Text description provided by the architects. On the narrow plot, surrounded by villas and large trees, the elongated residential building integrates the walls of the existing house. The split levels of the existing building are being reinterpreted and zone the ground floor: There are various floor offsets that create different spatial impressions. The building is set back slightly towards the street on the ground floor to mark the entrance. Internally the house is divided into two areas, which are connected by a two-story gallery with a large glazing. In the front part of the house, the open structure offers space for the foyer, guest area, and vernissage. An open staircase allows direct access to the upper floor and the basement. T © David SchreyerDue to prevention of overheating the large glass surfaces of the longitudinal facade are aligned to the north Floor-to-ceiling windows and interior doors made of oak contrast with the raw concrete surfaces and the polished terrazzo floor The homogeneous dark facade visually wraps the different window formats You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email On a narrow plot in Dreieich, Germany, surrounded by villas and large trees, Tiefes Haus reinterprets the split-level design of the original structure, integrating existing walls into a modern elongated residential building The ground floor is zoned through various floor offsets Designed by Henning Grahn Architektur (HGA) and Marc Flick the building is slightly set back at the ground level to define the entrance all images by David Schreyer Henning Grahn Architektur (HGA) and architect Marc Flick divide the interior into two primary areas connected by a two-story gallery featuring extensive glazing The front section of the house includes an open layout accommodating the foyer with an open staircase providing direct access to the upper floor and basement The upper floor is organized into a children’s area and a sleeping area connected by a concrete walkway through the gallery A continuous roof ties the two sections together the large glass surfaces of the longitudinal facade are oriented northward The design contrasts floor-to-ceiling windows and oak interior doors with raw concrete surfaces and polished terrazzo flooring The homogeneous dark facade unifies the different window formats Tiefes Haus reinterprets the split-level design on a narrow plot in Dreieich large glass surfaces on the longitudinal facade are oriented northward to prevent overheating the homogeneous dark facade visually unifies the different window formats of the house floor-to-ceiling windows contrast with raw concrete surfaces in the interior design a two-story gallery with extensive glazing connects the primary areas of the interior the kitchen and living room in the rear offer expansive views of the garden a concrete walkway through the gallery connects the two upper-level areas oak interior doors and polished terrazzo flooring add warmth to the raw material palette name: Tiefes Haus architects: HGA Henning Grahn Architektur | @hga.archi, Marc Flick – Architekt BDA | @marcflick.architektur photography: David Schreyer | @schreyerdavid_bild designboom has received this project from our DIY submissions feature, where we welcome our readers to submit their own work for publication. see more project submissions from our readers here. edited by: christina vergopoulou | designboom AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style Manufacturing Today India Home > Electronics & Semiconductors > Texas Instruments opens an advanced 9,000 Sq The new distribution facility allows for quicker product delivery throughout Europe Texas Instruments declared that their new product distribution facility in Dreieich This new distribution centre has innovative automation features and 9,000 square metres of area Up to 7,500 orders for a variety of TI analog and embedded processor semiconductors may be swiftly shipped around Europe every day from the new facility The new product distribution centre provides TI’s clients in Europe with faster and dependable service to fulfil semiconductor demand both today and in the future In addition to our flexible purchase choices the new Dreieich centre is the most recent addition to TI’s worldwide product distribution network which enhances the customer experience from product selection to shipment which is close to the Frankfurt Airport and many of TI’s industrial and automotive clients allows for quicker product delivery throughout Europe Orders are prepared for shipment in 15 minutes or less thanks to the completely automated select While other European nations provide next-day delivery clients in central Germany may anticipate same-day goods delivery Cultural events and jubilees not to miss out on the new old town of Frankfurt and one of the top culinary destinations in Bavaria - this and much more in this press release! The culinary delights of Miltenberg in Bavaria Celebrating the 800-year jubilee of Goldbach in Spessart something very special is going on in the region of Spessart: The city of Goldbach (meaning “the golden stream”) has planned a grand celebration for its 800-year jubilee on June 8–17 will make this an event that should not to be missed The musical activities will be complemented with culinary temptations and smaller Goldbach is situated close to tourist magnets like Aschaffenburg one of the most significant Renaissance castles in Germany There are several other recommendable attractions