2025 (GLOBE NEWSWIRE) -- Lowey Dannenberg P.C. a preeminent law firm in obtaining redress for consumers and investors announces the filing of a class action lawsuit against BigBear.ai Holdings (“BigBear” or the “Company”) (NYSE: BBAI) for violations of the federal securities laws on behalf of investors who purchased or acquired BigBear common stock between March 31 a complaint was filed against the Company and certain of its current and former officers Defendants made false and/or misleading statements and/or failed to disclose that: (i) BigBear maintained deficient accounting review policies related to the reporting and disclosure of certain non-routine the Company incorrectly determined that the conversion option within the 2026 Convertible Notes qualified for the derivative scope exception under ASC 815-40 and failed to bifurcate the conversion option as required by ASC 815-15; (iii) accordingly BigBear had improperly accounted for the 2026 Convertible Notes; (iv) the foregoing error caused BigBear to misstate various items in several of the Company’s previously issued financial statements; (v) as a result these financial statements were inaccurate and would likely need to be restated; (vi) BigBear would require extra time and expense to correct the inaccurate financial statements thereby increasing the risk that the Company would be unable to timely file certain financial reports with the SEC; and (vii) as a result the Company’s public statements were materially false and misleading at all relevant times BigBear’s common stock declined precipitously If you suffered a loss of more than $50,000 in BigBear’s securities, and wish to participate, or learn more, click here please contact our attorneys at (914) 733-7256 or via email to Andrea Farah (afarah@lowey.com) or Vincent R Any investor who wishes to serve as Lead Plaintiff must act before June 10 Lowey Dannenberg is a national firm representing institutional and individual investors who suffered financial losses resulting from corporate fraud and malfeasance in violation of federal securities and antitrust laws The firm has significant experience in prosecuting multi-million-dollar lawsuits and has recovered billions of dollars on behalf of its clients NY 10601Tel: (914) 733-7234Email: afarah@lowey.com An official website of the United States government The .gov means it’s official.Federal government websites often end in .gov or .mil make sure you're on a federal government site The https:// ensures that you're connecting to the official website and that any information you provide is encrypted and sent securely Director Walt Dannenberg has led VA Long Beach Healthcare System (VALBHS) as Chief Executive Officer and Medical Center Director since February 2017 With the goal of becoming the #1 healthcare system in the nation Dannenberg and VALBHS have embarked on a transformational journey that strives for service excellence This includes overseeing active construction projects to bring state-of-the-art facilities to VALBHS and expanding virtual care modalities so that Veterans can access their care online from anywhere in the world “There is no better mission than to serve those who have served” and “that’s why our Veterans deserve nothing but the best.” Dannenberg served as VA Palo Alto Heath Care System’s Associate Director and as Assistant Director with the VA Puget Sound Health Care System Dannenberg began his VA career as a Graduate Healthcare Administrative Fellow in 2006 at the Central Arkansas Veterans Healthcare System in Little Rock He is a Fellow of the American College of Health Care Executives (FACHE) and previously served as Vice-President of the South Texas Chapter of the American College of Health Care Executives He holds an undergraduate degree in chemistry from Texas A&M University as well as a master’s degree in Healthcare Administration and Business Administration from the University of Houston - Clear Lake Dannenberg is a member of the 2016 Class of Leadership VA and a graduate of VHA’s 2010 Health Care Leadership Development Program Dannenberg is the Acting Director of Hampton VA Healthcare System NEW YORK, April 15, 2025 (GLOBE NEWSWIRE) -- Lowey Dannenberg, P.C.’s Data Privacy Team is investigating claims that data brokers and identity solution providers may be profiling consumers without consent or meaningful disclosures Many consumers are unaware that certain data brokers and identity solution providers quietly track them across their computers Some of these companies use this data to create hyper-specific identity profiles used to facilitate targeted advertising without consumers’ knowledge or consent Lowey’s Data Privacy Team is currently investigating companies engaged in these types of practices. You can find more information about this investigation here has filed lawsuits against three companies alleging they created or used consumer identity profiles without consent: is a national class action law firm with offices in New York and Pennsylvania Lowey Dannenberg attorneys routinely litigate complex data breach and privacy class actions This press release may be considered Attorney Advertising in some jurisdictions announces the filing of a class action lawsuit against Quantum Computing Inc (“QCI” or the “Company”) (NASDAQ: QUBT) for violations of the federal securities laws on behalf of investors who purchased or acquired QCI common stock between March 30 Defendants made false and/or misleading statements and/or failed to disclose that: (i) Defendants overstated the capabilities of QCI’s quantum computing technologies and/or services; (ii) Defendants overstated the scope and nature of QCI’s relationship with NASA as well as the scope and nature of QCI’s NASA-related contracts and/or subcontracts; (iii) Defendants overstated QCI’s progress in developing a TFLN foundry and orders for the Company’s TFLN chips; (iv) QCI’s business dealings with Quad M and millionways both qualified as related party transactions; (v) accordingly on undisclosed related party transactions; (vi) all the foregoing was likely to have a significant negative impact on QCI’s business and reputation; and (vii) as a result Defendants’ public statements were materially false and misleading at all relevant times Any investor who wishes to serve as Lead Plaintiff must act before April 28 Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: afarah@lowey.com announces the filing of a class action lawsuit against Edison International (“Edison” or the “Company”) (NYSE: EIX) for violations of the federal securities laws on behalf of investors who purchased or acquired Edison common stock between February 25 a complaint was filed against the Company and certain of its officers Defendants made false and/or misleading statements and/or failed to disclose that: (1) Edison’s claim that Southern California Edison Company used its Public Safety Power Shutoffs program to “proactively de-energize power lines to mitigate the risk of catastrophic wildfires during extreme weather events” was false; (2) this resulted in heightened fire risk in California and heightened legal exposure to the Company; and (3) as a result Defendants’ statements about Edison’s business were materially false and misleading and/or lacked a reasonable basis at all times Edison’s common stock declined precipitously If you suffered a loss of more than $200,000 in Edison’s securities, and wish to participate, or learn more, click here or please contact our attorneys at (914) 733-7256 or via email to Andrea Farah (afarah@lowey.com) or Vincent R Any investor who wishes to serve as Lead Plaintiff must act before April 21 Brandeis combines the resources of a world-class research university with the personal attention of a liberal arts setting The Graduate School of Arts and Sciences offers 17 doctoral programs and more than 40 master's and postbaccalaureate programs One of the key differences at the Graduate School of Arts and Sciences is our emphasis on interdisciplinary learning You will learn the importance of connecting with people who have a broad range of expertise and experience We support all doctoral students and the majority of master’s and post-baccalaureate students who maintain satisfactory academic progress with loans and scholarships Keep up to date with the latest news and events from the Graduate School of Arts and Sciences Find important resources and information to help you succeed as a GSAS student Find a member of staff who can address your questions Meet your Graduate Department Representative and your Director of Graduate Study Abigail Arnold | Graduate School of Arts and Sciences Jorah Dannenberg is the newest faculty member in Brandeis University’s Department of Philosophy His work focuses on the area of moral philosophy He spoke to the Graduate School of Arts and Sciences about what he studies and why it matters arriving in Massachusetts after a lifetime in California I was born and raised in California and studied at Pomona College as an undergraduate and UCLA as a graduate student I then worked at Stanford University for just over twelve years as a postdoc and then a faculty member I’m something of a unicorn in academia in that I’ve spent my entire life up until now in California I knew that Brandeis had a fantastic reputation for having a small but really excellent Philosophy department I knew one current faculty member personally and several by reputation and I had also met several former Brandeis MA students (including one who went on to the PhD program at Stanford) How did you become interested in moral philosophy I fell in love with philosophy as an undergraduate I experienced lots of ups and downs - lots of changes I didn’t feel so at home in what I was doing as a student but the exception to that feeling was always philosophy I got to think about the questions I was going to stay up at night thinking about anyway reading from great texts and learning from philosophy professors who always encouraged me to dispute the answers being offered if I didn’t agree or wasn’t convinced and I’ve always found a wide array of topics fascinating But my attention is always drawn back to issues in ethics and politics My own research is divided (roughly) into three clusters The first of these I’d call “the ethics of communication and commitment.” Here I’m especially interested in these topics when they require bringing together different parts of philosophy are interesting to philosophers of language I often get interested in a topic because I think there’s a really hard ethical question and nobody else’s answers really satisfy me though at first I’m not exactly sure why Philosophy is kind of about trying to figure out why something is bothering you – it’s a field that’s a good fit for people like me who are sometimes irritated by things and can’t let go of them There’s a second cluster of my research where I try to address more abstract questions about the relationship between our rational and emotional sides The debates on this topic beginning in the Enlightenment era really animate me Should we aspire to live the life of reason Or do we live better by relating to our reason as a very helpful tool but not in itself the key to living a good life I find myself on the side of people who say the latter But that kind of answer can be hard to defend nowadays in moral philosophy; I think the field has a prejudice in favor of more “rationalistic” answers in ethics where I’m thinking more about philosophical methodology: what is it about how we do moral and political philosophy nowadays that makes it harder to defend the less rationalistic approach how might biases of all sorts be built into the way we ask questions in moral philosophy What makes your research important to society I was chairing a conference session and introducing myself to a philosopher I hadn’t met before He asked what I worked on and I said I was working on something about the importance of truth telling and lies and deception So it’s a historical project!” I think the importance of moral and political philosophy should always be pretty evident - whenever it’s not clear why it matters to society that’s a sign that we aren’t doing our job all that well (which certainly can happen) Here’s just one example: questions about why it’s important for us to be able to trust one another but also about why it can be so difficult to do so strike me as pretty clearly important right now What do you think are the strengths of Brandeis's grad program in Philosophy What are you looking forward to about teaching here this semester Brandeis’s master’s program has a very strong reputation as one of a handful of places where students who are interested in going on to a PhD receive excellent preparation I’ve served on a few PhD admissions committees over the years and they are always looking to see that people will thrive I also have the sense that Brandeis does a good job of trying to strike the right balance between introducing students to the professionalization