We recently switched our login system from requiring display names to email addresses in order to log in You must use your email address instead of your display name in order to log in Interested in learning more about the Minnesota Twins' top prospects Check out our comprehensive top prospects list that includes up-to-date stats You need to be a member in order to leave a comment Sign up for a new account in our community This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Home / Sports / Minor League Sports Urbandale native was promoted last week to Cedar Rapids Kernels CEDAR RAPIDS — Ty Langenberg has had to reassess his goals for his first season of professional baseball Mainly because he already has met one of his biggest ones The Urbandale native and former Iowa Hawkeyes pitcher was promoted to the Cedar Rapids Kernels roster last week throwing five innings and picking up a victory over the Lansing Lugnuts in Michigan I can’t lie,” Langenberg said late Tuesday afternoon prior to C.R.’s home game at Veterans Memorial Stadium against Peoria doing pretty well down there in Fort Myers so it feels good to be back in Iowa.” Langenberg is a 22-year-old right-hander whom the Minnesota Twins drafted last year in the 11th round and pitched a handful of late-season games in Fort Myers for the Rookie-level Florida Complex League Twins and the low-A Mighty Mussels as he gave up five runs in each of his first two starts But a trip to the development list between middle and late April helped him hit the reset button “I thought it was a very long learning process I’ll admit that,” Langenberg said “The first couple of starts of the season were pretty eye-opening for me to realize this is a whole different level from college Luckily I had two good pitching coaches down there and they worked with me a lot mechanically and just kind of on pitching as a whole Learning how to be a pitcher and not just a thrower.” and he went at least five innings in his final five starts allowing two or fewer runs in each of them “It was like a whole system rework,” Langenberg said of his development list stint “They were like ‘We’re going to take a step back see if we can make some changes.’ I reworked the next couple of weeks it started coming together I felt a lot better with my arm and my lower body pitch shapes and stuff were really coming together Langenberg throws from three-quarters slot with a fastball that generally sits low-90s and has hit 96 He also throws a cutter and has worked arduously on a slider a pitch he knows he needs if he wants to progress up the minor-league ladder “I wouldn’t mind staying here a little bit,” he said “But I think the goal right now is to go out there and continue to build upon the success I had at Fort Myers I’d love to see my arsenal come together consistently and see my velo creep up as well Langenberg is the first former Hawkeyes player to play professionally in Cedar Rapids since catcher Alex Dvorsky was here in 2003 where he was drafted by the Los Angeles Angels Langenberg is the first former Hawkeyes player to play pro ball in C.R after being drafted from Iowa since outfielder Jeff Jones and infielder Tony Burley played for the Cedar Rapids Reds Langenberg gave up three runs in five innings in his win over Lansing and is scheduled to start Saturday night’s game at Memorial Stadium against Peoria “A lot of family and friends should be here,” Langenberg said “It’s going to be a lot of fun.” Prep Sports & Minor League Sports Reporter. Get the Sports Newsletter The Gazette has been informing Iowans with in-depth local news coverage and insightful analysis for over 140 years independent journalism with a subscription today © 2025 The Gazette | All Rights Reserved Being a school board member is a privilege and an honor I have a dedicated interest in the welfare of all children in Anderson County and work very hard to give them opportunities to reach their full potential I am seeking re-election to the Anderson County school board and am very knowledgeable of all schools and districts in our county I work well with my fellow school board members Many wonderfull things are going on in the Anderson County Schools is starting to a build a new $25 million school in the Claxton community without any tax increase We plan to pay for the new school through our energy savings on utilities So many things have changed since I was first elected to serve on the school board We put safety first for all our students and staff All of our schools are in good condition and we have installed safety doors with bullet proof screening We have SROs (school resource officers) and registered nurses in all of our schools I am very proud to say that we have raised our pay scale for our teachers and staff This makes us more competitive with other school systems and helps us recruit and keep better teachers This year we were able to give our teachers a 4% pay raise maintenance workers and other non-certified employees the same amount middle and high school have computers that are assigned to them The board works with Comcast to provide wifi services for students living in rural areas Our school system provides free transportation and free lunches to our students and through COVID our cafeterias stayed open to feed our less fortunate students and their families I work very closely with our special student director who keeps up with our homeless population and families who need extra services We have excellent Head Start and Day Care programs One of our Day Care programs is located in Oak Ridge We also have started an afterschool program for parents who work and can't pick up their children at dismissal time Our Career and Technology program is recognized as a model by the state as an excellent program that offers students that don't go to college career opportunities in construction Our school system offers excellent services and programs to students with autism and special needs We offer intervention programs for those students needing extra support These are a few things I am proud of in the Anderson County Schools I was awarded the Master School Board Member award and I serve on a Board of Distinction that has a motto: Every Student I am so thankful for the opportunity to continue to work for all of our students in Anderson County and thankful for all of my constituents who have put their trust and faith in me is seeking re-election to the District 8 seat on the Anderson County Board of Education Metrics details For many diseases there are delays in diagnosis due to a lack of objective biomarkers for disease onset in 41,931 individuals from the United Kingdom Biobank Pharma Proteomics Project we integrated measurements of ~3,000 plasma proteins with clinical information to derive sparse prediction models for the 10-year incidence of 218 common and rare diseases (81–6,038 cases) We then compared prediction models developed using proteomic data with models developed using either basic clinical information alone or clinical information combined with data from 37 clinical assays The predictive performance of sparse models including as few as 5 to 20 proteins was superior to the performance of models developed using basic clinical information for 67 pathologically diverse diseases (median delta C-index = 0.07; range = 0.02–0.31) Sparse protein models further outperformed models developed using basic information combined with clinical assay data for 52 diseases pulmonary fibrosis and dilated cardiomyopathy single-cell RNA sequencing from bone marrow in newly diagnosed patients showed that four of the five predictor proteins were expressed specifically in plasma cells consistent with the strong predictive power of these proteins External replication of sparse protein models in the EPIC-Norfolk study showed good generalizability for prediction of the six diseases tested These findings show that sparse plasma protein signatures including both disease-specific proteins and protein predictors shared across several diseases offer clinically useful prediction of common and rare diseases rather than taking an agnostic discovery approach previous studies have not reported screening metrics compared with clinical models (without proteins) which may inform integration into health records and translational evaluation We used data from the United Kingdom (UK) Biobank Pharma Proteomics Project (UKB-PPP)—the largest proteomic experiment to date—to address the following objectives: (1) to systematically interrogate the 10-year predictive potential of the measurable plasma proteome across 218 pathologically diverse diseases over and above models based on information obtained in usual care (without and with clinical assays) and polygenic risk scores; (2) to identify disease-specific protein predictors pointing to underlying etiological mechanisms compared with those shared across diseases and (3) to determine whether the screening metrics of proteomic signatures for diseases meet those for blood assays used in current clinical practice a, Improvement in C-index by the addition of signatures comprising 5–20 proteins (coloured dots) over the benchmark clinical model (black dots). b, Comparison of DRs (at a 10% FPR) achieved by protein-based and clinical models. c, Improvement in LRs by the addition of signatures comprising 5–20 proteins (orange) over the benchmark clinical model (gray). Comparison of C-index by the addition of protein-based (orange) or biomarker-based models (blue) onto clinical risk factors We only show those diseases for which the C-index was improved significantly by addition of either proteins or clinical assays onto the clinical risk factors We present the mean C-index and the 95% CI Comparison of DRs (at a 10% FPR) achieved by protein-based and biomarker-based models Comparison of LRs for protein-based (orange) or biomarker-based models (gray) Selected proteins for the 67 improved diseases showed little evidence of being specifically enriched or under-represented among Olink panels with the exception of the cardiometabolic panel (fold change 1.58; P value = 0.001) and the oncology II panel (fold change A total of 19 of the 67 diseases showed enrichment for tissue-specific proteins (for example lymphoid tissue for MM) or certain pathways but only a few of these seemed directly related to known disease pathology such as cholesterol metabolism being enriched among proteins