The man had argued and threatened a neighbor with a knife while they were on the stairs of the apartment building where the two lived shot dead a 26-year-old Afghan man in Schoenebeck The man had argued and threatened a neighbor with a knife while they were on the stairs of the apartment building where they lived the 26-year-old attempted to attack the officers who later died in hospital,” a police spokesperson said According to the German newspaper “Magdeburger Volksstimme,” the officers first fired three warning shots “The weapon was confiscated and the prosecutor’s office is investigating the exact circumstances that led the officer to shoot the 26-year-old,” the spokesperson said Read also other news on Nova News Click here and receive updates on WhatsApp Follow us on the social channels of Nova News on Twitter, LinkedIn, Instagram, Telegram ASHWAUBENON (WLUK) -- Amy Schoenebeck - a Certified Genetic Counselor at Aurora BayCare Medical Center - joined us at the FOX 11 Field House to talk about genetic testing Schoenebeck recommends that people with the following factors should consider genetic testing: Schoenebeck notes: "So the process (of genetic testing) is often a blood test And then essentially they're looking for a mistake - something in a gene that's increasing the risk for cancer It is not a guarantee that someone is going to get cancer - it's just increasing their risk and then we can be smarter .. what kind of extra screenings or risk reduction options are available Cause ideally we want to stop a cancer in the first place or find it as early as possible so we have the best outcome." When asked if it's important to talk to a genetic counselor before resting Schoenebeck responds: "I'm probably biased but I think yes Ideally we can go over the family history .. There are some very specific kinda national criteria Most insurance companies do cover genetic testing but often they follow those similar criteria and what would it mean for your family members So making sure you have the right information to share with them as well as the right health care team." To learn more about genetic testing at Aurora BayCare you can request an appointment with a cancer specialist by visiting AuroraBayCare.com/appointments Metrics details While the trans-isomer usually requires heating at approximately 200 °C to trigger thermal isomerization under racemization to cis-divinylcyclopropane which then undergoes facile Cope-type rearrangement the analogous contra-thermodynamic process is herein shown to proceed under Ni(I) metalloradical catalysis under mild conditions without any loss of stereochemical integrity enabling a mild and stereochemically pure access to seven-membered rings We herein disclose a metalloradical catalysis mode that is initiated by non-covalent interaction via π-coordination which leads to reactivity that is fundamentally in contrast to organic free radical reactivity and enables a reversible cis/trans-isomerization of vinylcyclopropanes under chiral inversion Our preliminary tests with a specific diphenyl substituted vinylcyclopropane indicated a partial isomerization instead of opening which fundamentally questions the validity of vinylcyclopropanes as mechanistic probes to test for metal-based radical intermediates neither the factors that dictate isomerization versus opening have been elucidated nor the wider scope and potential of this reactivity in synthesis We therefore set out to resolve these fundamental questions with a view to devise a selective and general isomerization for vinylcyclopropanes that proceeds without any loss of enantiopurity Selective stereoinversion of distal stereocentre Computational study of reaction pathway and orbital analysis of intermediate (Int2) Our closer inspection of the absolute stereochemistry of the product revealed that the carbon distal from the vinyl substituent was inverted selectively during isomerization, having generated (R,S)-trans-2 (Fig. 2a) Ni(I) therefore must have a profound effect on the overall reaction path in locking the stereocentre adjacent to the vinyl substituent while also influencing the overall driving force to favour the strained ring-closed product over ring-opened/rearranged products the lack of racemization observed under Ni(I)-catalysed isomerization (as opposed to thermal isomerization) means that although formally in both processes a homolytic scission of the central cyclopropane bond takes place the Ni-coordination locks one stereocentre through a π–allyl complex leaving only one centre to rotate (and invert) Another notable difference to organic free radical reactivity is that addition of an organic free radical both in terms of strain release and also the resonance delocalization gained through the aromatic substituent the radical is clearly more stabilized on the Ni-centre in the closed