The Porzellangässchen, or "Porcelain Alley," in Selb, Germany is a distinctive pedestrian passageway showcasing porcelain mosaics that line the pavement and walls it was revamped in 2003 by artist Barbara Flügel She used around 55,000 porcelain tiles to create intricate patterns along the alley making it a unique tribute to Selb's long history as a center of porcelain production The alley connects Ludwigstraße with Gerberplatz immersive experience that celebrates Selb's cultural and artistic heritage in porcelain you can explore additional details on local tourism sites or visit in person to experience this unique artistic installation Baltasar Bachero became a hero after he saved the lives of two children nearly run over by an out-of-control mule-drawn carriage This massive 286,200-tile mosaic was the largest mural of its kind in the United States and is an early example of computer-generated art The only museum dedicated to the tile production for which the Rupel region was renowned An intricate ceramic tile facade adorns this five-star hotel these colorful tiles advertise a long-defunct range of purgative teas These mosaic designs promise a cure for headaches This artist's studio is decorated inside and out with tiles Metrics details selenocysteine (Sec) is delivered to the ribosome by selenocysteine-specific tRNA (tRNASec) with the help of a specialized translation factor Sec-tRNASec recodes a UGA stop codon next to a downstream mRNA stem–loop Here we present the structures of six intermediates on the pathway of UGA recoding in Escherichia coli by single-particle cryo-electron microscopy The structures explain the specificity of Sec-tRNASec binding by SelB and show large-scale rearrangements of Sec-tRNASec Upon initial binding of SelB–Sec-tRNASec to the ribosome and codon reading the 30S subunit adopts an open conformation with Sec-tRNASec covering the sarcin–ricin loop (SRL) on the 50S subunit Subsequent codon recognition results in a local closure of the decoding site which moves Sec-tRNASec away from the SRL and triggers a global closure of the 30S subunit shoulder domain These results reveal how codon recognition triggers GTPase activation in translational GTPases Prices may be subject to local taxes which are calculated during checkout Biosynthesis of selenoproteins—an overview Protein factors mediating selenoprotein synthesis Crystal structure of active elongation factor Tu reveals major domain rearrangements Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine Tertiary structure of bacterial selenocysteine tRNA Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine Crystal structure of the full-length bacterial selenocysteine-specific elongation factor SelB Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors Domain structure of the prokaryotic selenocysteine-specific elongation factor SelB The crystal structure of Cys–tRNACys–EF-Tu–GDPNP reveals general and specific features in the ternary complex and in tRNA Selenocysteine incorporation machinery and the role of selenoproteins in development and health Recognition of the mRNA selenocysteine insertion sequence by the specialized translational elongation factor SELB Interaction of tRNA with 23S rRNA in the ribosomal A Interaction of a selenocysteine-incorporating tRNA with elongation factor Tu from E.coli Antideterminants present in minihelix(Sec) hinder its recognition by prokaryotic elongation factor Tu The interface between Escherichia coli elongation factor Tu and aminoacyl-tRNA Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis The tRNA specificity of Thermus thermophilus EF-Tu Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome Coding from a distance: dissection of the mRNA determinants required for the incorporation of selenocysteine into protein Partitioning between recoding and termination at a stop codon-selenocysteine insertion sequence Evolutionary optimization of speed and accuracy of decoding on the ribosome The reaction of ribosomes with elongation factor Tu.GTP complexes Aminoacyl-tRNA-independent reactions in the elongation cycle determine the accuracy of protein synthesis Is there proofreading during polypeptide synthesis Selection of tRNA by the ribosome requires a transition from an open to a closed form Recognition of cognate transfer RNA by the 30S ribosomal subunit Structures of the bacterial ribosome in classical and hybrid states of tRNA binding Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy The mechanism for activation of GTP hydrolysis on the ribosome Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome An active role for tRNA in decoding beyond codon:anticodon pairing How mutations in tRNA distant from the anticodon affect the fidelity of decoding Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA Inhibition of selenoprotein synthesis by selenocysteine tRNA[Ser]Sec lacking isopentenyladenosine Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome Ribosome-induced tuning of GTP hydrolysis by a translational GTPase Dual use of GTP hydrolysis by elongation factor G on the ribosome Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome Energetics of activation of GTP hydrolysis on the ribosome Elongation factor G bound to the ribosome in an intermediate state of translocation Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome and FRET in studies of initiation of translation in bacteria GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs Purification and characterization of hexahistidine-tagged elongation factor SelB Thermodynamics of the GTP-GDP-operated conformational switch of selenocysteine-specific translation factor SelB Selenoprotein biosynthesis: purification and assay of components involved in selenocysteine biosynthesis and insertion in Escherichia coli Single-step purification of specific tRNAs by hydrophobic tagging Towards understanding selenocysteine incorporation into bacterial proteins Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions Transient conformational states of aminoacyl-tRNA during ribosome binding catalyzed by elongation factor Tu Kinetic determinants of high-fidelity tRNA discrimination on the ribosome coli ribosome-EF-Tu complex at &lt;3 Å resolution by Cs-corrected cryo-EM Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex RELION: implementation of a Bayesian approach to cryo-EM structure determination High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy Quantifying the local resolution of cryo-EM density maps UCSF Chimera--a visualization system for exploratory research and analysis Software for handling macromolecular envelopes Version 1.2 of the Crystallography and NMR system Crystallography & NMR system: A new software suite for macromolecular structure determination PHENIX: a comprehensive Python-based system for macromolecular structure solution Improved molecular replacement by density- and energy-guided protein structure optimization Refinement of protein structures into low-resolution density maps using rosetta The HHpred interactive server for protein homology detection and structure prediction Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB Semiautomated model building for RNA crystallography using a directed rotameric approach Correcting pervasive errors in RNA crystallography through enumerative structure prediction Computational Crystallography Newsletter 43–44 (2013) Linking crystallographic model and data quality Overview of the CCP4 suite and current developments Energy barriers and driving forces in tRNA translocation through the ribosome GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit Improved side-chain torsion potentials for the Amber ff99SB protein force field The missing term in effective pair potentials Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations AMBER Force Field Parameters for the Naturally Occurring Modified Nucleosides in RNA Automatic atom type and bond type perception in molecular mechanical calculations Is the sequence-specific binding of aminoacyl-tRNAs by EF-Tu universal among bacteria Engineering the elongation factor Tu for efficient selenoprotein synthesis Decameric SelA•tRNA(Sec) ring structure reveals mechanism of bacterial selenocysteine formation Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement A ratchet-like inter-subunit reorganization of the ribosome during translocation Download references Zimmermann for expert technical assistance and M Koske for support in high-performance computation The work was supported by the Deutsche Forschungsgemeinschaft Grant FOR 1805 (to H.S. and H.G.) and by the Sonderforschungsbereich 860 (to R.F.) Present address: †Present addresses: Molecular and Radiation Biophysics Department Konstantinov Petersburg Nuclear Physics Institute of National Research Centre ‘Kurchatov Institute’ A.L.K.); St Petersburg Polytechnic University Max Planck Institute for Biophysical Chemistry Department of Molecular Structural Biology Department of Theoretical and Computational Biophysics performed cryo-EM experiments and data analysis and drafted the paper built atomic models and performed pseudo-crystallographic refinement performed and analyzed molecular dynamics simulations and A.L.K prepared ribosome complexes for cryo-EM finalized the paper with inputs from all authors The authors declare no competing financial interests Yokoyama for their contribution to the peer review of this work supervised classification by projection matching; ‘bad’ 70S the particles of low quality and/or those showing mixtures of different compositions and conformations; initial complex (hybrid) (IC (hybrid)) ratcheted state of the ribosome with one tRNA in the hybrid state Mask used for focused classification in step 4 Cryo-EM reconstruction from 100,000 random unsorted particle images initial refinement stage at 10 Å resolution showing only scattered density (red) for SelB Structural changes resolved by computational sorting as quantified by the r.m.s.d and the changes in mass due to ligand binding and dissociation wh4 and SECIS of the GTPase-activated state Top right: Sec-tRNASec density (purple) in the initial binding state at 5.3 Å resolution; the conformation of the invariant histidine 61 is not discernible (question mark) Middle right: Density for histidine 61 (blue) in the codon reading state indicating a partially flipped-in conformation Densities for rRNA modifications as seen in the GTPase-activated state at 3.4 Å resolution Arrows denote the characteristic distortion of the nucleobase of D2449 and methyl groups for the other modified nucleotides Cryo-EM reconstructions of the individual states (as indicated) coloured according to local resolution Heat maps are adjusted to the respective resolutions ranges of the cryo-EM maps in f and g The arrow denotes the substantially lower local resolution of SelB residues 485 to 614 in the GTPase-activated state; atomic models for such regions were correspondingly refined at lower resolution (Methods) does not require any changes during translation elongation Interaction of SelB domain 4 with the shoulder of the 30S subunit Winged-helix motif 4 (wh4) of SelB forms salt bridges with protein S4 while wh2 and wh3 embrace helix 16 of 16S rRNA by interacting mainly with the rRNA backbone Concentration dependence of the apparent rate of GTP hydrolysis by SelB measured with increasing concentrations of ribosomes programmed with mRNAs ‘UGA’ (black) mRNA construct ‘UGA’ used for structural and kinetic analyses containing the cognate UGA codon coding for Sec and the functional minimal fdhF-SECIS The Sec codon and the essential bases of the SECIS are indicated by boxes; SD mRNA constructs ‘iSECIS’ and ‘UUC’ used for kinetic analysis Changes in comparison to the ‘UGA’ mRNA are indicated in blue (iSECIS) and red (UUC) Deviations of the 16S rRNA backbone phosphates in the initial binding or GTPase-activated states from the initial complex superimposed on 23S rRNA (top) or 16S rRNA (bottom) Negative values correspond to the 30S domain opening Landmarks of the 30S subunit are indicated Experimental densities of the decoding centre region rendered at 2–2.5σ densities for tRNASec were omitted for the GTPase-activated state Anti-conformation of G530 and stacking interaction with C518 of 16S rRNA as seen in the different states Bottom left: Note the density of tRNASec (purple) suggesting a partial interaction of U34 with the mRNA codon in the codon reading state A1493 (red) of 16S rRNA and A1913 (slate blue) of 23S rRNA Top left: In the initial complex the reduced densities for the three nucleotides indicate a dynamic equilibrium between two states: (1) A1492 red) with A1913 in anti-configuration (‘anti’ dark red) with A1913 in syn-configuration (‘syn’ Top middle: The dynamic nucleotides in the initial complex are discernible at lower threshold (red mesh Top right and bottom left: Density in the initial binding and codon reading states is compatible with the bases of A1492 and A1493 flipped-in and A1913 in the anti-configuration Bottom right: In the GTPase-activated state A1492 and A1493 are flipped-out and A1913 remains in the anti-conformation Density for the codon–anticodon interaction in the GTPase-activated state rendered at ~3σ which suggests that there is no direct coupling between tRNA dynamics and SelB motions on the ribosome Download citation Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article the UGA stop codon is recoded using the specialized amino acid selenocysteine (Sec) The recoding process also requires the SelB GTPase Holger Stark and colleagues have solved multiple structures of the Escherichia coli ribosome bound to Sec-tRNASec and SelB to understand how SelB interacts with the tRNA and how this complex reorders both the small and large subunits of the ribosome upon binding The way in which these events at the codon activate the GTPase is revealed Sign up for the Nature Briefing newsletter — what matters in science Next-generation IgG protease candidate Xork to be licensed for development with AT845 an investigational Astellas Gene Therapies' product Selecta to receive a $10M upfront payment and eligible to receive up to $340M for certain additional development and commercial milestones plus royalties on commercial sales WATERTOWN, Mass. and TOKYO, Jan. 9, 2023 /PRNewswire/ -- Selecta Biosciences, Inc. (NASDAQ: SELB "Astellas" or "Astellas Gene Therapies") today announced an exclusive licensing and development agreement for IdeXork (Xork) Xork is being studied as a potential next generation immunoglobulin G (IgG) protease that will be developed by Astellas for use with AT845 adeno-associated virus (AAV)-based treatment for Late-Onset Pompe disease (LOPD) in adults "Currently many patients are ineligible for clinical trials with investigational AAV gene therapy products due to the presence of naturally occurring antibodies against AAV gene therapy capsids," said Carsten Brunn President and Chief Executive Officer of Selecta "Xork has the potential to expand access to life-changing gene therapies by addressing pre-existing immunity to AAV Most other IgG proteases in development are derived from common human pathogens and as a result there is a high prevalence of pre-existing antibodies against these proteases that can restrict their use Xork is differentiated by its low cross-reactivity to pre-existing antibodies in human serum We are thrilled to partner with Astellas as they advance their robust gene therapy portfolio through the clinic." "We are looking forward to partnering with Selecta as we strive to expand our therapies to a broader range of patients living with debilitating diseases This agreement provides an opportunity to deliver potentially transformative gene therapy treatments to a specific population of LOPD adult patients who might otherwise be ineligible for clinical trials or treatment with Astellas' investigational product." Selecta will receive a $10M upfront payment and is eligible to receive up to $340M for certain additional development and commercial milestones plus royalties on any potential commercial sales where Xork is used as a pre-treatment for AT845 Selecta is responsible for the development and manufacturing of Xork and will maintain the rights for the development of additional indications beyond Pompe disease Astellas would have the sole and exclusive right to commercialize Xork for use in Pompe disease with an Astellas gene therapy investigational or authorized product About AT845 for the treatment of Late-Onset Pompe Disease (LOPD) Astellas is developing AT845 a novel gene replacement therapy using an AAV8 vector under a muscle-specific promotor to deliver a functional copy of the GAA gene AT845 is being investigated to determine whether it can deliver a functional GAA gene that is efficiently transduced to express GAA directly in tissues affected by the disease About Astellas Gene TherapiesAstellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines with the potential to deliver transformative value for patients Our gene therapy drug discovery engine is built around innovative science and industry leading internal manufacturing capability with a particular focus on rare diseases of the eye Astellas Gene Therapies will also be advancing additional Astellas gene therapy programs toward clinical investigation Astellas Gene Therapies is based in San Francisco with manufacturing and laboratory facilities in South San Francisco Astellas Cautionary NotesIn this press release statements made with respect to current plans strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas These statements are based on management's current assumptions and beliefs in light of the information currently available to it and involve known and unknown risks and uncertainties A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements but are not limited to: (i) changes in general economic conditions and in laws and regulations (iv) the inability of Astellas to market existing and new products effectively (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets and (vi) infringements of Astellas' intellectual property rights by third parties Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice Selecta Forward-Looking StatementsAny statements in this press release about the future expectations plans and prospects of Selecta Biosciences statements regarding  the unique proprietary technology platform of the Company and its partners,the anticipated benefits of the Company's licensing and development agreement with Astellas related to Xork the potential of ImmTOR to enable re-dosing of AAV gene therapy and to mitigate immunogenicity the potential of ImmTOR and the Company's product pipeline to treat chronic refractory gout the anticipated timing or the outcome of ongoing and planned clinical trials the anticipated timing or the outcome of the FDA's review of the Company's regulatory filings the Company's and its partners' ability to conduct its and their clinical trials and preclinical studies the timing or making of any regulatory filings the anticipated timing or outcome of selection of developmental product candidates the potential treatment applications of product candidates utilizing the ImmTOR platform in areas such as gene therapy the ability of the Company and its partners where applicable to develop gene therapy products using ImmTOR the novelty of treatment paradigms that the Company is able to develop whether the observations made in non-human study subjects will translate to studies performed with human beings the potential of any therapies developed by the Company to fulfill unmet medical needs the Company's plan to apply its ImmTOR technology platform to a range of biologics for rare and orphan genetic diseases the potential of the Company's technology to enable repeat administration in gene therapy product candidates and products the ability to re-dose patients and the potential of ImmTOR to allow for re-dosing the ability to restore transgene expression the potential of the ImmTOR technology platform generally and the Company's ability to grow its strategic partnerships and enrollment in the Company's clinical trials and other statements containing the words "anticipate," "believe," "continue," "could," "estimate," "expect," "hypothesize," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "would," and similar expressions constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors the following: the uncertainties inherent in the initiation completion and cost of clinical trials including proof of concept trials the availability and timing of data from ongoing and future clinical trials and the results of such trials whether preliminary results from a particular clinical trial will be predictive of the final results of that trial and whether results of early clinical trials will be indicative of the results of later clinical trials the ability to predict results of studies performed on human beings based on results of studies performed on non-human subjects the unproven approach of the Company's ImmTOR technology potential delays in enrollment of patients undesirable side effects of the Company's product candidates its reliance on third parties to manufacture its product candidates and to conduct its clinical trials the Company's inability to maintain its existing or future collaborations its inability to protect its proprietary technology and intellectual property the availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements the Company's recurring losses from operations and negative cash flows substantial fluctuation in the price of the Company's common stock risks related to geopolitical conflicts and pandemics and other important factors discussed in the "Risk Factors" section of the Company's most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q and in other filings that the Company makes with the Securities and Exchange Commission any forward-looking statements included in this press release represent the Company's views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date The Company specifically disclaims any intention to update any forward-looking statements included in this press release maker of IZERVAY™ (avacincaptad pegol intravitreal solution) "Astellas") and YASKAWA Electric Corporation (TSE: 6506 Health Care & Hospitals Medical Pharmaceuticals Biotechnology Pharmaceuticals Do not sell or share my personal information: .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By South Jersey TimesTo the Editor: stop and think: Why is an extreme amount of money being spent on repetitive TV ads and mailers a Republican Gloucester County freeholder board candidate integrity and dedication to public service and will bring out the true reasons for rising taxes As a former police officer with more than 28 years of service he was recognized as New Jersey DARE Officer of the Year in 2011 He was a drug-education instructor in the schools and a mentor for other officers throughout the state made arrests and fought to make sure that the victims were not forgotten 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All rights reserved (About Us) The material on this site may not be reproduced except with the prior written permission of Advance Local Community Rules apply to all content you upload or otherwise submit to this site YouTube's privacy policy is available here and YouTube's terms of service is available here Ad Choices Archive Architecture The children’s daycare center (Haus der Tagesmütter) is the first building in an ensemble of four that are going up in the German city of Selb as a result of the international competition Europan 9, held in the year 2008. It forms part of a larger urban strategy to reactivate Selb through a series of small projects catering to young citizens, and in the manner of ‘preventive acupuncture’, particularly the urban core. Centro de día para niños (Haus des Tagesmütter) Childminders Center in Selb, Germany. Gutiérrez-de la Fuente Arquitectos + TallerDE2 Arquitectos / Natalia Gutiérrez y Julio de la Fuente; Arantza Ozaeta y Álvaro M. Fidalgo. SelbWERK (arquitectos técnicos quantity surveyors); Ingenieurbüro Schultheiß-Dietel (estructuras structural engineering); Ingenieurbüro Peter Möller (instalaciones MEP consultant). Sorry, there arent any match using your search terms, please try again using other terms. Volume 13 - 2022 | https://doi.org/10.3389/fpsyg.2022.928189 The SSIS SEL Brief Scales (SSIS SELb) are multi-informant (teacher and student) measures that were developed to efficiently assess the SEL competencies of school-age youth in the United States the SSIS SELb was translated into multiple languages for use in a multi-site study across six European countries (Croatia The purpose of the current study was to examine concurrent and predictive evidence for the SEL Composite scores from the translated versions of the SSIS SELb Scales Results