predicting stable angina (fold change We also observed slight upregulation of TNFSF13B expression in malignant plasma cells but because of the nonspecific gene expression profile of TNFSF13B in BM this increase contributed only minimally to its overall expression chronic obstructive pulmonary disease (COPD) we were only able to replicate the improvement by testing prediction of 20-year incidence most likely due to few incident cases within 10 years of follow-up Number of disease specialties for which a protein was selected as a predictor across the 67 diseases for which the C-index was significantly improved by a protein signature as compared with the clinical model The box with the dashed lines provide a zoomed version of the plot for proteins that were selected across four or more clinical specialties Mean model weights for each protein (normalized to the top predictor) across diseases for which it was selected as a predictor (out of the 67 improved diseases) Disease-specific proteins are shown as those selected for only one disease with a normalized weight >0.6 Platform: Protein included in the Olink Explore 1536 panels or the Olink Explore Expansion panels Here we identified the added value of a five-protein protein signature which improved discrimination by 7% over clinical risk factors + TNFRSF17 alone DRs across different FPR thresholds for selected disease examples which were identified as those most likely to benefit from proteomic prediction over clinical risk factors Dilated cardiomyopathy (protein signature: HRC Other interstitial pulmonary disease with fibrosis (protein signature: CA4 MM and malignant cell neoplasms (protein signature: FCRLB non-Hodgkin lymphoma (protein signature: BCL2 motor neuron disease (protein signature: CST5 leiomyoma of uterus (protein signature: BMP4 psoriasis (protein signature: DEFB4A_DEFB4B primary pulmonary hypertension (protein signature: NPPB primary malignancy prostate (protein signature: ADAMTS15 Our results highlight where plasma proteomic signatures may inform the need for This demonstrates the advantage and robustness of our approach Although our results point to some proteins as possible markers of multimorbidity the potential for leveraging pleiotropic proteins to develop a customized small signature for prediction across several diseases remains to be explored We observed evidence that superior model performance using proteins was achieved more often for rarer diseases and diseases for which blood is an important compartment While the pathological connections of the blood plasma proteome to the latter categories of diseases is intriguing the stronger improvement among rarer conditions might be explained by less phenotypic and molecular heterogeneity compared with common complex disorders like heart failure or type 2 diabetes (T2D) we currently lack systematic data-driven information on phenotypic risk factors for rare diseases Future work should focus on exploring the improvement of protein biomarkers over systematically identified clinical risk factors for rarer conditions Future work might explore how proteomics compares with additional omics layers of information for prediction of future disease risk although we report the largest proteomic experiment to date larger sample sizes are required to estimate detection rates for rarer diseases and over shorter clinically relevant time frames (for example depending on the underlying specific disease etiology evaluations against clinical diagnostic markers not available in UKB are required and IgA/IgG antibodies and anti-transglutaminase for celiac disease selected protein candidates might be early indicators of asymptomatic or dormant diseases processes that otherwise are associated with a significant delay in the diagnosis and recording in EHRs clinical translation will require development and validation of absolute quantification protein assays as opposed to the relative quantification provided by current proteomic platforms We also note that the preselection of proteins on the Olink Explore platform restricts the discovery space of new biomarker candidates upfront and that emerging untargeted mass spectrometry-based assays will probably reveal additional markers we observed evidence that plasma proteins are superior in the prediction of diseases belonging to certain clinical specialties infectious or highly compartmentalized (for example will require other types of tissue samples or entirely different clinical information to be better predicted we demonstrate that sparse plasma protein signatures when integrated with EHRs may offer new improved prediction over standard clinical assays for common and rare diseases through disease-specific proteins and protein predictors shared across several diseases the study design included three elements: (1) a randomized subset of 46,595 individuals; (2) 6,356 individuals selected by the UKB-PPP consortium members (‘consortium selected’) in which proteomic profiling was done on samples from the baseline assessment and (3) 1,268 individuals who participated in a COVID-19 imaging study with repeated imaging at several visits UKB has approval from the North West Multi-Centre Research Ethics Committee as a Research tissue biobank (REC reference 11/NW/0382) Participants provided written informed consent Olink relies on proximity extension assays which targets proteins by pairs of antibodies conjugated to complimentary oligonucleotides hybridization between probes enables amplification and subsequent relative quantification through next generation sequencing Protein targeting assays are grouped across four 384-plex panels: inflammation Olink’s internal controls involve an incubation (a nonhuman antigen with matching antibodies) extension (IgG conjugated with a matching oligonucleotide pair) and amplification controls (synthetic double-stranded DNA) Additional external controls are included in each plate Limit of detection values are calculated for each protein targeting assay per plate based on negative controls run in triplicate Normalized protein expression (NPX) values are generated by normalization to the extension control log2 transformation and further normalization to the plate controls Samples are flagged with a warning if NPX values from internal controls are not within ±0.3 NPX from the plate median across an abundance block or if the mean assay count for a sample is less than 500 Assays are flagged with a warning if the median from the negative control triplicated deviate more than 5 s.d We excluded (1) participants that were removed from the study and (2) samples that were defined as outliers Outliers included individuals for which standardized first or second principal component values were further than 5 s.d from the mean or had a median NPX or IQR of NPX greater than 5 s.d Individual datapoints with sample or assay warnings or those belonging to 70 plates that failed to satisfy QC criteria were set to missing not using any primary care data made available solely for COVID research) cancer and death registries and from UKB health questionnaires We excluded prevalent cases (first occurrence before or up to the baseline assessment visit) or incident cases recorded within the first 6 months of follow-up We note that we did not exclude ‘controls’ (that is individuals that did not develop the disease under study) with other prevalent conditions This represents the scenario that is closest to the clinical reality were multimorbidity is increasingly common and the most useful prediction models will be those that can discriminate the outcome of interest in the presence of other underlying diseases or conditions We performed a sensitivity analysis for 19 of the 25 diseases for which incident cases among consortium-selected participants were included there were at least 60 incident cases within the random subset of UKB-PPP enabling demonstrating good agreement in predictive performance from the main analyses and by excluding consortium-selected incident cases from the test set (Pearson r = 0.97) This showed no strong bias introduced from inclusion of participants who were selected based on specific characteristics or genetic risk of specific diseases including additional information on age and sex without replacement) was used to grow the number of trees in each forest we tested all optimized models in individuals from the validation set that had no missing values (for the proteins from the final model) to assess the quality of the imputation procedure We observed good agreement between performance metrics derived in the test set which included a small proportion of imputed protein values and those derived from individuals with no missing data (Pearson r = 0.94) We further imputed missing values for clinical assays (UKB Category 17518) and nine blood cell traits (leukocyte hemoglobin concentration and hematocrit percentage) in the individuals who also had clinical assays available (N = 47,901) We adapted a three-step machine learning framework including (1) feature selection (2) hyperparameter tuning and optimization and (3) validation Individuals were grouped as follows: 50% for feature selection for diseases with more than 800 cases; otherwise into a 70% feature selection and model optimization set and 30% for validation Validation sets included nonoverlapping individuals completely blinded to previous model development stages We used regularized Cox regression to derive a ‘benchmark’ clinical model by fivefold crossvalidation in the optimization or training set using the features described above Validation was performed in the held-out test set where we computed the C-index over 1,000 bootstrap samples Selection scores were computed as the absolute sum of weights from the model with the optimal lambda from each of the 200 iterations and were used to identify the top 20 proteins or clinical assays The top 20 proteins or clinical assays with the highest feature selection scores were taken forward for optimization of a regularized Cox model including the clinical risk factors by fivefold crossvalidation (optimization set or feature selection set for diseases with fewer than 800 cases) To further identify sparser predictor sets the top five and top ten features were identified as those with the highest product of the weights from optimized models (clinical risk factors + top 20 features) and feature selection scores Optimization