that’s necessary for thriving in academic philosophy (things like publishing articles and attending conferences) but also letting students swim in the subject so that they can fall in love with it… and out of love with it… and back in love again I think those of us who are academic philosophers often have a constrained view of what you can do with a philosophy degree but the department here is also thinking about other things people can do and ways they can benefit from the degree I am teaching a mixed graduate and undergraduate course on truth and trust this semester I am looking forward to meeting my fifteen or so students and spending the next semester talking with them about these really interesting questions teaching moral philosophy is more about trying to puzzle through questions that no one has any more inherent authority to answer than anyone else I’m looking forward to seeing where they want to go with the material I will loosely organize the course around a series of puzzles that arise in this area Trust involves making yourself vulnerable to another – someone can harm you more when they betray your trust But it is something we actively seek out in our lives and wouldn’t want to live without even though we’re much more vulnerable What else would you like to share as a new member of the Brandeis community From every experience I’ve had at Brandeis thus far - from my very first Zoom interview with my now colleagues onward - the sense of genuine community here has been manifest Brandeis feels to me like a place that people really want to be a part of and I’m excited to get to know Brandeis and everyone here in the coming years Brandeis University's Graduate School of Arts and Sciences (GSAS) is one of four graduate schools on campus and is situated within an exciting multifaceted research university for scholarship just outside the educational hub of Boston announces the filing of a class action lawsuit against Venture Global (“Venture Global” or the “Company”) (NYSE: VG) for violations of the federal securities laws on behalf of investors who purchased or acquired Venture Global common stock at the time of the Company’s Initial Public Offering (“IPO”) on January 24 certain of its current officers and directors Defendants made false and/or misleading statements and/or failed to disclose that: (1) Venture Global’s ability to deliver liquefied natural gas (LNG) to the world and to continue development of its five natural gas liquefication and export projects depended on customer contracts; (2) Venture Global was facing legal challenges from existing large clients due to delays in supply contracts as it commissioned its projects; and (3) accordingly Venture Global’s business and/or financial prospects were overstated Venture Global’s common stock declined precipitously Any investor who wishes to serve as Lead Plaintiff must act before April 18 About Lowey DannenbergLowey Dannenberg is a national firm representing institutional and individual investors Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: afarah@lowey.com  2024 (GLOBE NEWSWIRE) -- Lowey Dannenberg P.C. announces the filing of a class action lawsuit against Dentsply Sirona Inc (“Dentsply Sirona,” “Dentsply,” or the “Company”) (NASDAQ: XRAY) for violations of the federal securities laws on behalf of investors who purchased or acquired Dentsply Sirona common stock between December 1 Defendants made false and/or misleading statements and/or failed to disclose that: (1) Dentsply targeted low-income people who did not have access to good oral hygiene education which often meant patients signing up for Byte had underlying dental issues that would have made them ineligible for treatment; (2) the push for Byte growth and sales commissions caused sales employees to sell to contraindicated patients; (3) as a result of the above the Byte patient onboarding workflow did not provide adequate assurance that contraindicated patients did not enter treatment; (4) before and during the Class Period reports of Byte patient injuries were pouring in; (5) Dentsply knew that its Byte aligners were causing severe patient injuries for years but did little to investigate those injuries or notify the U.S Food and Drug Administration (“FDA”); (6) Dentsply had no systems in place to notify the FDA of these injuries which the Company is required to do within 30 days of learning of a problem; (7) the FDA had received a sharp uptick in reports of serious injuries from Byte patients; (8) as a result of the above Dentsply materially overstated the goodwill value of Byte; (9) as a result of the above Defendants’ positive statements about the Company’s business and prospects were materially false and misleading and/or lacked a reasonable basis at all relevant times Dentsply Sirona’s common stock declined precipitously If you suffered a loss of more than $100,000 in Dentsply Sirona’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before January 27 Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: investigations@lowey.com  Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors Walt Dannenberg stepped down as executive director of the Hampton VA Medical Center Simmons was reassigned after a series of blistering VA Inspector General's reports called into question the quality of care at the local hospital system Hampton’s Director of Operations Michael Harper will run the Hampton VA until a new director is appointed according to a spokesman for the Hampton VA Dannenberg said he leaned on Harper as a subject matter expert Dannenberg’s departure comes as the VA has abruptly fired staff including at Hampton and looks to cut at least an additional 70,000 jobs nationwide The Hampton VA system is one of the fastest- growing VA systems in the country “We're doing everything in our power to limit how that affects the care we deliver and make sure that we're still delivering time to care for all the veterans The independent inspector general for the VA criticized the hospital system in a series of reports stretching back to 2022 the national VA removed the leadership at Hampton after a report concluded the top officials seemed unaware of how to properly discipline staff in its surgical unit “There were clearly multiple layers of leadership failures in responding to many of the concerns that initially started the work and that's really what the report is about,” said Dr principal deputy assistant inspector general for healthcare inspections were reassigned to Veteran Integrated Health Services Network 6 which is the regional VA network serving the Mid-Atlantic region Get local news every weekday in your inbox Sign-up here. This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page announces the filing of a class action lawsuit against Integral Ad Science Holding Corp (“IAS” or the “Company”) (NASDAQ: IAS) for violations of the federal securities laws on behalf of investors who purchased or acquired IAS common stock between March 2 Defendants made false and/or misleading statements and/or failed to disclose that: (i) that IAS was experiencing a new material trend of increased competitive pricing pressures and that the IAS’s public statements were materially false and misleading at all relevant times If you suffered a loss of more than $300,000 in IAS’ securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before March 31 We have the address for the funeral home & the family on file If you're not happy with your card we'll send a replacement or refund your money Dreyer created this Life Tributes page to make it easy to share your memories © 2025 Langeland-Sterenberg Yntema Funeral Homes Made with love by funeralOne announces the filing of a class action lawsuit against PACS Group or the “Company”) (NYSE: PACS) for violations of the federal securities laws on behalf of investors who purchased or acquired PACS Group common stock: (a) at the time of the Company’s Initial Public Offering (“IPO”) on April 11 Defendants made false and/or misleading statements and/or failed to disclose that: (1) that the Company engaged in a “scheme” to submit false Medicare claims which “drove more than 100% of PACS’ operating and net income from 2020 – 2023”; (2) that the Company engaged in a “scheme” to “bill thousands of unnecessary respiratory and sensory integration therapies to Medicare”; (3) that the Company engaged in a scheme to falsify documentation related to licensure and staffing; and (4) that and prospects were materially misleading and/or lacked a reasonable basis PACS Group’s common stock declined precipitously Any investor who wishes to serve as Lead Plaintiff must act before January 13 Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: investigations@lowey.com  announces the filing of a class action lawsuit against TransMedics Group (“TransMedics” or the “Company”) (NASDAQ: TMDX) for violations of the federal securities laws on behalf of investors who purchased or acquired TransMedics common stock between February 28 Defendants made false and/or misleading statements and/or failed to disclose that: (i) TransMedics used kickbacks and coercive tactics to generate business and revenue; (ii) TransMedics engaged in unsafe practices and hid safety issues and generally lacked safety oversight; and (iii) the foregoing subjected TransMedics to heightened risk of scrutiny and regulatory risk TransMedics’ common stock declined precipitously If you suffered a loss of more than $100,000 in TransMedics’ securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before April 15 announces the filing of a class action lawsuit against AppLovin Corporation (“AppLovin” or the “Company”) (NASDAQ: APP) for violations of the federal securities laws on behalf of investors who purchased or acquired AppLovin common stock between May 10 Defendants created the false impression that AppLovin’s enhanced AXON 2.0 digital ad platform in addition to its “cutting-edge AI technologies,” would more efficiently match advertisements to mobile games in addition to expanding into web-based marketing and e-commerce AppLovin was exploiting advertising data from Meta Platforms and using manipulative practices that forced unwanted apps on customers via a “backdoor installation scheme” which inaccurately inflated installation numbers AppLovin’s common stock declined precipitously If you suffered a loss of more than $200,000 in AppLovin’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before May 5 announces the filing of a class action lawsuit against Novo Nordisk A/S (“Novo” or the “Company”) (NYSE: NVO) for violations of the federal securities laws on behalf of investors who purchased or acquired Novo common stock between November 2 Defendants made false and/or misleading statements and/or failed to disclose that: (i) defendants created the false impression that they possessed reliable information pertaining to Novo’s projected successful outcome of Novo’s phase 3 CagriSema study on obesity named “REDEFINE-1,” while avoiding discussions centered around dosage tolerability; (ii) Novo’s repeated optimistic claims that CagriSema would achieve at least 25% weight loss in the REDEFINE-1 study fell short of reality; and (iii) the utilization of the “flexible protocol” limited the study’s ability to effectively provide weight loss data on the dosage tested suggesting either that tolerability was significantly worse than anticipated resulting in patients titrating down their dosages to avoid complications or that the patient selection process was rushed leading to the onboarding of patients that did not desire to even achieve the 25% weight loss Novo sought to demonstrate Novo’s common stock declined precipitously Any investor who wishes to serve as Lead Plaintiff must act before March 25 Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: afarah@lowey.com  Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: afarah@lowey.com  If you suffered a loss of more than $300,000 in IAS’ securities, and wish to participate, or learn more, click here announces the filing of a class action lawsuit against AstraZeneca PLC (“AstraZeneca” or the “Company”) (NASDAQ: AZN) for violations of the federal securities laws on behalf of investors who purchased or acquired AstraZeneca common stock between February 23 Defendants made false and/or misleading statements and/or failed to disclose that: (1) AstraZeneca engaged in insurance fraud in China; (2) as a result AstraZeneca faced heightened legal exposure in China which eventually resulted in the AstraZeneca China President being detained by Chinese law enforcement authorities; (3) as a result AstraZeneca understated its legal risks; (4) the foregoing could materially harm AstraZeneca’s business activities in China; and (5) as a result were materially false and misleading and/or lacked a reasonable basis at all relevant times AstraZeneca’s common stock declined precipitously If you suffered a loss of more than $200,000 in AstraZeneca’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before