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Eckes-Granini has been using 25% rPET in its hohes C PET juice bottles since 2018 the new PET juice bottle from Eckes-Granini is 100% rPET.“Considering the EU’s plastics strategy and the increase in recyclate quotas this prescribes we’ve now decided to switch to using recycled PET only,” says Hermann Naumann plant manager for Eckes-Granini in Bad Fallingbostel in Lower Saxony “We want to be a pioneer with regard to the circular economy and set a good example for the beverage industry.” Europe’s leading producer of fruit juice beverages has pursued an ambitious sustainability strategy for years “We aim to continue steadily reducing our carbon footprint in production and in our packaging This means not only cutting down on the amount of material used but also closing the recycling loop.” With help from the KHS Group (https://www.khs.com/en/) since the middle of May the firm’s 1-L hohes C juice bottle has consisted entirely of recycled plastic (rPET) KHS’ Bottles & Shapes experts in Hamburg were responsible for optimization of the bottle The new containers will continue to be produced on the tried-and-tested InnoPET FreshSafe block the changeover of the 1-L hohes C bottle to rPET will save over 4,000 metric tons of new PET annually This in turn means that the bottler will cut its carbon emissions by about 8,000 tons a year Finding ways of saving on resources was not the only focus of the ambitious project The ability to do so on the KHS InnoPET FreshSafe block in operation at Eckes-Granini since 2017 also had to be investigated “One of the concerns was whether either the preforms or machine would need modification,” explains Dr “So we carefully assessed the quality of the recycled PET material or inhomogeneity can quickly reduce the efficiency of production.” The fact that Eckes-Granini procures its preforms from two different suppliers presented an added challenge The geometry of the preform is essential for efficient processing especially when a high percentage of rPET is used Through extensive testing it was established that both makes of preform function soundly on the block system All that was needed for optimum bottle production were minor adjustments to the heater on the stretch blow molder No major changes to the machinery or geometrical properties of the preforms were required “This enabled us to achieve a very high level of process efficiency while retaining the container quality thus fully meeting our customer’s requirements,” says Kruse Eckes-Granini will continue to benefit from FreshSafe PET barrier protection also after converting to 100% rPET The beverage company has relied on the environmentally-friendly system from KHS since 2006 The oxygen barrier of chemically pure glass a wafer-thin coating on the inside of the PET bottle not only effectively protects the juice from oxygen pickup but is also fully recyclable The coating can be easily washed off Eckes-Granini bottles during the recycling process The sustainable packaging alternative therefore permits pure-grade bottle-to-bottle recycling “By combining rPET and future-proof product protection Eckes-Granini and KHS are again demonstrating their pioneering role for the circular economy,” claims Kruse. PACK EXPO Las Vegas and Healthcare Packaging EXPO (Sept Las Vegas Convention Center) will reunite the packaging and processing community while implementing up-to-date protocols for a safe and successful in-person event Metrics details Conjunctival melanoma is a potentially deadly eye tumour tumour recurrence and metastasis remain frequent The genetics of conjunctival melanomas remain incompletely understood A large cohort of 63 conjunctival melanomas was screened for gene mutations known to be important in other melanoma subtypes by targeted next-generation sequencing Mutation status was correlated with patient prognosis Frequent mutations in genes activating the MAP kinase pathway were identified Recurrent activating mutations were also identified in BRAF (n = 16 conjunctival melanomas can be grouped genetically into four groups: BRAF-mutated NF1-mutated and triple wild-type melanomas This genetic classification may be useful for assessment of therapeutic options for patients with metastatic conjunctival melanoma recurrent mutations in other genes have not been identified Our study aimed to further elucidate genetic events in conjunctival melanoma by analysing a large tumour cohort with a targeted next-generation sequencing assay covering genes that are recurrently mutated in cutaneous and uveal melanoma Sixty-seven conjunctival melanoma samples were obtained from the tissue archives of the Departments of Ophthalmology Dermatology and Pathology of the University Hospital Essen The study was approved by the local ethics committee of the University of Duisburg-Essen with a minimum coverage of 30 reads in >80% of the target loci Four samples were excluded from analysis due to low coverage ≥10 reads reported the mutated variant and the frequency of mutated reads was ≥10% Associations of mutation status with available clinico-pathological parameters (listed in Table 1) were explored Analyses were performed with IBM SPSS Statistics software (version 20.0; International Business Machines Corp. A p-value of <0.05 was considered statistically significant Activating BRAFV600E (c.1799A>T) mutations were detected in 16/63 (25%) tumours. Additionally, 4 BRAF mutations with unknown functional consequences were identified (Supplemental Table 2) Activating RAS mutations (11 NRAS and 1 KRAS mutation) were identified in 12/63 (19%) tumours (Table 2). We also detected 4 NRAS, 3 KRAS and 5 HRAS mutations with unknown functional consequences (Supplemental Table 2) There were no statistically