indicated that SSIS SELb Composite scores demonstrated expected positive concurrent and predictive relationships with scores from the Connor-Davidson Resilience Scale (CD-RISC) and negative relationships with scores from the problem behavior scales of the Strengths and Difficulties Questionnaire (SDQ) these patterns generally were consistent across informants (parents and students) and samples providing initial validity evidence for the Composite score from the translated versions of the SSIS SELb Scales Limitations and future research directions are discussed Considering the linguistic diversity present in Europe many countries simply do not have access to validated translations of high-quality SEL measures an adolescent self-report measure of resilience Although comprehensive programs have been developed to promote SEL across schools in Europe, there is a lack of assessment compendia that recommend instruments to measure SEL, due in part to the scarcity of available measures intended for use across multiple countries. Cefai et al. (2021) recommended that SEL assessments be multi-modal and strengths-based to accurately assess students’ social and emotional skills and competencies schools generally rely on vague guidelines for choosing an assessment rather than a specified instrument catalog resulting in less standardized and psychometrically valid assessment practices most schools across Europe rely on translated versions of existing screeners with little established validity evidence and various student self-report instruments to assess students’ SEL competencies Summary of psychometric studies of validity measures across countries Our research strategy was to explore validity evidence for the SSIS SELb translations via examination of concurrent and predictive validity correlations between the SSIS SELb SEL Composite and scores from the SDQ and CD-RISC across participating countries We expected several broad outcomes to emerge: 1) Because they measure similar positive social behaviors we expected scores from the SDQ Prosocial Behavior subscale to correlate positively and moderately with scores from the SSIS SELb SEL Composite for all informants 2) Based on prior literature establishing negative relationships between positive SEL skills and emotional behavior concerns (e.g., Elliott et al., in press; Giannakopoulos et al., 2013) we anticipated that scores from negatively valenced SDQ subscales (Emotional Symptoms; Conduct Problems; Hyperactivity/Inattention; Peer Relationships Problems) to correlate negatively and moderately to strongly with the SSIS SELb SEL Composite Scores across informants 3) Based on established relationships between SEL and resilience (e.g., Reyes et al., 2013) to correlate moderately positively with the SSIS SELb SEL Composite scores These anticipated outcomes specifically are in reference to concurrent validity correlations—we expected predictive validity correlations to be weaker in magnitude relative to their concurrent validity counterparts Beyond evaluating these overall relationships we compared them across countries to determine whether validity evidence was substantially different for any SSIS SELb translation Demographic characteristics of concurrent validity samples Different demographic characteristics were available for each sample based on what information was deemed relevant for each informant. A full breakdown of demographic characteristics of participants can be found in Table 2 Reliability coefficients (Cronbach’s α) for analytic measures across countries The SDQ is an emotional and behavioral screening questionnaire developed to measure the mental health of children and adolescents from 3 to 16 years old. This measure is comprised of five subscales, four of which assess difficulties (Emotional Symptoms, Conduct Problems, Hyperactivity/Inattention, Peer Relationships Problems), and one assesses strengths (Prosocial Behavior; Goodman, 1997) each distributed evenly across the five subscales All responses are rated on a 3-point Likert scale (0: “not true”; 1: “somewhat true”; 2: “certainly true”) The responses for the Prosocial Behavior subscale are reversed in valence so that the total score indicates the overall level of severity of problem behaviors Some exceptions to this rule for internal consistency included the Conduct Problems and Peer Relationship Problems scales of the parent and student report forms the Greek self-report sample had notably lower test-retest reliability coefficients relative to other countries the Romanian student self-report sample and the Greek parent report sample Reliability coefficients for the current sample were fairly strong with the exception of the test-retest reliability coefficient for the Greek sample In the piloting phase it was decided that 1,000 students were to be selected from each of the six participating country clustered by group (experimental control) and by age (4–6 lower secondary and upper secondary students The 250 students selected from each age cohort were to be allocated equally in the experimental (125) and control (125) groups The expected total sample size (6,000) would guarantee a maximum margin of error of 1.27% assuming a 95% confidence level Cluster sampling was used to select the schools ensuring good geographical representation (and age and school level) while stratified sampling was used to select the students from several classrooms within the selected schools Selected students and their respective teachers and parents then completed the respective questionnaires The administration of questionnaires was either completed online (in the case of teachers and older students) whilst in most instances parents completed the questionnaires manually and returned them sealed to the school; in such instances the researchers from that particular country then inputted all answers in the electronic data base The data file was accessed only by the project evaluation team led by the University of Malta the primary school students completed the questionnaire manually in class with data inputted into the electronic data base by the respective research teams Ethical approval was obtained from the respective academic institutions and educational authorities and all participants gave their consent before completing the questionnaires The project evaluation team at the University of Malta in collaboration with the project coordination team at the University of Milano-Bicocca worked with the main researchers in the six implementing countries to ensure quality implementation and evaluation of the program including translation and use of instruments and duration and frequency of implementation were agreed upon by the whole team to ensure consistency in program implementation and evaluation a training support team was set to coordinate activities related to the training courses and supervisions of teachers the translation and adaptation of the handbooks and guidelines and to organize and lead the meetings for school leaders and parents Teachers in the experimental condition received 16 h of initial training in order to receive practical and theoretical knowledge about mental health promotion in the school context as well as tools and materials to implement the program The training was carried out face to face and/or remotely depending on national COVID-19 health regulations teachers also received 9 h of mentoring and monitoring by qualified program trainers The implementing teachers were provided with a manual of activities developed by the consortium as part of the project; their students and parents also received a handbook A set of procedures were also applied to monitor the quality of the implementation across schools and countries These included the assessment of program’s fidelity (the extent to which the implemented intervention corresponds to the originally intended program) dosage (which refers to how much of the intervention has been delivered) quality (related to how well different program components have been conducted) participants’ responsiveness (referring to the degree to which the program stimulates the interest and engagement of participants namely teachers and parents) and adaptation (related to changes made in the original program during implementation not all teachers were able to do 12 activities with the number of sessions varying considerably particularly between countries due to health policies in place related to the pandemic The majority of the 423 implementing teachers (59%) completed 10 or more activities but 31% completed only 4 or fewer activities small correlations ≈0.10; medium correlations ≈0.30; large correlations ≈0.50) We completed our correlational analyses twice: first with concurrent data and second with predictive data we used pre-test data from the broader study and included both experimental and control cases because neither group had received intervention at pre-test we only used control cases to ensure that the provision of the intervention being tested would not influence our results and student versions of the SSIS SELb and outcome measures; however the CD-RISC was only used with student respondents Mean scores and their standard deviations for all measures by country-focused samples and informants are documented in Table 4 (Concurrent validity sample) and Table 5 (Predictive validity sample). Validity correlations are presented in Table 6 and cross-country comparisons in validity correlations are found in Table 7 Means and standard deviations for concurrent validity samples across country Means and standard deviations for predictive validity samples across country Validity coefficients for SSIS SELb composite across country Statistically significant validity correlation differences across country we completed correlational analyses for concurrent validity correlations Regarding SSIS SELb Composite—SDQ correlations correlations generally were negative and medium for the SDQ Emotional Symptoms scale (−0.46 < r < −0.23; Mdn = −0.37); negative and large for the SDQ Conduct Problems scale (−0.65 < r < −0.58; Mdn = −0.61) and the Hyperactivity/Inattention scale (−0.71 < r < −0.64; Mdn = −0.68); negative and generally medium/large for the SDQ Peer Relationship Problems scale (−0.54 < r < −0.42; Mdn = −0.48); and positive and strong for the SDQ Prosocial scale (0.65 < r < 0.77; Mdn All correlations were significant (p < 0.05) Correlations were statistically significantly different across countries for the SDQ Emotional Symptoms but were not statistically significantly different for the SDQ Conduct Problems and SDQ Hyperactivity/Inattention scales the correlation for Romania (r = −0.46) was stronger in magnitude relative to Croatia (r = −0.32) The correlation for Portugal also was weaker than Croatia the correlation for Greece was stronger in magnitude relative to Croatia No other correlations were statistically different across countries Regarding predictive validity correlations patterns mirrored concurrent validity correlations correlations between the SSIS SELb SEL Composite and SDQ scales were negative and small to medium for the SDQ Emotional Symptoms scale (−0.54 < r < −0.18; Mdn = −0.25); negative and generally large for the SDQ Conduct Problems (−0.57 < r < −0.45; Mdn = −0.52) and Hyperactivity/Inattention (−0.69 < r < −0.53; Mdn = −0.62) scales; negative and generally medium for the SDQ Peer Relationship Problems scale (−0.51 < r < −0.32; Mdn = −0.42); and positive and strong for the SDQ Prosocial scale (0.55 < r < 0.61; Mdn all correlations were significant (p < 0.05) Predictive correlations were not statistically significantly different for SDQ Conduct Problems but correlations were statistically different across countries for the SDQ Emotional Symptoms scale the correlation between the SSIS SELb SEL Composite and SDQ Emotional Symptoms scores was statistically significantly stronger for Romania (r = −0.54) compared with all countries including Croatia (r = −0.18) No other correlations were statistically significantly different across countries We replicated correlational analyses for the SSIS SELb Parent SSIS SELb SEL Composite and SDQ scores were negative and generally small for SDQ Emotional Symptoms scores (−0.33 < r < −0.19; Mdn = −0.24); negative and generally strong for SDQ Conduct Problems scores (−0.52 < r < −0.48; Mdn = −0.51); negative and generally medium for SDQ Hyperactivity/Inattention scores (−0.52 < r < −0.44; Mdn = −0.46); negative and generally small for SDQ Peer Relationship Problems scores (−0.35 < r < −0.28; Mdn = −0.29); and positive and generally strong for SDQ Prosocial scores (0.44 < r < 0.65; Mdn Correlations were not statistically different across countries for SDQ Conduct Problems; SDQ Hyperactivity/Inattention; and SDQ Peer Relationship Problems scales the correlation for Portugal (r = −0.19) was statistically significantly weaker than both Latvia (r = −0.33) and Romania (r = −0.32) but no other correlations were statistically different across countries SEL Composite correlations were weaker for Portugal (r = 0.44) relative to Croatia (r = 0.65) and Romania (r = 0.59) but no other correlations were statistically significantly different across countries Regarding cross-country correlation differences correlations were not statistically significantly different for correlations involving the SDQ Emotional Problems Although the omnibus test for correlation differences involving the SDQ Peer Relationship Problems scale was statistically significant (p = 0.013) after application of the Benjamini-Hochberg procedure only one individual country comparison was statistically significant the correlation for Romania (r = 0.06) was statistically weaker than the correlation for Latvia (r = −0.29) Correlations also differed across countries for the SDQ Prosocial scale the correlation for Latvia (r = 0.65) was statistically larger than Greece (r = 0.40) Portugal (r = 0.36) and Romania (r = 0.35) but no other correlations were different across countries correlations were not statistically significantly different across countries for the SDQ Conduct Problems Correlations did differ across countries for the SDQ Emotional Symptoms and SDQ Peer Relationship Problems scales the correlation for Greece (r = −0.43) was statistically larger in magnitude than the correlation for Italy (r = 0.10) and Latvia (r = 0.02) but no other correlations were statistically significantly different across country For the SDQ Peer Relationship Problems scale the correlation for Portugal (r = −0.29) was statistically larger in magnitude than the correlation for Italy (r = 0.02) but no other correlations were statistically significantly different across countries This study was undertaken to examine concurrent and predictive validity evidence for the Composite scores from the translated versions of the multi-informant SSIS SELb Scales. This universal screening scale was developed in the United States and based on the CASEL five competency framework (CASEL, 2015) and parent forms of this assessment of children’s social emotional learning were translated as part of an investigation of the effectiveness of a mental health program (PROMEHS) delivered in schools across six European countries Using existing translated versions of the SDQ a widely used multi-informant rating scale of children’s prosocial and problem behavior a self-report measure of resilience behaviors assessment results for large and representative samples of children were used to provide insights regarding the theoretical construct of SEL competency and validity of scores from translated versions of the SSIS SELb Scales This construct and social behavior representative of it was the central outcome variable of the PROMEHS project and expected to be associated with children’s mental health and school success As expected based on our guiding theory about the development and relevance of SEL competences to children’s mental health and schooling to support that SDQ Prosocial scores of students were correlated positively and moderately with the SSIS SELb SEL Composite the validity coefficients were highly consistent across the six participating countries and three informant types with (a) concurrent correlations always stronger than their corresponding predictive correlations and (b) nearly all these correlations in the moderate to high range These findings provide strong evidence of the convergent validity of scores from the translated SSIS SELb scales there was substantial evidence from students’ self-ratings to support the supposition that scores from the 10-item CD-RISC correlated moderately positively with the Composite SEL scores on the SELb across all countries (a) the concurrent validity coefficients were higher in magnitude than the predictive coefficients and (b) nearly all the indicators of the relations between the SEL and resilience scores were in the moderate range It does suggest that students’ self-ratings should be interpreted with these considerations in mind the fact that it held for student raters as well could also point to differential relations with negative behaviors and outcomes that could be important foundations of future validation work for the SSIS SELb and similar measures Our cross-country comparisons also yielded some interesting and potentially important results The most striking trend was that validity evidence tended to be weaker in magnitude for the Portuguese SSIS SELb and stronger in magnitude for the Romanian SSIS SELb These patterns held only for teacher and parent informants and did not seem to be present for students Although these patterns could indicate problems with the translation of the Portuguese SSIS SELb this seems unlikely because the differential validity relationships were only present for the SDQ Emotional Symptoms It is possible that these SDQ scales have some translation or validity issues that need to be resolved with further research it is possible that cultural differences in Portugal and Romania explain the weaker relationship between SEL and these social constructs in Portugal and the stronger relationship between them in Romania Future cross-cultural research is warranted to better understand the nature and importance of SEL across European cultures although it was not the goal of this study to consider the reliability of these translated scales the reliability of scores from the SSIS SELb were strong and would support widespread research applications and A notable exception to this conclusion was for the Greek SSIS SELb-S which showed notably lower test-retest reliability than SSIS SELb scores from other informants or countries This finding held for other informants in Greece (parents) and for other scales with Greek students (both the SDQ and the CD-RISC) so it may have been an idiosyncratic feature of data collection of this study further research is necessary to support the use of the SSIS SELb in Greece Extant group studies could evaluate whether this pattern and other known patterns across extant groups (e.g. disability status; socioeconomic status; etc.) holds with scores from translations of the SSIS SELb to further support the validity of scores from these measures although the validity data from the study provide promising evidence for score inferences more data are needed to support specific applications in European schools Because the SSIS SELb was created primarily to be a universal screener conditional probability analyses might be a most profitable next step and base rate data would be beneficial as well although the SSIS SELb is not scored based on norm-referenced score interpretation further work evaluating whether its criterion-referenced scoring approach is cross-culturally equivalent would greatly support the use of the SSIS SELb in the included European countries multi-informant study with translated versions of the SSIS SELb Scales provide support for the validity of their score inferences the patterns of convergent and predictive validity indices for these translated measures of social emotional learning were consistent with our theoretical model of SEL competence and were quite consistent across the six European countries with a diverse sample of children Although additional research is necessary regarding specific applications of each translated version of the SSIS SELb Scales concurrent and predictive relations provide promising evidence for the validity of the Composite scores across multiple informants The raw data supporting the conclusions of this article will be made available by the authors The studies involving human participants were reviewed and approved by the University of Milano-Bicocca Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin and drafted several sections of the manuscript as well as the tables drafted the sections “Introduction” and “Discussion,” and revised the entire manuscript drafted a large section of the “Introduction” and a table P-WL consulted on statistical analyses and revised the manuscript JD revised the manuscript and wrote the conclusion of the manuscript and participated in the design and revision of the manuscript and EC contributed to the overall coordination of the project and AC contributed to the data collection and to the revision of the manuscript All authors contributed to the article and approved the submitted version This study was conducted within the EU funded Erasmus+ KA3 research project “Promehs-Promoting Mental Health at Schools” (No This study was based on the Erasmus Plus project Promoting Mental Health at Schools PROMEHS (Project ref n: 606689-EPP_2018-2-IT-PI-POLICY) coordinated by the University of Milano—Bicocca (Italy) and co-funded by the European Commission PROMEHS includes eight other European partners: The University of Latvia (Latvia) and the Regional School Office of Suceava (Romania) as the publisher of the SSIS SEL Brief Scales supported this research through a no-cost User Agreement allowing translation and adaptation of the Teacher and Student versions of the assessment for data collection in the six participating PROMEHS countries The SSIS SEL Brief Scales were published by SAIL CoLab and JD received royalties from their distribution Royalties were waived with regard to the assessment for this study The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Carmel Cefai, Y2FybWVsLmNlZmFpQHVtLmVkdS5tdA== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish There are more than 600 people on the waiting list to get a plot at one of the city’s community gardens vegetables and herbs in a 400-square-foot plot at the Moiliili Community Garden one of 10 city-run and city-funded community gardens on Oahu Right now the 38-year-old medical technician is growing collard greens cassava and a smattering of native ferns and plants He says there are times when 100% of the produce he consumes comes from this small garden “It started off as something that I could do to grow my own food who lives in an apartment in Makiki with no lanai or garden space it’s had a major therapeutic and mental health impact on me Sometimes I go to the garden literally to just be there.” has fostered an appreciation in growing plants the gratification I get when a seed I planted has sprouted into a plant that’s providing me food I’m lucky, though. Where I live I have enough outdoor space to grow beans, sweet corn, kale, apple and lemon trees, carrots and beets. With so much of Oahu’s population living in condos or densely populated urban neighborhoods — and our state’s heavy reliance on imported food — the city’s community gardens program is a vital piece in food security and sustainability and it seems like this program should get way more attention — and Expansion is happening — slowly and maybe a bit unconventionally — but it is happening With funding from the American Rescue Plan Act the city was able to hire a community gardens project manager who has been assessing the current program and looking at feasible something Oahu residents have been requesting for years It’s not uncommon for people to be on the waitlist for high-demand gardens — Ala Wai the city installed seven ADA-accessible raised garden beds at the community garden next to Foster Botanical Garden The 10-foot by 10-foot beds are high enough that a wheelchair can fit underneath them Mines is also working with various community groups schools and nonprofits to help them with their own urban gardens She’s creating a comprehensive guide with information about how to start and maintain a community garden in the Islands “The city has 50 years of expertise running the community gardens program,” she says there are more than 600 people on the waiting list to get a plot at one of the city’s 10 community gardens Mines says the city is planning to open its 11th garden within the next five years — its first since the 1990s it needs consistent funding and staff support Starting a community garden isn’t as easy as measuring out plots and assigning them to residents That’s where creative partnerships have worked In December 2020 the Honolulu Department of Community Services created more than 160 garden beds and planted 20 fruit trees at seven city-owned special-needs housing locations including kupuna housing in West Loch and Manoa and shelters for homeless and at-risk families The project was funded by a Food Security-Scaping Program seeded with CARES Act Coronavirus Relief Funds The city’s community gardens program offered the inspiration and knowledge to this project sustainable produce to those most affected by the pandemic The city has also provided its expertise to Kuilima Farm, a 468-acre agricultural parcel owned by Turtle Bay Resort in Kahuku. The farm, managed by Pono Pacific has 34 community garden plots available to North Shore organizations and residents “Finding the land for a community garden isn’t the hardest part,” Mines says Honolulu Civil Beat is a nonprofit organization and your donation helps us produce local reporting that serves all of Hawaii She is currently the editor at large for Hawaii Magazine and lives in Honolulu with her husband You can follow her on Instagram @catherinetothfox Opinions are the author's own and do not necessarily reflect Civil Beat's views Ideas is the place you'll find essays, analysis and opinion on public affairs in Hawaiʻi. We want to showcase smart ideas about the future of Hawaiʻi, from the state's sharpest thinkers, to stretch our collective thinking about a problem or an issue. Email news@civilbeat.org to submit an idea Sign up for our FREE morning newsletter and face each day more informed .