cyclopropane form in which the vinylcyclopropane serves predominantly as a π-ligand So called ‘radical clocks’ should hence be used with caution to test for the intermediacy of metal-based radicals the computed profile also suggests that the Ni(I)-bound cis- and trans-vinylcyclopropanes have only minute differences in energies which suggests full reversibility of the isomerization process The equilibrium is shifted ultimately through coordination/decoordination of the Ni(I) so as to reach the overall cis:trans ratio that reflects the inherent cis/trans preference of the substrate itself the observed ratio indeed matches the substrate’s free energy difference of the cis- and trans-isomer This suggests that the overall selectivity of the isomerization is readily predictable upon assessment of the inherent energy difference of the cis- and trans-isomer Our electron paramagnetic resonance (EPR) measurements of 3 itself in dioxane or with added cis-2 substrate gave distinct signals characteristic of the intermediacy of a metal-based radical While the Ni(I) dimer 1 in dioxane is EPR silent consistent with its dimeric low-spin configuration the EPR spectrum showed a distinct signal characteristic of a metal-based radical which would be in line with our above calculations and proposed pathway To test the wider synthetic potential of the isomerization we set out to examine alternative vinylcyclopropane motifs Variation of the aromatic-substituents had no marked impact; isomerization was equally rapid (5 min yielding approximately 90:10 trans:cis selectivity with 82–98% yield with methoxy (2) alkyl (5–6) or trifluoromethyl-substitution (7) as well as heterocyclic motifs such as a benzofuran-substituted vinylcyclopropane (9) The same final cis:trans ratio resulted irrespective of whether the exclusive cis-isomer or a cis/trans mixture was subjected to isomerization vinylcyclopropyl ketones (aromatic and aliphatic amides (21–22) as well as Weinreb amides (23) also isomerized efficiently to the corresponding trans-products in high selectivity and yield albeit under slightly longer reaction times of 15 min to 2 h at room temperature Even the free carboxylic acid was well tolerated and delivered 17 within 15 min at room temperature using 5 mol% of catalyst 1 purification was achieved by straightforward filtration we envisioned that the straightforward construction of these building blocks as cis/trans mixtures followed by Ni(I)-catalysed enrichment to the trans-isomer would be of value albeit under slightly more forced conditions (60 °C and/or extended reaction time) Capitalizing on the rich stereospecific diversification chemistry of the boronic ester unit can thus allow formation of substituted trans-vinylcyclopropanes with rests that might either be incompatible with Ni(I) catalysis or for which the inherent cis/trans stability difference of the substrate itself may not allow discrimination or induced selectivity in the reversible Ni(I)-catalysed isomerization process this is the case for alkyl substituted versions for which only bulky substituents (20) deliver high trans-thermodynamic preference and selectivity 35–36) and higher substitution at the cyclopropane ring (18 the starting material was fully recovered (27) The scalability of the process was next examined we employed 1 g of cyclopropane 16; since it is a liquid we omitted any solvent and attempted the isomerization of the neat compound adding solely 0.5 mol% of Ni(I) catalyst 1 a 92:8 trans:cis mixture of 16 was generated and isolated in 93% yield Neither additives nor solvent nor heating were necessary only minute amounts of the non-precious Ni(I) metalloradical was required and full atom-economy was retained in the process Scope of isomerization of internal alkenyl cyclopropanes To further harness the reversibility of the isomerization its unique capability to retain stereochemical information and its exceptional mildness we next considered to extend our studies to divinylcyclopropanes We considered the identified mechanistic features an ideal match to facilitate this strategic transformation as the reversible nature of the Ni(I)-based isomerization should cause any formed cis-1,2-divinylcyclopropane to undergo stereospecific Cope-type rearrangement and hence be removed from the equilibrium the first counter-thermodynamic trans-to-cis isomerization of a divinylcyclopropane under retention of enantiopurity should result followed by Cope-type rearrangement to generate the enantiomerically pure product Enantiopure synthesis of (+)-dictyopterene C′ Loss of stereochemical information in thermal isomerization/Cope sequence Application to fused bicyclic scaffolds (c) and spirocycles (d) bDeprotection conditions: tetra-n-butylammonium fluoride (five equivalents) The same process was equally effective with a larger ring (47) or one containing