in the Spessart region including the previously mentioned city of Miltenberg and the beautiful moated castle of Mespelbrunn This area is also perfect for outdoor activities Don’t hesitate to contact us for more information about the Spessart region and its highlights New museum in the art city of Aschaffenburg Get a new perspective on things at RESTAURANT 360° in Limburg a report by The Economist Intelligence Unit This means that Frankfurt is currently considered one of the safest of 60 cities in the world to visit This is just one of many reasons to visit Frankfurt and the surrounding region where several historic and culinary delights await you the Frankfurt Rhine-Main region is packed with events Did you miss the last press release with an overview of the events in 2018 Or would you like to read more about the spectacular inauguration in Frankfurt in 2018 in our press area at http://news.cision.com/frankfurt-rhine-main-region the house is embedded in a quite typical suburban settlement that had been developed during the 1960s this settlement depicts both the aesthetics of an increasingly wealthy yet rather conservative and homogeneous suburban society and a heavily plural and individualist approach towards the aesthetics of private houses that manifest themselves in a rather eclectic collage of styles since the 1990s one fine day’s house is based on strictly ordered geometrical relations that allow for a certain degree of elasticity to respond to different demands of the client the building stretches as an elongated volume from northwest to southeast and exploits solar gains protecting the garden from the noisy street at its north side the slightly deformed volume adopts the directions and comparably low heights of the neighboring eave lines it is then raised at its center in order to softly translate the obliqueness of the neighboring roofs and blend them with the advantages of an explicitly modern flat roof the house’s south façade has to serve several important yet contradictory functions at once — it has to be inviting and representative as it organizes the casual cohabitation of an everyday family life the exploration of different outside spaces the terrace that enlarges the adjacent living room the roof terrace that completes the master bedroom and the roof garden in front of the children’s rooms used for strengthing the connection of the house and garden as well as defining the building’s boundaries There are no statistics available for this player Thanks for visiting ! 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Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1118358 The inhibition of renal SGLT2 glucose reabsorption has proven its therapeutic efficacy in chronic kidney disease SGLT2 inhibitors (SGLTi) have been intensively studied in rodent models to identify the mechanisms of SGLT2i-mediated nephroprotection the overwhelming effects from clinical trials could only partially be reproduced in rodent models of renal injury a commonly disregarded observation from these studies is the increase in kidney weight after SGLT2i administration Increased kidney mass often relies on tubular growth in response to reabsorption overload during glomerular hyperfiltration Since SGLT2i suppress hyperfiltration but concomitantly increase renal weight it seems likely that SGLT2i have a growth promoting effect on the kidney itself This study aimed to investigate the effect of SGLT2i on kidney growth in wildtype animals to identify enlarged nephron segments and classify the size increase as hypertrophic/hyperplastic growth or cell swelling SGLT2i empagliflozin increased kidney weight in wildtype mice by 13% compared to controls while bodyweight and other organs were not affected The enlarged nephron segments were identified as SGLT2-negative distal segments of proximal tubules and as collecting ducts by histological quantification of tubular cell area while tubular nuclei number (hyperplasia) was unchanged by empagliflozin SGLT2-inhibition in early proximal tubules induces a shift of NaCl resorption along the nephron causing compensatory NaCl and H2O reabsorption and presumably cell growth in downstream segments in collecting ducts of empagliflozin-treated mice mRNA expression of the Na+-channel ENaC and the H2O-channels Aqp-2/Aqp-3 were increased the hypoxia marker Hif1α was found increased in intercalated cells of the collecting duct together with evidence for increased proton secretion as indicated by upregulation of carbonic anhydrases and acidified urine pH in empagliflozin-treated animals these data show that SGLT2i induce cell enlargement by hypertrophic growth and possibly cell swelling in healthy kidneys probably as a result of compensatory glucose NaCl and H2O hyperreabsorption of SGLT2-negative segments Particularly affected are the SGLT2-negative proximal tubules (S3) and the collecting duct a clear picture of the underlying mechanisms of renal protection by SGLT2 inhibitors in patients without type II diabetes is still missing it should be mentioned that the majority of these findings refer to data from diabetic patients and rodent models with diabetic background Whether these factors are also relevant in non-diabetic renal protection by SGLT2 inhibitors remains to be elucidated A possible explanation provides the suggested shift of NaCl and glucose reabsorption to further distal nephron segments in response SGLT2 inhibition in early proximal tubule cells Stimulated glucose reabsorption in