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By continuing to browse this website, you give your informed consent to our Cookie Policy This symposium will bring together scientists focused on the physics of defects in 2D materials to discuss recent progress and challenges in the field including "state of the art" in theory and characterization techniques - Defects in 2D materials for quantum technologies - Characterization of defects in 2D materials - First-principles modeling of native defects and impurities in 2D materials - Production of defects in 2D materials under ion-irradiation - Electron-beam-mediated engineering of 2D materials through controllable introduction of defects Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Iowa as a great athlete and especially skilled baseball player he was also known as the hardworking and handsome Bobby-John - the loyal and hardworking local grocery store employee whose lady patrons just loved to have walk their groceries home for pleasant company.    He was an athlete that played baseball and basketball that received offers to play at schools including Arizona State University  Bob was awarded a Baseball scholarship and attended Upper Iowa University.He graduated with a double-major in Business and Physical Education  He played minor league baseball with the St Louis Cardinals organization before starting a career in education as a teacher in Des Moines IA  He then served in the United States Army National Guard scouted for the Cincinnati Reds organization and coached baseball while remaining a lifelong Reds fan  He coached baseball all through his life including for his sons and grandsons  There was never a sports store he could pass up checking on the new sports caps or memorabilia of baseball's greats  Graduated from Drake University of Des Moines with an MS Degree in School Administration  Bob was later employed by Ankeny Schools of Ankeny,Iowa  A kind man that loved to laugh with a great charisma and matching sense of humor that spanned from juvenile to witty in moments of orneriness and comedic collaboration with his sons  He had firm grasps on what was right and wrong and the value of "keeping your word" while teaching that to his children and grandchildren helpful and knowledgeable and he was a dedicated  He always found the time to help with baseball  He found joy in family get-togethers  His passion and love for chocolate was boundless having beaten cancer and living a life with chronic pain were married in 1970 and shared 51 years together  They celebrated their last anniversary this past June 2021 He is preceded in death by his parents Robert Bruce and Lucile Sierck Beilstein  Grandparents: Roy and Gertrude Flanagan Beilstein   Otto and Marie Sierck (maternal side) Uncle Jack (John) and Virginia Beilstein and their son Pete Beilstein He is also survived by Michael Roy Beilstein Graveside services will be held Saturday, May 28, 2022 at St. Mary’s Catholic Cemetery in Williamsburg.  Visitation will be Friday, May 27, 2022 at the Powell Funeral Home in Williamsburg, from 4:00 to 7:00 pm.  A memorial fund has been established for the Williamsburg High School Baseball Program.  Messages and tributes may be directed to www.powellfuneralhomes.com.   All text and images © Powell Funeral Homes Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors WV (LOOTPRESS) – According to the Milton Police Department a man has died after being shot by his son Thursday afternoon dayshift officers with the Milton Police Department were dispatched to Woodmire Drive for a shooting in progress call O’Dell arrived to find Mark Beilstein gravely wounded by gunshots Arrested at the scene without incident was Mark’s son The victim died at the scene and Jacob Beilstein was charged with first-degree murder and wanton endangerment relating to a young child that was in the home during the shooting Jacob Beilstein was arraigned before magistrate Kim Wolfe and ordered held without bond No other information has been released at this time Lootpress brings you the latest news in Southern West Virginia and around Please enter your username or email address to reset your password Create your free account to receive personalised content alerts and Re:action our weekly newsletter of the top chemical science stories handpicked from a range of magazines journals and websites alongside insight and analysis from our expert editorial team Tell us what you think. Take part in our reader survey By 2022-06-09T08:37:00+01:00 A digital database just isn’t as evocative as the smell of the stacks Source: © The History Collection/Alamy Stock Photo Organic chemist whose systematic notes ultimately led to the Reaxys database the word ‘stacks’ conjures twin sound and smellscapes associated with walking down the narrow canyons of library shelves For current journals you might flip through the table of contents to see the latest news But the search for older articles had a daunting learning curve involving several key gateways The indices of Chemical Abstracts occupied one end of the library’s collection of journals These gave you a list of cryptic code numbers like 89:463186k each of which referred you to a short abstract buried in countless volumes further along the shelves The abstract now pointed you to the original article which was hidden somewhere deeper in the stacks with their unmistakable smell of books If on the other hand you had a specific organic molecule in mind there was Beilstein a monumental index of almost every carbon-containing compound ever isolated I remember having to attend classes to learn how these systems worked I remember wondering who were the cataloguers and abstract writers who spent their lives indexing chemistry for us The most famous indexer was Friedrich Konrad Beilstein, a Russian-born German. After graduating with high marks from school in St Petersburg at age 14, his godfather paid for him to go to university in Germany where he studied under Robert Bunsen in Heidelberg. He then moved to Munich where he worked with Justus von Liebig and Philipp von Jolly where he worked on the structure of the dye/indicator murexide with Liebig’s great friend Friedrich Wöhler Beilstein got his doctorate at the age of 19 he finally returned to Göttingen as Wöhler’s assistant But the lack of organisation of the chemical literature bothered him He began to make systematic notes about organic compounds building up notebooks filled with formulas and reactions a process that would gradually turn into an obsession that some might think a little dull He was an excellent pianist who held musical evenings at home spoke four languages fluently and got by in two more witty and with a fast repartee; his letters are filled with amusing and sometimes quite sharp comment about his contemporaries He seldom revealed anything about his own life and feelings replying to questions by changing the subject or with misleading answers he was appointed professor of chemistry at the Technological Institute in St Petersburg succeeding Dmitri Mendeleev who moved across to teach on the inorganic side Mendeleev would publish his periodic system the following year Beilstein’s position came with a comfortable flat and solid funding He continued to work mostly on aromatic chemistry and developed his eponymous copper-based flame test for halocarbons He was also an editor of Zeitschrift für Chemie where he battled to get the publishers to produce formula and structural indices Beilstein was in many ways deeply conservative and mistrustful of the new structural theory As the isomers of each supposed chemical species multiplied Beilstein’s response was ever more cautious In a letter to his colleague Alexander Butlerov he quoted a French phrase ‘La chimie organique est la science des corps qui n’éxistent pas’ – organic chemistry is the study of things that don’t exist Given that knowledge of the invisible chemical world was inferred from earlier how could one know that any of it was real ‘Do these billions of compounds really exist Just think of the myriad variants of cetyl alcohol I just cannot believe that God wanted to make life so difficult for chemists.’ Meanwhile his listings of compounds were growing. He wanted to write a textbook of organic chemistry In 1880 he published his first handbook of organic compounds one of the first cheminformatic compilations which listed 15,000 compounds and attracted immediate attention – it was now possible for chemists to look up molecules by structure He immediately needed to produce a second volume Even on holiday he would spend hours trying to organise the mushrooming literature into usable listings the overwhelmed Beilstein agreed that the German Chemical Society would take over from him After his death in 1906 the fourth edition was published By the time I started using Beilstein the volumes were hugely useful but decades behind Today the entire enterprise has become digital and Beilstein lies at the core of our cheminformatic searches Millions of structures can be explored without stepping away from your desk I miss both the walk to the library and that smell Site powered by Webvision Cloud KVAL News: I’m joined by Pacific Green Party candidate for the Oregon’s 4th Congressional District Troubling news month after month with the national inflation report Sitting around and over 8% for several months That can take a toll on a lot of people in the 4th Congressional District What do you think should be done at the federal level to address this issue I think people fail to recognize the inflationary effects of military spending it’s probably over a trillion dollars in defense spending and defense spending is inherently inflationary inflation occurs because there’s money circulating in the economy that’s not matched by goods and services if anything it destroys utility rather than building it so it’s amazing that during the Vietnam War that was a clearly understood fact that military spending was causing inflation and yet now nobody talks about military spending as the cause of inflation and I think it’s one of the main ones don’t tend to address that issue and continue to support the rise in military spending It’s really not one ideology versus another Both tend to support more spending in the military MB: I’d say that the political parties that are in power they’re just different brands of the same product banks and real estate and insurance and the fossil fuel industry they pretty much control the policy of this country and whether you’re a Democrat or a Republican you’re not gonna go against those because if you do you’re not gonna get anywhere That’s the reason – most things that people in this country want – we want secure retirement we want healthcare that’s available to everyone we want a rational immigration policy but things are not done for the benefit of the people in this country They’re done for the benefit of those three centers of power: finance military spending or the arms industry and the fossil fuel industry And as the cost of living is going up wages aren’t keeping pace with that and that’s one of the issues that makes the rise of inflation so troubling for a lot of people the fact that wages just don’t seem to be rising at the same rate as inflation MB: It’d be great to have wages rising to match the level of inflation I think we’ve got a fairly good minimum wage in Oregon although I certainly think it’s not adequate but in general the minimum wage in the country – I think federal minimum wage is still around $7.00 an hour It’s less than half of what it was at its peak The failure to raise the federal minimum wage has been a real problem I think the main contributor to inflation in the country is actually housing costs and that’s why we’re seeing such a rise in homelessness is because as housing costs both ramp and housing prices have risen faster than the wages then people at the bottom end were struggling to stay in a home now find they can’t and so I think a substantial housing program that involves public housing I think would be a good solution to inflation and to the homeless problem Some of the places where they have the best housing in the world is almost all public housing In Vienna 70% of housing is either public or its cooperative-owned Unfortunately housing has become an investment opportunity in this country rather than a utility but people don’t buy a home on the basis that they’re gonna live there but they’re also thinking that this is gonna be an investment and I can sell it for a lot more in a short time than what it costs now and so this I think public housing is one way to counter that to have competition with the private markets so that public housing would be provided as a utility rather than investment opportunity and so I think to take housing out of the finance system I think would be a big help We’ve seen another wildfire season with more destruction poor air quality that we still have and a consistent fear for a lot of people in this district that every time it’s summer and late summer or early fall How do you think we can manage this crisis better we should definitely be putting more into management of forests and I think we need to be managing forests both to prevent fire damage but also as using forests as a carbon sink Really the way forestry has operated in Oregon it’s been like strip