of a clinical model plus five or ten features was similarly done by regularized Cox regression by fivefold crossvalidation (optimization set) Performance was tested in the validation set by computing the C-index over 1,000 bootstrap samples models based on the top five proteins alone (without any clinical risk factors) were further trained and tested in the same manner we kept the best performing protein signature and clinical assay signature as the one that had the highest C-index in the validation set Significant improvements between models were considered as those for which the 95% CI of the differences in the bootstrap C-index distributions did not include zero We calculated the following screening metrics: DRs and LRs in the validation set at FPR ranging from 5% to 40% The FPR was calculated as FPR = false positives (FP)/(true negatives (TN) + FP); and detection rates were calculated as DR = true positives (TP)/(false negatives (FN) + TP) All analyses were performed in R software v.4.1.1 We calculated category-free net reclassification improvements from addition of proteins to the clinical models using a 0.15 cut-off in risk difference to provide more conservative estimates We further calculated integrated discrimination improvements from addition of proteins to the clinical models using the R package survIDINRI The performance of the clinical and clinical + protein models was tested by stratifying the validation set by sex (men versus women) and age at onset (<65 years versus ≥65 years at disease onset) We retained only 121 and 134 diseases for which sex-stratified and age-stratified validation sets had at least 20 incident disease cases We computed the C-index over 1,000 bootstrap samples of the stratified validation sets Significant differences between age- or sex-stratified performance were considered as those for which the 95% CI of the differences in the bootstrap C-index distributions did not include zero significant differences between stratified performance of protein-informed models and clinical models were considered as those for which the 95% CI of the differences in the bootstrap C-index distributions did not include zero The performance of the clinical and clinical + protein models trained to predict the risk of 10-year incidence was tested for 5-year incidence (same validation sets) This was tested for diseases for which 10-year incidence prediction (C-index) was significantly improved or improved by more than 4% and had at least 20 incident cases within 5 years of follow-up in the validation set (54 diseases) We further repeated the entire procedure (that is model optimization and testing) on the first subset of Olink Explore 1536 proteins using the exact same data splits for comparability (that is the same individuals used in this analysis as those used in training/testing for the main analyses done on 1536 + Expansion proteins) this method fits a linear mixed model and estimates the proportion of variance explained attributed to each of the explanatory variables We used this framework to identify the main correlates for each of the five proteins We compared the proportion of variance explained by each of the variables for these five proteins with the average proportion of variance explained across all other proteins we split Olink IDs corresponding to several proteins (protein complexes) into their components based on ENSEMBL gene IDs PNLIPRP2) assayed by Olink were not found on HPA To determine whether proteins that HPA reports as tissue specific were enriched among selected protein candidates we performed a two-sided Fisher’s exact test for each tissue-specificity with the number of selected/nonselected and specific/nonspecific proteins We defined tissue specific as ‘enhanced,’ or ‘enriched’ according to HPA classification Some proteins were hence ‘specific’ to several tissues We used all protein coding genes covered by the Olink Explore platform as a background and tested for enrichment of (1) selected protein candidates per disease and (2) proteins selected for at least three diseases We used the Benjamini–Hochberg (BH) procedure to account for multiple testing Differential gene expression between BM cell types and healthy versus malignant states was investigated by comparing the mean expression levels of the gene of interest per patient or control using Wilcoxon rank sum test BH was used to adjust for multiple comparisons The study was approved by the Norfolk Research Ethics Committee (reference no hospitalization data and cancer registry data was obtained using National Health Service (NHS) numbers through linkage with the NHS digital database EHRs were coded by trained nosologists according to the International Statistical Classification of Diseases and Related Health Problems Participants were identified as having experienced an event if the corresponding ICD-10 code was registered on the death certificate (as the underlying cause of death or as a contributing factor) cancer registry or as the cause of hospitalization Given that the long-term follow-up of EPIC-Norfolk included the ICD-9 and ICD-10 coding system using the Olink Explore 1536 and Olink Explore Expansion panels targeting 2,923 unique proteins by 2,941 assays Participants were excluded due to failed proteomic QC Because family history of the disease was not available in EPIC-Norfolk we trained models in UKB without this variable We used the weights from the models trained in UKB to evaluate their performance in EPIC-Norfolk While the models developed in UKB were trained for prediction of 10-year incidence we tested predictive performance for 10-year and 20-year incidence in EPIC-Norfolk given the low sample size and design of this study We excluded prevalent cases (for the disease being tested) and incident cases occurring within the first 6 months of follow-up significant improvements between models were considered as those for which the 95% CI of the differences in the bootstrap C-index distributions did not include zero Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Associated code and scripts for the analysis can be found in the following GitHub repository: https://github.com/comp-med/Sparse-proteomic-prediction-of-common-and-rare-diseases.git Targeted screening in the UK: a narrow concept with broad application 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Quantifying intervals to diagnosis in myeloma: a systematic review and meta-analysis Diagnostic delay in IPF impacts progression-free survival Mapping opportunities for the earlier diagnosis of psoriasis in primary care settings in the UK: results from two matched case-control studies Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study Plasma protein patterns as comprehensive indicators of health The personal and clinical utility of polygenic risk scores Polygenic Risk Score Task Force of the International Common Disease Alliance Responsible use of polygenic risk scores in the clinic: potential benefits Proteomic signatures for identification of impaired glucose tolerance Gadd, D. 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J. et al. UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits. Preprint at medRxiv https://doi.org/10.1101/2022.06.16.22276246 (2022) Plasma proteome profiling to assess human health and disease Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population Plasma proteomic associations with genetics and health in the UK Biobank Genetics of 35 blood and urine biomarkers in the UK Biobank The polygenic and monogenic basis of blood traits and diseases Proximity extension assay in combination with next-generation sequencing for high-throughput proteome-wide analysis Next generation plasma proteome profiling to monitor health and disease MissForest—non-parametric missing value imputation for mixed-type data ROSE: a package for binary imbalanced learning variancePartition: interpreting drivers of variation in complex gene expression studies Comorbidity measures for use with administrative data gprofiler2–an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler EPIC-Norfolk: study design and characteristics of the cohort European prospective investigation of cancer Download references Proteomics measurements in EPIC-Norfolk were supported by an MRC Rapid Call (MC_PC_21036 was supported by a 4-year Wellcome Trust PhD Studentship and the Cambridge Trust is supported by Health Data Research UK and the National Institute for Health Research University College London Hospitals Biomedical Research Centre Werner Römisch-Margl and Gabi Kastenmüller for their support designing and implementing the associated webserver These authors contributed equally: Julia Carrasco-Zanini Precision Healthcare University Research Institute Berlin Institute of Health at Charité-Universitätsmedizin Berlin University College London Hospitals NHS Trust Heidelberg Institute for Stem Cell Technology and Experimental Medicine Deutsches Krebsforschungszentrum (DKFZ) and DKFZ–ZMBH Alliance Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association British Heart Foundation Data Science Centre conceptualized the project and designed the analysis performed QC and prepared proteomic data and disease definition in UKB developed the phenotyping algorithm to derive refined disease definitions is Principal Investigator of the EPIC-Norfolk cohort performed scRNA-seq experiments and analyses All authors contributed to the interpretation of the results and critically reviewed the manuscript are all employees of and/or shareholders of GSK The remaining authors declare no competing interests reviewer(s) for their contribution to the peer review of this work in collaboration with the Nature Medicine team Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations a, Study design used for 193 diseases for which only participants from the randomly selected subset were included in the analysis. b, Study design used for 25 less common diseases were incident cases within 10 years of follow-up for the specific disease under study were included in the analysis. Created with BioRender.com Predictive performance (C-index) of protein-based models across 67 diseases for which these outperformed clinical models was not correlated with the number of incident cases within 10 years of follow-up Predictive performance (C-index) of the clinical models was not correlated with the number of incident cases within 10 years