OneFootball's home page Search Settings Sign In Sign InJoinBVB overcome next obstacle on the road to Europe – Kehl: "On a really good path" | OneFootballBorussia Dortmund After 16 points and 19 goals from the last six games, hope of a happy ending has returned to BVB who at one point had slipped to 11th place I think we've increased the pressure on the other teams,’ said Sebastian Kehl commenting on the significantly improved position ahead of the final two games in Leverkusen and at home against Kiel "We're on a really good path to achieving what the team are capable of I see great desire and a great willingness to run," said the sporting director The 4-0 (1-0) win over VfL Wolfsburg saw Borussia climb to fourth place thanks to braces from Serhou Guirassy (3/59) and Karim Adeyemi (69/73) SC Freiburg could move past them again with a point in their home game against Bayer Leverkusen on Sunday (17:30 CEST) But Saturday's success at SIGNAL IDUNA PARK which was played in front of a sell-out crowd of 81,365 bolstered Kehl's confidence: "If we win both games But that's where we want to be after Matchday 34." Only the brilliant interplay between two key players broke the deadlock Gross set up a goal for Guirassy - this time in spectacular style the midfielder left three Wolfsburg players standing on the byline and provided a perfect assist for the centre-forward This exact same move earned Gross a great deal of respect during his time in the Premier League with Brighton & Hove Albion "I've been doing that trick for a long time they used to call it the Cruyff turn," commented the midfielder with a mischievous smile Adeyemi also had a huge role to play in the win The forward was only on the pitch for 20 minutes but he was clearly keen to recommend himself for a place in the starting XI in future Less than 120 seconds after coming on as a substitute for Jamie Gittens (67) he increased the lead to 3-0 after a fine solo run and scored the next goal just four minutes later "Karim did a really impressive job," said coach Kovac The positive trend of the past few weeks and the encouraging personnel situation increases the anticipation for the pivotal match next Sunday (15:30 CEST) away to second-placed Leverkusen coach Kovac sees no reason for complacency: "The team are now at a really good level That's why we'll continue to point out what we need to do." Related NewsReport: Guirassy committed to Dortmund despite €70m release clause BVB wants Soumaïla Coulibaly back for the Club World Cup Nico Schlotterbeck reinforces his commitment to BVB Daniel Svensson nominated for April "Rookie of the Month" Manchester United will not sell Bruno Fernandes to Al-Hilal for any price The three players Xabi Alonso has requested Real Madrid to sign – report Inter Milan vs Barcelona – Predicted lineup and team news Consistent reports have indicated that Borussia Dortmund are considering offloading Julian Brandt this summer ahead of Dortmund’s 4-0 win over Wolfsburg on Saturday sporting director Sebastian Kehl played down the speculation saying the 29-year-old is likely to remain at the club next season “The likelihood is high - he has a contract But we’re not that far along yet; we haven’t talked about it,” Kehl told Sky Germany when asked about Brandt’s future Brandt has recently reminded Dortmund of his value scoring in last week’s 3-2 win over Hoffenheim and registering two assists in the dominant victory against Wolfsburg The attacking midfielder joined Dortmund from Bayer Leverkusen in 2019 for a fee of €25 million Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application April 14 at The Center at Lincoln skilled nursing facility Known to all as "Larry," he was a son Larry will be remembered as a great "mushball" of a man with an immensely positive attitude and a big heart that relished giving tight hugs He was a technology enthusiast and loved dogs rarely living without at least one at home He avidly pursued interests in photography and in smoking meats A graduate of Smoky Hill High School in 1981 and DeVry Institute of Technology in Phoenix AZ in 1984 with a diploma in Industrial Electronics & Technology Larry's primary career was spent as a lead technician in the burglar/fire alarm and fire suppression systems industry Larry fulfilled his youthful dream by working as a lift operator and ski school instructor at Keystone Ski Resort Many of Larry's fondest memories were from his years living in Dillon CO where he was hired by Apex Security for his first job in alarm systems While living in Summit County he served as a volunteer fire fighter often driving the the firetruck during 4th of July parades Larry and Joan built a beloved family home on CO Highway 9 at over 11,000 ft close to Hoosier Pass where they welcomed their son James into the world in 2003 son and the Beck family to international destinations including Italy and the Virgin Islands.  and had a special place in his heart for the many hours spent at his family home with his father It was during those fruitful hours of working in the garden fixing the sprinklers and maintaining the stalwart Wheel Horse tractor along side his "best friend" and dad where Larry developed his dedication to family and caring that ran throughout his life A celebration of Larry's life will be held at the family home on Saturday Anyone so moved would be encouraged to make a donation in Larry's name to Catholic Charities of Denver or the local animal shelter of your choice This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page She was the second youngest of eight siblings; Ernest Weller Because of the terrible times of World War II those in her family that were left in England and did not serve in the military were forced to flee to the United States but those in her family did not think twice to become proud American citizens Janet graduated from Hicksville High School at the age of 15 she started her training to become a registered nurse She worked numerous jobs; she was a nurse at Eastern Long Island Hospital wore badge number 23 as a Southold Town Police Officer and was the truant officer for Southold School District She was also a devoted member of Southold and South Carolina Methodist church where she was seen every Sunday singing her praises to the Lord and remained deeply in love and devoted to him till his passing on May 4 on their 58th anniversary and his 83rd birthday Janet is survived by her siblings Robert Weller Audrey Loukides and Eric Weller; her sister-in-law Lena Slodki; and her cousin Barbara Davids She is survived by her children Robert Kehl (Joanne) Janet is also survived by her grandchildren Robert Kehl Richard Pisacano and Stephenie Pisacano-Shetell She is also survived by her great-grandchildren Luca Shetell A celebration of life will be held at The Vine at North Fork Southold United Methodist Church on Saturday She will be buried at a later date at the Calverton National Cemetery in Wading River the family asks that donations be made to in memory of Janet M Kehl to either Calverton National Cemetery to help maintain the grounds where Janet and Andrew will be buried together or to The Vine at North Fork Southold United Methodist Church (631-734-6033) DeFriest-Grattan Funeral Home in Southold is serving the family who has turned around his tennis game with.. Leon Maurice Creighton of Greenport Village died Monday With the birth of river otter pups at the Long Island Aquarium and possible sightings of otters at Marion.. Dorothy Ellen Kehl age 85 of Beloit died Tuesday October 22 1939 to Royal and Lucille (Neyhard) Canfield in Shopiere Dorothy worked as a die cast operator for 25 years until her retirement on October 29 She was an active member of Grace Evangelical Free Church Dorothy loved her family and cherished her time with her grandchildren and great grandchildren Dorothy will be remembered for devoting her life to the Lord thirty seven great grandchildren and her brother Rev Special thanks to Lisa Leach and the staff at Beloit Memorial Hospital Dorothy’s Funeral Service will be at 12 Noon on Saturday October 26 Friends will be received on Saturday in the Funeral Home from 10:00 a.m Fond memories and expressions of sympathy may be shared on our website Jernaro Gilford had no idea at the time but when he picked off Utah’s Lance Rice late in the fourth quarter in 2001 he did much more than seal BYU’s come-from-behind victory Gilford made an indelible impression on Bryan Kehl “I was a senior in high school sitting in the student-recruiting section That play was iconic,” Kehl told the “Y’s Guys” podcast this week He was such an incredible player and a great teammate Gilford is still making plays in the Cougars secondary — as the cornerbacks coach and newly promoted defensive passing game coordinator “He has maximized the output of the guys he’s had,” he said “The way we have covered on the outside and at the back end is unprecedented I would argue that we have never been so complete in our secondary tackling and (being) assignment sound and that is why they were so good last year.” BYU finished its 11-2 season tied with Texas for the most interceptions (22) and ranked No 1 in total defense and scoring defense in the Big 12 I was hoping for six wins and then they went through the roof “The best programs compete every single year What can I do to get better?” The former linebacker said about his approach to spring drills 21 tackles-for-loss and three interceptions at BYU (2002 Watching the Giants beat the Patriots on Feb 2012 in Super Bowl XLVI was a painful sight for Kehl to see New York’s 2008 fourth-round draft pick was released in 2011 and quickly signed by the lowly Rams “I still remember sitting at my parent’s house all by myself watching that game anger and resentment (with) all my buddies celebrating on the field,” Kehl said Adding salt to his emotional wound was the fact that it wasn’t the first time the Giants won the Big Game without him “I missed (the Super Bowl) twice because (New York) won it the year before I got there and they won it the year after I left,” he said Kehl played 72 games over six seasons in the NFL (2008-13) Among his 95 solo tackles was a hit he will never forget Minnesota’s Adrian Peterson took the handoff and the Giants rookie stuck him in the backfield for a loss “He got up afterward and tapped me on the helmet and genuinely said “It was one of those moments that was like He’s such a superstar and that interaction was cool.” Peterson retired after 15 seasons and remains No 5 among the NFL’s all-time leading rushers with 14,918 yards He would have had a few more had Kehl not dropped him in the backfield in 2008 Dave McCann is a sportswriter and columnist for the Deseret News and is a play-by-play announcer and show host for BYUtv/ESPN+. He co-hosts “Y’s Guys” at ysguys.com and is the author of the children’s book “C is for Cougar,” available at deseretbook Support us She was the second youngest of eight siblings her family fled to the United States when she was 13 Janet graduated from Hicksville High School at 15 and began her training to become a registered nurse at 16 She worked as a registered nurse at Eastern Long Island Hospital and was the truant officer for the Southold School District She was a devoted member of the Southold and South Carolina Methodist churches and they remained deeply in love until his passing on May 4 by her children: Robert (Joanne) of Southold She is also survived by eight grandchildren and 10 great-grandchildren A service will be held at The Vine at North Fork Southold United Methodist Church in Southold as “A Celebration of Life” on Nov She will be buried at a later date at Calverton National Cemetery in Wading River donations may be made in memory of Janet M Kehl to Calverton National Cemetery or The Vine at North Fork Southold United Methodist Church Get fresh local news straight to your inbox every day Borussia Dortmund have extended the contract of Sebastian Kehl has been in the role since 2022 but was out of contract this summer The uncertainty around his future had become an increasing distraction for the club It’s been a complicated political period for Dortmund Long-term CEO Hans-Joachim Watzke will leave in the summer of 2025 inherited part of Watzke’s responsibilities within a newly-created sporting managing director role and his future has been in doubt ever since The return of former chief scout Sven Mislintat — with whom Kehl has a strained relationship — as technical director In an interview with Sky Deutschland in 2024 he admitted to being a “little disappointed” at not receiving the promotion but insisted that he was “happy” for Ricken and that the two “enjoyed a long-term the club have maintained that an extension for Kehl — who captained Borussia Dortmund as a player and made over 350 appearances – was a priority Ricken stressed that again at the club’s November AGM Nevertheless, without a formal agreement in place, speculation has continued around his future, and at a time when — on the field — Dortmund are enduring an awkward season under new coach Nuri Sahin, who was appointed in the summer. It meant that the transition on the pitch was being mirrored at the