27 Feb 2025 20:30:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Asociacion Deportiva Tarma vs Sport Boys on Thu Predicted lineups are available for the match a few days in advance while the actual lineup will be available about an hour ahead of the match The current head to head record for the teams are Asociacion Deportiva Tarma 3 win(s) Jhonny Vidales is the competition's top scorer (6) Have scored 5 goals in their last 5 matches Have kept the most clean sheets in the competition (2) 27 Feb 2025 20:30:00 GMT?Asociacion Deportiva Tarma vs Sport Boys on Thu 27 Feb 2025 20:30:00 GMT ended in a 2–2 tie.InsightsHave scored 10 goals in their last 5 matches Asociacion Deportiva Tarma is playing home against Sport Boys at Estadio Municipal Unión de Tarma on Thu Is Peruvian forward Alejandro Hohberg on the verge of a move to Major League Soccer? If he leaves Universitario in the Peruvian Liga 1 the 28-year-old reportedly has a clause in his contract that only allows for an “immediate” MLS transfer ⚽️🎙️ @angelpaulflores: "Los representantes de Hohberg están viendo si el jugador se puede ir a jugar a la MLS, su cláusula es inmediata" @FutComoCancha @RPPNoticias pic.twitter.com/nHZWVU2QYw According to @angelpaulflores, 28-year-old Peruvian international winger Alejandro Hohberg's agent is trying to get him a move to MLS.Currently with Universitario in Peru, Hohberg has a clause in his contract that allows him to leave ONLY for an MLS club. pic.twitter.com/Rh2y2dv2N9 arrived at Universitario on a free transfer from Alianza Lima in January He’s scored four goals in the Apertura campaign and has been capped four times for La Blanquirroja making his debut against Trinidad & Tobago in a friendly win in 2016 Hohberg had a 12-minute stint off the bench in an international friendly against Uruguay in October whose grandfather is famed former Uruguayan player Juan Hohberg began his professional career in that country competing for Rentistas and CA Torque before a move to FBC Melgar in Peru in 2014 Print An Ontario egg farm is facing more than four dozen animal cruelty charges after tens of thousands of hens were found living in “inhumane” conditions and laying eggs among dead birds The San Bernardino County district attorney’s office charged Robert Hohberg and his farm on Tuesday with 39 misdemeanor counts of violating California’s Prevention of Farm Animal Cruelty Act which requires egg-laying hens to be given enough space to allow them to properly spread their wings without touching other birds or the cage and his farm also face 16 misdemeanor counts of animal cruelty He is scheduled to appear in San Bernardino Superior Court on March 7 “If you are going to harm animals here in the Inland Empire An investigation into the farm’s conditions was launched after a complaint in January 2016 to the Inland Valley Humane Society The complaint alleged that chickens were being kept in “inhumane” and “deplorable” conditions the district attorney’s animal prosecution unit the Ontario Police Department and the humane society got a warrant and searched the ranch Officials found 28,000 chickens living in unsanitary and overcrowded cages Other hens were found laying eggs among dead and decaying birds the eggs were intended for human consumption “While we are obviously concerned about the health of our citizens we also have a lawful obligation to ensure that animals in our county are being treated humanely,” Ramos said “The overcrowded conditions these animals were forced to live in were cruel In 2012, the Food and Drug Administration sent a warning letter to Hohberg after finding serious health violations at three of his facilities during inspections the farms did not have proper practices in place to prevent salmonella contamination The FDA also found that a manure scraper had not been properly disinfected Inspectors spotted at least one cat in the rows of caged chickens and wild birds inside the poultry houses A woman who answered the phone at the poultry ranch Tuesday declined to comment about the charges he faces up to 180 days in jail for each cage size violation and a year for each animal cruelty count Ramos said he is hoping the case helps prevent other ranchers in the Inland Valley “It’s not really about putting people in jail for years,” he said veronica.rocha@latimes.com Twitter: @VeronicaRochaLA California Subscribe for unlimited accessSite Map The aim of this study was to analyze the absorbed dose of 177Lu-PSMA in osseous versus lymphatic metastases in patients with metastatic castration-resistant prostate cancer across therapy cycles and to relate those data to therapeutic success pretherapeutic prostate-specific membrane antigen (PSMA) PET/CT was evaluated for its ability to predict response behavior Methods: The study comprised 30 patients with metastatic castration-resistant prostate cancer each receiving at least 3 cycles of 177Lu-PSMA therapy Prostate-specific antigen (PSA) values between baseline and 6 wk after the third therapy cycle were used to classify the patients as responders (PSA decline ≥ 50%) or nonresponders (unchanged or increasing PSA level) Quantitative SPECT/CT images were acquired 24 The absorbed dose for tumor lesions was calculated with dosimetry software the tumor-to-kidney uptake ratio was determined for different SUVs the kidneys received a mean dose of 0.55 ± 0.20 Gy/GBq per cycle the lymph node lesions received a mean dose of 3.73 ± 1.65 Gy/GBq in responders and 1.86 ± 1.25 Gy/GBq in nonresponders (P < 0.01) the respective mean doses were 3.47 ± 2.00 Gy/GBq and 1.48 ± 0.95 Gy/GBq (P < 0.01) When successive therapy cycles were compared the mean dose was found to have been reduced from the first to the second cycle by 27% for lymph nodes and by 33% for bone lesions A significant difference (P < 0.01) in the ratio of lymph node and bone lesion uptake to kidney uptake between responders and nonresponders could be deduced from the pretherapeutic PET/CT scan Conclusion: Significantly higher doses were achieved for lymph node and bone lesions in responders decreasing in the second therapy cycle thereafter despite unchanged therapy activities It may be possible to estimate the response to therapy from the ratio of tumor uptake to kidney uptake obtained from the pretherapeutic PSMA PET/CT scans different methodologic approaches were taken some studies distinguished between responders and nonresponders but not between the different types of metastatic lesions a distinction was made between lymph node and osseous metastases but the patient group was not divided into responders and nonresponders The aim of this work was to combine both approaches The patients were divided into responders and nonresponders according to their response to therapy and at the same time differences between lymph node and bone lesions were evaluated The correlation of tumor dose and therapy outcome is of course important but even more valuable would be to predict the likelihood of response before radioligand therapy by means of a marker This study investigated whether pretherapeutic PSMA PET/CT imaging could be used to predict therapy response (and hence the course of therapy) 30 patients with metastatic castration-resistant prostate cancer were enrolled in our study and underwent at least 3 cycles of 177Lu-PSMA therapy (177Lu-PSMA-I&T) All patients had undergone radical prostatectomy before 177Lu-PSMA therapy Patients with a good treatment response received up to 6 cycles Sufficient PSMA avidity for therapy was defined on 18F-PSMA-7 or 68Ga-PSMA PET/CT before the therapy To minimize renal toxicity due to impaired renal function or excretory problems 99mTc-mercaptoacetyltriglycine scintigraphy was performed before every therapy cycle This study was conducted in accordance with the requirements of the Institutional Review Board All patients gave written informed consent to receive PSMA PET/CT and radioligand therapy and imaging and to have their data included in a retrospective analysis All procedures were performed in compliance with the regulations of the responsible local authorities (District Administration of Cologne Pretherapeutic PET imaging was performed using 18F-PSMA-7 (18F-JK-PSMA-7) or 68Ga-PSMA (68Ga-PSMA-HBED-CC). The preparations of both tracers have been described previously (13,14) 18F-PSMA-7 or 68Ga-PSMA was administered to patients on a weight-adjusted basis of 5.0 MBq/kg and 2.5 MBq/kg High-purity lutetium chloride (177LuCl3) was obtained from ITG, and PSMA-I&T was purchased from ABX. 177Lu-PSMA-I&T was synthesized and labeled according to a previously published protocol (15) Patients received a mean activity of 7,209 ± 379 MBq of 177Lu-PSMA-I&T for each therapy cycle All PET/CT scans were obtained on a Biograph mCT device (mCT 128 Flow Edge; Siemens) Imaging started with a low-dose nonenhanced CT scan (120 kV slice thickness of 5.0 mm) for attenuation correction followed by a whole-body PET scan from the base of the skull to the mid thigh Reconstruction was conducted with an ordered-subset expectation maximization algorithm with 4 iterations and 12 subsets and gaussian-filtered to a transaxial resolution of 5 mm in full width at half maximum Quantitative SPECT/CT images (xSPECT; Siemens) were acquired at 24 and 168 h after application of 177Lu-PSMA-I&T on a Symbia Intevo Bold system (Siemens) The same time points were chosen for each therapy cycle If no lesions in the head region were of interest for dosimetry images of the thorax and abdomen were acquired at 2 bed positions slice thickness of 3.0 mm) was acquired alongside each SPECT scan The SPECT images were reconstructed with an ordered-subset conjugate gradient maximization algorithm the device was regularly calibrated for 177Lu according to the manufacturer’s protocol A maximum of 5 lymph node lesions or 5 bone lesions per patient that were visually suggestive of prostate cancer metastases were counted and analyzed Lesions with a volume smaller than 10 cm3 were not considered the kidneys were automatically segmented on the first CT image using an artificial intelligence algorithm (Contour Protégé AI; MIM Software) Lesions and the kidneys were resegmented for each therapy cycle in the same way All SPECT and CT datasets were automatically coregistered by multiple local rigid registrations for each region of interest The spatially aligned images are then used to calculate time–activity curves and the absorbed doses The MIM Software provides a voxel-by-voxel curve fitting and integration Curves are fitted by minimizing the squared differences between the curve from the selected function and the observed data points The curve-fitting options are trapezoid plus exponential biexponential (forced zero at uptake time 0) which finds the best fitting model from the monoexponential and biexponential options The metric used to evaluate each equation is the Akaike information criterion which evaluates the loss of information when a model is used to approximate the true distribution The lowest Akaike information criterion value corresponds to the lowest information loss and the model with the lowest Akaike information criterion is chosen on a voxel-by-voxel basis The automatically determined curve fitting was selected in each case The calculation of absorbed dose is based on the voxel S-value convolution method according to MIRD pamphlet 17 The voxel S-value convolution kernel was derived from Monte Carlo simulations with MCNP 6.2.2 The voxel S-value convolution kernels are simulated assuming the density of water for the MIRD 17 kernels a correction is necessary for tissues with heterogeneous densities The absorbed dose map was corrected for physical density by applying a physical density map derived from the CT scan with Hounsfield units being mapped to physical density values using a bilinear fit curve The Hounsfield units are derived by scanning a CT density phantom using the same CT protocol as will be used for the SPECT/CT image acquisition The resulting dose maps are divided by the physical density map providing a density-corrected absorbed dose calculation Time–activity curve and dose volume histograms were calculated for all segmented structures on a voxel-based level The same lesions and the kidneys were segmented on the corresponding pretherapeutic PET/CT scans the mean ratio of lesion uptake to kidney uptake was calculated for SUVmax An in-house workflow was created to calculate the total tumor burden (TTB) and the distribution to lymph nodes and bone lesions for each patient a bone mask containing the entire bone volume of the patient is generated on the CT scan all lesions larger than 10 cm3 are segmented The bone mask is used to separate the bone lesions from the lymph nodes all segmented standard organs are also separated from the TTB The recovery curve was fitted to apply them to arbitrary volumes Partial-volume correction was also applied for the kidneys The corresponding phantom measurements