of follow-up Improvement in predictive performance (delta C-index) of protein-based models over clinical models appeared to be the largest for diseases less frequent among the UKB population We present the mean C-index with a 95% confidence interval shown by the error bars Improvement in predictive performance (delta C-index) of protein-based models was not correlated with baseline prediction of the clinical models UMAP representation of scRNA-seq data of 11 BM samples from MM patients at initial diagnosis and 3 healthy controls UMAP from (A) split by clinical state (healthy Cell density and distribution is illustrated by color BM UMAP from (A) highlighting the plasma cell state healthy (green) malignant (red) and unclear (yellow) based on copy number aberrations detected by inferCNV UMAP with highlighted gene expression of predictor proteins across all celltypes in the BM Mean gene expression levels of predictor proteins within the BM split by cell type Data are presented as median values; box edges are 1st and 3rd quartiles; and whiskers represent 1.5× interquartile range (N = 3 - 14) Mean gene expression levels of predictor proteins within the BM split by cell type and clinical state (healthy Box plots illustrating mean gene expression of predictor proteins within healthy versus malignant plasma cells of MM patients at initial diagnosis as characterized by inferCNV Data are presented as median values; box edges are 1st and 3rd quartiles; and whiskers represent 1.5× interquartile range (N healthy = 8 Comparison of C-index achieved by UKB-trained models in the UKB validation set and in EPIC-Norfolk (for 10-year incidence) Comparison of the improvement in C-index of the protein-based models over the clinical model in UKB and in EPIC-Norfolk (for 10-year incidence) Replication of the improvement provided by protein signatures identified in UKB Predictive performance for 10- and 20-year incidence are shown We present the median C-index with a 95% confidence interval N: Number of incident disease cases Number of individuals diseases for which a protein was selected as a predictor across the 67 diseases These were diseases for which the C-index was significantly improved or improved by more than 0.4 over the clinical model Average contribution of proteins across diseases Average weights (normalised to the top predictor) from the optimised prediction models for each protein (across diseases for which it was selected as a predictor) Proportion of variance by age, sex, body mass index (BMI), smoking status and a comorbidity score (see Methods) in a joint model This is compared the average variance explained by each of these characteristics in plasma levels of all other proteins Comparison of the improvement in predictive performance over clinical models (delta C-index) provided by PGS and 5–20 proteins Only 7 diseases for which the PGS provided a significant improvement in performance are shown Supplementary Tables 1–22 and table headers 1–22 Download citation DOI: https://doi.org/10.1038/s41591-024-03142-z Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Bevin O'Connor Gordon and David Langenberg Martinez and David Farrington in the Harris County Emergency Services District No Danica joined Community Impact as a reporter in 2016 development and other issues affecting the Cy-Fair community Her experience prior to CI includes studying at the Washington Journalism Center in Washington serving as editor-in-chief of Union University's student magazine and online newspaper and reporting for other publications in Arkansas and Tennessee She always has her nails painted and will never say no to ice cream Those left to honor Ralph's memory are his son Susan (and Michael D.) Maxwell of Newton and JoAnn (Marc) Wasserman of Pennsylvania; his 4 grandchildren Jeffrey (and Lariza) Rethmeier and James (and Amy) Rethmeier; 9 great-grandhcildren He was preceded in death by his parents; wife Helen in 2006; his son Ralph Frederick Rethmeier; and 5 brothers Ralph was a farmer and also did maintenance work for the Johnny and Kaye's Hiatt House in Des Moines for many years He was a member of the Zoar Church and enjoyed fishing Memorials to the Zoar Church or the Willowbrook Adult Day Care may be left at the Wallace Family Funeral Home or the church the afternoon of the service Wallace Family Funeral Home and Crematory1115 E N. | Newton, IA 50208-2539 | Tel: 1-641-787-9911 | Fax: 1-641-787-9208 Please enable JS and disable any ad blocker Joined high-Class A team Tuesday after promotion from low-A Fort Myers CEDAR RAPIDS — The Minnesota Twins announced Tuesday afternoon that pitcher Ty Langenberg has been been promoted to the high-Class A Cedar Rapids Kernels The Urbandale native was an 11th-round draft pick of the Twins last summer out of the University of Iowa He made 39 appearances for the Hawkeyes in three seasons the right-hander had a 3-3 record and 3.38 earned run average in nine starts He was 3-0 in his last five starts for the Mighty Mussels allowing just six earned runs over 32 2/3 innings with a six-game series at Lansing beginning Tuesday night They return home next week for six games against Peoria Langenberg is believed to be the first former U of I player to play professional baseball in Cedar Rapids since 1982 when outfielder Jeff Jones and infielder Tony Burley played for the Cedar Rapids Reds Burg Simpson trial attorney Matthew Langenberg is a personal injury lawyer who represents those who have been severely injured through the fault of another He currently specializes in serious and complex cases and has almost a decade of experience as a litigator in personal injury Langenberg deftly manages cases from inception to trial and excels when negotiating or litigating on his client’s behalf Langenberg has established himself as a formidable legal advocate who will fight to obtain the best possible outcome Completing his undergraduate degree at the University of Missouri in 2006 he earned his law degree from Tulane University Law School in 2009 he also obtained a Master of Law Degree (LLM) in Energy & Environment Langenberg litigated in a wide variety of areas including personal injury and handled cases involving insurance issues He is a current member of the Colorado Bar Association Please fill out the case evaluation form below and Submit Now, or call Burg Simpson directly at 888-895-2080 today Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Δdocument.getElementById( "ak_js_2" ).setAttribute( "value" The firm is responsible for the content on this website This information is not to be interpreted as providing legal services Anyone considering a lawyer should independently investigate the lawyer's credentials and ability and not rely upon advertisements or self-proclaimed expertise All content Copyright 2025 © Burg Simpson Eldredge Hersh & Jardine Northeast/North Central Nebraska’s most trusted Burial will be in Pleasantview Cemetery in Winside NORFOLK — A celebration of life for Robert J at First Baptist Church in Norfolk with the Rev Inurnment will be at the Prospect Hill Cemetery in Norfolk Stonacek Funeral Chapel is in charge of the arrangements are pending at Stonacek Funeral Chapel in Norfolk Home for Funerals in Norfolk is in charge of arrangements Burial will follow at New Lutheran Cemetery in Norfolk at Trinity Lutheran Church in Madison with the Rev Burial will be at Crown Hill Cemetery in Madison at the United Methodist Church in Meadow Grove at Sacred Heart Catholic Church-Olean with burial at Ss Peter and Paul Catholic Cemetery in Howells of Howells are pending at Minnick Funeral Home in West Point of Norfolk are pending at Stonacek Funeral Chapel in Norfolk WeatherThreat.com Closings Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Account processing issue - the email address may already exist Invalid password or account does not exist Submitting this form below will send a message to your email with a link to change your password An email message containing instructions on how to reset your password has been sent to the email address listed on your account Blackned wants to drive forward the digitalization of armed forces with its Tactical Core, as CEO Joel Langenberg explains. A conversation about the associated opportunities and challenges, digitalization strategies of the German Armed Forces and what role his company wants to play in the Austrian market Mr Langenberg, many armed forces are currently facing the challenge of having to digitize their often outdated structures. How big is this challenge really? This challenge is indeed enormous. Ongoing initiatives by NATO and the EU confirm a growing awareness of the need to digitalize armed forces in order to ensure and increase information superiority and defence capability in a sustainable manner and with a view to the current global challenges Digitalization or digital transformation certainly means the introduction of new disruptive technologies that connect the chain of effects of weapon systems in the first place automate them more and thus make them more efficient and effective it is not just the introduction of new technologies that enables digital transformation but also the integration of existing technologies into the target image of a networked network of effects So we are talking about a very comprehensive approach that is needed for digitalization because in addition to the technological factor there are also other factors that need to be considered in order to shape digitalization holistically and comprehensively traditional thought patterns that have been valid for a long time and The result is a complexity that presents the armed forces with the major challenge of taking many factors into account simultaneously in order to digitalize successfully your company promises a “framework for a future-proof and open digital platform for a wide range of digitalization projects” this means that our software solution answers the pressing questions of secure mobile and stable networking of various communication and information systems and technologies on the battlefield from the dismounted soldier to the command post Our vendor-neutral and therefore open approach makes it possible to provide data from these different systems and platforms to all participants in the networked group on the battlefield in order to make decisions the various systems can be systems that have already been procured