mining of our forests for the benefit of Wall Street interests and it’s really Oregon is being treated like a banana republic is not really getting the benefit of the forest industry here and I think that’s something that’s got to be changed We need to make sure that forestry is done for the interests of the state for the workers in the state and not for the benefit of outside investors and of course the fire danger – some of the biggest fire danger comes from actually tree plantations there’s natural fires that occur in the old-growth forests but the tree plantations are a bigger problem than the old-growth forests but regardless we need better management of our forests We need to be growing them for carbon storage and we need to be using fires judiciously to prevent these large gigantic fires from occurring because of the buildup of fuel Oregon is perhaps the most accessible state for abortions in the country which would essentially supersede Oregon laws Would you support any limits to Oregon’s current laws I certainly would not like to make women’s healthcare less accessible in Oregon than it is now I think federally I don’t think that there’s really much chance of passing a nationwide abortion ban I think it’s much more likely that if the Democrats can keep control of the House and the Senate through this next election that we're more likely to have an enshrining of Roe versus Wade protections in law which the Democrats could have done any time in the past and it has not happened yet but I see that as a more likely outcome and of course a more welcome outcome than any further restrictions on women’s healthcare as a third-party candidate I don’t have any fantasies about being elected I’m fairly certain that Val Hoyle is going to be elected but I’m satisfied with knowing that Val Hoyle’s going to be elected I might point out that I’ve run five times against Peter DeFazio and I never considered Peter DeFazio an enemy we were on the ballot together and I was running against him but I’ve always admired him as a very good progressive Democrat but unfortunately he wasn’t a Green and neither is Val Hoyle And one of the things I know you want to push for and at least use this podium for is the way Congress is handling right now war and the situation going on in Ukraine I think if the United States had just stayed out of it Russia and the Ukraine had negotiated a peace as early as April of this year and the United States and Britain stepped in and said We have to keep fighting.’ And so it’s basically a proxy war which the United States and NATO is fighting a war with Russia but we’re using Ukrainians to – we’re killing Ukrainians instead of our own soldiers but it’s a very dangerous thing to be doing I think Russia has some legitimate aims in the region and certainly Ukraine joining NATO was something that would have been very threatening to Russia and so I think certainly this war was provoked by the United States and NATO I’m not saying the invasion was not a war crime I think there’s always alternatives to war but I do believe the United States is very much responsible for the war and for continuing it and making it as devastating as it is It’s making it into a situation where Russia feels that their existence as a country depends on winning this war so I don’t see any hope of Russia deescalating It’s always going to end in negotiations so let’s start the negotiation now and let’s stop the carnage that’s going on in Ukraine Do you think the idea behind it was to weaken Russia without using our own soldiers or is it to keep it going for what you talked about before we’re bumping up our arms in order to support the Ukrainians There definitely is kind of a grand strategic plan that the United States wants to ensure that there’s no regional powers really that can confront the United States and so the powers that could confront the United States is of course China and Russia and so the United States has been very deliberately kind of encircling this expansion of NATO throughout essentially all of Western Europe and now Eastern Europe as part of that and the wars in the Middle East and Afghanistan and now the provocations in Taiwan and so there’s definitely this kind of encirclement that is occurring against Russia and China and so the war in Afghanistan is just kind of the result of that and at some point they might push too far in China over Taiwan or something as well So there’s definitely the financial aspect they’re all in favor of this because it means they’re a growing industry and you know returns for their investors are increasing but at the same time there is this grand strategy as well of encircling in geopolitics they call it the Eurasian landmass and so this constant threat against Russia China and Iran is ultimately with the idea of encircling and enforcing the will of the United States or the investors of the United States on those countries but it’s happening at the same time when the United States is becoming a weak economy and then with the great natural resources of petroleum especially in Russia unless the United States can break that alliance I think we’re headed to a place where there’s really no choice for the United States We’re gonna lose our empire or we’re gonna end the world in global war So I think people have got to start realizing that in the United States They have to start not automatically supporting greater U.S taking into account what you said about running as a third-party candidate but let’s say you were in Congress and that vote for more aid comes before you would you not support more aid being sent to Ukraine MB: I think if I was in Congress I would oppose any export of weapons outside the United States the United States is essentially providing almost half of the weapons that are exported for countries in the world We’re making it a more dangerous place by doing that and definitely I would be looking – in Congress I would be looking for cuts in the military budget I would say cuts of at least 50% are necessary whether it be Saudi Arabia or Israel or Ukraine He’s running for the Green Party for Oregon’s 4th Congressional District Watch our interviews with the other candidates for 4th Congressional District: (WCHS) — A Cabell County grand jury handed down several indictments this week Kristopher Jason Brown, of Huntington wanton endangerment and use or presenting a firearm during the commission of a felony Police said a restaurant employee was struck by a bullet during an altercation involving Brown that unfolded in November 2022 Gavin Scott Bailey, also of Huntington has been indicted on charges connected to the same shooting including murder and wanton endangerment Investigators said Bailey was the driver of the vehicle where the shots were fired Charges for Brown and Bailey were upgraded after the victim, identified as Joseph Bryan died from his injuries less than a week after the shooting took place Chris Ortiz-Velez, of Huntington Huntington police said gunfire outside of an apartment housing several children struck a youth in the hand Logan Burns, of Huntington has been indicted on charges of wanton endangerment burglary and use or presenting a firearm during the commission of a felony Officers said Logan is accused of shooting a man and striking several people with a gun in a Guyandotte neighborhood in August 2022 Daniel Francis Miles, a teacher at Barboursville Middle School has been indicted on charges of first-degree sexual abuse and sexual abuse by a custodian or person in position of trust to a child Court records documented instances of inappropriate language and conduct with students messaging students after instructional hours and looking into student restrooms Cabell County Schools reported Miles was placed on paid administrative leave due to alleged misconduct in January Eight candidates are running for four at-large seats on the West Des Moines School Board The Des Moines Register asked each candidate to respond to questions on why they're running and the issues their district is facing Their answers may be lightly edited for clarity or length EDUCATION: Bachelor of Science in pharmacy University of Iowa; Master of Business Administration POLITICAL EXPERIENCE: West Des Moines Community Schools Foundation spring 2022; 45 years of county political committee work in Iowa and Florida Advocacy work for American Association of Colleges of Pharmacy Chicago Kent College of Law; bachelor's in communications POLITICAL EXPERIENCE: No paid or elected political offices; Youth mentor and leader at Lutheran Church of Hope for past eight years Air Force Academy; Master of Public Administration POLITICAL EXPERIENCE: West Des Moines School Board curriculum and instruction: literacy education The University of Minnesota; Master of Arts in early childhood education University of Iowa; Bachelor of Arts elementary education September 2015-present; United Way Education Cabinet Iowa State University; Bachelor of Science in business management POLITICAL EXPERIENCE: I have spent hundreds of hours volunteering in West Des Moines schools including being a member of the School Improvement Advisory Committee and leading the parent groups at my children’s elementary and junior high schools EDUCATION: Master of Business Administration EDUCATION: Bachelor of Science in political science Simpson College; Bachelor of Science in elementary education POLITICAL EXPERIENCE: West Des Moines Parks and Recreation Commissioner 2019; West Des Moines Community School Board candidate EDUCATION: Bachelor of Science in business administration POLITICAL EXPERIENCE: No prior political experience More: Election Day in Iowa is approaching. Your guide on Des Moines metro candidates, issues Michael Andreski: I am running for the WDM school board because I believe in public education As a Valley High alumni and parent of a Valley alum I’ve seen the life-changing effects of the education that students receive in the WDM schools I was well prepared for the rigors of a health professional program and I will work to ensure that the high level of excellence in our schools continues Our schools are a wonderful reflection of the increasing diversity in the WDM school district and I want to support the work being done to make all students feel valued Laurie Beilstein: Restore WDM to an academic center of excellence for all students to develop the essential skills needed to navigate a changing 21st-century workforce and world economy Jeff Hicks: Serving on the school board has allowed me the opportunity to give back to my community in a way that aligns well with my background I believe a strong public education system has historically been the backbone of our country and this gives me a chance to play a small role in helping ensure all students have access to a high-quality education Jill Caton Johnson: I am an advocate for quality and accessible public education I have the professional skills to help WDMCS navigate these changing educational times a former WDMCS teacher and a parent of two Valley High School graduates I am invested in the success of West Des Moines Schools I look forward to supporting teachers and staff in raising academic achievement improving collaboration and trust across the district and creating positive and safe learning spaces for all kids Elizabeth Larson: I am running for School Board for the kids I will ensure that WDMCS’ public education provides opportunities to every student we serve We know that students learn best when they feel safe and know they belong We know that seeing themselves in the curriculum is one of the best ways to engage students in the learning materials We need to not only continue to identify areas where we are not meeting these needs and address them but proactively be seeking ways to improve the educational experience of every single child in our district Teri Patrick: I am running for West Des Moines School Board because I believe in investing in the next generation Every student possesses the capacity for greatness their achievements can surpass even their own expectations My commitment is to empower students for success I envision a West Des Moines district education that prioritizes academic excellence ensuring students are not only positioned for success but also inspired to reach their full potential I want to help students and families feel like they have a future We have been fighting the academic achievement gap for so long and having an experienced public school teacher and current parent of a West Des Moines Schools student can only be a positive to get every student closer to that brighter future they deserve Scott White: My primary responsibility to the district will be to restore traditional values and discipline to the curriculum and instruction for all our students Only students equipped with such knowledge developed in grades K-12 will go on to be engaged citizens in an increasingly multicultural world More: Who is running for Des Moines suburban city councils, mayor in the 2023 election Michael Andreski: The challenge of maintaining the traditional excellence of the educational experience for an increasingly diverse student population This is even more difficult due to the funding cuts from the state of Iowa due to the “Students First Act.” Funding will also impact the constant challenges to the ability of many