February 21 Contact:Lowey Dannenberg P.C.44 South Broadway NY 10601Tel: (914) 733-7234Email: afarah@lowey.com announces the filing of a class action lawsuit against Five9 (“Five9” or the “Company”) (NASDAQ: FIVN) for violations of the federal securities laws on behalf of investors who purchased or acquired Five9 common stock between June 4 Defendants made false and/or misleading statements and/or failed to disclose that: (i) Five9’s net new business was not “strong irrespective of the macro” and was hampered by macroeconomic issues such as constrained and scrutinized customer budgets; (ii) Five9 was in the midst of a challenging bookings quarter due and the Company was not “seeing very strong bookings momentum”; and (iii) Defendants did not have “enough information in terms of [their] existing customers that are going live” such that the statements that Five9 would see a positive inflection in its dollar-based retention rate lacked a reasonable basis Five9’s common stock declined precipitously If you suffered a loss of more than $200,000 in Five9’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before February 3 announces the filing of a class action lawsuit against ZoomInfo Technologies (“ZoomInfo” or the “Company”) (NASDAQ: ZI) for violations of the federal securities laws on behalf of investors who purchased or acquired ZoomInfo common stock between November 10 a complaint was filed against the Company and certain of its officers and directors alleging that throughout the Class Period Defendants made false and/or misleading statements and/or failed to disclose that: (a) that ZoomInfo’s financial and operational results during the Class Period had been temporarily inflated by the ephemeral effects of the COVID-19 pandemic and created a hidden demand cliff for costumer contract renewals in future periods; and (e) that as a result and customer and retention metrics were materially overstated ZoomInfo’s common stock declined precipitously If you suffered a loss of more than $100,000 in ZoomInfo’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before November 4 NY 10601Tel: (914) 733-7234Email: investigations@lowey.com announces the filing of a class action lawsuit against Zeta Global Holdings Corp (“Zeta” or the “Company”) (NYSE: ZETA) for violations of the federal securities laws on behalf of investors who purchased or acquired Zeta common stock between February 27 a complaint was filed against the Company and certain of its current officers Defendants made false and/or misleading statements and/or failed to disclose that: (1) that Zeta used two-way contracts to artificially inflate financial results; (2) that Zeta engaged in round trip transactions to artificially inflate financial results; (3) that Zeta utilized predatory consent farms to collect user data; (4) that these consent farms have driven almost the entirety of Zeta’s growth; and (5) that Zeta’s common stock declined precipitously If you suffered a loss of more than $100,000 in Zeta’s securities, and wish to participate, or learn more, click here Any investor who wishes to serve as Lead Plaintiff must act before January 21 Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: investigations@lowey.com   HARWICH – There is an historic level of financial aid available in Massachusetts to help every student seek a higher education Patrick Tutwiler told members of the Junior Class at Monomoy Regional High School on Monday The high school was one of eight stops planned throughout the state on Tutwiler’s Higher Education Aid Road Show set up to expand student awareness of federal and state funding available for post-secondary educational opportunities Monday’s Monomoy High event was the only one scheduled on the Cape.“My highest role here is creating the conditions for people to realize their dream,” Tutwiler told students “My responsibility is to make sure every student is prepared for the next step.”   Finances can be a major deterrent for students seeking to attend college but the message from Tutwiler and Deputy Commissioner of Education Michael Dannenberg was that funding is available and state officials are working to make it easier to access Tutwiler said his department has been working on simplifying access to state and federal student aid He encouraged students to complete the Free Application for Federal Student Aid (FAFSA) and apply for the nearly $400 million available in state financial aid the Healey-Driscoll Administration and the state legislature have more than doubled state financial aid launching one of the most comprehensive free community college programs in the country and making public universities tuition– and fee-free for Pell Grant-eligible students  The state funding includes $80 million for MASSGRANT Plus for eligible community college students; $118 million for free community college; and $28.67 million for Student Success funding for students at community colleges and universities When asked about the prognosis for continued federal education funding Tutwiler said he probably is not the right person to answer that question adding that he has listened to Linda McMahon’s confirmation testimony for federal secretary of education and she supports Pell Grants Tutwiler’s road trip is about increasing awareness of the availability of grant programs Only 51 percent of Massachusetts high school graduates access funding through the FAFSA; the national average is even less at 46 percent Many more students should be accessing the money Dannenberg said each of the state’s nine public universities are free for families earning less than $85,000 Tutwiler said 25 percent of Monomoy Regional High School graduates last year went on to community colleges Monomoy Regional High School guidance counselor Sean Burke said his daughter attends Cape Cod Community College One of the problems there is that classes are filling up so fast that it can be difficult to get into courses “We’re celebrating 10,000 new students because financial barriers aren’t there.”     He added “Higher education is about opportunity and socio-economic upward mobility breaking intergenerational cycles of poverty Post-secondary education not only leads students to fulfilling and rewarding careers but it also helps build a talented  workforce and improve the overall economy.”  Dannenberg said a person with a college degree can earn $1.2 million more over a lifetime than someone without a degree   Tutwiler wanted to know how to better educate students and parents about the availability of the funds He asked students about ways to further disseminate information on the availability of these grants.MRHS Junior Natalie Sims said there should be guidance meetings focusing on the information   Junior Isabelle Long said better communication is needed Students said they get much of their information from social media and there are no postings about the information  “Social media is a huge thing in this world,” another student said “We need to be better on social media,” agreed Tutwiler.Rea Christakis said there needs to be better communication with parents on the availability of financial aid  “You as students also have to serve as ambassadors to your classmates,” Tutwiler said of disseminating grant opportunities.Tutwiler said that 92 percent of the students who complete the FAFSA student aid application go on to college He urged students to also visit Mass.gov/Student Aid to learn more about free and affordable college opportunities (“TransMedics”) (NASDAQ:TMDX) for potential violations of the federal securities laws The firm has significant experience in prosecuting multi-million-dollar lawsuits and has previously recovered billions of dollars on behalf of investors Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7256Email:  investigations@lowey.com  HARWICH —Two Massachusetts state education officials went on the road Monday to tell Monomoy Regional High School juniors about opportunities for free and affordable college throughout the state The event, with about 30 students, was one of eight stops on the Higher Education Financial Aid Road Show across the state to encourage students to complete the free application for Federal Student Aid (FAFSA) and apply for the nearly $400 million available The high school in Harwich is the only Cape town to be part of the campaign underway throughout the state in February and March Deputy Commissioner of Higher Education Michael Dannenberg who joined Massachusetts Education Secretary Patrick Tutwiler for the first time at one of the events told the students that financial aid for state colleges has doubled in the past two years “It means that anyone who is a high school graduate can go to any community college tuition free,” Dannenberg said Every state university is also free to families whose incomes are less than $85,000 and more money is available for housing and other expenses “There’s a problem.” The problem is that despite 51% of students in the state applying for the financial aid last year He asked the students for their help and suggestions in getting the word out about the financial options Isabelle Long was the first student to speak up “You need to communicate more.” She said the financial aid information is not posted anywhere in the school or in one common place Other students' suggestions included posting signs at schools and using QR codes since they said students "don’t watch the news like their grandmothers." The students said there should be more communication to families about the financial aid opportunities “We need to be better on social media," he said He also said "families overestimate the cost of college and underestimate student aid." The process for filling out the free financial aid form should only take an hour initially and then 20 minutes on return visits to the site He said filling out the federal form automatically goes to the state and can be used for applying for up to 20 colleges Tutwiler noted that 92% of those who fill out the financial aid form go on to college He described the “value proposition” of higher education “We know that a college degree is the most significant factor in social mobility It will unlock more doors and barriers,” Tutwiler said He added that people with college degrees earn $1 million more in a lifetime than those without one Dannenberg said a degree is also about security since 70% of all jobs are going to require college “Higher education gives you options,” he told the students The state Department of Education is continuing more promotions of the financial aid. Students can learn more about state financial aid by visiting Mass.gov/StudentAid The financial aid push is tied in with Gov. Maura Healey's fiscal year 2026 budget, which includes $80 million for MASSGrant Plus, $118 million for free community college and $28.67 million for SUCCESS funding at public community colleges and universities The Healey-Driscoll Administration also filed a $2.5 billion bill in January to modernize public higher education campuses in Massachusetts the largest such improvements in decades for the University of Massachusetts system Susan Vaughn writes about transportation and other local community issues affecting Cape Cod residents and visitors. She can be reached at smharris@gannett.com Thanks to our subscribers, who help make this coverage possible. If you are not a subscriber, please consider supporting quality local journalism with a Cape Cod Times subscription. Here are our subscription plans. announces the filing of a class action lawsuit against iLearningEngines (“iLearningEngines” or the “Company”) (NASDAQ: AILE) for violations of the federal securities laws on behalf of investors who purchased or acquired iLearningEngines common stock between April 22 Defendants made false and/or misleading statements and/or failed to disclose that: (1) that the Company’s “Technology Partner” was an undisclosed related party; (2) that the Company used its undisclosed related party Technology Partner to report “largely fake” revenue and expenses; (3) that the Company significantly overstated its revenue; and (4) that iLearningEngines’ common stock declined precipitously If you suffered a loss of more than $50,000 in iLearningEngines’ securities Any investor who wishes to serve as Lead Plaintiff must act before December 6 Contact:Lowey Dannenberg P.C.44 South Broadway, Suite 1100White Plains, NY 10601Tel: (914) 733-7234Email: investigations@lowey.com Enter your phone number above to have directions sent via text Volume 16 - 2022 | https://doi.org/10.3389/fncir.2022.957441 This article is part of the Research TopicThe Medial Septum as a Smart Clock: New Aspects of its Function Beyond PacemakingView all 8 articles Cholinergic projection neurons in the medial septum and diagonal band of Broca are the major source of cholinergic modulation of hippocampal circuit functions that support neural coding of location and running speed Changes in cholinergic modulation are known to correlate with changes in brain states