and are in use while on the other hand our Tactical Core enables the integration of new innovative technologies that meet the respective requirements so that armed forces are fit for the future What are the unique selling points of Tactical Core Tactical Core offers armed forces a reliable and efficient data and communication infrastructure Regardless of the transmission medium or application cross-sectionally usable communication network and a uniform distributed database – a shared information space – are made available to ensure efficient harmonization and synchronization for example via narrowband communication media All of this is embedded in an overarching security architecture the German Federal Office for Information Security (BSI) has certified the data transmission of Tactical Core with the “NATO Restricted” security level So what opportunities are associated with it Tactical Core is the enabler for a manufacturer-independent digitalization of armed forces controllable migration from and with existing legacy systems to a future-proof thereby creating interoperability between allied armed forces on the one hand and achieving information superiority and decision-making advantages over opposing forces on the other Blackned has only been around for a few years and is a comparatively small player on the market Why did the Bundeswehr nevertheless choose your company for its “Digitalization of Land-Based Operations” (D-LBO) project The founders of Blackned are former officers of the German Armed Forces who experienced first-hand the challenges of communications technology at the time This experience was the starting point for their motivation to significantly improve the communication capabilities of the armed forces Blackned was able to develop a modular and highly mobile communications concept at an early stage which was successfully implemented in the “Subscriber network Particularly noteworthy was the development of a highly mobile communication element in the form of a backpack which laid the foundation for Tactical Core and thus the technical basis for D-LBO it is not a matter of course that the contract was awarded to your comparatively small company our close and continuous cooperation with the Bundeswehr has enabled us to develop a practical and efficient solution in studies and projects Many of our employees have a background in the armed forces themselves and are familiar with the specific requirements and challenges This shared experience and our deep understanding of the Bundeswehr’s needs meant that we spoke a common language from the outset and delivered tailored results the Bundeswehr therefore decided to commission us with the series production of the Tactical Core This decision reflects the Bundeswehr’s trust in our expertise which we have successfully demonstrated despite our relatively young company history Europas Luftstreitkräfte rüsten massiv auf Does this mean that cooperation agreements and contracts have already been concluded we have already concluded most of the necessary contracts for system integration and the last contract negotiations are in the final phase This ensures that the systems are integrated in a targeted manner and in line with the Bundeswehr’s strategic objectives The D-LBO project is therefore well on the way to implementing the modernization and digitalization of the Bundeswehr efficiently and on schedule is your company in a position to tackle these challenges alone Or do you work together with partners to implement them No company can manage such a complex project as D-LBO on its own That is why Blackned works with many partners who take on certain tasks in the practical implementation of the project or simply provide support The pure software development of the system core and the adaptation to the numerous platforms of the public client is essentially carried out by Blackned itself Which partners does Blackned have on board the industry has set up several joint ventures take care of the realization of the IT setup or the major task of vehicle integration For the realization of further projects within the overall framework of D-LBO there are further close cooperations with companies with which Blackned has a relationship as a subcontractor or general contractor and Blackned will only be able to expand into the international market within a country-specific ecosystem We aim to cooperate with the defense industry in new markets in order to integrate our software solutions into their military systems we have licensed rebuildable documents to system integrators The system integrators use these to build communication systems for the national armed forces in the respective country I would like to emphasize that we can implement our software with country-specific encryption for each of these countries Our software has interfaces to which the national crypto industry can dock in order to develop this country-specific encryption This cooperation has already led to successful operational tests and Tactical Core is currently in the US Army’s testing and approval phase (ATO process) At the moment, your company is also increasingly looking to Austria, as the Austrian Armed Forces are also on the verge of a digitalization offensive, as Lieutenant General Bruno Hofbauer, Head of Planning, tells us in an interview(-> “We’re really stepping up the pace!”) we want to play a central role in this initiative as we are convinced of the efficiency of our solutions Blackned strives to work closely with Austrian industry to make the most modern and efficient digitalization technologies available to the Austrian Armed Forces Our aim is to implement these solutions quickly we attach great importance to comprehensively understanding the specific requirements of the Austrian Armed Forces and offering solutions tailored to them we bring over 15 years of experience to the partnership in order to provide the armed forces with a tailor-made solution that has proven itself in practice You said that Blackned aims to work closely with the local industry That is a very important aspect of our approach Our goal is to create added value for the Austrian defense industry through system integration and local production We see the greatest potential for successful and rapid implementation of the digitalization offensive in this combination what are the challenges facing the Austrian Armed Forces The armed forces are facing several complex challenges particularly in the context of digitalization One central challenge is the integration of the established infrastructure must not only be taken into account in a digitalization strategy but also protected and optimally integrated the armed forces have a wide variety of systems and technologies The armed forces actually use a wide range of manufacturers weapon systems and communication technologies all of which need to be harmonized with one another The challenge here is to develop solutions that enable the seamless integration of these different systems A practical example of this is the connection of older analog on-board communication systems to modern digital radio technologies or even cellular communication structures such as 4G and 5G This integration requires customized approaches to ensure that existing technologies can also be used efficiently in a digital environment the consolidation of data from various sources such as radar systems drones and other surveillance systems is an essential aspect of digital transformation Effective networking and analysis of this data is crucial to improving the Armed Forces’ ability to communicate and make decisions Targeted digitalization and integration can significantly increase the operational capability of the armed forces and prepare them for the requirements of the future “It is not only the introduction of new technologies that enables digital transformation but also the integration of existing technologies into the target image of a networked network of effects.” Blackned-CEO Joel Langenberg Do you see any other areas of application for Tactical Core Tactical Core also offers significant advantages for civil security far beyond military use One important capability is the provision of a highly mobile and autonomous 5G/4G network This technology can be flexibly deployed in various formats such as in vehicles or even in backpacks … … which would make you highly mobile the scenario in a backpack really does open up completely new possibilities in disaster control where the regular communication infrastructure is often destroyed or inaccessible Tactical Core can enable self-sufficient 5G communication in the vicinity of the disaster area for four to six hours This allows emergency personnel to communicate efficiently and securely via smartphones as soon as they arrive on site – via voice This capability can make a decisive contribution to significantly improving the coordination and effectiveness of rescue and relief measures in disaster areas we also see potential areas of application in supporting major events where temporary and high-performance communication networks are required as well as in securing critical infrastructures how do you see the further development of your company and the entire subject area Will we still be talking about digitalization in ten years’ time or will most of the projects already be completed by then Digitalization in the defence sector is still in its infancy There is currently talk of transporting critical data and solutions are being developed for this distributed databases and cloud solutions to make information available in a normalized form for a variety of applications we are still in the early stages in this area in particular and are not yet able to gain a complete overview of its use and development The connection between sensor and effector will also be a key task in the near future AI is currently integrated to a certain extent in subsystems the cross-system use of AI is not yet available The multitude of tasks and intended applications will certainly keep Blackned busy and growing for many years to come Here for more news about Blackned Militär Aktuell berichtet Online und Print über Militär- und Sicherheitsthemen das Bundesheer hat die Argonauten-Saga mit 25 Luftfahrzeugen neu interpretiert das Red Bull Blanix-Team und das Czech Flying Bulls Aerobatics Team Die "Airpower 2024" geizte nicht mit Highlights wie auch