of our students to be comfortable in the learning environment all expenses will need to be examined to determine the impact on the learning environment and focus resources on the spending that most enhances that environment Laurie Beilstein: Core academics: Post-secondary preparedness is 51% teacher and administrator task force to develop a classical liberal arts curriculum with defined success criteria Jeff Hicks: One pressing issue is overcoming the impact of the pandemic on our students’ academic progress and mental health COVID was especially impactful on our most vulnerable students Students need to feel welcomed and that they belong at school we must ensure our students’ basic social and emotional needs are being met we can’t expect our students to be in mindset receptive to learning we need a strong core academic instructional program that challenges our students and brings out the best in them Jill Caton Johnson: Academic achievement is the most pressing issue in WDMCS I will support curriculum administration to use data and specifically address areas of low achievement We also need to support students who are on the high side of achievement I will also advocate for resources and professional learning for teachers and associates so they can meet the needs of each of their students Elizabeth Larson: The most pressing issue facing WDMCS is the mental health crisis driven by significant increases in anxiety and depression With state funding lagging behind inflation schools are being forced to choose between addressing these mental health challenges and current programming we must create a safe and welcoming environment at school for our students We need to create a culture of inclusivity and seek expert assistance to meet the mental health needs in our district the district needs to be more intentional in pursuing outside funding to address mental health concerns in our district Teri Patrick: One of the most pressing concerns in our district is academic proficiency Looking at district proficiency rates in English/language arts and mathematics The district scores are 72.91% and 67.51% respectively with one elementary school scoring in the mid-50% proficiency the post-secondary readiness index composite score is 51.31% and find innovative strategies that enable us to meet students at their current level and provide the support to facilitate their meeting proficiency standards Aaron Sewell: Academics took a big hit when COVID took over Our students and schools are rebounding slowly but we need to remember there have been academic challenges before COVID Students need structured education that will challenge them and instill core skills to grow as learners They also need to feel safe and welcome in their environment Teachers need to feel supported across the district so that they can serve our kids to the best of their abilities Scott White: Accountability to and from all district stakeholders will be my top priority I will analyze each policy at the granular level My guiding principle will be to get the best outcomes for our students while always recognizing our fiscal responsibility to our taxpayers focusing particularly on the administrative level Michael Andreski: While it is appropriate to follow the law as much as possible the way that this law is written makes it impossible for both students and staff to comply with the law and to respect the autonomy of students and staff The requirement for and definition of “age appropriate” is vague except for banning descriptions or visual depictions of a sex act as defined in the Iowa Code The ban on providing any age-appropriate information on gender identification and sexual orientation flies in the face of the realities of the lives of many of the students and staff Laurie Beilstein: I support freedom of speech; censorship is wrong Common sense and reasonableness are needed when discussing this issue or it becomes a political football dividing us Jeff Hicks: As we enact policy designed to comply with SF 496 how can we minimize the harm this legislation has caused to some of our families and students by working with our families to understand where support is needed and to ensure that every student feels welcomed we design policies that are clear and can be operationally implemented in each building It’s important that we minimize the distraction and risk for our teachers and administrators so that they can remain focused on teaching and caring for our students Jill Caton Johnson: 1) Support teachers with changing laws — make informed decisions knowing consequences and challenges facing teachers without much support/direction from the Department of Education 2) Improve culture and climate so all students feel a sense of belonging and see they belong and are valued in WDMCS 3) Comply with laws as directed by legal counsel 4) Continue to speak from a stance of inclusivity 5) Advocate and be an ally for LGBTQIA students and families Elizabeth Larson: The best way to balance the needs of students and staff while complying with Senate File 496 is to follow the law as narrowly as possible We must comply with the law in order to protect our staff from dire consequences in order to limit the harm as much as possible we must not do one thing more than what is spelled out our state Legislature has stripped school boards of the local control that used to be so highly valued in Iowa it is my responsibility to ensure our school district adheres to the laws surrounding SF496 I firmly believe in the importance of exposing our students to a diverse range of authors and books all of which I believe can be selected in accordance with the legal requirements My commitment is to promote academic excellence and provide our students with the highest quality education possible Aaron Sewell: Teachers and staff are constantly navigating obstacles thrown at them and we do it anyway because of the passion we have to make the lives of our students better We as public school teachers are not new to the challenge of navigating curriculum or literature restrictions Clear communication from administration and families in conjunction with educator input can go a long way to understanding educational goals The biggest thing we can give students as teachers and families is time let them share themselves and support them Scott White: While bans on books should always be considered a last-step measure sometimes they are required from both a legal and moral perspective Certain well-publicized works with sexually graphic illustrations and vulgar language must be pulled from our district libraries There is still much literature available to our students that will excite their imagination as well as increase their understanding and respect of people from diverse backgrounds More: Des Moines suburban school boards gear up for elections on Nov. 7. Here's who is running: Michael Andreski: The first step is to work in collaboration with the municipal governments within the district to have as accurate projections of future growth as is possible the school district will need to be as flexible as possible in their planning needs assessments will need to be conducted as frequently as yearly and plans adjusted to reflect the evolving needs of the district Laurie Beilstein: If we don’t fix our lackluster proficiency rates School choice will meet the demand for academic excellence Jeff Hicks: Our district is fairly land-locked we simply won’t have the same growth as communities like Waukee and Ankeny Schools with declining growth inevitably face budget challenges we must be the open-enrollment school of choice and teachers and staff that are second to none Coupled with a diverse student body that reflects the nation our graduates will help lead I’m confident we’ll remain a district that families seek to join Jill Caton Johnson: WDMCS will continue to welcome families to our district Growth will need to match space available in our schools and programs We have made some facility improvements in elementary and junior highs that could allow us to accommodate growth in enrollment Discussions will need to happen regarding extra-curricular supports as student numbers increase We will also need to be mindful of keeping within our current board-mandated class capacity limits Attracting and retaining teachers will continue to be an area to address with a growing enrollment Elizabeth Larson: WDMCS has not seen the growth of other metro districts because our attendance areas are well-developed Stagnant growth has created its own problems with the state’s increases in per pupil funding not being enough to cover the cost of inflation This puts WDMCS in the position of needing to make cuts to afford the increasing costs of everything else To maintain academic excellence and continue to provide our students with extensive opportunities the district must seek outside support like community grant opportunities and maintain excellence in education that attracts students from around the metro to open enrollment Aaron Sewell: Districts are currently monitoring how the new law giving more freedom to the creation of charter schools will affect growth in the suburban districts long term So far it's been a minimal effect but here in West Des Moines it still is something to keep an eye on as we grow as a community Our public schools welcome every child through our doors and make every effort to help them achieve academically We must continue to look at the potential for adding to our school facilities to make sure they can effectively handle student influxes Closing campuses or facilities does not seem feasible long term Teri Patrick: Upon reviewing the historical enrollment data for the West Des Moines School District we have been experiencing an increase in students open enrolling but we are also seeing a decline in enrollment particularly among our resident students I believe we need to understand the reason students and their families are choosing to leave the district Our goal should not only be to retain our current students but also to enhance the district to make it the preferred choice for the families in our community certified enrollment in the West Des Moines School District has increased 1.166% which suggests that district enrollment has been pretty stable District enrollment projections indicate no looming increases over the next several years I believe the district is well prepared to manage potential future student growth MILTON, W.Va. (WCHS) — The case of a man accused of fatally shooting a family member in Miltonlast month has been sent to a Cabell County grand jury is charged with first-degree murder and wanton endangerment after a Dec The case was bound over Wednesday to a grand jury Kyle O'Dell with the Milton Police Department was one of the first at the scene that evening and testified Wednesday “I was told by dispatch that a man had been shot by his son and that he was still shooting at the time," O'Dell said on the stand police found Mark Beilstein collapsed near the front door of the residence suffering from gunshot wounds to the chest and right arm O'Dell said when police arrived at the scene was in the front door asking for an ambulance First responders began life-saving treatment but later pronounced him dead at the scene “We asked where the shooter was because at that time Chief Parsons was also there He was closer to the door," O'Dell said "She said he was out back and I went toward the right hand side and at that time is when Chief Parsons said Police took Jacob Beilstein into custody and learned from the victim’s wife that an infant was in the home at the time of the shooting Police found the child locked in an upstairs closet the mother gave a statement to police that said Mark came into the kitchen with a gunshot wound and said "He just killed me." The mother looked upstairs ,where she could see Jacob peeking around the corner Jacob remained upstairs throughout the shooting "It indicated that he was at the top of the steps and shooting down toward the victim," O'Dell said Officers testified Wednesday that Beilstein made no statements to police when asked if he wanted to talk and remained emotionless but he leaned back in his chair and kind of grinned at me and told me no and I confirmed with him," O'Dell said " 'You don’t want to talk to me without any attorney present?' and he said The officers said two guns were found on a bed in the home and the only thing Beilstein had on him when he was taken into custody was a blood-stained New Testament Bible Cabell County Magistrate Ron Miller said there was enough probable cause to send the case to the grand jury Cabell County assistant prosecuting attorney Payton Smith said that the state meets the burden of proof for not just the first-degree murder charge “The defendant also fired the same weapons in the direction of the victim and his wife which passed through the front of the house and could have injured or killed any passerby outside," Smith said Alert: It would appear that you are running an outdated browser. Please download a modern browser — The Slippery Rock University Alumni Association will honor four recent graduates at its Annual Awards and Recognition Banquet at 5 p.m. April 27 at the Russell Wright Alumni House The association will also honor a number of students with awards and scholarships a dual business administration in economics and professional Spanish major from Slippery Rock a sport management major from Spring Grove will be awarded the Outstanding Senior Man and Senior Woman Awards during the ceremony a 2009 accounting graduate.