whether cholinergic modulation can change fast enough to serve as a potential speed signal in hippocampal and parahippocampal cortices and whether the temporal dynamics in such a signal depend on the presence of visual cues remain unknown we use a fiber-photometric approach to quantify the temporal dynamics of cholinergic activity in freely moving mice as a function of the animal’s movement speed and visual cues We show that the population activity of cholinergic neurons in the medial septum and diagonal band of Broca changes fast enough to be aligned well with changes in the animal’s running speed and is strongly and linearly correlated to the logarithm of the animal’s running speed the cholinergic modulation remains strongly and linearly correlated to the speed of the animal’s neck movements during periods of stationary activity we show that cholinergic modulation is unaltered during darkness a stereotypic behavior where the mouse stands on its hindlimbs to scan the environment from an elevated perspective is associated with higher cholinergic activity than expected from neck movements on the horizontal plane alone these data show that temporal dynamics in the cholinergic modulation of hippocampal circuits are fast enough to provide a potential running speed signal in real-time the data show that cholinergic modulation is primarily a function of the logarithm of the animal’s movement speed both during locomotion and during stationary activity with no significant interaction with visual inputs These data advance our understanding of temporal dynamics in cholinergic modulation of hippocampal circuits and their functions in the context of neural coding of location and running speed We next tested whether the activity of the septo-hippocampal cholinergic system is a function of characteristic behaviors including stationary activities such as grooming and rearing we analyzed whether the observed temporal dynamics in cholinergic activity were a function of visual cues The presented results demonstrate that the activity of the septo-hippocampal cholinergic system (i) changes fast enough to match changes in running speed (ii) is strongly and linearly correlated to the logarithm of the animal’s running speed (iii) remains strongly correlated to the animal’s neck movements during stationary activity mice were habituated to the experimenter and testing room over at least 1 week by handling mice at least once daily inside the testing room mice were gently removed repeatedly from their home cage and held in the experimenter’s hand All experimental procedures were approved by the Institutional Animal Care and Use Committee for the Charles River Campus at Boston University Mice were purchased from The Jackson Laboratory (Wildtype Transgenic mice were maintained as homozygous and heterozygous mice of both sexes were used for experiments adult mice were housed in Plexiglas cages together with their siblings prior to surgery but separated for individual housing after surgery and maintained on a reversed 12-h light/12-h dark cycle The housing cages contained a spherical treadmill that provided mice the opportunity to exercise WPI) was left in place for 3 and 5 min after the first and second injections (100-nl/min WPI) to prevent backflow of the injected virus solution the same opening in the skull was used to implant an implantable optical fiber (total diameter: 230-μm; 200-μm core 0.48; MFC_200/230-0.48_8mm_SMR_FLT; Doric lenses) 1.2-mm anterior and 0.7-mm lateral to Bregma The optical fiber was lowered 4.2-mm from the brain surface at an 10° polar and -90° azimuth angle and cemented on the animal’s skull with dental acrylic that was blackened by mixing in graphite Animals were given buprenorphine (0.1-mg/kg i.p.) during a 5-day postsurgical care period and allowed 1 week in total to fully recover after surgery before beginning of recordings All recordings were performed while animals foraged for small pieces of Froot Loops (Kellog Company United States) in the open-field environment The fiber photometry experiments were performed within a time window of ∼1–3 weeks after the virus injection levels of jGCaMP7s expression where high enough to result in a good signal-to-noise ratio but low enough for cell toxicity to occur A typical recording session lasted between 5 and 15-min A rectangular housing cage (34-cm × 28-cm) with transparent 20-cm high walls (n = 1 mouse) or an acrylic box (40-cm × 40-cm) with black 30-cm high walls and a visual cue card (n = 4 mice) were used as open field environments The recording room contained no windows and was shielded with a laser-proof black curtain Recording sessions of the one mouse foraging in the rectangular housing cage were performed during standard lighting conditions only Recordings of the four other mice foraging in the acrylic box were performed during standard lighting conditions and darkness The first and last sessions were performed during standard room lighting with the room ceiling light turned on and the second and third sessions were recorded during darkness with the room ceiling light turned off The experimental arena was cleaned with 70% isopropanol followed by water between sessions and mice Animals of both sexes were included in this study The phase of estrous cycle was not checked in female mice before experiments animals were deeply anesthetized by intraperitoneal injection of Euthasol (390 mg/kg) and transcardial perfusion was performed with Dulbecco’s phosphate buffered saline (DPBS) containing 0.9% calcium chloride followed by 10% buffered formalin (SF100-4 Brains were extracted and stored in fixative for 1 day The MSDB was cut into 35-μm coronal sections using a vibratome the tissue was submerged in DPBS containing 0.9% calcium chloride For immunolabeling of ChAT in MSDB neurons slices were incubated for 2 days at 4 degrees Celsius in wells of a 48-well plate with goat anti-ChAT affinity purified polyclonal antibody (catalog #AB 144P diluted 1:200) and 0.3% Triton X-100 (Sigma-Aldrich washed three times for 15-min with DPBS containing 0.9% calcium chloride at room temperature and incubated for 2 h at room temperature with a secondary antibody (Cy3-conjugated donkey anti-goat IgG polyclonal antibody Slices were washed three times again and mounted in Aqua-Poly/Mount (#18606-20 We used a custom-built fiber photometry system inspired by Gunaydin et al. (2014) and Lerner et al. (2015) The fiber photometry system used a 473-nm Omnicron Luxx laser modulated at 211-Hz and a 405-nm UV LED (Thorlabs M405FP1) modulated at 531-Hz using optical choppers Excitation at 405-nm served as an isosbestic control signal Laser light was delivered into the brain via a system of fiber patch cords (Thorlabs) and a rotary joint (FRJ_1x1_FC-FC The laser light power entering the implanted optical fiber was measured before and after every recording session and adjusted before the recording session to yield an estimate of 40–60 μW laser power delivered into the MSDB Data were acquired at a sampling rate of 500-Hz Mice were video-tracked using a thermal camera (FLIR SC8000) at a video frame rate of 26–30 frames/s controlled via TTL pulses generated by an external signal generator Temperature values were color-coded with a gray scale and exported in mpeg-4 video format TTL pulses sent from the camera were recorded along with the fiber-photometry system to synchronize the videos with the fiber-photometry signal care was taken that camera settings remained constant (same position over the open field environment Data from these three mice were used for VAME analysis We then formulated an optimization problem to find the two parameters a and b that minimized the term ∑(s − (c*α + β))2 and c stands for the adjusted control signal we computed DF/F as s-(c*α+β)c*α+β For analyses that average or compare data across sessions the z-scored ΔF/F was used to account for variations in signal strength across sessions The z-scored ΔF/F was computed as (x-x¯)sx and sx for the standard deviation of ΔF/F over time We used the deep learning tool DeepLabCut (Mathis et al., 2018) for markerless pose estimation of the animal’s neck The neck position was used to estimate the animal’s movement speed For later identification of behavioral motifs using variational animal motion embedding (VAME) Granger causality analysis was performed using the MATLAB MVGC multivariate Granger causality toolbox developed by Barnett and Seth (2014) Granger causality analysis was performed on the first 5-min of each recording session to enable statistical comparison across sessions and mice To identify behavioral motifs and larger clusters of behavioral motifs (“communities”), we used the deep learning tool VAME (Luxem et al., 2022). All sessions that were included in this analysis were performed with the exact same camera setup and settings. Supplementary Videos for each behavioral community are provided in Supplementary material related to Figures 4C–F VAME produced a time series corresponding to a behavioral community label for each frame in the video sessions provided as input This time series was then used to create behavioral community videos 40 s in length: the first entry where the behavioral community label appeared in the time series was used as the video’s first frame with successive frames added until 40 s of the behavior were created—these videos thus constitute 40 s of behavioral community sequences appearing across video sessions Number of sessions and time span of recordings per mouse Results of a linear mixed-effects model of the z-scored ΔF/F of cholinergic activity with three fixed effects the logarithm of allocentric neck movement speed and the interaction between the logarithm of allocentric neck movement speed and darkness Results of a linear mixed-effects model of the z-scored ΔF/F of cholinergic activity during stationary behavioral activity with three fixed effects Results of Granger causality analysis between the logarithm of movement speed and the fiber photometry signal (as z-scored ΔF/F) of cholinergic activity in the MSDB Results of a linear mixed-effects model of Granger causality between the logarithm of movement speed (Speed) and the z-scored ΔF/F of cholinergic activity (ACh) with four fixed effects the Granger causality magnitude with two levels of direction namely from the logarithm of movement speed to cholinergic activity (Speed → ACh) and from cholinergic activity to the logarithm of movement speed (ACh → Speed) and the interaction between direction in Granger causality and lighting condition Results of a linear mixed-effects model of the z-scored ΔF/F of cholinergic activity with six fixed effects and the behavioral communities as identified through VAME Data analysis was performed using MATLAB (MathWorks) and custom-written Matlab scripts the temporal dynamics in the activity of cholinergic neurons in the MSDB are primarily a function of the animal’s movement speed with a negligible influence of visual cues we found no significant effect of darkness on speed tuning of cholinergic modulation during stationary activity these data suggest that a potential speed code by the population activity of cholinergic MSDB neurons does not distinguish between stationary periods and locomotion but instead codes for the whole range of translational neck movement speeds in the horizontal plane between 0-cm/s and the animal’s maximal running speed No such difference was found in the remaining two animals these data demonstrate that the movement speed of an animal informs the activity of MSDB cholinergic neurons and vice versa these data demonstrate that cholinergic neurons in the MSDB are more active during rearing as compared to other characteristic behaviors such as grooming or exploratory running when corrected for effects of movement speed Experiments and analyses presented in this study investigate the temporal dynamics of cholinergic activity in the septo-hippocampal system in freely foraging mice as a function of the animal’s running speed during locomotion the speed of neck movements during stationary activity and discrete behavioral motifs identified by unsupervised VAME The presented results demonstrate that the temporal dynamics in the population activity of MSDB cholinergic neurons are fast enough to align with the temporal dynamics of running speed during locomotion periods as well as temporal dynamics in the speed of neck movements during periods of stationary activity such as grooming or stationary head movements the logarithm of the speed of neck movements correlated strongly and linearly across the whole range of speed values between 0-cm/s and the maximal running speed with no detectable change in the speed tuning of cholinergic activity at the transition point from stationary activity to locomotion the quantification of temporal dynamics in the cholinergic activity and their relationship to the speed of the animal revealed that cholinergic neurons can change their activity fast enough to match changes in running