Laura Diez grew up in the heart of Miami amid the fabric of two cultures who had immigrated from Cuba in one of the earliest waves of boatlift migration Determined to keep their family’s Cuban heritage alive her maternal grandparents became pillars of support for the immigrant community Diez’s grandmother opened a clothing factory to employ dozens of Cuban women — a modest space that bridged livelihood and belonging amid the hum of sewing machines and the chatter of her grandmother’s protégés she absorbed profound lessons about connection and unity that shaped her understanding of building community Diez brings a community-centered approach to her work with the RMI Islands Energy Program where she serves as a senior associate She came to RMI due to her interest in the environment “My first academic love was evolution,” Diez says “I love little microevolution events like subspecies of certain animals…and the reason that subspecies come up is because a lot of the time their environments are changing So that got me thinking a lot about climate change.” That led Diez to pursue a master’s degree in climate science and solutions She then worked as the sustainability coordinator for a county government in Georgia before joining RMI Diez takes pride in RMI’s approach that is distinct from the traditional “fly in fly out” model which leaves communities ill-equipped for sustaining change the program brings key leaders to the table lays the groundwork for lasting transformation Diez and RMI colleagues at the LUCELEC utility solar site “Something that I’ve found people really take to heart [at RMI] is that our goal should be to work ourselves out of a job And that’s intimidating to say… [because] it means transferring knowledge as much as possible It means really investing in the people on the ground.” Something that I’ve found people really take to heart [at RMI] is that our goal should be to work ourselves out of a job… It means really investing in the people on the ground Diez’s mission to boost local capacity puts a spotlight on women Recent United Nations figures suggest that women and children account for 80 percent of climate refugees “They are the people using energy in the home they’re choosing the products that they’re buying.” says Diez “It’s really unfortunate to think that while women are the most impacted and the folks most reliant on clean energy they are also not being involved in solutions around it.” Beyond the disproportionate climate burdens that women experience globally women like Diez face additional challenges when aspiring to leadership roles in the energy transition The clean energy sector remains predominantly male-dominated with women accounting for just 32 percent of the workforce across all levels from executive positions to technical roles Various factors contribute to a cycle that hinders women’s ability to enter Providing them with access to training and mentorship can help reduce these inequalities advance their careers in the energy sector It’s really unfortunate to think that while women are the most impacted and the folks most reliant on clean energy they are also not being involved in solutions around it The Caribbean’s energy sector is notably lacking in gender diversity. As these island nations embark on ambitious clean energy transitions, unlocking the full potential of this transformation demands innovative approaches and fresh business models. To achieve this, greater involvement from a diverse range of talent is essential. RMI’s Caribbean-based Women in Renewable Energy (WIRE) Network advocates for expanded gender representation in C-suites and boards through ensuring a pipeline of motivated and experienced women “There is a ‘leaky pipeline,’ where women leave their roles mid-career because they don’t see shared identities represented in leadership,” Diez says She acknowledges the broader cultural and systemic challenges that inform this pipeline sharing stories of qualified women being passed over for projects due to false assumptions about family planning Diez sees WIRE’s approach as two-pronged: developing skills and building networks She recognizes that skills alone aren’t always enough so the network also aims to change the industry landscape by increasing the number of women leaders and fostering supportive professional relationships The flagship program invites 12 women each year to participate in a two-year program they transition to becoming mentors themselves creating a cohort that pairs seasoned leaders with up-and-coming professionals Diez (third from right) with members of the WIRE Mentorship Program at the annual WIRE-hosted Women in Renewable Energy Luncheon at the Caribbean Renewable Energy Forum in Miami The cohort meets in-person once per year to conduct site visits and present their final call-to-action “The call to action is ideally some sort of community-based project where you are sharing something about your experience in the renewable energy space,” explains Diez  She has seen projects ranging from trainings on gender in the workplace The scale and focus of WIRE final products vary greatly but they’re typically designed to address issues close to the participants’ hearts and relevant to their local communities tackling a range of topics from sustainable fashion to environmental justice and activist burnout Diez recording “Eco Chic” at podcast studios in Los Angeles “Storytelling allows you to better understand what someone has lived through [and] the context that climate is showing up in their life,” Diez notes She celebrates the notable shift in the climate conversation in recent years: where once the focus was convincing the public that climate change was real now the dialogue has shifted to addressing its impacts her show creates a space for empathy and understanding making the abstract concept of climate change more tangible and relatable to listeners I think my work at RMI has given me a lot of motivation because I work with communities… having so many community-facing experiences really gives me a lot of hope storytelling isn’t just about the present — it’s a tool to imagine a brighter future for island communities in her work centered on resilience and energy independence keeps her going when the fight for change gets tough “I think my work at RMI has given me a lot of motivation because I work with communities I like being able to see the impacts of something that for a long time you don’t know if you’ve impacted a region or an organization Measuring success can be very hard in this role But having so many community-facing experiences really gives me a lot of hope.” Your donation to RMI helps us continue our vital work we will keep you informed with the latest RMI news and insights through periodic email communication NEWS Corina Diez OurHouse spoke with Corina Diez Random House about what goes into marketing romance titles As an avid lover of the romance genre and a marketer behind the Rebel Blue Ranch series we asked her: what sets a romance series apart She also divulged just how community and authenticity are the building blocks of the romance landscape what’s the first step you’re taking to decide your approach Corina: I don’t know if this is specific to Random House Group but we actually start with a brainstorming session between marketing and publicity We draft a creative brief and read the title information (TI) We identify the target audience or audiences as part of this process Lyzbeth: When marketing the Rebel Blue Ranch series what struck you as unique about the series for marketing Part of the Rebel Blue Ranch series by Lyla Sage Corina: I think a big one was that this author started off as an indie author, self-publishing her work. Lyla Sage It’s not just a campaign plan; it’s a community you’re building around the characters Lyla did a great job leveraging her platforms and existing relationships with readers It’s a marketer’s dream to have that kind of foundation to work with She’s very present with readers and connects with them The cowboy romance is booming: the rich western landscapes But there’s so many other well-loved romance tropes interwoven throughout the series that we highlight for readers and that makes every book’s romance unique:  best friend’s brother Lyzbeth: Cowboys always make me feel like I could get into rom-coms “The covers tell you everything…” The covers tell you everything you need to know What do you find most exciting about the romance landscape right now I help manage the Dial Press Instagram account which publishes the Rebel Blue Ranch series The amount of mentions and stories we get tagged in for our rom-coms is amazing These readers are very active and crave the emotional connection they find in books It’s that passionate community of readers that excites me the most It’s exciting to see the space that’s being created for readers to share their excitement with one another Lyzbeth: What’s a project you’ve worked on recently that you’ve been really excited about or found really fun or successful Corina: I’m working on YOU ARE FATALLY INVITED by Ande Pliego which is out next week and thriller readers are also very passionate but it plays on often overused tropes and spins them on their head We’re seeing a lot of early reader buzz for it It’s Ande Pliego’s debut novel It got Apple’s Best Debut of the Month pick and we’re seeing a lot of early praise I can’t wait for it to be out because I think we have a great author to build in the thriller space taking all the tropes and spinning them on their head It’s a thriller at the end of the day but you can tell Andy is a thriller and mystery lover This book feels like a love letter to everyone who loves those genres too Below please find a letter submitted to Congress today (April 3 Simon & Schuster and Sourcebooks advocating… Penguin Random House partnered with Little Free Library (LFL) to celebrate a significant milestone: the installation of the 200,000th Little Free Library… The Jewish community is wonderfully diverse with individuals coming from various backgrounds and experiences Jewish people come from all over the world and reflect a beautiful… Inaugurated by the Academy of American Poets in 1996 National Poetry Month celebrates poetry and its place in American culture We’re thrilled to share that several Penguin Random House titles have been named finalists for the 37th Annual Publishing Triangle Awards — an event dedicated to… The UK’s Women’s Prize Trust announced the shortlist for the 2025 Women's Prize for Fiction a literary award championing and amplifying women's voices Columbia Journalism School and the Nieman Foundation for Journalism at Harvard announced the four winners and three finalists of the 2025 J Berkley joined the nonprofit VOW for Girls and the romance community to help end child marriage around the world It’s time to share your love for libraries an initiative of the American Library Association The Los Angeles County Sheriff’s Department has promoted Captain Justin Diez head of the Santa Clarita Valley Sheriff’s Station to the position of Commander of the LASD North Patrol Division Diez will oversee the Santa Clarita Valley Sheriff’s Station Malibu/Lost Hills and West Hollywood stations Diez is a 23-year veteran of the Los Angeles County Sheriff’s Department He was promoted to the rank of Captain and assigned to the Santa Clarita Valley Sheriff’s Station in March of 2020 Diez entered the Sheriff’s Training Academy in December of 2000 he was assigned to the Pitchess Detention Center – North County Correctional Facility He also served as a deputy at various assignments including Transit Services Bureau Community Oriented Policing Services Bureau and Operation Safe Streets Bureau Community Oriented Policing Services Bureau and Internal Affairs Bureau After being promoted to lieutenant in 2015 Lost Hills Station and the Hall of Justice Diez holds a Bachelor of Arts Degree in Sociology/Criminology from California State University Northridge and a Master of Science Degree in Criminal Justice from the University of Cincinnati Ohio Diez has been a resident of Santa Clarita Valley for over 21 years where he lives with his wife and two children He also serves on the board of the Boys & Girls Club of Santa Clarita Valley and the Santa Clarita Valley Sheriff’s Foundation Brandon Barclay has been named the temporary SCV Sheriff’s Station captain It is expected a new captain will be named for the SCV Station in the near future You can be the first one to leave a comment Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Subscribe  Gift a Subscription assistant professor of Physiology and of the Center for Molecular Medicine and Genetics at the Wayne State University School of Medicine received the Stephanie Watts Career Development Award from the American Heart Association’s Hypertension Council Conference supports early career investigators working in hypertension and cardiovascular research who show exceptional promise but may be currently unfunded or have limited access to extramural funding “Getting the award is a great recognition for me a scientist that I highly respect