• Grace Evans a 2013 dual mathematics and nonprofit management graduate.• Adam Katchmarchi a 2012 health and physical teacher education graduate.• Elise Michaux a 2011 English literature graduate (undergraduate) and 2013 student affairs graduate (masters) The awards were created in 2005 by the SRU Alumni Association to recognize alumni that have demonstrated professional and personal accomplishments faculty and staff can nominate candidates for the awards Those nominated for the honor must be a graduate of SRU with a bachelor's and who have graduated within 10 years of the award's presentation began working in the accounting department at Earth Sun Moon Trading Company a successful gift and apparel business located in Grove City with $24 million in annual revenue he was promoted to his current position of controller where he oversees all aspects of the company's finances and manages the accounting department Beilstein is an avid cyclist who rides approximately 5,000 miles per year He uses his love of cycling to make a difference for others as an annual participant and organizer of the American Diabetes Association's Tour de Cure bicycle fundraising event in Pittsburgh His vast knowledge of local routes has proved invaluable in the creation of longer and safer routes for event participants Beilstein resides in Evans City with his wife Evans is a program associate at the Richard King Mellon Foundation in Pittsburgh where she contributes to the organization's mission of building a competitive future and quality of life in southwestern Pennsylvania Evans served as president of the Green and White Society was an active member in the then-Honors Program and the Student Nonprofit Alliance and worked as both a Pride Guide and a student assistant in the Center for Student Involvement and Leadership She also led and participated in service-learning programs domestically and abroad and won a Rising Star Award for community service Evans currently serves on the advisory council for the Philanthropy and Nonprofit Management Program at SRU she earned a master's degree in public policy from The University of Michigan before going onto serve as a Government Performance Lab Fellow at Harvard University's Kennedy School of Government Katchmarchi has dedicating his life to the education of future sport and recreation professionals; research to expand the field of drowning prevention and water safety; and service to national organizations that are focused on reducing drowning and aquatic injury An assistant professor and the aquatics director in the Department of Kinesiology Health and Sport Sciences at Indiana University of Pennsylvania he also serves as the executive director and chief executive officer of the National Drowning Prevention Alliance a 501(c)3 nonprofit focused on collaborative drowning prevention and water safety efforts Katchmarchi has received two "Power Awards" from Aquatics International including a "Next Generation Leader" in 2012 and being named one of the "Most Influential People in Aquatic Industry" in 2017 He has served on the board of directors for the National Drowning Prevention Alliance vice president and president as well as having served on the board of directors for the National Water Safety Congress Kachmarchi served as a CPR and swim instructor and was the founder of the Aquatics and SCUBA Club at SRU He earned a doctoral degree in coaching and teaching studies at West Virginia University Michaux is the director of student leadership and involvement at Seton Hill University she helped to develop and implement a comprehensive leadership program for students was recognized by JENESIS Magazine for her work with the Downtown Greensburg Project she was honored by NASPA's Center for Women during Women's History Month for her contributions to higher education Michaux earned a bachelor of arts in English Literature and a master's degree in student affairs in higher education While in graduate school she served as a graduate assistant for first year and transfer students and advised 20 first-generation low income and Pell grant recipient students While a student she served as the Student Government Association speaker of the senate vice president of the graduate student association Jude and advised the Chosen Generation Gospel Choir She was selected two consecutive years to represent SRU as part of the PASSHE annual advocacy day initiative currently serves as the president of the Slippery Rock Student Government Association works as a Pride Guide for the Office of Undergraduate Admissions and as a student worker in the Sport Management Department She has also served as the president of the Sport Management Alliance at SRU and the SRU chapter of Colleges Against Cancer She has also captured a number of other accolades including the 2018 College of Business Student Leader of the Year the 2017 Community Assistant of the Year Award and the 2016 Sport Management Underclassman of the Year Award She has volunteered with the American Cancer Society Special Olympics and the University's Office of Disability Services She took part in a service-learning trip to Petersfield Jamaica where she helped to renovate a community park Kline plans to pursue a graduate degree in student affairs and higher education has been in a variety of roles and capacities since he arrived at SRU fair trade learning coordinator and helping to reestablish the Zeta Alpha chapter of Theta Chi at the University Tuten serves as the vice president of health and safety and helped to formulate its Sacred Purpose initiative that addresses issues including suicide prevention and sexual assault prevention and awareness carrying out economic sustainability research; completed a sales marketing and operations internship with Creminelli Fine Meats an artisan meat company based in Salt Lake City Utah; was named the 2018 Pennsylvania Association of Colleges and Employers Student of The Year; and named Outstanding Senior Economics Major by SRU's College of Business Tuten plans to pursue a graduate degree in business or economics MEDIA CONTACT: Robb King | 724.738.2199 | robb.king@sru.edu has acquired the Beilstein Database from the Beilstein Institute for the Advancement of Chemical Sciences Elsevier has produced and marketed the database through an exclusive agreement with the Beilstein Institute It will now merge the database with the German arm of its MDL Information Systems subsidiary which already offers Beilstein data through its CrossFire Beilstein product Covering organic chemistry literature dating back to 1771 the database contains records of more than 9.8 million compounds and 10 million reactions as well as 320 million pieces of experimental data on chemical properties It also includes more than 900,000 abstracts from 1980 to the present as well as pharmacological and toxicological data on organic chemicals Elsevier says it has updated or added about 5 million compounds to the database during the nine-year partnership ACS’s Basic Package keeps you connected with C&EN and ACS $80 Regular Members & Society Affiliates ACS’s Standard Package lets you stay up to date with C&EN ACS’s Premium Package gives you full access to C&EN and everything the ACS Community has to offer Elsevier, the Amsterdam-based scientific publisher, has acquired the Beilstein Database from the Beilstein Institute for the Advancement of Chemical Sciences Since 1998, Elsevier has produced and marketed the database through an exclusive agreement with the Beilstein Institute. It will now merge the database with the German arm of its MDL Information Systems subsidiary It also has been building a customer base in the academic sector and in the pharmaceutical industry the publisher plans to further integrate chemical structure data and text information For its part, the Beilstein Institute intends to focus on its mission to advance the chemical sciences, says Director Martin J. Hicks. The institute's efforts emphasize information and communication, including symposia, software development, related research grants, and its open-access publication, Beilstein Journal of Organic Chemistry The Beilstein Database competes with services such as Thomson Scientific's ISI Web of Knowledge and Chemical Abstract Services (CAS), a division of the American Chemical Society Both have records dating back some 100 years ISI broadly covers about 230 scientific disciplines and includes 2 million chemical structures hold nearly 25 million abstracts of chemistry-related literature and patents and records on about 31 million chemical substances and 12 million reactions Sign up for C&EN's must-read weekly newsletter This article has been sent to the following recipient: Copyright © 2025 American Chemical Society This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page who has been living along Merrimack Boulevard since 2017 sees the construction of new townhomes right next door to her for about a year now - and is afraid of what they could possibly bring to her front yard "There's a lot of flooding in some areas and (when) these neighborhoods get built they don't really take into consideration where that water is going to go." Beilstein says when it has rained in the past water comes on to the streets washing dirt on to the roads She believes the new development won't help the problem (the water is) going to go right on to my property and flood my garage and driveway," Beilstein said but it depends on how much rain we're going to get." it appears that on-site and off-site stormwater concerns were adequately addressed." The approved plans show the entire subject property will catch and release the drainage to the two ponds the property will have installed This is accomplished with catch basins in the proposed roads and underground pipes running from various points around the property leading to the central and southern stormwater devices The vast majority of water from the site is designed to flow south (away from 119 Merrimack Blvd) to the central pond before discharging at the southern edge of the property into an existing 45-foot drainage easement Beilstein hopes it won't change the area she loves "I'm not looking forward to it," she said "I do really enjoy my neighbors and my home but I feel like the town hasn't really taken into consideration that they're ruining our neighborhood for a little bit of money." Barnhart’s School Board of Trustees informed their parent community today that on September 1 the Board received a letter of resignation from Ethan Williamson who was the Head of School for four years Williamson recently learned of a new grandbaby on the way and is planning to relocate to the Sacramento area to be closer to his family instituting Barnhart traditions such as the San Gabriel Valley Scholar program increasing experiential field study programs and much more Williamson thanked everyone for the opportunity to serve Barnhart and said “I will cherish the time I spent at the school.” He has offered his services to the Board of Trustees as an advisor during this time of transition filled with teachers and parents who bring out the best in their students and children balancing academic excellence with amazing inspiration It is an honor and privilege to become Barnhart’s interim leader.” the Board of Trustees is initiating a nationwide search process to identify and hire the next Head of School While Beilstein is throwing her hat into the ring for the Head of School consideration she has also encouraged the Board to initiate an executive search to secure the best fit possible to propel Barnhart’s future Learn more about the Pasadena area's finest private schools Beilstein.3/23/2010 12:00:00 AM | Women's Gymnastics The Weekly Warmup with Natalie Beilstein10/18/2012 12:00:00 AM | Women's Gymnastics MGoBlue.com's Brad Rudner will sit down with each member of the University of Michigan women's gymnastics team to talk about the preseason training and what lies ahead for the 2013 season This week's edition of the Weekly Warmup features senior Natalie Beilstein (Butler Brad: How difficult was it for you to see your teammates go through the struggles of last season knowing that you couldn't help them due to your injury Natalie: It was probably one of the most difficult things I've ever been through in my gymnastics career so being out for the whole year was definitely hard and it was hard to see the team struggle a little bit We really pulled it together at the end and had one of our best meets at Regionals It was exciting to see us compete like that despite the adversity and really show everyone what we could do Brad: Looking back at really the last 8-10 months what has been the more difficult phase of your rehab -- the physical aspect or the mental Natalie: I would say it's been both it's hard to stay in shape when you're not doing gymnastics and are not fully out there 'What if I go out there and hurt myself again?' or something like that I told myself that those things weren't going to happen The team retreat really helped me in that sense That was something I threw away into the fire and something I've been