and is expected to reach USD 1.48 Billion by 2030 This growth can be attributed to factors such as increased awareness of digital pathology and its benefits collaborative initiatives by healthcare organizations and efforts by industry players to promote the use of digital pathology for enhancing the accuracy of cancer diagnostics in the region the total number of Disability-Adjusted Life Years (DALYs) due to neurological diseases stands at 64.4 million in the Southeast Asia region and 85 million in the Western Pacific region.Key Market Drivers Rising Adoption of Telemedicine and Remote Patient MonitoringThe increasing adoption of telemedicine and remote patient monitoring (RPM) across the Asia-Pacific region is a key growth driver for the digital diagnostics market and access to medical services remains limited in rural areas digital diagnostic tools offer solutions that enable healthcare providers to diagnose and manage patient conditions remotely.Devices like wearable technologies and mobile health applications allow clinicians to access real-time health data facilitating timely diagnoses and interventions The COVID-19 pandemic has accelerated the shift to telemedicine and the demand for remote consultations and diagnostics is expected to continue post-pandemic further enhancing healthcare delivery in the region This growth is supported by advancements in mobile technology and optimized healthcare efficiency.Key Market Challenges Data Privacy and Security ConcernsA major challenge facing the growth of the digital diagnostics market in Asia-Pacific is concerns surrounding data privacy and security The collection and storage of sensitive patient information via digital health tools heighten the risk of cyberattacks Several countries in the region lack standardized regulations and frameworks to address these concerns effectively The absence of strong data security measures creates hesitation among both healthcare providers and patients regarding the adoption of digital diagnostic technologies the challenge of complying with varying data protection laws across different countries in the region adds complexity for companies operating in the digital diagnostics sector.Key Market Trends Integration of Wearable Health DevicesWearable health devices are rapidly gaining traction in the Asia-Pacific region These devices continuously collect data on vital health parameters which can be analyzed to monitor chronic diseases and detect early warning signs of medical conditions With the increasing focus on preventive healthcare and growing adoption of personal health monitoring the integration of wearable devices into digital diagnostics is on the rise These devices empower patients with greater control over their health while enabling healthcare providers to track patient progress and intervene when necessary Advancements in technology have made these wearables more sophisticated enhancing their capabilities for real-time diagnostics and health management.Key Players Profiled in Asia-Pacific's Digital Diagnostics Market About ResearchAndMarkets.comResearchAndMarkets.com is the world's leading source for international market research reports and market data We provide you with the latest data on international and regional markets All 5 Releases All 5 Releases Volume 12 - 2021 | https://doi.org/10.3389/fpls.2021.715985 This article is part of the Research TopicGenomics-enabled Triticeae ImprovementView all 15 articles The seed protein α-gliadin is a major component of wheat flour and causes gluten-related diseases due to the complexity of this multigene family with a genome structure composed of dozens of copies derived from tandem and genome duplications little was known about the variation between accessions and thus little effort has been made to explicitly target α-gliadin for bread wheat breeding we analyzed genomic variation in α-gliadins across 11 recently published chromosome-scale assemblies of hexaploid wheat We unexpectedly found that the Gli-B2 locus is not a single contiguous locus but is composed of two subloci suggesting the possibility of recombination between the two during breeding We confirmed that the number of immunogenic epitopes among 11 accessions varied The D subgenome of a European spelt line also contained epitopes in agreement with its hybridization history Evolutionary analysis identified amino acid sites under diversifying selection The analysis opens the way for improved grain quality and safety through wheat breeding Since its origin by allopolyploidization, bread wheat (Triticum aestivum L.) has become a staple crop, providing ∼20% of the calories consumed globally (Shiferaw et al., 2013). Concentrated breeding efforts have increased yield such that the production of bread wheat reached 766 million tons in 2019 (FAOSTAT, 2021) Further selection has made wheat more palatable and increased the quality of desired end-use traits Sequence-based characterization of α-gliadin variation within modern hexaploid wheat cultivars will aid in breeding efforts to incorporate both desired end-use quality and lower reactivity for consumers we began to address the question of global variation in both the structure of and polymorphism within Gli-2 loci among multiple cultivars with the units for branch lengths being the same as those of the evolutionary distances used to infer the phylogenetic tree Using the amino acid sequences of α-gliadin copies without the last stop codon, we searched all sequences for the presence of nine canonical amino acid epitopes previously shown to induce an immunogenic reaction (Sollid et al., 2012; Ozuna et al., 2015) The consistency in the Hi-C maps observed among all assemblies supports that Gli-B2 is composed of two parts and opens the possibility of exploiting genetic recombination for breeding purposes Genomic positions of Gli-2 loci in 11 wheat accessions this suggested that the rearrangement in CDC Landmark may represent true biological variation The location and orientation of these subloci remain interesting cases for further validation to distinguish biological rearrangement from assembly errors While the three α-gliadin copies at high coverage likely represent collapsed paralogs the four genes at lower coverage may be haplotype-specific assemblies of heterozygous allelic copies The long-read data suggested that the assembled α-gliadin sequences were correctly identified although the exact copy number of ∼20% of them may be different An extremely high or low copy number for Gli-B2 and Gli-D2 in Jagger Subsequent analyses in this paper