dieser eindrucksvolle Bildband zeigt Auf 70 Seiten holen wir im Format 210x210 Millimeter den europäischen Flugshow-Höhepunkt 2024 noch einmal in Erinnerung Jetzt vorbestellen! Wir informieren in unserem Newsletter alle zwei Wochen über aktuelle Entwicklungen aus den Bereichen Bundesheer Zudem verlosen wir monatlich unter all unseren Feldpost-Abonnenten attraktive Preise a physicist and past president of the American Association for the Advancement of Science who led the University System of Maryland to national renown As a researcher at the University of Pennsylvania Langenberg was part of a team that worked to develop the international measure of the volt a role he was initially reluctant to take on but grew to love Langenberg thrived in various leadership roles at the University of Pennsylvania as deputy director of the National Science Foundation and as chancellor of both the University of Illinois at Chicago and the University System of Maryland “Don was an all-around incredible statesman for science,” said AAAS senior adviser Shirley Malcom who collaborated with Langenberg at NSF and AAAS Friends and colleagues from across the country traveled to Baltimore for a March 2 memorial service for Langenberg at the University of Maryland Medical School “He was a renaissance man in that he just absorbed information,” said Patricia Langenberg professor emeritus of epidemiology and public health at the University of Maryland Medical School and Don Langenberg’s wife of 65 years Whenever our children had any questions about anything — or if I had a question — the first place we’d go was Don his first language was American Sign Language Worried that neighborhood boys were teaching their son improper speech Langenberg’s parents sent him at age 3 to live with and learn English from his grandparents in Iowa He returned to North Dakota after completing second grade and graduated from Devils Lake High School in 1949 “He was giving a book review in the student union a day or two after the first date and we were engaged by spring break and married a week after graduation.” After earning his bachelor’s degree in physics from Iowa State in 1953 his master’s from the University of California Langenberg completed two postdoctoral fellowships and joined the University of Pennsylvania as an assistant professor of physics in 1960 his research team became known for being the first to precisely measure the ratio of elementary charge to the Planck constant a formula used in defining new international standards of voltage condensed matter physics was kind of a stepchild,” said Alan Heeger a Nobel laureate and close friend of Langenberg’s “The people in particle physics and nuclear physics were considered the elite and condensed matter physics was sort of considered dirty physics though initially disinclined to give up research Langenberg accepted an offer to join the University of Pennsylvania administration directing the Laboratory for Research and the Structure of Matter He then served as the university’s vice provost for graduate studies and research from 1974 through 1979 when President Jimmy Carter appointed him deputy director of NSF Langenberg went on to serve as chancellor of the University of Illinois at Chicago from 1983 to 1990 and chancellor of the University System of Maryland from 1990 to 2002 The system’s budget nearly doubled during those 12 years reaching $2.7 billion by the end of Langenberg’s tenure With the new leadership and increased spending came unprecedented prestige for the state’s higher education institutions “The 11-campus system appears well on its way toward eminence,” The Baltimore Sun reported in 2002 there’s a national buzz about the Maryland system particularly its professional schools in Baltimore its burgeoning online University College and its brash young UMBC Among the initiatives that Langenberg spearheaded was the Maryland K-16 Partnership secretary of the Maryland Higher Education Commission The program works to create seamless transitions as students progress from pre-kindergarten through college “Don was a visionary in seeing the strong relationship between pre-kindergarten through high school and higher education,” Grasmick said “He spent considerable time focusing on the importance of pre-K to high school and not seeing higher education as a singular entity.” During his career in higher education administration Langenberg stayed active in the scientific community serving as president of AAAS in 1991 and president of the American Physical Society in 1993 He also chaired the National Council on Science and Technology in Education at AAAS from 1996 to 2002 In a powerful President’s Address at the 1991 AAAS Annual Meeting, later published in the journal Science Langenberg spoke about the civic duty of scientists in society elected officials and the citizens they influence assess the effectiveness of universities and other publicly funded institutions in the absence of scientific knowledge leading to misguided political and economic decisions “We should not concede center stage in the assessment debate to our political leaders,” he said They should be there not because the outcome of the debate might affect the narrow self-interests of the scientific and educational communities but because it will surely affect the greater and more important interests of our society as a whole.” should be seen as synonymous with advancing society “Science and the technology it spawns are important for what they contribute to enhancing the quality of human life,” he said “As I look around at the means our science and engineering community has for bringing its ideas and talents to bear on the great public issues of our time I see nothing remotely as well suited to this purpose as the AAAS.” Our ability to provide a voice for scientists and engineers and to advance science depends on the support from individuals like you Give together we can be a united voice for scientific progress.  Join MEDIA CONTACT: Jonathan Saxon, jsaxon@bowiestate.edu a second-year master’s student in the public administration and policy program will represent Bowie State University in this year’s cohort for the Langenberg Legacy Fellows program which supports students to make a difference on campus through a public service project selects one student from each University System of Maryland (USM) member school who seeks to improve the world through local Program fellows propose a public service project that addresses an on-campus issue and are awarded a $1,000 stipend to fund the project plus another $500 after it’s completed Fellows are also invited to participate in USM sponsored networking events and professional development opportunities “There is a lot of opportunity for public service and engagement on the campus so I’m excited to be able to do this small part to contribute to our wellbeing.” Johnson’s project focuses on enhancing access to products that support sexual and reproductive health She is working to get vending machines placed around Bowie State’s campus that distributes contraceptives Johnson also wants to create a connection between Bowie State and an outside medical clinic that specializes in reproductive and sexual health services She plans to have the machines in place by the fall semester “I would like us to get a really comprehensive plan for services that are accessible and make sure those resources are available to students when they come to campus,” said Johnson Johnson’s interest in reproductive health was sparked by national trends towards anti-abortion legislation triggered by the U.S “A lot of people take for granted the strides that have been made to get us to a point where people are able to make their own decisions about their reproductive health It’s important to have a voice and put action behind those words so we can maintain autonomy.” 301-860-4000 or 1-877-77-BOWIE A University System of Maryland Member Institution Contact webmaster@bowiestate.edu © Leeham News: China isn’t getting into the commercial aviation industry to let Airbus and Boeing supply three quarters of the market The long-term outlook for the Big Two aircraft producers may be considerably more bearish than many think He made the following comments when asked about the new Boeing (BA) projections for the aircraft market in China “COMAC wants to hit 150 (deliveries) in the next five years That means that one-fourth of that China demand goes to COMAC,” said Brian Langenberg principal and industrial strategist of Langenberg and Co “If you believe that China got into the commercial aviation industry to let Boeing and Airbus make three-fourths of their narrow bodies aircraft,” he says people underestimate the determination of the Chinese government The C919 is COMAC’s latest narrow-body jet which began commercial service at China Eastern Airlines (CEA) in 2023 and China Southern as COMAC slowly ramps up production COMAC has more than 1,000 orders for the type with the vast majority coming from airlines and lessors in China although AerCap of Ireland has orders for 20 LNA believes the learning curve will take longer than production managers suggest International certification by European and US regulators is also important to China and mandatory for export sales China still needs Boeing to fill demand To read the rest of the article Login or Subscribe today.  Category: Airbus, Comac, Premium  Tags: , , , Click to subscribe to this blog and receive notifications of new posts by email Copyright © 2025 · All Rights Reserved · Leeham News and Analysis When Lone Tree native Doug Langenberg reached the end of his high school career he was faced with the question that many graduates struggle with — what comes next?  Rather than taking the traditional route of college to career Langenberg chose a path that he said worked better for his goals and interests.  