speed no differences in cholinergic activity and its relationship to running speed or neck movements during stationary activity were detected during darkness an analysis adjusted for effects of movement speed of the effect of four discrete clusters of behavioral activity that correspond to exploratory running and rearing revealed that rearing is associated with higher cholinergic activity than expected from the movement speed during rearing alone Because of cholinergic effects in the medial septum fiber-photometric recordings of the activity of cholinergic projection neurons in the MSDB allows a more holistic interpretation of the temporal dynamics in cholinergic activity compared to data on the synaptic release of acetylcholine in the hippocampal formation Future studies analyzing and comparing the temporal dynamics in synaptic release of acetylcholine in the hippocampal formation will need to determine whether there are differences in the temporal dynamics of the population activity of MSDB cholinergic neurons and the temporal dynamics in the synaptic release of acetylcholine in the hippocampus and related structures the speed signal represented by firing rates of neurons in the medial entorhinal cortex was only tested on running speeds above a speed threshold of 3-cm/s a potential speed code by theta frequency or theta amplitude is restricted to periods of locomotion due to the absence of theta rhythmic activity during most stationary activities such as grooming the speed of head movements or the speed of changes in body position is likely an important factor for path integration even if those movements occur while the mouse remains stationary An alternative—not mutually exclusive—interpretation of the current data is that the activity of MSDB cholinergic neurons is primarily correlated to physical activity instead of the logarithm of movement speed This interpretation is supported by the fact that cholinergic activity remains strongly and linearly correlated to the logarithm of the speed of neck movements during stationary activity Future experiments need to address questions related to the collinearity of movement speed and physical activity those studies showed a change in the gain of speed tuning of absolute firing rates during darkness Since the analysis of fiber-photometry data requires the normalization of cholinergic activity we cannot compare absolute values of cholinergic activity across sessions It thus remains to be tested whether the absence of visual inputs can change baseline levels of cholinergic activity or the gain in the speed tuning of cholinergic activity there is an alternative explanation that deserves to be considered the mouse moves vertically instead of horizontally Due to the centered position of the camera used for the tracking of mice Future studies need to address the question whether the observed increase in cholinergic activity during rearing is primarily due to the cognitive demand of processing sensory information or encoding novel memories or due to coding the movement speed in the vertical axis The raw data supporting the conclusions of this article will be made available by the authors The animal study was reviewed and approved by the Institutional Animal Care and Use Committee for the Charles River Campus at Boston University All authors contributed to the article and approved the submitted version This work was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (grant no as well as grants from the National Institute of Mental Health NIH MH120073 as well as US Office of Naval Research grants ONR MURI N00014-16-1-2832 Heinz Beck for sharing their technical knowledge on constructing a custom-built fiber-photometry system The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fncir.2022.957441/full#supplementary-material Supplementary Figure 1 | Visualization of fiber track position and colocalization of jGCaMP7s and ChAT immunostaining Each row shows data on medial septal slices from one mouse Magenta colors indicate positive immunolabeling for choline acetyltransferase (ChAT) a marker for cholinergic neurons; green colors indicate presence of jGCaMP7s Note that jGCaMP7s expression is largely confined to ChAT-positive cholinergic neurons (78 ± 6% jGCaMP7s-positive neurons were co-labeled for ChAT; mean ± s.e.m; n = 4 mice; total of 437 cells from 1 to 3 slices per mouse; note that this is likely an underestimation because cells showed signs of cell death due to overexpression of jGCaMP7s) The same images provide histological verification that the optical fiber tip was located within the medial septum Supplementary Figure 2 | Differences in movement speed across behavioral clusters Violin plots show the distribution of movement speeds associated with each behavioral cluster during open field exploration identified by VAME Boxplots within violin plots indicate the 25th–75th percentiles Horizontal solid white lines indicate the medians of the distributions Adaptive integration of self-motion and goals in posterior parietal cortex Muscarinic tone sustains impulse flow in the septohippocampal GABA but not cholinergic pathway: Implications for learning and memory The MVGC multivariate 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septo-hippocampal system Copyright © 2022 Kopsick, Hartzell, Lazaro, Nambiar, Hasselmo and Dannenberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Holger Dannenberg, aGRhbm5lbmJAZ211LmVkdQ== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 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Volume 11 - 2017 | https://doi.org/10.3389/fncir.2017.00102 This article is part of the Research TopicNeuromodulation of Circuits in Brain Health and DiseaseView all 35 articles This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons Rather than focus on these computational hypotheses we aim to emphasize the broad scope of experimental data concerning the heterogeneity of different circuits and the cellular level modulatory effects of muscarinic and nicotinic receptors that will need to be addressed in future computational hypotheses very similar to the situation observed in rodents We will therefore begin our discussion of cholinergic modulation of neurons in the hippocampus and associated cortical regions with a discussion of the regulation of theta oscillations by ACh and its implication for memory processes which are the hallmark of a hippocampal network state characterized by the absence of theta oscillations We hypothesize that these changes act together to promote the processing and encoding of novel information into episodic memory We will therefore briefly discuss the general function of theta oscillations for memory processing and then continue our discussion on the cellular effects of ACh and behavioral consequences Taken together with the positive effects of hippocampal ACh on synaptic plasticity and theta oscillations these data favor a model in which high levels of ACh promote an encoding state of the entorhinal-hippocampal network these receptors are also found at different cellular compartments It is therefore a difficult task to decipher the individual contributions of all these factors to the overall network effects of ACh We will begin the discussion of the different cellular effects of ACh with a description of the nicotinic and muscarinic receptor types in the hippocampal formation and the functional consequences of their activation and will then summarize the cholinergic effects on the various interneuron subtypes in hippocampus and neocortical regions these experiments provide evidence for functional somato-dendritic α7 nAChRs on DG granule as well as hippocampal pyramidal cells and balancing the excitatory gain through divisive (or arrhythmic) inhibitory control Their pivotal role in local computation lies in their ability to innervate specific sublaminar populations as well as subcellular compartments cholinergic modulation of interneuron activity can have strong influences on local network computations there is still a limited understanding of the functional role of the differential cholinergic responses in the different subtypes of interneurons we summarize some of the current observations of cholinergic effects on different interneuron subtypes in hippocampus and neocortex although this regulation is likely indirect through a disinhibitory circuit involving vasoactive intestinal peptide (VIP) positive cells In summary, the subtype-specific cholinergic modulation of interneuron activity can have strong influences on network dynamics in the hippocampus and other cortical structures. Evidence for this was given recently by an in vivo study from Lovett-Barron et al. (2014) in which aversive stimuli were shown to activate CA1 O-LM interneurons via cholinergic input leading to inhibition of the distal dendrites of CA1 principal cells which was necessary for successful fear learning High acetylcholine (ACh) levels enhance encoding and suppress consolidation dynamics in the hippocampus Schematic drawing of a transverse slice of hippocampus with the main circuit connections and locations of muscarinic and nicotinic receptors shown recurrent excitatory hippocampal activity leads to retrieval and consolidation of previously stored information which can support the consolidation of memory during sharp wave ripples activity (ripple event schematically depicted in lower left panel) (B) High ACh levels result in nicotinic enhancement of mossy fiber and perforant path inputs thereby potentiating afferent input synapses in the hippocampus which favors the encoding of novel information muscarinic depolarization of interneurons and muscarinic presynaptic inhibition of synaptic potentials at recurrent and Schaffer collateral synapses result in suppression of recurrent excitation associated with retrieval of information muscarinic and nicotinic excitation of interneurons results in reduced but temporally more precise spiking activity of pyramidal cells during ongoing theta oscillations (schematically depicted in lower right panel) See text for a more detailed description of receptor distributions and functions Principal cells with dendrites schematically depicted in gray these data support the view that cholinergic signaling is important for the rapid updating of place cells when visual cues or object locations differ across spatial contexts or when spatial locations are relevant to memory-guided behavior allowing enhanced NMDA receptor activity and eventually leading to a facilitation of LTP induction Cholinergic receptor activation also enhances spike backpropagation, and thereby affects the amplitude and duration of spike train-evoked Ca2+ changes in apical dendrites, thus affecting synaptic integration and plasticity (Tsubokawa and Ross, 1997) Further follow-up experiments performed in vitro confirmed the necessity of Ca2+ elevations in astrocytes for LTP induction at the Schaffer collateral synapse in the hippocampus as previously shown for synapses in the barrel cortex Astrocytes in the hippocampus sense the wakefulness-dependent activity of septal cholinergic fibers through the α7-nAChR which acts as a co-agonist at the NMDA receptor astrocytes provide a link between cholinergic activity and NMDA receptor function This is particularly interesting for the understanding of schizophrenia a neurological disorder characterized by NMDAR hypofunction Given the outstanding role of ACh for the modulation of cortical and subcortical brain regions, it is not surprising that cholinergic dysfunction is correlated with various neurological and psychiatric disorders including depression, schizophrenia, epilepsy and Alzheimer’s disease (AD). In this review we will focus our discussion on AD and epilepsy, but see Higley and Picciotto (2014) for a recent discussion of cholinergic dysfunction in depression and schizophrenia septal cholinergic input onto O-LM interneurons was shown to be necessary for fear conditioning induced spine gain on O-LM interneurons and application of cevemeline significantly improved memory deficits in the APP/PS1 mice decreased cholinergic drive onto O-LM interneurons contributes to rewiring and memory deficits under AD-like conditions Understanding the physiological function of the septo-hippocampal cholinergic system thus remains an important step in basic research As reviewed here, physiological data demonstrates robust neuromodulatory effects of the activation of muscarinic and nicotinic receptors within cortical circuits including the hippocampal formation. These modulatory effects appear important to the encoding of new information, based on changes in network circuit dynamics as reviewed in previous articles (Hasselmo, 2006) The heterogeneity of these effects on different subtypes of neurons will require future computational modeling to develop more detailed computational hypotheses of the function of these modulatory effects These can be tested in experimental studies exploring the functional role of the strong neuromodulatory