heteroatoms (48–50) this report disclosed the distinct reactivity of a Ni(I)-metalloradical in contrast to organic free radicals or many closed-shell metal catalysts does not lead to ring opening of a (di)vinylcyclopropane under strain release but instead triggers its reversible isomerization under selective inversion of a single (stereo)centre under mild conditions In light of the pronounced prevalence of odd-oxidation states in non-precious metal species this study further manifests their potential to enhance the synthetic toolbox and to meet global demands for greater sustainability and lower energy usage in chemical processes The authors declare that the data supporting the findings of this study are available within the paper and its Supplementary Information in Transition Metal‐Catalyzed Carbene Transformations (eds Wang Catalytic cascade reactions by radical relay Carbene radicals in transition-metal-catalyzed reactions Calibration of a new horologery of fast radical clocks Ring-opening rates for ring- and α-alkyl-substituted cyclopropylcarbinyl radicals and for the bicyclo[2.1.0]pent-2-yl radical (eds) Radicals in Organic Synthesis (Wiley Recent applications of the divinylcyclopropane–cycloheptadiene rearrangement in organic synthesis Radical redox-relay catalysis: formal [3+2] cycloaddition of N-acylaziridines and alkenes Anti-Markovnikov alcohols via epoxide hydrogenation through cooperative catalysis Highly asymmetric intramolecular cyclopropanation of acceptor-substituted diazoacetates by Co(II)-based metalloradical catalysis: Iterative approach for development of new-generation catalysts Asymmetric radical bicyclization of allyl azidoformates via cobalt(II)-based metalloradical catalysis in Small Ring Compounds in Organic Synthesis VI (ed From discovery to application: 50 years of the vinylcyclopropane–cyclopentene rearrangement and its impact on the synthesis of natural products Asymmetric preparation of polysubstituted cyclopropanes based on direct functionalization of achiral three-membered carbocycles General cyclopropane assembly by enantioselective transfer of a redox-active carbene to aliphatic olefins Nucleophilic carbenes derived from dichloromethane Stereodivergent rhodium(III)-catalyzed cis-cyclopropanation enabled by multivariate optimization The racemization of trans-1,2-divinylcyclopropane Stereochemistry of the thermal isomerizations of trans-1-ethenyl-2-phenylcyclopropane to 4-phenylcyclopentene in Patai’s Chemistry of Functional Groups (ed Reversible homolysis of a carbon–carbon σ-bond enabled by complexation-induced bond-weakening Cyclopropane stereomutation catalyzed by one-electron oxidants Light-enabled deracemization of cyclopropanes by Al-salen photocatalysis Photochemically induced ring opening of spirocyclopropyl oxindoles: evidence for a triplet 1,3-diradical intermediate and deracemization by a chiral sensitizer Gold(III)-catalysed cis-to-trans cyclopropyl isomerization Stereoselective cis-vinylcyclopropanation via a gold(I)-catalyzed retro-Buchner reaction under mild conditions Synthesis of trienes by rhodium-catalyzed assembly and disassembly of non-acceptor cyclopropanes Rhodium(I) catalysis of vinylcyclopropane epimerization and ring cleavage rearrangements Highly active nickel catalysts for the isomerization of unactivated vinylcyclopropanes to cyclopentenes Catalytic C–C bond activations via oxidative addition to transition metals Transition metal chemistry of cyclopropenes and cyclopropanes Transition metal-catalyzed selective C-C bond cleavage of vinylcyclopropanes in cycloaddition reactions E-Olefins through intramolecular radical relocation Monomeric three-coordinate N-heterocyclic carbene nickel(I) complexes: synthesis and catalytic applications in cross-coupling reactions Mechanism of the Ni(0)-catalyzed vinylcyclopropane–cyclopentene rearrangement Comproportionation and disproportionation in nickel and copper complexes Enantiospecific sp2–sp3 coupling of secondary and tertiary boronic esters Tailor-made α-amino acids in the pharmaceutical industry: synthetic approaches to (1R,2S)-1-amino-2-vinylcyclopropane-1-carboxylic acid (vinyl-ACCA) Thermal rearrangement of functionalized 1,2-divinylcyclopropane systems A convenient synthesis of substituted 4-cyclohepten-1-ones Preparation and thermal rearrangement of trans-3-[1-methyl-2-(2-methyl-1-propenyl)cyclopropyl]-2-cyclohexen-1-one An efficient method for the annelative formation of functionalized cycloheptanes Download references We thank Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University the European Research Council (ERC-864849) the DFG (German Research Foundation) Cluster of Excellence 2186 (The Fuel Science Center; ID: 390919832) the German Merit Foundations (scholarship to M.M.) and the Fonds der Chemischen Industrie (Kekulé scholarship to T.M.K.) for funding