working on you are back now and you're doing some things Where are you at in terms of your recovery and how do you feel Natalie: I feel great at this point but it just sort of depends on what I do in the gym that day If we do a lot of hard tumbling or vaulting I'll be sore so I'll maybe take it a little easier the next day I've been learning some new things on floor I really like that routine and was only able to do it once last year I've actually been working on a new series I'll be going back to doing a one-and-a-half I'm looking to do bigger and better gymnastics Brad: The people I've talked to so far have all said that team chemistry has been very good A big part of that is integrating the freshmen into college life and making sure they fit in to their new team Have you taken more of a mentoring role this preseason This year is different than anything I've experienced the past three years We have all four classes and the freshmen have been great I've been hanging out a lot with Austin Sheppard I guess you could call her my "right-hand" woman Having four years of classes has definitely helped our friendships grow We've really progressed as a team and I think you'll see that this year out on the floor Natalie: I envision it going pretty well Last year was a struggle and we all know that -- but it taught us that even if we have struggles my individual goals aren't set in stone yet but I want to stay healthy and be ready to help the team out whenever they need me We're really excited to get back out there I think people will be shocked to see how we are this year We're going to come out of the gates strong Michael Beilstein is a Green Party Candidate running for Oregon's 4th Congressional District in the US House of Representatives More about Beilstein and his campaign can be found here. We're asking candidates to complete a questionnaire about themselves and their positions I am a retired chemist who worked at Oregon State University in Corvallis for 30 years I was a high school teacher in the Peace Corps in Lesotho for two years after graduating with a BA in Biochemistry I worked briefly at Medical College of Virginia and Johns Hopkins before coming to Corvallis I obtained an MA in human nutrition while working at Oregon State University I became interested in public affairs during the first Gulf War and was active in peace and social justice campaigns since the 1990s I served on the Corvallis City Council for 12 years I have run for US Congress as the Pacific Green candidate four times I am running to build support for the Pacific Green Party The international Green movement is founded on the four pillars of Nonviolence Greens at all levels of government and in every country represent these values By campaigning and appearing on the ballot I can bring to public attention the gap between USA militarist/colonial/imperialist policy and the values held by the people WHY SHOULD PEOPLE WHO LIVE IN YOUR CONGRESSIONAL DISTRICT VOTE FOR YOU I am providing an opportunity for ethical voters to vote against the militarism sexism and classism that characterize our political economic system A vote for any Green candidate is a vote to reduce military/intelligence spending to provide medical and educational services to all people to reverse the environmental holocaust perpetrated by our consumerist society and to end the rule of society by corporate oligarchs My experience as a Corvallis City Councilor involved legislation consulting with constituents and creating a community vision I believe I excelled in maintaining collegial and cordial relationships with elected officials I anticipate the same compassionate attention to service on the broader scale of the US Congress WHAT'S THE NUMBER ONE ISSUE FACING YOUR DISTRICT RIGHT NOW Climate change is the primary issue facing the human race Ending the ecological destruction that endangers the future of humanity requires rapid changes in the US and world economies We need a price on carbon emissions to deter consumers and producers of green house gases and must quickly invest in alternative non-polluting energy generation Transportation and agriculture must adapt to a new low energy technologies Oregonians must reject new fossil fuel investment especially the proposed Jordan Cove liquid natural gas export facility Forests must be managed to maintain healthy ecosystems and support a sustainable housing industry The imperialist military adventures of the USA must cease WHAT MAKES YOU DIFFERENT THAN THE OTHER CANDIDATES FOR CONGRESS IN YOUR DISTRICT I am not a representative of the oligarchs who have seized control of the two major political parties I represent realistic solutions to the dead-end that capitalism has brought us to I am part of a political party and an international movement that stands for non-violence BEILSTEIN'S POSITIONS ON SOME MEASURES ON THE 2018 OREGON BALLOT: - REMOVING OREGON'S SANCTUARY STATE STATUS The Oregon law requiring non-cooperation with federal immigration enforcement was passed to prevent police profiling of ethnic minorities US immigration laws are designed to maintain an under class of workers who lack the protection from exploitation Oregonians must reject the attempt to further exploit workers and scapegoat hard working immigrants as the cause of economic stagnation - THE PROPOSED CONSTITUTIONAL BAN ON STATE FUNDING OF ABORTIONS should be made by consumers and their providers There should be no interference by outside influences High quality health care should be available to all Oregon residents - THE PROPOSED CONSTITUTIONAL BAN ON GROCERY TAXES The proposal to ban grocery taxes is an example of the abuse of the Oregon initiative process by moneyed interests who can pay signature gatherers and marketing experts to frame initiatives to appeal to base instincts of uninformed voters Creating bans on future legislation reduces democracy ARE YOU IN FAVOR OF PUTTING TOLLS ON I-5 AND I-205 I believe our profligate use of motorized transportation is part of the problem of overconsumption that is leading the world to irreversible ecological collapse Requiring motor vehicle users to bear the full cost of petroleum production and consumption will reduce the need for other restrictions on highway usage I support the Citizens Climate Lobby proposal for a rising carbon fee and dividend as a necessary and humane means of moving the economy toward more rational transportation technology DO YOU THINK MEMBERS OF CONGRESS ARE LIVING UP TO THEIR RESPONSIBILITIES RIGHT NOW Congress and the executive and judicial branches of our government have been taken over by oligarchs who will not allow our leaders to act in the interest of the people We have an economy growing through super-exploitation of workers and the natural environment on which our civilization depends All the benefits go to the wealthiest one percent of the one percent Any member of Congress who threatens the rule of the oligarchs can be removed by a massive infusion of “dark money” into smear campaigns and unlimited financial support for more pliable representatives WHAT WOULD YOU DO TO HELP INCREASE BIPARTISANSHIP IN CONGRESS Getting the money out of politics would allow representatives to actually represent their constituents rather than their funders I will introduce legislation for public funding of campaigns and an end to private political bribery WHAT CONCERNS YOU THE MOST ABOUT THE CURRENT POLITICAL CLIMATE Fidel Castro is the greatest political leader in modern history His creation and leadership of a successful anti-imperialist resistance to exploitation of Cuba is an inspiration to all oppressed people of the world WHAT QUESTION DO YOU WISH SOMEONE WOULD ASK YOU What is your plan for countering and mitigating climate change This is a question which every candidate for elected office must be asked WHAT’S THE BEST PIECE OF ADVICE THAT YOU’VE EVER RECEIVED Grant me the serenity to accept the things I cannot change; courage to change the things I can; and wisdom to know the difference My favorite place in Corvallis it the elm lined path through the lower campus of Oregon State University that connects the school and downtown I walked this path regularly and it still gives me a spirit of calm and relaxation as I pass through it I am hopeful for an end to the semi-professional college football system Intercollegiate football detracts from the academic mission of both Oregon State University and University of Oregon They would be better schools without PAC-12 sports Health Care Heroes Community College of Baltimore County's 18th annual gala Top Trump administration leaders are debating whether to invoke a “state secrets privilege” in response to[...] The 40th annual Stella Maris Crab Feast and Hospice Day of Giving raised approximately $110,000 in support of [...] [caption id="attachment_715191" align="aligncenter" width="900"] Federal Reserve Board Chairman Jerome Powell [...] the union for 45,000 dockworkers and the group representing East and Gulf Coas[...] manages and distributes funds to support Howard Count[...] Sign up for your daily digest of Maryland news Supporting small businesses is an investment in Maryland’s prosperity – one that drives growth a[...] Listen to this article As I write this shortly after Earth Day 2025 I have on my desk a 46-page pub[...] Listen to this article Based on recent data provided by the U.S there was a si[...] I took the oath prescribed in Maryland Business Occupations[...] Listen to this article Maryland has a lot to celebrate when it comes to climate action but also muc[...] Lawmakers in Annapolis have passed hastily considered extended [...] Listen to this article In the past decade employers who sponsor pension plans have been subject to [...] Submit an entry for the business calendar The Daily Record is a digital-first daily news media company focused on law Get our free e-alerts & breaking news notifications Subscribe for access to the latest digital and special editions Click here for information about plaques permissions and reprints of previous editions Javascript is disabled in your web browser You can't access site without javascript so please enable it for your seamless and unintruppted user experience of our website Barnhart School is preparing for the year ahead with an engaging and adventuresome curriculum The school is celebrating six decades of service to local families “Barnhart is just a beautiful place filled with all kinds of excitement and energy this year,” said Tonya Beilstein “We continue in our 61st year of providing a balanced education to students but we recognize that our students are often more than their academic selves.” There is an element of wanderlust in the curriculum as trips are centered around a learning opportunity “We’re really focusing on helping to build some amazingly beautiful humans to go out and make a difference in the world,” Beilstein said “Our mission is that we grow difference-makers and we believe we do that by connecting with our students in a really wonderful way and by focusing on the social emotional development of our students in addition to their academic growth.” Barnhart announced the hiring of new Assistant Head of School “She brings a wealth of experience in independent schools and learning in the upper elementary and middle school years,” Beilstein said “And she certainly has a passion for elementary age as well.” Beilstein said the school works to “make sure that the teachers have what they need so that we can make sure our students have what they need to be successful every day.” “We start even in kindergarten with just day trips or short explorations so that students can really start developing those independent skills,” she said adding the object is to have experiences “outside the four walls of a classroom” that relate to the learning the students will take a one-night overnight and then in fifth grade we expand that,” Beilstein said “They’ll be gone for a couple more nights Our fourth graders go down to Dana point and stay overnight sixth and seventh graders are going to Yosemite and eighth graders go to Washington DC she said Beilstein added that it’s time now to consider your educational options for the 2020-21 school year “Our admissions season is in full swing and we believe in demonstrating to prospective families an authentic view of Barnhart and who we are which is a community that values its personal connections,” she said “So we do small group tours that allow us to personalize the admissions process but actually we’ve even completed a few tours already because folks are interested.” The school is conducting tours and invites parents to inquire For more information see the Barnhart Website A man was charged in connection with the shooting death of a family member at a Milton residence Thursday has been charged with first degree murder and wanton endangerment involving a firearm according to a criminal complaint filed in Cabell County Magistrate Court The complaint said officers were dispatched to a residence on Woodmire Drive about 3:20 p.m Police found Mark Beilstein collapsed near the front door of the residence suffering from gunshot wounds to the chest and right arm Officers reported EMS workers began lifesaving techniques but later pronounced the victim dead at the scene Police were able to take Jacob Beilstein into custody and learned