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By South Jersey Times HAINESPORT — Leo Selb Jr. will become township administrator-clerk in Hainesport The appointment was approved by a township committee resolution Selb said he will leave he post he has held the Fairfield post for 22 months on Dec 18 he served as business administrator for the Harrison Township fire department after retiring as police chief of Woodbury Heights Volume 6 - 2012 | https://doi.org/10.3389/fnins.2012.00147 Near-infrared spectroscopy (NIRS) is susceptible to signal artifacts caused by relative motion between NIRS optical fibers and the scalp These artifacts can be very damaging to the utility of functional NIRS particularly in challenging subject groups where motion can be unavoidable A number of approaches to the removal of motion artifacts from NIRS data have been suggested In this paper we systematically compare the utility of a variety of published NIRS motion correction techniques using a simulated functional activation signal added to 20 real NIRS datasets which contain motion artifacts and Kalman filtering approaches are compared to one another and to standard approaches using the accuracy of the recovered simulated hemodynamic response function (HRF) Each of the four motion correction techniques we tested yields a significant reduction in the mean-squared error (MSE) and significant increase in the contrast-to-noise ratio (CNR) of the recovered HRF when compared to no correction and compared to a process of rejecting motion-contaminated trials Spline interpolation produces the largest average reduction in MSE (55%) while wavelet analysis produces the highest average increase in CNR (39%) we recommend the routine application of motion correction techniques (particularly spline interpolation or wavelet analysis) to minimize the impact of motion artifacts on functional NIRS data movement of the head of the subject will invariably cause motion between each optical fiber and the scalp This relative motion will cause a rapid shift in the optical coupling between the fiber and the scalp which typically results in a period of high-frequency noise in the recorded NIRS data the optical coupling is often irrevocably altered causing a shift in the baseline measurements of HbO and HbR Because the magnitude of this motion-induced noise is typically far greater than the changes associated with tissue hemodynamics any changes in hemoglobin concentrations in the cerebral cortex which coincide with motion artifacts are usually so heavily contaminated that they are indiscernible once motion artifacts have been identified there is no well-established approach to their removal or correction the standard approach to motion artifacts in functional NIRS data is to either attempt to insure that there are enough stimulus trials to minimize the average impact of the artifacts or simply to remove any stimulus trials that coincide with identified artifacts Subject groups that tend to exhibit extensive motion are often also the groups for whom the duration of NIRS recording is limited In such cases the number of stimulus trials is also limited This can make it impossible for motion artifacts to be removed by a process of averaging while trial rejection can reduce the effective number of stimulus trials even further reducing the contrast-to-noise ratio (CNR) of the estimated hemodynamic response function (HRF) Motion artifacts are typically observable in multiple NIRS channels and have a scale and frequency composition that are distinct from the background NIRS signal a variety of signal processing approaches have emerged that attempt to reduce or remove motion artifacts from functional NIRS data in order that the corrected data can contribute to the estimated HRF In the context of NIRS experimental design these motion correction methods fall in to two distinct categories: those which require some additional input beyond the standard NIRS dataset (and therefore require an alteration of experimental design) and those that do not state-space based approach to the recovery of signals that are contaminated by noise and (assuming the NIRS time-course contains some periods of data that are motion-free) can be applied without the need for additional inputs but it was not possible to meaningfully quantify the improvement because the true hemodynamic response was unknown In this paper we present a systematic comparison of four recently promoted motion correction algorithms by applying them to real motion artifact contaminated NIRS data By adding a number of synthetic HRFs to each dataset and then attempting to recover the average HRF we are able to simulate a functional NIRS study and assess each motion correction technique in terms of the improvement in the accuracy of the recovered HRF The accuracy of this recovery can then be compared to that achieved without motion correction and by simply removing motion-contaminated trials entirely If the standard deviation increases by a factor exceeding SDThresh or the peak-to-peak amplitude exceeds AMPThresh then data from the beginning of that window to tMask seconds later is defined as motion tMotion = 0.5 s and tMask = 2 s are effective in most cases as we did not wish to test the validity of this detection approach here and simply needed to identify motion as accurately as possible SDThresh was fixed individually for each dataset (at values between 12 and 20) in order to maximize the accuracy of motion identification as determined by visual inspection (Note that the output of this algorithm is not channel-specific signal changes which are determined to be artifact in one channel are marked as motion in all channels; this relies on the reasonable assumption that motion artifacts affect multiple channels) an average of 10.6% of each NIRS dataset was identified as motion The average duration of a given period of artifact was 4.2 s (though note that tMask = 2 s determines the minimum length of each motion artifact) This suggests that the majority of artifacts are brief and likely take the form of transient spikes This is consistent with our experimental experience The application of PCA transforms an N-measurement NIRS dataset into N linearly uncorrelated components ordered by their contribution to the variance of the data The magnitude of motion artifacts is typically much larger than the background NIRS signal Motion artifacts are also typically present on multiple NIRS channels The application of PCA to the filtering of NIRS data makes the assumption that motion artifacts provide the dominant contribution to the variance of the NIRS data and that therefore the first r principle components will account purely for motion artifact These r components can then be removed before the data is analyzed further the PCA motion correction consists of first performing singular value decomposition on the spatial correlation matrix YTY such that: where U is the orthogonal matrix of spatial eigenvectors and Ω is a diagonal matrix of the associated eigenvalues, both of dimensions N × N (Zhang et al., 2005) The first r eigenvectors can then be removed from the data where Ar is a N × N matrix with the first r diagonal elements equal to 1 The performance of PCA in removing motion artifacts from NIRS data is heavily dependent on two factors: the number of NIRS measurements in a dataset [as this defines the number of components (N)] and the number of components that are removed (r) Note that the number of NIRS measurements is twice the number of channels as we define them: each channel consists of measurements at two different wavelengths The optimum value of the parameter r will clearly depend on the total number of components (N) and on how many of those components constitute artifact A simple way to approach the selection of r is to normalize the diagonal elements of the matrix Ω by their sum to produce the vector Ω˜ The nth element of Ω˜ then provides a measure of the proportion of the NIRS data variance that is accounted for by the nth component By fixing the proportion of data variance that is to be removed (referred to from herein as σ_PCA) the number of components to remove (r) can be defined by finding the lowest value of r for which: We employed the discrete wavelet analysis and filtering approach described by Molavi and Dumont (2012). While a detailed description of wavelet decomposition is not provided here (see Strang and Nguyen, 1996; Molavi and Dumont, 2012) in summary each NIRS data time-course is transformed into the wavelet domain using the general discrete wavelet transformation: The approach described by Izzetoglu et al. (2010) was the basis for our Kalman filtering of NIRS motion artifacts Kalman filtering is a state-based recursive technique that acts on noisy data to provide a statistically optimal estimate of the underlying signal and is essentially a two-step process The first is to use prior knowledge of a state to make a prediction of a future state and its uncertainty This prediction step models the state x at time = k based on the state at time = k−1 such that: where A is the transition model (which uses knowledge of the prior state to predict the current state) and γk is the system noise This prediction is then compared to the actual measured state at time = k which is modeled as a function of the true state x: For the application of the Kalman filter to the reduction of NIRS motion artifacts, the translation model was an auto-regressive model based on the Yule–Walker method, with a model order M = 4. This was the highest model order that remained stable on application to our data, and is also that recommended by Izzetoglu et al. (2010) The M Yule–Walker coefficients were calculated on a measurement-by-measurement basis by taking the correlation between the longest period of motion-free data and itself The system and measurement noise were taken to be the variance of the motion-free NIRS data and the variance of the entire time-course respectively for each NIRS measurement periods of motion were determined by the algorithm hmrMotionArtifact Figure 1 shows an example of a single motion artifact in a period of NIRS data and the results of the correction of that motion artifact using a band-pass filtering and Kalman filtering (all also in combination with the same band-pass filter A single motion artifact from one of our 20 NIRS datasets and the effect of band-pass filtering (between 0.01 and 0.5 Hz) Note that the same band-pass filter is also applied after each motion correction technique These amplitudes are approximately equivalent to an intensity change of 0.9% from baseline for the 690 nm channels and 2% from baseline for the 830 nm channels Three of the eight NIRS channels from each of the 