Calculations were performed with computing resources granted by Jülich Aachen Research Alliance-High Performance Computing (JARA-HPC) from RWTH Aachen University under project no Bhaskar Mondal & Franziska Schoenebeck All authors analysed the data and contributed to the preparation of the manuscript The authors declare no competing interests Nature thanks the anonymous reviewers for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations This file contains Supplementary Sections 1–15 – see Contents page for details Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41586-024-07555-1 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Please enable JS and disable any ad blocker a former curator at the Milwaukee Public Museum and others collected these eggs from the 1870s into the early 1900s and habitat notes were recorded for most species Joseph's Provincial Convent and later pastor at St Joseph would be the best curators of the egg collection Joseph's Academy in 1923 and was cared for by Sister Mary Alexia Sister Alexia compiled a catalog of the egg collection from Schoenebeck's original notes Joseph's donated the egg collection and specimens of mounted birds to the Museum of Natural History in 1970 The eggs remained in their original cotton-filled boxes until 1995 when they were moved to the current exhibit.  These cases contain selected examples from a large historically significant pan-North American egg collection displaying 768 specimens The collection also includes examples from Africa This display consists of three newly constructed cases arranged by family and includes rare or extinct varieties such as Passenger Pigeon Associated specimens collected in concert with the eggs include complete nests and multiple mounted examples of the bird species themselves These specimens are curated for research within the Ornithological collection Back We are delighted to announce that the 2024 Thieme–IUPAC Prize has been awarded to Franziska Schoenebeck of RWTH Aachen University Professor Schoenebeck becomes the 16th recipient of the prize and joins a distinguished group of scientists whose research has had a major impact on the field of synthetic organic chemistry which is awarded every two years and includes an award of € 5000 will be presented to Franziska Schoenebeck at the ICOS-24 conference before her Thieme–IUPAC lecture Schoenebeck and look forward to hearing about the latest developments from her laboratories Franziska Schoenebeck is leading an internationally recognized research program at the interface of organic synthesis and physical organic chemistry and uniquely combines a cutting-edge synthetic organic chemistry program with state-of-the-art computational and mechanistic studies Her group has made pioneering contributions in diverse areas such as the use of organogermanes in synthesis and catalysis the development of efficient methods for the trifluoromethylation of nitrogen groups and the application of machine learning in the study and development of dinuclear metal complex catalysts Read more about her research At thieme.de, see original announcement | read more about the prize | check out previous winners < Originating Call for Nominations (1 Oct 2023) Announcement published in the July 2024 issue of Chem Int April 2025 update: The Prize will be presented to Franziska Schoenebeck at the ESOC 2025 before her award lecture The 23rd European Symposium on Organic Chemistry will be in Copenhagen Apply Now Schedule Sign Me Up Sarita Yardi Schoenebeck ’02 recently received a grant from the National Science Foundation to study how kids use social media—and how parents can prepare them for life online Currently an assistant professor in the School of Information at the University of Michigan the California native majored in computer engineering at Dartmouth where she earned women’s tennis First Team All-Ivy honors three times She earned a master’s from UC Berkeley and a PhD from Georgia Tech Schoenebeck ’02 spoke with From the GREEN about her work “We know to teach children to brush their teeth and eat healthfully but parents really don’t know how to teach online behavior I study whether parents’ anxieties match children’s actual online behaviors and design applications that help the whole family set expectations for social media use and communicate with your children about technology Do they understand the impact of what they’re sharing Join Instagram or Snapchat or other sites your kids use Everyone might agree not to use a cell phone at the dinner table—including Mom and Dad but even now he watches when I’m on my laptop Another research interest is what parents themselves are doing online—how are they moderating their own behavior “My favorite thing about Dartmouth was the people—friends I made in engineering and the tennis team absolutely transformed me in terms