for her fantastic research and mentoring style I hope I can be as good a scientist and mentor as she is further in my career as a new investigator in the field of hypertension and kidney disease this is a great support and a relief to know that my peers find this proposal interesting and needed,” Dr A subcommittee nominated by the Council on Hypertension Training Advocacy Committee selects up to three finalists for the award who each give three-minute presentations at the Hypertension Scientific Sessions where judges determine the winner based on the criteria scientific merit and quality of the presentation a complimentary ticket to the Council on Hypertension Awards banquet and a complete Data Sciences International telemetry system that will allow Dr Espinosa-Diez to optimize a preclinical model of cancer-therapy-induced hypertension in a long-non-coding-RNA animal model The work will be helpful in generating preliminary data for a future R01 grant application through which she will test different models of cancer therapeutics cisplatin and VEGF inhibitors that have been previously connected to increased development of hypertension “Receiving this equipment is a great boost for my independence as I will be able to perform these experiments in the laboratory which otherwise will be very hard to optimize through collaborations,” Dr a former member of the Council on Hypertension who has advocated for the needs of trainees associated with the council Watts led to the creation of the Trainee Advocacy Committee she contributed to the planning of the Hypertension Summer School another important Council on Hypertension past initiative that helped many trainees to become highly skilled hypertension researchers Espinosa-Diez’s research focuses on non-coding-RNA and in understanding how cancer therapies shape the epigenetic landscape of vascular cells potentially giving rise to long-term vascular complications Her lab’s main goals are to explore the response of long-non-coding RNAs to different anti-cancer agents and investigating these long-non-coding RNAs’ role in vascular remodeling during disease progression Privacy and University Policies Wayne State University © 2023  For the last five Years, Diez has worn the badge of Captain for the Santa Clarita Valley Sheriff’s Station he was sworn in as commander to oversee the North Patrol Division of the Los Angeles County Sheriff’s Department  “North Patrol Division encompasses five stations Santa Clarita Malibu/Lost Hills and West Hollywood,” Diez said Diez felt spoiled to be able to work at the SCV Sheriff’s Station being able to serve alongside his deputies  “It’s special because you live here and you get to be involved with your kids sports and kids school,” Diez said “You see deputies around town all the time That’s what’s special about Santa Clarita almost everybody that works here lives here It’s a great place to be a police officer of any rank and I was very spoiled and very fortunate to get to do it at a captain rank.” who is the Santa Clarita Valley Sheriff’s Station’s  operations lieutenant will be the acting captain until a new captain is assigned Captain Justin Diez’s promotion to Commander is a well-earned recognition of his leadership and dedication to the Santa Clarita community highlights the importance of strong community ties in law enforcement It will be interesting to see how his experience shapes his new role overseeing the North Patrol Division Congrats to Captain Justin Diez on your promotion to Commander It’s been a pleasure working with you on Boys & Girls Club events and with the History Center’s projects Your Leadership and Passion for our community is most appreciated by our citizens All the best to you and your family in the upcoming chapter of life and website in this browser for the next time I comment This site uses Akismet to reduce spam. Learn how your comment data is processed. Attorney San Antonio has a long-standing relationship with Mexico. Hispanic Heritage Month celebrates Mexico's Independence each September with special programming Miguel Hidalgo y Costilla gave his grito (cry) This sparked Mexico's fight for Independence from Spain Events The Commission oversees San Antonio's celebration and commemoration of Mexico's Day of Independence Diez y Seis de Septiembre (September 16) and Hispanic Heritage Month Events promote the historical significance of Mexico's Day of Independence and include: Apply to Serve on the Commission Gonzalez Convention Center is open at 100% occupancy as of May 17 As our number one priority is the health and safety of our guests we will continue with many protocols established over the last year to ensure our facility is clean and safe for your return Please contact your sales or event manager to address any questions or concerns you may have The Office of Military & Veteran Affairs and Government Affairs Department have moved Vital Record Services will be closed on Friday Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInL’ANSE, Mich. (WLUC) - Comedian Ric Diez will be headlining a comedy show at The Extra Event Center in L’Anse next weekend A one-liner comedian with a lot of dark humor jokes Diez is famous for earning a golden ticket on the “Kill Tony” show Very self-deprecating jokes but also a lot of stuff that’s pretty personal,” Diezz said “Those of you that are used to seeing me do a minute some of the energy and the Ric Diez you know will still be there but you’ll see much more than that.” Regular tickets are $40. V.I.P tickets are $70. The show is March 22 from 8-10 p.m. ET. You can buy tickets here This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page The company promoted John Diez and Cristina Gallo-Aquino who both started as assistant controllers at the company Former Ryder System CFO John Diez began the role of president and COO at the start of the new year and an internal candidate with two decades of experience at the company took over his recent job Former SVP, Controller and Principal Accounting Officer Cristina Gallo-Aquino took on Diez’s titles of EVP and CFO on Jan. 1 as part of the promotions, according to a securities filing “Both executives bring a powerful combination of industry knowledge to their new roles, complemented by a deep understanding of Ryder’s overall business operations and how our business units collaborate,” CEO and Chairman Robert Sanchez said in a news release Sanchez was the company’s COO for nearly a year in 2012 before taking on his current roles in 2013 and the position calls for general management of the company’s three business units Diez has over two decades of experience with Ryder He started there in 2002 as an assistant controller and has served as president of the company’s dedicated and fleet management divisions Gallo-Aquino also started there in 2004 as an assistant controller and has held the roles of chief accounting officer and Fleet Management Solutions CFO Get the free daily newsletter read by industry experts The Canada-based freight giant wants to close a $4 billion to $5 billion acquisition around the end of next year before it splits its LTL and TL businesses CEO Chris Spear pledged the group would remain engaged on industry issues regardless of the outcome of the presidential race Want to share a company announcement with your peers The free newsletter covering the top industry headlines Metrics details a condition in which acquired somatic mutations in hematopoietic stem cells lead to the outgrowth of a mutant hematopoietic clone is associated with a higher risk of hematological cancer and a growing list of nonhematological disorders most notably atherosclerosis and associated cardiovascular disease whether accelerated atherosclerosis is a cause or a consequence of clonal hematopoiesis remains a matter of debate Some studies support a direct contribution of certain clonal hematopoiesis-related mutations to atherosclerosis via exacerbation of inflammatory responses whereas others suggest that clonal hematopoiesis is a symptom rather than a cause of atherosclerosis as atherosclerosis or related traits may accelerate the expansion of mutant hematopoietic clones Here we combine high-sensitivity DNA sequencing in blood and noninvasive vascular imaging to investigate the interplay between clonal hematopoiesis and atherosclerosis in a longitudinal cohort of healthy middle-aged individuals We found that the presence of a clonal hematopoiesis-related mutation confers an increased risk of developing de novo femoral atherosclerosis over a 6-year period whereas neither the presence nor the extent of atherosclerosis affects mutant cell expansion during this timeframe These findings indicate that clonal hematopoiesis unidirectionally promotes atherosclerosis which should help translate the growing understanding of this condition into strategies for the prevention of atherosclerotic cardiovascular disease in individuals exhibiting clonal hematopoiesis Such approaches would not be effective if the association between CH and atherosclerosis is merely due to the effects of atherosclerosis on the dynamics of CH a longitudinal cohort of healthy middle-aged individuals with serially collected blood DNA samples and deep cardiovascular and metabolic phenotyping including extensive imaging-based assessment of subclinical atherosclerosis burden in multiple vascular territories and at multiple time points we used a high-sensitivity sequencing approach to investigate CH and its dynamics in a longitudinal manner aiming to elucidate the interplay between CH and atherosclerosis We performed deep targeted sequencing to identify somatic mutations in a custom panel of 54 CH-related genes in 3,692 individuals from the PESA cohort The number of CH driver mutations identified per gene The values above the bars indicate the percentage of mutations affecting each specific gene The number of mutations per individual across quartiles of age The association between advancing age (stratified as quartiles) and CH (analyzed separately as driven by mutations in DNMT3A TET2 or other genes) based on multivariate logistic regression analyses adjusted for sex The bars indicate 95% confidence intervals centered in the mean value (square) The distribution of mutant clone size in the study population The dashed line shows the 2% VAF threshold most typically used to identify CH 50th (median) and 75th (Q3) percentiles of the data The whiskers represent Q1 − 1.5 × IQR at the minimum and Q3 + 1.5 × IQR at the maximum The prevalence of CH with VAF ≥2% across quartiles of age The association between gene-specific CH and female sex based on multivariate logistic regression analyses adjusted for age The CH prevalence across quartiles of age stratified by sex CH status in individuals carrying more than one mutation was defined on the basis of the mutation with the highest VAF We investigated the association between CH at baseline and de novo development of femoral atherosclerosis ∼3 years and ∼6 years after enrollment among PESA participants who initially lacked detectable atherosclerosis in this region 3DVUS imaging was used to determine the presence of femoral atherosclerosis Representative images from femoral atherosclerosis burden in an individual exhibiting de novo femoral atherosclerosis development (that is absence of detectable atherosclerosis at the baseline evaluation (left) and plaque development at follow-up (right); scale bar Incidence of de novo femoral atherosclerosis development at the 3-year follow-up (c n = 2,214) in individuals free of CH (no CH) and in individuals exhibiting CH with VAF 0.2–2% or ≥2% Incidence of de novo femoral atherosclerosis is also shown for myeloid CH (CHIP) or CH driven by specific CHIP genes Statistical significance in the analyses of CH and CHIP was evaluated using univariate logistic regression models (P for trends are shown) statistical significance was examined through proportion tests relative to the non-CHIP carriers group (*P < 0.05 The association between CH or CHIP and de novo femoral atherosclerosis development at the 3-year follow-up (e n = 2,214) based on multivariate logistic regression analyses lipid-lowering treatment and the AUC of SBP CACS and global atherosclerotic plaque volume assessed by 3DVUS imaging; the bars indicate 95% confidence intervals centered in the mean value (square) We monitored the expansion of 602 CH-related mutations through serial sequencing of blood samples from 494 individuals at baseline and ∼6 years after enrollment we investigated the association between subclinical atherosclerosis burden or related traits at baseline and the AER of the mutant hematopoietic clones The AER of mutations in any CH gene (n = 602) or specifically in DNMT3A (n = 381) compared with nondeleterious variants in CH-related genes (n = 271) Statistical significance was determined by two-sided Mann–Whitney–Wilcoxon tests (**P ≤ 0.01 The AER of CH-related mutations stratified by age quartiles (n = 602) AER of CH-related mutations stratified by sex (n = 602) The correlation between AER of CH-related mutations and baseline variant allele frequency (VAF) The