from the victim’s wife that an infant was in the home at the time of the shooting Beilstein is being held at Western Regional Jail without bond Milton police said a suspect was in custody Thursday after a fatal shooting at a home Police responded to Woodmire Drive – located off Interstate 64 - after multiple shots were fired inside a house They said a man was found collapsed inside the door No charges had been filed against the suspect as police were still evaluating the circumstances that led up to the shooting Police said the situation involved two family members "It’s an isolated incident,” Milton Police Chief Joe Parsons said There is no threat to the immediate neighborhood Parsons said the incident was very out of character for the neighborhood and he would have extra patrols on the evening shift just to make neighbors feel safe Cabell County 911 dispatchers reported a fatal shooting Thursday afternoon in Milton Dispatchers confirmed that a person was shot and killed on Woodmire Drive No more details about the shooting were immediately available This is a developing story and will be updated as more information becomes available BEAVER FALLS -- Horns will blare and pageantry will abound as local marching bands entertain the crowd at the 39th annual Beaver County Invitational on Oct Twelve area high school bands are on the bill which have previously performed at the festival will not be in attendance because of schedule conflicts The Geneva College marching band will punctuate the invitational with a performance at the end of the evening The event remains one of the highlights of the marching season for many participants Central Valley band director Wendy Lewis looks forward to showcasing her group’s talents She and her staff begin preparing for the marching season in the months prior to the summer and the students start getting ready for this event with June rehearsals “This festival is a time for us to showcase the halftime show we spent hundreds of hours preparing and we get to support every other local band program that has put in the same time and dedication,” Lewis said the Central Valley marching show will feature tunes such as Bach’s “Toccata and Fugue in D Minor,” Mussorgsky’s “Night on Bald Mountain,” Hinder’s “All American Nightmare,” and Aerosmith’s “Dream On." “Marching season is by far the most visible time for a school band program," Lewis said "In addition to the Beaver County Invitational it would be wonderful to see even more community members at other concerts musicals and festivals throughout the school year.” New Brighton band director Jamie Beilstein is also demanding of her students in each rehearsal and performance Her band’s marching show is comprised of 1950s rock and roll music Beilstein chose this theme based on the arrangements’ ability to showcase various instruments as well as expose the students to music they may not have heard before “I have very high expectations for the band," Beilstein said "The students know that they have to work hard We not only focus on the ‘big picture’ of the show but also work to make sure the details of the marching and color guard routines are executed with precision.” The New Brighton band annually hosts the Beaver County Invitational and much more are carried out by numerous parent volunteers Medic Rescue and many local sponsors also help to keep the festival in motion Each band will be different from the next; some will be show-style and designed to please any crowd “I think marching band continues to be a popular activity in Beaver County because music is enjoyable and for many students it’s why they come to school each day no one sits on the bench; every person has an important role.” Jamie Marie Rapp of Ambridge and Matthew Richard Beilstein of Slippery Rock were married Aug The bride is the daughter of James and Mary Ann Rapp of Ambridge The groom is the son of Rick and Angela Beilstein of Slippery Rock Bridesmaids were Hillary Williams of Beaver Jessica Smeltz of Economy and Kori Shearer of Ambridge Groomsmen were Chris and Matt Taggert of Slippery Rock Greg Barker of Pittsburgh and Ryan Benton of Arizona A reception was held at the Multi-Purpose Room at Slippery Rock University Campus The bride is a graduate of Ambridge Area School District and Slippery Rock University She is employed as a teacher in the New Brighton School District Her husband is a graduate of Slippery Rock School District and Slippery Rock University He is a software engineer and employed at Joy Mining Machinery which allowed college athletes to profit from a brand leveraging their name image and likeness for marketing and promotion hundreds of thousands of NCAA student athletes across the country have signed profitable brand deals including some student athletes at Dartmouth While the Ivy League strictly prohibits sports-based scholarships as a member league they are still forced to comply with the NCAA’s NIL policy.  with an undergraduate enrollment of just over 4,400 students the school’s D1 and Ivy League status make it a target for national brands that rely on name recognition Dartmouth’s brand-savvy athletes have adapted to the new NIL climate an outfielder for the women’s softball team entered Dartmouth with “an ambition to do brand deals.” With a strong interest in pursuing social media and marketing as a career post-college Panu feels that doing brand deals as a student-athletes is a “package deal,” helping her grow her personal and professional brand and profit off her athletic success and started a student ambassador partnership with Aquaphor earlier this year.  “I have about 5,000 followers on Tiktok and 5,000 on Instagram which has definitely helped with my deals,” Panu said Quarterback Jackson Proctor ’24 said his experience with NIL deals started by reaching out to companies with products he’s enjoyed for much of his life He has less of an interest in marketing as a profession but wants to support products he personally uses a drink he has enjoyed since middle school in late 2022 after reaching out to the company TYR Sports — an athletic apparel company — and LVLA — a lifestyle clothing brand that often sells items with positive mentality quotes — reached out to him about deals Proctor said he really enjoys his partnership with LVLA “I love being able to get LVLA’s [wrist] bands for a bunch of my friends … they’re really helpful for motivation in times of need,” Proctor said “Working with products I genuinely liked before the deal makes promoting them a lot easier.” Another popular avenue of promotion for student athletes is becoming a Barstool Athlete athletes are given a free T-shirt and are required to include “Barstool Athlete” in all social media bios being a Barstool Athlete grants them access to TwoYay a platform that connects companies to student athletes While becoming a Barstool Athlete itself doesn’t make students money it increases their visibility for brand deals the TwoYay platform allows companies to reach out to different athletes,” Proctor said “Being at an Ivy League school is an avenue some companies definitely want to pursue Once athletes establish some deals through TwoYay independent negotiations for deals are easier to come by Proctor mentioned he has another deal in the athletic recovery space forthcoming this time coordinated through Instagram DM.  has had similar experiences through a partnership with his hometown personal trainer a portable recovery device company called Firefly Recovery Technology and Powerade he emphasized the difficulty of doing these deals at a small “[Doing NIL deals] at Dartmouth is a little different because there are not as many local opportunities as there are at other [universities],” Ayers said athletes need to seek opportunities outside of that In addition to Dartmouth’s rural location and small size its status as a member of the Ivy League means athletes have to contend with specific Ivy League regulations such the requirement that athletes  report their deals to their respective schools’ compliance offices These can be different compared to schools that are part of the Power 5 leagues —  the five most prominent athletic conferences in the league — that may be recruiting athletes largely on a NIL basis The lack of athletic attention compared to schools in the Power 5 conferences may also mean less marketing potential for athletes.  some student athletes have found ways to successfully overcome these challenges though each approached their deals from slightly different angles Each of them also progressed to securing partnerships with national-facing brands.  Proctor also stressed how much his coaches and the College’s compliance team have helped facilitate these deals.  “The coaches are very helpful in making sure we are following rules and guidelines,” Ayers said we can run our deals through compliance before signing which ensures all rules [are] being followed.” Although these three athletes are a part of this initial wave of Dartmouth NIL deals as long as these deals remain permissible by the NCAA Panu and Proctor all had advice and enthusiasm for helping fellow student athletes at Dartmouth negotiate deals of their own “Reach out to companies that you may think won’t reach back Proctor emphasized the upside of participating in NIL deals as a student “I think these deals will help me down the road because I’ve been in contact with these different companies,” Proctor said he wants to make sure younger players understand the commitments they’re making especially with all of [University] of Utah’s scholarship football players getting new trucks to lease NIL deals are gaining traction and media attention,” Ayers said My best advice is to know what you are signing up for before agreeing As brands sign more collegiate athletes and the NIL policy continues into its third year there will undoubtedly be new challenges and expectations to navigate receive free products and earn a commission may continue to grow So the question remains: how will they take advantage of them Metrics details Expansion of the cytochrome P450 gene family is often proposed to have a critical role in the evolution of metabolic complexity the molecular mechanisms underlying the evolution of this complexity are poorly understood Here we describe the evolutionary history of a plant P450 retrogene which emerged and underwent fixation in the common ancestor of Brassicales before undergoing tandem duplication in the ancestor of Brassicaceae Duplication leads first to gain of dual functions in one of the copies Both sister genes are retained through subsequent speciation but eventually return to a single copy in two of three diverging lineages In the lineage in which both copies are maintained the ancestral functions are split between paralogs and a novel function arises in the copy under relaxed selection Our work illustrates how retrotransposition and gene duplication can favour the emergence of novel metabolic functions Available data indicate that both CYP98A8 and CYP98A9 catalysed the first meta-hydroxylation of the phenolic ring of pollen constituents (3′-hydroxylation of N1,N5,N10-tri-coumaroyl-spermidine) and that CYP98A8 also catalysed the second (5′-hydroxylation of N1,N5,N10-tri-feruloyl-spermidine) The recent emergence of this pathway and the sequencing of a representative set of Brassicales genomes offers the opportunity to determine the evolutionary process leading to these new P450 functions We show here that the founding retroposition leading to the CYP98A8 and CYP98A9 common ancestor occurred before the divergence of Cleomaceae and was followed by a duplication before the divergence of the core Brassicaceae lineages We demonstrate that the fate and function of the resulting paralogs differ between the Brassicaceae lineages the other maintaining a dual function in lineage II and III or conservation of the two gene copies in lineage I with subfunctionalization and gain of an additional activity in flavonoid metabolism by one of the duplicates (a) Annotated protein maximum likelihood tree illustrating the phylogenetic relationships in the CYP98 family in Brassicales The CYP98A3 clade is the parent to CYP98A8/9s Evolution regimes (ω=dN/dS) computed with codeml Branch model and acting on different phylogenetic groups are indicated Branch support in the tree was calculated from 1,000 bootstraps replicates (b) In vitro assay of CYP98A8/A9 enzymes activities Tri-coumaroyl-spermidine and tri-feruloyl-spermidine were used to assess the 3′- and 5′-hydroxylase activities of yeast-expressed proteins CYP98A8/A9 from all species have 3′-hydroxylase activity Only CYP98A8 from Brassicaceae have 5′-hydroxylase activity (c) Search for sinapoylated (m/z 207) phenolamides by parent ion scan analysis of flower buds demonstrates the absence in vivo of the tri-hydroxylated phenolamide di-(hydroxyferuloyl)-sinapoyl-spermidine (m/z 736) in A while it is present in Brassicaceae from lineages I Colour of each profile is according to the lineage colour code in a indicating that CYP98A9 had been present and was subsequently lost from the genome The presence of a fragmented CYP98A9 confirms the duplication history inferred from the gene tree the tandem duplication event that gave birth to CYP98A9 predates the split between sister lineages I In vitro assays revealed that: (1) the CYP98A8/9 protein from Adenium