were also performed on the PET/CT scanner for 18F and 68Ga at an activity concentration of 20 kBq/mL Biochemical response assessment was based on PSA levels according to previously described protocols (19) Response was defined as a PSA decline of at least 50% and nonresponse as an unchanged PSA level or an increasing level Baseline for the PSA value was acquired on the day of therapy or the day before The last PSA value considered was 6 wk after the third therapy or on the day of the fourth therapy if this had taken place The software package SPSS Statistics 29 (IBM) was used for statistical analysis The mean absorbed doses in lymph node and bone lesions were compared between responders and nonresponders using a Mann–Whitney U test the ratio of lesion to kidney uptake was compared between responders and nonresponders Differences in absorbed dose among the 3 cycles of therapy were examined using a Wilcoxon test matched-pair signed-rank test The Kolmogorov–Smirnov test and the Shapiro–Wilk test were used to test for normality of the distributions A P value of less than 0.05 was considered statistically significant All data are expressed as the mean and related SD The change in PSA value with each cycle of therapy for each patient is listed in Supplemental Table 2 Results and details on the partial-volume correction and evaluation of the PET Edge+ tool for SPECT imaging can be found in Supplemental Tables 3 and 4 the recovery coefficient curve can be found in Supplemental Figure 1 The mean absorbed kidney dose did not differ significantly (Z = −0.73; P = 0.47) between responders (0.53 ± 0.21 Gy/GBq) and nonresponders (0.56 ± 0.20 Gy/GBq), nor did it change significantly between the separate therapy cycles (Z ≥ −0.69; P ≥ 0.44). All results for the individual therapy cycles are presented in Table 2 and Supplemental Table 5 Results for Mean Kidney Dose Divided into Responder and Nonresponder including 37 lymph node lesions and 40 bone lesions The number of lesions was evenly distributed between responders and nonresponders Individual tumor volumes used for analysis are summarized in Supplemental Table 6 the responders received a mean dose of 3.73 ± 1.65 Gy/GBq for lymph node lesions and the nonresponders 1.86 ± 1.25 Gy/GBq the mean absorbed dose for lymph nodes was reduced to 2.73 ± 1.48 Gy/GBq for responders and to 1.81 ± 1.45 Gy/GBq for nonresponders the dose dropped to 2.71 ± 1.55 Gy/GBq for responders and to 1.74 ± 1.55 Gy/GBq for nonresponders The difference between the first and second therapy cycles and between responders and nonresponders was significant (P < 0.01) A similar pattern was found for bone lesions in responders and nonresponders a mean dose of 3.47 ± 2.00 Gy/GBq was achieved for osseous metastases in responders compared with a mean dose of 1.48 ± 0.95 Gy/GBq in nonresponders responders received mean doses of 2.32 ± 0.96 Gy/GBq and 1.73 ± 0.79 Gy/GBq whereas nonresponders received 1.31 ± 0.91 Gy/GBq and 1.31 ± 0.94 Gy/GBq Mean dose for lymph node lesions differentiated between responders and nonresponders over 3 therapy cycles Mean dose for bone lesions differentiated between responders and nonresponders over 3 therapy cycles the TTB also changed over the course of therapy cycles the TTB decreased by 52.3% ± 4.7% on average the TTB decreased less or even increased again overall With regard to only the tumor volume of the lesions considered for dosimetry responders were found to have a mean decrease of 54.5% and nonresponders a mean decrease of 30.8% Already-treated lesions appeared to diminish in nonresponders while new lesions appeared The corresponding data are given in Supplemental Table 10 This evaluation was based on a total of 19 scans with 18F-PSMA-7 PET/CT and 11 with 68Ga-PSMA PET/CT and SUVmedian was equal in responders and nonresponders the SUVs for 68Ga were 36% higher than those for 18F but this applied to the kidneys and lesions alike Detailed information on the individual SUVs for 68Ga and 18F is shown in Supplemental Table 11 including the tumor-to-kidney uptake ratio and the decrease or increase in TTB Mean Dose for Lymph Node Lesions and Corresponding Lesion-to-Kidney Ratio Mean Dose for Bone Lesions and Corresponding Lesion-to-Kidney Ratio (A–C) PET/CT imaging before first therapy cycle (D–F) PET/CT imaging after 2 therapy cycles (C and F) Maximum-intensity projections together with TTB and TLG Lesions with SUV < 3.5 were not included SUVbw = standardized uptake value based on body weight Three main findings emerged from the study: responders to 177Lu-PSMA therapy achieved higher absorbed doses than nonresponders absorbed doses decreased over the 3 therapy cycles and tumor-to-kidney uptake ratio may serve as a parameter to identify potential responders on a pretherapeutic PSMA PET/CT scan Partial-volume correction for the kidneys was based on the largest sphere which does not correspond to the anatomic shape of the kidneys This represents a limitation of the kidney dose thus determined Our data suggest that the observed decrease in absorbed dose may be related to a decrease in residence time It remains unclear whether this decrease may be due to reduction or damage of PSMA receptors by the initial therapy No further dose decrease could be observed between the second and third cycles the dose achieved remained constant in both responders and nonresponders Whether this also applies to subsequent therapy cycles will be investigated in a further study no distinction was made between unchanged PSA level and PSA increase Defining an unchanged PSA value as the initial PSA value ± 10% deviation we found that 50% of nonresponders belong to this group may have influenced our measure of further disease progression Compared with other studies, only 3 measurement points were chosen for dosimetry. However, this number should be sufficiently accurate, as results with a root-mean-squared error below 10% have already been achieved in other studies with only one late measurement point (25,26) PET/CT images with 18F and 68Ga were used to assess the lesion-to-kidney ratio since no absolute SUVs but only relative ratios were compared between kidney and lesion uptake this limitation should affect the results only minimally There are multiple studies suggesting the importance of pretherapeutic PET/CT in predicting response to 177Lu-PSMA therapies (29,30). In contrast to the work of Khreish et al. (29) we cannot confirm that SUVpeak is less appropriate than SUVmean as a predictor of therapy response the tumor-to-liver uptake ratio was compared with progression-free survival in the study of Khreish et al The tumor-to-liver ratio was not available in our patient collective because some patients also had metastases in the liver In the work by Buteau et al. (30) an SUVmean of 10 or higher on PSMA PET was evaluated as a predictive biomarker for response to 177Lu-PSMA-617 would not be transferable to our collective as the SUVmean in tumor lesions was higher than 10 for responders and nonresponders the response evaluation has been based on only biochemical response with no long-term follow-up or survival data Some patients reported here received up to 6 cycles the number of these patients is still too small for a valid statistical evaluation a few tendencies are emerging for further treatment response which will also be investigated together with overall survival in the future a significantly higher dose is absorbed in responders than nonresponders during the course of radioligand therapy with 177Lu-PSMA-I&T This difference is also reflected in the therapeutic success The absorbed dose was highest in the first cycle and then decreased significantly in the second cycle for increasing the applied activity in the first cycle to maximize therapy success The significant difference in the tumor-to-kidney uptake ratio between responders and nonresponders may serve as a predictor of treatment response Further studies will be needed to examine this possibility No potential conflict of interest relevant to this article was reported QUESTION: Is there a clear difference between responders and nonresponders and is it possible to predict the response to 177Lu-PSMA therapy 30 patients with metastatic castration-resistant prostate cancer undergoing 177Lu-PSMA therapy were examined with regard to therapy response and the achieved dose for lymph nodes and bone metastases A significant difference between responders and nonresponders was found The response to therapy may be estimated from pretherapeutic PSMA PET/CT based on the lesion-to-kidney uptake ratio IMPLICATIONS FOR PATIENT CARE: An assessment of the therapy response allows other options to be considered or the applied activity to be adjusted Thank you for your interest in spreading the word on Journal of Nuclear Medicine NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it We use cookies and similar technologies that may collect information about you and your activities on our websites and share it with third parties as described in our Privacy Policy and Ad & Cookie Policy you agree to our use of cookies and similar technologies the first criminal charges were brought under California’s Prevention of Farm Animal Cruelty Act The San Bernardino County District Attorney’s Office filed more than 50 charges against an Ontario after investigations revealed chickens were being kept in cages so overcrowded the animals were unable to turn around—conditions outlawed by the Prevention of Farm Animal Cruelty Act The Prevention of Farm Animal Cruelty Act passed via state ballot initiative by a 64% majority of California voters in 2008 requires that egg-laying hens have the ability to fully spread their wings without touching another bird or the side of an enclosure In addition to 39 counts of violating the Prevention of Farm Animal Cruelty Act prosecutors also charged Hohberg Poultry Ranches with 16 counts of animal cruelty under California’s state animal cruelty code The charges stem from a 2016 investigation conducted by the Inland Valley Humane Society and the Animal Cruelty Prosecution Unit of the San Bernardino District Attorney’s Office following a complaint that hens were being kept in “inhumane” and “deplorable” conditions According to Deputy District Attorney Debbie Ploghaus who oversees the Animal Cruelty Prosecution Unit: we found approximately 28,800 hens in unsanitary conditions that clearly violated the Farm Animal Cruelty Act we found dead hens decaying in the same cages beside living hens laying eggs for human consumption.” Hohberg Poultry Ranches received a warning letter from the Food and Drug Administration in 2012 after serious human health violations were found during inspections San Bernardino County District Attorney Michael Ramos “While we are obviously concerned about the health of our citizens we also have a lawful obligation to ensure that animals in our county are being treated humanely The overcrowded conditions these animals were forced to live in were cruel who created the Animal Cruelty Prosecution Unit just under a year ago told local news station ABC7 the egg facility was in clear violation of the law saying of the cramped conditions endured by the birds: “I think it’s horrendous They start trying to get out and they start pecking one another It’s just a horrendous situation.” pled not guilty to all charges at his March 7 arraignment in San Bernardino Superior Court he could face up to 180 days in jail for each cage size violation and one year for each animal cruelty count efforts to prevent the most egregious forms of cruelty to farmed animals with the 2008 passage of the Prevention of Farm Animal Cruelty Act which mandated that animals be housed in conditions that allow them enough space to turn around freely The law has thus far withstood multiple challenges from the agriculture industry when the Ninth Circuit Court of Appeals upheld a lower court’s dismissal of a lawsuit brought by six states that argued provisions in California’s law violated the Commerce and Supremacy Clauses of the U.S The Animal Legal Defense Fund is also working to ensure the California animal agriculture industry is held accountable to the state’s improved housing standards for farmed animals we sued the California Department of Food and Agriculture (CDFA) for violating the California Public Records Act by unlawfully withholding records regarding living conditions of egg-laying hens in factory farms We requested these records in August 2016 to determine factory egg farms’ compliance with California’s Prevention of Farm Animal Cruelty Act and the Shell Egg Food Safety Regulations that were instituted after its passage California residents who voted to pass the Prevention of Farm Animal Cruelty Act have a compelling interest in ensuring the law is enforced and there is little information currently available regarding egg producers’ compliance with the new standards the Animal Legal Defense Fund is