P value for two-sided Pearson correlation is indicated The AER of CH-related mutations in individuals with no detectable atherosclerosis and across tertiles of plaque burden The AER of CH-related mutations stratified by conventional modifiable risk factors (j d and f–k was determined by mixed-effects models adjusted for baseline VAF (d) or sex and baseline VAF (c and f–k) The boxes in b–d and f–k represent the 25th (Q1) hindering the translation of research findings into new strategies for the prevention of CVD in CH mutation carriers our longitudinal assessment of the interplay between CH atherosclerosis and related traits provides important new insights into the relationship between CH and atherosclerosis we cannot rule out the possibility that clinically overt CVD (for example acute ischemic heart disease) modifies the dynamics of CH Although this possibility would not affect the primary conclusions of our study it deserves further investigation as it may help understand the regulation and effects of CH in high-risk CVD patients further studies are warranted to dissect the factors that determine the dynamics of CH and explore the underlying regulatory mechanisms As DNMT3A mutations are the most frequent mutations linked to CH these findings underscore the potential clinical significance of this condition Several limitations must be considered when interpreting our findings the study population consisted entirely of Caucasian individuals residing in Madrid which may limit the generalizability of our results to other racial and ethnic groups our findings related to the effects of CH on de novo femoral atherosclerosis cannot be directly extrapolated to other vascular beds; in this context future studies with other imaging modalities and in other age ranges are warranted CH in this middle-aged population was markedly dominated by DNMT3A mutations which limits our statistical power to assess the effects of CH driven by mutations in other genes; thus gene-specific analyses in this work should be considered exploratory our study was focused on examining the effects of atherosclerosis on the expansion of existing mutant hematopoietic clones; therefore we cannot draw any conclusions regarding the potential effects of atherosclerosis or related traits on de novo somatic mutagenesis which to our knowledge has not been postulated so far would require more sensitive sequencing techniques our study elucidates the directionality of the association between CH and atherosclerosis in humans These results provide critical new insight into the effects and regulation of CH which should help translate our growing knowledge of this condition into personalized strategies for managing the risk of atherosclerotic CVD and the presence of any disease expected to decrease life expectancy and any condition that could affect adherence to the study procedures The study protocol was approved by the Ethics Committee of Instituto de Salud Carlos III (CEI PI_52/2019) and all participants provided written informed consent de novo atherosclerosis development was defined as transitioning from absence of detectable atherosclerosis by 3DVUS at baseline to detectable atherosclerosis with plaque volume >0 mm3 at follow-up Limited sensitivity and statistical power precluded an accurate examination of the effects of CH on the progression of prevalent atherosclerotic plaques Modifiable risk factors and related traits were defined as continuous or categorical variables and evaluated on the basis of analyses of fasting blood samples and questionnaires Diabetes was defined as exhibiting plasma fasting glucose ≥126 mg dl−1 or being treated with insulin or hypoglycemic medication Hypertension was defined as exhibiting SBP ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg or being treated with antihypertensive medication Dyslipidemia was defined as exhibiting total cholesterol ≥240 mg dl−1 low-density lipoprotein cholesterol (LDL-C) ≥160 mg dl−1 or high-density lipoprotein cholesterol (HDL-C) <40 mg dl−1 or being treated with lipid-lowering drugs Obesity was defined as exhibiting a body mass index (BMI) ≥30 kg m−2 Low plasma HDL-C was defined as exhibiting plasma HDL-C <40 mg dl−1 in males or <50 mg dl−1 in females Hematological analyses included counts of leukocytes and main leukocyte subsets (neutrophils red blood cell distribution width and platelet counts blood samples from 223 individuals not carrying CH-related mutations at baseline were also sequenced ∼6 years after enrollment to estimate the expansion of nondeleterious somatic variants in CH-related genes as a surrogate of the expansion related to stochastic neutral drift We considered nondeleterious somatic variants those with impact ‘low’ (unlikely to change protein behavior synonymous variants) or ‘modifier‘ (typically noncoding variants) Likely germline variants and common sequencing artifacts were filtered out and only variants supported by reads on both the forward and reverse strands at both time points were included in the analysis consistent with our approach to investigate the expansion of CH driver variants the bioinformatic processing of sequencing data the curation of somatic variants to identify CH driver mutations and the statistical analysis of associations were conducted independently by different investigators who were blinded to other data Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article The present article includes all other data generated or analyzed during this study The code is publicly available and can be found via GitHub at https://github.com/Unidad-Bioinformatica-CNIC/CHIP-candidate_mutations. The source code from the R-packages used in this study are freely available online (https://cran.r-project.org/) Clonal hematopoiesis in human aging and disease Clonal hematopoiesis in cardiovascular disease and therapeutic implications Age-related clonal hematopoiesis associated with adverse outcomes Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis Common and rare variant associations with clonal haematopoiesis phenotypes A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasets Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease Association of clonal hematopoiesis with chronic obstructive pulmonary disease TET2-mutant clonal hematopoiesis and risk of gout Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence Supplemental association of clonal hematopoiesis with incident heart failure Interleukin-6 receptor polymorphism attenuates clonal hematopoiesis-mediated coronary artery disease risk among 451 180 individuals in the UK Biobank Clonal hematopoiesis of indeterminate potential and kidney function decline in the general population Clonal haematopoiesis and risk of chronic liver disease Somatic and germline variants and coronary heart disease in a Chinese population Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias Clonal haematopoiesis of indeterminate potential and atrial fibrillation: an East Asian cohort study Clonal hematopoiesis of indeterminate potential (CHIP) and incident type 2 diabetes risk Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis Sleep exerts lasting effects on hematopoietic stem cell function and diversity Clonal haematopoiesis and atherosclerosis: a chicken or egg question and coronary artery disease in postmenopausal women Impact of clonal hematopoiesis in patients with cardiogenic shock complicating acute myocardial infarction HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults Progression of Early Subclinical Atherosclerosis (PESA) study: JACC Focus Seminar 7/8 Inherited causes of clonal haematopoiesis in 97,691 whole genomes Clonal hematopoiesis is not prevalent in Hutchinson–Gilford progeria syndrome Clonal hematopoiesis and risk of progression of heart failure with reduced left ventricular ejection fraction Distinction of lymphoid and myeloid clonal hematopoiesis DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions Genetic interleukin 6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis Sex differences in the spectrum of clonal hematopoiesis Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia Subclinical atherosclerosis burden by 3D ultrasound in mid-life: the PESA study Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) study Femoral and carotid subclinical atherosclerosis association with risk factors and coronary calcium: the AWHS study Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects The longitudinal dynamics and natural history of clonal haematopoiesis Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population Cancer therapy shapes the fitness landscape of clonal hematopoiesis Cost-effective and scalable clonal hematopoiesis assay provides insight into clonal dynamics Bone marrow endothelial cells regulate myelopoiesis in diabetes mellitus Bone marrow activation in response to metabolic syndrome and early atherosclerosis Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis Failure to detect mutations in U2AF1 due to changes in the GRCh38 reference sequence Download references The PESA study is funded by the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) The project leading to these results received funding from ‘la Caixa’ Foundation under the project codes LCF/PR/HR17/52150007 and LCF/PR/HR22/52420011 This research work was also supported by grant PLEC2021-008194 funded by MICIU/AEI/10.13039/501100011033 and by ‘European Union NextGenerationEU/PRTR’; grant PID2021-126580OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU; and grant 202314-31 funded by MICIU/AEI/10.13039/501100011033’ and ‘ESF Investing in your future’ is supported by the European Commission (grant nos the Spanish Ministry of Science and Innovation (PID2022-140176OB-I00) and the Red Madrileña de Nanomedicina en Imagen Molecular-Comunidad de Madrid (P2022/BMD-7403 RENIM-CM) is supported by the program Atracción de Talento of the Comunidad de Madrid (GN:2022-T1/BMD-23767) funded by MICIN/AEI/10.13039/501100011033’ and ‘ESF Investing in your future’ The CNIC is supported by the Instituto de Salud Carlos III (ISCIII) Innovación y Universidades (MICIU) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033) Sanchez-González for his contribution to imaging analyses in PESA These authors contributed equally: Miriam Díez-Díez Centro Nacional de Investigaciones Cardiovasculares Ramos-Neble, Jorge de la Barrera, J Silla-Castro, Ana Quintas, Enrique Vázquez, M Ascensión Rey-Martín, Benedetta Izzi, Lucía Sánchez-García, Inés García-Lunar, Guiomar Mendieta, Virginia Mass, Nuria Gómez-López, Cristina Espadas, Gema González, Antonio J Quesada, Ana García-Álvarez, Antonio Fernández-Ortiz, Enrique Lara-Pezzi, Ana Dopazo, Fátima Sánchez-Cabo, Borja Ibáñez, Vicente Andrés, Valentín Fuster & José J Inés García-Lunar, Ana García-Álvarez, Antonio Fernández-Ortiz, Enrique Lara-Pezzi, Ana Dopazo, Fátima Sánchez-Cabo, Borja Ibáñez, Vicente Andrés & José J Guiomar Mendieta & Ana García-Álvarez Institut d’Investigacions Biomèdiques August Pi I Sunyer IIS-Fundación Jiménez Díaz University Hospital conducted association studies and contributed to writing the paper performed bioinformatics analyses of sequencing data supervised all bioinformatics and statistical analyses contributed to biological sample processing and revision contributed to the phenotyping of the PESA cohort and provided methodological input is the principal investigator of the PESA study supervised all analyses and wrote the paper All authors provided critical revision of the paper The authors declare no competing interests reviewer(s) for their contribution to the peer review of this work in collaboration with the Nature Medicine team Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We performed deep sequencing to identify somatic mutations in a custom panel of 54 CH-related genes in 3,692 middle-aged individuals from the PESA cohort CH-related genes included in the custom panel Genes for which a CH mutation was found in at least one individual are underlined and in bold font Genes typically considered as drivers of myeloid CH (frequently known as CHIP clonal hematopoiesis of indeterminate potential) or lymphoid-CH are shown separately Assay sensitivity for the detection of CH-related variants at different variant allele fractions (VAF) Dashed lines show the median sequencing depth of our study (3,712x; vertical line) and the sensitivity to detect CH variants at the minimum VAF threshold (0.2%) used to define CH (horizontal lines) Graphical representation of the CH-related genes found mutated in the study population; font size is proportional to the frequency of mutations Proportions of different type of mutations in CH-related genes according to their functional consequence Proportions of different types of single nucleotide substitutions TET2 (n = 153) and other sequenced genes (n = 362) The dashed line shows the 2% VAF threshold typically used to identify CHIP Whiskers represent Q1 - 1.5*IQR at the minimum and Q3 + 1.5*IQR at the maximum Proportion of CH-related variants identified after downsampling of sequencing depth to 30x “base” indicates the median sequencing depth for