the proximal S3 segment and augmented NaCl uptake in the thick ascending limb distal tubule and collecting duct possibly triggers compensatory cell growth in these segments interstitial edema formation and/or compensatory H2O reabsorption in response to osmotic diuresis could explain increased kidney weight under SGLT2 inhibition healthy wildtype animals were treated with the SGLT2 inhibitor empagliflozin for 8 weeks and organ weight and hypertrophic cell growth were analyzed using microscopic (quantification of tubular cell size) and molecular approaches (protein/DNA ratio in isolated tubules) Germany) to proof the efficiency of EMPA treatment All experimental procedures were conducted in accordance with the German Animal Welfare Act and approved by the local authorities (government of Lower Franconia file number RUF 55.2.2–2532.2-896–13) After 8 weeks EMPA-treated and control animals were killed by cervical dislocation one kidney was perfused via the abdominal aorta with 0.9% NaCl solution followed by a 4% paraformaldehyde perfusion fixation (3 min; 100 mmHg constant pressure) and paraffin-embedding snap-frozen in liquid nitrogen and stored at −80 °C for RNA extraction Paraffin-embedded kidneys were sectioned (5 µm) deparaffinized and stained with primary antibodies for well-established tubulus-specific marker proteins using a standard paraffin staining protocol United States) was used as a marker for the proximal tubule S1-S3 segment United Kingdom) for the proximal tubule S1/S2 segment Switzerland) for the distal convoluted tubule United States) for the principle cells of the collecting duct and V-ATPase B1/2 (sc-55544 United States) for intercalated cells of the collecting duct After staining with a fluorescence-labeled secondary antibody whole kidney overview images were acquired using the Zeiss Axio Observer 7 (Carl Zeiss AG As a measurement of cell area per tubule segment the total area of each 50 segment-specific tubules was quantified using the Zeiss ZEN software (Carl Zeiss AG Germany) and divided by the number of DAPI-stained cell nuclei Relative expression of target genes was calculated using 2−ΔCt analysis method The housekeeper Ct used for normalization was obtained from a pool of Ct values of different housekeeping genes Data are depicted in relation to the expression level in the H2O control group (100%) For detection of Hif1α in the kidney 5 µm sections were deparaffinized and boiled in Target Retrieval Solution (S1699 Germany) for 15 min using a steam pressure pot After several washing steps sections were blocked with Avidin (SP-2001 followed by 3% H2O2 treatment for 10 min and a serum-free protein blocking step (X0,909 Sections were incubated with the primary antibody against Hif1α (10006421 United States) over night at 4 °C United States) was added for signal amplification (15 min) sections were incubated with Streptavidin-HRP conjugate for 30 min (ab64269 United States) was added and the formation of the brown precipitate was closely monitored under the microscope until sufficient intensity was obtained and the reaction was stopped by immediate rinsing For Hif1 α costainings with tubular marker proteins the additional primary antibodies for megalin Aqp-2 and V-ATPase B1/2 (see section immunofluorescence staining) were visualized by incubation with appropriate Cy5-coupled secondary antibodies for 60 min For unbiased quantification of Hif1α signal (brown staining) we used the Zeiss ZEN Intellesis Image segmentation software (Carl Zeiss AG the software uses a machine-learning algorithm for automated identification of stained areas based on an individual training for each tissue class We defined three different classes recognizing background areas kidney tissue areas or Hif1α-positive areas Spot urine was collected before the experiment and at week 1 five and seven post EMPA treatment for pH measurement using a standard pH meter (model 766 A second cohort of male C57BL/6 wildtype mice was treated with EMPA (Carbosynth Limited United Kingdom) for 2 weeks and kidneys were microdissected for the selection of isolated tubules of the proximal S3 segment and the collecting duct the kidneys were perfused via the abdominal aorta with 10 mL incubation solution (140 mmol/L NaCl 1 mmol/L α-ketoglutaric acid pH 7.4 at 37°C) containing 0.1 mg/mL collagenase II (Sigma Aldrich Sorting solution was prepared by adding 1 mg/mL PVA 4–88 (Sigma Aldrich cut into slices and transferred into 1 mL prewarmed collagenase-containing (1 mg/mL) incubation solution in a 37°C thermoshaker (Eppendorf Germany) for 10 min at 850 rpm After adding 1 mL prewarmed incubation solution 1 mL of the digested tubule solution was transferred into a new tube and kept on ice for sedimentation This step was repeated 10x every 5 min resuspended in 2 mL of sorting solution and 100 proximal S3 segments and 100 collecting ducts were separated by visual sorting under a stereomicroscope at 4°C 4°C) and tubule pellets were frozen at −80°C 200 µL autoclaved MilliQ water were added and tubule lysis was initiated by a 60 min incubation in a thermoshaker (37°C) before they were snap-frozen in liquid nitrogen Samples were thawed again and subjected to ultrasonic treatment (UW 2070; Bandelin electronic This freeze/thaw/ultrasound treatment was repeated three times and the supernatant was used for protein and DNA measurement Three immortalized renal cell lines were used in this study as in-vitro models for proximal tubule cells (LLC-PK1 cells; provided by