arabicum and T hassleriana catalysed only 3′-hydroxylation of tri-coumaroyl-spermidine; (2) the radiation of core Brassicaceae was preceded by acquisition of the 5′-hydroxylase activity shown by the ability of CYP98A8 from Eutrema salsugineum (lineage II) and A thaliana (lineage I) to catalyse both 3′-hydroxylation of tri-coumaroyl-spermidine and 5′-hydroxylation of tri-feruloyl-spermidine; (3) A thaliana CYP98A9 has 3′- but not 5′-hydroxylase activity our in vitro data suggest that 5′-hydroxylase activity evolved in CYP98A8 we inferred that the single CYP98A8/9 copy in the ancestor of both Brassicaceae and Cleomaceae lacked 5′-hydroxylase activity the single CYP98A8 copy present in lineages II and III performed both 3′- and 5′-hydroxylations This finding is also supported for lineage I species by the ability of A thaliana CYP98A8 to catalyse both reactions in vitro Both sets of analyses thus concurred to indicate that the acquisition of 5′-hydroxylation occurred in the ancestor of core Brassicaceae the gene duplication that gave rise to CYP98A9 remained an open question (a) The anther-specific phenolamide pathway as previously delineated in A thaliana flower buds shows that phenolamide intermediates downstream of N1,N5,N10-tri-coumaroyl-spermidine are absent from the cyp98a9 mutant indicating that CYP98A8 does not perform the 3′-hydroxylation in vivo: (b) N1,N5,N10-tri-coumaroyl-spermidine (d) N1,N5,N10-tri-(hydroxyferuloyl)-spermidine (e) N1,N5-di-(hydroxyferuloyl)-N10-sinapoyl-spermidine Reversible activity of the spermidine:hydroxycinnamoyl transferase acting upstream of CYP98A9 presumably accounts for the lower accumulation of the N1,N5,N10-tri-coumaroyl-spermidine in the cyp98a9 mutant compared with the accumulation of N1,N5,N10-tri-feruloyl-spermidine in cyp98a8 failed to detect a significant signature of positive selection along any branch of the tree and/or sequence sites (a) AtCYP98A8 and (b) AtCYP98A9 co-expression networks AtCYP98A9 is associated with two distinct co-expression clusters (c) Hierarchical clustering of genes involved in the different co-expression networks Each element of the matrix represents the expression potential of a given gene (column) in a defined anatomic compartment (line) Blue arrowheads indicate flower- and male reproductive tissue-related samples Red arrowheads indicate seed-related samples (d) Analysis of pCYP98A8:uidA and pCYP98A9:uidA expression patterns in opening flowers and green seeds thaliana transgenic lines expressing CYP98A8/A9 genes under control of the A Only expression of lineage I CYP98A9 leads to a transparent testa (tt) phenotype Ler: wild-type Arabidopsis Landsberg erecta tt4-1: transparent testa 4 mutant for the chalcone synthase gene (b) In vitro enzyme assays showing the CYP98A9-dependent conversion of naringenin into eriodictyol Assays with (+) and controls without (−) NADPH were performed Eriodictyol (grayed elution time) was detected using the m/z 289.4>153.0 transition in multiple reactions monitoring (MRM) positive mode (c) Relative naringenin hydroxylase activity (% relative to highest activity set to 100) (a) Docking of S-naringenin in the AtCYP98A9 active site Trp109 and Lys209 anchor naringenin for B-ring 3′-hydroxylation (b) Lys209 substitution with alanine or isoleucine reduces AtCYP98A9 naringenin hydroxylase activity in vitro (c) Fitmodel reconstitution of the history of the selection pressure on the AtCYP98A9 Lys209 codon The most frequent codon and amino acid are indicated on branches It thus can also be postulated that the new function of CYP98A9 contributed to its retention in lineage I (a) Initial steps of the CYP98A8/9 evolution shared by lineages I The initial CYP98A3 retroposition event in Brassicales (100-70 Ma) led to the CYP98A8/9 ancestral gene The retroposition was followed by a tandem gene duplication in Brassicaceae around 45 Ma leading to the CYP98A8 and CYP98A9 sister genes CYP98A8 then acquired an additional function (b) Further evolution of CYP98A8 and CYP98A9 in the lineage I of the Brassicaceae CYP98A8 lost the phenolamide 3′-hydroxylase activity in vivo and maintained only the 5′-hydroxylase activity CYP98A9 maintained the 3′-hydroxylase activity and simultaneously gained naringenin 3′-hydroxylase activity (c) Further evolution of CYP98A8 and CYP98A9 in the lineages II and III of the Brassicaceae and CYP98A8 maintained both 3′- and 5′-hydroxylase activities salsugineum grown under controlled conditions were harvested grandiflorum were sampled in the botanical garden of the University of Strasbourg Transgenic plants were selected on soil via Basta treatment (250 mg l−1; Agro Evo) T2 seeds were used for subsequent analyses tenella with published whole-genome sequences from Brassicaceae lineage I and II species PCR products were separated on a 1% agarose gel with low EDTA before excision filtration (Millapore Centrifugal Filter Units) Purified PCR products were ligated into pGEM-T Easy vector (Promega) and transformed into TOP10 competent cells and plated on selective media for screening Positive transformants were cultured overnight in liquid media and plasmid DNA harvested using an alkaline lysis kit (Zymo Research) Cloned fragments were sequenced in both directions to achieve a minimum of 85% overlap Overlapping sequence reads were assembled into a consensus sequence using the software Geneious v was transformed with pYeDP60 vectors and selected on minimum SGI medium (1 g l−1 bactocasamino acids 20 g l−1 glucose and 40 mg l−1 L-tryptophan) Liquid cultures were initiated from selected colonies grown on SGI for 18 h at 28 °C under agitation (160 r.p.m.) Ten milliliters of SGI culture were used to inoculate 200 ml of YPGE (10 g l−1 bactopeptone recombinant proteins production was induced by supplementing the medium with 10 ml of 200 g l−1 galactose and further incubation at 20 °C for 16 h Yeast cells were harvested by centrifugation at 7,500g for 10 min at 4 °C washed with TEK buffer (50 mM Tris-HCl pH 7.5 100 mM KCl) and resuspended in 2 ml of TES (50 mM Tris-HCl pH 7.5 600 mM sorbitol) supplemented with 5 mM 2-mercaptoethanol and 10 g l−1 bovine serum albumin Cell suspensions were transferred to 50 ml conical tubes and homogenized with 0.5 mm glass beads by handshaking five times for 1 min each Beads were washed twice with 30 ml of cold buffer A Cell debris and remaining glass beads were removed from the pooled lysates by 20 min centrifugation at 7,500g and 4 °C Supernatant was filtrated on Miracloth (22–25 μm pore size Maryland) and microsomal fraction pelleted by centrifugation at 100,000g and 4 °C for 1 h Pelleted membranes were resuspended in TEG buffer (50 mM Tris-HCl pH 7.5 30% glycerol by volume) with a Potter-Elvehjem homogenizer Microsomal membranes were stored at −20 °C until processing activity was normalized to the activity recorded for the same enzyme with tri-p-coumaroyl-spermidine and expressed as a percentage of the maximal activity Dry residues were re-suspended in a 50% methanol solution containing 2 N HCl and 2.5 mg ml−1 ascorbic acid as an antioxidant Acid hydrolysis was performed at 80 °C for 2 h Samples were cooled down before UPLC-MS/MS analysis All Modeller and Autodock calculations were performed using the computing facilities of the CEA-DSV (cluster Gabriel) at Saclay The final model was the best one according to a good compromise between the scores calculated by the SAVES server scoring programs and the QMEAN value the selected AtCYP98A8 and AtCYP98A9 models had a QMEAN score equal to 0.701 and 0.689 which are good scores when compared to the QMEAN scores of individual PDB templates The atom charges of the proximal thiolate were taken from the same work was parametrized under Maestro 9.2 (www.schrödinger.com) molecular modelling suite and the structure saved under MOL2 format as input files for AutoDock Partial charges were assigned using OPLS 2005 force field but several conformations of the non-aromatic ring have been generated as starting point for docking to allow better conformational sampling under Autodock 4 since the algorithm cannot handle ring flexibility created in Chimera for the receptor and Maestro for the ligand were converted into the PDBQT format file by AutoDockTools which merges all nonpolar hydrogen atoms to the carbon atoms they are bonded to The default settings were used for all other parameters whereas the docking computational conditions were identical for both isoforms the solutions found for AtCYP98A9 are gathered in the same cluster within 2 Å of root mean square deviation of clustering while the histogram of AtCYP98A8 displays a more scattered profile the most negative) energetic binding scores were well-resolved in the histogram of scores for AtCYP98A8 but corresponded to non-productive metabolism positions All clusters under −4 kcal mol−1 were independently investigated for their consistency with productive position for 3′-hydroxylation reaction The data that support the findings of this study are available from the corresponding author upon request tenella have been deposited in GenBank with accession codes KX754460 and KX754461 Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism Evolution by Gene Duplication Springer Verlag (1970) The evolutionary fate and consequences of duplicate genes Genetic content and evolution of adenoviruses The evolution of gene duplications: classifying and distinguishing between models The evolution of functionally novel proteins after gene duplication Preservation of duplicate genes by complementary On the possibility of constructive neutral evolution Escape from adaptive conflict after duplication in an anthocyanin pathway gene Gene duplication and the adaptive evolution of a classic genetic switch Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict Protein moonlighting: a new factor in biology and medicine An evolutionary perspective on protein moonlighting Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution Evolution of the telomere-associated protein POT1a in Arabidopsis thaliana is characterized by positive selection to reinforce protein-protein interaction The Origins of Genome Architecture Sinauer Associates Sunderland (2007) Evolution of a novel phenolic pathway for pollen development CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters a missing link in the phenylpropanoid pathway The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism The origin and evolution of lignin biosynthesis ABORTED MICROSPORES acts as a master regulator of pollen wall formation in Arabidopsis Dated molecular phylogenies indicate a Miocene origin for Arabidopsis thaliana The Tarenaya hassleriana genome provides insight into reproductive trait and genome evolution of crucifers The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) Adaptive protein evolution at the Adh locus in Drosophila Comprehensive developmental profiles of gene activity in regions and subregions of the Arabidopsis seed Cinnamate-4-hydroxylase expression in Arabidopsis Regulation in response to development and the environment The transparent testa 4 mutation prevents flavonoid synthesis and alters auxin transport and the response of Arabidopsis roots to gravity and light Genetics and biochemistry of seed flavonoids Flavonoids as important molecules of plant interactions with the environment Flavonoids and the regulation of seed size in Arabidopsis An archived activation tagged population of Arabidopsis thaliana to facilitate forward genetics approaches Over-expression of F5H in COMT-deficient Arabidopsis leads to enrichment of an unusual lignin and disruption of pollen wall formation Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana High-efficiency thermal asymmetric interlaced PCR for amplification of unknown flanking sequences Brassicaceae phylogeny and trichome evolution How to usefully compare homologous plant genes and chromosomes as DNA sequences Advancing uracil-excision based cloning towards an ideal technique for cloning PCR fragments Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5 Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana Toward genome-wide metabolotyping and elucidation of metabolic system: metabolic profiling of large-scale bioresources AtMetExpress development: a phytochemical atlas of Arabidopsis development An improved clearing method for GUS assay in Arabidopsis endosperm and seeds Arabidopsis microarray database and analysis toolbox MUSCLE: multiple sequence alignment with high accuracy and high throughput New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building PAML 4: phylogenetic analysis by maximum likelihood Modeling the site-specific variation of selection patterns along lineages Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments Comparative protein modelling by satisfaction of spatial restraints Comparative protein structure modeling using MODELLER MUSTANG: a multiple structural alignment algorithm MAFFT multiple sequence alignment software version 7: improvements in performance and usability QMEAN: A comprehensive scoring function for model quality assessment QMEAN server for protein model quality estimation UCSF Chimera--a visualization system for exploratory research and analysis New AMBER force field parameters of heme iron for cytochrome P450s determined by quantum chemical calculations of simplified models 