these variants using our original sequencing approach (3,625x); n = 168 CH variants Number of CH-related variants identified after downsampling to specific sequencing depths We performed deep targeted sequencing to identify somatic mutations in a custom panel of 54 CH-related genes in 3,692 middle-aged individuals from the PESA cohort CACS and 3DVUS imaging were used to determine subclinical atherosclerosis burden Graphs show the proportion of individuals with no detectable atherosclerosis and across tertiles of plaque burden n = 3,659) or femoral plaque volume by 3DVUS (d Statistical significance for differences in subclinical atherosclerosis burden was evaluated using an ordinal logistic regression model We investigated the association between CH at baseline and de novo development of femoral atherosclerosis ∼3-years after enrollment among individuals who initially lacked detectable atherosclerosis in that region assessed by 3-dimensional-vascular ultrasound (3DVUS) imaging Association between CH with VAF ≥ 2% and de novo atherosclerosis development in femoral arteries conventional modifiable risk factors as categorical variables and the cumulative systemic burden of atherosclerosis across the timeframe of the study (AUC for CACS Association between CH and de novo atherosclerosis development in femoral arteries and the cumulative systemic burden of atherosclerosis across the timeframe of the study (n = 2,353) Association between myeloid CH or CHIP with VAF ≥ 2% and de novo atherosclerosis development in femoral arteries conventional modifiable risk factors and the cumulative systemic burden of atherosclerosis across the timeframe of the study (n = 1,965) Association between CHIP and de novo atherosclerosis development in femoral arteries Bars in each panel indicate 95% confidence intervals centered in the mean value (square) scale bar: 2 mm) and 3D reconstruction (lower rows) from the right and left femoral arteries Images are representative of the upper limits of each tertile of atherosclerotic plaque volume legends for Supplementary Tables 2 and 7 (uploaded in an independent spreadsheet file) and Supplementary Figs CH-related mutations identified in the study population We performed deep targeted sequencing to identify somatic mutations in a custom panel of 54 CH-related genes in 3,692 individuals from the PESA cohort A total of 1,172 CH-related somatic variants were identified in 900 participants in PESA at baseline CH-related mutations identified longitudinally in the study population we found 602 CH variants in 494 individuals from the PESA cohort both at baseline and at the 6-year follow-up Download citation DOI: https://doi.org/10.1038/s41591-024-03213-1 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology IMG’s FC Diez Media is to sell media and sponsorship rights to Conmebol club competitions for a third successive cycle after retaining the business from 2027 to 2030 The club competitions that are part of the contract continue to include Conmebol’s showpiece events – the Copa Libertadores Copa Sudamericana and Recopa Sudamericana – as well as the likes of the Libertadores Femenina Libertadores Futsal and Libertadores Under-20 serves as a boost to IMG’s football division particularly after it was anticipated that Conmebol was looking to issue a competitive request for proposal The sales agreement does not include the management of broadcast production services which were all taken in house by Conmebol ahead of the 2023-26 cycle FC Diez Media was set up as a joint venture between IMG and Perform but the latter’s 50-per-cent shareholding was bought by IMG five years ago for $37m Conmebol and IMG said that they have delivered a 43-per-cent revenue increase from 2019-22 to 2023-26 “Their successful track record continued in 2024 a total of $468.2m was raised from commercial rights sales to the various Conmebol club competitions described the association with IMG as a success for the growth of South American football through “alliances with world-renowned brands and record numbers in reach and audience” broadcast rights to the men’s club competitions have been distributed in over 190 countries Free live streaming on Canal Goat and Pluto TV has helped to generate more exposure for the Conmebol Libertadores Femenina IMG’s senior-vice president and managing director told SportBusiness: “We’re currently working with Conmebol on our go-to-market strategy for the 2027-30 cycle and we see strong growth potential domestically and internationally for traditional live broadcast rights “We are building on incredibly strong momentum for South America’s most premium rights and we are also seeing great interest from other buyers.” Klein also highlighted the hosting of the 2026 Fifa World Cup by USA along with this year’s 65th anniversary of the Copa Libertadores A total of 10 top-tier Official Sponsors of the Copa Libertadores have been brought in for the 2023-26 cycle These are: Amstel; Bwin; Coca-Cola; Crypto.com; EA Sports; Hyundai; Mapfre; Mastercard; Mercardo Libre; and TCL the Unilever-owned antiperspirant and deodorant brand was recently signed as the fifth second-tier Official Partner News of the Conmebol renewal comes a week after IMG’s takeover by TKO Group Holdings was finalised ©2025 SBG Companies Limited or its affiliated companies Application for the appointment of a Commissioner to collect evidence from Pershing LLC – pursuant to a request for judicial assistance from Argentina – for a criminal investigation into “Mariano Bautista Diez and others for bribery and intentional alteration of public administration records” we and our partners use technologies like cookies to store and/or access device information Consenting to these technologies will allow us and our partners to process personal data such as browsing behavior or unique IDs on this site and show (non-) personalized ads may adversely affect certain features and functions Click below to consent to the above or make granular choices. Your choices will be applied to this site only. You can change your settings at any time or by clicking on the manage consent button at the bottom of the screen Please select all the ways you would like to hear from Osteen Publishing Company: You can unsubscribe at any time by clicking the link in the footer of our emails For information about our privacy 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You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email READ MONOGRAPH Chequers has announced the appointment of Alejandro Díez-Barturen as a new partner and head of Corporate Díez-Barturen brings extensive expertise in corporate transactions and legal advisory services to the firm A Law graduate from the University of Zaragoza he furthered his legal education with an LL.M in Business Law (MAJ) from IE Business School and an LL.M His professional career includes working as a senior lawyer at Ontier and serving as Legal Director for M&A and Business Development at Parques Reunidos one of the world’s leading leisure and entertainment companies His addition to Chequers strengthens the firm’s corporate and M&A practice reinforcing its ability to provide high-level legal counsel in complex business transactions Juan Pelegrí y Girón joins Garrido Commercial Law… European CLOs face higher investigation costs It represents the main source of information in the legal business sector in Spain and Portugal The digital magazine – and its portal – address to the protagonists of law firms and in-house lawyers The magazine is available for free on the website and on Google Play and App Store information about deals and their advisors For further information, please visit the Group’s website www.lcpublishinggroup.com *This interview has been edited for length and clarity and was formerly a senior lecturer at the Asian Center of the University of the Philippines York: What does free expression mean to you free speech or free expression means the exercise of the right to express oneself and to seek and receive information as an individual or an organization so it means the ability to express thoughts or opinions without threats or intimidation or fear of reprisals Free speech is expressed in various avenues such as in a community where one lives or in an organization where one belongs at the national and policy decisions; giving education; addressing historical revisionism—which is historically common in my country Without freedom of speech people will be kept in the dark in terms of access to information in understanding and analyzing information and deciding which information to believe and which information is incorrect or inaccurate or is meant to misinform people So without freedom of speech people cannot exercise their other basic human rights religious organizations who are preaching will not be able to fulfill their mission of preaching if freedom of speech is curtailed I have worked for years with families of the disappeared—victims of enforced disappearance—in many countries And this forced disappearance is a consequence of the absence of free speech These disappeared people are forcibly disappeared because of their political beliefs And they were deprived of the right to speech in the Philippines and many other Asian countries and demonstrations on various legitimate issues of the people are being dispersed by security forces in the name of peace That’s depriving legitimate protesters from the rights to speech and to peaceful assembly So these people are named as enemies of the state So allowing these people to exercise their constitutional rights is a manifestation of free speech But in many Asian countries—and many other countries in other regions also—such rights Free speech in whatever country you are in is freedom to study the situation of that country to give your opinion of that situation and share your ideas with others York: Can you share some experiences that helped shape your views on freedom of expression During my childhood years, when martial law was imposed, I’d heard a lot of news about detention, arrest and detention of journalists because of their protest against martial law that was imposed by the dictator Ferdinand Marcos, Sr who was the father of the present President of the Philippines So I read a lot about violations of human rights of activists from different sectors of society Because they spoke against the Marcos administration this actually formed my mind and also my commitment to freedom of expression So free speech means freedom without thread And it means being able to use all avenues in various contexts to speak in whatever forms—verbal speeches the enforced disappearance of my husband informed my views on free expression Two weeks after we got married he was briefly forcibly disappeared and he was forced to confess that he was a member of the Communist Party of the Philippines He was together with one other person he did not know and did not see and they were forced to dig a grave for themselves to be buried alive inside Another person who was disappeared then escaped and informed us of where my husband was So we told the military that we knew where my husband was They were afraid that the other person might testify so they released my husband in a cemetery near his parent’s house that’s why I work a lot with families of enforced disappearances both in the Philippines and in many other countries I believe that the experience of enforced disappearance of my husband and other family members of the disappeared and their experience of having family members disappeared until now is a consequence of the violation of freedom of expression And also my integration or immersion with families of the disappeared has contributed a lot to my commitment to human rights and free speech of being grateful for the experience we had—because they are very rare cases where victims of enforced disappearances surfaced alive—so I dedicate my whole life to the cause of human rights York: What do you feel are some of the qualities that make you passionate about protecting free expression for others we were taught about the importance of speaking for the truth It was also because of our religious background We were taught it is very important to tell the truth So this passion for truth and uprightness is one of the qualities that make me passionate about free expression And the sense of moral responsibility to rectify wrongs that are being committed I love writing whenever I have the opportunity to do it And the sense of duty to make human rights a lifetime commitment York: What should we know about the role of social media in modern Philippine society I believe social media contributed a lot to what we are now. The current oppressive administration invested a lot in misinformation and that’s why a lot of young people think of martial law as the years of glory and prosperity I believe one of the biggest factors of the administration getting the votes was their investment in social media for at least a decade York: What are your feelings on how online speech should be regulated And the study scope is limited as it only covered posts