executive level above Sahin with Kehl now under contract for a further three years and the club’s recruiting direction assured Dortmund consider loan move for Rashford from Man United “I am extremely committed to Borussia Dortmund and am delighted to be able to continue working for this great club,” said Kehl upon the confirmation of his contract extension “I feel the trust our management has in me as sporting director and I would like to thank Lars in particular for the good and constructive discussions over the past few weeks.” Ricken added: “Sebastian and I have known and trusted each other for many years In recent weeks we have had intensive discussions about content structures and economic issues and have now brought these to a positive conclusion “Our primary goal is clear: We want to be continuously represented in the Champions League in the coming years and play the necessary role in the Bundesliga Sebastian has my full support on this path.” (Top photo: Sebastian Widmann/Getty Images) He was the proud big brother to his sister and an intensive engineering program at the University of Colorado After serving our country in the Army and the United States National Guard he had a fifty plus year career at the phone company One of his fondest career memories was his appointment to the National ESAC Committee He enjoyed years of collaboration and friendship Bob enjoyed coaching his sons’ baseball and soccer teams He had a knack of turning underdogs into winners on and off the field He also logged many hours volunteering at the National Sports Center for the Disabled in Winter Park and Meals on Wheels in Littleton In his retirement years he worked in West Yellowstone at the Museum He loved touring others in the Yellowstone Historic Yellow Bus and sharing his vast knowledge of Yellowstone National Park He was a man that will be remembered for a Coke and a smile Until we meet again… Rest in Peace Big Bob Services to be held at Fort Logan National Cemetery on November 1 Information will be provided at the service.  Enter your phone number above to have directions sent via text Kehl speaks on Brandt's uncertain futureBulinewsApril 28 2025 at 7:32 AM UTC·1 min readBorussia Dortmund sporting director Sebastian Kehl has commented on the future of Julian Brandt following recent speculation about a summer move who scored in Saturday’s 3-2 victory over Hoffenheim received strong backing from Kehl after his performance and he’s an incredibly important player for us," Kehl told Sky Germany Brandt has just one year left on his contract and unless both parties are keen on an extension Dortmund may look to cash in on him this summer and he will continue to be in the coming weeks,” said Kehl I know he’s 100 percent BVB - and players like him are what we need." Borussia Dortmund's sporting director Sebastian Kehl entered the mixed zone after today's victory over Borussia Mönchengladbach The 45-year-old praised the team for their hard work and determination to see out the result "We've now had two 'English weeks' in a row and still managed to produce a really good performance My compliments to the team for the way they put up a fight again today ran a lot more and had a lot more possession we could have made it a little easier for ourselves in the end We've had other phases this season where we might have ended up drawing games like this," Kehl added Daniel Svensson also faced the media after a memorable day in yellow and black - the 23-year-old Swede ended up netting Dortmund's third goal on the day and his first for the club  "I enjoy training and playing here every day And then in front of this crowd - it's just incredible and so emotional I actually scored my first goal at my previous club with a header," he explained.  age 92 of Crosby passed away on February 18 2025 at the Cuyuna Regional Medical Center in Crosby  He was born in Aitkin on September 21 1932 to Grant and Helen (Borg) Kehl.  Don was a retired employee of Potlatch in Brainerd with 34 years of service  Don was a member of the Immanuel Lutheran Church in Crosby and the Walter Scott Erickson American Legion Post #557 of Deerwood. Survivors include one son Shirley Davies of Aitkin; two grandchildren Anthony Kehl of Barnesville and Chassidy Kehl of Brainerd; and three great grandchildren. Preceding Don in death are his parents; his wife Robert and Willard Kehl. A Memorial service will be held at 2:00 p.m 2025 at the Immanuel Lutheran Church in Crosby with full military honors presented by the Walter Scott Erickson American Legion Post  Visitation will be one hour prior to the service at the church on Friday  Burial will be at the Bethlehem Lutheran Cemetery in Nordland Township Arrangements are with the Koop Funeral Home in Crosby The basic reason for this struggle is that Mislintat wants Kehl’s job and this has resulted in the pair not getting on When Mislintat returned to the club it was hoped that his way of working would help spark success at the club but it has not and the pair cannot work together and limit their interactions When it comes to transfer issues the pair have different views the arrivals of Waldemar Anton and Pascal Groß were Mislintat’s ideas while Yan Couto and Maximilian Beier were Sebastian Kehl’s ideas The only player the pair agreed on was the signing of Serhou Guirassy But it is not just Kehl that Mislintat did this with, the former Arsenal and Stuttgart director wanted Rayan Cherki, while Nuri Şahin did not and Mislintat also negotiated with Yakuba Minteh over a potential transfer without Kehl knowing before the winger moved to Brighton Kehl is said to be in a very weak position especially as he was not promoted to be Hans-Joachim Watzke’s replacement and Lars Ricken was handed the role instead Kehl has lost Slaven Stanic and Eduard Graf from the Dortmund staff who were pro-Kehl This has resulted in Kehl’s ideas usually being voted against Kehl previously tried to extend the contract of Mats Hummels as well as sign Dean Huijsen for €15m from Juventus but the ideas were rejected and Anton came in instead The same thing happened 18 months ago when Kehl proposed the signing of Edson Alvarez GGFN | Jack Meenan  playGomez: Gio Reyna is 'rotting' at Borussia Dortmund (1:06)Herc Gomez explains why he thinks Gio Reyna should leave Borussia Dortmund in this transfer window adding that "he could become important for us" this season Reyna made 11 appearances for Dortmund in the first half of the season before being loaned to Nottingham Forest, where he saw little action and did not persuade the Premier League club to make the move permanent prompting rumours Dortmund might seek to transfer him There's nothing on the table and I haven't heard that the player wants to leave," Kehl told Bild who said he expects Reyna to stay this season under new head coach Nuri Sahin Reyna played in Saturday's Bundesliga opener, going in at the 81st minute in the team's 2-0 win over Eintracht Frankfurt Kehl said Reyna has a chance to grow into a role at Dortmund "He has to accept his role, free himself from it," Kehl said. "It was clear when we had the talks in the summer that Gio wanted to take on this role that there will be enough games in which we need him We know that he has incredible abilities." Gio Reyna played minutes in Dortmund's 2-0 win over Eintracht Frankfurt last weekend. Leon Kuegeler/Getty Images"He worked on himself, worked on his stability, worked on his charisma," Kehl said. "This clever turning between the lines and his goal threat -- he has developed that further Gio can still be very important for us this season." Dortmund play at Werder Bremen next Saturday before the international break. The U.S. will host Canada in Kansas City 7 and New Zealand in Cincinnati three days later in a pair of friendlies (Trent Nelson | The Salt Lake Tribune) Westminster University in Salt Lake City is seen in this photo from Saturday Sept A lawsuit filed against the school by a former soccer player was dismissed in December 2024 A high-profile lawsuit filed by a former soccer player against Westminster University last year has been tossed out — but the dismissal was not based on whether there was merit to her sexual harassment and hazing allegations a federal judge threw out Naomi Kehl’s case this week on a technicality: She no longer had an attorney representing her And 21 days after her representation withdrew Kehl also failed to respond to the court’s request asking about her intentions on moving forward meaning she can refile later if she does find an attorney The decision puts an end — at least for now — to the case that initially drew widespread attention against the small private university in Salt Lake City In her lawsuit, Kehl had alleged that when she was a freshman on the women’s soccer team in April 2021, she and other new players were forced to take part in an “initiation ritual,” where they had to answer sexual questions in front of male coach Tony LeBlanc She said it took place on a bus to an away game “How many sexual partners have you had?” and “What is your favorite sexual position?” were among the questions They would become increasingly explicit until the player answering had nothing left to say or broke down crying from embarrassment or anxiety from the game they called “the hot seat.” LeBlanc, who is also an assistant attorney general for Utah piped in with his own follow-up questions and laughed at the players’ answers Kehl said some of the players didn’t want to participate but felt they must to avoid repercussions including being benched for games if they didn’t she called the experience sexual harassment and said the coach had an obligation to not let the ritual happen — and not to join in went to complain about it to administrators LeBlanc then allegedly retaliated against her and benched her for four games Kehl argued that it wasn’t appropriate for the coach to continue in his position and that he violated federal Title IX law on sexual harassment LeBlanc is a Westminster alumnus who played for the men’s soccer team, according to his biography on the school’s website. He has coached the college’s women’s soccer team the entire time it has existed and is still currently listed as head coach. He has worked in the Utah attorney general’s office since 2010; initially, when the lawsuit was filed, he was placed on leave while the office internally investigated the allegations. A spokesperson for the office said the investigation “did not substantiate any of the allegations,” and LeBlanc returned to work. Kehl’s lawsuit was originally filed by the Lento Law Group, with three attorneys there representing her. One stepped down in April, according to the court docket, and the other two followed later in the summer. A spokesperson for the group did not respond to a request for comment from The Salt Lake Tribune. Calls to Kehl and her father this week also were not answered. Westminster had pushed for the case to be dropped based on Kehl’s lack of representation. The school also filed a motion to dismiss the case, saying her claims that the school did not take action were unfounded. When the university received the report from Kehl’s father, Westminster said it investigated the allegations, suspended the coach for two games and required all athletes on the soccer team to complete Title IX training. Title IX law, the school said in its filing, “does not require ‘flawless investigations or perfect solutions.’” It continued that Kehl “cannot succeed in her claim that Westminster [University] remained deliberately indifferent to her. She may not like the outcome reached, but her complaint fails to assert deliberate indifference.” The school also argued that the alleged “hot seat” game happened once, was not “pervasive” and did not deny Kehl of educational opportunities. Westminster also claimed the decision to bench Kehl was not made by LeBlanc — and instead by another coach — and was based on another player performing better as goalkeeper. On Tuesday, a spokesperson for the school issued a brief statement: “Westminster University is pleased the legal process resulted in a dismissal of the claim.” For e-edition questions or comments, contact customer support 801-237-2900 or email subscribe@sltrib.com sltrib.com © 1996-2025 The Salt Lake Tribune Metrics details the underlying neural processes of human olfaction are still poorly understood at the fundamental—that is Here we report recordings of single-neuron activity in the piriform cortex and medial temporal lobe in awake humans performing an odour rating and identification task We identified odour-modulated neurons within the piriform cortex neuronal firing accurately encodes odour identity repeated odour presentations reduce response firing rates demonstrating central repetition suppression and habituation Different medial temporal lobe regions have distinct roles in odour processing with amygdala neurons encoding subjective odour valence and hippocampal neurons predicting behavioural odour identification performance Whereas piriform neurons preferably encode chemical odour identity hippocampal activity reflects subjective odour perception we identify that piriform cortex neurons