significant associations between clinico-pathological parameters with BRAF, RAS and NF1 mutation status (Table 1) the present study represents the most detailed analysis of gene mutations in conjunctival melanoma to date mutations in all three RAS genes are grouped together as RAS-mutated melanomas our study identifies a range of mutations in conjunctival melanoma with RAS gene mutations occurring not only in NRAS but also KRAS and NF1 mutations being frequent in tumours lacking BRAF or RAS mutations suggests that the proposed genetic classification of cutaneous melanomas into BRAF-mutated NF1-mutated or triple-wild-type tumours is also applicable to conjunctival melanoma Current appraisal of conjunctival melanocytic tumors: classification and treatment Conjunctival melanoma: risk factors for recurrence Orbital exenteration in 95 cases of primary conjunctival malignant melanoma Long-term follow-up of patients with conjunctival melanoma Conjunctival melanoma in the Netherlands: a nationwide study Conjunctival melanoma: pitfalls and dilemmas in management et al.Mutations of the BRAF gene in human cancer NF1 mutations are common in desmoplastic melanoma Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus Genomic classification of cutaneous melanoma Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas Genetic alterations and personalized medicine in melanoma: progress and future prospects Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4 Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3 Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma Frequent mutation of BAP1 in metastasizing uveal melanomas Integrative analysis identifies four molecular and clinical subsets in uveal melanoma SF3B1 and BAP1 mutations in blue nevus-like melanoma Activating CYSLTR2 and PLCB4 mutations in primary leptomeningeal melanocytic tumors BRAF mutations are detectable in conjunctival but not uveal melanomas Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600E gene mutation and gene copy number changes T1799A BRAF mutations in conjunctival melanocytic lesions Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours Prevalence and implications of TERT promoter mutation in uveal and conjunctival melanoma and in benign and premalignant conjunctival melanocytic lesions KIT gene mutations and copy number in melanoma subtypes Improved overall survival in melanoma with combined dabrafenib and trametinib Pembrolizumab versus Ipilimumab in Advanced Melanoma Combined nivolumab and ipilimumab or monotherapy in untreated melanoma Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma Conjunctival melanomas harbor BRAF and NRAS mutations--response Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system BRAF mutations in conjunctival melanoma: investigation of incidence Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations Targeted next generation sequencing identifies markers of response to PD-1 blockade Download references We would like to thank Nadine Stadler and Nicola Bielefeld for their excellent technical support. The research was supported by a grant from Dr. Werner-Jackstädt-Stiftung (www.jackstaedt-stiftung.de) and Hiege-Stiftung gegen Hautkrebs This work was also funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748 and received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 641458 decision to publish or preparation of the manuscript University Duisburg-Essen and the German Cancer Consortium (DKTK) Dirk Schadendorf is on the advisory board or has received honararia from Roche The other authors declare no competing interests Note: This work is published under the standard license to publish agreement After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International licence (CC BY 4.0) This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) provided you give appropriate credit to the original author(s) and the source provide a link to the Creative Commons license Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41416-018-0046-5 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article some of them were spat on and ended up in the garbage The results of the experiment reveal Israel’s problematic situation in the country along with posing some serious questions relating to German society Sports Gazette The sports magazine brought to you by the next generation of sport writers Sébastien Haller had been waiting for this moment since July The Borussia Dortmund striker was finally back on the pitch after his testicular cancer diagnosis almost half a year ago In a friendly against Basel last weekend he succeeded again at what he does best: scoring goals Just in time before the Bundesliga returns on 20 January he is ready for his first league game with the Borussia The Ivory Coast international had joined Dortmund from Ajax Amsterdam last summer The striker is only one of four Bundesliga players who were diagnosed with this particular disease in the span of six months Marco Richter (both playing for Hertha BSC Berlin) and Timo Baumgartl (Union Berlin) are the other names on the list Haller is the last one to return to the pitch Along with Baumgartl he had to endure the longest rehab period including two operations and chemotherapy Due to the unusual accumulation of testicular cancer in the Bundesliga the media and public took notice of this phenomenon Is there a specific reason or any correlation between these cases in the Bundesliga Does football maybe even increase the chances of getting the disease The answer to both questions is no according to several specialists including Dr the media made this a bigger issue than necessary Photo: Martin Dötsch at his office in Nieder-Olm near Mainz; Source: urologenniederolm.de Headlines like “Higher testicular cancer risk for