and comments in Burmese The researchers involved also reported that many other posts were reported and subsequently removed prior to being documented So the actual amount of hate speech is likely to be significantly higher So while FORUM-Asia acknowledges the efforts of Facebook to promote policies to curb hate speech on the platform it still needs to update and constantly review all these things including those on political advertisements and paid or sponsored content with the participation of the Facebook Oversight Board York: Can you tell me about a personal experience you’ve had with censorship an experience you have of using freedom of expression for the greater good In terms of censorship, I don’t have personal experience with censorship. I wrote some opinion pieces in the Union of Catholic Asian News and other online platforms, but I haven’t had any experience of censorship. Although I did experience negative comments because of the content of what I wrote. There are a lot of trolls in the Philippines and they were and are very supportive of the previous administration of Duterte so there was negative feedback when I wrote a lot on the war on drugs and the killings and impunity I believe we have so many unsung heroes in terms of free speech and these are the unknown persecuted human rights defenders But I also answer that during this week we are commemorating the Holy Week [editor’s note: this interview took place on March 28 2024] so I would like to say that I would like to remember Jesus Christ and resurrection Christians are commemorating this week he was enraged when he witnessed how defenseless poor were violated of their rights and he was angry when authority took advantage of them Also, in contemporary times, Óscar Arnulfo Romero y Galdámez I consider him as my free speech hero also I visited the chapel where he was assassinated celebrated the 44th anniversary of his assassination last Sunday the 24th of March the consequent persecution of the progressive segment of the Catholic church and the churches in El Salvador and the indiscriminate killings of the Salvadoran people in his communities San Romero courageously spoke on the eve of his assassination “I would like to make a special appeal to the men of the army and specifically to the ranks of the National Guard You are killing your own brother peasants when any human order to kill must be subordinate to the law of God which says ‘Thou shalt not kill.’ No soldier is obliged to obey an order contrary to the law of God It is high time you recovered your consciences and obeyed your consciences rather than a sinful order cannot remain silent before such an abomination We want the government to face the fact that reforms are valueless if they are to be carried out at the cost of so much blood in the name of this suffering people whose cries rise to heaven more loudly each day I order you in the name of God: stop the repression.” So as a fitting tribute to Saint Romero of the Americas the United Nations has dedicated the 24th of March as the International Day for Truth Jesus Christ being the most courageous human rights defender during these times Which I’m sure was the model of Monsignor Romero SAN FRANCISCO – The Trump Administration must cease its politically motivated investigation of former U.S Cybersecurity and Infrastructure Security Agency Director Christopher Krebs the Electronic Frontier Foundation (EFF) and dozens hundreds (see update below) of prominent cybersecurity and election security experts urged in an open letter Once again, the Texas legislature is coming after the most common method of safe and effective abortion today—medication abortion.Senate Bill (S.B.) 2880* seeks to prevent the sale and distribution of abortion pills—but it doesn’t stop there By restricting access to certain information online It has now been nearly two months since UK Prime Minister Starmer spoke with Egyptian President Abdel Fattah el-Sisi, yet there has been no tangible progress in the case of Alaa Abd El Fattah, the British-Egyptian writer, activist, and technologist who remains imprisoned in Egypt.In yet another blow.. This is the first part of a three-part series about age verification in the European Union. In this blog post, we give an overview of the political debate around age verification and explore the age verification proposal introduced by the European Commission, based on digital identities. Part two takes.. Update 4/25/25: EFF joined the ACLU and other legal advocacy organizations today in filing an additional amicus brief in support of the law firm Susman Godfrey LLP which also has been targeted by President Donald Trump.Update 4/11/25: EFF joined the ACLU and other legal advocacy organizations.. Cybersecurity professionals and the infosec community have essential roles to play in protecting our democracy and safeguarding government infrastructure It is critically important for us to speak up to ensure that essential work continues and that those engaged in these good faith efforts are.. In January, Meta made targeted changes to its hateful conduct policy that would allow dehumanizing statements to be made about certain vulnerable groups Meta’s hateful conduct policy now contains the following text:People sometimes use sex- or gender-exclusive language when discussing access to spaces often limited by sex.. Check out our 4-star rating on Charity Navigator Garrigues has hired Ignacio Díez-Picazo as of counsel in the Dispute Resolution: Litigation and Arbitration where he will bring his extensive experience as a lawyer in complex civil and commercial litigation as well as in domestic and international arbitration Following stints at several international firms in recent years Ignacio has practiced as managing partner of his own family firm founded by his father Luis Díez-Picazo and specialized in civil and commercial dispute resolution.In his professional practice Ignacio has acted as counsel for some of the leading Spanish and foreign companies in the financial and service sectors.He is professor of Procedural Law at Universidad Complutense de Madrid a member on leave from the Legal Service of the Constitutional Court permanent member of Procedural Law Panel Five of the General Codification Committee of the Ministry of Justice corresponding member of the Procedural Law Panel of the Spanish Royal Academy of Jurisprudence and Legislation member of the Spanish and Ibero-American Arbitration Club member of the FIDE Academic Council; as well as Chairman of the Spanish Business Litigation Club He has also authored numerous publications on procedural law and sits on the editorial boards of several prestigious periodicals Garrigues has a team of over 200 experts in litigation (civil with expertise in resolving all types of business disputes new director of Fraternidad-Muprespa’s counseling and… STOCKHOLM — December 13 2024 — Circulose is proud to announce the appointment of Sara Diez Jauregui and Kalyan Madabhushi to further strengthen its Board of Directors following the recent appointment of Chair Helena Helmersson These additions bring world-class expertise across the value chain: Diez Jauregui offers extensive experience with leading fashion and apparel brands while Madabhushi brings a notable career at Aditya Birla Group a global leader in cellulosic fiber production With their expertise in fashion and sustainability Sara and Madabhushi join the Circulose team at a pivotal moment Sara brings a profound understanding of the industry and commitment to sustainability with a leading background in fashion “I am deeply honored to join the board of Circulose and grateful to Altor and the CEO Jonatan Janmark for this incredible opportunity Being part of a board with such talented professionals is both exciting and inspiring I look forward to collaborating with the Circulose team to advance the mission of making fashion circular the norm not the exception,” said Diez Jauregui Madabhushi’s expertise in the fiber and pulp industries coupled with his strong leadership in driving circularity across global value chains makes him an ideal addition to Circulose’s Board of Directors “I am delighted to join the board alongside Sara and under the leadership of Helena Circulose’s combination of a strong owner like Altor and a commitment to learnings from past challenges is a recipe for success A lot of great progress has already been achieved and I am confident that Circulose is well-positioned to deliver measurable impact for our partners and customers we will continue to ensure Circulose’s role as a transformative force in the textile industry.” commented Madabhushi Sara Diez Jauregui is a leader and strategic advisor with over 20 years of executive experience in the fashion Sara has built a distinguished career working with some of the leading companies such as Zara (Inditex) Currently serving as the CEO of The Post Fiber she is at the forefront of driving sustainable innovation in fashion she serves on the Board of Directors of Revolution Race advocating for responsible practices and transformative change in the sector Kalyan Ram Madabhushi is a highly experienced CEO and Board Director with over 34 years of leadership in global businesses across diverse regions Having held senior roles at Royal Dutch Shell and Aditya Birla Group (ABG) Kalyan has led transformation initiatives in the chemicals He has served on multiple boards of international joint ventures and brings a strategic Kalyan holds an MBA in International Business and a Bachelor’s in Mechanical Engineering in addition to completing executive programs at IMD Switzerland and the University of Oxford United Arab Emirates: The Dubai Integrated Economic Zones Authority (DIEZ) has announced that over 700 companies specializing in artificial intelligence and its applications are now operating within its three economic zones This milestone underscores the effectiveness of DIEZ’s AI strategy which focuses on future-readiness and accelerating the adoption of AI technologies The announcement was made during Dubai AI Week Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum Deputy Prime Minister and Minister of Defence of the UAE and Chairman of The Executive Council of Dubai The event was organized by the Dubai Center for Artificial Intelligence and hosted at the Museum of the Future and Area 2071 at Emirates Towers ranging from startups and small and medium enterprises to multinational corporations and offer a wide array of specialized services in artificial intelligence Many of these companies are also focused on developing AI-related technologies and applications aligning with DIEZ’s strategic objectives in this space and reinforcing its role in advancing the UAE National Strategy for Artificial Intelligence 2031 and the Dubai Universal Blueprint for Artificial Intelligence designed to accelerate the adoption of AI applications " The artificial intelligence strategy adopted by DIEZ reflects the vision of His Highness Sheikh Mohammed bin Rashid Al Maktoum Vice President and Prime Minister of the UAE and Ruler of Dubai which aims to solidify the UAE’s global leadership in AI and create agile and smart business environments that enhance the competitiveness of the national economy." “The success of this strategy is reflected in the growth of AI-focused companies within DIEZ’s economic free zones underscoring our commitment to leading in this space by staying ahead of change and leveraging advanced technologies across all areas of operation This reaffirms that artificial intelligence today stands as a foundational pillar in Dubai’s economic transformation journey ensuring long-term sustainability and growth.” DIEZ’s Artificial Intelligence Strategy is built around three core pillars that form the foundation of its smart transformation efforts: people These pillars aim to empower human capital through AI tools by enhancing skills and productivity as part of the first pillar; elevate customer experience through smart data-driven solutions under the second pillar; and establish advanced digital infrastructure to ensure quality and the effective and sustainable deployment of AI models through the third pillar DIEZ seeks to drive tangible improvements in organizational performance and solidify its position as a key player in Dubai’s digital transformation aligned with the emirate’s vision of building a knowledge-based The strategy comprises 12 high-impact initiatives covering a broad range of critical AI applications along with several innovative use cases that support decision-making and the development of digital infrastructure across all DIEZ free zones The ongoing projects include the development of an AI-powered tool for reviewing and auditing documents related to daily operations and company formation a specialized cybersecurity solution to address risks and cyberattacks as well as platforms for handling customer complaints and requests The press release is provided for informational purposes only legal or investment advice or opinion regarding the suitability value or profitability of any particular security Neither this website nor