will use the assignment to a particular Gli-2 locus based on previously published assemblies for consistency the two gliadin sequences encoded in Gli-B2-2 formed subclades distinct from other sequences in Gli-B2-1 indicating that the split of Gli-B2 was shared among all wheat accessions and that the genes in the two subloci experienced different histories These data further support the bipartite structure of Gli-B2 Phylogenetic relationship of α-gliadin copies in 11 wheat accessions The 429 α-gliadin copies showed clustering based on subgenome assignment The evolutionary tree is largely divided into three clades Each subclade is indicated by the arcs and colored according to the corresponding Gli-2 loci Numbers at branch splits are bootstrap percentages Copies assigned to loci to which they do not cluster are indicated by arrows: Gli-B2-3 in Jagger are in blue and Gli-D2 in CS and LongReach Lancer are in orange Spelt copies are highlighted in light purple The red curve in clade 3 highlights the seven sequences containing the immunotoxic 33-mer Despite these potential misclassifications we were able to show that there were clear variations among accessions Among the accessions with the largest differences in copy numbers Branches from accessions with the highest copy number for Gli-A2 were clearly separated from the branches of the other seven accessions we found distinct clusters containing copies of Gli-B2-1 from ArinaLrFor contained the lowest copy number within this locus These examples highlight potential differences in evolutionary and/or breeding history between accessions and that the gene duplications or losses in some cultivars did not originate independently but were likely from a common ancestor This result also indicates that the introgressed loci from chromosome 6B of emmer wheat may be confined to the region encoding Gli-B2-1 further supporting a different evolutionary history for the two Gli-B2 loci identified in this study Celiac disease (CD) epitope quantification within α-gliadin copies The frequency of canonical CD epitopes varies between accessions and homoeologous chromosomes Sites that were difficult to align in the polyglutamine domains are excluded This warrants further functional validation via amino acid substitution experiments indicating that detailed cultivar-specific analysis is needed While the immunogenic effects of many of the polymorphic epitopes have not been directly tested our main findings indicate that resources for breeding less reactive wheat are already present in elite germplasm Publicly available datasets were analyzed in this study. This data can be found here: IPK, Germany (https://wheat.ipk-gatersleben.de/) INRAE, France (https://wheat-urgi.versailles.inra.fr/Seq-Repository/Assemblies) and KK performed the identifications and phylogenetic analyses of α-gliadin genes and MH performed the epitope identification and evolutionary analyses within α-gliadins DC and MM performed and curated the bioinformatic data All authors contributed to the article and approved the submitted version This work was supported by JST CREST (JPMJCR16O3) the Swiss National Science Foundation 31003A_182318 MEXT KAKENHI The Birth of New Plant Species (JP16H06469) the University of Zurich Research Priority Program Evolution in Action to KKS the National Agriculture and Food Research Organization (NARO) Vice President Fund to HH and the NBRP Genome Information Upgrading Project 2017 The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher We thank Sean Walkowiak and Curtis Pozniak (Crop Development Centre Canada) for sharing the long-read alignments The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpls.2021.715985/full#supplementary-material Supplementary Figure 1 | Large-scale chromosome organization around the Gli-B2 loci in 11 accessions Hi-C contact matrices of chromosome 6B at 0–100 Mb show a strong signal on the diagonal and a relatively even gradient perpendicular to the diagonal indicating that the large-scale structure of assemblies is correct Dashed lines represent the position of each sub locus identified in Gli-B2 Supplementary Figure 2 | Interchromosomal interactions between chromosomes 6B and 6D for each accession Interactions between these chromosomes are weak apart from small regions that show dark vertical lines (e.g. representing evidence of possible misassembly Supplementary Figure 3 | Alignment of LongReach Lancer and CDC Landmark chromosome 6B to that of Chinese Spring (CS) LongReach Lancer may have inversions compared with CS though interrupted by assembly gaps and indels the region is assembled in CDC Landmark with the same orientation as that in CS Supplementary Figure 4 | Validation of the Gli-2 loci with long-read data. Oxford Nanopore Technologies long reads of CDC Landmark were aligned to the short read-based assembly of the same variety (Walkowiak et al., 2020) Alignments at the Gli-2 loci were inspected for overall structure [(A) Gli-A2a on chr6A 25.7–26.5 Mb] and at the single-gene scale [(B) Gli-B2-1a on chr6B] the sequence of the coding regions was well supported by multiple reads Supplementary Table 1 | Gene copy name, chromosome with start and stop position, gene annotation (if available) from Walkowiak et al. 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Kobayashi, Hatakeyama, Kanamori, Wu, Mascher, Kawaura, Shimizu and Handa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Hirokazu Handa, aGlyb2thenVAa3B1LmFjLmpw; Kentaro K. Shimizu, a2VudGFyby5zaGltaXp1QHV6aC5jaA== †These authors have contributed equally to this work Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish The 5-year olds Elysee and the 6-year old Danzarino OLD won the Bundeschampionate qualification classes held at the regional show in Nussloch on 25 May 2015 That same weekend a qualifier took place in Moosburg where the 5-year old Sandokan and the 6-year olds Dixel and Donna Regina claimed the trophies At the Nussloch Bundeschampionate qualifier Franz Trischberger and Ludwig Fischer's Bavarian mare Elysee (by L'Espoir x Ehrentanz I) topped the leader board with an 8.2 total The bay mare scored 8.5 for trot and canter 7.5 for submission and 8.5 for general impression Silke Bechtel and the German sport horse stallion Qaitui (by Quaterback x Abanos) were second with 8.1 In the 6-year old division Katrin Burger aced the class aboard Lothar Merkt's Oldenburg stallion Danzarino (by Diamond Hit x Laurentio) Julia Machat and the Baden Wurttemberger bred Diddle Dee K (by Damon Hill x Carnando) were second with 7.8 At the Moosburg Bundeschampionate