reliably encode odour-related images supporting a multimodal role of the human piriform cortex We also observe marked cross-modal coding of both odours and images especially in the amygdala and piriform cortex we identify neurons that respond to semantically coherent odour and image information demonstrating conceptual coding schemes in olfaction Our results bridge the long-standing gap between animal models and non-invasive human studies and advance our understanding of odour processing in the human brain by identifying neuronal odour-coding principles regional functional differences and cross-modal integration Odours activate olfactory sensory neurons (OSNs) which is connected to hippocampus (Hp) and PHC Innermost clinical electrodes projected to the MNI-ICBM152 template The post-implantation computed tomography (CT) scan co-registered onto the pre-implantation MRI scan schematic (top right) and scalpel-trimmed microwire (bottom right; scanning electron microscopy (SEM)) Respiratory depth (mean ± s.e.m.) aligned to odour delivery The odour rating and identification task: 15 odours (+1 odourless control) were presented 8 times in a pseudorandom order the participants rated (like or dislike) each odour the participants identified the correct odour (four options; four times per odour) showing ratings (left) and correct identification (right) The box plots show the median values (centre lines) and the whiskers span data within 1.5× the interquartile range Statistical analysis of odour identification was performed using two-sided Wilcoxon signed-rank tests versus chance (25%; dashed line); for all 15 odours The firing rate varied significantly with odour identity (left; one-way analysis of variance (ANOVA) Odour-modulated neurons per session and region (mean ± s.e.m.) EC and hippocampus host significant populations of odour-modulated neurons (PC P = 0.78; two-sided Wilcoxon signed-rank tests versus chance; the dashed line indicates 5%) EC and hippocampus increase their firing rate (FR) after odour stimulation versus the odourless controls (PC P = 0.63; all compared with control: n = 404 P < 10−10; two-sided Wilcoxon signed-rank tests) PSTHs (odour-modulated (red) versus other (grey) neurons; 50 ms bins) Odour-modulated neurons increase firing in all regions except in the PHC (two-sided Wilcoxon signed-rank tests comparing z-scored firing rates (0–2 s after odour onset) against zero; PC Diagrams were created using BioRender (a) and Noun Project (e) it remains unclear whether and how individual neurons respond to olfactory cues and encode odour identity We therefore investigated the individual contributions of central olfactory areas to odour processing and their link to human behaviour at the neuronal level We took advantage of the rare opportunity to record individual neuron activity in the human PC and MTL during an odour rating and identification task Such single-unit recordings offer unique insights that bridge the long-standing gap between animal electrophysiology and human imaging studies in olfactory research We identified odour-modulated neurons that effectively encode odour identity We further demonstrate a distinct role of the amygdala in emotional processing of odours and highlight hippocampal involvement in odour identification not only do our recordings reveal that PC neurons are able to encode the identity of odour-related images but they also demonstrate cross-modal integration of visual and olfactory information in both the PC and amygdala whereas no such increase was observed in the parahippocampal cortex (PHC) our findings firmly establish the existence of odour-modulated neurons both in the human PC and MTL Odour-identity decoding: neuronal spiking was used to train decoders to predict odour identity (here The odour-identity decoding accuracy per region Each red dot shows the decoding performance based on 200 randomly drawn neurons (1,000 subsampling runs) The decoding performance (mean ± s.e.m.) across subsampling runs is shown in black The grey dots indicate the decoding performance on label-permuted data The chance level (6.25%) is indicated by the dashed horizontal line Significance was calculated based on the percentile of mean decoding performance of the real data within the surrogate distribution (PC P = 0.16; label permutation test with n = 1,000 permutations) Odour-identity decoding (mean ± s.e.m.) as a function of the number of neurons included (100 subsampling runs) The horizontal bars below the dashed line (chance level) indicate neuron counts with significant odour-identity decoding (P < 0.05 right-sided Wilcoxon signed-rank tests against chance with Bonferroni correction for different neuron counts) Odour-identity decoding (mean ± s.e.m.) as a function of the decoding time window beginning at odour onset (200 randomly drawn neurons The horizontal bars below the dashed line (chance level) indicate the times of significant decoding performance (P < 0.05 right-sided Wilcoxon signed-rank test against chance with Bonferroni correction for 80 time windows; beginning of sustained significant decoding: PC The odour decoding performance (mean ± s.e.m. black) per recording session and region (coloured dots) Despite the limited and variable neuron counts per session odour identity could be decoded significantly above chance (6.25% 14 out of n = 17 sessions showed significant decoding compared to 1,000 odour-label-permuted data Diagrams were created using BioRender (a) and Noun Project (a) our analyses reveal differences in sparseness across central odour-processing areas in conjunction with central repetition suppression This correlation was observed in a significant number of sessions (6 out of n = 27 P = 0.002) and participants (4 out of n = 17 Linear regressions (black) with 95% confidence intervals (grey) Odour identification: the participants chose the odour label Neuronal odour-decoding accuracy and behavioural odour-identification performance across regions and sessions (coloured dots) The decoding accuracy in the hippocampus was positively correlated with behavioural odour-identification performance across sessions (Spearman correlation The difference in decoding accuracies based on chemical versus perceived (selected) odour identity PC neurons decoded chemical odour identity more reliably whereas hippocampal neurons predicted selected odour labels more accurately (PC 75.8% chemical versus 22.1% perceived more accurate P < 10−10; amygdala: 45.6% versus 49.7% P = 0.0024; two-sided Wilcoxon signed-rank tests across 1,000 subsampling runs) Diagrams were created using BioRender (a and f) and Noun Project (a and f) our findings reveal distinct roles of amygdala neurons in odour-valence coding and hippocampal neurons in odour identification The decoding performance for cross-modal decoding trained on images and evaluated on odours (d) and vice versa (e) (image to odour: PC An amygdala neuron that increases firing in response to banana odour a banana image and the written word ‘banana’ (right-sided Wilcoxon rank-sum tests comparing the pre-odour baseline firing rates (n = 128 2 s) with the firing rates after the onsets of odours (n = 8 A PC neuron that increases firing in response to the odour of liquorice and anise The same neuron exhibited the most pronounced response to liquorice among images and names (liquorice Pimage = 0.026; statistical analysis was performed as described in g) Diagrams were created using BioRender (a) and Noun Project (a this neuron also responded to a second odour an odour that is typically associated with and contained in liquorice candy These observations in the amygdala and PC suggest semantic representations of odours at early stages of olfactory processing our findings reveal encoding of odour-related visual information in human PC neurons as well as multimodal odour representations in the human amygdala and PC Despite the importance of human olfaction in health and disease our understanding of central odour coding relies primarily on animal models and human imaging studies Although highly informative at the macroscopic level functional human brain imaging lacks both the spatial and temporal resolution necessary to investigate the individual neuron and circuit coding logic underlying human olfactory processing We are therefore facing a considerable knowledge gap in human olfactory research Here we recorded from human single neurons in PC and MTL providing insights into olfactory processing Across both primary and secondary olfactory areas we identified neurons that responded to odours and altered their firing based on odour identity We observed suppressed response strength after repeated odour presentations at prolonged intervals beyond peripheral sensory adaptation Analysis of population sparseness revealed a more distributed code in PC compared to MTL regions neuronal activity in both the PC and MTL could accurately decode odour identity Our findings suggest that different MTL regions mediate distinct aspects of odour processing whereas hippocampal activity predicts odour identification performance we show that human PC neurons efficiently encode odour-related image identity Integrating data from both odour-related visual and olfactory stimuli we identified neurons with the ability to represent a specific stimulus concept (for example banana) in a cross-modal manner by responding to the scent The PC and amygdala in particular engage in cross-modal coding the labelled-line organization of chemotopic information established in the human olfactory bulb is disrupted along the bulb-to-PC signalling axis setting the stage for future studies to decipher the human olfactory code future studies should also systematically vary odour intensity to investigate the interplay of valence and intensity coding high-end olfactometers allowing for precise odour control will be essential Our results link odour representations of hippocampal neurons directly with behavioural odour-identification performance indicating that hippocampal degeneration may contribute to odour-identification deficits Impaired behavioural odour identification performance could be a direct result of local neurodegeneration or could instead result indirectly from degeneration of upstream circuits (for example Future research will have to explore causal contributions of odour-modulated neurons in odour identification chemosensory concept cells have not been identified to date We observed neurons that generalize their response to congruent visual and olfactory stimuli As demonstrated by cross-modal decoding analysis amygdala neurons in particular generalize their coding between the olfactory and visual domain our findings demonstrate concept-based neuronal coding in human olfaction Data were collected at the Department of Epileptology at the University of Bonn Medical Center All of the patients in our study had drug-resistant epilepsy and underwent invasive seizure monitoring with the goal of subsequent neurosurgical resection of the seizure-generating focus 27 sessions were recorded in 17 patients with epilepsy (12 female Microwire bundles were implanted bilaterally to record single-neuron activity in the MTL and also in the PC (17 sessions in 9 patients) All studies conformed with and were approved by the Medical Institutional Review Board of the University of Bonn Each patient provided informed written consent A total of 2,416 units was recorded (1,292 single units (SU)): 622 units (348 SU) in the amygdala 419 units (199 SU) in the PHC and 277 units (148 SU) in the PC Bilateral measurements of nasal airflow will allow future studies to precisely examine the interactions of neuronal activity and local oscillatory dynamics across the ipsilateral and contralateral hemispheres at a high temporal resolution Standardized pen-like odour stimuli lack millisecond precision and exact control of odour concentrations that can be achieved with high-end olfactometers this odour-delivery method proved to be both efficient and effective for presenting a wide range of odour stimuli in the clinical environment Neurons with a significant effect of image identity across all 128 trials (P < 0.05) were termed image-modulated neurons indicating that population decoding extrapolates well to larger populations of neurons The odour-decoding performance for each session was estimated based on all recorded neurons per region with a minimum of 2 neurons 8 cross-validation data splits and 1,000 resample runs a surrogate distribution was estimated by repeating the decoding analysis 1,000 times on odour-label-permuted data The percentile of the actual decoding performance within this surrogate distribution was used to estimate P values Decoding performances per participant were evaluated by averaging decoding performances across repeated sessions within anatomical target regions To test whether neural activity predicted chemical odour identity better than perceived odour identity (that is we used a decoding analysis during the odour-identification task (4 trials per odour) An equal number of neurons was randomly subsampled from recordings in which each odour was chosen at least twice 100 neurons were randomly