our affiliates shall be liable for any errors or inaccuracies in the content or for any actions taken by you in reliance thereon You expressly agree that your use of the information within this article is at your sole risk To the fullest extent permitted by applicable law its affiliates and the respective shareholders content providers and licensors will not be liable (jointly or severally) to you for any direct even if the parties have been advised of the possibility or could have foreseen any such damages Get insights and exclusive content from the world of business and finance that you can trust Casa el Pastizal, designed by the architecture studio Diez + Muller, is a contemporary residence nested in the vast landscape of Machachi, Ecuador The design approach emphasizes a harmonious relationship between the house and its natural surroundings blending modern architecture with the inherent beauty of the Andean region The architects of Casa el Pastizal adopt an intuitive design process that emphasizes the connection between the built environment and nature the house’s fragmented volume is embedded into the landscape Rather than imposing itself on the terrain either sinking gently into the earth or rising and rotating to capture distant views This careful manipulation of the topography allows the structure to merge with the environment while preserving the natural qualities of the site The overall concept prioritizes a balanced dialogue between the existing landscape and the proposed architecture images © JAG Studio Designing Casa el Pastizal, the architects at Diez + Muller position the entrance along a lower point on the land where a lateral ascent leads visitors toward the house the vertical elements of the structure come into view The journey to the house is a dynamic experience where movement and observation of the vast surrounding landscape unfold naturally The dwelling’s design places emphasis on the passage between spaces creating an emotional journey that invites contemplation of the landscape from different vantage points One of the greatest challenges of this vast site is ensuring that the user’s experience remains intimate and grounded creating a sense of enclosure that prepares the visitor for entry into the home Casa el Pastizal integrates subtly into the natural landscape In addition to its connection with the surrounding environment Casa el Pastizal is designed by Diez + Muller as a retreat into the interior The architecture provides spaces for quiet contemplation where residents can disconnect from the everyday The circulation through the house mirrors the experience of the external landscape — inviting pauses and moments of reflection As light and shadow play across the surfaces the rough textures and imperfections of the materials are revealed These details highlight the beauty in simplicity and they serve as a reminder of the subtle forces that shape the daily rhythm of life either sinking into the earth or rising to capture distant views The materiality and construction systems of Casa el Pastizal are chosen for their ability to adapt to the specific challenges of the site responding to the unpredictable conditions of the Andean equatorial climate at 3,200 meters above sea level elevated beams that span up to twelve meters allowing the structure to bear significant weight while integrating large volumes of earth on its slabs This feature enables the creation of green areas atop the house fostering vegetation that further connects the architecture to the land The relationship between the interior and exterior spaces is defined by large open areas that blur the line between inside and outside creating a spatial fluidity that contrasts with the solid mass of the concrete structure the approach to the house is a dynamic journey that reveals the architecture gradually patios and viewpoints create an intimate connection with the vast surrounding landscape load-bearing walls and beams support large spans the construction uses durable materials to withstand the Andean equatorial climate the house offers spaces for retreat and contemplation architect: Diez + Muller | @diezmuller photography: © JAG Studio | @juanalbertoandrade.ec AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style Independence Day is just around the corner — Mexican Independence Day commemorates the start of an insurrection that eventually led to Mexico’s freedom from Spanish rule Remember to check the websites or social media on each event for any last-minute changes. You can find more events at Go See DFW VIVA DALLAS The City of Dallas launches Hispanic Heritage Month in front of Dallas City Hall with a festival Mexican street food and mariachis and bands on the main stage The event also includes a community procession at 6 p.m that ends with the official Grito at 7 p.m Grito means "shout” in Spanish and is an expression that sounds a lot like a yodel Its re-creation commemorates the call to arms by Catholic priest Miguel Hidalgo on September 16 which started the Mexican War of Independence Details: Sept  DALLAS ARBORETUM HISPANIC HERITAGE CELEBRATION Don't miss the 7th annual Hispanic Heritage Celebration at the Dallas Arboretum this weekend The event features dance and musical performances cooking demonstrations and the always popular Quinceañera fashion show Details: Sept ¡CELEBRAMOS! AT THE FORT WORTH BOTANIC GARDEN  The Fort Worth Botanic Garden invites guests to celebrate Latin American culture with six-week event that includes performances and exhibitions 14 with a Latin American flag parade and free admission The day also includes live music by an all-female mariachi trio Details: Sept 14-Oct.27 at the Fort Worth Botanic Garden DIECISEIS CELEBRATION AT THE PARK FOREST LIBRARY Stop by the Park Forest Branch of the Dallas Public Library for a celebration that includes music dancing from the Allegre Ballet Foklorico and a Grito reenactment  Details: Sept at the Park Forest Branch of the Dallas Public Library dallaslibrary.librarymarket.com/event/dieciseis-celebration-mexican-independence-day-353241  MEXICAN INDEPENDENCE DAY CELEBRATION AND FUN WALK The Lakefront in Little Elm hosts a Mexican Independence Day party that includes carnival rides Ballet Folklorico and music from the Selena Forever Tribute Band don’t miss the Tacos & Tequila Fun Walk performers and even a beer burro while you’re led through the trails in Little Elm Park by a mariachi band Each walker receives four food tastings and four margarita drinks Non-alcoholic tickets are also available.  Details: Sept FESTIVAL INDEPENDECIA FIESTAS PATRIAS IRVING Celebrate Mexican and Central American Independence Day with food activities for the whole family and a live music line-up that includes Alexandra La Reina de la Bachata Details: Sept  FIESTAS PATRIAS IN FORT WORTH the Mexican consul general of Dallas takes the stage at La Gran Plaza de Fort Worth to give the Grito de Independencia The day-long festival also includes live music and ballet folklorico performances Details: Sept DUNCANVILLE MEXICAN INDEPENDENCE DAY CELEBRATION The City of Duncanville celebrates Mexico's independence from Spain with an El Grito with the Mexican Consulate and a day filled with music Details: Sept The Go See DFW calendar is a partnership between KERA and The Dallas Morning News Arts Access is an arts journalism collaboration powered by The Dallas Morning News and KERA This community-funded journalism initiative is funded by the Better Together Fund Jennifer & Peter Altabef and The Meadows Foundation The News and KERA retain full editorial control of Arts Access’ journalism LAS CRUCES - There's a reason why the Town of Mesilla celebrates Diez y Seis de Septiembre every year — a holiday that commemorates Mexican Independence Day — and that's because the historic and charming village used to be a central meeting point for both Spaniards and Mexicans Diez y Seis de Septiembre marks the launch of Mexico’s struggle for independence from Spain Miguel Hidalgo de Costilla led the first large revolutionary forces against the Spaniards The holiday is similar to July 4 in the United States The Town of Mesilla will host its annual Diez y Seis de Septiembre celebration Saturday Mesilla is staked in tradition and it is one of the first towns in the area," said Dorothy Sellers "We're holding onto the tradition and celebrating our roots We will have everything from Mariachis ballet folklorico dancers and vendors selling everything from homemade arts and crafts food and beverages We will also have a jumping balloon and a greased pole climb for the kids." Florida and parts of Oklahoma and Cuba As a result of the Mexican War and the Treaty of Guadalupe Hidalgo Mesilla was within the strip of land claimed by both the United States and Mexico made the land deal to establish a southern railroad route to California — declared Mesilla officially part of the United States. As Mesilla was the most important community in this parcel the treaty was consummated by the raising of the American flag on the town plaza with much ceremony on Nov Sellers said Mesilla’s annual celebration will kick off with a parade at 10 a.m. Saturday The parade route begins at the corner of Avenida de Mesilla and Calle de Mercado and the route ends at Four Points Gin This year’s theme is The Town of Mesilla.  "I will still be taking entries through Wednesday Opening ceremonies for the fiesta will be held from noon to 10 p.m Mayor Nora Barraza will begin with a welcome message and the traditional "El Grito" will be performed by Adriana Martinez, deputy consul of community affairs for the general of Mexico Joel Martinez will serve as the master of ceremonies Saturday evening will conclude with Latin band Nosotros and Sunday will conclude with the band Tudy and the Silver Bullet Band from 4  to 7 p.m About 30 vendor booths will line the plaza offering a variety of products including art sponsored by Andele Restaurant and piñatas for kids Sept. 1512 noon Welcome by Mayor Nora BarrazaNational Anthem by Sarah Montiel12 noon Ballet Folklorico Angeles del Valle12:30 p.m Mariachi Estrellitas1:30 p.m. Ballet Folklorico Diamantes del Valle2 p.m Ballet Folklorico Diamantes de Valle with Mariachi Alma de Jalisco3:30 p.m Piñata and greased pole climb Sponsored by Andele’s Restaurant4 p.m smoking and pets are not allowed on the plaza call the Town of Mesilla at 575-524-3262 ext Jacqueline Devine can be reached at 575-541-5476, JDevine@lcsun-news.com or @JackieIsDevine on Twitter More: Sears store at Mesilla Valley Mall among 100 locations set to close this year More: Las Cruces school board hears data on testing, graduation rates The identification of patients with chronic hypoparathyroidism who are adequately (AC) or not adequately controlled (NAC) has clinical interest, since poor disease control is related to complications and mortality. We aimed to assess the prevalence of NAC patients in a cohort of subjects with postsurgical hypoparathyroidism. The present study shows a strikingly high prevalence of NAC patients in the clinical practice of Spanish endocrinologists. Results suggest that NAC disease might be associated with some prevalent and incident comorbidities. Volume 15 - 2024 | https://doi.org/10.3389/fendo.2024.1464515 Purpose: The identification of patients with chronic hypoparathyroidism who are adequately (AC) or not adequately controlled (NAC) has clinical interest since poor disease control is related to complications and mortality We aimed to assess the prevalence of NAC patients in a cohort of subjects with postsurgical hypoparathyroidism cohort study including patients from 16 Spanish hospitals with chronic hypoparathyroidism lasting ≥3 years We analyzed disease control including biochemical profile and clinical wellness For biochemical assessment we considered three criteria: criterion 1 phosphorus and calcium x phosphorus product; criterion 2 the above plus estimated glomerular filtration rate ≥60 ml/min/1.73 m2; and criterion 3 the above plus normal 24-hour urinary calcium excretion A patient was considered AC if he or she met the biochemical criteria and was clinically well Results: We included 337 patients with postsurgical hypoparathyroidism (84.3% women median time of follow-up 8.9[6.0-13.0] years) The proportions of NAC patients with criteria 1 Patients who had dyslipidemia at the time of diagnosis presented a significantly higher risk of NAC disease (criterion 3; OR 7.05[1.44-34.45]; P=0.016) NAC patients (criterion 2) had a higher proportion of subjects with incident chronic kidney disease and eye disorders and NAC patients (criterion 3) had a higher proportion of incident chronic kidney disease nephrolithiasis and dyslipidemia than AC patients Conclusion: The present study shows a strikingly high prevalence of NAC patients in the clinical practice of Spanish endocrinologists Results suggest that NAC disease might be associated with some prevalent and incident comorbidities In the present report we aimed to assess the proportion of NAC patients in this national cohort of patients using different disease control criteria as well as their possible