3rd Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility A new Lamarckian genetic algorithm for flexible ligand-receptor docking Download references We are grateful to Clint Chapple (Purdue university is grateful to the China Scholarship Council and the Région Alsace for co-funding a PhD scholarship acknowledge the support of the Agence Nationale pour la Recherche to the PHENOWALL ANR-10-BLAN-1528 project and of the Freiburg Institute for Advanced Studies (FRIAS) and the University of Strasbourg Institute for Advanced Study (USIAS) to the METABEVO project Université Paris Descartes) for help in model structures set-up and the staff of the computing facility of the Commissariat à l'Energie Atomique (CEA/DSV/GIPSI Saclay) for help and access to the national cluster Gabriel A portion of this work was supported by a grant (MCB 1409251) from the National Science Foundation of the United States to M.A.B Present address: Present address: Department of Metabolic Biology Present address: Present address: UMR Qualisud Danièle Werck-Reichhart & Hugues Renault Laboratoire de Biométrie et Biologie Évolutive Max-Planck-Institute of Molecular Plant Physiology University of Strasbourg Institute for Advanced Study performed most of the experiments and contributed to molecular evolution analyses supervised by R.T. performed PAML and Fitmodel analyses and E.S.F Homology modelling and docking analyses were performed by F.A molecular characterization of Brassicaceae lineage II and III CYP98 members was performed by E.S.F and tests for flavonoid metabolism and site-directed mutagenesis were performed by H.R and performed data analysis and visualization designed the project and supervised the discussions The authors declare no competing financial interests Supplementary Tables 1-6 and Supplementary Note 1 (PDF 1832 kb) Download citation Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. MANSFIELD - The Blueberry Patch soon will open its new 15,000-square-foot building on the farm at 1285 W. Hanley Road, having outgrown its original greenhouse facility. The local business will close temporarily April 25 for two weeks except for the gift shop, which will remain open right up through the projected grand opening in mid-June. The soft opening is set for mid-May, after all the equipment from the kitchen, tables and chairs and merchandise are moved in and set up in the new building, which is within walking distance and just south of the original facility, according to The Blueberry Patch operators. "This will be a brief period where we will be moving and acclimating to our new home.... All this being said, now is the time to come and enjoy 'The Patch' as all of us know it now and have known it to be for the last 40 years," said Lisa Beilstein, who with her husband Steve are owners of The Blueberry Patch. Lisa Beilstein said the existing facility will eventually be replaced with a field of blueberries. Groundbreaking for the new facility was in May 2019, she said. Her husband and sons Andrew, Grant and Ben have done 90% of the work on the new building themselves and have incorporated some trees cut from the farm inside the new structure.  "We have enjoyed every memory we have made ... and we invite you to come and relive your own memories before it's too late," she said. "This will be a bittersweet time for us as we turn to the next chapter in our beloved family business." The family-operated business on Hanley Road started with blueberries but has continued to grow, offering all things blueberry — including blueberry plants in the greenhouse, blueberry doughnuts, blueberry wine, blueberry jam, blueberry pies in the freezer and more. The café, winery and restaurant will operate as one at the new place, Lisa said. Elsewhere, the Beilstein family continues to operate the Blue Barista Coffee Co. in the Richland Mall in Ontario. The Beilstein's son Andrew is the winemaker and coffee roaster. There is, of course, blueberry wine, with sweet, dry and reserved bottles on the wine list. Son Grant does all the field work and works in the winery too, his mother said. The Blueberry Patch offers 27 varieties of blueberries, with 27,000 bushes in the ground and 27 miles of irrigation, Steve said earlier. "And we have over 300,000 plants in the nursery." Lisa Beilstein said the family has done a lot of the construction work themselves under her husband's direction as he has an architectural background. The business also outgrew its parking and now there is plenty of parking to allow for even more events. "This has been a long, two-year journey filled with blood, sweat and tears — lots of laughs and smiles too, and the tears were mostly of joy," she said. "This has been something that our family has only dreamt about for years and it is finally coming to fruition," Lisa Beilstein said. "A huge part of making this dream come true is — our supporters, devout customers, dedicated employees, friends and the countless customers who have become dear friends and facets of our lives," she said. The Beilsteins built the original greenhouse, which for years has operated as the gift shop. Lisa reminisced that she had a playpen and a swing for the children when they were young behind the counter so she could run the greenhouse business. "I'm super proud of them (the kids). They were born and raised here," she said.  The busy woman said one day she and her husband will retire and they will continue to watch the "fruits of their labor grow." The new winery will hold up to 200 people, she said. There will also be an outdoor patio at the new site. "Everything is bigger and better," she said. Curtis, Beilstein Garner Big Ten Weekly Awards3/15/2010 12:00:00 AM | Women's Gymnastics Armstrong Williams takes on the news of the week and asks the questions you want answered. Don’t miss our weekly town hall. Beilstein Camper Sales fireby Nora Baldner 17 Dec 2010 18:06:06 GMT — A simple garden hose kept a mobile home fire from spreading at Beilstein Camper Sales in LaGrange Crews were working on the mobile home inside of a building on Beilstien property When a fire started toward the back of the mobile home and dragged the home outside to stop the fire from spreading LaGrange fire fighters were on the scene for about half an hour LaGrange Fire Chief Henry Gonsauls says the mobile home is destroyed Both Canton and Ewing fire departments were also called to the scene South Shore Elementary School third grade teacher Teresa Beilstein has been named a finalist for the 2019-2020 Maryland Teacher of the Year by the Maryland State Department of Education who was named Anne Arundel County Teacher of the Year in April The others are: Brandi Janson of Carroll County “I couldn’t be more excited and honored to move forward representing our awesome teachers,” said Beilstein who was surprised with the news in front of her third-grade class  by Superintendent George Arlotto “The excitement that our county generates is just so awesome and I can’t believe that I get to be the representative of so many amazing teachers who work so hard every day without the recognition.” Beilstein is the fifth consecutive county teacher and seventh in the last nine years to be named a state finalist Three AACPS teachers – Josh Carroll of South River High School in 2017-18 Linda Adamson of Mayo and Jessup elementary schools in 1993-94 and Patricia Neidhart of Broadneck High School in 1988-89 – have earned state Teacher of the Year honors Beilstein not only did her student teaching at South Shore but also has spent her entire seven-year career there She is known as a teacher who quickly builds relationships with colleagues as the most important ingredient to her healthy classroom but about myself,” a former student who is now thriving in middle school wrote in an endorsement letter that accompanied Beilstein’s nomination for Anne Arundel County Teacher of the Year Karen Salmon will announce Maryland’s Teacher of the Year at a banquet on October 25 Nominations for the 2019-2020 Anne Arundel County Teacher of the Year are now being accepted.  Please click here for more information 9 local Fall festivals you don’t want to miss Former State employee indicted on child pornography charges Eye On Annapolis is a community based site focusing strictly on Anne Arundel County These staff postings are general news postings made by our team of bloggers throughout the day and are not attributed to any one particular staff person Thank you for stopping by and hopefully for engaging with Eye On Annapolis with your comments and opinions both here and on our social channels There has never been a more critical time for community involvement than today–for any number of reasons Annapolis and Anne Arundel County are our homes and this site is about the quality of life we all share It is written for the local community by the local community BEAVER FALLS — Fifteen school marching bands will showcase their skills Saturday at the 41st annual Beaver County Invitational Marching Band Festival The event takes place from 6:30 to 9:30 p.m at Reeves Stadium on the Geneva College campus "This festival gives bands the opportunity to display their shows in a noncompetitive way to an audience that understands the hard work and dedication it takes to put together a successful halftime show," Jamie Beilstein director of the New Brighton High School band "Each band brings their own unique style and abilities to their performance and keeps audience members entertained throughout the evening." Tickets cost $8 at the gate or can be purchased for $6 in advance at the Brighton Music Center in New Brighton There will be T-shirts and programs for sale at the festival as well as candy and flower-grams to send to band students after their performances A DVD of the night’s performances also will be available to purchase along with bake sale items Along with the New Brighton Marching Lion Pride other marching bands that will perform their fall shows: Traveling from Huntingdon County to perform will be Southern Huntingdon High Beilstein said band and color guard students their directors and staff members put in numerous hours of rehearsal to learn music routines and drill formations for their 10-minute halftime shows "They begin working on their shows during the summer and continue to perfect their shows until the last game," Beilstein said once the foundation of the show is established more showy elements may be added to keep the show fresh and new to their audiences "One of the things I love most about this festival is how communities come together in order to show their support to the students and music education," Beilstein said "Students involved in the band are some of the best leaders in their schools and they sacrifice time from other activities to be involved respectful and disciplined than their peers who are not involved in music So this night not only celebrates their talents on the field but also their character off of the field." Last year's invitational drew 1,700 spectators BEAVER FALLS — Some people go to high school football games mainly to watch the marching bands They won't need to sit through any first downs or fumbles on Saturday when most of Beaver County's high school marching bands showcase their talents at Reeves Field on the Geneva College campus It's the 43rd annual Beaver County Invitational Marching Band Festival starting at 6:30 p.m. The event will feature 12 local high school marching bands representing Beaver The Geneva College band will entertain on its Beaver Falls turf Over 1,800 people attended last year's invitational which once again is hosted by the New Brighton Marching Lion Pride the Beaver County Invitational Marching Band Festival gives the bands a chance to perform their regular halftime shows for peers fans and appreciative new audience members.  Candy and flower-grams also will be available to send to band students after their performances A DVD of the night’s performances will be available to order The invitational's tickets cost $9 at the gate or $7 in advance at the Brighton Music Center in downtown New Brighton "Please come out and support this event and take the time to watch all the students strut their stuff in their halftime shows," Jamie Beilstein "They along with the music department staff all put in a great amount of time and energy to make these shows a success." Beilstein said the marching band festival is a great opportunity for the community to gather to support music education in the county and is also an experience cherished by the students this event is the highlight of the marching band season," Beilstein said. "They love to perform in front of a crowd who truly understands the amount of hard work talent and dedication it takes to put together a successful halftime show." the invitational's band directors include Beaver Matthew Diehl; Western Beaver, Andrea Capehart; and Ellwood City Aliquippa High didn't field a marching band this season though alumni and community members are filling in at Quips football games Aliquippa alumni band fills in: Aliquippa alumni & community fill in as band for Quips football games Ambridge High's band will not attend the event because it's the same night as their Homecoming Dance Beaver County radio news: WBVP-WMBA sold to St. Barnabas Broadcasting Scott Tady is the local Entertainment Reporter for The Beaver County Times and Ellwood City Ledger