qualifier Rudolf Widmann rode Larissa-Cynthia Jacob's Hanoverian gelding Sandokan (by San Amour x His Highness) into the winner's circle with an 8.5 score 8 for canter and submission and 8.5 for general impression Widmann also captured second place on Rose of Bavaria (by Bordeaux x Florestan) with 8.4 In the 6-year old division Jan Disterer and Ramona Ritzel tied in first place with an 8.0 score Disterer and his Hanoverian gelding Dixel got 8.5 for walk and trot 7 for submission and 8 for general impression 7.5 for canter and submission and 8.5 on general impression with her bay mare Donna Regina (by Don Frederico x Lauries Crusador xx) Photo © LL-foto Results - 2015 Bundeschampionate Qualifier - Nussloch Results - 2015 Bundeschampionate Qualifier - Moosburg Related LinkEurodressage Coverage of the 2015 Bundeschampionate Stalls for Rent at Durondeau Dressage in Peer, Belgium Exceptionally Well Located Equestrian Facility in Wellington, Florida Well-built Equestrian Estate With Multiple Business Opportunities in Sweden Stable Units for Rent at Lotje Schoots' Equestrian Center in Houten (NED) For Rent: Several Apartments and Stable Wing at High-End Equestrian Facility Stable Wing Available at Reiterhof Wensing on Dutch/German border Real Estate: Well-Appointed Country House with Extensive Equestrian Facility in the U.K. Rémi Blot Columbia College | Columbia University in the City of New York who closed his laboratory at UC San Francisco last summer says he came upon the focus of his lifelong work largely by circumstance “I hadn’t planned to do research on STDs,” he said in a Class Note sent to CCT last year and living in San Francisco through the Summer(s) of Love provided plenty of opportunity and this gave us chances to make real contributions to public health.” Schachter in the Bronx and was the first in his family to attend college he earned a master’s in physiology from Hunter College in 1960 and a Ph.D His first academic job was as an assistant research microbiologist at UC San Francisco Studies in Schachter’s laboratory focused on the epidemiology and clinical manifestations of chlamydial infections Schachter recognized that chlamydia was not just an ocular or sexually transmitted disease but also a systemic one that caused pneumonia in newborns screening pregnant women for chlamydia and treating the infected women has become the standard of care in the United States and many other countries His laboratory also produced a proof of concept study showing the effectiveness of community-wide treatment of trachoma with azithromycin This is now the linchpin of an effort sponsored by the World Health Organization at eliminating the disease Schachter kept his academic appointment and planned to continue analyzing data and writing up his last few studies it has been a blast,” he said of his career Schachter was predeceased by his first wife Published three times a year by Columbia College for alumni Columbia Alumni Center622 W. 113th St., MC 4530, 6th Fl.New York, NY 10025212-851-7852cct@columbia.edu Columbia Alumni Center622 W. 113th St., MC 4530, 4th Fl.New York, NY 10025212-851-7488ccalumni@columbia.edu Metrics details Ice core and marine archives provide detailed quantitative records of last glacial climate changes whereas comparable terrestrial records from the mid-latitudes remain scarce Here we quantify warm season land-surface temperatures and precipitation over millennial timescales for central Europe for the period spanning 45,000–22,000 years before present that derive from two temporally overlapping loess-palaeosol-sequences dated at high resolution by radiocarbon on earthworm calcite granules Interstadial temperatures were 1–4 °C warmer than stadial climate a temperature difference which is strongly attenuated compared to Greenland records We show that climate in the Rhine Valley was significantly cooler during the warm season and overall drier with annual precipitation values reduced by up to 70% compared to the present day We combine quantitative estimates with mesoscale wind and moisture transport modelling demonstrating that this region was dominated by westerlies and thereby inextricably linked to North Atlantic climate forcing Tundra gley horizons are represented in grey and palaeosols (Cambisols) in brown Tundra gley horizons are represented in grey and arctic/boreal brown soils in brown a Calcaric Cambisol developed at Schwalbenberg suggesting that permafrost features were significantly weaker at Schwalbenberg compared to Nussloch possibly due to the leeward position and southerly aspect of the former Our chronology for Schwalbenberg RP1 is based on 22 dates and spans 39,963–38,162 to 22,150–21,426 cal BP (Fig. 2) We constrain the timespan of the unconformity between units 12 and 13 as a ~5 ka hiatus spanning 30,970–30,199 to 24,619–23,863 cal BP Sedimentation rates range from ~0.5 to 0.6 mm yr−1 for MIS 3 and post 22 cal kBP reaching a peak of 2.0 mm yr−1 between 23 and 22 cal kBP Nussloch sedimentation rates are comparable to those at Schwalbenberg RP1 (~0.5 to 0.6 mm yr−1) Short-lived peaks (up to 1 mm yr−1) in dust accumulation during MIS 2 were constrained to c a Histogram of oxygen and carbon compositions for both sequences; b Schwalbenberg (dark-coloured plain lines) and Nussloch (light-coloured dotted lines) δ13C (‰ VPDB) and δ18O (‰ VPDB) values plotted against the Bayesian age-depth model of the radiocarbon dated sequence using IntCal20 (black horizontal error bars represent 95% confidence levels for modelled ages) Error bars on stable isotope values represent the standard deviation (1σ) of 30 individual measurements per sample of 5 cm thickness ECGs extracted from the interstadial phases (9 samples representing 270 analyses) yielded mean values of −12.5 ± 1.0 ‰ for δ13C and −4.5 ± 1.8‰ for δ18O Results for samples from stadial phases (14 samples representing 420 analyses) yielded mean δ13C and δ18O values of −12.2 ± 1.0‰ and −4.8 ± 1.8‰ respectively ECG stable isotope results are statistically different for interstadial and stadial phases; T-test results yield p-values of 0.04 and 8.9 × 10−6 for δ13C and δ18O respectively The mean carbon isotopic composition values for ECGs from Nussloch are −12.4 ± 0.9 ‰ for interstadials (14 samples representing 420 analyses) and −11.7 ± 0.9 ‰ for stadial phases (4 samples representing 120 analyses) Mean oxygen values of ECGs during interstadials and stadials are −5.2 ± 1.9‰ and −6.3 ± 1.7‰ respectively T-test values of 1.6 × 10−15 and 2.3 × 10−8 for our mean carbon and oxygen isotope ratio values also indicate