relationships with complications and comorbidities This study analyzes the clinical and biochemical situation at the end of follow-up in a previously described cohort of patients with chronic hypoparathyroidism after thyroidectomy (5) patients included were over 18 years of age at the time of thyroidectomy and had a follow-up period in the same hospital ≥3 years carried out under the auspices of the Thyroid Task Force of the Spanish Society of Endocrinology and Nutrition (SEEN) Twenty investigators from 16 hospital centers agreed to participate in the study A review of the medical records of all patients who met the inclusion criteria was performed Each investigator collected information on clinical and demographic data as well as the clinical situation and biochemical profile at the last visit For the purposes of the present study, each investigator evaluated the adequacy or inadequacy of the treatment of hypoparathyroidism in their patients. For this, we used the matrix reported by Iqbal et al. (13) modified and simplified one that assesses biochemical values ​​and another that assesses the patient’s well-being Given that the variables used are considered dichotomous (normal or abnormal biochemical values; the patient is well or not well) four groups can be defined based on the normality or abnormality of the biochemical tests and the patient’s well-being: group 1 patients with normal biochemistry who feel well; group 2 patients with abnormal biochemistry who feel well; group 3 patients with normal biochemistry who feel unwell; and group 4 patients with abnormal biochemistry who feel unwell patient well-being was based on the intensity of symptoms related to hypoparathyroidism complications of chronic hypoparathyroidism and also other comorbidities or concomitant diseases Clinicians were required to make a holistic assessment of the patient’s health status If the clinician believed that any of these symptoms substantially affected the patient’s quality of life and that not all patients had all the biochemical data available at last visit three criteria with different levels of demand were used for biochemical classification of patients into normal or abnormal: criterion 1 serum Ca concentrations between 8.0 and 10.5 mg/dl serum P concentrations between 2.5 and 4.5 mg/dl and CaxP product <55 mg2/dl2; criterion 2: normal Ca and P according to the previous criteria and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2; and criterion 3: the same as in criterion 2 together with a normal 24-hour urinary calcium excretion (<250 mg/24h in females and <300 mg/24h in males) A patient was considered to be AC when he or she was in group 1 of the matrix Given that in this study three biochemical criteria with different degrees of demand were used the proportions of NAC patients with lax (criterion 1) intermediate (criterion 2) and demanding (criterion 3) criteria were quantified All patient’s data were obtained under the standard medical care conditions Analytical determinations were performed using routine techniques in the biochemistry laboratories of the participating centers The Ca values ​​considered in this study refer to serum calcium corrected by albumin or total proteins The eGFR was calculated by the usual method in each of the participating hospitals (CDK-EPI equation in 60% of the subjects The patient’s confidential information was protected according to national law and the study received favorable report from the ethics committee of the Hospital Universitario Puerta de Hierro Majadahonda (PI 253/22) the boards of directors of SEEN approved the study results are expressed as median (interquartile range Categorical variables are described as absolute values the chi-square test or Fisher’s exact test was used For comparisons of means between two groups of subjects the Mann–Whitney U-test was employed Several univariate and multivariable logistic regression models were used to explore the factors determining the inadequacy of disease control and therapeutic data were included as explanatory variables in these models Multivariable model 1 was adjusted for prevalent comorbidities at the time of diagnosis of hypoparathyroidism; model 2 was adjusted for the same covariates All used tests were two-sided and differences were considered significant when P < 0.05 The studied cohort consisted of 337 patients (84.3% women The cause of thyroidectomy was thyroid cancer in 255 patients (66.8%) and benign thyroid disease in the rest All patients were treated by conventional therapy of chronic hypoparathyroidism with orally administered calcium (n=296; median dose 1.25[1-2] g/day) and calcitriol (n=332; 0.50[0.25-0.50] μg/day) Table 1 shows the biochemical data at the end of follow-up with an indication of the number of patients in which each parameter was available 83.6% (249 out of 298) and 64.9% (211 out of 325) of patients had normal serum Ca and P levels Two hundred and seventy one out of 306 patients (88.6%) showed an eGFR greater than 60 ml/min/1.73m2 Normal calciuria was obtained in 85 of 123 women (69.1%) and in 27 of 29 men (93.1%) with this parameter available Characteristics of patients with chronic hypoparathyroidism and assessment of the biochemical and clinical normality criteria at the end of the follow-up period normality for the biochemical criteria was obtained in a proportion of patients that decreased as the requirement of the criterion increased: 165 of 286 patients (57.7%) for criterion 1 The doctors’ assessment of the general clinical situation at the end of follow-up showed a normal result in 289 of 334 (85.0%) patients The number of patients with available data that we used to draw the three matrices and calculate the proportion of NAC patients according to the three criteria is shown in Figure 1. The matrices displaying the disease control assessment, including the absolute values ​​and percentages of patients in the four groups, are shown in Figure 2 the proportion of AC patients (group 1) was clearly higher in matrix 1 (153/283; 54.1%) compared to matrix 3 (41/111; 36.9%) The opposite was seen in the case of group 4 patients with poor biochemical and clinical control (31/283; 11.0% in matrix 1 vs Flow diagram indicating the sample sizes of each group of patients with availability of clinical and biochemical data according to the three control criteria used in the study Patient classification matrices according to biochemical levels and the clinical assessment at the end of follow-up The data are the absolute number and percentage of patients in each group or subgroup Each panel represents one of the biochemical criteria: (A) group 1 (normal biochemical levels/well); G2 group 2 (abnormal biochemical levels/well); G3 group 3 (normal biochemical levels/unwell); G4 group 4 (abnormal biochemical levels/unwell) To assess the relationship between disease control and demographic and clinical data at the time of diagnosis, the values found at diagnosis in AC and NAC patients were compared based on the three control criteria (Table 2) between disease control at the end of follow-up and gender time of evolution or histology of the surgical specimen there were no differences between AC and NAC patients when criterion 1 was applied in any of the studied prevalent comorbidities NAC patients had a significant higher prevalence at the time of diagnosis of chronic kidney disease the difference was only significant for the prevalence of dyslipidemia Relationship between disease control at the end of follow-up and demographic and clinical characteristics and prevalent diseases at the time of diagnosis of hypoparathyroidism Several models of logistic regression analysis were performed to study the dependence of the variable inadequate disease control as a function of several independent variables (Supplementary Material; Supplementary Tables S1-S3) none of the studied variables were significant in multivariable models patients who had dyslipidemia at the time of diagnosis presented a significantly higher risk of inadequate control of hypoparathyroidism in both univariable (OR 7.80[1.72-35.40]; P=0.008) and multivariable models (OR 7.05[1.44-34.45]; P=0.016) Table 3 shows the proportion of patients who presented incident comorbidities throughout follow-up in subjects classified according to their degree of control and according to the criteria for evaluating disease control There were no differences in the incidence of comorbidities when criterion 1 was applied we observed that NAC patients had a higher proportion of subjects with incident chronic kidney disease and eye disorders than those found in AC patients NAC patients with criterion 3 exhibited a higher proportion of incident chronic kidney disease Incident comorbidities in patients classified according to the degree of adequacy of hypoparathyroidism control at the last visit Results of this study provide two clinically relevant novelties in the field of care for patients with hypoparathyroidism our data reveal a strikingly high proportion of patients with poor control of the disease almost half of the patients with chronic hypoparathyroidism in the clinical practice of Spanish endocrinologists are poorly controlled at the time of diagnosis of hypoparathyroidism and cardiovascular disease have a greater tendency toward poor disease control with the intermediate criterion only dyslipidemia is associated with poor disease control when the strictest biochemical criterion is applied (criterion 3) The interpretation of these results requires considering the distinct criteria used in our analysis The difference between criterion 1 and criterion 2 is the requirement of an eGFR ≥60 ml/min/1.73m2 in the latter This may explain the relationships found in NAC patients with criterion 2 with both prevalent and incident chronic kidney disease The matrix used in this study is a variant of that used by Iqbal et al. (13) in a European Delphi panel and by other authors in Spain (14), The Netherlands and Belgium (15) The biochemical criteria of our study have been very similar to those originally described by Iqbal et al. These authors considered the presence of hypocalcemia on at least 3-4 annual measurements as abnormal biochemical criterion In our study we have used only the Ca value from the last follow-up visit Our data indicate that there are few differences in the assessment of biochemical control using criteria 1 and 2 but a huge difference when criterion 3 is applied Criterion 3 of our study included the measurement of calciuria; therefore it could only be applied in 33% of the cohort due to the absence of this parameter in a large proportion of patients These results should make us recognize two aspects: first the importance of measuring calciuria in all patients and the convenience of the inclusion of calciuria in the biochemical criteria for assessing the adequacy of treatment for hypoparathyroidism the biochemical control criteria were less strict than in the present study calciuria was only available in a fraction of patients The retrospective multi-country chart review by Chen et al. (11) analyzed a cohort of 614 patients with hypoparathyroidism. Similar to our study, the majority (61.6%) were women and had postsurgical hypoparathyroidism (74.4%). However, the mean duration of disease was shorter (46 months) than that of our cohort. In the study by Chen et al. (11) the percentage of NAC patients was 28% this value of inadequacy is clearly lower than that found in our study with the most demanding criterion (criterion 3) which requires normality not only of calciuria but also of eGFR clinicians’ estimate of inappropriateness was only 11% in Chen’s study the assessment at the physician’s discretion was only applied to the patient’s well-being it can be seen that the objective assessment using biochemical data offers values ​​of poor control that are clearly higher than those obtained through subjective assessment or the doctor’s opinion The analytical assessment of patients with hypoparathyroidism is important not only for treatment adjustments, but also for its relationship with different comorbidities. The study by Underbjerg et al. (9) showed that patients with time-weighted low serum Ca had a higher risk of cardiovascular disease and patients with time-weighted high P had a higher risk of mortality and infection our finding on the relationship between dyslipidemia and NAC patients is not easy to explain from a mechanistic point of view Interpretation of our results from a global point of view would suggest that patients with a higher initial level of morbidity present a certain tendency toward poor control of hypoparathyroidism it seems reasonable to assume that patients with worse biochemical control of the disease will have a higher prevalence of eye disorders but also a greater number of outpatient visits and emergency room visits Other limitations include the retrospective nature of the study and the difference in patient monitoring and treatment protocols at different hospitals We also acknowledge that the assessment of patient well-being is limited by the absence of a defined clinical