leading the charge to reform factory farming through the courts in part by advocating for greater transparency and against Ag-Gag laws which are designed to prevent the public from learning about animal cruelty by criminalizing whistleblowers who reveal animal abuse Although the mistreatment of farmed animals is often hidden from public view consumers are increasingly aware of the substandard conditions in which animals raised for food are routinely kept prior to their slaughter due in part to undercover investigations by animal protection organizations Massachusetts voters overwhelmingly approved Question 3 which is similar to California’s Prevention of Farm Animal Cruelty Act California’s law bans the sale of eggs from hens kept in cages too small for them to stand up but Massachusetts is the first state to ban the sale of meat products as well as eggs from animals confined in this manner this new legislation—which passed by a landslide with 78 percent of voters in favor of the law—will be stronger than any similar law in the U.S even the strongest laws are meaningless without enforcement and prosecutors have historically been reluctant to pursue cruelty charges involving farmed animals The San Bernardino County District Attorney’s Office’s willingness to bring these animal cruelty charges and hold the agriculture industry accountable to the minimal standards enacted by California voters sends a clear message that times are changing The Animal Legal Defense Fund named District Attorney Michael Ramos one of the Top 10 Animal Defenders for 2017 undergraduate enrollment across the nation increased for the first time since the pandemic according to the National Student Clearinghouse While many colleges across the nation are seeing their student bodies grow the Fashion Institute of Design & Merchandising is not one of them The downtown-based school recently laid off 95 employees due to declining enrollment on top of a further 322 employees that were let go in the fall FIDM had also been pursuing an acquisition of its business operations by the Skema Business School an educational institution based in France Skema quietly terminated the impending deal after deciding that requirements from the U.S FIDM is a specialized private college founded in 1969 While the school previously offered an array of fashion and design programs it is transitioning to a focus on the business management and marketing side of the creative industries and the school previously had additional campuses in San Francisco The school reported that it had 1,381 full-time students enrolled in the fall of 2022 This is down 58% from its enrollment of 3,288 full-time students in fall 2012 according to the National Center for Education Statistics As part of an ongoing effort to cut its operating budget FIDM closed its three satellite campuses between 2020 and 2021 which the accrediting agency said contributed to the institution’s enrollment declines According to a notice filed with the state’s Employment Development Division FIDM’s recent layoffs include 44 instructors five department chairs and three vice presidents executive director of human resources at FIDM said to the EDD that the layoffs are expected to occur on June 17 and attributed them to “business conditions.” according to FIDM advisory board member Angela Hawekotte are based on the school’s decline in student enrollment a decline in enrollment dictates the need for fewer staff and faculty to service the students,” Hawekotte said Skema Business School announced it had entered exclusive negotiations to purchase FIDM in its entirety in a deal that was expected to close in “early 2024.” As part of the acquisition Skema students would have been able to “enjoy new academic and immersive experiences in Los Angeles,” while FIDM students in select programs would have had access to disciplines taught at Skema FIDM would have been renamed as the “Skema Business School L.A.”  FIDM vice president of education Barbara Bundy said the school was “very excited” by Skema’s interest “We are convinced that the mutual quest for excellence of our two institutions could give FIDM students new aspirations and avenues of employability in a rapidly expanding global industry,” Bundy said Skema recently announced that it had decided to stop pursuing the transaction FIDM has made no apparent public announcement on the deal’s cancellation Hawekotte said that the school was informed the day before the deal’s anticipated March 1 closure date that Skema was backing out Skema stated that the decision was based on its findings during the legal period of analysis of the information provided by FIDM that “several material conditions” had not been met Hawekotte said FIDM had fulfilled its end of the deal “While FIDM had performed all it was required to do under the proposed transaction apparently the Department of Education’s requirements of Skema to operate an educational institution in the United States were untenable to Skema,” Hawekotte said in order for Skema to have federal student loans made available to its students after the acquisition it was required by the Department of Education to provide a collateralized letter of credit to produce its French entity’s financial statements and to have those statements prepared and audited according to U.S Skema did not respond to a request for comment When FIDM laid off 322 employees in the fall it told the EDD that it anticipated a “substantial percentage” of those individuals would be offered new employment at Skema following the change in control That wave of layoffs affected 225 faculty members seven department chairs and five counselors The EDD was told that although those employees would “most likely will retain their jobs under new ownership,” that decision would be made by Skema “The October (report) was in contemplation of the Skema transaction it assumed termination and possible rehiring,” Hawekotte said “(FIDM will) do what is necessary in order to meet its obligations to teach its students.” FIDM did not clarify whether its steps to meet those obligations will entail rehiring any staff or if the school expects further layoffs following the deal’s cancellation FIDM’s accreditation is overseen by a non-governmental regional agency called the WASC Senior College and University Commission the commission granted FIDM initial accreditation as a baccalaureate institution – the school was previously accredited as an offeror of associate degrees and two-year programs in 1978 and as an arts program provider in 2003 The commission commended FIDM at the time for assets such as its support for student learning A 2018 accreditation review flagged FIDM’s long-term financial viability as a significant issue and the university commission stated that FIDM’s institutional leadership had moved slowly to take the necessary steps to cut costs and to find new ways to increase enrollment and revenue FIDM’s gross revenue was $44.2 million in fiscal-year 2022 FIDM was placed on accreditation probation in July 2021 after continuing to not meet the commission’s standards Students who attend unaccredited schools do not have access to federal financial aid and some graduate schools and employers may not acknowledge degrees from unaccredited programs “The financial sustainability of FIDM was noted as a major concern by the commission after the 2018 accreditation review particularly related to persistent declines in enrollment that have resulted in reductions in revenue and net income,” the commission said in its 2021 report despite significant cuts to the operational budget and the sale of a significant asset.” The probationary period gave FIDM two years to address its decade-long drop in enrollment and its budgetary deficits although the Covid-19 pandemic fed into those issues its problems had preceded the pandemic by some time FIDM predicted in 2021 that its financial deficits would continue for “at least three more years,” despite cutting its operating budget by about $10 million  “It is imperative that FIDM create and implement a concrete resource and development plan that includes realistic budgeting enrollment management and diversification of revenue sources,” the organization wrote in 2021 the commission said that FIDM had improved in several areas but still had not provided “evidence of long-term financial viability.” If the issue was not remedied prior to the probation period’s expiration in July the organization said it would take the “adverse action” of withdrawing FIDM’s accreditation about a month after receiving that warning FIDM announced a financial agreement with Arizona State University An ASU spokesperson said that this agreement involves ASU purchasing FIDM’s downtown location at 919 S and the rights to the adjacent Grand Hope Park ASU is also buying the “intrinsic rights” to FIDM’s intellectual property FIDM design students will now be offered transfer options to ASU and ASU’s fashion education programs will be renamed ASU FIDM According to reporting from the Los Angeles Times an undisclosed number of FIDM fashion programs may be discontinued as a result and the surprising nature of the announcement left many students “in the lurch.” FIDM will continue to operate as a separate education institution from ASU and the college itself is still owned by FIDM founder and president Tonian Hohberg Upon the plan’s expected completion at the end of June FIDM will no longer “be responsible” for its fashion and design students and will instead focus on the “business-oriented” side of the creative industries This will include degrees in product development digital marketing and international manufacturing graphic design and creative industry studies will be offered through the ASU Herberger Institute for Design and the Arts FIDM did not respond to request for comment on whether it will continue to have any connection with students who were previously enrolled in its fashion and design programs While the agreement with ASU has caused stress for some students it was a profitable solution for FIDM’s continuing financial stresses The WSCUC reported that the sale relieved FIDM of the operating costs of the building and is anticipated to result in “significant cost savings” for the school the WSCUC removed FIDM from probation and commended the school for its strong brand and reputation its “diligent” work on the ASU agreement and its improved transparency and communication The ending of its probation had a few provisions including the need for FIDM to prove that the elimination of its long-term debt through escrow has been achieved The commission previously stated in 2021 that FIDM’s long-term debt of $28 million was scheduled to mature this year Prior to its cancelled acquisition by Skema FIDM’s next review by the WSCUC was set to be held this fall that timing is up in the air as the accreditation institution evaluates the situation “WSCUC is revising FIDM’s institutional assessment schedule and evaluating next steps in light of the changed circumstances,” WSCUC president Jamie Studley told the Business Journal “WSCUC will evaluate FIDM’s accreditation status at that time and the institution’s structural-change proposal Hawekotte said the university will do what is necessary to teach its students and emphasized that its accreditation is independent of Skema FIDM did not respond to request for comment on whether the school is looking for a new third-party buyer or any forecasts for fall enrollment this year “We continue to work with (WSCUC) as we navigate our future without the Skema transaction,” Hawekotte said Learn how to describe the purpose of the image (opens in a new tab) Leave empty if the image is purely decorative « Back Metrics details Soil invertebrates are among the least understood metazoans on Earth the lack of taxonomically broad and dense genomic resources has made it hard to thoroughly investigate their evolution and ecology With MetaInvert we provide draft genome assemblies for 232 soil invertebrate species representing 14 common groups and 94 families We show that this data substantially extends the taxonomic scope of DNA- or RNA-based taxonomic identification we confirm that theories of genome evolution cannot be generalised across evolutionarily distinct invertebrate groups The soil invertebrate genomes presented here will support the management of soil biodiversity through molecular monitoring of community composition and function and the discovery of evolutionary adaptations to the challenges of soil conditions In addition to serving taxonomic identification broad (many distinct groups) and dense (many species from a group) sequencing of genomes additionally allows identifying common patterns of gene evolution and test the taxonomic generality of hypotheses on genome evolution The genome assembly pipeline consists of a read quality filtering step, short read assembly and several steps for removing non-target