20 NIRS datasets were randomly selected and the simulated HRF was added to the OD time-course of these channels at the 25 onset positions defined by the timing vector the automatic motion detection algorithm hmrMotionArtifact was applied to each NIRS dataset to define periods of motion after the simulated HRFs had been added to the data Once the simulated functional dataset had been completed, it was then passed through six different processing streams. The first was the recovery of the HRF without motion correction or the rejection of trials. The data was band-pass filtered (a third order Butterworth filter between 0.01 and 0.5 Hz) to remove low-frequency drift and cardiac oscillations before being converted into HbO and HbR using the modified Beer–Lambert law (Obrig et al., 2000) The periods of data around each of the 25 stimulus trials were then block-averaged to produce the mean HRF The second processing stream was a standard trial rejection NIRS processing approach After band-pass filtering the output of hmrMotionArtifact (calculated previously) was applied such that if a stimulus trial coincided with a defined period of motion The remaining stimuli periods were then block-averaged in order to recover the mean HRF The first step of the remaining four processing streams consisted of the implementation of each of the four motion correction techniques: PCA The resulting corrected data was then subjected to the same band-pass filter as the standard processing approaches irrelevant of how effective the motion correction process may have been were then included in the block-average calculation of the mean HRF This entire process was repeated five times for each dataset using a different random selection of channels and a different stimulus timing vector in order to improve the robustness of the results The result of the simulation process described above was 300 HRFs (20 datasets × 3 channels × 5 repetitions) for each of the six processing streams (no correction Three metrics were then calculated for each processing stream These consisted of the MSE between each recovered HRF and the true (simulated) HRF the Pearson’s correlation coefficient (R2) between the recovered and true HRF and finally the CNR of the recovered HRF The CNR was calculated by taking the mean of the 2 s of recovered HRF data centered at the true HRF peak time (7 s after onset) and dividing by the standard deviation of the 5 s of data prior to onset These three metrics allow a direct comparison of the accuracy of the HRFs recovered via standard NIRS processing approaches and via each motion correction method All metrics are calculated on the basis of the recovered HbO signal only for computational simplicity Several of the motion correction techniques applied here require the selection of an input parameter that can significantly affect the performance of the technique these parameters are the percentage variance to remove (σ_PCA) the interpolation parameter (p_Spline) and the probability threshold (α_Wav) respectively and are described above In order to optimize the performance of each of these methods it was first necessary to perform a sensitivity analysis for each of these three techniques The simulation described above was repeated for a variety of values for each input parameter Guided by the values of these parameters applied in previous publications and α_Wav was varied from 0.01 to 0.8 trial rejection actually increases the MSE However in this simulation the difference between the MSE for the trial rejection and no correction approaches is not significant in a two-tailed paired t-test (p = 0.18) Figure 2. The MSE between the recovered and true HRF for 300 simulations using trial rejection (y-axis) and no correction (x-axis). Trial rejection produces an increase in MSE in 62% of cases, but there is no statistically significant difference between the MSE achieved by trial rejection and that of no correction. The red asterisks indicate the simulations corresponding to the HRFs shown in Figure 3 These three optimized parameter values were employed in all remaining analyses Examples of recovered hemodynamic response functions (A) Is a case where the initial (“no correction”) HRF is very poor and PCA and wavelet approaches can be seen to improve it (B) Is a case where the initial HRF is reasonably accurate but likely contaminated by motion Here the HRF is improved by trial rejection and all four motion correction techniques (C) Shows a case where the initial HRF is very accurate Trial rejection is detrimental to the HRF as are PCA Scatter plots showing the MSE of each HRF recovered via PCA (A) plotted against that achieved by no correction A clear trend is apparent for wavelet analysis (and to a lesser extent PCA) that indicates a tendency for the MSE to be increased in cases where the initial (no correction) value was low while a decrease in MSE is reliably achieved if the initial MSE is high Scatter plots showing the CNR of each HRF recovered via PCA (A) Figure 4 shows scatter plots of the MSE of the 300 HRFs recovered via PCA (Figure 4A), spline (Figure 4B), wavelet (Figure 4C), and Kalman (Figure 4D) plotted against those achieved with no correction the MSE decreases significantly (p < 0.01 Note that the decrease is also significant for all four techniques when compared to the trial rejection approach All four techniques produce an increase in MSE in a subset of cases (32 All four techniques also show a trend which indicates that motion correction is much more likely to have a detrimental effect if the initial (no correction) HRF has a low MSE This is particularly clear for wavelet analysis where an increase in MSE is common if the uncorrected value was below 10 μM2 while a decrease in MSE is assured if wavelet analysis is applied when the uncorrected MSE is greater than 20 μM2 cases where the initial CNR was between approximately 5 and 15 show a consistent improvement particularly for wavelet and Kalman filtering Each box plot shows the median (line and notch) the 25th and 75th percentiles (the edges of each box) and the most extreme values not considered outliers (whiskers) (A) shows the MSE for no correction (“None”) and each of the four motion correction techniques (B) shows the percentage change in MSE relative to no correction (C,D) show R2 and CNR for no correction (“None”) and wavelet approaches produce a median decrease in MSE of 38 Kalman filtering produces a decrease of only 21% All four methods produce an increase in R2 and wavelet approaches are highly significant (p < 0.01) the change due to Kalman filtering is not significant (p > 0.05) All four methods also produced a significant increase in CNR with wavelet filtering yielding the highest median CNR at 10.9 compared to 6.9 for no correction The pair-wise percentage change in CNR (not shown) was also greatest for wavelet analysis The simulations performed here are designed to closely mimic a real functional NIRS experiment but they still have a number of limitations and our results will not apply to all datasets and all experimental paradigms the performance of PCA is heavily dependent on the number of NIRS channels in a dataset Another potential limitation is the choice of dataset It is possible that the types of motion artifact the background hemodynamic oscillations and the quality of NIRS recording are different in these 20 stroke patients than in a standard functional NIRS study we believe these effects are likely to be negligible One surprising result is that trial rejection does not produce a significant improvement in the recovered HRF compared to no correction (Figure 2) This is almost certainly due to the range of the number of trials rejected in these datasets The minimum number of trials rejected in our simulations was 7 out of 25 It is extremely likely that trial rejection would provide a significant improvement compared to no correction if only a small number of trials were initially rejected As the proportion of rejected trials increases the more likely it is that including those trials will produce a better HRF than rejecting them as motion artifacts will be minimized simply by block-averaging All four motion correction techniques produce an improvement in HRF recovery on average. Spline interpolation provides the highest average decrease in MSE (55%), reduces MSE in 80% of cases (Figure 4) and produces the highest average R2 (Figure 6) while wavelet analysis provides an average decrease in MSE of 50%, reduces MSE in 77% of cases and produces the highest average CNR (Figure 6) best technique depends on which metrics are considered it is clear that spline and wavelet techniques are the most successful The results of Figures 4–6 show that in practice there will be cases where motion correction will be detrimental. The distributions shown in Figures 4A–D suggest that this is much more likely in cases where the uncorrected HRF is already very accurate These cases of low initial MSE are the cases where the number and/or amplitude of motion artifacts is/are small In cases where only a small proportion of stimulus trials are affected by motion artifacts correction approaches may not be suitable and the standard approach of trial rejection would likely be preferable This result is clearly expected for PCA and wavelet approaches the assumptions on which the PCA and wavelet approaches are based will begin to break down and both techniques will begin to remove components of the data that have a physiological origin The fact that wavelet analysis exhibits a clear relationship between the uncorrected MSE and the improvement it can provide may give it an advantage over spline interpolation It may be possible to define a threshold (based on the proportion of data that is affected by motion artifact or the uncorrected CNR) that will determine whether the application of wavelet analysis is suitable and therefore avoid cases where wavelet analysis will be detrimental Although we have attempted to apply these pre-published motion correction techniques in the manner described by their respective authors there are a number of ways in which these techniques could potentially be improved without the need for additional external inputs or for alteration of an experimental paradigm One obvious example is to target the PCA and Kalman approaches so as to only examine periods of data that are pre-determined as motion Wavelet analysis takes advantage of the abnormal spatial and temporal characteristics of motion artifacts in the wavelet domain to identify and remove them Spline interpolation requires knowledge of the location of motion artifacts throughout the dataset and interpolation is only performed for those periods PCA and Kalman filtering are applied to the entire NIRS time-course including periods where we do not believe there is motion artifact These algorithms could easy be altered so as to only be applied during periods of identified motion artifact The variance of the NIRS signal that is due to motion artifact during periods identified as motion artifact will obviously be very large Applying PCA with a high value of σ_PCA to only those periods may produce better results that applying PCA to the entire dataset particularly in cases where motion is not particularly prevalent and therefore accounts for a lesser proportion of the variance of the entire dataset Another obvious advance would be to employ trial rejection in conjunction with a given motion correction technique It would be trivial to apply hmrMotionArtifact to identify motion artifacts still present in the corrected NIRS data and remove any stimulus trials that remain contaminated One can also conceive of a recursive technique whereby motion correction is performed repeatedly until no motion artifacts are detected we set out to test only those motion correction techniques that can be applied after NIRS data acquisition without altering the experimental design and without the need for additional external inputs While we believe this is the most relevant approach to motion correction for the majority of NIRS applications at present We believe the application of both of these techniques can be highly beneficial to functional NIRS analysis The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest We would like to thank Behnam Molavi at the University of British Columbia for assistance with implementing the process of wavelet analysis This work is supported by NIH grants