victoria Slany works at the facility and says during the pandemic, they did the same thing for another resident when he turned 100. He received 651 cards so they wanted to do something similar for Booth, who is a beloved resident. “Carl is one of our very funny residents who has been with us for about two years now. Let me tell you, he's quite the jokester and he is loaded with personality. He’s a really great guy, quite incredible,” Slany says. A veteran, Booth joined the Army in 1943, taking his basic training in Edmonton and his advanced training in Calgary before serving at Aldershot in England, just outside of London. That’s where he not only met the future queen of England, but he also had the confidence to ask her to dance. “He claims that one night there was a dance at the base and Princess Elizabeth was in attendance. He was pestered by his buddies to go ask the Princess for a dance,” Slany says. “Carl who is not shy about that sort of thing, went up to her and asked her to dance. She accepted and that's how Carl got to dance with the future monarch.” Booth was also stationed in North Africa and Italy and is currently a member of the Army Navy & Airforce Club in Edmonton. He's also a massive Edmonton Oilers fan. The greetings have already started flowing in for Booth, and Slany is touched by all of the sweet words and attention the man is starting to receive. He’s even received a birthday card from as far as Amsterdam already. “It’s so incredibly heartwarming and really cool to see all of the people that want to make it happen,” Slany says. The goal is to receive at least 100 cards, which will be hung around the residence. On his actual March 7 birthday, there will be a full day of celebrations and surprises. “It’s so incredibly special to be able to see the reactions and to be able to share that moment with them. To be able to create a memory for them, it’s so special.” Slany says this special celebration wouldn’t be possible without the help of gracious citizens from all over the world. “I just want to say thank you so much for helping to make Carl’s 100th birthday so memorable,” Slany adds. Birthday cards can be dropped off or mailed by Feb. 15 to Evanston Summit: Add your commentLoginLogin or Subscribe to participate.Calgary Citizen Local news, events, food, people. A 2x weekly newsletter to make you feel more connected to Calgary. CZECH REPUBLIC: A member of the medical staff treats a patient suffering from COVID-19 at the Intensive Care Unit of the Slany Hospital in Slany GENEVA/ZURICH — The World Health Organization on Wednesday warned against any complacency in the coronavirus death rate saying with the increasing number of cases New cases are hitting 100,000 daily in Europe Nearly 20,000 infections were reported in Britain Switzerland and Russia were among nations with record case numbers While deaths globally have fallen to around 5,000 per day from April's peak exceeding 7,500 WHO Chief Scientist Soumya Swaminathan said caseloads were rising in intensive care units "Mortality increases always lag behind increasing cases by a couple of weeks," Swaminathan said during a WHO social media event "We shouldn't be complacent that death rates are coming down." More than 38 million people have been reported infected globally and 1.1 million have died Despite the global push for a COVID-19 vaccine with dozens in clinical trials and hopes for initial inoculations this year from Johnson & Johnson and AstraZeneca's U.S while manufacturing billions of doses of an eventual successful vaccine will be a colossal challenge demanding hard decisions about who gets inoculated first it's starting with health care workers and front-line workers you need to define which of them are at highest risk "A healthy young person might have to wait until 2022." The WHO has said letting infection spread in hopes of achieving "herd immunity" is unethical and would cause unnecessary deaths limited and targeted restrictions on movements – to control disease spread We should only talk about it in the context of a vaccine," Swaminathan said "You need to vaccinate at least 70% of people .. "Mortality increases always lag behind increasing cases by a couple of weeks We shouldn't be complacent that death rates are coming down." PARIS — French President Emmanuel Macron ordered a third of France's population be put under nightly curfew on Wednesday to tackle a surging s… Poll results are published every Monday in The Guam Daily Post Saturday’s Mad Collab Block Party in Hagåtña brought together more than 70 local businesses and artists in celebration with hundreds of attendees It was all about the wonders of Artificial Intelligence in the palm of your hand All of the latest features in Samsung's Galaxy AI were showcased at a GTA-sponsored event Thursday University of Guam students and alumni presented original research at the 19th annual International Conference on Business Economics & Information Technology (ICBEIT) hosted by the University of Guam School of Business and Public Administration in Mactan