professional football players?” or “Does professional football cause testicular cancer?” were often misleading Hamburg urologist Prof. Dr. Frank Sommer even spoke about international studies that seemingly showed “that boys who play extremely strenuous competitive sports before puberty have an increased risk of testicular cancer, independent of genetic factors.” Dötsch assures that there are not any known factors in sports that increase testicular cancer It is normal for young men to be affected by this disease but “the fact that it is now affecting footballers in particular is a coincidence.” The main reason for the great media attention is the fact that these are well-known professional players it would not have become a topic of discussion,” the urologist believes While the tumor overall is relatively rare it is the most common cancer among young men and has to be treated This normally includes an operation and ,if necessary the chance for recovery is higher than for cancer at an older age he had to undergo a second larger operation which is why he missed all games before the winter break Although Dötsch sees it as a positive development that the cases in the Bundesliga have made the general public more sensitive to the issue “one must also not overstate or exaggerate it” because this has led to many young men coming to his office with only a mere suspicion of a tumour They turned out to have no problems at all a preventive examination by a urologist does not make sense “because you notice the testicular cancer yourself when it comes You don’t need a doctor for that,” he says “You’re standing in the shower and you notice that there’s something that wasn’t there before Early detection of testicular cancer is something you do yourself testicular cancer is relatively rare and mostly affects men between 15 and 49 years of age Only just under two percent of all cancers are testicular cancers It is important to distinguish between testicular and prostate cancer While testicular cancer mainly affects young men and is self-detectable the situation is different with prostate cancer It represents the most frequent cancer after lung cancer it is advisable to go to early recognition screenings starting from the age of 45 according to Dötsch This type of cancer can still be treated well in the early stages but at the same time it is difficult to detect it without a doctor Hertha BSC winger Boëtius was the last player to get the testicular cancer diagnosis – in September 2022 Only a month later he was able to return to the pitch starting with individual training until making his comeback only four weeks after his diagnosis For Marco Richter it was a similar relatively easy recovery He celebrated his comeback with a dream goal shortly after this had to undergo chemotherapy to treat the disease Baumgartl has returned to the pitch in September 2022 and has spoken out about the process after his diagnosis in the media multiple times The 26-year-old described the days when he started chemotherapy as “the most difficult moments of my life” This even led to all his teammates from Union Berlin going for a check-up for testicular cancer Another case of an overcautious reaction on the matter In Premier League history only handful of players came forward with their diagnosis for example Arjen Robben (Chelsea) in 2004 and Jonas Gutierrez (Newcastle United) in 2013 It should be kept in mind that some players who caught the disease probably did not go public with it the Bundesliga set a positive example by tackling what was previously often handled as a taboo topic the number of testicular cancer cases has increased significantly in the last 50 years The number of cases each year in the UK has roughly doubled since the mid-1970s according to the NHS (2019) but a number of factors that could increase of a man’s developing it have been identified These include family history and previous testicular cancer disease Some doctors even claim that sport could possibly decrease the chances of getting the disease Typical symptoms are a painless swelling or lump in one of the testicles or any change in shape or texture of the testicles “Testicular cancer is the only solid tumour that can be cured with a very good prognosis Charities like “Movember” are dedicated to battling men’s health issues Apart from mental health and suicide prevention their other focuses are on prostate and testicular cancer the Movember movement has become a global one men make the public aware of those issues by growing a moustache throughout the month “with the aim of raising vital funds and awareness of men’s health issues.” the organisation has in the past been criticised for its recommendations for the frequency of screening which are at times at odds with NHS recommendations This leads to the conclusion that the most important part of the mission should be to create a common understanding a more open conversation around issues such as testicular cancer will help make more young men aware of the potential health concerns they face and feel empowered to handle them rather than feel ashamed Dötsch is adamant that this is having a positive effect He says: “My attention has remained the same but that of the young men has increased.” is a writer and social media editor for the Sports Gazette where she studied sports science at TU München Her passions are writing and (playing) football She played for the second team and U17 of FC Bayern Munich Her main goal is to increase the coverage of women's sports in the media Y"},"category":false,"taxonomy":{"active":false,"name":"category"}},"markup":{"custom_html":true,"wpp-start":"","wpp-end":"<\/ul>","title-start":"","title-end":"<\/h2>","post-html":"{thumb} {title} {stats}<\/span><\/li>"},"theme":{"name":""}}