protocol for assessing patient symptoms or validated quality of life questionnaires Our study was limited to the setting of specialized medical care in Spain; therefore results cannot be extrapolated to other countries or settings the present study shows a high prevalence of NAC patients in the clinical practice of Spanish endocrinologists with expertise in hypoparathyroidism The main cause of NAC disease is the lack of normalization of the biochemical parameters of mineral metabolism Our data also suggest that inadequacy is associated with prevalent and incident comorbidities although further studies are necessary to confirm these results and define the risk factors and determinants of inadequacy in the control of chronic hypoparathyroidism The raw data supporting the conclusions of this article will be made available by the authors The studies were conducted in accordance with the local legislation and institutional requirements The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because our study is a retrospective study in which data from electronic medical records were reviewed All data were obtained following normal clinical practice No intervention or procedure was performed on the study subjects The author(s) declare that no financial support was received for the research The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fendo.2024.1464515/full#supplementary-material European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults Management of hypoparathyroidism: summary statement and guidelines A population-based study of the epidemiology of chronic hypoparathyroidism Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study Incident comorbidities in patients with chronic hypoparathyroidism after thyroidectomy: a multicenter nationwide study Presentation of hypoparathyroidism in Italy: a nationwide register-based study Management of hypoparathyroidism: present and future Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism Long-term complications in patients with hypoparathyroidism evaluated by biochemical findings: A case-control study HypoparaNet: A database of chronic hypoparathyroidism based on expert medical-surgical centers 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using a large claims database Epidemiology and diagnosis of hypoparathyroidism Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study The epidemiology of nonsurgical hypoparathyroidism in Denmark: A nationwide case finding study Epidemiology and health-related quality of life in hypoparathyroidism in Norway Evaluation and management of hypoparathyroidism summary statement and guidelines from the second international workshop Understanding the burden of illness associated with hypoparathyroidism reported among patients in the PARADOX study Health-related quality of life in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism Surgeons and patients disagree on the potential consequences from hypoparathyroidism Burden of illness in not adequately controlled chronic hypoparathyroidism: Findings from a 13-country patient and caregiver survey Metabolic syndrome in parathyroid diseases PubMed Abstract | Crossref Full Text | Google Scholar Cardiovascular risk in patients with primary hyperparathyroidism doi: 10.2174/1381612824999201105165642 Primary hyperparathyroidism and cardiovascular disease: an association study using clinical natural language processing systems and big data analytics Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D Postsurgical hypoparathyroidism–risk of fractures Long-term outcome of cataract surgery in patients with idiopathic hypoparathyroidism and its relationship with their calcemic status doi: 10.1146/annurev.nu.10.070190.001313 PubMed Abstract | Crossref Full Text | Google Scholar Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis Risk of permanent hypoparathyroidism after total thyroidectomy for benign disease: A nationwide population-based cohort study from Sweden Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: plea for improved follow-up Vertebral fracture assessment in postmenopausal women with postsurgical hypoparathyroidism Peinado M and Sastre J (2024) Prevalence of chronic postsurgical hypoparathyroidism not adequately controlled: an analysis of a nationwide cohort of 337 patients Received: 14 July 2024; Accepted: 05 September 2024;Published: 25 September 2024 Copyright © 2024 Díez, Anda, Pérez-Corral, Paja, Alcazar, Sánchez-Ragnarsson, Orois, Romero-Lluch, Sambo, Oleaga, Caballero, Alhambra, Urquijo, Delgado-Lucio, Fernández-García, Doulatram-Gamgaram, Dueñas-Disotuar, Martín, Peinado and Sastre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Juan J. Díez, anVhbmpvc2UuZGllekBzYWx1ZC5tYWRyaWQub3Jn †ORCID: Juan J. Díez, orcid.org/0000-0002-2017-0694 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish A collaboration between architecture studio Diez Office (Stefan Diez’s industrial design studio) urban greening specialists OMC°C and the American Hardwood Export Council (AHEC) "Vert"  is presenting an experimental set of modular structures at the London Design Festival 2024 Vert is being housed at Chelsea College of Art in London during the London Design Festival as well as declining biodiversity in cities around the world there is a need to rethink the model of urban development The project therefore proposes a sheltered space where people can rest in the shade of climbing plants combining aesthetic appeal with tangible environmental benefits representing a transformative approach to urban development The proposal developed by AHEC, Diez Office and OMC°C combines the experience of the project's collaborators in different fields to highlight the innovations that are being carried out in woodworking The tall sails covered with climbing plants capture carbon dioxide from the air and create sheltered spaces in which to rest forms a series of wooden triangles that support suspended biodegradable nets where the climbing plants are rooted in textile planters at the base of each net The sails are covered with about 20 different species of plants seeking to create a living ecosystem that enriches local biodiversity and serves as a habitat for essential insect populations while aesthetically improving the urban landscape and offering a sheltered meeting space in the heart of the city Project description by Diez Office “The structure performs as a ‘Greening Machine’ while also making urban spaces more harmonious and pleasant to live in from an aesthetic point of view We wanted Vert to break the monotony of our urban environment.” sustainableOver the last decade and a half AHEC has presented a host of experimental structural projects that showcase innovations in hardwood this time focusing on highlighting the potential of red oak glue-laminated timber (glulam) Having previously supported Stefan Diez in his teaching work AHEC and the Munich-based designer began exploring the possibility of collaboration at 3daysofdesign in Copenhagen in 2023 Diez Office had been working with OMCºC on their urban-greening solution that would reduce the carbon footprint of the city in the process This is the role typically performed by trees climbing plants can be more effective as they grow many times faster and can be ‘harvested’ annually to be turned into biochar or recycled as raw material for the generation of energy The system combines AHEC’s timber knowledge with Studio Diez’s design expertise and OMC°C’s in-depth understanding of planting and irrigation technology and all the other technical details integral to the installation of the structure in public spaces Vert’s triangular shape is fundamental to the structure’s performance allowing for a robust construction that uses minimal materials while being capable of resisting wind from all angles and absorbing the weight of the plants The triangle also lends itself to modularity allowing for the system to be extended or to change in direction to suit different settings without affecting the resistance of the structure Diez Office and OMC°C were able to identify red oak as the optimum material to use for the project in terms of both structural performance and ecological credentials Diez Office has been enthusiastic about the aesthetic possibilities and environmental benefits of red oak since learning about the species the studio has experimented with the timber For this project the whole construction team recognised its structural potential expanding its application to larger scales This has been made possible through the expertise of Bollinger + Grohmann structural engineers and Neue Holzbau a Swiss company known for its innovation in engineering and manufacturing complex timber structures Despite red oak being sustainable and constituting a sizable 18% of North American hardwood forests Increased use of red oak would reduce the stress on more widely used species and provide designers and customers with an enriched palette of timber materials to choose from Because red oak is denser and more stable than the standard construction timbers minimising the visual prominence and footprint of the structure while maintaining high structural performance The use of red oak also allows for more precise and long-lasting joints that enable the structure to be disassembled repaired and/or reassembled many more times than standard construction materials “Vert offered a tangible solution for urban greening integrating sustainable materials and modular timber construction to create a multifunctional space The idea perfectly aligned with our commitment to sustainability and our mission to highlight red oak’s structural and environmental characteristics inspiring the design and architectural community to consider it as a valuable material option.” The structure is predominantly made from red oak glulam – an engineered material created by finger jointing and laminating multiple grain-aligned layers of timber to enhance strength and stability structurally robust components suitable for modern construction Vert also features a decked floor beneath the sails made from thermally modified red oak The chemical-free heat treatment alters the wood's cellular structure enhancing its durability and stability and increasing its resistance to decay and insect attacks which makes it ideally suited to use outdoors in urban spaces such as this The case for sustainable timbersAs well as offering a potential urban-cooling solution and acting as visually enriching street furniture Vert makes a compelling case for the use of alternative wood materials to the limited library of species typically used in design and construction encouraging greater diversity and resilience in the world’s forests the standing timber volume of American forests has more than doubled over the last 50 years – a remarkable reforestation success story The forests provide critical habitats for wildlife and sources of economic growth for local communities Their trees – and the products made from their timber – play a significant role in combating climate change through carbon sequestration AHEC believes that timber and design industries have important contributions to make in the battle against climate change Vert’s use of red oak demonstrates a valuable material option that gives architects a sustainable solution with great structural properties while also tackling some of the most immediate impacts of climate change – specifically rising temperatures and diminishing biodiversity in global cities The cooling power of climbing plantsVert is projected to cool the surrounding airspace by as much as 8ºC cast four times more shade than a 20-year-old tree and produce as much biomass as an 80-year-old lime tree – all through the use of climbing plants grown over the course of a single summer “The project is intended to inspire urban planners architects and designers to address climate change and to work together to develop interdisciplinary solutions We want to show that you can implement large-scale greening even in the enclosed spaces of the inner city Our aim is to create a beautiful place for LDF: a cool buzzing place where you can be close to nature a garden for insects and people in the middle of the city – somewhere that does you good.” This project is in line with London’s ambitious climate goals included in the Mayor’s guidelines to increase tree cover by 10% by 2050 Vert presents a model for sustainable urban development in the era of climate crisis combining innovation with environmental stewardship to create liveable Diez Office Ed Reeve, Petr Krejci. Studio founded in 2002 by Munich-based industrial designer Stefan Diez The studio is dedicated to the design and development of everyday products focusing in particular on the potential of the circular economy and is characterized by innovation through technical expertise instinct and a great passion for experimentation its work has been at the forefront of transforming the ways in which contemporary products are developed and manufactured The studio works on typologies such as furniture creative experimentation and a rigorous commitment to sustainability Archive Art