effects observed in physiological studies All authors conceived and wrote the review This research was supported by a grant from the National Institutes of Health (Grant No MH061492) and Office of Naval Research (Grant No and Deutsche Forschungsgemeinschaft (DFG; Project No The article includes contents from the dissertation by Dannenberg (2015) Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices pain and stress on hippocampal extracellular acetylcholine levels in male rats Age-related changes in rhythmically bursting activity in the medial septum of rats Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task Grid cell firing patterns signal environmental novelty by expansion Possible role of acetylcholine in regulating spatial novelty effects on θ rhythm and grid cells Cholinergic modulation of synaptic inhibition in the guinea pig hippocampus in vitro: excitation of GABAergic interneurons and inhibition of GABA-release PubMed Abstract Synaptic muscarinic response types in hippocampal CA1 interneurons depend on different levels of presynaptic activity and different muscarinic receptor subtypes Activation of muscarinic receptors by ACh release in hippocampal CA1 depolarizes VIP but has varying effects on parvalbumin-expressing basket cells Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus Cholinergic excitation of mammalian hippocampal pyramidal cells Cholinergic pharmacology of mammalian hippocampal pyramidal cells Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cells Coherent θ oscillations and reorganization of spike timing in the hippocampal- prefrontal network upon learning and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity Low-frequency θ oscillations in the human hippocampus during real-world and virtual navigation Specific lethality for cholinergic neurons in the basal forebrain of the rat Neuropathological stageing of Alzheimer-related changes γ (40–100 Hz) oscillation in the hippocampus of the behaving rat Muscarinic blockade slows and degrades the location-specific firing of hippocampal pyramidal cells Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone Muscarinic amplification of fast excitation in hilar neurones and inhibition in granule cells in the guinea-pig hippocampus Facilitation of long-term potentiation by muscarinic M1 receptors is mediated by inhibition of SK channels Ceramic-based multisite microelectrode arrays for simultaneous measures of choline and acetylcholine in CNS Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum Cholinergic modulation amplifies the intrinsic oscillatory properties of CA1 hippocampal cholecystokinin-positive interneurons M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats Brain nicotinic receptors: structure and regulation Cholinergic induction of θ-frequency oscillations in hippocampal inhibitory interneurons and pacing of pyramidal cell firing Chauvière Early deficits in spatial memory and θ rhythm in experimental temporal lobe epilepsy Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation M1-like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate 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hippocampus An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission Enhancement of encoding and retrieval functions through θ phase-specific manipulation of hippocampus θ phase precession in hippocampal neuronal populations and the compression of temporal sequences doi: 10.1002/(SICI)1098-1063(1996)6:2<149::AID-HIPO6>3.0.CO;2-K 3-D reconstruction of the cholinergic basal forebrain system in young and aged rats Defined types of cortical interneurone structure space and spike timing in the hippocampus Hippocampal neurotransmitter efflux during one-trial novel object recognition in rats Do septal neurons pace the hippocampal θ rhythm Object and place memory in the macaque entorhinal cortex PubMed Abstract Szabó Distinct synaptic properties of perisomatic inhibitory cell types and their different modulation by cholinergic receptor activation in the CA3 region of the mouse hippocampus Switching between “On” and “Off” states of persistent activity in lateral entorhinal layer III neurons Synaptic co-transmission of acetylcholine and GABA regulates hippocampal states CrossRef Full Text | Google Scholar Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo Persistent neural activity in head direction cells Comparisons of head direction cell activity in the postsubiculum and anterior thalamus of freely moving rats doi: 10.1002/(sici)1098-1063(1998)8:2<87::aid-hipo1>3.0.co;2-4 Age-related decline in cholinergic synaptic transmission in hippocampus Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum Muscarinic modulation of spike backpropagation in the apical dendrites of hippocampal CA1 pyramidal neurons serotonin and GABA axon terminals in the stratum radiatum of adult rat hippocampus (CA1) Presynaptic inhibitory effect of acetylcholine in the hippocampus PubMed Abstract | Google Scholar Vallés Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer’s disease: rationale and current status Muscarinic acetylcholine receptor-expression in astrocytes in the cortex of young and aged rats Vandecasteele Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances θ oscillations in the hippocampus The presence of pacemaker HCN channels identifies θ rhythmic GABAergic neurons in the medial septum Vilaró Localization of M5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry Differential regulation of subtypes m1–m5 of muscarinic receptors in forebrain by chronic atropine administration β-amyloid1–42 binds to α7 nicotinic acetylcholine receptor with high affinity Implications for Alzheimer’s disease pathology Amyloid peptide Aβ(1–42) binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors Novel insights into muscarinic acetylcholine receptor function using gene targeting technology Evoked slow muscarinic acetylcholinergic synaptic potentials in rat 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by Muscarinic and Nicotinic Receptors Received: 01 October 2017; Accepted: 27 November 2017; Published: 13 December 2017 Copyright © 2017 Dannenberg, Young and Hasselmo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) provided the original author(s) or licensor are credited and that the original publication in this journal is cited *Correspondence: Holger Dannenberg, aGRhbm5lbmJAZ21haWwuY29t Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish 1/5South Haven football preview 2024.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Matthew Ehler | mehler@mlive.comSOUTH HAVEN MI – As the 2023 season moved along last year South Haven’s well-planned blueprint became cut-and-dried: put the ball in No When the Rams’ varsity football team takes the field this fall they’ll be without Brady Dannenberg and Xavion Harrington the team’s leading do-it-all rushers from last season but what they will flex is a fresh bevy of multi-faceted and dynamic talents “We could completely pound on people last year but we don’t have two backs that weight 200-plus pounds this year,” South Haven head coach Mark Eddy said but we’re just going to do it in a different way “We just want to be a little bit more diverse.” After hosting its first playoff game since 2007 last fall South Haven expects to keep opponents guessing by spreading the wealth and banking on several of its 13 returning starters to all play their part in hopes of an even better 2024 season “Instead of a couple of kids that can do some things we have a bunch of kids that can do things,” Eddy said the Rams will unveil an all-new corps of skill talents –– a group that will be tasked at replacing over 2,000 yards rushing and 28 touchdowns from Harrington and Dannenberg That all starts with their new signal caller a senior that opens the Rams’ playbook and adds an elevated level of intelligence to the position he’s super inquisitive and he watches a lot of film He understands how it’s all supposed to work together and so we’ve added more to the playbook because of that At his disposal will be a flurry of weapons including a new backfield that features juniors Jacob Bosma is fresh off an all-conference season at cornerback and will also play out wide as a receiver to give the Rams a vertical threat to stretch the field “Super smart and reads his keys and tackles really well,” Mark said “He’s always in the right spot and he lives in the weight room.” so we’ll be able to spread the ball out and stretch the field more,” Elijah added said it’s not just that this year’s squad’s versatility that’s dangerous “The team has more of a connection with each other,” junior Jacob Bosma said “And we can spread the ball out more than we could last year Perhaps the team’s X-factor will come from the production of senior tight end Mathis Bray 245-pound matchup nightmare that Mark said added some extra speed this spring by joining the track and field team “He’s going to be a matchup problem because he can block Senior Gavin Covey returns to anchor the Rams in the trenches while incoming juniors Christopher May and Mark Harrell are expected to bolster the offensive line “We just have a lot of kids that can do a lot of different things and I don’t think anyone of them are selfish,” Mark said because you could have a pretty good athlete but they don’t work as hard as they should Junior kicker August Zoet remains a dark horse weapon –– he kicked the game-winning field goal to beat Kalamazoo United at the buzzer in the Rams’ regular season finale last season And while some might be inclined to think South Haven’s 2023 season was a one-and-done type of year the new wave of Rams believe it was only the beginning “We’re holding ourselves to that same standard but I think everybody in their own heads wants to do better than we did last year,” Bosma said and I think a lot of people in the community want to help with it too.” Now in Mark’s fifth season as Rams head coach the program has been fully immersed in the culture and has a full grasp on concepts and the set of standards it’s about instilling the belief that they can represent the Lakeshore on the grandest stage “We’re trying to incorporate the idea that these kids could be champions,” Mark said 2023 review: The Rams enjoyed one of their better seasons in recent memory thanks to a solid in-conference record and a much-improved second half of their season South Haven went on a three-game winning streak by beating Allegan Parchment and Watervliet before splitting their final two games with Constantine and Kalamazoo United South Haven then dropped their home playoff game against Berrien Springs 2024 outlook: With plenty of new faces at important positions it’ll be interesting to see just how well South Haven will fare in the always-tough SAC-Lakeshore The good news is their schedule is much less daunting than last season secure wins in two of their first three games –– they’ll open with Dowagiac before back-to-back games against Holland and Coloma Conference play will very much decide the Rams’ playoff fate as they’ll travel to both Constantine and Parchment before home games against Watervliet and Kalamazoo United If the Rams can make it through that stretch above .500 their path toward a second consecutive playoff berth looks promising The key to it all: which player will emerge as the Rams’ go-to playmaker Use of and/or registration on any portion of this site constitutes acceptance of our User Agreement, (updated 8/1/2024) and acknowledgement of our Privacy Policy, and Your Privacy Choices and Rights (updated 1/1/2025) © 2025 Advance Local Media LLC. All rights reserved (About Us) The material on this site may not be reproduced except with the prior written permission of Advance Local Community Rules apply to all content you upload or otherwise submit to this site YouTube's privacy policy is available here and YouTube's terms of service is available here Ad Choices Half Hollow Hills West in the Class AA State Final girls volleyball championship at the Cool Insuring Arena in Glens Falls .