of showing me how to prioritize relationships and balance my career.” We inspire students to practice good global citizenship while strengthening their own communities Act Now Clem Schoenebeck saw his first granddaughter in her mother's arms shortly after she was born She and Kristen were staring into each other's eyes with such intensity a voice came to him in a transcendent moment of grace He was completely taken with mystery and wonder He was so moved he wrote a "letter of welcome" for his first grandchild encouraged him to write the letter on his best stationary and frame it as a gift for his daughter and she saw the possibilities of poetry in those written words Clem signed up for poetry workshops given by Lynn's Jeanette Maes one of his dental patients became significant in Schoenebeck's introduction to poetry Must walked him through the process of submitting his first poem for publication Clem was off and running with his new interest His education continues today with Claire Keyes professor emeritus of Salem State University she runs a monthly poetry salon in Abbot Public Library He has also been a long-time member of Swampscott’s monthly poetry group They have been supportive and very special friends to each other Clem has had poems published in nine or 10 different journals He has had four nominations for The Pushcart Prize in Poetry Encircle Publications puts out a highly respected journal in which most of his published poems appeared Encircle Publications also put out a collection of 100 of his poems: “Where the time went; poems at eighty.” This book was nominated for the Massachusetts Book Award for Poetry Schoenebeck's father immigrated to the Boston area from Germany in 1923 He found his way to Holy Trinity Church on Shawmut Avenue in Boston A priest from his hometown in Germany welcomed him and gave him a place to stay in exchange for his work as a custodian for the church Clem's father went to night school where he learned his new language where he learned to be a highly skilled machinist who was one of fourteen children of parents who also emigrated from Germany in 1903 Her oldest sister died in the Spanish Flu Epidemic of 1918 His father was hired to run the machine shop in the College of Mineral Sciences State and developed an outstanding reputation for building instruments for the scientists He taught Clem and his two younger brothers to be patient with any project they undertook His father's words echo today: "If it's worth doing Clem attended Penn State and joined the university’s track and cross country teams Bonnie also attended Penn State as a psychology major They were married during Clem's senior year at Tufts Dental School This was followed by a two-year stint in the Army Dental Corps at Fort Ord in California Upon completion of his military obligation He opened his family practice in Swampscott in 1966 he was invited into a highly-respected group practice in Lynn where he continued his work until his retirement 38 years later He considers himself fortunate to have worked with some of the most outstanding people in his profession Being invited to the Marblehead Writers’ Group opened Clem's imagination to a very meaningful event in his life he published "Dancing with Fireflies," a memoir about growing up with his schizophrenic mother He and his young brothers learned significant life lessons in trying to dance around the lengthening shadows of his mother's mental illness Poetry has been the gift that brought that awareness into full daylight Clem is grateful for the blessed life he enjoys Poetry has slowed him down in contemplation of words and what they mean Trying to keep the words "truthful" as Jeanette Maes reminded him LUXEMBURG (WLUK) --Luxemburg-Casco is playing in its first state championship football game after senior Trace Schoenebeck drilled a 24-yard field goal in the final seconds of a Division 4 Level 4 playoff win over Catholic Memorial It was the most important play in program history and has made the 2023 season unlike any other we won," Schoenebeck said as to what he was thinking before the kick "So right before the kick I kind of zoned out and everything went quiet in my head and I was focused I knew right away it was going in," said senior Max Ronsman "I was probably one of the first ones celebrating Funny thing about the game-winning kick is Ronsman was the holder He actually let go of the football before it was kicked it stayed upright andSchoenebeck did the rest "Let go of it really early right before he kicked it; hand was not on the ball and it was still standing up," Ronsman said That kick allowed L-C (12-1) to record its second straight "upset" of the postseason against a team in Catholic Memorial that was the favorite from the start of the season to win the state title.Schoenebeck's heroics followed a road win over Two Rivers