subsampled 1,000 times and a decoder was trained using two cross-validation data splits and ten resample runs Decoders were trained based both on chemical odour identity and perceived odour identity (selected odour label) using the same neuronal populations The differences between the two decoding accuracies were used to assess which labels were predicted more accurately by neuronal firing Slopes were calculated for each region and compared with a constant response strength (that is a slope of 0) using a Wilcoxon signed-rank test All random effects comprised an individual intersect Likelihood ratio tests (MATLAB’s ‘compare’ function) confirmed that the full models that we used with both random slopes and intercepts outperformed models incorporating only random intercepts Poisson models were fitted based on the restricted maximum pseudo likelihood with a logarithmic link function two microwires from a new bundle were used wires were shortened to approximately 8 mm in length and mounted onto aluminium stubs using conductive carbon tape The samples were then sputter-coated with 15 nm of gold using a Quorum 150 R ES coating unit (Quorum Technologies) and imaged using the Everhart–Thornley secondary electron detector in a Zeiss Sigma 300 (Zeiss) Field Emission Gun SEM operated at 2 kV five images of two scalpel-trimmed microwires and four images of two untrimmed microwires were obtained Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Codes used to generate the main figures and reproduce the central results of this study are publicly available at GitHub (https://github.com/marcelkehl/HumanOdorRepresentations) Central mechanisms of odour object perception Poor human olfaction is a 19th-century myth A novel multigene family may encode odorant receptors: a molecular basis for odor recognition Wilson, D. A., Chapuis, J. & Sullivan, R. M. in Handbook of Olfaction and Gustation Ch. 10 (ed. Doty, R.) 209–224 (John Wiley & Sons, 2015); https://doi.org/10.1002/9781118971758.ch10 Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice Distinct representations of olfactory information in different cortical centres Mapping the microstructure and striae of the human olfactory tract with diffusion MRI Neurons and circuits for odor processing in the piriform cortex Representations of odor in the piriform cortex Odor quality coding and categorization in human posterior piriform cortex Dissociable codes of odor quality and odorant structure in human piriform cortex Activation and habituation in olfaction—an fMRI study Theta oscillations rapidly convey odor-specific content in human piriform cortex Spatial maps in piriform cortex during olfactory navigation Odor representations in olfactory cortex: “sparse” coding Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex Odor coding in piriform cortex: mechanistic insights into distributed coding Structure and flexibility in cortical representations of odour space Olfactory cortical neurons read out a relative time code in the olfactory bulb Odor-evoked activity in the mouse lateral entorhinal cortex Responses of amygdala single units to odors in the rat Neural correlates of olfactory processing in congenital blindness The human brain representation of odor identification Ultra-fine frequency tuning revealed in single neurons of human auditory cortex Representation of abstract semantic knowledge in populations of human single neurons in the medial temporal lobe The architecture of human memory: insights from human single-neuron recordings Neurons in the human basolateral amygdala and hippocampal formation do not respond to odors Ketamine-xylazine-induced slow (<1.5 Hz) oscillations in the rat piriform (olfactory) cortex are functionally correlated with respiration Sniffing and smelling: separate subsystems in the human olfactory cortex Nasal respiration entrains human limbic oscillations and modulates cognitive function Sparse coding and decorrelation in primary visual cortex during natural vision How many neurons can we see with current spike sorting algorithms The brain basis of positive and negative affect: evidence from a meta-analysis of the human neuroimaging literature Integrated neural representations of odor intensity and affective valence in human amygdala The relation between valence and arousal in subjective odor experience Invariant visual representation by single neurons in the human brain Explicit encoding of multimodal percepts by single neurons in the human brain Olfactory adaptation: recordings from the human olfactory epithelium Habituation of odor responses in the rat anterior piriform cortex Time course of odorant-induced activation in the human primary olfactory cortex Responses of human medial temporal lobe neurons are modulated by stimulus repetition Experience-dependent plasticity of odor representations in the telencephalon of zebrafish Recurrent circuitry dynamically shapes the activation of piriform cortex Non-invasive recording from the human olfactory bulb Amygdala response to both positively and negatively valenced stimuli Human amygdala represents the complete spectrum of subjective valence Dissociated neural representations of intensity and valence in human olfaction Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex Context-driven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex Preprocessing of emotional visual information in the human piriform cortex A rose by any other name: would it smell as sweet Olfactomotor activity during imagery mimics that during perception Verbal coding in olfactory versus nonolfactory cognition Olfactory imagery: is exactly what it smells like A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans Tay, A. S.-M. S., Caravan, B. & Mamelak, A. N. in Intracranial EEG: A Guide for Cognitive Neuroscientists (ed. Axmacher, N.) 671–682 (Springer, 2023); https://doi.org/10.1007/978-3-031-20910-9_42 Reliable analysis of single-unit recordings from the human brain under noisy conditions: tracking neurons over hours Duplicate detection of spike events: a relevant problem in human single-unit recordings LeGUI: a fast and accurate graphical user interface for automated detection and anatomical localization of intracranial electrodes FieldTrip: open source software for advanced analysis of MEG Automated analysis of breathing waveforms using BreathMetrics: a respiratory signal processing toolbox I know what I like when I see it: likability is distinct from pleasantness since early stages of multimodal emotion evaluation The VideoToolbox software for visual psychophysics: transforming numbers into movies Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe Single-neuron mechanisms of neural adaptation in the human temporal lobe Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex What determines the capacity of autoassociative memories in the brain A solution to dependency: using multilevel analysis to accommodate nested data Random effects structure for confirmatory hypothesis testing: keep it maximal Download references Kehl, Sina Mackay, Rainer Surges & Florian Mormann Matthias Schneider & Valeri Borger Spehr planned and designed the analyses with contributions from K.O.; M.S.K wrote the paper with contributions from K.O All of the authors discussed the results and commented on the manuscript The company had no influence on the study design or interpretation of the results and did not provide any financial support The other authors declare no competing interests Nature thanks the anonymous reviewers for their contribution to the peer review of this work. Peer reviewer reports are available Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Microwires inserted through the shaft of the hollow clinical macro electrode protrude from the tip of the electrode The electrode features eight cylindrical clinical platin-iridium contacts while the remaining contacts are equidistantly spaced along the electrode Illustration of the electrode geometry and dimensions Scanning electron microscopy images of the tip of a microwire before (top) and after cutting (bottom) Mean odour ratings for each participant and odour Odours are sorted from most to least liked (left to right) and participants are organized by average valence ratings (top to bottom) Average behavioural odour identification performance for each participant and odour Odours are sorted from most to the least accurately identified (left to right) and participants are organized by their mean identification performance (top to bottom) Examples of odour-modulated neurons across recording sites exhibiting significantly different firing rates in response to distinct odours (one-way ANOVA of z-scored firing rates with odour identity Spike shape density plots of each neuron are shown in the top of each panel amygdala neuron: F15,112 = 5.5; P = 3.0⋅10−8; f EC neuron: F15,112 = 6.8; P = 3.1⋅10−10; h hippocampus neuron: F15,112 = 3.4; P = 0.00012 Distribution of odour-modulated neurons after omitting the neutral odour stimuli for the definition of odour-modulated neurons (PC: 36.8 ± 4.2% P = 0.42; one-sided Wilcoxon signed-rank against chance) Population of odour-modulated neurons identified with and without the odourless control showed a highly significant overlap (P < 10−10 in a two-sided binomial test with k = 353 n = 2,416 neurons and Pchance = (406/2,416)⋅(378/2,416)) Respiration was measured with thoracic (upper Respiration signals were amplified and recorded using the Neuralynx ATLAS system ensuring reliable temporal synchronization with neural recordings Performance (adjusted R2) of linear regression models predicting neuronal firing (z-scores) based on odour identity or odour identity combined with respiration (inhalation depth) Adding respiratory information to odour identity did not significantly improve the model predictions of firing rates of odour-modulated neurons (odour identity & respiration (R2 = 0.194 ± 0.008) versus odour identity alone (R2 = 0.190 ± 0.008) n = 240 odour-modulated neurons with respiratory recordings odour-modulated neurons are primarily driven by odour-specific differences and not variations in respiration Averaged odour-locked respiratory signals for each individual recording session (mean ± s.e.m. Participants consistently inhaled once (single peak) during the first 2 seconds after odour onset (grey shaded area) the analysis time window used for identification of odour-modulated neurons = not significant. Diagrams were created using BioRender (a) and Noun Project (a) Odour-decoding accuracy and behavioural odour-identification performance across regions and participants averaged across sessions for each participant (coloured dots) Decoding accuracy in the hippocampus positively correlated with odour-identification performance across participants (Spearman correlation Linear regressions (black) with 95%-confidence intervals (grey) Odour identification improves with more odour-modulated neurons in the hippocampus and EC Percentage of odour-modulated neurons and performance for each recording session for different regions Percentage of odour-modulated neurons in the EC and hippocampus is positively correlated with individual performance in the odour identification task (Spearman correlation Despite the limited and variable neuron count per session image identity could be decoded significantly above chance (6.25% dashed horizontal line) across sessions in PC and hippocampus (PC: 7 out of n = 17 sessions showed significant decoding compared to 1,000 image-label-permuted data P = 0.00061; hippocampus: 10 out of n = 20 P = 0.21; right-sided binomial test with Pchance = 0.05 regions with ≥ 2 neurons in recordings with both olfactory and visual task) Cross-modal decoding per session trained on images and evaluated on odours (e) revealed significant cross-modal coding in PC and amygdala (Image-to-odour: PC: 4 out of n = 17 sessions P = 1; Odour-to-image: PC: 0 out of n = 17 P = 1; right-sided binomial test with Pchance = 0.05 regions with ≥ 2 neurons in recordings with both olfactory and visual task as in (d)) Population sparseness index in response to odours for each recording session and odour (mean ± s.e.m Sparseness significantly differed across recording sites (one-way ANOVA All pairwise tests significant (P < 0.05) following Tukey’s honestly significant difference procedure except the pairwise comparison of amygdala and hippocampus (P = 0.11) Average respiratory traces (mean ± s.e.m.) for each odour presentation (trials 1 to 8) across 13 recording sessions black) for each odour presentation (1 to 8) and recording session (coloured dots) Inhalation depth was consistent across odour repetitions (one-way ANOVA n = 13 recording sessions with 8 trials each) Average response strength for repeated odour presentations across all recorded neurons in each anatomical region (mean ± s.e.m.) Odour repetitions are approximately 5 min apart Insets depict the mean response slopes per region (mean ± s.e.m.) Significance is based on a two-sided Wilcoxon signed-rank against a slope of zero (PC: n = 276 neurons neurons with a non-zero pre-odour baseline firing rate) First-trial effect in the human piriform cortex in black) of odour-modulated neurons