Infectious diseases have long taken a toll on healthcare services but
which sparked a worldwide pandemic of monumental proportions
The World Health Organization (WHO) declared a Public Health Emergency of International Concern following the first reported cases of SARS-CoV-2 in early 20201 and
the exact figure for the number of Covid-19 related deaths is still debated
but many agree that there were upward of 3.3 million deaths worldwide by the end of 2020.2 Hospital-acquired infections are thought to have contributed to these cases significantly
putting healthcare workers and vulnerable patients at risk.3
Nosocomial infections already posed a serious threat to healthcare institutions across the globe long before the Covid-19 pandemic, affecting approximately 6.5 % of hospitalised patients in the European Union (EU) and European Economic Area.4 One of the main culprits is tuberculosis (TB)
which was responsible for an estimated 32,000 deaths worldwide in 2015 alone.5 Although rates for TB in Europe as a whole are actually comparatively lower than in other parts of the world
it remains a public health crisis as incidences are on the rise in certain high-risk TB areas.5 Not only this
but the evolution of extensively multi-drug resistant TB – unaffected by the usual first- and second- lines of antibiotics – is most prevalent in this area of the world and a key driver of the European TB epidemic.6 Reports also demonstrate that total TB-related deaths have increased significantly as a result of the Covid-19 pandemic.7
The spread of infections of any kind can have devastating consequences
particularly in healthcare environments with vulnerable patient populations – the young
the elderly and the immunocompromised – not to mention the risk to staff wellbeing
The dynamic nature of hospital environments and the vast numbers of patients
visitors and staff who enter their doors daily can allow pathogens to spread quickly
leading to endless sources of infection.
Institutions worldwide are doing everything in their power to prevent hospital-wide outbreaks
and rapidly diagnosing infectious diseases is an effective method to determine risk.9 For this
molecular methods remain the gold standard for diagnosing respiratory infections in a clinical setting
Rapid antigen tests are adequate for diagnosing Covid-19 in symptomatic patients who have high viral loads,10 but they lose accuracy when a patient is further from peak replication.11 The higher sensitivity and specificity offered by molecular tests provide clinical staff with a wider investigative window
meaning they are more likely to result in a correct diagnostic for these patients.
the InnKlinikum – comprising two of the largest and most efficient healthcare providers in the Inn-Salzach region
as well as Burghausen and Haag hospitals – integrated a suite of Cepheid GeneXpert® systems to rapidly test patients for infectious diseases
Head of the Laboratory at the Altötting and Mühldorf hospitals
explained: “Mühldorf hospital has worked with the GeneXpert system for several years and integrated it into its diagnostic workflow for various infectious diseases
when all four hospitals joined together under the umbrella of the InnKlinikum in 2020
our other units were able to see firsthand just how beneficial this instrument could be.”
and we were left with no choice but to seek a reliable and efficient means of PCR testing patients for SARS-CoV-2,” Maier continued
“The demand grew exponentially as we began testing patients in the emergency room before admission
We did everything we could to avoid placing anyone onto the ward
where they could mingle with staff members and vulnerable patients
without confirmation of a negative SARS-CoV-2 PCR test
as we serve up to 45,000 inpatients every year and house 972 beds
testing became a significant bottleneck as we didn’t have the necessary capacity
flexible and easy-to-implement PCR system that could deliver results quickly and fit harmoniously into our workflow.”
“We swiftly turned to our Cepheid contacts
who set up a new GeneXpert system very quickly
expanding our scope for testing from one small device in Mühldorf hospital to an additional sixteen-channel instrument in Altötting,” Maier continued
“This system allows us to run eight patients’ samples simultaneously and individually with extremely few failures
It’s as simple as inserting the pipette sample
The device also provides much more clinical data than other systems on the market with amplification curves
allowing us to troubleshoot and determine whether the results are analytically clean
the Xpert® Xpress CoV-2/Flu/RSV plus test screens for SARS-CoV-2
We have worked with Cepheid for many years
and already knew that these systems are extremely robust and very rarely experience failures
giving us confidence that each cartridge would produce a usable result.”