DNA reads, co-sequenced along the genomes of the targeted species. The MetaInvert logo was created by the first author. Animal silhouettes originate from phylopic.org, and they can be reused under Creative Common licences. Center line: median; box limits: upper and lower quartiles; whiskers: 1.5× interquartile range; points: outliers Differences in vegetation are known to influence soil invertebrate community composition although our analysis may lack power to equivocally detect these Differences in community composition between the study years may reflect year-specific environmental differences we caution not to over interpret these results The power of an analysis of drivers of community composition and richness on this gradient should be increased with more extensive sampling The analyses nonetheless demonstrate the value of a dedicated soil invertebrate genome database for the identification of shotgun-sequenced environmental nucleotide samples from soils a Initial SEM with hypothesised links; b–f SEMs fitted to all taxa Arrows indicate hypothesised or modelled relationships Links marked with grey arrows were not statistically significant in the SEM Fisher’s C evaluates conditional independence claims among nodes and indicates model fit with p-values showing whether discrepancies between the model and the data are statistically significant Values next to arrows show standardised estimates with asterisk indicating the statistical significance of the relationship (*p < 0.05 Animal silhouettes originate from phylopic.org and they can be reused under Creative Common licences This link might also originate from the expansion of repeats with low GC content models of oribatids and Collembola suggested that higher habitat generality might be linked to lower repeat contents lineage-specific view of factors driving genome size evolution rather than the classical view of only a few general factors governing the C-value enigma the taxonomically broad and dense sampling of genomes provides unique insights into genome evolution although clearly not into structural differences Here we could show that no single theory of genome evolution fits all taxa: there are probably no simple overarching explanations for observed variations in genome properties but interactions of multiple drivers result in divergent genome evolution patterns in different groups reflecting their unique evolutionary history Broad genome sampling allows for the identification of group-specific gene loss patterns highlighting issues and future directions around the functional annotation of genomes from non-model taxa in diverse habitats the 232 soil invertebrate genomes demonstrate the importance of genome sequencing efforts for understanding the ecology and evolution of the full scale of eukaryotic biodiversity and project a future when maximum taxonomic and functional information will be gained from every environmental DNA or RNA fragment the MagAttract High Molecular Weight DNA Kit (Qiagen Voucher specimens are deposited in the Senckenberg museum collection in Görlitz our initial sequencing efforts targeted 2 gigabase (Gb) per species We increased efforts to 10 Gb per species as sequencing became more affordable For most of the reported genomes we obtained ~10 Gb per species where every gene in the BUSCO set is expected to be present once in each member species We searched for BUSCO genes in our final assemblies as a quality indicator of genome assembly completeness we used the most specific BUSCO database that was available for each of the invertebrate groups (nematoda_odb10 BUSCO genes for nematode assemblies We selected the genome assembly with the highest percentage of complete BUSCO genes as the species representative if more than a single replicate per species was available This resulted in a total of 232 genome assembly drafts used for downstream analyses and has no downstream consequences for our analyses the main non-sequencing method of genome size estimation we first plotted the distribution of sequencing coverage across each genome and visually inspected each plot for the mode coverage (the highest point of the peak) If a genome assembly did not have a clearly discernible peak in sequencing coverage then genome size was not estimated for this species genome size was estimated by dividing the total mapped bases by the mode coverage We performed the path analyses for all taxa together (linear mixed effect models with soil invertebrate groups as random variable) and separately for each of the more densely sampled taxa (Collembola Reproduction mode was included only into the models of all taxa and of oribatids as this data were limited in the other groups after visual inspection of the ortholog profiles we were able to identify patches of core metazoan genes which were missing from certain groups 1482 core metazoan genes were assigned to their ontology group(s) the two gene lists of interest (50 genes missing from the 78 Collembola species; 97 genes missing from the 54 Oribatida species) were separately tested for any significant enrichment of genes belonging to any of the three gene ontology groups (biological process Significant enrichment of a gene ontology term in the missing genes was stated when the category was represented by more than five genes in the list of 1482 core metazoan genes and with a significant over-representation in a Fisher’s exact test (p < 0.05) we manually screened putative functions associated with genes missing from Collembola and Oribatida assemblies in the UniProt database (accessed on 28.6.2023) aiming to identify functional or other relevant commonalities which might be missed by an algorithmic GO enrichment analysis The mean empirical probability of not being able to detect a particular gene in a taxon was 0.22 for all OMA genes excluding those missing in springtails and oribatids So this is also the probability of not finding a particular OMA gene in the genome of a new taxon The probability that it is actually present in the majority of the taxa if it is also not found in the second sequenced species drops to 0.05; already in the third species in which the gene is not found the probability that the gene is actually present in the majority of the species of the taxon is below the significance level Genome analyses are based on Illumina genomes of 232 soil invertebrate species Genome sizes could be estimated for 191 species Metatranscripomic assignment was performed on 10 soil RNA samples Structural equation models were fitted on genome properties of 143 taxa Genomes of 177 species were assessed for the presence of core metazoan genes.Tests of normal distribution were performed to ensure that assumptions of regression are fulfilled for the structural equation models Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article FAO, ITPS, GSBI, CBD & EC. 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Supplementary Data to MetaInvert. https://doi.org/10.6084/m9.figshare.24435052.v1 and microorganism distribution patterns along an alpine to nival elevation gradient ModEst: accurate estimation of genome size from next generation sequencing data Drift-barrier hypothesis and mutation-rate evolution Genome size evolution: towards new model systems for old questions Squamate reptiles challenge paradigms of genomic repeat element evolution set by birds and mammals Coordination of Information on the Environment (CORINE) The Unified Neutral Theory of Biodiversity and Biogeography Prediction and estimation of effective population size The impact of transposable elements on eukaryotic genomes: from genome size increase to genetic adaptation to stressful environments Repeated big bangs and the expanding universe: directionality in plant genome size evolution Base composition bias might result from competition for metabolic resources Metabolic flexibility allows bacterial habitat generalists to become dominant in a frequently disturbed ecosystem Does Habitat Affect the Genomic GC Content A Lesson from Teleostean Fish: A Mini Review In Fish Ecology 61–80 (Nova Science Publishers Environments shape the nucleotide composition of genomes Relative amino acid composition signatures of organisms and environments The C-value enigma and the evolution of eukaryotic genome content Dynamics of genome size evolution in birds and mammals Satellite DNAs between selfishness and functionality: structure genomics and evolution of tandem repeats in centromeric (hetero)chromatin Structural and functional liaisons between transposable elements and satellite DNAs Latitudinal variation in genome size in crustaceans Genome size variation is associated with life-history traits in birds Genome evolution in filamentous plant pathogens: why bigger can be better Tuning environmental timescales to evolve and maintain generalists A genomics approach reveals insights into the importance of gene losses for mammalian adaptations Widespread patterns of gene loss in the evolution of the animal kingdom Pyridine: the scaffolds with significant clinical diversity Evolutionary ecology of beta-lactam gene clusters in animals Two high-quality de novo genomes from single ethanol-preserved specimens of tiny metazoans (Collembola) Beyond DNA barcoding: the unrealized potential of genome skim data in sample identification Improved funnel-type extractors for soil arthropods DNA extraction from dry museum beetles without conferring external morphological damage The D3-D5 region of large subunit ribosomal DNA provides good resolution of German limnic and terrestrial nematode communities Single-tube library preparation for degraded DNA Trimmomatic: a flexible trimmer for Illumina sequence data Improved metagenomic analysis with Kraken 2 SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing Fast and sensitive protein alignment using DIAMOND Redundans: an assembly pipeline for highly heterozygous genomes Spatial patterns of pathogenic and mutualistic fungi across the elevational range of a host plant High throughput sequencing combined with null model tests reveals specific plant-fungi associations linked to seedling establishment and survival thousands of taxa: microbial community structure and associations analyzed via marker genes mvabund– an R package for model-based analysis of multivariate abundance data R: A Language and Environment for Statistical Computing MAFFT multiple sequence alignment software version 7: improvements in performance and usability FASconCAT: convenient handling of data matrices ClipKIT: A multiple sequence alignment trimming software for accurate phylogenomic inference IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era Phylogenomics resolves the timing and pattern of insect evolution ggtree: an R package for visualization and annotation of phylogenetic trees with their covariates and other associated data Treeio: an R package for phylogenetic tree input and output with richly annotated and associated data Colorspace: a toolbox for manipulating and assessing colors and palettes Review of extra-embryonic tissues in the closest arthropod relatives The phylogeny and evolutionary history of arthropods tardigrades and insights into the evolution of segmentation mlRho - a program for estimating the population mutation and recombination rates from shotgun-sequenced diploid genomes RepeatModeler2 for automated genomic discovery of transposable element families a database of repetitive elements in eukaryotic genomes Smit, A., Hubbley, R. & Green, P. RepeatMasker Open 4.0. http://www.repeatmasker.org (2015) piecewiseSEM: piecewise structural equation modelling in r for ecology PhyloProfile: dynamic visualization and exploration of multi-layered phylogenetic profiles InterProScan 5: genome-scale protein function classification Alexa, A. & Rahnenfuhrer, J. topGO: Enrichment Analysis for Gene Ontology v2. https://doi.org/10.18129/B9.bioc.topGO (2022) Download references Open Access funding enabled and organized by Projekt DEAL Senckenberg Biodiversity and Climate Research Centre LOEWE Centre for Translational Biodiversity Genomics Centre de Recherche en Biomédecine de Strasbourg Rhineland-Palatinate Technical University Kaiserslautern Landau Ljudevit Luka Boštjančić & Kathrin Theissinger Institute of Cell Biology and Neuroscience Department of Forest Mycology and Plant Pathology Swedish University of Agricultural Sciences The authors declare no competing interests This manuscript was previously reviewed at another Nature Portfolio journal Communications Biology thanks the anonymous reviewers for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s42003-023-05621-4 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Anthropocene newsletter — what matters in anthropocene research 18F-prostate-specific membrane antigen (PSMA)-1007 is excreted mainly through the liver We benchmarked the performance of 18F-PSMA-1007 against 3 renally excreted PSMA tracers we selected 27 in whom PET/CT