between consecutive trials we calculated the differences of firing rate between successive trials (i.e. Firing rate changes were significantly different across trials and regions (one-way ANOVA PC neurons showed the most pronounced decline in firing rate from first to second trial as indicated by the blue cross and error bar All 27 pairwise comparisons (blue cross versus each of the remaining crosses) were statistically significant (P < 0.05) after Tukey’s correction for multiple comparisons across all n = 378 (binomial coefficient for selecting 2 out of 27) pair-wise comparisons The y-axis is truncated to display 99% of the data to improve visibility Mean spike peak amplitude distribution (mean ± s.e.m.: 44.8 ± 0.5µV Isolation distance (mean ± s.e.m.: 66 ± 12 for the 1786 clusters for which this measure could be calculated) Chance level (6.25%) shown as dashed horizontal line Note that with 8-32 microwires per anatomical target region it is rarely possible to simultaneously record the activity of 30 or more neurons per participant Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41586-024-08016-5 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Signal Transduction and Targeted Therapy (2024) Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. warning that a lack of response could jeopardize their future at the club: The sporting director, Sebastian Kehl, is not playing games anymore. With his job at risk, while some names are already speculated in the media as his likely successor, the former BVB legend did not spare criticism in an interview for Ruhr Nachrichten BVB It is indeed a more than fair warning, especially with so many players getting into their contract year; therefore Kehl even reinforced his point in a more severe tone asking for a quick response in an upcoming month that will feature hard-to-beat opposition like Bayern Münich and FC Barcelona: As much as Kehl is also attempting to save his own neck with an interview like this his message clearly reverberates within the administration mainly with the possibility of staying out of European competition next year Kehl sounds more like a frustrated captain in the locker room as he understands the standard the club should be aiming for: and things could (or will) definitely change at Signal Iduna Park very soon © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER It is indeed a more than fair warning, especially with so many players getting into their contract year; therefore The BVB sporting director had some severe criticism for the team's current form and sent a direct message to the ones who need to prove themselves for next season Amy Kehl of 119 Strecker Hill poses with the white oak tree that fell Sunday at her home An old tree that was part of a prominent Marietta resident’s history is now itself history The white oak in front of 119 Strecker Hill that once was the residence of S the present-day owner of the house built in 1937 She believes the tree may be from 125 to 150 years old The tree was there before the house was constructed Kehl wanted the event chronicled because of Hoag’s prominence in the history of Marietta Hoag also was an amateur photographer and his collections are at Marietta College originally constructed in 1892 and known as the Bellevue Durwood Hoag built this home in 1937 in Marietta Hoag’s family was prominent in Marietta and once owned the Lafayette Hotel Kehl was planning to have the tree removed “It was the trademark of the home,” Kehl a teacher of talented and gifted students in Marietta “It’s a miracle that it cleared the house,” she said “It landed on a fence that needed to be replaced anyway.” Kehl said she was at home when the tree fell “I was still inside clueless to what happened,” Kehl said “I thought it was my cat running through the house.” “It was a beautiful sunny day,” she said the clamor caused by the falling tree drew the interest of deer from the nearby woods “You wouldn’t believe all the deer that came out,” she said The Marietta Water Department and Triton Construction will be connecting the new North Hills transmission line on .. | https://www.mariettatimes.com | 740-373-2121 Metrics details Databases that link molecular data to clinical outcomes can inform precision cancer research into novel prognostic and predictive biomarkers cancer outcomes are typically recorded only in text form within electronic health records (EHRs) Artificial intelligence (AI) models have been trained to extract outcomes from individual EHRs patient privacy restrictions have historically precluded dissemination of these models beyond the centers at which they were trained the vulnerability of text classification models trained directly on protected health information to membership inference attacks is confirmed A teacher-student distillation approach is applied to develop shareable models for annotating outcomes from imaging reports and medical oncologist notes ‘Teacher’ models trained on EHR data from Dana-Farber Cancer Institute (DFCI) are used to label imaging reports and discharge summaries from the Medical Information Mart for Intensive Care (MIMIC)-IV dataset ‘Student’ models are trained to use these MIMIC documents to predict the labels assigned by teacher models and sent to Memorial Sloan Kettering (MSK) for evaluation The student models exhibit high discrimination across outcomes in both the DFCI and MSK test sets Leveraging private labeling of public datasets to distill publishable clinical AI models from academic centers could facilitate deployment of machine learning to accelerate precision oncology research key phenotypic variables needed for this purpose are generally recorded only in unstructured text in routine practice The manual medical records review needed to obtain these clinical variables is too slow and resource-intensive to scale further To make full use of clinico-genomic datasets natural language processing (NLP) and artificial intelligence (AI) methods are needed to extract key validated oncologic phenotypes from longitudinal EHR data which is analogous to reconstructing private information such as patient names in medical records This would involve training a “teacher” model on PHI to extract clinical outcomes and then applying that model to a publicly available PHI-free text dataset to generate labels for that public database a large language model could serve as the “teacher” by prompting it to label such a public dataset A “student” model could then be trained using the public text to predict the labels assigned by the teacher(s) In this work, a teacher-student framework is used to train AI/NLP models to extract clinical outcomes from imaging reports and medical oncologist notes at one academic cancer center for evaluation at a second center for patients in a multi-institutional clinico-genomic cohort Fig. 1. including training and evaluation of a teacher model on DFCI data application of the teacher model to label MIMIC documents training a student model on the MIMIC document labels and evaluation of the student model in the DFCI and MSK test sets Patient and clinical document characteristics are provided in Table 1 The DFCI cohort consisted of patients with seven cancer types including 3213 patients with 37,274 annotated imaging reports and 3588 patients with 39,191 annotated oncologist notes These data were divided randomly at the patient level into 80% training The MSK cohort consisted of patients with five cancer types including 2672 patients with 24,472 annotated imaging reports and 3617 patients with 40,701 annotated oncologist notes The MIMIC dataset consisted of 217,642 imaging reports and 141,377 discharge summaries that met our inclusion criteria DFCI test set: N = 3405 reports for 305 patients MSK test set: N = 24,472 reports for 2672 patients Bar heights represent point estimates for the area under the receiver operating characteristic curve (AUROC) and error bars represent 95% bootstrap confidence intervals around that estimate Source data is provided as a Source Data file (worksheet Figure 2) DFCI test set N = 3405 reports for 305 patients Bar heights represent point estimates for the area under the precision-recall curve (AUPRC) The null value for the AUPRC for each outcome is equivalent to the outcome probability in each dataset Source data is provided as a Source Data file (worksheet Figure 3) Imaging report model performance as measured by F1 scores is provided in Fig. 4. The best F1 scores for DFCI-imaging-teacher and DFCI-imaging-student were similar when evaluated on DFCI test set imaging reports and were higher than those achieved by Llama-imaging-student. Bar heights represent point estimates for the best F1 score Null values for the best F1 score are calculated by assuming a “model” that always guesses that an outcome is present and they are calculated as (2 × p(outcome)) / (p(outcome) + 1) Source data provided as a Source Data file (worksheet Figure 4) DFCI test set: N = 3382 reports for 345 patients MSK test set: N = 40,701 reports for 3617 patients Source data provided as a Source Data file (worksheet Figure 5) Source data provided as a Source Data file (Figure 6) Medical oncologist note model performance as measured by the best F1 score is described in Fig. 7. Comparative performance patterns were similar to those observed for the AUPRC metric. and they are calculated as (2 ×  p(outcome)) / (p(outcome) + 1) Source data provided as a Source Data file (Figure 7) Model performance within individual cancer types for all three metrics (AUROC, AUPRC, and F1 score) is detailed in Supplementary Tables 1-21 A simple formulation of a membership inference attack on the oncologist note classification models was performed to demonstrate that classification teacher models trained on protected health information can leak private data An attack model trained on labels and outputs from an overfit DFCI-medonc-teacher model yielded an AUROC of 0.71 (95% CI 0.59 to 0.82) for discriminating whether notes were used to train the teacher this approach could not be used to attack a DFCI-medonc-student in the same way The student could not be successfully fit using the MIMIC discharge summaries to predict the outputs from the overfit teacher This student model’s outputs converged to constant values such that the attack model yielded an uninformative AUROC of 0.55 (95% CI To demonstrate the applicability of the teacher-student distillation process beyond classification/information extraction tasks another new teacher model (DFCI-prognosis-teacher) was trained to predict survival using individual imaging reports from the DFCI training set It achieved an c-index of 0.76 in the DFCI test set DFCI-prognosis-teacher was then used to label the MIMIC imaging reports described above yielding mortality risk scores for those reports A DFCI-prognosis-student model was trained to predict those teacher-generated labels; this model also achieved a c-index of 0.76 in the DFCI test set The DFCI-prognosis-student model was then transferred to MSK for evaluation on its imaging reports achieving a c-index of 0.76 at MSK as well These results indicate that a “teacher-student” approach can be used to develop shareable AI/NLP models to extract structured cancer outcome variables from EHRs for creation of multi-site clinico-genomic datasets a ‘teacher’ model is trained on PHI from one or more institutions and used to label publicly available datasets to facilitate the training of a ‘student’ model that predicts those labels These student models do not expose PHI directly to the risk of memorization and data leakage facilitating deployment across health systems demonstrating the need for shareable customized models even as general AI technology evolves rapidly external generalizability of the DFCI-imaging-student model to MSK imaging reports appeared somewhat better than external generalizability of the DFCI-medonc-student model to MSK oncologist notes for progression and response outcomes as measured by the AUPRC and F1 This could be due in part to the more uniform nature of imaging reports across sites compared to oncologist notes as well as to the closer match between MIMIC imaging reports and DFCI imaging reports than between MIMIC discharge summaries and DFCI oncologist notes Federated learning seeks to preserve the privacy of training data by keeping each site’s data housed locally and only sharing model weight updates at each training step weight updates in federated learning have been derived from private training data such that there may still be regulatory barriers to deployment in healthcare due to privacy risks This demonstrates the need for privacy-protecting approaches to model training PATE would involve training several individual teacher models on private datasets at individual centers then using an ensemble of these models to label a shared public dataset with an injection of additional privacy-preserving noise training a student model on the public dataset to predict the ensemble labels The teacher-student distillation approach has the intuitive benefit for regulatory stakeholders of yielding shared models that have not been directly exposed to PHI This could