significant statistical differences between interstadial and stadial phases it then remains to identify the δ18O value of soil water in order to quantify the temperature The Rhine Valley is particularly cold with a mean value of 7.3 ± 4.7 °C during the GS 3 (26–25 ka) the GS 5.1 is slightly cooler with a mean LSTws of 5.0 ± 6.7 °C The timing of the warmest summer phases varies between the two sites; the warmest temperatures occurred at Schwalbenberg during GI 7 (~35 ka) and during GI 12 (~45.5 ka) at Nussloch although it should be noted that GI 12 was not exposed at Schwalbenberg RP1 The timing of the driest conditions also varies between the sites: at Schwalbenberg these prevailed ~22 ka (during the LGM) and at Nussloch were coeval with the coldest phase (Henrich stadial 2) The wettest conditions occurred during the transition from GI 6 to GS 6 (~33 ka) We note that apparent discrepancies in the timing of extreme values between sites reflects the lack of temporally overlapping data for the respective phases The models are obtained for present day and LGM conditions at Nussloch (a Shaded area presents the average precipitation flux at given wind direction/strength (percent of total) precipitation rate (blue dashed) and total precipitation (red dashed Thin solid/long-dashed line circles visualize the scalar/absolute winds and their directions respectively; thin-dashed circle shows wind vector Note that wind direction is meteorological (from where wind blows) Further statistics tabled: VS and VR − absolute and scalar wind speed [m/s] Rw and Rp − rhumbs of maximum wind and precipitation occurrence [percent] rxy − wind zonal and meridional components correlation These mechanisms have probably triggered pre-LGM aridification and cooling in the Rhine Valley this study generates new millennial-timescale quantitative terrestrial climate estimates for the Rhine Valley We see our approach as a first step towards setting up spatially widely distributed data on land-surface temperatures based on ECGs derived from loess-palaeosol sequences which can be compared with other methods such as land snail shell carbonate clumped isotope thermometry Our air circulation models for the present-day and LGM time slices help us contextualize the impact of extreme climate phases on terrestrial environments Our dataset hints at significant correlation between changes in sea ice cover and extent of periglacial aeolian environments (such as the Rhine Valley deposits) over continental Europe during the second half of the last glacial period Although the correlation between temperature and precipitation recorded within the Rhine Valley with higher latitude ice sheet dynamics suggests a passive and more moderate response to hemispheric climate drivers such environments provide an appropriate and quantitative illustration of changes occurring during abrupt climatic transitions we observe comparable trends between loess records from western and eastern central Europe and isotopic proxies from the Greenland ice cores confirming that the Schwalbenberg and Nussloch and archives from central Europe were directly influenced by changes in the North Atlantic climate during the last glacial period ECGs were selected from tundra gley units and brown soil horizons and loess units The sedimentation rates for both profiles were calculated based on age modelling output at 5 cm resolution This might be due to either lower productivity of the earthworms because of climate conditions or lower earthworm populations or both Experiments are still necessary to better constrain parameters that mostly influence the granule production We should be aware that both methods give us a first approximation of climate parameter estimates Values are sampled in respective model grid cells without interpolation Further information on research design is available in the Nature Research Reporting Summary linked to this article All data generated or analyzed during this study are included in this published article (and its Supplementary Information files). 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Rev. https://doi.org/10.1016/j.earscirev.2020.103496 (2020) Rapid and cyclic aeolian deposition during the Last Glacial in European loess: A high-resolution record from Nussloch Dansgaard-Oeschger-like events of the penultimate climate cycle: The loess point of view (MIS3 & 2) millennial oscillations in Greenland dust and Eurasian aeolian records – a paleosol perspective their paleoecological significance and role in geochronology - Principles and methods Biogeography of the Pleistocene pleniglacial malacofaunas in Europe The impact of Dansgaard-Oeschger cycles on the loessic environment and malacofauna of Nussloch (Germany) during the Upper Weichselian High-resolution proxy record of the environmental response to climatic variations during transition MIS3/MIS2 and MIS2 in Central Europe: The loess-paleosol sequence of Katymár brickyard (Hungary) Quatermalacological analyses for modeling of the Upper Weichselian palaeoenvironmental changes in the Carpathian Basin Paleoclimatic reconstruction using mutual climatic range on terrestrial mollusks Climatic transfer-function from quaternary mollusks in European Loess deposits Palaeoprecipitation reconstruction by inverse modelling using the isotopic signal of loess organic matter: Application to the Nußloch loess sequence (Rhine Valley δ13C of Loess organic matter as a potential proxy for paleoprecipitation Branched glycerol dialkyl glycerol tetraethers in Pleistocene loess-paleosol sequences: Three case studies First calibration and application of leaf wax n-alkane biomarkers in loess-paleosol sequences and modern plants and soils in Armenia Reconstruction of the late Quaternary paleoenvironments of the Nussloch loess paleosol sequence Palaeotemperature reconstruction during the Last Glacial from δ18O of earthworm calcite granules from Nussloch loess sequence δ 13C signal of earthworm calcite granules: A new proxy for palaeoprecipitation reconstructions during the Last Glacial in Western Europe Morphology and dynamics of calcium carbonate granules produced by different earthworm species Origin of calcium carbonate granules found in buried soils and Quaternary deposits Earthworm calcite granules: a new tracker of millennial-timescale environmental changes in Last Glacial loess deposits High-resolution quantification of earthworm calcite granules from western European loess sequences reveals stadial–interstadial climatic variability during the Last Glacial Rhine loess at Schwalbenberg II – MIS 4 