and later attended Iowa State University in the Navy ROTC program Langenberg became a commissioned officer in 1997 I just wasn't ready for college and I needed more time to determine what I really wanted to do The Navy offered an education and the direction that I needed at the time,” Langenberg said in an email to the Press-Citizen I believe it offered the opportunity to mature and focus on what I wanted to do long-term with my professional life.” After years of experience and learning from the U.S Langenberg became captain of the USS John P Langenberg said he has spent most of his career on a team that is part of an air wing on an aircraft carrier Langenberg noted how unique this leadership opportunity is for him.  and the young people that raise their hand and swear an oath to protect the Constitution will always have a special place in my heart,” Langenberg said “I have the pleasure to work with a bunch of superheroes and I pray we never lose sight of the fact that we need to continue to cultivate the next generation of people who will take this oath.” Langenberg said he sees his Iowa roots come up in unexpected ways Navy has allowed him to meet a variety of people from all walks of life He said he believes unique backgrounds are able to give individuals unique strengths.  Langenberg noted this when a Navy chaplain performed at his wedding ceremony 20 years ago the chaplain approached him and said that the Iowans he met were “salt of the earth” type of people.  “I see those words as a perfect fit. Iowans are wholesome friendly and hard-working.  They represent people of good character and are friendly and inviting. I try to remind myself of these traits when I interact with the people I serve with,” he said Langenberg said the hardest part of his job are the long stretches of time he spends away from his family. He estimated that he sees his parents and brother's family once a year Langenberg was also sure to express gratitude to his family calling them part of the reason he is able to continue serving in the Navy who is originally from Waterloo, has spent most of the last 25 years away from her family as well.  Langenberg said he has had to miss many important milestones which has been difficult for him to grapple with Langenberg said he looks to make the most out of the time he has with his loved ones.  “There is a long list of people I draw inspiration from. At the top of the list is my wife son and daughter. They have sacrificed a great deal for my career as they moved from one duty station to the next changing schools and making new friends,” he said “Their strength and resiliency inspires me and they are always there to lift me up when I'm worn down.”   Langenberg said the rewards and opportunities the Navy has offered him have been worth the lifetime of service Due to the collaborative nature of working with a team he has been able to learn about himself and others.  “The greatest reward has been seeing others succeed both as individuals as well as a team.” Langenberg said “There is no greater reward than seeing the culmination of a team's efforts in successfully completing a tough mission.” Having recently been named captain of the USS John P Langenberg is choosing to live in the present.  “I have always believed to take it a step at a time I always feel like if I'm thinking too far ahead that I would lose focus on what is important now,” he said “I don't yet know what the future holds but for now I have plenty to focus on.” with several operators offering sterling itineraries guides and service to the travel agency community how do you decide which one works best for you At a seminar held 21OCT at Humber College’s campus in western Toronto some 40 travel advisors convened to learn more about Collette and why the company has survived – and thrived – for more than 100 years Here’s a snapshot of what the agents learned: Collette has something for every client in the market for a guided tour Not only to every continent – including Antarctica – but in five different “styles” The styles comprise: Classic (max 44 pax); Small group (max 24); Spotlight (single hotel stay with “hub and spoke” day tours); Cruising; and Faith-based 2) The company is careful to spell out the fitness level required for every itinerary the average Collette client is 63 years old and main nationalities are US there’s a comma in your cheque.” And Collette pays commission on not just the package but the flights (And the flights are flexible in case your clients wish to extend their vacation pre- or post-tour.) Which is to say that a Collette tour is not the cheapest thing on the market Kaczuga gave a great tip: spell out all of the inclusions in detail before mentioning price 4) The company has recently diversified its tour inclusions to feature more memorable accommodation such as castles in Europe glamping in Morocco and a stay in a glass igloo in Finland And there are more dinners in local restos (as opposed to at the host hotel) and meals hosted in private homes 5) The three top-selling tours so far for 2025 are all in Africa 6) Collette’s travel protection will cover cancellation for any reason whatsoever 7) And when clients live within a 100 km radius of Pearson Airport airport transfers by private chauffeur service are included – an average value of $200 and a great way to “set the tone” for a memorable vacation the company has a 76 page Travel Advisor Resource Guide for 2024-25 referring to the continuous tweaking of itineraries and addition of new programs if the evening’s appreciative audience is typical of Collette’s supporters Find out more at collette.com and at their travel advisor portal gocollette.com/travel-advisors A contributor to Open Jaw since 2006 - and known to all in the business - Martha has worked in the travel industry all of her career and covers events personalities and issues in the travel world You must be logged in to post a comment ETOBICOKE — Collette’s brand new Encompass campaign enjoyed a strong debut at a cross-Canada roadshow this month The tour operator introduced Encompass to 1,000+ travel advisors in 12 cities The schedule included a get-together in Etobicoke earlier this week Agents heard all about the four Encompass tools They also joined Collette in celebrating the company’s 107th season of travel Collette’s self-service tools — MyCollette and the Travel Advisor Portal — are designed to enhance efficiency while their learning tools — Collette University and the Travel Advisor Resource Guide — focus on building confidence in selling told Travelweek: “We have here an enhanced booking platform that we’ve been working on for about two years It’s not only a new online reservation booking engine for agents it’s also going to be an online educational platform.” Langenberg added: “Collette University’s modules are just a click away and they’re seven minutes in length It’s very easy for agents to get their Collette certificate They can even do it on their coffee break.” Langenberg said travel advisors also now have the ability to order brochures for their clients directly email them their Collette invoices and comparison shop all through the system The events included networking over cocktails and canapés or a leisurely breakfast a comprehensive overview of the new tools by a Collette representative and opportunities to work one-on-one with Collette team members each event launched the beginning of Collette’s 107th year of travel and the 15th anniversary of its Small Group Explorations product line “Events like these allow us to get direct feedback and have great conversations,” said Ron Lonsdale we’re able to develop and enhance tools that truly help them work more efficiently and sell with confidence.” The Collette team is working on more courses and learning paths for Collette University and enhanced resources in the Travel Advisor Portal Agents can sign up for an account in Collette’s Travel Advisor Portal at gocollette.com/travel-advisors Exclusive access to Canadian travel industry news Subscribe Now You may not be able to find the page you were after because of: You might find one of the following links useful: the Global Sector Manager for Building Materials at Malvern Panalytical talks to AzoBuild about sustainable challenges in the cement industry AZoBuild had the pleasure of speaking with Dr Silke Langenberg from ETH Zurich about her impressive career and research Director at Suscons and Founder of Street2Meet about initiatives he is overseeing that look to provide sturdier and safer emergency shelter to those who need it Seismic modeling powered by supercomputing is reshaping infrastructure planning more resilient designs for earthquake-prone regions Cutting-edge technologies in construction are enhancing safety and efficiency with innovations like BIM and digital twins leading the way for future projects The aerogel insulation market is experiencing significant growth projected to reach USD 3.8 billion by 2030 driven by demand for energy-efficient materials Addressing workforce challenges in construction requires technology adoption and modern training initiatives to secure a sustainable future for the industry predictive maintenance enhances construction operations ensuring safety and efficiency while reducing unexpected costs construction good practice standards will prioritize safety driven by evolving regulations and advanced technologies you can trust me to find commercial scientific answers from AZoNetwork.com please log into your AZoProfile account first Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content A few things you need to know before we start Read the full Terms & Conditions « Back This work, USS John P. Murtha Holds Change of Command, by PO2 Joshua Samoluk, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright MD---Salisbury University senior Dylan Laconich has been selected among the inaugural class of Langenberg Legacy Fellows The fellowship from the University System of Maryland (USM) which aims to foster civic education and civic engagement on and off campus comes with a $1,500 stipend to sponsor a project of the fellow’s choosing an urban and regional planning major from Arnold has long had a passion for civic engagement and giving back to the community in which he lives in particular pertaining to the environment He has been a member of the Environmental Student Association (ESA) a key player in the ESA’s bee project Through that initiative ESA members go door-to-door asking residents if they will help make their yards and gardens more sustainable and pollinator friendly by planting wild flower seeds (which the ESA students offer) creating possible habitats for bees in dead logs on their property and establishing collection areas for water for bees Amal Ali of the Urban and Regional Planning Program he chose to carry on with the environmental basis of the ESA projects reaching out to a broader audience on the Eastern Shore He hopes to