specifically facilitate clinical annotation of genomic data using common AI models in multi-institutional consortia such as AACR Project GENIE addressing the critical barrier to research using such datasets historically posed by the lack of outcomes data at scale We focused specifically on the task of cancer outcome extraction in this analysis Evaluating the performance of the teacher-student approach for other tasks would require further research such as whether a given EHR document describes progression of disease It is quite likely that a distillation approach applied to a task that involves predicting possible PHI Quantifying the extent of this risk also requires further investigation a teacher-student distillation approach can be used to distill AI/NLP models to extract clinical variables from the EHR across cancer centers without publishing models trained on PHI This technique could significantly expand the scale of clinical datasets available for precision oncology research Collection of data at DFCI and MSK was approved by the Dana-Farber Harvard Cancer Center Institutional Review Board and the Memorial-Sloan Kettering Institutional Review Board respectively Memorial Sloan Kettering Cancer Center (MSK) and Dana-Farber Cancer Institute (DFCI) are the two largest contributors to GENIE DFCI annotations were split at the patient level into training (80%) MSK annotations were used only for model evaluation Reports were truncated at the maximum BERT sequence length of 512 tokens Oncologist notes were left-truncated at the maximum Longformer sequence length of 4096 tokens were tuned manually based on performance in the validation/tuning set Final models were evaluated in the test set The loss function applied for each label was the binary cross entropy loss the DFCI-imaging-teacher and DFCI-medonc-teacher models were used to label radiology reports and discharge summaries MIMIC radiology reports were restricted to documents addressing cancer or its absence by filtering for text including the strings “cancer” and to cancer-relevant imaging modalities by additionally requiring the strings “‘ct” MIMIC discharge summaries were restricted to documents addressing cancer or its absence by requiring the strings “cancer” or “malignan*” DFCI-imaging-teacher inference was then run on the MIMIC radiology reports yielding the predicted log odds of each of the ten imaging report labels DFCI-medonc-teacher inference was run on the MIMIC discharge summaries yielding predicted log odds of each of the three medical oncologist note labels In contrast to the common distillation paradigm our student models had the same underlying architecture as the teacher models but were freshly trained from BERT-base-uncased and ClinicalLongformer so they were not exposed to PHI during training Student model hyperparameters were manually tuned based on performance among patients in the validation/tuning set of PHI-containing imaging reports and oncologist notes from DFCI Student model performance was then evaluated in the held-out DFCI BPC PHI test set student model weights and inference code were shared with MSK which evaluated the models’ performance on their own private BPC-labeled documents Student models (Llama-student-imaging and Llama-student-medonc) with the same architectures as DFCI-imaging-student and DFCI-medonc-student were then trained on the MIMIC samples to predict the Llama-assigned labels to facilitate fair comparison between the DFCI-teacher and Llama-teacher labeling strategy without confounding by training set size we retrained versions of DFCI-imaging-student and DFCI-medonc-student on the same samples of 20000 MIMIC documents each yielding ‘DFCI-imaging-student-sample’ and ‘DFCI-medonc-student-sample’ models Performance of these student models was then evaluated in the same way as the student models trained to predict labels assigned by the DFCI teachers Model training and inference were performed using Pytorch A visual depiction of our overall supervised teacher-student approach is provided in Fig. 1 to illustrate the applicability of the teacher-student distillation approach to tasks beyond information extraction and classification a BERT-based model (DFCI-prognosis-teacher) was trained to predict survival using the text of individual imaging reports for patients in the DFCI training set A negative log-likelihood loss accommodating censored data was applied Performance was evaluated in the test set using the c-index and another student (DFCI-prognosis-student) was trained to predict those labels Performance of DFCI-prognosis-student was then evaluated in both the DFCI and MSK test sets Each human annotation-derived outcome label was binary and raw model outputs corresponded to the predicted log odds of each outcome The primary model outcome metrics was the area under the receiver operating characteristic curve (AUROC) the area under the precision-recall curve (AUPRC) The best F1 score was defined based on the best F1 threshold in the dataset being evaluated Evaluation was performed on a per-document basis Metrics were compared to null values for each outcome the prevalence of an outcome in the evaluation dataset the null value is obtained by simply always guessing the positive class and corresponds to 2 × p(outcome) / (p(outcome) + 1) To evaluate the vulnerability of the teacher and student models to a membership inference attack a version of the oncologist note teacher classification model was trained and overfitted to a sample of 100 notes from the DFCI PHI training dataset We then pulled a sample of 100 notes from the DFCI PHI training/validation dataset Inference using the overfit teacher model was performed on all 200 notes A simple logistic regression attack model was then trained on 60% of these 200 notes to predict whether a given note was in the teacher’s training dataset Inputs to the attack model included the true manual labels (any cancer and the log odds of each of those outcomes generated by the teacher The attack model was then evaluated on the remaining 40% of the note sample using the AUROC metric to capture its ability to discern whether notes were used to train the teacher The overfit teacher was used to re-label the MIMIC discharge summary dataset We then attempted to train a version of the student model to predict the overfit teacher labels on those discharge summaries and train a new attack model for the student it in the same way among patients who underwent tumor next-generation sequencing (NGS) for their cancers patients whose tumors underwent NGS on a research basis provided written informed consent; those whose tumors underwent NGS on a standard-of-care clinical basis were eligible based on a waiver of informed consent given the minimal risk of the current study to participants all patients provided written informed consent Race and ethnicity were defined based on institutional medical record systems as reported by patients when they registered for clinical care Patients were not compensated for participation Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Leveraging digital data to inform and improve quality cancer care AACR Project GENIE: powering precision medicine through an international consortium Project GENIE Announces Biopharma Collaboration. Cancer Discov. 2020. https://doi.org/10.1158/2159-8290.CD-NB2019-144 AACR project GENIE: 100,000 cases and beyond Artificial intelligence-aided clinical annotation of a large multi-cancer genomic dataset Assessment of deep natural language processing in ascertaining oncologic outcomes from radiology reports Natural language processing to ascertain cancer outcomes from medical oncologist notes Clinical inflection point detection on the basis of EHR data to identify clinical trial-ready patients with cancer Health system-scale language models are all-purpose prediction engines Arbour K. C., et al. Deep learning to estimate RECIST in patients with NSCLC treated with PD-1 blockade. Cancer Discov. https://doi.org/10.1158/2159-8290.CD-20-0419 (2020) Accelerated curation of checkpoint inhibitor-induced colitis cases from electronic health records A critical assessment of using ChatGPT for extracting structured data from clinical notes Does BERT pretrained on clinical notes reveal sensitive data 2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies 946–959 (Association for Computational Linguistics Neural networks memorise personal information from one sample Elmahdy A., Inan H. A., Sim R. Privacy leakage in text classification: a data extraction approach. Preprint at arXiv http://arxiv.org/abs/2206.045919 Membership inference attacks against machine learning models In 2017 IEEE Symposium on Security and Privacy (SP) (IEEE Cloud-based federated learning implementation across medical centers Privacy-preserving deep learning NLP models for cancer registries Hinton G., Vinyals O., Dean J. Distilling the knowledge in a neural network. Preprint at arXiv http://arxiv.org/abs/1503.02531 (2015) Large language model capabilities in perioperative risk prediction and prognostication BERT: pre-training deep bidirectional transformers language understanding NAACL-HLT 4171–4186 (Association for Computational Linguistics Beltagy I., Peters M. E., Cohan A. Longformer: the long-document transformer. Preprint at arXiv https://doi.org/10.48550/ARXIV.2004.05150 (2020) OpenAI. GPT-4 Technical Report. Preprint at arXiv http://arxiv.org/abs/2303.08774 (2023) Touvron H., et al. Llama 2: Open foundation and fine-tuned chat models. arXiv http://arxiv.org/abs/2307.09288 (2023) Yang C., et al. Large language models as optimizers. Preprint at arXiv http://arxiv.org/abs/2309.03409 (2023) Membership inference attacks and defenses in classification models Eleventh ACM Conference on Data and Application Security and Privacy (ACM APRIL: finding the Achilles’ heel on privacy for vision transformers In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) 10041–10050 (IEEE Communication-efficient learning of deep networks from decentralized data 20th International Conference on Artificial Intelligence and Statistics (AISTATS) (JMLR Papernot N., et al. Scalable Private Learning with PATE. Preprint at arXiv http://arxiv.org/abs/1802.08908 (2018) Papernot N., Abadi M., Erlingsson Ú, Goodfellow I., Talwar K. Semi-supervised Knowledge Transfer for Deep Learning from Private Training Data. Preprint at http://arxiv.org/abs/1610.05755 (2016) A scalable quality assurance process for curating oncology electronic health records: the project genie biopharma collaborative approach Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support a freely accessible electronic health record dataset and PhysioNet: components of a new research resource for complex physiologic signals Abstract 5721: Automated annotation for large-scale clinicogenomic models of lung cancer treatment response and overall survival In 31st Conference on Neural Information Processing Systems (NIPS Transformers: state-of-the-art natural language processing 2020 Conference on Empirical Methods in Natural Language Processing: System Demonstrations 38–45 (Association for Computational Linguistics A comparative study of pretrained language models for long clinical text In 7th International Conference on Learning Representations (ICLR Meta Llama 3. Meta Llama. https://llama.meta.com/llama3/ (2024) Download references This work was funded by the National Institutes of Health/National Cancer Institute (R00CA245899 ZB); the United States Department of Defense (W81XWH-22-1-0086 KLK); and the American Association for Cancer Research (KLK Choueiri is supported in part by the Dana-Farber/Harvard Cancer Center Kidney SPORE (2P50CA101942-16) and Program 5P30CA006516-56 the Kohlberg Chair at Harvard Medical School and the Trust Family Hinda and Arthur Marcus Fund and Loker Pinard Funds for Kidney Cancer Research at DFCI The content was developed or derived using the PRISSMM™ system licensed and enhanced by Memorial Sloan-Kettering Cancer Center Memorial Hospital for Cancer and Allied Diseases and Sloan-Kettering Institute for Cancer Research (collectively “MSK”) Original system and improvements © 2019-2022 Dana-Farber Cancer Institute Additional functionality and enhancements © 2023 MSK and all associated logos are trademarks™ or registered® trademarks of MSK developed and conducted the analyses in the study and wrote the manuscript participated in the external validation of trained models Trukhanov provided assistance in manuscript review and revision developed the clinical data model used in this study here are no patents related to this research Kehl reports funding from the American Association for Cancer Research to his institution related to this research and honoraria from UpToDate and travel sponsored by Meta in the context of a grant submission process unrelated to this research Choueiri reports institutional and/or personal He also reports institutional patents filed on molecular alterations and immunotherapy response/toxicity and Bicycle; committee participation in NCCN He reports that medical writing and editorial assistance support may have been funded by Communications companies in part He reports that he