results obtained with 68Ga-PSMA-11 18F-DCFPyL (2-(3-(1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) Juelich-Koeln) were interpreted as equivocal or negative or as oligometastatic disease (PET-1) a second PET scan with 18F-PSMA-1007 was performed (PET-2) The confidence in the interpretation of PSMA-positive locoregional findings was scored on a 5-point scale first in routine diagnostics (reader 1) and then by an independent second evaluation (reader 2) Discordant PSMA-positive skeletal findings were examined by contrast-enhanced MRI 18F-PSMA-1007 facilitated the interpretability of 27 locoregional lesions the clinical readout led to a significantly lower number of equivocal locoregional lesions (P = 0.024) and reader 2 reported a significantly higher rate of suspected lesions that were falsely interpreted as probably benign in PET-1 (P = 0.023) we observed a total of 15 PSMA-positive spots in the bone marrow of 6 patients (22%) None of the 15 discordant spots had a morphologic correlate on the corresponding CT scan or on the subsequent MRI scan 18F-PSMA-1007 exhibits a significantly higher rate of unspecific medullary spots (P = 0.0006) Conclusion: 18F-PSMA-1007 may increase confidence in interpreting small locoregional lesions adjacent to the urinary tract but may decrease the interpretability of skeletal lesions Most of the currently available PSMA tracers used for PET/CT imaging are excreted through the kidneys thus leading to a high background signal in the urinary tract It can therefore occasionally be difficult to differentiate between urine retention in the ureter and small adjacent pelvic lymph nodes This ambiguity limits the reader’s confidence in interpreting small PSMA-positive lesions close to the urinary tract as tumor relapse local recurrence close to the urinary bladder can easily be confused with urinary activity Resolving this intrinsic limitation would bring us a step further toward exploiting the full potential of PSMA tracers we present an intraindividual comparison of 18F-PSMA-1007 with 68Ga-PSMA-11 We compared the readers’ confidence in interpreting PSMA-positive lesions as tumor lesions focusing on the interpretability of locoregional lesions near the urinary tract we evaluated the performance of 18F-PSMA-1007 in the whole-body PET scan Most patients (23/27) were referred for PET/CT imaging because of biochemical recurrence according to the following criteria: a prostate-specific antigen (PSA) increase to 0.2 μg/L or more after prostatectomy (R0 or R1 resection) and a PSA increase of at least 2.0 μg/L above the nadir after radiotherapy One patient had a persistent PSA level after prostatectomy we included 2 patients with oligometastatic disease and 1 patient with secondary neoplasia (rectal cancer) for tissue differentiation None of these patients received androgen deprivation therapy The PSMA-positive lesions in PET-1 and PET-2 were localized in these irradiated regions we found the PSMA-positive PET findings plausible This observational study was approved and conducted in compliance with the Institutional Review Board All patients gave their written informed consent to PET imaging and inclusion of their data in a retrospective analysis Patients with relapsed prostate cancer underwent PET/CT imaging with one of our routinely used PSMA tracers A second PET/CT scan with 18F-PSMA-1007 was performed in 27 cases (average age 67.2 ± 7.8 y) for 1 of the following 3 reasons: the first PET scan was completely PSMA-negative; the first PET scan exhibited a PSMA-positive spot near the ureter or bladder that was interpreted as equivocal; or the first PET scan revealed a single suspected lesion before metastasis-directed therapy (e.g. The second PSMA PET/CT scan with 18F-PSMA-1007 PET/CT was performed within 3 wk after the first scan The 27 patients were selected from an overall group of 668 patients who received PSMA PET/CT within the 12-mo period of recruitment from April 2017 to March 2018 More details on patient characteristics are given in Supplemental Table 1 we acquired 18F-PSMA-1007 scans 2 h after tracer injection with an average dose of 343 ± 49 MBq All images were acquired on a Biograph mCT 128 Flow PET/CT scanner (Siemens Healthineers) The same filters and acquisition times (flow motion bed speed of 1.5 mm/s) were used for the 4 PSMA ligands Images were reconstructed using an ultra-high-definition algorithm Equivocal PSMA-positive lesions in the bone marrow were examined by dedicated MRI was performed on 1.5-T and 3.0-T MR scanners (Achieva and Ingenia; Philips Healthcare) using the clinical standard protocol by application of 0.1 mmol of gadolinium-DOTA per kilogram of body weight (Clariscan; GE Healthcare) sagittal short T2-weighted inversion recovery (STIR) sagittal T1-weighted imaging before and after contrast injection and postprocessing subtraction and sequential transversal T2-weighted and T1-weighted spectral presaturation with inversion recovery transversal diffusion-weighted whole-body imaging with background body signal suppression coronal T1-weighted imaging before and after contrast injection and transversal T1-weighted multiple-echo Dixon fat suppression Statistical analyses were performed with Microsoft Excel, the R programming language, and the programs on vassarstats.net We used the Fisher exact test (2 × 2 contingency tables) the Freeman–Halton extension (3 × 2 contingency tables) of the Fisher exact test and the Wilcoxon signed-rank test to compare groups we combined categories 1 (almost certainly benign) and 2 (likely benign) as well as categories 4 (likely malignant) and 5 (almost certainly malignant) to obtain 3 × 2 contingency tables The interobserver variability was tested by the weighted Cohen κ-test We performed 18F-PSMA-1007 PET on 27 patients who had been examined with 68Ga-PSMA-11 (n = 16), 18F-DCFPyL (n = 5), or 18F-JK-PSMA-7 (n = 6) less than 3 wk previously (Figs. 1–3; Supplemental Figs the first PET exam did not reveal any locoregional lesions the second scan with 18F-PSMA-1007 was negative in the locoregional region as well (7 patients were entirely negative one patient had an additional PSMA-positive bone marrow lesion on PET-1 and PET-2) 18F-JK-PSMA-7 PET/low-dose CT (A and C) and 18F-PSMA-1007 PET/low-dose CT (B and D) images in patient 21 Histologically confirmed PSMA-positive lesion in right seminal vesicle is shown in Supplemental Figure 1 Osteomedullary spots with 18F-PSMA-1007 in left os ilium (red arrows in B and D) and in left femur (orange arrow in B) did not have any correlate on MRI scan (E and F) Salvage prostatectomy produced excellent PSA response DWIBS = diffusion weighted whole body imaging with background body signal suppression; mDIXON FS = multiple-echo Dixon fat suppression 18F-DCFPyL PET/low-dose CT (A and C) and 18F-PSMA-1007 PET/low-dose CT (B and D) images in patient 13 PSMA-positive intraprostatic lesions in left and right lobes of prostate are visible with both 18F-DCFPyL and 18F-PSMA-1007 (green arrows) Osteomedullary spots in thoracic spine (T3 red arrows) did not have any correlate on MRI scan (E and F) Hemangioma in C3 was PSMA-negative (blue arrow) and E) and 18F-PSMA-1007 PET/low-dose CT (B Maximum-intensity projections with 18F-JK-PSMA-7 and 18F-PSMA-1007 show 2 PSMA-positive right iliac lymph nodes and PSMA-positive relapse below bladder 18F-PSMA-1007 PET scan in B shows further relapse at junction between bladder and urethra Osteomedullary spots in cervical spine (C3 dashed red arrows in B and D) and thoracic spine (T5 solid red arrows in B and F) did not have any correlate on MRI scan (G and H) suggesting that 18F-PSMA-1007 enhanced the confidence in interpretation of locoregional PSMA-positive lesions for both independent readers Contingency Table of PSMA-RADS Results for Lesions Confirmed as True-Positive for Locoregional Relapse The 18F-PSMA-1007 PET scan (PET-2) resulted in almost perfect agreement (к = 0.95 whereas the interpretation of PET-1 led to moderate agreement between the clinical readout and reader 2 (к = 0.49; weighted Cohen kappa) The data are shown in Supplemental Table 2 We next examined which aspects might have contributed to this improved interpretability both readers corrected 2 false-positive PET-1 interpretations of pelvic PSMA spots (no 2 and 24; Supplemental Table 1) that were PSMA-negative on PET-2 the signal (SUVmax) of the 24 PSMA-positive lesions was significantly higher (P = 0.00178 Wilcoxon signed-rank test) on the PET-2 scan (average SUVmax 23.37 ± 25.92) than on the corresponding PET-1 scan (SUVmax When we compared the signal between tracers separately solely the difference between 68Ga-PSMA-11 and 18F-PSMA-1007 reached statistical significance (SUVmax The differences between 18F-DCFPyL and 18F-PSMA-1007 (SUVmax as well as 18F-JK-PSMA-7 and 18F-PSMA-1007 (SUVmax showed a similar trend but did not reach statistical significance The PSMA-positive lesions in the 19 patients were confirmed by histology in 5 patients Follow-up data were not available for 2 patients Further data for verification are presented in Supplemental Table 1 We next compared the interpretability of osteomedullary PSMA-positive lesions 18F-PSMA-1007 detected a significantly higher number of PSMA-positive bone marrow findings than did the other 3 tracers: although we identified 3 PSMA-positive bone marrow lesions on PET-1 (3/27 patients) 18F-PSMA-1007 revealed a total of 18 PSMA-positive spots in 7 of 27 patients 4 patients exhibited only discrepant findings 2 patients showed a combination of consistent and discrepant findings and 1 patient had a concordant PSMA-positive skeletal lesion Discordant results in the bone marrow were observed across all 3 tracers used for comparison (68Ga-PSMA-11 The 3 PSMA-positive bone marrow lesions on PET-1 (68Ga-PSMA-11: SUVmax 5.18 ± 0.79) were also present on the corresponding scans with 18F-PSMA-1007 (SUVmax these 3 lesions had a morphologic correlate on the corresponding CT scan (2 patients) or on a subsequent MRI scan (1 patient) none of the 15 findings that were exclusively detected with 18F-PSMA-1007 had a morphologic correlate on the corresponding CT scan Because of this lack of a morphologic correlate on the CT scan both readers interpreted these 15 additional PSMA-positive spots as equivocal (PSMA-RADS-3) although they had a high signal on the PET scan which was 7.07 ± 2.52 and 4.11 ± 2.91 times higher than the baseline SUVmax measured in the femoral head and in the thoracic aorta This discrepancy resulted in a significant difference in PSMA-RADS categories between PET-1 and PET-2 (P = 1.2893 × 10−8 Freeman–Halton extension of the Fisher exact test) and a significantly higher rate of equivocal findings (P = 0.0006 These lesions were subsequently double-checked through contrast-enhanced MRI All of these MRI scans were interpreted as showing no suggestive findings in the bone marrow regions Our direct comparison of a first PET scan with 68Ga-PSMA-11 or 18F-JK-PSMA-7 with a second PET scan with 18F-PSMA-1007 led to 3 major observations 18F-PSMA-1007 increased the readers’ confidence in interpreting locoregional PSMA-avid lesions near the ureter or the urethra as tumor tissue when the previous PET scan with 68Ga-PSMA-11 18F-PSMA-1007 PET imaging decreased the frequency of equivocal interpretations (routine diagnostics reader 1) or false-benign results (reader 2) Possible explanations are the lower background noise of 18F-PSMA-1007 in the urinary tract and the higher signal of 18F-PSMA-1007 in the locoregional lesions Although we observed this trend for all 3 tracers used for comparison the difference in 18F-PSMA-1007 signal reached statistical significance solely in comparison to 68Ga-PSMA-11 (applies to 16/27 patients in our study cohort) suggesting that the 18F label with its higher activity dose contributed more to our observation than ligand-specific factors or 18F-JK-PSMA-7 was completely PSMA-negative in the pelvis an additional PET scan with 18F-PSMA-1007 did not reveal any additional locoregional PSMA-positive lesions Because all PSMA tracers examined in this study bind to the same protein domain imaging with a second PSMA tracer cannot compensate for a lack of PSMA overexpression Our direct comparison between 68Ga-PSMA-11 and 18F-JK-PSMA-7 in PET-1 and 18F-PSMA-1007 in PET-2 was not designed as a prospective clinical trial Readers were not masked to the PSMA PET tracer and we observed a relevant interobserver variability between readers 1 and 2 in the interpretation of PET-1 (weighted Cohen к = 0.49) Our observations were focused on a highly selected cohort of 27 patients from an overall group of 668 patients (4.0%) who underwent PSMA PET/CT during the recruitment period of 1 y A second PSMA PET scan with 18F-PSMA-1007 was performed only when clinically indicated mainly because of an equivocal or negative interpretation of the first PET scan Establishing a preferred PSMA tracer will require