Prof Porcine LLC-PK1 cells were cultured in DMEM/F12 medium (Thermo Fisher Scientific GmbH Germany) supplemented with 10% FBS (PAN-Biotech GmbH Germany) and 1% penicillin/streptomycin (Capricorn Scientific GmbH Canine MDCK-C7 cells were cultured in DMEM low glucose medium (Capricorn Scientific GmbH Murine M-1 cells were cultured in DMEM/F-12/Glutamax medium (Thermo Fisher Scientific GmbH 1% ITS and 100 nM dexamethasone (Thermo Fisher Scientific GmbH The cells were maintained at 37°C under a humid atmosphere of 95% air and 5% CO2 Two days before the experiment 1 × 105 (MDCK-C7 LLC-PK1) or 0,75 × 105 (M-1) cells were seeded in 24 well plates and standard medium was replaced by serum-starved medium after 24 h cells were stimulated with EMPA 1 µM or TGF-ß 500 p.m United States) in serum-starved medium for 24 h For cell lysis 400 µL autoclaved MilliQ were added to each well and the plate was incubated at 37°C for 1 h before it was frozen at −80°C cell lysates were transferred to a sterile tube and stored at −20°C until measurement of the protein/DNA ratio was performed Fluorometric quantification of double-stranded DNA by intercalation of Hoechst 33258 was conducted using the Fluo Reporter® Blue Fluorometric dsDNA Quantitation Kit (Thermo Fisher Scientific GmbH Germany) following the manufacturer’s guidelines Germany) with a defined concentration was used to generate a standard curve Fluorescence intensity of DNA-bound Hoechst 33258 was measured on a Cary Eclipse Fluorescence Spectrophotometer (Agilent Germany) using a 360nm/460 nm excitation/emission filter set Standard colorimetric kits were used for protein quantification of lysates from isolated tubules (740967.50 To compare protein/DNA ratios between different cell lines data are depicted in relation to the DMSO control group (100%) an unpaired Student’s t-test was used to calculate the level of significance for multi-group comparisons at different time points a two-way ANOVA followed by a Bonferroni post hoc test was used All statistical analyses were performed using the GraphPad Prism software Differences between groups were considered significant at a p < .05 In a previously published study by our group, wildtype mice with unilateral nephrectomy (UNx)/DOCA/salt-induced renal injury showed an increase in renal weight under SGLT2 inhibition by empagliflozin (EMPA) (Tauber et al., 2021) Renal weight gain was also observed in healthy control mice and was therefore not related to the compensatory hyperfiltration elicited by UNx we used healthy wildtype animals to investigate how EMPA affects kidney weight in normofiltrating kidneys Histological quantification of tubular cell area was performed to identify enlarged nephron segments and protein/DNA ratio was measured in isolated tubules as a marker for cellular hypertrophy SGLT2 inhibition did not affect organ weight excluding a general effect of EMPA on organ weight Increased kidney weight in EMPA-treated mice Wildtype animals were treated with EMPA (30 mg/kg/d; n = 16) for 8 weeks and untreated animals were used as control (n = 12) Kidney weight (A) was increased in EMPA-treated animals compared with H2O control animals while there were no differences in bodyweight (B) Bar charts show mean values (±SEM) and asterisks indicate p < 0.05 which is why the hyperplasia hypothesis was not further pursued Hyperplastic growth is defined by an increase in cell number due to stimulated proliferation and DNA amplification resulting in a higher number of cell nuclei per tubule Increased tubular size in EMPA-treated mice (A) Kidney overview images (DAPI staining) demonstrate increased kidney size (B) in 8-week EMPA-treated animals (30 mg/kg/d) (C) Representative immunofluorescence staining of different nephron segments of EMPA treated animals (n = 8; H2O animals n = 4) Proximal tubule EMPA-target cells (S1/S2) show positive megalin (red) and Sglt2 (green) co-staining Sglt2 negative tubules represent the proximal tubule S3 segment Tamm-Horsfall protein (THP; purple) was used as marker for the thick ascending limb calbindin (orange) as marker for the distal tubule and aquaporin-2 (Aqp-2; yellow) as marker for the collecting duct DAPI (blue) was used for cell nuclei staining Red circles show exemplarily which tubules were included in the analysis shown in (D) (D) Quantification of tubular cell area per nephron segment Only tubules with vertical orientation were considered for cell area quantification (red circles) was normalized to the number of DAPI positive cell nuclei per tubule Megalin positive tubules were further subclassified in Sglt2 positive and negative proximal tubules Protein/DNA ratio in isolated tubules and renal cell lines after EMPA treatment (A) Microdissected proximal S3 segments and collecting ducts of EMPA-treated mice (30 mg/kg/d for 8 weeks; n = 11) showed a slight non-significant increase of the protein/DNA ratio compared with H2O control mice (n = 10) Impact of EMPA on protein/DNA ratio in three renal cell lines (n = 7–11 with three to six replicates each) After 24 h EMPA treatment (1 µM) protein/DNA ratio was significantly reduced in LLC-PK1 cells In MDCK cells the EMPA-induced reduction of the protein/DNA ratio was not statistically different to control cells increased the protein/DNA ratio in MDCK cells To compare protein/DNA ratios between different renal cell lines data are depicted in relation to the expression level in the DMSO control group (100%) mRNA quantification of sodium channel ENaC subunits (A) and aquaporins in kidneys and vasopressin in brains (B) of untreated wildtype mice (n = 8) and mice treated with EMPA (30 mg/kg/d; n = 8) for 8 weeks Induction of Hif1α in intercalated cells by SGLT2 inhibition (A) Overview images of Hif1α stained kidneys (brown) of untreated wildtype mice (n = 4) and 8 weeks EMPA-treated mice (30 mg/kg/d; n = 8) (B) Quantification of total kidney Hif1α positive areas total tubule tissue area and the resulting ratio using the ZEN Intellesis image segmentation software (C) Immunofluores-cence costaining of Hif1α (black) with marker proteins for the proximal tubule (megalin; red) thick ascending limb (Tamm-Horsfall protein distal convoluted tubule (calbindin; orange) principle (Aqp-2; yellow) and intercalated (V-ATPase; green) cells of the collecting duct Hif1α was found in some calmodulin positive tubules but mostly in V-ATPase positive intercalated cells of cortical and medullary collecting ducts Urine pH and kidney mRNA expression of carbonic anhydrases in EMPA-treated animals Wildtype animals were treated with EMPA (30 mg/kg/d; n = 8 per group) for 8 weeks (A) Spot urine pH was more acidified in EMPA-treated animals compared to control mice at all timepoints (B) mRNA quantification of selected carbonic anhydrases in kidneys of EMPA-treated mice It has to be mentioned that only this study used healthy wildtype animals while most expression analysis data derive from rodent disease models for diabetes or salt-induced hypertension treatments known to affect renal Na+ handling itself fluid-induced cell swelling might contribute to the enlarged cells size of collecting duct cells in EMPA-treated mice reduced NaCl uptake in the early proximal tubule with subsequent increased NaCl reabsorption in distal segments like the collecting tube possibly affects the acid-base handling of the intercalated cells in response to increased ENaC activity in principle cells Na+ reabsorption by ENaC increases the driving force for K+ secretion via ROMK into the urine which can be reabsorbed by the H+/K+-ATPases in exchange for a proton causing urinary acidification ENaC uptake assays and metabolic profiling was not performed in this study and further experiments are needed to address these issues in wildtype mice under SGLT2 inhibition this study addressed the mechanism underlying renal weight gain in the healthy kidney during SGLT2 inhibitor treatment Hypertrophic growth was observed in the proximal S3 segment and the collecting duct fluid induced cell-swelling seems likely as an additional cause for the microscopically quantified increase in tubular cell volume an induction of Hif1α by empagliflozin was described in intercalated cells of healthy kidneys possibly as a consequence of increased ATP-demanding proton secretion The raw data supporting the conclusion of this article will be made available by the authors The animal study was reviewed and approved by the Government of Lower Franconia Germany (file number: RUF 55.2.2-2532.2-896-13) FSi: technical implementation of in vivo experiments and histological data analysis (doctoral thesis) AF: technical support with renal tubule microdissection AB: technical implementation of renal tubule microdissection and quantification of protein/DNA ratio MS: technical implementation of cell culture experiments PT: project administration and supervision All authors contributed to manuscript revision This study was funded by the Deutsche Forschungsgemeinschaft (DFG project number 387509280 (SFB 1350) and 509149993 (TRR374) Katharina Ortmaier and Sabrina Habel (Institute of Physiology Germany) for their excellent technical assistance and Prof Switzerland) for his support with ENaC antibodies The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2023.1118358/full#supplementary-material Empagliflozin in heart failure with a preserved ejection fraction PubMed Abstract | CrossRef Full Text | Google Scholar Responses of renal hemodynamics and tubular functions to acute sodium–glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats PubMed Abstract | CrossRef Full Text | Google Scholar Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy PubMed Abstract | CrossRef Full Text | Google Scholar Borges-Júnior Empagliflozin inhibits proximal tubule NHE3 activity and restores euvolemia in nondiabetic rats with induced heart failure PubMed 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with type 2 diabetes: A slope analysis from the EMPA-REG outcome trial PubMed Abstract | CrossRef Full Text | Google Scholar Empagliflozin and progression of kidney disease in type 2 diabetes PubMed Abstract | CrossRef Full Text | Google Scholar Glomerular filtration rate and kidney size in type 2 (non-insulin-dependent) diabetes mellitus PubMed Abstract | Google Scholar Dapagliflozin and cardiovascular outcomes in type 2 diabetes PubMed Abstract | CrossRef Full Text | Google Scholar Molecular mechanisms of diabetic renal hypertrophy PubMed Abstract | CrossRef Full Text | Google Scholar Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Schweda F and Tauber P (2023) Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct Received: 07 December 2022; Accepted: 14 March 2023;Published: 23 March 2023 Copyright © 2023 Sinha, Federlein, Biesold, Schwarzfischer, Krieger, Schweda and Tauber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Philipp Tauber, UGhpbGlwcC5UYXViZXJAdXIuZGU=; Frank Schweda, RnJhbmsuU2Nod2VkYUB1a3IuZGU= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish has moved stables and received a new rider Nina Kudernak said goodbye to the bay gelding and Bianca Nowag welcomed him in her barn in Warendorf Queolito is an 11-year old Hanoverian gelding by Quaterhall out of Feolito (by Furst Romancier x Warkant) The bay gelding began his competition career as a 4-year old in 2016 under Claudia Feldmann She took him from the riding horse tests in to the dressage horse L-level tests in 2017 Feldmann's last show was in September 2017 after which owner Melissa Grasser found a new rider for him The 28-year old professional dressage rider Nina Kudernak took over the ride She made her show debut on Queolito in April 2018 at M-level In 2019 they moved up to small tour level and by May 2021 they reached Intermediaire II level The pair's best season was in 2022 when they showed in the Louisdor cup qualifiers at high profile national competitions in Darmstadt, Wiesbaden, Balve, and Kronberg, and cracking the 70% barrier. They won the last qualifier in Donzdorf At the 2022 Louisdor Cup Finals for developing Grand Prix horses in Frankfurt the pair finished 10th with 65.160% after the horse had difficulties coping with the electric atmosphere in the warm-up round (63.893%) For 12 years Kudernak was based at Conrad Schumacher's Hofgut Neuhof in Dreieich Since 2019 she got coaching from German U25 team trainer Sebastian Heinze On 1 July 2022 Kudernak moved to the riding club in Neu Isenburg Since January 2022 she has been working with Monica Theodorescu Grasser moved the horse from Kudernak to Nowag Related LinksFinalists for the 2022 Louisdor Cup in Frankfurt Borsalino and Finest Pearl Win 2017 Wolfskehlen Bundeschampionate Qualifier Stalls for Rent at Durondeau Dressage in Peer, Belgium Exceptionally Well Located Equestrian Facility in Wellington, Florida Well-built Equestrian Estate With Multiple Business Opportunities in Sweden Stable Units for Rent at Lotje Schoots' Equestrian Center in Houten (NED) For Rent: Several Apartments and Stable Wing at High-End Equestrian Facility Stable Wing Available at Reiterhof Wensing on Dutch/German border Real Estate: Well-Appointed Country House with Extensive Equestrian Facility in the U.K. Rémi Blot View full results for German International Amateur Home | Tournaments | Courses | Equipment | Players | Rankings | About Us | Contact This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Dreieich, 18th October 2018. Hahn Air has already integrated 20 new carriers into its global network of more than 350 air rail and shuttle partners by the end of the third quarter of this year nine are new interline agreements and eleven are new partners of H1-Air a product of the global consolidation service Hahn Air Systems. The services of the following nine airlines are now available on the HR-169 ticket under their own designator thanks to an interline agreement with Hahn Air The flights of the eleven new partners of the consolidation service Hahn Air Systems are now available under the reservation code H1 in all GDSs Travel agents in 190 markets can book their services and issue them on the HR-169 ticket 2018 saw agreements with the following airlines and tour operators: “We are especially pleased that two of our new interline partners are now making use of a dual partnership with the Hahn Air Group which means they are combining an interline agreement with our H1-Air product” Vice President of the Airline Business Group at Hahn Air “Lanmei Airlines and Africa World Airlines are therefore now available on the Hahn Air ticket under their own IATA codes while at the same time they can be issued in all major GDSs under the Hahn Air Systems code H1 This is a growing trend among our customer airlines as it gives them a truly global approach to indirect distribution via travel agencies.” With its ticketing and distribution solutions the German airline Hahn Air facilitates global business between travel agencies and airlines Its global connectivity with all major Global Distribution Systems (GDS) and almost all Billing and Settlement Plans (BSPs) enables 100,000 travel agents worldwide to issue transportation services of Hahn Air partners on the HR-169 ticket More information about air, rail and shuttle partners available on the HR-169 ticket can be found on www.hahnair.com About Hahn AirHahn Air is a German scheduled and executive charter airline founded in 1994 Since 1999 it has specialised in distribution services for other airlines and has established itself as the market leader in indirect ticket distribution Hahn Air covers 190 markets and cooperates with more than 350 air rail and shuttle partners as well as over 100,000 travel agencies Although Hahn Air offers these distribution and ticketing services exclusively to transportation companies and travel agents travellers benefit as well from being able to choose from more carriers Every year millions of passengers travel between 4,000 locations using Hahn Air’s HR-169 tickets It is the first and only airline worldwide that offers free and comprehensive reimbursement in case of insolvency of the operating carrier Hahn Air is a member of the International Air Transport Association (IATA) and a globally connected stakeholder playing a leading role in the airline industry Hahn Air is 100% owned by the Hahn Air Group an international corporation based in Dreieich near Frankfurt The fleet of Hahn Air Lines operates out of the airports Dusseldorf and Frankfurt Egelsbach achieves an annual global turnover of approximately 