has mentored several non-US citizens on research projects with potential funding (in part) from non-US sources/Foreign Components His institution (Dana-Farber Cancer Institute) may have received additional independent funding of drug companies or/and royalties potentially involved in research around the subject matter Bakouny reports Honoraria from UpToDate; serving as Associate Editor at Journal of Clinical Oncology Clinical Cancer Informatics (JCO CCI); serving as co-chair of the American Society of Clinical Oncology’s International Medical Graduate Community of Practice (ASCO IMG CoP); and serving as co-founder of the IMG Oncologists nonprofit non-governmental organization Schrag reports funding from AACR to her institution related to this research Nichols reports funding from AACR to her institution related to this research The other authors have no competing interests to disclose Nature Communications thanks Moritz Gerstung reviewer(s) for their contribution to the peer review of this work Download citation DOI: https://doi.org/10.1038/s41467-024-54071-x a shareable link is not currently available for this article Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research Sign InJoinKehl speaks on Brandt's uncertain future | OneFootballBulinews Borussia Dortmund sporting director Sebastian Kehl has commented on the future of Julian Brandt following recent speculation about a summer move and he’s an incredibly important player for us," Kehl told Sky Germany "After the season, like with all other matters, we will address his situation. I know he’s 100 percent BVB - and players like him are what we need." Related NewsBrandt likely to remain at Dortmund, says Kehl Borussia Dortmund face tough Julian Brandt call with no clear backup plan Facts: Brandt leads the way, Nmecha cleans up, Guirassy and Adeyemi on fire Report: Guirassy committed to Dortmund despite €70m release clause The Bulls beat the Black-and-Yellows in a match marked by critical defensive mistakes and missed opportunities from BVB Borussia Dortmund manager Niko Kovač was straightforward about his opinion of the result: Borussia Dortmund summed up another Bundesliga defeat this season following an agonizing loss to Leipzig where the Bulls dominated in terms of possession and chance creation BVB's second half was a tremendous upgrade even with Openda's early header to make it two to the homeowners The Black-and-Yellows had a 3.06xG in this match and no goals scored as the Croatian manager also commented on his team's wasted chances to score and make a comeback from Leipzig's 2-nil lead: Kovač was not only disappointed about the lack of goals but his record as a BVB manager in the league has been nothing but lackluster Dortmund has now more defeats than wins in the current Bundesliga season while Kovač has lost four and won two matches against sides like Union Berlin Niko Kovač tried to find the positives from yesterday's 2-nil loss to Leipzig mainly highlighting the team's effort in the second half: How did Kovač find ways to pay compliments to a defeat like that mainly because the team was depending too much on long balls and individual plays to create chances against Leipzig BVB sporting director Sebastian Kehl had his own thoughts on the overall performance: A more self-conscious perspective from Leipzig's matchup indeed but it still lacks some explicit criticism of the team's management this season and the current standards the club has put itself at BVB will have the international break to regroup which apparently is not Kehl's primary wish at the moment: I am unaware of what exactly Kehl is referring to when he says the team is "continuing to improve in many areas." Still Borussia Dortmund will have a boom-or-bust type of weeks after the break where the Black-and-Yellows will play Freiburg and Bayern Münich away and FC Barcelona twice for the Champions League quarterfinals A couple of weeks that could potentially put an end to any aspirations for European football next season and mercifully finishing a 2024/2025 season that seemed to be destined for failure BVB's sporting director and manager gave some truthful post-match interviews from yesterday's defeat in Leipzig Sebastian Kehl remains confident that Borussia Dortmund will be able to turn things around with under-fire head coach Nuri Sahin at the helm Borussia Dortmund fell to yet another defeat on Tuesday as they were eliminated from the DFB-Pokal by VfL Wolfsburg the club's fourth in their last five matches who has endured a difficult start to life as BVB head coach In what was a scrappy game from the outset, Wolfsburg scored in the 117th minute to knock Borussia Dortmund out of the DFB-Pokal in the second round Calls for the Borussia Dortmund bosses to sack Sahin are getting louder with every such performance and result But Sebastian Kehl maintains faith in his former BVB midfield partner's ability to get the team back on track When asked what the defeat means for Sahin's future "This is not a situation that BVB hasn't overcome in the past The squad is currently small due to injuries but we'll do everything we can to win this game [against Leipzig]." A tough test lies in store for Borussia Dortmund this weekend as they go up against their former head coach Marco Rose and his in-form RB Leipzig side the Black and Yellows have a perfect record at the Westfalenstadion this season And Nuri Sahin will certainly hope that it continues on Saturday ","https://fansided.com/",{"alt":"5y","src":"5z","url":"60"},{"type":"5x","value":"61"},"link","Minute Media","https://www.minutemedia.com/",{"text":"64","url":"65"},{"type":"63","value":"66"},"All Rights Reserved Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands Joey has written about Borussia Dortmund for several years and has been a fan of the German club much longer His work has previously appeared on SB Nation's Fear The Wall and his creative work has been published internationally Joey's stories and essays can be found across the internet and in print from Half and One Journal Joey holds a BA in Creative Writing from Susquehanna University and an MFA in Creative Writing from Alma College Joey enjoys writing fiction and playing Disc Golf In what was a scrappy game from the outset, Wolfsburg scored in the 117th minute to knock Borussia Dortmund out of the DFB-Pokal in the second round Sebastian Kehl is set to sign a new contract as Borussia Dortmund sporting director Kehl has agreed to extend his contract until 2027 following talks with BVB managing director for sport Lars Ricken Kehl's current deal is due to expire at the end of the season The former Borussia Dortmund player has been in the role since the summer of 2022 Dortmund's sporting director Sebastian Kehl (L) and Dortmund's managing director Lars Ricken talk ahead of the German Bundesliga soccer match between Borussia Dortmund and Bayer Leverkusen at Signal Iduna Park. Bernd Thissen/dpaDPAApril 9, 2025 at 8:26 AM UTC·1 min readBorussia Dortmund managing director for sport Lars Ricken has said that the club wants to continue with coach Niko Kovac and sporting director Sebastian Kehl beyond what has largely been an underwhelming season. "This is our clear aim," Ricken told Wednesday's papers of the Funke publishing house, speaking of an "intensive cooperation" with Kehl. Kehl's contract at the former Bundesliga champions and Champions League winners was renewed until 2027 in January. Kovac replaced Nuri Sahin in February on a deal until 2026. "When we renewed Sebastian's contract it was important for me that we get the maximum out of the season and head into the future together. I made that very clear at the time. Nothing has changed concerning this goal," Ricken said. Kehl has come under criticism over the composition of the squad in a season where Dortmund are eighth in the Bundesliga and face missing a top four finish which would guarantee Champions League football. Kovac has led the team into the Champions League quarter-finals where they were to face Barcelona later Wednesday. In the Bundesliga, he has partly steadied the ship but there has still been inconsistency. Ricken however praised Kovac's work, saying: "Under Niko's leadership we have the best defensive tackle ratio in the league. We are creating more scoring opportunities, allow much less, and have reduced the amount of goals we concede." Sebastian Kehl said that Nuri Sahin retains the full support of those in charge After Borussia Dortmund fell to their third defeat of the Bundesliga season Nuri Sahin has certainly not had an ideal start to life as Borussia Dortmund head coach, with the team languishing in seventh place in the Bundesliga standings. The latest setback arrived on Saturday as the Black and Yellows fell to a 2-1 defeat to FC Augsburg extending their woeful run of form away from home The defeat came just days after Borussia Dortmund blew a two-goal lead away to Real Madrid and ended up losing 5-2 With the DFB-Pokal second round tie against VfL Wolfsburg and the Bundesliga clash against RB Leipzig coming up But those in charge at Borussia Dortmund retain confidence in the former midfielder's ability to turn things around. Following the defeat to FC Augsburg, BVB sporting director Sebastian Kehl gave his backing to Sahin. "He has our full confidence, no question about it," Kehl told Sky Sport after the game (via Kicker) "We took a new direction in the summer But there is no alternative but to keep working hard." I see the coach and his team working with the squad every day Nuri prepares the team meticulously and also worked out a match plan for [Augsburg] the players have to implement it on the pitch." Borussia Dortmund have certainly not looked convincing in any of their games in the Bundesliga so far this season And they are yet to record their first away win of the season in the league ","https://fansided.com/",{"alt":"5x","src":"5y","url":"5z"},{"type":"5w","value":"60"},"link","Minute Media","https://www.minutemedia.com/",{"text":"63","url":"64"},{"type":"62","value":"65"},"All Rights Reserved Nuri Sahin has certainly not had an ideal start to life as Borussia Dortmund head coach, with the team languishing in seventh place in the Bundesliga standings. The latest setback arrived on Saturday as the Black and Yellows fell to a 2-1 defeat to FC Augsburg But those in charge at Borussia Dortmund retain confidence in the former midfielder's ability to turn things around. Following the defeat to FC Augsburg, BVB sporting director Sebastian Kehl gave his backing to Sahin. "He has our full confidence, no question about it," Kehl told Sky Sport after the game (via Kicker) “We lacked a little conviction” – Sebastian Kehl analyses Borussia Dortmund defeatGet German Football NewsJanuary 11 2025 at 6:21 AM UTC·1 min read“Maybe we lacked a little conviction,” Sebastian Kehl somewhat surprised many with his statement after Borussia Dortmund’s first Bundesliga defeat at home this season Conceding three goals to Bayer Leverkusen in the opening 20 minutes wasn’t in their gameplan but BVB’s sporting director believed his squad “were extremely unlucky.” “We got off to a very bad start,” said Kehl “Leverkusen scored very effectively but we didn’t defend well either We made it a little too easy for Leverkusen “And yet you always had the feeling that there was more in it today because I don’t think Leverkusen were particularly good We still had hope that we would equalise.” especially in the dying embers of the game Serhou Guirassy’s 79th minute penalty put Dortmund to within one goal of Leverkusen but despite dominating possession throughout the game they failed to seriously test Lukas Hradecky who looked uncomposed in the closing stages GGFN | Daniel Pinder Borussia Dortmund suffered their third straight defeat in 2025 as they went down 2-0 to Eintracht Frankfurt on Friday night The defeat piles further pressure on under-fire head coach Nuri Sahin, with Dortmund sitting in 10th place in the Bundesliga ahead of the weekend's remaining fixtures in Germany's top flight. Dortmund sporting director Sebastian Kehl insisted after the game that the 36-year-old still has the backing of the club's management "We will not escape criticism and we will continue to work on ourselves." "The arguments are performance and results I don't need confirmation that I'm in office every three days “You can either doubt yourself or you can accept this catastrophic situation and stand your ground I won't ask for anything else until the last day I'm here as coach.” Sebastian Kehl: "We've shown that we can surpass ourselves"Borussia DortmundApril 8 2025 at 2:15 PM UTC·3 min readSebastian Kehl on the approach to the game against Barcelona: "We'll need to be courageous and to have phases of possession in order not to give Barcelona too much space they score an unbelievable amount of goals We've also done that in the Champions League They have the top goalscorer in the Champions League in Raphinha – but we have the second-top goalscorer We're aware of Barcelona's strengths but we will still create opportunities to switch the play time and time again They will offer up spaces and we will try to attack them." …the Olympic Stadium in