independent validation in larger cohorts Our study suggests that the choice of the right PSMA tracer depends on the clinical context 18F-PSMA-1007 may increase confidence in interpreting small locoregional lesions adjacent to the urinary tract and may thus help to reduce equivocal interpretations in selected patients 18F-PSMA-1007 exhibits unspecific PSMA tracer accumulation in the bone marrow in a relevant number of patients skeletal lesions detected with 18F-PSMA-1007 require verification such as through MRI or simultaneous PET/MRI Imaging with 18F-PSMA-1007 may therefore be applicable primarily to patients with a high probability of locally restricted disease or as a follow-up test in cases with equivocal findings adjacent to the urinary tract When one is searching for distant metastases or 18F-JK-PSMA-7 may be more suitable because of their higher specificity in the bone marrow and Alexander Drzezga have applied for a patent on 18F-JK-PSMA-7 No other potential conflict of interest relevant to this article was reported QUESTION: Does 18F-PSMA-1007 exhibit a higher sensitivity for subtle differences near the urinary tract than other established PSMA tracers PERTINENT FINDINGS: 18F-PSMA-1007 facilitated the interpretability of locoregional PSMA-positive lesions compared with the other established PSMA PET tracers The number of equivocal and false-benign interpretations decreased significantly for 2 independent readers 18F-PSMA-1007 exhibited a substantial number of unspecific findings in the bone marrow IMPLICATIONS FOR PATIENT CARE: Because of the high tracer signal of the unspecific skeletal 18F-PSMA-1007 spots reader training alone will not solve this problem skeletal lesions detected with 18F-PSMA-1007 PET without a correlate in the corresponding CT scan require an additional examination expressed by most prostate carcinomas (PCa) The application of PSMA-specific 18F-labeled PET probes such as 18F-DCFPyL and 18F-PSMA-1007 considerably improved the accuracy of PCa tumor detection there remains a need for further improvements in sensitivity and specificity The aim of this study was the development of highly selective and specific PSMA probes with enhanced imaging properties Methods: Eight novel 18F-labeled PSMA ligands were prepared Their cellular uptake in PSMA-positive LNCaP C4–2 and PSMA-negative PC-3 cells was compared with that of 18F-DCFPyL The most promising candidates were additionally evaluated by small-animal PET in healthy rats using PSMA-positive peripheral ganglia as a model for small PCa lesions PET images of the ligand with the best outcome and 68Ga-PSMA-11 with respect to key image-quality parameters for the time frame 60–120 min 18F-JK-PSMA-7 demonstrated increased PSMA-specific cellular uptake Although target-to-background ratios of 18F-DCFPyL and 18F-PSMA-1007 were comparable this parameter was higher for 18F-JK-PSMA-7 and lower for 68Ga-PSMA-11 Image acutance was significantly higher for 18F-JK-PSMA-7 and 18F-PSMA-1007 than for 18F-DCFPyL and 68Ga-PSMA-11 Image resolution was similar for all 4 tracers 18F-PSMA-1007 demonstrated significantly higher blood protein binding and bone uptake than the other tracers Conclusion: 18F-JK-PSMA-7 is a promising candidate for high-quality visualization of small PSMA-positive lesions Excellent preclinical imaging properties justify further preclinical and clinical studies of this tracer Previously known PSMA-specific PET tracers (68Ga-1 and 18F-3) and emerging probes (18F-JK-4-11) investigated in this study Cells were cultivated as described in the supplemental data The PET tracer was added to the cells (100–150 kBq/well 3 wells per tracer) and incubated at 37°C for 2 and 4 h 2-(phosphonomethyl)pentanedioic acid (100 μm/well) was used for blocking studies and measured in a γ-counter (Wizard 1470; PerkinElmer) and percentage uptake per 105 cells was calculated Uptake of 18F-DCFPyL was always measured in parallel Cellular uptake values were compared using 2-way ANOVA followed by the Sidak multiple-comparison test (P < 0.05) 2 female; 250–530 g) were used for this study Rats were housed in groups of 2–4 animals under controlled conditions (22°C ± 1°C and 55% ± 5% relative humidity) and an inversed 12-h light/dark schedule (lights on 8:30 pm–8:30 am) Experiments were performed in accordance with European Union directive 2010/63/EU for animal experiments and were approved by regional authorities (Ministry for Environment The 120-min measurement was divided into different time frames (2 × 60 min or 4 × 30 min; for time–activity curves: 2 × 1 min Postprocessing and image analysis were performed with Vinci version 4.72 (Max Planck Institute for Metabolism Research) Frames were Gauss-filtered (1 mm in full width at half maximum [FWHM]) and intensity-normalized to injected dose Tracer tissue accumulation was measured for the 60- to 120-min frame and compared among tracers using 1-way ANOVA followed by Dunnett multiple-comparisons testing TBR describes the delineation of PSMA-positive ganglia against PSMA-negative background Two elliptic volumes of interest were used: The first volume of interest (150 voxels) was placed over the superior cervical ganglion (SCG) and the second (1,600 voxels) over the neck region dorsal from the spinal cord Volume of interest mean values were extracted and the SCG/background ratio was calculated TBR was first determined for candidate probes (18F-JK-PSMA-7-11 and -13) and compared with 18F-DCFPyL in the same animal for the time frame 60–120 min 18F-JK-PSMA-7 (56–63 MBq); its regioisomer 18F-JK-PSMA-8 (47–70 MBq); 18F-DCFPyL (45–71 MBq); 18F-PSMA-1007 (17–59 MBq); and 68Ga-PSMA-11 (13–51 MBq) were evaluated in 3 animals each 18F-JK-PSMA-9-11 and -13 were not further evaluated The image intensity of a PSMA-positive ganglion decreases gradually to background level forming a slope that reflects the edge contrast or acutance An 8-mm profile (1-pixel width) was placed over the middle of the SCG (diameter The slope of the profile plot was determined by dividing the maximum height of the SCG profile (peak minus background) by its FWHM The time frame used for this analysis was 60–120 min after injection Image quality parameters were compared among tracers using 1-way ANOVA followed by Dunnett multiple-comparisons testing TBRs were compared using 2-way ANOVA with the factors “tracer” and “frame,” followed by Tukey multiple-comparisons testing The time frame analyzed was 60–120 min after injection A first-in-human study with 18F-JK-PSMA-7 was performed on a patient within the clinical workup The patient had given his written informed consent for PET imaging and the scientific evaluation of his data All procedures were performed in accordance with the Institutional Review Board and the regulations of the responsible local authorities (Bezirksregierung Köln) 18F-fluoride was eluted from the anion-exchange cartridge with a solution of 28 in EtOH and the resulting solution was heated at 150°C for 20 min which was purified by solid-phase extraction and deprotected using H3PO4 or HCl in aqueous MeCN at 45°C for 5 min 18F-JK-PSMA-10 was isolated by high-performance liquid chromatography in 3%–5% radiochemical yield All tested PET tracers showed a significantly increased uptake in LNCaP cells after 4 h compared with 2 h (F1,34 = 8081; P < 0.0001 for factor “time”; post hoc P < 0.05) tracer uptake in PSMA-negative PC-3 cells was low (Supplemental Fig The PSMA specificity of tracer uptake in LNCaP C4-2 cells was confirmed by the inhibition with 2-(phosphonomethyl)pentanedioic acid Comparison between uptake in LNCaP C4-2 cells of 18F-4–11 in relation to that of 18F-DCFPyL is shown in Figure 3 Only 18F-JK-PSMA-7 exhibited a significantly higher cellular uptake than 18F-DCFPyL after 2 h (F7,38 = 1,136; P < 0.0001 for factor “tracer”; post hoc P < 0.05) uptake in LNCaP C4-2 cells after 2 h was significantly lower than that of 18F-DCFPyL (Supplemental Table 2) cellular uptake of 18F-JK-PSMA-7 in LNCaP C4-2 cells was also significantly higher whereas uptake of 18F-JK-PSMA-9 and -11 was comparable to that of 18F-DCFPyL All other tracers showed a significantly lower uptake after 4 h Because of the low PSMA-specific cellular uptake 18F-JK-PSMA-12 and -14 were excluded from further studies Tracer uptake in LNCaP C4-2 cells in relation to 18F-DCFPyL 18F-DCFPyL uptake after 2 h was normalized to 100% Only 18F-JK-PSMA-7 shows higher uptake than 18F-DCFPyL *Significantly different from 18F-DCFPyL at same time point F7,38 = 1,136; P < 0.0001 for factor “tracer,” post hoc P < 0.05 #Significantly higher than 2-h uptake of same tracer F1,38 = 6,981; P < 0.0001 for factor “time,” post hoc P < 0.05 18F-PSMA-1007 demonstrated the highest SCG accumulation (94.8 ± 19.6 SUVBW) because of the high background radioactivity of 15.86 ± 1.68 SUVBW the TBR for this tracer was not higher than the TBR for 18F-DCFPyL or 18F-JK-PSMA-7 and 18F-JK-PSMA-13 (4.3) were determined once in the same animal (Supplemental Fig Because of insufficiently high TBR (<4.5) (A) Sagittal section of PSMA image with SCG and background (Bg) volumes of interest (B) Graph showing that TBR (SCG/Bg) 60–120 min after injection did not significantly differ among groups (F4,10 = 2.95 *TBE significantly higher for 18F-JK-PSMA-7 than for 68Ga-PSMA-11 (F4,40 = 5.97 for factor “tracer,” post hoc P < 0.05) #TBR significantly higher for 18F-JK-PSMA-7 than for 18F-JK-PSMA-8 or 68Ga-PSMA-11 (P < 0.05) TBR of 18F-JK-PSMA-7 and 18F-PSMA-1007 increased significantly over time (F3,30 = 9.12 frame 4 was significantly different from frames 1 and 2 (P < 0.05) frame 4 was significantly different from frame 1 (P < 0.05) Comparison of Quality of PET Images Obtained with Different Tracers (60–120 Minutes After Injection Tracer Uptake (SUVBW) in Different Tissues 60–120 Minutes After Injection (n = 3 Each) Acutance (measured for SCG) using different PSMA tracers (A) Profile plot of 1-pixel profile (Pr in inset) through SCG center Peak against adjacent background (max) and FWHM were measured (B) Ratio max/FWHM roughly represents slope of profile plot and reflects acutance *18F-JK-PSMA-7 and 18F-PSMA-1007 show significantly higher acutance than 18F-DCFPyL Resolution of images acquired with different tracers (A) Profile plot of 1-pixel profile (Pr in inset) through apical pair of DRG Peak against adjacent background (max) and FWHM were measured for each ganglion (B) Formula R = 2(P2 − P1)/1.7(FWHM1 + FWHM2) yields image resolution *Image resolution was significantly higher for 18F-JK-PSMA-7 than for 18F-JK-PSMA-8 (F4,10 = 3.80 A first-in-human study was conducted with 18F-JK-PSMA-7 (Fig. 7) A 64-y-old patient with an elevated prostate-specific antigen level (130 ng/mL) was referred for PSMA PET/CT before further treatment A 18F-JK-PSMA-7 PET scan demonstrated tracer accumulation in the prostate 18F-JK-PSMA-7 scan in patient with relapsed PCa This 64-y-old patient had serum prostate-specific antigen level of 130 ng/mL Scan was started 233 min after injection of 384 MBq of 18F-JK-PSMA-7 (Left) Maximum-intensity projection of PET image (Right) PET/CT images at transverse levels indicated by blue lines 18F-DCFPyL, 18F-JK-PSMA-7–9, and 18F-JK-PSMA-11–13 were prepared using a 2-step procedure outlined in Figure 2 This modular approach enabled the application of the same building blocks for the synthesis of different radiotracers 18F-labeled active esters 18F-18–23 were obtained in radiochemical yields of up to 85% within 8–20 min using only 18F-fluoride and the corresponding labeling precursor without any evaporation steps The acylation step worked well only in anhydrous EtOH If the reaction was performed in aprotic or aqueous medium much lower radiochemical conversions (0%–15%) were observed The final purification by solid-phase extraction or high-performance liquid chromatography afforded tracers in good radiochemical yields (12%–25% non–decay-corrected) and excellent radiochemical purity (>98%) The simplicity of the preparation procedure enabled a straightforward transfer to synthesis modules Because of the insufficient stability of 18F-20 18F-JK-PSMA-13 was prepared from the corresponding protected precursor The electron-poor nature of the pyridazine ring allowed—for the first time to our knowledge—high-yielding SNAr radiofluorination in pure primary alcohols such as EtOH in more than 90% radiochemical conversions it also caused substantial decomposition during the deprotection step Next, we started the biologic evaluation of the novel radiotracers. Their PSMA-specific cellular uptake was compared with that of 18F-DCFPyL. As the predictive power of in vitro stability assays is limited (25) the metabolic stability of the candidates was determined in healthy rats High stability toward in vivo defluorination is especially important for PCa imaging 18F-fluoride avidly accumulates not only in PCa bone lesions but also in healthy bones This could lead to incorrect diagnosis and wrong