and 3 Flexible paleoclimate age-depth models using an autoregressive gamma process Stable isotopes reveal that the calciferous gland of earthworms is a CO2-fixing organ Chronometry of pedogenic and stratigraphic events from calcite produced by earthworms Experiments on the origin of 13C in the calcium carbonate granules produced by the earthworm Lumbricus terrestris Carbon isotope fractionation between amorphous calcium carbonate and calcite in earthworm-produced calcium carbonate Late Miocene climatic and environmental variations in northern Greece inferred from stable isotope compositions (delta O-18 Carbon isotope compositions of terrestrial C3 plants as indicators of (paleo)ecology and (paleo)climate Atmospheric CO2 effect on stable carbon isotope composition of terrestrial fossil archives Earthworm-produced calcite granules: A new terrestrial palaeothermometer A synthesis of clumped isotope data from Holocene soil carbonates Understanding recharge in soil-groundwater systems in high loess hills on the Loess Plateau using isotopic data Deuterium and oxygen-18 in European groundwaters-links to atmospheric circulation in the past Effects of climate on the active layer and permafrost on the North slope of Alaska Influence of seasonal snow cover on the ground thermal regime: An overview The thermal state of permafrost in the nordic area during the international polar year 2007–2009 Timing of massive ‘Fleuve Manche’ discharges over the last 350 kyr: Insights into the European ice-sheet oscillations and the European drainage network from MIS 10 to 2 The oxygen isotopic composition of seawater during the Last Glacial Maximum Sea level change through the last glacial cycle The 100,000-year ice-age cycle identified and found to lag temperature Vinnepand, M. et al. Combining inorganic and organic carbon stable isotope signatures in the Schwalbenberg Loess-Palaeosol-sequence near Remagen (Middle Rhine Valley, Germany). Front. Earth Sci. https://doi.org/10.3389/feart.2020.00276 (2020) Würmzeitliche Lößmollusken aus der Eifel (Universität Düsseldorf Climate reconstruction from pollen and δ13C using inverse vegetation modeling Monitoring of climate change in Germany – data products and services of Germany’s National Climate Data Centre Environmental inferences and chironomid-based temperature reconstructions from fragmentary records of the Weichselian Early Glacial and Pleniglacial periods in the Niederlausitz area (eastern Germany) Modest summer temperature variability during DO cycles in western Europe The Late Pleistocene Belotinac section (southern Serbia) at the southern limit of the European loess belt: Environmental and climate reconstruction using grain size and stable C and N isotopes Late Pleistocene climate evolution in Southeastern Europe recorded by soil bacterial membrane lipids in Serbian loess pedogenic and geogenic carbonate types from paleosol-loess sequence and their paleoenvironmental meaning Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from δ13C and δ18O of large mammal remains Terrestrial molluscan records of Weichselian Lower to Middle Pleniglacial climatic changes from the Nussloch loess series (Rhine Valley Widespread six degrees Celsius cooling on land during the Last Glacial Maximum Temperature reconstruction from 10 to 120 kyr b2k from the NGRIP ice core Regional atmospheric circulation over Europe during the last Glacial maximum and its links to precipitation Weichselian Upper Pleniglacial environmental variability in north-western Europe reconstructed from terrestrial mollusc faunas and its relationship with the presence/absence of human settlements The last Eurasian ice sheets - a chronological database and time-slice reconstruction The North Atlantic glacial eastern boundary current as a key driver for ice-sheet—AMOC interactions and climate instability The configuration of Northern Hemisphere ice sheets through the Quaternary The impact of the North American glacial topography on the evolution of the Eurasian ice sheet over the last glacial cycle Increased autumn and winter precipitation during the Last Glacial Maximum in the European Alps Dynamics of the North American ice sheet complex during its inception and build-up to the last glacial maximum Coupled atmosphere-ice-ocean dynamics in Dansgaard-Oeschger events Last Glacial Maximum ice sheet impacts on North Atlantic climate variability: The importance of the sea ice lid Linkage between dust cycle and loess of the Last Glacial Maximum in Europe Die altsteinzeitliche Fundstelle auf dem Schwalbenberg bei Remagen Berichte zur Archäologie an Mittelrhein und Mosel 4 Development of a semi-automated system for routine preparation of carbonate samples A gas ion source for radiocarbon measurements at 200kV ECHoMICADAS: A new compact AMS system to measuring 14C for Environment MICADAS: A new compact radiocarbon AMS system Discussion: Reporting and calibration of post-bomb 14C data The IntCal20 northern hemisphere radiocarbon age calibration curve (0–55cal kBP) The ERA-Interim reanalysis: Configuration and performance of the data assimilation system Pongratz, J., Reick, C. H., Raddatz, T. & Claussen, M. Effects of anthropogenic land cover change on the carbon cycle of the last millennium. Glob. Biogeochem. Cycles 23, GB4001 https://doi.org/10.1029/2009GB003488 (2009) Skill and reliability of climate model ensembles at the Last Glacial Maximum and mid-Holocene Insolation values for the climate of the last 10 million years Millennial-scale fluctuations of the European Ice Sheet at the end of the last glacial and their potential impact on global climate Download references This work was supported by the German Science Foundation (Deutsche Forschungsgemeinschaft DFG) in the framework of the TerraClime-Project (FI 1941/5-1; FI 1918/4-1; VO 938/25-1) awarded to P.F. and by an independent Max Planck Research Group awarded to K.E.F acknowledges support through the project PalMod funded by the German Federal Ministry of Education and Research (BMBF) We thank Sven Brömme for help in the stable isotope laboratory and Felix Hettwer for helping to extract the earthworm calcite granules We thank everyone who assisted with fieldwork in Remagen including Stefania Milano and Kristina Reetz We are grateful to the three reviewers for their comments that helped us to improve the scientific content of this work Present address: Institute of Earth Surface Dynamics Faculty of Geosciences and the Environment Research Group for Terrestrial Palaeoclimates MONREPOS Archaeological Research Centre and Museum for Human Behavioural