1 billion USD for its clients ContactAndrea MüllerCorporate Communications ManagerHahn Air Lines GmbHTel: +49-6103-7331-421E-Mail: a.mueller@hahnair.comAshvin Rajendram SivajothiCorporate Communications ManagerHahn Air Lines GmbHTel.: +49-6103-7331-430 E-Mail: a.sivajothi@hahnair.com www.hahnair.com Facebook: https://www.facebook.com/HahnAir Twitter: https://twitter.com/HahnAirLinesYouTube: https://www.youtube.com/user/TravelAgentMartin The company is extending its suite of products for partner airlines and travel agencies with a solution powered by IATA’s New Distribution Capability (NDC) standard the German airline and ticketing expert welcomed the first passengers holding NDC-enabled Hahn Air tickets on one of its scheduled flights from Luxembourg to Dusseldorf on 16th August 2019 “As Hahn Air today supports travel agencies in 190 markets and airlines of any size and business model we carefully developed a scalable solution that meets the needs of all our current and future partners in a changing airline industry” “We are leveraging on the expertise we have acquired during our 20 years of being the leader in airline distribution solutions as well as our involvement in the IATA activities driving and developing the NDC standard from the very beginning We have been actively participating in several IATA committees and are currently holding the chair position of the NDC Orders Group as well as a seat on the Shop-Order Board and the Architecture and Technology Strategy Board.” Hahn Air’s NDC platform will bring the following benefits to partner airlines: a proprietary Application Programming Interface (API) or traditional reservation and ticketing interfaces – whether it is an existing Hahn Air partner airline or not – will be able to take advantage of Hahn Air’s new NDC solution. This includes access to Hahn Air’s network of connected agencies and aggregators with the option to make additional connections to the airlines’ preferred agency partners The new NDC platform is powered by 2e Systems a software development company specializing in web mobile and communications solutions for the airline industry For more details about Hahn Air and its solutions for partner airlines and travel agents, visit www.hahnair.com Markus Engelbrecht welcomes the first passengers travelling with NDC-enabled tickets on the scheduled flight HR331 from Luxembourg to Düsseldorf on August 16th 2019 About Hahn AirHahn Air is a German scheduled and executive charter airline Since 1999 it offers indirect distribution services to other airlines and thus provides ticketing solutions to 100,000 travel agencies in 190 markets the company has established itself as the market leader Hahn Air’s partner network encompasses more than 350 partner airlines Hahn Air offers its distribution services exclusively to transportation companies and ticketing solutions to travel agents only FlySafair enters global distribution with Hahn Air entered into an agreement with Hahn Air to distribute its flights via travel agents worldwide The airline’s inventory will be available for ticketing on the Hahn Air HR-169 document in all major Global Distribution Systems (GDSs) worldwide Hahn Air is a German scheduled airline and the leading provider of distribution services for other airlines FlySafair joins Hahn Air’s network of more than 300 air rail and shuttle partners and expands its commercial reach to 100,000 travel agencies in 190 markets worldwide The airline is the 7th partner to benefit from two products of the Hahn Air Group to optimise its distribution strategy The so-called dual partnership combines both the H1-Air product and an HR-169 interline agreement FlySafair will be available in the GDSs Amadeus and Galileo under their own designator FA as of [month] 2017 and can be issued by travel agents on the HR-169 ticket FlySafair is already available in all major GDSs worldwide under the reservation code H1 and can also be ticketed on HR-169 ticket stock FlySafair benefits from a full suite of services including scheduling “By combining the two Hahn Air products FlySafair is fully optimising their distribution strategy” Vice President of the Airline Business Group at Hahn Air.” Through our H1-Air product FlySafair successfully outsources its complete indirect distribution while eliminating risk and saving costs H1-Air also allows FlySafair to enter the GDS world immediately and cover all major GDSs with minimal effort By complementing the H1-product with a HR-169 interline agreement our partner can choose to sell flights under its own two letter code in key markets via selected GDSs.” FlySafair is a low-cost airline based at Oliver Reginald Tambo International Airport (JNB) in Johannesburg The airline is part of 51-year old specialised aviation services company and serves 7 domestic destinations with a fleet of nine Boeing 737 aircraft FlySafair’s GDS inventory includes a 23kg checked-in baggage allowance free priority boarding and two flight changes without penalty fees although fare differences will be applicable Ticketing time limits vary by fare class from a few hours to 48 hours “We are very excited to welcome FlySafair into our customer portfolio broadening our footprint in South Africa and enhancing our H1-Air network with our 15th African partner carrier” “It was our intention to find a smart and cost-efficient solution to make all FlySafair routes available in the GDSs” Head of Sales and Distribution at FlySafair “We completed the first phase of