bring environmental supporters together with an environmental fair next fall he has been collaborating with the City of Salisbury in hopes that the fair will include farmers who can sell their produce or advertise their services He also would like to allow local environmental groups to participate and educate those in attendance while creating a collaboration between environmental groups and the city to enhance the area’s sustainability the [average] income here in Salisbury isn’t very high so people may push [sustainability efforts] aside but that can have serious cascading effects,” Laconich said very important that people have gardens that are healthy for the air and good for the pollinators so that the ecosystem functions the way it needs to.” Laconich intends to create a presentation for younger attendees to explain how they can become involved in sustainability where they are “Something that we value in urban planning is letting everybody in the community know that they can participate and their voice matters,” he said “If the younger generation knows about these things and they know how to get involved they’ll feel like they appreciate their community more and their community appreciates them Hopefully it becomes not just a more sustainable community Laconich will be working with SU’s Institute for Public Affairs and Civic Engagement (PACE) and the City of Salisbury’s Community Relations Department and Green Team to prepare the event The Langenberg Legacy evolved from the Langenberg Lecture and Award Program established to honor former USM Chancellor Donald N Learn more about how SU students and faculty make tomorrow theirs at the SU website. Have an SU story idea to pitch to the PR Office? Visit the PR Office homepage for the appropriate contact. Watch 4m 22sWhy do Tasmania's new giant ferries have nowhere to berth? Reporter Adam Langenberg takes us through the Spirit of Tasmania saga. CNN and the BBC World Service which is copyright and cannot be reproduced AEST = Australian Eastern Standard Time which is 10 hours ahead of GMT (Greenwich Mean Time) Denison’s purpose is to inspire and educate its students to become autonomous thinkers discerning moral agents and active citizens of a democratic society We are thrilled that you are considering Denison during your college search and we look forward to getting to know more about you and experiences to campus; see how Denison helps them make this college their own and upcoming events from all around the hill and beyond "Secrecy Is Toxic:" To Sexual Violation In Grassroots Responses To Sexual Violation In American Buddhism An overview and description of the Religion department at Denison University Scholarships and awards given to students each year in Religion at Denison University “Secrecy Is Toxic:” Grassroots Responses to Sexual Violation in American Buddhism American Buddhist communities have been the site of recurring sexual misconduct and abuse allegations Efforts to bring about justice have been hampered by denial and deflection from teachers In the absence of community accountability to a central american buddhist governing body efforts to respond to sexual abuse have fallen largely to individual or collective grassroot efforts we consider grassroots efforts to respond to sexual abuse in American Buddhism These efforts include submitting to outside investigations and trainings community reform through revised grievance procedures and ethics statements survivor advocacy through in-person and online networks We conclude by reflecting on the relationship between such efforts and the sexual ethics found in the classical buddhist tradition a partner at McCollum Hodgkinson & Nikitas is an inductee of the Big Red Athletic Hall of Fame Moser will coordinate K-12 agencies across the state on social and emotional investments for students Stay up to date with the latest campus news and upcoming events Mary Langenberg didn’t have far to go to pay calls on some of the institutions she supported so generously in her long She was by all accounts a vivacious and beautiful woman who loved entertaining her friends and cherished good After living for many years in architecturally traditional dwellings in the Central West End and Clayton she spent her later life in a sleek and elegant modernist aerie on Skinker Boulevard an apartment with a knock-out view of Forest Park and the land beyond Were she to walk across Skinker to follow a path meandering through the woods and meadows The museum is a longtime recipient of the largesse of Mrs who died in 2012 just weeks shy of his 100th birthday Museum director Brent Benjamin recalled her multiple graces – her generosity of fortune and spirit and an ability to put a new acquaintance at his or her ease “She was lovely a person as one could ever care to know,” he said That observation is repeated time and again by those who knew her Langenberg was a frequent visitor to the galleries and often spent lunchtime in the museum’s restaurant with friends were among the largest donors in the history of the museum They endowed a fund for acquisitions of Asian art and when an object was under consideration for purchase the couple would be asked to come to see it Benjamin said often they’d ask that endowment funds be left alone and would put up the money needed to pay for the acquisition on the spot three other important institutions the Langenbergs supported were nearby also Should she journey north on Skinker Boulevard from home in a few blocks she’d come to Wydown Boulevard and up that shady street is the Episcopal Church of St The church and the school were longtime beneficiaries of Mrs She served on the church’s lay governing body energy and financial assistance to the school Michael’s School and co-founder of the Cadwell Collaborative an educational consulting enterprise in Middlebury said he has had two “mentoresses” in his life called Mary – one is his 94-year-old mother She and Ollie gave us the gymnasium for the school and paid for a lot of the playground  But the Langenbergs also were ready with wise counsel beyond the financial “During a time of serious tumult for the school they made it clear what we were doing was what was needed.” Cadwell said also if she disagreed with something or another at the school Skip over a short distance to the north of the church is Washington University another recipient of Langenberg-style attention Langenberg attended the university for a time although she left school because she needed to work chancellor emeritus of Washington University and a founder of the Donald Danforth Plant Science Center He was a frequent guest at her table on Sunday evenings along with a few others close to Mrs “She was a very good person,” Danforth said a grand individual who loved to have people in her home Langenberg were very good to the Plant Science Center Her interest in education and her generosity played out also at City Academy a private middle school at 4175 North Kingshighway in North St Don Danforth is president and co-founder of the school “One of the greatest benefits of working at City Academy is getting to know people who are genuinely interested in the community and its welfare,” Danforth said and she regularly recalled for him the first graduation ceremony of City Academy Langenberg were in attendance and were presented the inaugural Langenberg Prize for outstanding service to the school it acknowledges also the quest for lifelong learning and the importance of giving back to society Langenberg was also was quick to praise those who made sacrifices for the good of children and for providing good educations for them Danforth said he had a special place in his heart for the Langenbergs “They were the first donors to the school – the first not related to me anyway.” Mary Booth Langenberg was born in Springfield into circumstances far more modest than those which she enjoyed in later years was an owner of a restaurant in the heart of Springfield’s political universe she returned to Springfield and landed a clerical job in the insurance business but she was recognized as a comer and she was elevated into managerial jobs In a milieu similar to that portrayed by women executives in “Mad Men,” she encountered the obstacles and resistances women faced in the 1950s who ran the insurance company office in St The bride-to-be moved back to Springfield to take a better-paying position she “got back on the saddle,” and after a while she married Oliver Langenberg William Danforth said “Ollie was very much in love with her businesswoman and former president of the St had a clear picture of the depth of the generosity Mary and Oliver Langenberg extended to the orchestra Langenberg as a friend and neighbor in the Central West End They lived two doors apart on Pershing Place and their children were playmates “She was a remarkable person,” Weldon said “and for those of us who got to know her later in life missed a lot of the experiences that made her so remarkable and were among those who spent time with her on numerous Sunday evenings after Ollie died.” The Langenbergs were symphony regulars in their heyday “The Langenbergs were long-time subscribers and generous supporters They loved the symphony and understood why it is such an important civic asset.” Other organizations and institutions with which she worked include: the St Louis Grand Jury Association (board member) Washington University Women’s Society; Children’s Hospital where she co-ran the gift shop; the Missouri Botanical Garden; the Chatillon-DeMenil Mansion; the Woman’s Exchange summed up the life and work of Mary Langenberg succinctly “Mary's clarity and graciousness were shared with family friends and the community in many and significant ways She had a way of seeing the essential thing and then working with others to make things better I will miss her warm friendship and wise counsel.” The family asks that donations be made to Chatauqua Institution 14722 or to the Donald Danforth Plant Science Center (Carolyn); her grandchildren: Olivia Lee Polk William Jackson Polk and Samuel Finnegan Polk; and her stepchildren: Peter Morton Langenberg (Marilyn) and Alice Langenberg Abrams (Walter).  HOSKINS — A celebration of life for Gene “Geno” Langenberg at the Hoskins Community Center in Hoskins GRAND ISLAND — A celebration of life for Elaine L at Peace Lutheran Church in the life center in Grand Island with the Rev