Evolution Laboratoire des Sciences du Climat et de l’Environnement prepared the samples prior radiocarbon dating and C.H performed the analysis of wind and precipitation regime reconstructions interpretation of the results and writing of the manuscript The authors declare no competing interests Communications Earth & Environment thanks Thomas Stevens and the other reviewer(s) for their contribution to the peer review of this work Primary Handling Editors: Ola Kwiecien and Clare Davis Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s43247-022-00595-3 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Logging out of EU Login will log you out of any other services that use your EU Login account Use the CORDIS log out button to remain logged in on other services This is a machine translation provided by the European Commission’s eTranslation service to help you understand this page. Please read the conditions of use This website may no longer be available or may not contain the original content Please confirm that you want to visit {{ url }} New estimates of European sedimentary deposits suggest that Europe may have been the dustiest region on Earth about 21 500 years ago Permalink: https://cordis.europa.eu/article/id/429557-how-dusty-was-europe-during-the-coldest-periods-of-the-most-recent-ice-age Your booklet {{ title }} generated on {{ timestamp }} is available for download The file will remain available for {{ hours }} hours Integrating revolutionary technology from Leica Biosystems offers exceptionally high throughput and consistent staining quality to enhance efficiency and diagnostic confidence 2018 /PRNewswire/ -- Leica Biosystems today announced the global launch of the HistoCore SPECTRA Workstation which integrates the HistoCore SPECTRA ST stainer with the new HistoCore SPECTRA CV coverslipper for an all-in-one platform that enhances efficiency and diagnostic confidence for large-volume pathology labs by delivering exceptionally high throughput and consistent staining quality we turned to the HistoCore SPECTRA Workstation," said Christopher Hospidales Wisconsin Diagnostic Laboratories. "The HistoCore SPECTRA Workstation helps us to consistently provide the highest quality slides to our pathologist. It is important to know the staining quality of the first slide will be the very same on the 1600th slide.  It provides a level of confidence that we did not fully experience before." The HistoCore SPECTRA workstation is the first and only workstation with dual-glass coverslip lines enabling the highest throughput of up to 570 dried slides per hour The integrated coverslipper oven delivers unmatched glass-slide drying times of just 5-minutes providing immediately dry slides to pathologists for quicker diagnosis Lab managers appreciate the flexibility to run multiple protocols in parallel by processing H&E and special stains simultaneously increasing efficiency by 20 percent compared to other platforms RFID tracking of consumables further supports easy-to-manage staining "The next-generation HistoCore SPECTRA workstation is an innovative solution that standardizes several steps in the staining and coverslipping process for faster turnaround times and produces high-quality slides required by the pathologist," said Peter Reimer "This integrated system features unique coverslipper technology that streamlines the histology process supporting pathology labs that are challenged to meet the demands of increased workloads." Several advanced features reduce hands-on time for Histotechs RFID technology facilitates coverslipper autostart and displays the number of slides left to coverslip until exhaustion; the reagent management system's proprietary fill-level scan system ensures stain reproducibility; and the unique color-coded rack application starts individual protocols automatically when racks are inserted the coverslipper's unique broken-glass detector sensor removes and transfers broken coverslips for improved safety the HistoCore SPECTRA Workstation promises to enhance the quality the safety and the speed at which labs deliver diagnosable glass-coverslipped slides in today's demanding environment," said Reimer About Leica BiosystemsLeica Biosystems is a global leader in cancer diagnostics with the most comprehensive portfolio from biopsy to diagnosis Quality and Workflow Efficiencies to help advance diagnostic confidence Visit LeicaBiosystems.com for more information Media Contact: Courtney Hill, Global Brand Marketing Specialist Phone: 847-405-7041Email: [email protected] Photo - https://mma.prnewswire.com/media/745320/HistoCore_SPECTRA_Workstation_Leica_Biosystems.jpg http://www.LeicaBiosystems.com Media Contact: Courtney Hill, Global Brand Marketing Specialist Phone: 847-405-7041Email: LBS-GlobalMarketing@leicabiosystems.com Do not sell or share my personal information: Each instrument provides high quality sections and ease of use while delivering enhanced safety for the user "We are very excited to introduce the next generation of clinical microtomes based on our 145 years of experience in microtomy," stated Peter Reimer we have developed a family of microtomes that will help provide consistent quality and enhanced efficiency while maintaining a safe and healthy workplace for the user," said Reimer Mengia Berthold and Deputy Head of Laboratory "After using the HistoCore MULTICUT and AUTOCUT we noticed the stability of the instruments and high quality sectioning The new coarse feed wheels allows us to trim our blocks faster and the antistatic waste tray makes cleaning quick and easy Our lab techs immediately noticed the new product design and the larger surface top for storing tools and consumables." The HistoCore Rotary Microtomes deliver improved comfort through ergonomic positioning and adapting the coarse feed wheel to the user's preference helping reduce fatigue while trimming.  In addition the unique force balance system reduces the risk of injury from an unbalanced object head users can produce high quality paraffin sections for H&E a 2-in-1 blade holder provides the flexibility to use both high and low profile blades An optional antistatic waste tray increases efficiency by shortening cleaning time from minutes to seconds and reduces contamination to the user/environment by effectively collecting and containing waste a specimen cooling option allows for the block temperature to stay colder longer using the electrically cooled RM CoolClamp for standard cassettes The HistoCore Rotary Microtomes offer rapid specimen exchange with fast homing and programmable memo position (MULTICUT and AUTOCUT) and an electronic brake for safe blade and specimen handling (AUTOCUT) About Leica BiosystemsLeica Biosystems (LeicaBiosystems.com) is a global leader in workflow solutions and automation integrating each step in the workflow from biopsy to diagnosis.  