Maier elaborated: “The decision to work with Cepheid was more than just convenience
The company has always shown us that it stands for rapid and accurate qualitative and quantative diagnostic tests
and demonstrates significant know-how in PCR – and point-of-care PCR testing in particular
The market during the pandemic was full of uncertainty
as young companies sprung up quickly to answer the demands for PCR testing
with very little – or sometimes no – experience in diagnostics
we knew that Cepheid devices could deliver on the quality and robustness that we needed
We are now looking forward to expanding our testing to various other diseases
which is an easy addition given the modularity of the system.”
To find more information, please click here.
The tool has made it possible to detect SARS-CoV-2 in exudate from symptomatic patients with a sensitivity of 100% and a specificity of 87.5%
When point-of-care testing (POCT) models for diagnosing infectious disease are effective
the quality of pathology results can be equivalent to laboratory tests
a non-profit hospital and medical research institution in Los Angeles
is setting new standards for quality and innovation in patient care by successfully introducing…
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haben Verkehrsminister Peter Ramsauer und Bahnaufsichtsratschef Professor Utz-Hellmuth Felcht den zweigleisigen Abschnitt zwischen Altmühldorf und Ampfing eröffnet
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Den knapp zwei Dutzend Demonstranten der SPD-Kreisverbände Altötting und Mühldorf blies eiskalter Wind ins Gesicht
Tapfer rasselten sie mit ihren Ketten und stimmten das Lied von der schwäbischen Eisenbahn an
begrüßt von der Blasmusik der Stadtkapelle Mühldorf
Doch nicht lange klangen die musikalischen Misstöne über das Gelände
fand versöhnliche Worte: "Es ist ja schön
dass die Infrastruktur verbessert wird"
sagte der ehemalige Chef des Trostberger Chemieunternehmens SKW und bat die Demonstranten ins beheizte Festzelt am Bahnhof
Dort versammelten sich zahlreiche geladene Gäste
Bayerns Wirtschaftsminister Martin Zeil kam entgegen seiner Ankündigung allerdings genauso wenig wie Bahnchef Rüdiger Grube
Vielleicht ist die aktuelle politische Konstellation trotzdem ein Glücksfall für die Region
Das war zumindest am Rande der Eröffnung immer wieder zu hören: Ein Verkehrsminister aus Traunstein
ein ehemaliger Chemiechef aus Trostberg als Aufsichtsratsvorsitzender der Bahn und 2013
wenn der nächste Ausbau Richtung Tüßling ansteht: Bundestagswahlen
In dieses Bild passten die Aussagen des Samstags
Eine "Mittelaufstockung des Bedarfplans Schiene"
zum "bedarfsgerechten Ausbau der Bahnstrecke" bekannte sich Verkehrsminister Ramsauer
Das gelte zunächst vor allem für den Ausbau zwischen Mühldorf und Tüßling
für den der Planfeststellungsbeschluss 2013 vorliegen soll: "Und dann werden wir auch unverzüglich die dazu notwendige Finanzierungsvereinbarung unterschreiben"
7,8 Kilometer ist der am Samstag eingeweihte
zweigleisige Abschnitt zwischen Altmühldorf und Ampfing lang
von denen der Bund nach Angaben Ramsauers 33,8 Millionen Euro bereitgestellt hat
Als Meilenstein bezeichnete Ramsauer den Ausbau
auch Bayerns Bahnchef Klaus-Dieter Josel betonte mit Blick auf das neue elektronische Stellwerk Burghausen und den Neubau der Ehringer Innbrücke: "Sie sehen
soll Baurecht für den Abschnitt zwischen Altmühldorf und Tüßling gelten
die Pläne seien fertig und würden beim Eisenbahnbundesamt eingereicht
Auch für das dritte Gleis zwischen Freilassing und Salzburg könne es in zwei Jahren Baurecht geben
Der Verkehrsminister hielt am "langfristigen Vorhaben des kompletten Ausbaus und der Elektrifizierung der Strecke" zwischen München und der Grenze mit Österreich fest
Statt wie bisher vom Ausbau zweiter Begegnungsabschnitte zwischen Markt Schwaben und Hörlkofen sowie zwischen Dorfen und Obergeiselbach zu sprechen
erklärte Ramsauer den gesamten Ausbau zum Ziel
Er brachte außerdem einen zweigleisigen Abschnitt zwischen Kirchweidach und Tittmonnig auf der Strecke Richtung Freilassing ins Spiel
durften die Ehrengäste bei einer Fahrt nach Ampfing erleben: Auf halber Strecke überholte ein Güterzug den Regionalzug
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