therapy PSMA-specific cellular accumulation of 18F-JK-PSMA-9 18F-JK-PSMA-7 revealed significantly higher accumulation rates All 3 ligands were largely inert toward in vivo defluorination and were the closest structural analog of 18F-JK-PSMA-7 For the in vivo evaluation we used the rat peripheral ganglia as a model for small focal PSMA-positive lesions making use of their high PSMA expression and small size (2.5–3.5 mm) We determined the TBR of the above-mentioned candidates in the SCG of rats Only 18F-JK-PSMA-7 had a TBR higher than that of 18F-DCFPyL the small structural difference between JK-PSMA-7 and -8 (methoxy substituent in either 4- or 2-position of the pyridine ring) resulted in different biodistribution introduction of the 4-ThiaLys (18F-JK-PSMA-10) instead of the Lys residue (18F-DCFPyL) resulted in a lower PSMA-specific cellular uptake in vitro and a low TBR in vivo High blood protein binding should delay excretion of the tracer resulting in lower accumulation in kidneys and bladder This could be advantageous for detecting PCa metastases adjacent to the urethra and bladder could mask enrichment of the tracer in smaller lesions Although liver uptake of 18F-JK-PSMA-7 was higher than that of 18F-DCFPyL possibly because of the presence of the lipophilic methoxy group liver uptake of the regioisomer 18F-JK-PSMA-8 was significantly lower We assumed that this apparent discrepancy could be explained by defluorination of 18F-PSMA-8 in the liver as indicated by radioactivity accumulation in bones the time–activity curves of 18F-JK-PSMA-7 and 18F-PSMA-1007 decreased more slowly finally reaching a plateau above blood radioactivity This finding indicates active tracer–target binding and trapping (e.g. For 18F-PSMA-1007 and (to a lesser extent) 68Ga-PSMA-11 a significantly longer retention of radioactivity in blood led to increased background activity such as resolution and acutance (edge contrast) have so far not been used for the qualitative assessment of PET images High acutance increases the subjective perception of sharpness and allows improved measurements of lesion size Acutance was significantly higher for 18F-JK-PSMA-7 and 18F-PSMA-1007 than for 18F-DCFPyL Resolution is the ability to delineate 2 small target tissues close to each other 18F-JK-PSMA-7 exhibited the highest resolution the resolution of 18F-JK-PSMA-7 scans was significantly higher than that of 18F-JK-PSMA-8 scans The novel modular production protocol enabled the fast and high-yielding preparation of structurally different PSMA ligands Application of peripheral ganglia of healthy rats as models of small PSMA-positive lesions allowed fast and cost-effective preclinical screening of PSMA-specific PET ligands In the direct comparison with the already established PET tracers 68Ga-PSMA-11 in contrast to the regioisomeric 18F-JK-PSMA-8 demonstrated favorable properties with respect to image quality and sensitivity to detect small PSMA-positive tissues careful preclinical and clinical evaluations of 18F-JK-PSMA-7 are under way This study was funded by the LeitmarktAgentur.NRW and the European Regional Development Fund (LS-1-2-023c/EFRE-0800973 and LS-1-2-023b/EFRE-0800992) 18F-JK-PSMA-7 is the subject of a patent application by Boris Zlatopolskiy for providing the LNCaP C4-2 cells; Marco Müller for providing the PSMA-1007 and its precursor; and Austin Craig for proofreading the manuscript ↵* Contributed equally to this work Construction begins on project that will unite Muslims Muslims, Jews and Christians are to be united for worship under one roof in Berlin in a groundbreaking project called ‘House of One’ The cornerstone of the multi-denominational temple was laid in the German capital on Thursday with supporters saying they hoped it would forge greater understanding between the three religions A mosque, a synagogue and a church will be combined on the site on Leipziger Strasse in the area where Berlin has its historical origins and on the former foundations of a 13th-century church which was badly damaged during second world war bombing and pulled down during communism the president of the Bundestag and a former economics minister called it a “location of tolerance and openness” which he said had the “theological aspiration to be open to other spiritual perspectives with equal respect” He stressed the importance of the project to promote dialogue between the religions and to fight fanaticism and violence which is to begin in earnest in the autumn and is expected to take four years Rabbi Andreas Nachama and Father Gregor Hohberg all of whom began discussing their dream for a joint establishment a decade ago The weekly Die Zeit has referred to the temple as Germany’s “most spectacular ecclesiastical construction project” who previously worked as a chaplain for US troops stationed in Berlin told the paper the project had emerged from years of dialogue between the three men “It was Father Gregor Hohberg’s brilliant idea to create a spiritual space on the spot where the oldest church in Berlin stood for 750 years Christians and Muslims together with other believers and non-believers It should become a house of mutual respect,” he said Sanci told German media he was pleased that Muslims in the city would finally find a place to worship in the city centre and not tucked away in less well-known locations as the majority of Germany’s estimated 800 mosques are The government has given €20m towards the €47m project while €10mis being provided by the Berlin state government and the remaining sum is expected to be collected in donations over the next four years The Berlin architectural bureau Kuehn Malvezzi is behind the construction competing with gleaming high-rises on Leipziger Platz and nearby Potsdamer Platz many of which have been erected over the past 30 years since the fall of the Berlin Wall the president of the Central Council of Jews in Germany said he welcomed the fact the project would encourage inter-religious dialogue “Here religions can talk with each other instead of about each other,” he said the chair of the Council of the Evangelical Church in Germany told German media the building sent an important signal “at a time in which antisemitism and Islamophobia are increasing,” he said Suite C1-310 Danforth AveToronto ON M4K 1N6Canada The House of One is intended to show that peace is possible among Abrahamic traditions but some Berliners think it's an overwrought symbol (RNS) — Three religions The concept could be profoundly simple or particularly complex For Berlin’s “House of One,” it’s turning out to be a bit of both Dubbed “the world’s first churmosqagogue” by one Reddit user the House of One — “the world’s first hybrid church-mosque-synagogue” — will break ground in Berlin on May 27 it will have been a project 12 years in the making at an expected cost of at least 47.2 million euro (C$72.5) Its designers and leaders hope it will be used by Jewish, Christian and Muslim members as a place to pray host a dialogue among their respective religions and with society at large But while the House of One is intended to show that peace is possible among — and through — the world’s so-called “Abrahamic traditions,” some Berliners regard it as an overwrought symbol that has little practical purpose in the heart of one of the world’s most cosmopolitan cities The idea for the House of One came to Protestant pastor Gregor Hohberg after he discovered the ruins of Berlin’s first church had been destroyed and reconstructed repeatedly before being torn down during the Cold War Hohberg wanted to honour the history of the place with a new building “It had to be something that spoke to Berlin Hohberg sought out Jewish and Muslim partners a former rabbi for the American military synagogue in Berlin’s southwest The three began the slow process of getting to know one another and raising funds for the massive building project “At first we were conversation partners,” said Sanci “The focus was on togetherness, spending time together, learning together and cooperating on a major construction project,” he added. Hohberg chimed in, “and by cooperating on a major construction project you learn a lot about people through that!” The three have grown to become more than just friends but “Seelenverwandte” — or “soul relatives,” who plan to seal their friendship at a groundbreaking ceremony at Petriplatz “On our way to peace in heaven, we have the chance to create that here on earth,” said Nachama, “but that’s not to be taken for granted. You have to work at it and build a place for peace on earth.” The House of One’s architectural design has received lots of attention over the last decade But the emphasis is on the spacious “Begegnungsraum,” or meeting place that connects them where people of all backgrounds will be invited to build relationships of peace like the one Hohberg shares with Nachama and Sanci “the House of One becomes more than a house of prayer The House of One is not the first attempt at housing the Abrahamic faiths together and the Abrahamic Family House in Abu Dhabi and elsewhere have been compared to the House of One “The House of One is just a ‘test-case’ for how we can actually build peace.” the metropolitan bishop of the Evangelical Baptist Church of the Republic of Georgia drew inspiration from the House of One for his own “Peace Project,” which locals also refer to as the House of One Established as the First Baptist Church of Tbilisi in 1867, the Peace Cathedral is the mother church of the Evangelical Baptist Church of Georgia. “In the course of its history, Peace Cathedral has repeatedly taken bold stands in support of oppressed minorities,” said Songulashvili “even as the church has suffered periodic harassment from religious extremists.” Painfully aware of religion’s role in violent conflicts such as the recent nearby Nagorno-Karabakh war Songulashvili’s congregation took the bold step of constructing a mosque and a synagogue attached to its church building “creating a spiritual home for Abrahamic faiths including both Sunni and Shia Muslims,” he said Bishop Ilia Osefashvili said that without the House of One in Berlin’s support “a project like House of One helps us to build bridges of peace and friendship with other religions alienation and hostility are difficult to overcome.” The House of One has also established a formal partnership with “the House of Peace and Religions” in Bangui, the capital of the Central African Republic, a majority-Christian country where faith has fueled conflict in recent years Berlin’s House of One has worked with the country’s cardinal Dieudonné Nzapalainga; the former president of its Islamic Council Imam Oumar Kobine Layama; and president of its Evangelical Alliance the House of One has faced criticism at home While the House of One’s intentions are in the right place Some have complained that the exorbitant cost could have been better spent pastor and consultant on migration and integration for the Protestant Church in Germany (EKD) expressed concerns that the House of One will showcase its founders’ hopes more than bring faiths together in the city.  “We need something that speaks to Berlin on the inside and not just on the outside,” Apel said but we need a place that is more than a meeting point for tourists who pastored in Berlin’s diverse Neukölln and Kreuzberg communities said interreligious work is difficult in the city especially given Germany’s “disastrous national history.” can be a place where “Germans can develop a better intercultural competence,” she said but added that “the House of One lacks grassroots support.”  