Our mission of "Advancing Cancer Diagnostics Improving Lives" is at the heart of our corporate culture Our easy-to-use and consistently reliable offerings help improve workflow efficiency and diagnostic confidence Media Contact: Courtney Hill, Global Brand Marketing SpecialistPhone: +1.847.405.7041[email protected] Photo - https://mma.prnewswire.com/media/698683/Histore_Microtome_Clinical_Series.jpg https://www.leicabiosystems.com Media Contact: Courtney Hill, Global Brand Marketing SpecialistPhone: +1.847.405.7041LBS-GlobalMarketing@leicabiosystems.com 2024 (GLOBE NEWSWIRE) -- The Global Theranostics Market Size is to Grow from USD 1.9 Billion in 2023 to USD 3.3 Billion by 2033 at a Compound Annual Growth Rate (CAGR) of 5.68% during the projected period Get a Sample PDF Brochure: https://www.sphericalinsights.com/request-sample/4019 Theranostics is a type of pharmaceutical treatment used in combination with diagnostics to maximize efficacy It is the application of drugs in addition to diagnostic techniques Theranostics is the process of combining medicinal treatment and diagnostics to expedite the creation of more affordable and effective medications a quickly developing subject that the healthcare industry and regulatory organizations find intriguing A number of factors are driving the global theranostics market including the rising incidence of cancer globally and the resulting need for more specialized and potent therapies The identification of certain cancer biomarkers allows for the customization of treatment regimens for individual patients can lessen side effects and increase the efficacy of cancer therapies Browse key industry insights spread across 200 pages with 120 Market data tables and figures & charts from the report on the "Global Theranostics Market Size Buy Now Full Report: https://www.sphericalinsights.com/checkout/4019 The oncology segment is expected to hold the largest share of the global theranostics market during the predicted timeframe.The theranostics market is classified by disease into neurological disorders the oncology disorders segment is expected to hold the largest share of the global theranostics market during the predicted timeframe The growing number of cancer patients globally has led to the development of a method based on theranostic nanoparticles the mechanism combines prescription drugs with diagnostic techniques The specifically cancer-targeting medication-encapsulated nanoparticle-based treatment tracks and identifies biological systems The PCR segment is expected to hold the largest share of the global theranostics market during the forecast period the global theranostics market is divided into PCR the PCR segment is expected to hold the largest share of the global theranostics market during the forecast period Theranostics market growth is predicted to be driven by the creation and use of increasingly individualized medical solutions The growing prevalence of chronic illnesses and the growing need for specialized therapeutic and diagnostic options are projected to drive growth in the theranostics market over the coming years The hospitals and clinics segment is expected to hold the largest share of the global theranostics market during the forecast period the global theranostics market is divided into hospitals and clinics the hospitals and clinics segment is expected to hold the largest share of the global theranostics market during the forecast period The growing number of patients requiring diagnosis and treatment related to theranostics Theranostics market growth is predicted to be driven by the creation and application of increasingly individualized medical solutions Inquire Before Buying This Research Report: https://www.sphericalinsights.com/inquiry-before-buying/4019 North America is anticipated to hold the largest share of the global theranostics market over the predicted timeframe North America is anticipated to hold the largest share of the global Theranostics market over the predicted timeframe The primary forces driving the region's growth are the increasing prevalence of chronic illnesses and a growing demand for specialized medications Major industry players and the region's healthcare infrastructure are expected to keep driving market expansion Asia-Pacific is anticipated to develop at the quickest rate This is a result of companion diagnostics' growing acceptance and application particularly with regard to tumors in this region International businesses are also focusing a lot of effort on working together and building partnerships with local businesses which is expected to support Asia Pacific market development.Competitive Analysis: The report offers the appropriate analysis of the key organizations/companies involved within the global market along with a comparative evaluation primarily based on their product offering The report also provides an elaborative analysis focusing on the current news and developments of the companies This allows for the evaluation of the overall competition within the market Major vendors in the Global Theranostics Market include F Hoffman La Roche Get Discount At @ https://www.sphericalinsights.com/request-discount/4019   Market SegmentThis study forecasts revenue at global Spherical Insights has segmented the Global Theranostics Market based on the below-mentioned segments:  Global Electrical Stimulators Market Size, Share By Product (Transcutaneous Electrical Nerve Global Chronic Wound Care Market Size, Share By End User (Hospitals & Wound Clinics and Homecare Settings & Others) Global Generative artificial intelligence (AI) in healthcare Market Size, Share Patient Monitoring & Predictive Analytics Drug Discovery & Development and Others) Global Epilepsy Treatment Drugs Market Size, Share About the Spherical Insights & Consulting Spherical Insights & Consulting is a market research and consulting firm which provides actionable market research study quantitative forecasting and trends analysis provides forward-looking insight especially designed for decision makers and aids ROI Which is catering to different industry such as financial sectors The company's mission is to work with businesses to achieve business objectives and maintain strategic improvements For More Information on Your Target Market