Barcelona: "I believe that FC Barcelona have long since gotten used to this stadium and have played some really good games there We know that it will become heated and we know that they're a really good team we have to go into this match with the right attitude and with the right intensity I can only say that we're all extremely looking forward to it and I hope that this excitement will translate into passion tomorrow too." …home advantage in the return leg: "I think that Barcelona will of course try everything tomorrow in order to put themselves in a very good position Because they know what it might be like at ours next week We have repeatedly shown in the past that we can surpass ourselves we will need a really good performance tomorrow …the 3-2 defeat to Barcelona in the league phase: "Barcelona have extreme strengths and a great many difference-makers They showed that in the match in the league phase We lost that game in the end – even though we were at least on their level in the second period and could have turned the game in a different direction All of these moments will give us hope for the two matches but they are knockout games and slightly different to a league phase game." …the absence of Nico Schlotterbeck: "It's really been a shock for us now means that he will be out of action for several months But one thing is clear: Nico will get our total support We will sorely miss him over the coming weeks and we will need him as soon as he comes back again That will of course have an impact on tomorrow's game and on the coming weeks as are we – it is a loss that weighs heavily But we will try everything tomorrow to bring him a little joy in front of the television." Patty had been employed at the Marietta Times where she worked in the Production Department for 31 years She was a member of Gilman United Methodist Church and enjoyed doing Genealogy and crocheting and shopping trips her brother Steven Kehl of Marietta and several aunts Funeral services will be held on Monday (July 15) at 11:00 am at McClure-Schafer-Lankford Funeral Home Family will greet friends on Sunday evening at the funeral home from 5 until 7 Messages of sympathy may be sent at www.Lankfordfh.com donations in her memory will be appreciated to either the Gilman United Methodist Church “Sebastian and I have known and trusted each other for many years," Kehl's colleague Lars Ricken noted in a club statement. "In recent weeks, we have had intensive discussions about content, structures, and financial issues and have now brought them to a positive conclusion. We will continue to combine all our strengths to achieve these goals. As sporting director, Sebastian has my full support on this journey." “I have extremely close ties to Borussia Dortmund and I'm very happy to continue working for this great club,” Kehl himself added. "I feel the trust that our management has in me as sporting director and I would like to thank Lars in particular for the good and constructive discussions we have had over the past few weeks. We have agreed on clear competencies and responsibilities and have large joint ambitions."  BVB still expects to sign a winger to replace Malen and a defender before February 3rd The CEO required professionalism as Kehl and Mislintat to work together to get these deals finalized Lars Ricken has put some pressure on Sebastian Kehl and Sven Mislintat to get signings done within five days before the transfer window deadline. As reported by Patrick Berger there have been some agreement issues between these two who expressed his discontent with the situation to Ricken The board now hopes for a change in the mood with Kehl and Mislintat bringing signings who can help BVB until the end of the season Watzke also told Ricken that he should restore the balanced environment to Dortmund even at the cost of eventual personnel consequences Another name who has been under fire is Matthias Sammer Ricken has reportedly advised the end of Sammer's position at the club but BVB is not expected to make any changes in personnel before the end of the transfer period has increased the pressure on the sporting department which has made no signings in this winter transfer window 2025 at 10:42 AM UTCBorussia Dortmund's sporting director Sebastian Kehl spoke about the new interim coach Mike Tullberg in his interview The defeat piles further pressure on under-fire head coach Nuri Sahin, with Dortmund sitting in 10th place in the Bundesliga ahead of the weekend's remaining fixtures in Germany's top flight. Dortmund sporting director Sebastian Kehl insisted after the game that the 36-year-old still has the backing of the club's management "We will continue in this constellation "We will not escape criticism and we will continue to work on ourselves." "The arguments are performance and results I don't need confirmation that I'm in office every three days I won't ask for anything else until the last day I'm here as coach.” Dortmund are going through a poor domestic season, ranked 11th and in danger of failing to qualify for the Champions League for the first time since 2015, and for Europe at all. They are still in the Champions League but face a difficult quarter-final tie against Barcelona next month. Dortmund play top four contenders Mainz, Freiburg and Borussia Mönchengladbach, and visit leaders Bayern Munich in their next four Bundesliga matches. Kehl told Friday's Ruhr Nachrichten paper that the coming weeks are crucial for the club and for the players, as club leaders will have a close look at "which players Borussia Dortmund can build on in the future. "Who will take on this situation now? Who faces up to it and who will take responsibility? "We now need men who are up for a challenge, who are eager to attack and don't hide. That's what the fans want to see, we owe it to them. We will take a very close look at who follows this course." No player contract expires but there could still be a squad overhaul, Kehl warned. "Being 11th in the Bundesliga is very, very unsatisfactory. For our fans, for the club, for the team and also for me personally," he said. "Our squad has caused bitter disappointment on several occasions. It has been put together for completely different expectations and demands. We have one of the most expensive squads in the Bundesliga, and we're not living up to it." Coach Niko Kovac on Friday agreed with Kehl that they will have to decide what happens in summer but that it is "now about strengthening the players so that we get everything they have out of them." Kovac urged a big effort, starting on Sunday against Mainz who in third are one of the season's surprise teams and two years ago denied Dortmund the title by holding them 2-2 on the final matchday. "We have to win this match, regardless of how we do it. We all have a responsibility. That is our focus," Kovac told reporters on Friday. "Mainz are doing a really good job. They are difficult to play and very efficient. They are on a roll. But we are playing at home and want to win this match together with our fans." Kovac said that everyone has returned healthy from the international break, that Carney Chukwuemeka and Daniel Svensson are fit again, and Felix Nmecha also nearing a return. "We have eight more games in the Bundesliga and hopefully more than two in the Champions League. We need every player. We will try to get everything out of it," Kovac said. Randal “Randy” Kehl, 78, passed away November 12, 2024, after a courageous battle with cancer. Born on January 12, 1946, Randy was the third of six children of Eileen Gibson (Kehl). Needing some direction in life, Randy entered the Navy at seventeen. After leaving the Navy, he returned to Atikokan and married his soulmate, Roberta Calder. Together they had two children, Tammy and Shayne (Cuffy). Randy and Roberta were a team for 57 years. They were the most amazing dancers and others loved to sit back and watch them move on the dance floor. Together they built a beautiful cabin and enjoyed their retirement. They loved to fish, hunt, pick blueberries, garden and drive the countryside. Randy loved to build. Early in his marriage he built furniture for his kids before turning his eye to building a garage, a new home and finally a cabin. He always had one more job to do and enjoyed being productive. Family was extremely important to Randy, and he took pride in his children and grandchildren. He was a nurturing guy, so when his children left home, he adopted dogs to shower his love on. They were part of the family, and deeply mourned when they passed away. Randy loved to swim, fish and four-wheel with his family, and supported and encouraged them to be the best they could be. He loved to sing off-tune Happy Birthday wishes and chase all the boys away from his granddaughters. Randy was known for his kindness. He was the person who brought blueberries to the elderly who couldn’t get out, and the one who held the door so others could go in first. He believed you shouldn’t say anything if it wasn’t nice, and he could be counted on to help his neighbors out if they needed a helping hand. Randy was pre-deceased by his mother Eileen and his sisters Harlene (Lorne) and Lynn (Ed). He is survived by his wife Roberta; children Tammy (Mike) and Cuffy (Glenna; grandchildren Jacqueline, Andrew, Caryss and Reese; siblings Dawn (Victor), Dale (Kathy), and Tracy (Rick); as well as several nieces and nephews. Services will be held at the Legion on Friday, November 29, at 1:00 p.m. A memorial book will be available at the service for those wishing to document their favorite story of a life well-lived. but he is confident that the team will be able to turn things around Sebastian Kehl has admitted that Borussia Dortmund's form away from home has not been good enough so far Borussia Dortmund suffered yet another defeat away from home on Saturday as they were beaten by Mainz 05 in the Bundesliga The Black and Yellows have now lost their last four away games in the league and their last six away matches across all competitions Defeats have included a 5-1 thrashing away to Stuttgart a second-half collapse against Real Madrid and abject showings away to FC Augsburg and Union Berlin The team's poor run of form when they are not being cheered on by 80,000+ fans at the Westfalenstadion has raised many eyebrows. And Borussia Dortmund sporting director Sebastian Kehl commented on their away day woes after the 3-1 defeat to Mainz 05 on Saturday "One point in five away games doesn't live up to our expectations "We want to collect a lot of points in November and December to stay in contention Everything is still relatively close in the table if you leave Bayern Munich out Other teams aren't as stable yet either but we're continuing on this path and we believe in it." While Borussia Dortmund have often looked out of sorts away from home they have won all of their matches so far at the Westfalenstadion Next up for Nuri Sahin's side is a home game against SC Freiburg followed by a trip to Dinamo Zagreb in the UEFA Champions League BVB will host Bayern Munich in what will be their toughest test of the season so far ","https://fansided.com/",{"alt":"5w","src":"5x","url":"5y"},{"type":"5v","value":"5z"},"link","Minute Media","https://www.minutemedia.com/",{"text":"62","url":"63"},{"type":"61","value":"64"},"All Rights Reserved Borussia Dortmund suffered yet another defeat away from home on Saturday as they were beaten by Mainz 05 in the Bundesliga The team's poor run of form when they are not being cheered on by 80,000+ fans at the Westfalenstadion has raised many eyebrows. And Borussia Dortmund sporting director Sebastian Kehl commented on their away day woes after the 3-1 defeat to Mainz 05 on Saturday While Borussia Dortmund have often looked out of sorts away from home, they have won all of their matches so far at the Westfalenstadion. Next up for Nuri Sahin's side is a home game against SC Freiburg, followed by a trip to Dinamo Zagreb in the UEFA Champions League. Then, BVB will host Bayern Munich in what will be their toughest test of the season so far. He mentioned that Borussia Dortmund is traveling to Portugal with a lot of anticipation and optimism and even gave some tactical spoilers on BVB's approach to facing the Lions: Dortmund's sporting director, Sebastian Kehl, revealed hardcore truths during his press conference before Tuesday's UCL matchup against Sporting Lisbon Kehl also talked about some senior players' underperformances this season the former Dortmund player tried to take the focus off Brandt and provided a broader perspective on the underperformance issues: Kehl highlighted the need to trust in the current squad since they will be the ones to take Dortmund out of this crisis: Kehl was honest about the previous underperformance worries and agreed that a few players have been below the best level He finished with a hardcore truth about Dortmund's current scenario and a so-needed acceptance of blame in which the club needs to be held accountable for this season's mistakes; something the fans craved for: In the press conference before the Champions League playoff first leg offered some intriguing insights into the club's future plans.