Apel and others fear that Sanci’s association with Fethullah Gülen the Turkish imam who founded the Hizmet Movement Hizmet describes itself as a “faith-inspired civil society” but has run afoul of the ruling AK Party in Turkey for its supposed political aspirations It is a lightning rod in the broader German Muslim community particularly for its large Turkish minority “The Gülen movement is not representative of Muslims in Berlin,” said Apel “and could never be because of the political situation.” You can’t have a ‘House of One’ without involving people of other religious groups.” the managing director for the Berlin Forum of Religions agreed that the House of One missed an opportunity by not speaking to Berlin’s broader religious diversity “It’s a difficult task to bring different people together for dialogue,” he said “and a lot of religious people in Berlin aren’t really interested in the House of One.” They have a lot of work to do to reach beyond the three religions.” Bäumer has cooperated with the House of One on different multifaith initiatives and admires the leaders’ meaningful multifaith relationship They are good people and we often talk together “the important question will be whether they can open their relationship of peace to other persons of belief.” Hillhurst United now draws hundreds every week Banned for life from the Ontario legislature's public gallery for his protest Jeffrey Dale is an outspoken advocate for safe-consumption sites As much as we respect our friends who are Jewish and/or Muslims we are called to be separate from the world Just reading this article show the many flaws that comes when one tries to mix Christ with the world Regardless of the resistance to the undertaking I think it is wonderful that there is a start to understanding each other and becoming friends in this world we have have to accept and understand our diversity How does one reconcile 2 Corinthians 6:14-15 and John 15:18-25 1 Corinthians 6:1-3 are we not called to judge 2 Corinthians 10:5 and 1 Peter3:15 tells us to defend the faith A terminal cancer diagnosis put Catherine Wreford and Craig Ramsay's decades-long friendship to the test The pontiff hasn't changed church teaching on marriage in indicating support for same-sex civil unions he is reminding Catholics they should be concerned about justice for all But many are encouraged that local church communities can decide for themselves what to do next Stephen Milton says the number of crosses relates to Ontario’s daily death count "My Year of Living Spiritually" is most inspiring when it finds transcendence in community 13 Apr 2025 18:15:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Sport Boys won 4–0 over Comerciantes Unidos on Sun The current head to head record for the teams are Comerciantes Unidos 1 win(s) 13 Apr 2025 18:15:00 GMT?Sport Boys won 4–0 over Comerciantes Unidos on Sun 13 Apr 2025 18:15:00 GMT.InsightsHave scored 8 goals in their last 5 matches Comerciantes Unidos is playing home against Sport Boys at Estadio Municipal Germán Contreras Jara on Sun Thomas HardingLondonMarch 18 as illustrated by the recent violence at Jerusalem’s holiest site Or it can be a sign that flocks are dwindling But Berlin’s House of One intentionally puts a church This article appeared in the Europe section of the print edition under the headline “One roof Discover stories from this section and more in the list of contents George Simion will face Nicusor Dan, a mainstream candidate, in a run-off There are five luxuries it can no longer feasibly afford Friedrich Merz’s career is one of unforced errors and puzzling missteps. But he is serious about Europe Both Donald Trump and Ukraine’s diplomats will consider it a success Registered in England and Wales. No. 236383 | Registered office: The Adelphi, 1-11 John Adam Street, London, WC2N 6HT | VAT Reg No: GB 340 436 876 06 Apr 2025 19:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Sport Boys vs Los Chankas on Sun The current head to head record for the teams are Sport Boys 1 win(s) Have scored 7 goals in their last 5 matches 06 Apr 2025 19:00:00 GMT?Sport Boys vs Los Chankas on Sun 06 Apr 2025 19:00:00 GMT ended in a 1–1 tie.InsightsHave scored 5 goals in their last 5 matches Sport Boys is playing home against Los Chankas at Estadio Miguel Grau del Callao on Sun By submitting the above I agree to the privacy policy and terms of use of JTA.org But actually, this isn’t a joke, or a bar. It’s an extraordinary new building called the House of One also known as “the medieval birthplace of Berlin.” Berlin – as Rabbi Tovia Ben-Chorin says in House of One’s promotional video this city is ‘The City of Wounds’ and ‘The City of Miracles.’” The House of One will welcome people of multiple faiths and hopefully mark a new era in religious tolerance. The three religious leaders spearheading the project are Rabbi Tovia Ben-Chorin, Pastor Gregor Hohberg, and Imam Kadir Sanci. The design team (picked through a competition) is from the Kuehn Malvezzi architectural firm and they’ve already released some images of the proposed structure There will be one door for everyone to walk through each worshipper may climb the stairs and choose one of three prayer spaces to enter Even the construction phase is about collaboration. Everyone is encouraged to donate a brick for ten euros a pop The founders encourage everyone to get involved and even invite people to send in suggestions for their calendar of events Americans, relax: You’ll get one, too. NPR just reported that one of these is coming to Omaha, Nebraska, too: on the site of an old Jewish country club JTA has documented Jewish history in real-time for over a century Keep our journalism strong by joining us in supporting independent I accept the Privacy Policy. 22 Feb 2025 20:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Sport Boys won 2–1 over Ayacucho FC on Sat The current head to head record for the teams are Sport Boys 6 win(s) Have scored 6 goals in their last 5 matches 22 Feb 2025 20:00:00 GMT?Sport Boys won 2–1 over Ayacucho FC on Sat 22 Feb 2025 20:00:00 GMT.InsightsHave scored 3 goals in their last 5 matches Sport Boys is playing home against Ayacucho FC at Estadio Miguel Grau del Callao on Sat Local COPA AUF SIN G�NERO HISTORICAL SOCIETY guests at the “Tea” event are There is not an organization, a gaggle of friends or lovers of beauty and style in our ’hood that does not look forward to the Fashion Institute of Design and Merchandising (FIDM) Museum’s spectacular annual exhibition of “The Art of Motion Picture Costume Design.” The gala opening was held in February at the downtown campus for the 26th year There were 900 guests and designers treated to a first peek at the more than 125 costumes including work by all five of this year’s Academy Award nominees for costume design “It just gets better every year!” said a dapper-looking Nick Verreos The red carpet led into an enormous crystal tent decorated with chandeliers and laden with buffets of hearty fare and spirits Spotted among the throng and thrilled to be there were Ginger and John Barnard Academy Award nominated designers Mark Bridges and Luis Sequeira four-time Academy Award winner for Costume Design Colleen Atwood curators Kevin Jones and Christina Johnson and FIDM president Tonian Hohberg This amazing display will continue through Sat. CHILDREN’S CHAIN fundraising event included Hancock Park’s Court and Liz Young A “Night in Havana” actually took place in Beverly Hills, at Spago. A fundraiser for Children’s Hospital Los Angeles, organized by Children’s Chain Stalwart Children’s Chain supporter Carlotta Keely and husband Rusty brightened up the event (Carlotta with a Carmen Miranda headdress) The fund-raising pitch to help the hospital came from Amanda Wells Lovrien Many neighbors joined in a birthday send-off to the late Jerry Cohen who died just about two months before his 100th host Steve Cohen naturally served fabulous pizza from Village Pizzeria Family members attending included his brother HOLLYHOCK proprietor Suzanne Rheinstein and neighbor toasted the store’s 30 years in Los Angeles generated a big turnout for the first night of the store’s big closing sale Hollyhock was ensconced in the middle of our community on Larchmont Boulevard Its final location on La Cienega was the site of a party featuring many from the ’hood: Melanie Boettcher spoke with Olivia Penfold and mom Also there was Fremont Place denizen and “Larchmont Buzz” publisher MORE from Windsor Square were Cheryl Ziegler and Anne Ziegler Manson as were Cheryl Ziegler and her daughter Anne Manson plus Georgia and Lou Howe and Pamela Clyne and Janet Loveland Among those from Hancock Park were Carlotta Keely Patsy Lowry with her brother-in-law Hunt and his wife “Winter in Chicago,” has just been published and David Hamlin was signing copies of the new Emily Winter mystery “Winter Gets Hot,” upstairs at the Original Farmers Market Among the many attending were the Market’s Mark Panatier and his wife Gail LINCOLN’S BIRTHDAY gathering guests Kevin and Mary O’Connell history-minded and patriotic Los Angeles leaders have celebrated the life of President Abraham Lincoln around the time of his birthday At each of the annual black-tie dinners of the Lincoln Club distinguished and nationally known speakers have talked and the evening has ended with a solemn reading of the Gettysburg Address and The California Club’s main dining room was filled to capacity Among the locals gathered to hear Will was former ambassador Still of Windsor Square and there to celebrate the former president were Judith and Clifford Miller and this paper’s publisher From Hancock Park were Allan and Nicole Mutchnik and their next-door neighbors Mary Adams O’Connell and husband Kevin Sitting at the head table were Lincoln Club board of governors members Janet Clayton and Robin Kramer  Also serving on the board is former ambassador Robert Tuttle and retired Superior Court judge Carlton Seaver Leilani and Edwin Raquel opened the Grand Ballroom of their Fremont Place home for “Love, Scandal and … Tea” on a Sunday afternoon in February. The event was the brainchild of the Windsor Square-Hancock Park Historical Society and attracted a capacity crowd Hollywood expert Marc Wanamaker enchanted his audience with his vast knowledge of the stars their less than dignified moments and their real estate during the early years of the exploding local movie industry gloves and pearls and the gentlemen kept it classy There to nibble on cucumber sandwiches and salmon mousse were Shar and Robert Penfold Dia Schuldenfrei and daughter Angelique Campen WSHP Historical Society’s Vice President and event Chair Myrna Gintel with daughter Victoria Blum and sister Dale Robin Gross The sold-out tea event taught a serious lesson for our ’hood: Join The WSHP Historical Society’s programs sell out Category: People Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" co-founder of German start-up Pfeffermind Games A trade mission focused on software development and gaming brought Irish and German companies together over a three-day event to foster collaborations and partnerships Hosted by the German-Irish Chamber of Industry and Commerce in Dublin’s Guinness Enterprise Centre the German-Irish Digital Innovation Summit introduced us to companies such as indie games studio The Good Evil; Kunst-Stoff which aims to make foreign-exchange trading as simple as Tinder; and Semknox which provides a B2B ‘search-as-a-service’ for online shops “The idea behind the event really was to bring together the expertise in Ireland with the expertise from Germany and just to look at what kind of co-operations can come out of it,” said Aideen Keenan head of marketing for the German-Irish Chamber The visiting delegates hoped to find potential partners or customers through this trade mission and all seemed quite won over by Ireland’s reputation and tech pedigree Tarek Hohberg from Pfeffermind Games labelled Dublin the tech hub of Europe but Berlin as the region’s start-up hub while in Berlin you’ll find a lot of entrepreneurial know-how you’ll find a lot of tech know-how here and I think there are a lot of synergies to be discovered,” he said While the ambitions of entrepreneurs the world over are shared cultural attitudes can create differences which might just be the perfect complement to one another “I think German entrepreneurs always have a tendency to be a little bit too risk averse,” said Robert Bachmaier head of sales for 30-year-old software development company Bittner + Krull “Irish people have a lot more courage to engage into new opportunities These comments will be music to the ears of Startup Ireland a collective of public and private partners with a plan to make Ireland a global start-up hub by 2020 Startup Ireland’s first annual Startup Gathering will play host to more than 300 events across the country in October editorial@siliconrepublic.com The world’s first hybrid church-mosque-synagogue will open in Berlin in May which has been 12 years in the making at an expected cost of at least 47.2 million euro gather and host a dialogue among themselves and with society at large The idea for the “House of One” came to Protestant pastor Gregor Hohberg after he discovered the ruins of Berlin’s first church Hohberg sought out Jewish and Muslim partners – Rabbi Andreas Nachama a former rabbi for the American military synagogue in Berlin’s southwest; and Imam Kadir Sanci learning together and cooperating on a major construction project,” he added Hohberg added: “And by cooperating on a major construction project The House of One’s architectural design provides equal space for Jews But the emphasis is on the spacious “Begegnungsraum,” or meeting place that connects them where people of all backgrounds will be invited to build relationships of peace Subscribe to our newsletter and stay updated on the latest news and updates from around the Muslim world and you understand its importance in today’s climate then please support us for as little as £5 a month Subscribe to our newsletter and stay updated on the latest news and updates By providing us with your information you are consenting to the collection and use of your information in accordance with our Terms of Service and Privacy Policy