Newtown Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Railway services in Prague and Central Bohemia will cater especially to hikers and bikers this season Both bicycle and steam trains will operate along traditional as well as new routes and Prague Integrated Transport (PID) said at a press briefing held earlier this week The tourist season commences on the weekend of March 23-24 and continues until Oct Cyclists can utilize two bike-friendly buses one for trips around Brdy and the other for Bohemian Paradise cycle buses will run through Kokořínsko on three lines The fee for transporting one bike on cycle buses will be CZK 20 The Cyklohráček excursion train for families with children and cyclists will depart from Prague to Slaný for the 11th time this year A colorful locomotive will pull four specially modified cars with room for bikes The cycle train will visit 14 places in Central Bohemia this year with some dates featuring a route to Zlonice there will also be rides on Tuesdays and Thursdays with Cyklohráček traveling to destinations like Dobříš The Central Bohemian Region currently boasts 501 kilometers (311 miles) of cycle paths with another 120 kilometers (75 miles) in preparation The region is constructing a 10-kilometer cycle path from Kutná Hora to Kolín in addition to the traditional nostalgic trips to Posázaví steam trains will once again head to Dobříš and Rožmitál pod Třemšínem steam trains will traditionally depart from Praha-Vršovice station Over 6,000 people utilized steam trains in Prague and the Central Bohemia region last year the railways are investing in improving the technical condition of steam locomotives they repaired three historic cars that will carry passengers this year drought conditions can complicate historic trains' operation in the summer Steam trains often cannot run due to the risk of fires along the railway railways can substitute them with locomotives from the 1950s Your morning coffee deserves a great companion. Why not enjoy it with our daily newsletter? News from Czechia, curated insights, and inspiring stories in English. Germany is realigning its development policy partnerships around migration Hubertus Heil is delighted. Heil is Germany’s Federal Minister of Labour. He and Svenja Schulze, the Federal Minister for Economic Cooperation and Development children welcomed the two ministers with singing and dancing “It really makes your heart swell,” says Heil Karola Slany from Berlin set up this primary school 27 years ago Many of her protégés have since gone on to secondary education and even university but no-one has yet made it as far as Germany she says: “Germany is a long way off for our children.” The Federal Government agreed the key points in late November 2022 and the proposed amendments to the Skilled Immigration Act will be presented to the Bundestag in the near future We use YouTube to embed content that may collect data about your activity Please review the details and accept the service to see this content The intention is to ensure as far as possible that the movement of skilled workers to Germany does not worsen the situation in their countries of origin Heil and Schulze used their visit to Accra to send a positive message about migration “This is about the economies of both countries being able to benefit,” Heil says “That’s why it’s good to work together and create a win-win situation,” Schulze adds While in Accra, Schulze and Heil are setting a new strategic direction for the Ghanaian-German Migration Advice Centre The centre is located right next door to Ghana’s Ministry of Employment and will help those interested in moving to Germany and the EU find ways of getting there Ghanaians who want to emigrate will also be able to find out how to start by first trying a move to a different country in Africa The Centre will also continue its work supporting Ghanaians returning from Germany helping them to regain a foothold in their homeland Germany has promised support which includes help with setting up a business “If this gives the impression that we want to take bright and skilled professionals away from this country He notes that despite Ghana having a population of just under 34 million but there is a surplus of well educated people who cannot find a job Ghana’s population is predicted to grow by a further 7 million over the next 10 years “That’s why it’s important that we ensure in more ways than one that migration is fair.” Compared to some other countries in West Africa Many young people who attended Karola Slany’s school as children now work in Ghana as teachers Ghana still suffers from inflation running at over 50% and the economy is struggling On the issue of illegal movements of refugees Heil explains that “What we’re trying to do is prevent people from taking lethal journeys across the Sahara.” Under the Skilled Immigration Act people wanting to emigrate to Germany will be chosen according to their professional experience or links to Germany More centres like that in Accra are planned for Morocco © www.deutschland.de