This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Tissue Processing Embedding Systems Market All 5 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Please upgrade your browser or activate Google Chrome Frame to improve your experience Friends may greet the family one hour prior to the service Interment will be at Graceland Cemetery with military honors accorded by area veteran’s organizations David Kent Simpson was born in Winona on Feb the son of Gerald and Helen (Nussloch) Simpson He grew up in Marshall and graduated from Marshall High School in 1959 After David graduated from optometry school in 1965 the couple settled in Albert Lea where David became a partner in the Albert Lea Optometric Clinic only the second optometrist from Minnesota to be commissioned and served as a Captain in Fort Campbell and David continued in private practice until 1990 joined the Albert Lea Regional Medical Group from 1990 to 1995 and finally retired with the Mayo Health System in 2004 He was extremely proud of his 40 year optometric career serving Albert Lea and the surrounding communities David was united in marriage with Ruth (Ubl) McCrea in New Ulm on June 15 and they continued to reside in Albert Lea while enjoying retirement David was a member of the First Presbyterian Church where he served as an elder He was a member of the American and Minnesota Optometric Associations he was awarded the Lion’s Club International Foundation’s highest honor which recognized his 45 years of commitment to humanitarian service and positive influence on his community He is also survived by Ruth’s children and grandchildren; daughter and grandchildren: Quinn and Ramsey of New Ulm; daughter and granddaughters: Abby and Savannah of New Ulm; daughter and grandchildren: Lillian and Stuart of Turlock He was preceded in death by his mother and father and wife Memorial contributions may go to Crossroads Hospice First Presbyterian Church or donor’s choice The Minnesota Timberwolves (33-29) are home in Northwest Division play versus the Utah Jazz (15-45) on Sunday which includes the Tampa Bay Lightning versus the Florida Panthers Top 25 teams will take the court across two games on Monday’s college basketball schedule The college basketball schedule on Monday should provide some fireworks Our computer model has provided picks against the… Ranked teams are on Monday’s college basketball schedule for two games including the Kansas Jayhawks squaring off against… The German junior riders team dominated the team championship test and won team gold at the 2007 European Junior Riders Championships in Nussloch Jill de Ridder won the class with 70.600 and would have placed much higher hadn't the Argentinian judge put on a pair of glasses De Ridder and Disco Boy scored in the low seventies with four judges but the judge at H ranked her 29th (!!!!!!) with 65% Remarkable is the progress the Italian teams have made winning both junior and young riders' bronze this year The judging at the 2007 European Junior and Young Riders Championships received incredible amounts of criticism It was astonishing how far off the judges were from each other parents and the audience was openly expressed with frequent booing and whistling to scores of some riders With a live score board it was easy to follow how judges gave a 7 to a German home favourite combination for a complete faulty series of tempi changes Zig Zag half passes with late flying changes received a score of 8 Italian riders were favoured by an Italian judge who gave a total score of 71% to a test with 5 major mistakes in it Eurodressage was flooded with emails from parents "how does it come that the sport is still judged so politically Trainers at the Championships said out load that the riders no longer believe in the credibility of the judges," a disgruntled parent told Eurodressage There were also complaints about the organisation of the show and the lack of perfection (German "grundlichkeit") was missing at the Nussloch Championships "we've been to three European Championships so far but I and I presume more participants are surprised that the FEI allows to organise a European Championship at this place There was so much mud everywhere." Fortunately for the show the weather was good during the weekend with sky high temperatures but the complaints did not stop with the footing The Netherlands and England got beautiful big stalls while the rest of the riders had to squeeze themselves into long tents with narrow corridors where manure piles were growing higher and higher as the competition progressed The arena was dragged 30 minutes before the competition and riders warming up had to ride round the tractor going through the ring 30 combinations had to ride in two warm up arena's in a time frame of 2 hours Riders could not practise their tempi changes on the diagonal It was a constant watching out for collisions The stewarding at the show was lamentable and only when a foreign judge made a comment about it a bit check was carried out after each ride!" reported on the website of the Danish Equestrian Federation that the judging at the European Championships was scandalous "We [the Danish youth riders] have ridden really well but never received the reward we should have got Especially Anna Kasprzak scored 70.10% in the team championship test one as fifth placed but the Italian judge placed her 13th!" Pedersen continued "Also Louise Mølby and Annmette Mortensen were scored down The Dutch were even surprised that they were better placed than the Danes but we have to look forward and see if in the future Denmark can have a judge at the show All photos copyrighted Barbara Schnell No Reproduction Allowed without Permission/Payment Back to the 2007 European Junior/Young Rider Championship Index The Portuguese Equestrian Federation has announced its junior and young riders team that will represent Portugal at the 2007 European Dressage Championship for Juniors and Young Riders in Nussloch The Portuguese Junior Riders team consists of: The Portuguese Young Riders Team consists of: All of them will be supported by their personal trainers and by the Chef d’Equipe who was the responsible for the selection of the best riders representing the Portuguese Federation "The presence of these riders proves the great effort these riders put into getting selected for the European Championship," Vania Ferreira of the Portuguese Dressage Association told Eurodressage "They are very young so they must manage both their riding careers with their responsibility for their school life 1×2 H2H Soccer Predictions