The Spartans have showed they are a championship-caliber team and now face Lodi (13-0) in the D4 state title game Thursday at 7 p.m where they are probably viewed as the underdog again we've played some really tough teams and some tough adversity so I feel like we gave our best shot," coach Neil Seering said of the his team And now Luxemburg-Casco gets to play at Camp Randall Stadium with a seating capacity of more than 80,000 Seering has never patrolled the sidelines for a game at Camp Randall "I remember being there as a spectator but it will seem like nobody is there because it's so big and massive," he said it's kind of a 'Hoosiers' idea for me it's a night game at seven o'clock look at your fans and embrace that and then get ready to play some Spartan football." Win or lose Spartan football has made 2023 a season to remember Metrics details Cross-coupling is a catch-all term for reactions in which two prefunctionalized fragments — most often one halide or pseudohalide and one organometallic or organometalloid — are joined with the aid of a metal catalyst to form a new bond Palladium-catalysed cross-coupling reactions in particular have revolutionized synthetic chemistry These reactions are now such a well-established synthetic tool that it is difficult to imagine how we would synthesize many of the molecules of the modern world without them Franziska Schoenebeck and co-workers from RWTH Aachen University have added a new orthogonal cross-coupling reaction to the toolkit: gold-catalysed cross-couplings of aryl germanes with diazoarenes The work began with a detailed experimental and computational study of Pd-based chemistry This revealed a fundamental problem: the transmetalation reaction at typical Pd(II) intermediates was highly endergonic — there was no driving force for the reaction — and the transition state was prohibitively high unlike their homogeneous catalyst counterparts catalysed cross-coupling of germanes and did so in preference to silanes boronic acids or boronic esters,” says Schoenebeck This observation as well as detailed computational studies led to the conclusion that germanes react preferentially in electrophilic aromatic substitution-type processes “This explains why an electrophilic metal catalyst such as a cationic palladium nanoparticle was effective and led us to try coupling using a gold catalyst,” she continues Prices may be subject to local taxes which are calculated during checkout Sherborne, G. J. et al. Modular and selective arylation of aryl germanes (C–GeEt3) over C–Bpin, C–SiR3 and halogens enabled by light-activated gold catalysis. Angew. Chem. Int. Ed. https://doi.org/10.1002/anie.202005066 (2020) Gold-catalyzed C–H functionalization with aryl germanes Download references Nature Reviews Chemistry http://www.nature.com/natrevchem/ Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41570-020-0207-y actress Angelina Jolie shocked the world with her announcement she had a double mastectomy Her mother died of breast cancer in 2007 and Jolie carried a genetic mutation that put her at an increased risk for developing various cancers The procedure — and a subsequent ovary and a fallopian tube removal — were done to reduce her risk I remember being inspired by all of this for two reasons Jolie helped reignite a dialogue about a serious women's health issue that for so long had been taboo can be a powerful tool for those predisposed to the disease senior genetic counselor at Aurora BayCare Medical Center the process of genetic testing is one that should come with consideration as results could yield either good or bad news — although that perception varies from patient to patient.  "It's my job to basically lay out the positives and negatives and help people understand how this information can benefit their health," she said. "Regardless, I make sure they're comfortable with their choice." would I want to know if I had a gene that meant I was at a high risk for disease was one of Schoenebeck's first cardiology genetic counseling patients when the medical center began offering counseling to cardiology patients just last year. Guilfoyle is another example of a woman who despite facing tough circumstances, decided to dive into the unknown and take control of her health and future like never before.  Guilfoyle underwent genetic counseling in October to determine her risk for hypertrophic cardiomyopathy — a potentially deadly condition in which the heart muscle becomes abnormally thick making it harder for the heart to pump blood.  Guilfoyle said she sought out genetic counseling through guidance and support form her mother who revealed a number of family members had been diagnosed with the heart condition. Guilfoyle said the realization uncles and others endured things likes shortness of breath need for a pacemaker and even cardiac arrest.  