our GDS roll-out with the implementation of H1-Air in November Phase two consists of an interline agreement with Hahn Air and direct integrations with Amadeus and Galileo This will give us the opportunity to offer a slightly more competitive fare in our local markets.” For more information about FlySafair and Hahn Air’s services for partner airlines, visit www.hahnair.com 39 Stunden steht jeder deutsche Pendler pro Jahr durchschnittlich im Stau die zu Hauptverkehrszeiten durch Dreieich Buchschlag müssen Die Gründe sind hier nicht Baustellen oder Unfälle In Gießen beginnt ein Prozess gegen einen Mann und seine Lebensgefährtin Sie sollen eine Frau mit Down-Syndrom gequält und ermordet haben Die Stadt Kassel rechnet dadurch nach eigenen Angaben mit jährlichen Mehreinnahmen von etwa 3 Millionen Euro die Stadt Offenbach von etwa 1,3 Millionen Euro Der Hotel- und Gastronomieverband Dehoga Hessen rät Kommunen eindringlich davon ab Die Bad Hersfelder Festspiele finden dieses Jahr zum letzten Mal unter der Intendanz von Joern Hinkel statt Am Dienstag ist Probenbeginn von Hinkels Fassung des Shakespeare-Stückes „Ein Sommernachtstraum“ unter dem Titel „Sommernachtsträume“ Mit dabei sind Schauspiel-Größen wie Erol Sander und Anouschka Renzi hier entlang… WordPress Video Theme by WPZOOM Essenzielle Cookies ermöglichen grundlegende Funktionen und sind für die einwandfreie Funktion der Website erforderlich Inhalte von Videoplattformen und Social-Media-Plattformen werden standardmäßig blockiert Wenn Cookies von externen Medien akzeptiert werden bedarf der Zugriff auf diese Inhalte keiner manuellen Einwilligung mehr Galway United are delighted to announce the signing of Joshua Smith The 27-year-old American defender joins the club from Finn Harps Smith helped the Ballybofey outfit to secure their Premier Division status in 2019 the 6’3 centre-back scored the only goal in a 1-0 win against Waterford FC at Finn Park in October The Louisiana native joined Finn Harps midway through the 2019 season from German side SC Hessen Dreieich but he began his career in the academy sides of Kaiserslautern and Karlsruher SC in Germany Smith’s first taste of senior football came at SC Idar-Oberstein The commanding defender returned to America to play college football for the University of San Francisco and then he was drafted by MLS side New England Revolution Galway United manager Alan Murphy was thrilled to add a defender of Smith’s calibre to his squad for 2020. Murphy told www.galwayunitedfc.ie that Smith joins the club with a lot of experience behind him from playing in different countries and he was delighted to secure one of his top transfer targets “Josh Smith may only have moved to Ireland in the last transfer window but we knew from the first night we saw him play that we wanted him at Galway United for 2020 and beyond “We’ve been to watch him individually or collectively a number of times and never failed to be impressed Josh just ticks so many boxes that he immediately became a priority signing for us Josh is dominant in both boxes and he’s got an excellent positional sense he’s looked an obvious leader and organiser from the outset he is about to enter his prime years as a centre-back and I’ve no doubt he will be a massive part of what we are trying to create here “Josh has enjoyed an excellent footballing education at some of the best clubs in America and Germany and that is very obvious from once you speak to him as he is such a quick learner and an extremely coachable guy I cannot wait to work with him in the new year and I think Josh is even more eager to get started Smith is excited about playing in the SSE Airtricity League again next season and he’s focused on helping the Tribesmen to achieve their goals in the coming year “I’m delighted to be here,” Smith explained “Yesterday I stepped off the bus and I fell in love with the town already I’ve played in the youth system with Kaiserslautern and Karlsruher in Germany before playing in the US in college football and the MLS Most recently I was with Finn Harps in the Premier Division last season “I’m very grateful to Alan for bringing me into the club and trusting me It was my goal to come into Finn Harps and help them stay in the Premier Division Now my goal is to help this club achieve its goals for next season “Alan has a great aura and energy about him He’s very passionate about the club and about what he did with the youth last season He spoke about what he’s looking to do next season so for me it was a no-brainer to jump in and give everything I have and hopefully we will achieve what we want together I’ll look to bring the experiences that I have from playing in the MLS Dieser Service kann Daten zu Ihren Aktivitäten sammeln Bitte lesen Sie die Details durch und stimmen Sie der Nutzung des Service zu Der Besitzer der Website muss diese mit seinem CMP einrichten um diesen Inhalt zur Liste der verwendeten Technologien hinzuzufügen die von der Deutschen Bahn bestellt wurden Die DB hat 23 Zweiteiler der Baureihe BR 632 und 49 Dreiteiler der Baureihe BR 633 für die Einsatzgebiete Dortmund/Sauerland Dreieich bei Frankfurt am Main und Allgäu geordert Der 2012 geschlossene Rahmenvertrag hatte die Möglichkeit geboten Der deutsche Markt ist der anspruchsvollste Eisenbahnmarkt in Europa Die Zusammenarbeit mit der DB war eine Herausforderung wir hatten keine Erfahrung mit einem so anspruchsvollen Partner“ weil wegen des langwierigen 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