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Connor Pignatello | cpignatello@syracuse.comGlens Falls, N.Y. — Kalyna Dannenberg took a pair of deep breaths wiped her hands on her jersey and stepped up to serve Fayetteville-Manlius girls volleyball was one point away from its first state title in program history and as three balls slipped through F-M’s hands and onto the hardwood at Cool Insuring Arena Section XI’s Half Hollow Hills West reeled off three straight points to win the fifth and final set of the Class AA championship game and complete a two-sets-to-one comeback late into the night on Saturday in Glens Falls an errant Hills West pass away from emptying its bench and mobbing the court and when the Hornets held match point up 14-13 F-M coaches hyped up the crowd from the sideline As F-M watched Hills West accept its trophy “We gave ourselves a chance to win,” McHerron said “And we put ourselves in a position where we could win but at least we could say we had the opportunity.” Half Hollow Hills West Class AA State Final girls volleyballSaturday night could have marked Fayetteville-Manlius’ first state championship this Hornets team advanced farther than any other in program history F-M had never even been to a state final four And after a sectional title game loss to West Genesee last November “We didn’t expect to get here at the beginning of the season The Hornets ended the regular season with a 9-3 record including an undefeated mark against schools in Class AA and below They lost twice against Class AAA sectional champ Baldwinsville and split meetings with AAA sectional finalist Liverpool in addition to a win over Cicero-North Syracuse Dannenberg said the team “clicked” after its four-set victory over Liverpool on senior night F-M beat Oswego 3-1 and West Genesee 3-0 to claim the Section III title and then swept Niskayuna in the regional round to advance to Glens Falls the Hornets beat Minisink Valley in straight sets and earned a three-set win over Brighton to set up a meeting with Hills West though both teams had already qualified for the championship game based on their records in pool play F-M beat Hills West in three sets in a match where both teams played their second-stringers but Hills West forced F-M into some sloppy defense over the latter part of the set and won it 25-17 F-M responded right away in the second set taking 11 of the final 13 points to tie the match up with a 25-13 win winning nine of the next 10 points to tie the set at 23-23 The Hornets pulled ahead at 25-24 and finally took the set on their third set point F-M never led in the set and trailed by as many as 11 points before losing it 25-17 to set up a winner-take-all fifth set for the state title Though each team had long streaks of success across the first four sets but Hills West scored four straight to take the lead right back and then neither team took a lead of more than one point the rest of the way When F-M blocked a Hills West spike to force match point at 14-13 Hills West called timeout and the Hornets crowd crescendoed “There was kind of a lot going through my head and he calmed me down a lot,” a teary Dannenberg said of serving for the match so just focusing on getting it over and in just trying to keep the game going so we could hopefully win it.” on Saturday against Section I’s Blind Brook Baldwinsville’s 2013 squad was the last Section III team to win the state title in Class AA the quest for the program’s first state championship continues next season Dannenberg said her younger teammates can draw on this year’s successes “Once they saw that we could do it,” Dannenberg said “I think they’ll definitely be able to get back here next year.” Contact Connor Pignatello anytime: Email | X Use of and/or registration on any portion of this site constitutes acceptance of our User Agreement, (updated 8/1/2024) and acknowledgement of our Privacy Policy, and Your Privacy Choices and Rights (updated 1/1/2025) © 2025 Advance Local Media LLC. All rights reserved (About Us) Community Rules apply to all content you upload or otherwise submit to this site Ad Choices Andrew Dannenberg to discuss his current work and interest in breast cancer research Q: Tell us about yourself as a scientist and how you became interested in breast cancer research Did you ever seriously consider another kind of career than that of the sciences A: I have had a longstanding interest in cancer prevention with an emphasis on the connections between chronic inflammation and cancer My research has focused on a class of bioactive lipids known as prostaglandins which have been linked to both inflammation and numerous malignancies we showed that when breast cells became malignant and formed tumors a gene known as cyclooxygenase-2 (COX-2) was turned on leading to increased production of prostaglandins This simple finding sparked a focused effort in breast cancer research with the overarching goal of developing evidence-based risk reduction strategies we believe that by inhibiting the formation of prostaglandins it may be possible to reduce the formation I never seriously considered a career outside of the sciences After attending medical school and being trained as an internist I needed to decide whether to pursue clinical medicine or laboratory science I love asking questions and gain enormous satisfaction from finding answers this passion led me to pursue a laboratory research career but with a focus on clinically relevant questions Q: Briefly describe your BCRF-funded research project What are some laboratory and/or clinical experiences that inspired your work What are your primary goals for this research A: The use of inhibitors of cyclooxygenase (COX) enzymes including aspirin has been associated with a reduced risk of breast cancer The prostaglandin products of COX enzymes stimulate the formation of aromatase the enzyme that makes estrogen (this female hormone can drive breast cancer formation and growth) Because widely available anti-inflammatory drugs inhibit COX enzymes and therefore may lower estrogen levels our work helps to explain the observation that the risk of estrogen receptor-positive breast cancer may be reduced among aspirin users Clifford Hudis of Memorial Sloan-Kettering Cancer Center with BCRF support we have extended this line of investigation to try to understand the link between obesity we have been able to translate some of our preclinical findings to women we hope to be able to develop mechanism-based risk reduction strategies I am absolutely convinced that science will lead to effective preventive interventions I have had loved ones develop breast cancer I can think of no better way to spend my time and energy than pursuing ways to reduce the breast cancer burden Q: Are there specific scientific developments and/or technologies that have made your work possible What additional advancements can help to enhance your progress we employ a variety of broad experimental approaches called “-omics” in our research These large-scale studies include genomics (studying genes) or fats) and metabolomics (studying metabolism) One of my goals is to noninvasively image inflammation but this is likely to require additional technological advances The ability to noninvasively image inflammation would enable us to monitor the efficacy of anti-inflammatory agents an important step in preventive drug development Q: What direction(s)/trends do you see emerging in breast cancer research in the next 10 years A: Continued research will allow us to personalize not only therapy as is already happening but also prevention These advances in risk reduction will be meaningful sooner than many observers now believe Q: What other projects are you currently working on we are attempting to elucidate the role of inflammation in driving the spread (metastasis) of established breast cancers we may be able to suppress both tumor formation and metastasis we are exploring the potential of dietary factors to modulate the expression of genes implicated in inflammation A dietary intervention is obviously an attractive approach (and long sought!) to prevention Q: How close are we to preventing and curing all forms of breast cancer A: Breast cancer represents multiple diseases I believe we will continue to see significant incremental advances including many more cures We already know we can prevent some kinds of breast cancer using anti-estrogen therapies and there is every reason to believe that similar approaches will be validated for other subtypes how has BCRF impacted breast cancer research A: BCRF is a very important organization that is catalyzing important advances Funding from BCRF provides investigators with the flexibility and freedom to pursue innovative science that wouldn’t otherwise be possible BCRF helps to break down barriers and catalyze collaborative team science funding from BCRF has made an enormous difference in helping our laboratory to make progress Preclinical results from this study was published online in Cancer Prevention Research a journal of the American Association for Cancer Research Dannenberg’s current research project funded by BCRF.  I give to the Breast Cancer Research Foundation federal tax identification number 13-3727250 Breast Cancer Research Foundation28 West 44th Street, Suite 609, New York, NY 10036 General Office: 646-497-2600 | Toll Free: 1-866-346-3228bcrf@bcrf.org | BCRF is a 501 (c)(3) | EIN: 13-3727250 Link IconCopy linkFacebook LogoShare on FacebookXShare on XEmailShare via EmailLink copied to clipboardJames L has died at 97 He practiced and taught pediatric dentistry for five decades and championed conservation and community activism former professor of endodontics and pediatric dentistry at the University of Pennsylvania of a perforated colon at Chestnut Hill Hospital Dannenberg saw countless dental patients in his Center City office rushed to emergency jobs at homes and elsewhere and served as a stateside military dentist during the Korean War He became an expert on children’s teeth and was affiliated for years with Children’s Hospital of Philadelphia maintenance of health and prevention of disease or trauma is superior to remedial therapy.” He was a member of the American Board of Endodontics and the Omicron Kappa Upsilon honor society and others to remote southern Mexico and volunteered to treat indigenous people “He always put his patients first,” said his son David At Penn’s School of Dental Medicine, Dr. Dannenberg taught children’s dentistry and focused on clinical instruction one day a week for 50 years. A natural teacher and collaborator, he made personal connections easily and told the Pennsylvania Gazette that he tried to demonstrate “the personal satisfaction that comes with successful hard work” for his students His family owned a small farm in Upper Dublin when he was young Dannenberg learned to appreciate nature and conservation He went on to become a volunteer agricultural mentor at W.B Saul High School in Roxborough for 20 years and his family endowed a support fund in his name for the Virginia-based Student Conservation Association recycle ethos before it was a marketing tool,” his daughter Ann said His son said: “He recognized the importance of the natural world.” He earned his dental school prerequisites at Pennsylvania State University and graduated from Penn’s School of Dental Medicine in 1948 He enlisted in the Army after Penn and served two years stateside as a military dentist They lived in Germantown at first and moved to West Mount Airy in 1958 hike and fish with family and friends in the Adirondack Mountains he built his own sailboat in the living room The family walked often near the Wissahickon Creek on Sundays and he and his son spent memorable afternoons together taking on household projects “He got satisfaction from doing things himself,” his son said He supported the Wharton Esherick Museum in Malvern and helped friends meet educational financial obligations He also inspired and encouraged his niece to become a dentist He wrote letters to the editor of The Inquirer and Daily Pennsylvanian about diversity was “to respect other people and their skills and attributes and to treat them well and with courtesy and compassion.” In 2014, Dr. Dannenberg told the Pennsylvania Gazette: “At 87 I am satisfied with the life I have led and continue to lead I have been rewarded by the respect of my colleagues His daughter Ann said: “Family and friends were passions of his Dannenberg is survived by six grandchildren Donations in his name may be made to the Student Conservation Association Dannenberg Family Fund Rob is an independent consultant on geopolitical and security risk he was a managing director and head of the Office of Global Security for Goldman Sachs Rob was an advisor to Goldman Sachs and the firm’s clients on geopolitical risk Rob worked at BP plc where he was the director of International Security Affairs he worked for 24 years at the Central Intelligence Agency (CIA) where he served in several leadership positions including chief of Operations for the Counterterrorism Center and chief of the CIA’s Information Operations (Cyber) Center  He is a recipient of the Distinguished Career Intelligence Medal the Donovan Award for Operational Excellence the George HW Bush Award for Excellence in Counterterrorism and the Director’s Award Rob is a member of the Board of Advisors to the Director of the National Counterterrorism Center  Rob is President of Quint Advisors and is a frequent contributor to The Cipher Brief       University of Colorado at Boulder, 121 UCBUniversity Club A5Phone: 303-492-7295 / Fax: 303-492-4268Contact Us IAFS Faculty and Staff Resources CU Boulder acknowledges that it is located on the traditional territories and ancestral homelands of the Cheyenne, Arapaho, Ute and many other Native American nations. Their forced removal from these territories has caused devastating and lasting impacts. Full CU Boulder land acknowledgment University of Colorado Boulder Privacy • Legal & Trademarks • Campus Map University of Colorado Boulder Peermusic has appointed Alison Dannenberg-Frost as Vice President The news was announced on Thursday (September 14) by Kathy Spanberger, President & Chief Operating Officer, peermusic Alison Dannenberg-Frost brings 10+ years’ experience working in Film & TV and most recently served as Head of Sync & Licensing at Glassnote Entertainment Group Alison worked in various Film & TV Creative positions at peermusic for eight years The exec will be based out of peermusic’s Burbank office Alison Dannenberg-Frost will be responsible for placing the copyrights of peermusic songwriters into projects for media while “leveraging her vast relationships with music supervisors production music houses and video game entities” Dannenberg-Frost has also worked with artists in creating original music for sync the likes of which have been placed in promos and films across major networks and streaming platforms The exec has pitched and placed the music of such iconic music creators such as Sons of Sonix (whose credits include Justin Bieber and Jennifer Lopez); BJ The Chicago Kid; Molotov; Thee Sinseers; Corey Hart; Malcom McLaren; Beny More; Donovan; Hoagy Carmichael; Jimmie Rodgers; Tito Puente; David Foster and more into major synch projects Dannenberg-Frost has also held roles as Director Dannenberg-Frost worked at Vin Di Bona Productions Reporting into Dannenberg-Frost will be Oscar Martinez Film/TV and Hispanic Advertising; Steve Torres I’ve had the opportunity to work alongside of and learn from some of the industry’s best music publishing executives.” Alison Dannenberg-Frost said: “The support and career opportunities that I’ve had over my many years at peermusic has been incredible I’ve had the opportunity to work alongside of and learn from some of the industry’s best music publishing executives “When the opportunity came up for this position knew that I was 100% heading back home to peermusic to work with the incredible synch team that we’ve built I have seen first-hand the level of proactive service and dedication that peermusic brings to generating synch income for its artists and songwriters and I’m thrilled that I can continue to be a part of it “I would like to thank Kathy for this opportunity and I look forward to continuing to advocate for peermusic’s legendary songwriter roster in conjunction with the entire creative staff.” “Alison is known for her ability to proactively champion peermusic songwriters for unique opportunities.” Kathy Spanberger said: “Alison knows the peermusic song catalog like the back of her hand and has a proven ability to match the perfect peermusic song with the perfect scene to stimulate synch income for our songwriters “Alison is known for her ability to proactively champion peermusic songwriters for unique opportunities She’s a hard-working team player who has already made significant contributions to peermusic’s success in the synch world We couldn’t be happier to have Alison back at peermusic and in this important role for our team.”Music Business Worldwide Stay on top of the real stories shaping the music industry: Join over 60,000 industry professionals who rely on MBW's FREE daily newsletter and alert emails for essential insights and breaking news Karan Dannenberg of Karan Dannenberg Clothier has announced that her beloved store located at the Hyatt Regency Bellevue will be closing its doors at the end of February This closure marks the end of an era for the iconic clothing boutique which has had a loyal following since its opening in 1998 Karan Dannenberg’s journey in the retail industry spans decades beginning with her early days as a wholesale representative and later transitioning into curating and selling travel wardrobes out of her own home Her talent for buying and her understanding of her clientele have been the cornerstone of her success allowing her to put together wardrobes for her customers and earn a reputation as an exceptional buyer the decision was made to relocate the retail store from Belltown to Bellevue citing safety concerns and a desire to better serve her clientele The move proved to be an important moment in Karan’s career as the Hyatt Regency Bellevue location provided a safe and welcoming environment for her customers many of whom had been hesitant to shop at the Belltown location due to an increase in safety issues Dannenberg shared that she is retiring and will pursue other passions While the news has come as a disappointment to her loyal patrons there has also been an outpouring of support and well-wishes Karan expressed the possibility of continuing her work in a more personalized way such as offering personal shopping services She emphasized the need for a period of rest and reflection before making any decisions Something impressive about Karan Dannenberg Clothing has been its ability to cater to a range of generations offering colorful and unique pieces that are not found elsewhere Dannenberg’s keen eye for distinctive items has set her store apart with special orders and one-of-a-kind pieces becoming a trademark of her brand From custom-made hats from New York to handcrafted jewelry from Italy she has always had a strong dedication to providing unparalleled customer service Thank you very much for this lovely article i appreciate it very much It is a very emotional time to close when business is great Karan gave so much of her free time with charitable causes and contributions to the local community besides tending shop She always went the extra mile in providing for her loyal customers and did her best to help make Seattleite ladies more stylish Be good to yourself rest and enjoy your new journey.❤️❤️❤️❤️❤️❤️ Congratulations Karan for your amazing success to date and we strongly suspect you are going to love your next chapter “Life is like a Merry-Go-Round – and I’m not ready to get off the horse yet” born to Zelpha Mae Smith Haas and Clifford Andrew Haas in Smith County She was raised a Kansas farm girl and was always very proud of that Norma and Raymond lived in several cities during their life together They were the proud parents of five children: loved square dancing and traveled the US attending Square Dancing Conventions The last seven years of her life was spent at Carrington Court Assisted Living where she made many friends and considered them family They all said she was the SPARK that kept everyone on their toes Mom lived life on her own terms and at one time stated  “I told them I’m here to raise a little hell” Norma is preceded in death by her husband Raymond; sons Alan & Cary; and grandson Christopher We would like to thank the staff and caregivers at Carrington Court and also Active Hospice Retraction Watch Tracking retractions as a window into the scientific process Two cancer researchers who formerly worked at Weill Cornell Medicine in New York City published 12 papers with fake data that amounts to research misconduct ORI found that Andrew Dannenberg “engaged in research misconduct by recklessly reporting falsified and/or fabricated data” in the papers, and Kotha Subbaramaiah “reused Western blot images from the same source and falsely relabeled them to represent different proteins and/or experimental results.”  The published findings for both scientists include the same extensive list of duplicated images in a dozen papers Dannenberg and Subbaramaiah retired from Weill Cornell in late 2020 and early 2021 Dannenberg had received approximately $8 million in grants from the National Institutes of Health since 1995; Subbaramaiah received more than $1 million between 2005 and 2009.  Elizabeth McEvoy at the Boston firm Hinkley Allen Dannenberg did not generate the problematic data nor prepare the figures necessitating retraction of any of the nine articles you reference; those data were prepared by another investigator who is referenced in two of the Retraction Notices Dannenberg believed those data were valid and reliable and only came to learn more recently of concerns pertaining to those data.  McAvoy has not yet responded to our request for comment on ORI’s findings [See update at the end of this post.] However the latest action suggests investigators were not satisfied Dannenberg was an innocent bystander in his colleague’s deception.  ORI’s findings state that Dannenberg agreed to have his research supervised for seven years – an unusually long term Subbaramaiah agreed to “exclude himself” from federal contracting or receiving other government funding for the same length of time The fraudulent data in the retracted papers were generated and prepared by a faculty member in Dr Dannenberg’s former laboratory, not by Dr Dannenberg believed the data produced in each of the implicated papers/grants were accurate and reliable when they were submitted.  Dr Dannenberg would never have published the data had he suspected or known that the data were manipulated or fabricated.  Although Dr Dannenberg believes he was careful and thorough in supervising data generation in his lab he has reached a settlement with the Office of Research Integrity to allow him to continue pursuing his scientific endeavors in PHS-funded science and avoid the time and burden of further litigation.  window.dojoRequire(["mojo/signup-forms/Loader"] function(L) { L.start({"baseUrl":"mc.us12.list-manage.com","uuid":"4f35c1f2e9acc58eee0811e78","lid":"a15d7de264","uniqueMethods":true}) }) but your article fails to say if the papers conclusions are wrong ,or if the figures they misused were not relevant to the papers Obviously Mcvoy did not do a reasonable job of directing his team These are often the things that are “obvious” there’s plenty of less obvious results that can be falsified without anyone ever knowing And why would anyone even falsify figures if they are not relevant This site uses Akismet to reduce spam. Learn how your comment data is processed. In our press portal you can find current press releases information about fairs and events as well as studies and other publications OverviewPress Contacts Find out what drives our employees and what exactly makes Continental a great employer Job Portal Application ProcessContact & FAQ On these pages we present our investor related news and information OverviewContactAbout usServices  Here you find more information about sustainability at Continental Overview Contact On these pages we present information about our products and innovations OverviewContact Since 1871 we develop pioneering technologies and services for sustainable and connected mobility of people and their goods Find out more about our company on these pages OverviewContact This fall, Continental celebrated its 150th Anniversary. But there’s another reason for employees at the Dannenberg location to celebrate: This year, the plant is celebrating its 60th anniversary – and looking back. As the local employees tell it, Continental in Dannenberg is like a large family. In addition to cooperative working relationships, committed employees organize regular events, such as the traditional Continental bicycle tour. This summer, it was held for the 22nd time and many employees with their families took part. Skilled workers assigned here also very much appreciate the team spirit and are happy to get together for an excursion, an evening drink or sport after work. EmailThe beginnings: Production of drive belts in 1970 around 150 million meters of belts have been manufactured for the elevator industry.A lot has changed at the location over the past six decades While Continental initially only manufactured belts in Dannenberg today the technology company produces drive belts and vibration elements for its business units in ten production halls Continental invested €1.6 million for this at the beginning of the year – in the production of drive belts for wind turbines and high-rise racking systems The growth in online commerce and the trend toward automated driverless transport units in the field of intralogistics in particular are increasing demand for relevant components everything was handled by hand and in written form followed by the first computer in the late 1980s Not to mention intranet and e-mail communication within the workforce All of this is hard to imagine for employees like Heinrich Schwab The 18-year-old only started his apprenticeship in the HR department at the Dannenberg location in August “I’m excited to be part of such a large corporation and I’m very personally aware of the local working environment,” explains Schwab It is a tradition for young people to learn from experienced employees and vice versa – and has been for 150 years “We’re in the happy position that we’re always looking for people who want to work in a technical environment,” says Rolf Marwede who heads the industrial drive belt division in Dannenberg Marwede can also look back on an intensive period at the Dannenberg location we’ve delivered around 150 million meters of belts to customers for the elevator industry,” says Marwede