After learning of Guilfoyle's family history and her desire to know her risk for the heart condition an interventional cardiologist at Aurora Baycare, ordered an echocardiograph and a blood test.  Guilfoyle's test results came back positive for the MYH7 gene which means there's a higher chance that she might someday be diagnosed with hypertrophic cardiomyopathy.  I was hoping there wasn't going to be a genetic mutation," she said "I'm going to say it was bittersweet Just having those results and knowing my identity in that sense I'm the owner and operator of my life and it might not come with a how-to manual The news wasn't what she wanted to hear, but the good thing is she didn't have to change much about her lifestyle.  massage therapist and lover of the performing arts avoiding stress and maintaining a healthy blood pressure If a patient is diagnosed with the condition could require surgery or a heart transplant Whatever the future holds, Guilfoyle said, "I am not going to dwell on this hurdle."  back to the question: If my family members were diagnosed with a disease would I want to know if I had a genetic mutation that predisposes me to it The benefits of knowing seem to outweigh the bad news factor The scenarios are either I learn I don't have a mutation, I learn I do and take it in stride or the diagnosis is devastating and drastically alters the rest of my life.  The truth is, I don't know what I'd do. And I'll likely never know what I'd do unless I'm actually put in this situation. But this is exactly why genetic counselors exist — to help all kinds of patients make important decisions just like Guilfoyle did.  GREEN BAY – It’s been 48 years since a Green Bay East football team had an undefeated season Members of the 1969 team who accomplished the feat gathered on Friday at the Rite Place for a long overdue reunion The group went 8-0 that season and finished as the third-ranked team in the state while playing for legendary coach Gene Bray “I think you kind of reach a point where people are starting to retire and you reflect on those fun years those special years,” said Dennis Schoenebeck “Although it was only an eight-game season the Red Devils didn’t have a bunch of big-name players that season despite their lofty ranking who went on to play tight end at Illinois and now is the CEO of Global Benefits Group Insurance in California But what the Red Devils did have was a nasty defense After beating rival Green Bay West in a season opener – it was the first time in the historic series the teams met in September – East put together five straight shutouts on its way to a perfect season Schoenebeck was on a defensive line that included Bruce Steinfeldt Ken Kox and Steve Schuh were the team’s top linebackers while Dubrish led a secondary that included Steve Keuler “We had a very special group of guys that were talented but also it was probably the most unselfish group of guys I ever played with,” said Steinfeldt who played one season at the University of Wisconsin-La Crosse and worked in the press room at the Green Bay Press-Gazette for 26 years some of the Red Devils always have wondered what could have been during an era when there was no postseason play The WIAA didn’t sponsor a state football playoff program until 1976 East didn’t get an opportunity to face top-ranked Fond du Lac or second-ranked Antigo East and Fond du Lac shared the Fox River Valley Conference title in the 12-team league “We just felt we got robbed,” Steinfeldt said “The one year we didn’t play Fond du Lac.” Fond du Lac had several standout players that season including a handful who earned Division I scholarships “We would have liked to play them to see what happens,” said kicker and offensive lineman Bob DeKeyser “Our mindset was that we would beat them You just couldn’t think any other way.” Although there was no state championship to celebrate there is a certain amount of pride still felt for what the team helped start That squad started a run of 30 wins in 35 games the next four seasons and put Bray on his eventual path to the Wisconsin High School Football Coaches Association Hall of Fame in 1989 Bray coached at East from 1967 to 1982 and went 87-48-3 while leading the Red Devils to six FRVC titles “We had something going on there that was a little bit special,” DeKeyser said “We always felt that the ’69 class was Bray’s only undefeated team and we kind of felt that maybe our class was the class that started that era of really good East football." There also can be pride that so many of the players did well after high school some of which can be attributed to Bray and a coaching staff that included Robert Boyle Schoenebeck came from a single-parent family and wasn’t sure what he should do with his life after high school Bray approached him and told his pupil he expected him to attend college Those few words gave Schoenebeck the encouragement to move in that direction He retired in January 2016 after serving as the CEO of the Greater Wichita YMCA in Kansas for 25 years “I have to credit him for going to school,” Schoenebeck said of Bray DeKeyser also wasn’t sure if he wanted to attend college He had a summer job with Schreiber at the time But the coaching staff sat him down and asked about his classes Boyle took him out of practice and brought him to the guidance office to fill out a scholarship form DeKeyser was a standout kicker at UW-Platteville because that’s where Bray urged him to go He ended up setting every kicking record in the program’s book earned a Master’s degree and was a school counselor until retiring 10 years ago at 55 Norbert the past 19 seasons and also had coaching stints at Platteville and in the high school ranks at Niagara “How much more of a defining role can someone have on your life?” DeKeyser said of his coaches there is a lot of opportunities to go astray all those kinds of guys were there to grab you by the ear and say ‘This is what you are going to do.’ I know they did that for a lot of guys “So much of my life would have been different without those guys.” Swampscott resident Clem Schoenebeck will be at the Swampscott Public Library on Thursday He will be reading excerpts from his book “Where the Time Went: Poems at Eighty.” The book was recently nominated for the Massachusetts Book Award for Poetry and the Foreword INDIES Book of the Year Award Schoenebeck will read his poem “Flight,” which is dedicated to Jennifer Harris a Swampscott resident who died in service to her country A copy of it will be framed and hung near Jennifer’s portrait in the library’s Harris Room Registration for this event will begin on Monday Please register from the library website at www.swampscottlibrary.org A bright blue swimming pool stands out amid murky floodwater from the River Elbe which swamped this garden near the German city of Magdeburg during floods that swept through a huge area of Europe The deluge forced thousands of people to flee their homes in Germany the Czech Republic and Hungary and caused billions of dollars of damage A man inspects a sandbag wall near the River Elbe in the eastern German town of Schoenebeck Flooded railway tracks are pictured near the River Elbe in the eastern German town of Schoenebeck A dead deer hangs on a fence along the flooded A3 motorway near Deggendorf A car drives away from a small settlement flooded by the River Danube near Deggendorf Volunteers relax on a wall of sandbags put up to contain damage caused by flooding in Dresden Two men paddle their boat into the entrance of a flooded house A brand new Jaguar F-Type convertible stands in a showroom covered with a thin film of mud following the deluge The statue of world harmony leader Sri Chinmoy is partially submerged by the rising Vltava River A man checks the water level of the swollen Vltava River Firemen pump water out of a flooded field near the city of Melnik People walk over Radobyl Hill to look at an area flooded by the swollen Labe (Elbe) River A girl from the village of Mlekojedy stands with her dog in front of the flooded road to her home Firefighters evacuate a woman from her house in the southern Bohemian village of Nemcicky Vaclav Reichl dries out his family photographs The door of a house is almost totally submerged in the village of Lounky Waters overflow from the River Danube in Bratislava A man in a boat floats along a street flooded by the River Danube in Klosterneuburg Gravestones are partially submerged by flood water at a cemetery in Schaerding A church stands partially underwater in Marbach A priest leaves a church with sandbags arranged around the entrance in Budapest A ticket booth for cruise ships stands mostly underwater along the banks of the flooding River Danube Houses near the Hungarian town of Nagymaros are surrounded by floodwater from the River Danube Before: A man sweeps steps by the banks of the River Danube before it flooded in Budapest.After: A few days later Before: People walk along the edge of the swollen Vltava River in Prague.After: Twenty-four hours later Before: Water floods a soccer field south of the Bavarian city of Deggendorf.After: The same field is seen after the deluge receded By Donna Lu French bulldogs can have breathing problems Many English and French bulldogs develop breathing difficulties and the flat faces of these breeds have long been thought to be responsible but now a gene mutation in these dogs suggests that face shape isn’t the only culprit Jeffrey Schoenebeck at the University of Edinburgh and his colleagues have found a mutation in a gene called ADAMTS3 Norwich terriers often suffer from similar breathing problems even though they have proportional noses The team analysed DNA from more than 400 Norwich terriers