P41RR14075 R01EB006385 (to David A Boas) the Fond Quebecois sur la Nature et les Technologies (to Louis Gagnon) The study of stroke patients was supported by the Augustinus Foundation Automatic detection of motion artifacts in infant functional optical topography studies Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Transient haemodynamic events in neurologically compromised infants: a simultaneous EEG and diffuse optical imaging study Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Functional near infrared spectroscopy (NIRS) signal improvement based on negative correlation between oxygenated and deoxygenated hemoglobin dynamics Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Short separation channel location impacts the performance of short channel regression in NIRS Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling Pubmed Abstract | Pubmed Full Text | CrossRef 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functional near infrared spectroscopy: a comparison of methods Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Measurement of layer-like hemodynamic trends in scalp and cortex: implications for physiological baseline suppression in functional near-infrared spectroscopy Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Two-detector corrected near infrared spectroscopy (C-NIRS) detects hemodynamic activation responses more robustly than single-detector NIRS Pubmed Abstract | Pubmed Full Text | CrossRef Full Text How to detect and reduce movement artifacts in near-infrared imaging using moving standard deviation and spline interpolation Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Accelerometer-based method for correcting signal baseline changes caused by motion artifacts in medical near-infrared spectroscopy Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Dissociation of processing of featural and spatiotemporal information in the infant cortex Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Adaptive filtering to reduce global interference in non-invasive NIRS measures of brain activation: how well and when does it work Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. Set in expansive grounds with an adjoining campsite, the Jochen-Klepper-Haus, a converted villa formerly belonging to the director of a porcelain manufactory, is a highly attractive location well known beyond the region. An architectural competition was initiated to extend the programme by three event halls and the necessary infrastructure with the objective of further developing the venue and making it suitable as a community centre for the Selb-Plößberg district.  As a supplement to the historic villa with its colourful clinker facade, the new building has been developed as a timber frame construction which, through its permeability, links indoor and outdoor space and thus maximises the spatial potentials of the site: the existing population of trees and clearings, the villa’s garden to the west and the view out into the surrounding landscape to the east have become reference values of the location.  © Fernando Alda The demand for different room heights is used to accentuate the hillside position on the outskirts of town; at the same time the building is perceived as a clear silhouette Material and form are reduced to the structural minimum which highlights their expressive character: Slim box beams were prefabricated and preassembled off site The characteristic facade clad in larch strips was mounted in front of a breather membrane on site You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email While history has cast Adolf Hitler as a trailblazing propagandist he has also been portrayed as a successful political campaign speaker - but does this narrative stand up to scientific scrutiny Political scientists from the University of Konstanz and the Hertie School of Governance have now revisited the question as to how effective Adolf Hitler's public campaign appearances were in garnering electoral support in Weimar Germany to be published in the American Political Science Review (APSR) suggest that Hitler's appearances actually had a negligible impact on the Nazi's electoral fortunes before their seizure of power in 1933 Five German parliamentary (Reichstag) elections and one German presidential (Reichspraesident) election were carried out in Germany between 1927 and 1933 the National Socialist German Workers' Party (NSDAP) increased its vote share from a marginal three to an extraordinary 44 percent New research results from Professor Peter Selb at the University of Konstanz and Dr Simon Munzert from the Hertie School of Governance show that Adolf Hitler's 455 public appearances during this period had a surprisingly small effect on the electoral outcomes Peter Selb and Simon Munzert base their findings on election statistics from 1,000 counties and districts as well as from 3,864 municipalities For their analyses they include information on Hitler's campaign locations They also take campaign event appearances of Joseph Goebbels - the second most important speaker for the Nazi movement - into account By using the statistical method of "difference of differences" (DID) the researchers compare election trends in areas where Hitler gave public speeches with the electoral trends from similar areas where he did not appear "We are surprised about how marginal the effect of Hitler's election appearances was especially when one considers contemporary witnesses and historians who have confirmed his exceptional rhetorical abilities" their data assessment demonstrates only minor electoral effects which were very limited in terms of geography and time Hitler's personal involvement only had a positive effect in the run-off election for the office of German president in 1932 This election took place after an unusually short intensive and one-sided election campaign - competitor Hindenburg did not make any public appearances - leading Hitler to garner an estimated additional one to two percentage points in terms of vote share in counties and districts in the immediate vicinity of locations where he made a public appearance before the election The fact that Hitler's campaign is considered a most likely case for campaign effects makes these results all the more extraordinary Hitler utilised new and sophisticated techniques including modern technology such loudspeakers and airplanes These provided Hitler an unparalleled geographic penetration and an unprecedented level of public attention "It is remarkable that Hitler's public appearances and speeches as an early populist and party leader were not very influential especially when one considers the growing body of empirical evidence confirming his propaganda successes as dictator" Research on Germany after 1933 - when the Nazis had begun to gain totalitarian control over the state apparatus and the emerging mass media - has demonstrated that Nazi propaganda had strong and long-lasting effects on the collective perceptions "other studies stress the crucial role that economic and political circumstances played during this time - which includes mass unemployment and economic hardship the alienation between established parties and the electorate as well as weak state institutions - for the rise of the NSDAP we can confirm that Hitler's importance as a charismatic speaker is less significant." Based on this historical evidence the researchers recommend that one should view the accepted opinion that charismatic leaders play a key role in the rise of right-wing populist movements Peter Selb is Professor of Survey Research at the Department of Politics and Public Administration at the University of Konstanz with expertise in survey methodology He is a former principal investigator for Swiss National Election Studies and a contributor to the research area and proposed Cluster of Excellence "The Politics of Inequality" at the University of Konstanz which is currently participating in the German Excellence Strategy competition Simon Munzert is Lecturer of Political Data Science at the Hertie School of Governance in Berlin and completed his Bachelor's Master's and doctoral studies at the Department of Politics and Public Administration at the University of Konstanz His research interests include the dynamics of public opinion and the role of new media in political processes He is a fellow of the Daimler and Benz Foundation and head of the international collaboration project "Media Exposure and Opinion Formation in an Age of Information Overload" which is funded by the Volkswagen Foundation - Authors note that their empirical findings support a skeptical view of the idea that right-wing populist parties require a charismatic leader to rise to power are not responsible for the accuracy of news releases posted to EurekAlert by contributing institutions or for the use of any information through the EurekAlert system Copyright © 2025 by the American Association for the Advancement of Science (AAAS) yet profound film about falling in love with Tillmann Eckardt and Manuel Leuchte (© Holger Borggrefe) All 5 Releases This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By South Jersey TimesThree years ago Republicans Larry Wallace and Vince Nestore broke the Democrats’ 15-year 7-0 hold on Gloucester County freeholder board Their election put the majority under scrutiny that it had not seen for more than a decade Unfortunately, both Republicans capped their freeholder careers after a single term. Wallace is running for the Assembly. Nestore dropped a re-election bid in June This gives voters four non-incumbents for two seats. Our choices are Republican Ed Selb and Democrat Dan Christy. impressed our editorial board with his public safety experience An opponent of his hometown joining the county’s regional EMS service (Harrison Township signed up anyway) he could provide reasonable counterpoint to the Democrats’ gospel that shared services always save money and run like clockwork Christy (don’t confuse his name with the Republican governor’s) is a carpenter’s union official He’s recommended mostly as the best of a trio who project mediocrity the Washington Township resident could connect with the concerns of county parents A reservation is that he conforms to state Sen Stephen Sweeney’s mold for big-labor candidates who show little independent thinking as freeholders Christy deserves a shot over former Democrat freeholder Frank DiMarco He did not serve with enough distinction to return him to the board does not seem better prepared this time around The freeholders’ closing of the county jail this year shut out the public until it was virtually a done deal Selb and Love want freeholder meetings recorded for broadcast who pushed many of the transparency reforms that the board has adopted They’re not hanging around for second terms — The “digital divide” cuts deep and wide across South Jersey but a partnership of this rural township and Comcast Corp promises to allow broadband access everywhere here by early 2024 Hopewell and Comcast will carry out a roughly $1.5 million project to extend existing broadband service to every corner of the township and its approximately 4,400 residents The timetable places the completion date for the first-of-its-kind project 14 months from now I’m very excited to be part of the team that’s been able to bring broadband to the entirety of Hopewell,” Mayor Paul Ritter said someone can live in Hopewell Township and work anywhere in the country This is something that the township has been working toward for 10 years.” More:What the defense says about woman convicted of killing, cremating toddler son More:South Jersey community opens tiny homes to released inmates Ritter and township Administrator Leo Selb said that decade-long push owes much to Greg Facemyer first as a committeeman and finally as deputy mayor “He was extremely instrumental in making this happen He went up and fought with BPU (Board of Public Utilities) originally  Facemyer finished his last day as a township official at the start of the year Ritter and Facemyer said the COVID-19 pandemic really energized the push for 100 percent township access Areas not served by Internet cable have had to struggle along with wireless coverage “And it’s such a great impact to a small community like ours because now we can at least compete with other businesses,” Facemyer said “The students don’t have to go to their grandparents or a relative that does have broadband to complete tests or do their studies because at their (own) homes it’s so unreliable if they’re in an unserved area.” also effectively rejects a competing Internet access development concept from Cumberland County The county proposes building its own broadband infrastructure to cover Cumberland and Salem counties the long and the short of it is the county has a very much more complicated approach to it,” Facemyer said “Instead of the county going to Comcast and saying ‘Do a survey of Cumberland County and tell us who is unserved.’ And they can do that through their records and their engineering department Comcast officially declined to support that proposal responding to a county request for its backing evaluated the initiative as not meeting the true internet access needs of the area and also as unlikely to be financially viable Ritter and Facemyer said the lack of access in the township a very rural and agricultural area covering almost 30 square miles also has been a killer to real estate activity and values That was another major factor in the Comcast agreement “We have had numerous circumstances where residents have contracted to sell their homes and the buyer in their due diligence prior to settlement find out that some residents don’t have broadband or cable TV or the Internet,” Facemyer said “They’ve backed out of real estate transactions because they work from home or whatever reason they certainly want broadband I think the values of the homes will improve.” A town hall for residents who could sign up for service will be held at Hopewell Crest School on Sewall Road and will have Comcast representatives to talk about the project Selb said there are at least 144 houses that are unserved now There will be no connection fee to potential customers with properties 300 feet or less from utility poles that will carry the new lines Selb said 22 houses and three businesses fall outside the 300-foot zone Those owners would have decisions to make about cost versus access The project starts with at least several months of engineering work and obtaining approvals and easements The construction will be covered by three sources of funding including money from an approximately $1.08 million bond the Township Committee approved in September 2022 Selb says not all the bond will be used because of the other funding pieces available Comcast is putting up $407,694 or 27 percent of the cost The company was the only one to respond when Hopewell sought Requests for Proposals from broadband providers Selb said the township end should be $656,791 or 43.5 percent “And the first phase is specifically engineering money .. They are going to pay up all those costs until their funds have been exhausted the next step will be to go to American Rescue Plan funds.” Selb said one challenge in getting to a deal with Comcast was getting the company to understand New Jersey law on government contracting every town will benefit from our forging through the waters to make it happen." Selb said Maurice River Township recently finalized a very similar agreement with Comcast Other communities also have been in contact with questions about Hopewell’s experience In a letter in September to Cumberland County Comcast said the Federal Communications Commission estimates 2.7 percent of homes in Cumberland County are not in reach of “fast reliable wired broadband networks” and another 21.6 percent could have service but do not subscribe Ritter said the importance of broadband access today is comparable to access water and sewer services residents will have access to its Xfinity suite of internet products “including supersonic WiFi technology” and Flex entertainment platform The project also is touting to residents the availability of the federal Affordable Connectivity Program The program provides low-income households a credit of up to $30 per month toward their internet and mobile services Philly native transplanted to South Jersey more than 30 years ago keeping an eye now on government in South Jersey He is a former editor and current senior staff writer for The Daily Journal in Vineland Have a tip? Reach out at jsmith@thedailyjournal.com Help support local journalism with a subscription Too many automated requests from this network Gebrüder Netzsch Maschinenfabrik went on to develop machines for ceramic production Netzsch remains a family-owned company once again headed by two brothers from Selb: Moritz and Paul Netzsch As the fifth generation of the Netzsch family of owners they run the company along with CFO Jens Niessner Netzsch operates three business units: Pumps & Systems Grinding & Dispersing and Analyzing & Testing The company has around 210 production and sales locations worldwide “It is important to me that we have a stable continued development of what we do today,” says Moritz Netzsch with all the necessary rethinking and new thinking and bring the company into the next generation stronger than ever.” Netzsch has had its corporate history researched from a variety of perspectives for its 150th anniversary “Our history provides answers as to why we have existed for so long,” says Paul Netzsch “Our slogan 'Proven Excellence' is no empty phrase We can prove our excellence from our history One can observe how we actively shaped entire industries over many years Netzsch has always been able to adapt to radical changes in the corporate world or in the marketplace Sometimes this also meant that we had to drastically reposition ourselves.” After the Second World War and during the heyday of the porcelain industry Netzsch built complete factories for the ceramic industry “We want to transfer this historically grown adaptability into the future as well,” explains Moritz Netzsch Important milestones in the company's history can be attributed to Erich Netzsch (1903–1990) and Thomas Netzsch (1946–2010) Both managing directors have shaped the company and brought it forward with groundbreaking decisions The discovery and further development of the Mohno pump under Erich Netzsch and the intensive internationalization under Thomas Netzsch are just two examples “You can feel our Netzsch spirit at every location,” says CFO Jens Niessner the perspective for the employees – this pairing sparks an aura that makes us competitive even in places where other companies with a high international profile are located.” Netzsch Pumps & Systems has served markets worldwide for more than 60 years sophisticated solutions for applications in every industry type Netzsch supplies Nemo progressing cavity pumps Peripro peristaltic pumps as well as N.Mac twin shaft grinders Netzsch Pumps & Systems is the largest business unit in the Netzsch Group with annual sales of more than €380 million Free access to this content is for qualifying individuals only Corporate and institutional access requires an appropriate license or subscription For more information contact institutions@markallengroup.com The fire extinguishers from the "Gebrüder Netzsch Maschinenfabrik” were a big seller went on to develop machines for ceramic production that were also renowned for their quality With the boom of the porcelain industry at that time in the Fichtelgebirge the company finally concentrated entirely on the production of the ceramics industry equipment the success story of a family-owned company began which today spans the globe with its three business units "Pumps & Systems" "Grinding & Dispersing" and "Analyzing & Testing" - with products such as the Mohno pump with around 210 production and sales locations and more than 4,100 employees the NETZSCH Group is once again headed by two brothers from Selb: Moritz and Paul Netzsch This is one of the reasons why NETZSCH had its corporate history researched from a variety of perspectives for its 150th anniversary Looking into the past not only substantiates values and successes it also reveals the fit of a value proposition "Our history provides answers as to why we have existed for so long Our slogan 'Proven Excellence' is no empty phrase NETZSCH has always been able to adapt to radical changes in the corporate world or in the marketplace Sometimes this also meant that we had to drastically reposition ourselves," says Paul Netzsch NETZSCH built complete factories for the ceramic industry All of these developments ultimately led to NETZSCH positioning itself very successfully in the market with its "Analyzing & Testing" "Grinding & Dispersing" and "Pumps & Systems" business units "We want to transfer this historically grown adaptability into the future as well," explains Moritz Netzsch CFO Jens Niessner is convinced: "You can feel our NETZSCH spirit at every location the perspective for the employees - this pairing sparks an aura that makes us competitive even in places where other companies with a high international profile are located." The result: Niessner repeatedly experiences deja vu during employee interviews all over the world: "I often meet employees and realize in conversation: the son or daughter now also works for us Our spirit is not only inherited by the owner family NETZSCH is planning extensive celebrations - including at all major international locations The company will share the various facets of its history with its workforce as well as interested members of the public NETZSCH Pumps USA highlights its TORNADO T1 Generation F pump designed to produce high flow at low to medium pressures in a small compact package It is ideal for various industrial applications The pump can handle a wide range of viscosities and corrosive/acidic process fluids and environments The more different suspensions and solutions are conveyed Honeywell Specialty Chemicals GmbH at the Seelze site in Lower Saxony had to contend with heavy wear and cost-intensive system downtimes Quality and efficiency – to guarantee both precision in the handling of fluids is crucial in the chemical industry This was also the case at a long-standing German chemical plant which faced particular challenges when homogenising gel chunks of different sizes The aim was to generate a steady flow with a uniform particle size the leading complex fluid handling solutions provider is proud to announce that Mark Hoke has joined the team as Regional Sales Manager Northeast – Environmental NETZSCH Pumpen & Systeme is expanding its product portfolio in the field of peristaltic pumps with the PERIPRO tube pump The pump has been specially developed for demanding dosing applications and enables efficient pumping in numerous areas of application The Kemptner Hütte near Oberstdorf sits at an altitude of 1 844 m As one of the largest huts of the German Alpine Club (Deutscher Alpenverein it offers long distance hikers and other mountaineers respite and refuge surrounded by majestic peaks The international information and sales platform for centrifugal pumps U16 with 4-nation home tournament in Selb / Künast: “I’m happy that it’s starting” The Women will travel to Russia from February 6th to 11th 2019 to take part in the “Final 6 Tournament” of the Euro Women's Hockey Tour National coach Christian Künast's squad includes three goalkeepers This tournament is new to the women's calendar and marks the end of the international tournament season before the World Championships in April The best six European teams play in two groups and the subsequent placement games to determine the tournament winner It is also the last test for the German team before Künast names his provisional squad for the World Cup preparations that begin at the end of March The German team will face Finland (February 7th CET+2) and the Czech Republic (February 8th the game will be played on February 10th against Russia who are fighting for group victory in the other group women’s national coach: “This tournament is the last opportunity for us to get together again before preparing for the World Cup I have worked intensively with the team over the past few weeks and am looking forward to being able to look after the team for the first time During the ice sessions and games I will be able to get a good impression of how the girls harmonize with each other and what adjustments we still need to make.” things will be exciting in Selb from February 6th to 10th Coach Florian Neumayer nominated two goalkeepers eight defenders and twelve strikers for the four-nation tournament 9:17 p.m.) and the Czech Republic (February 30th The German team does not have the best line-up After Lea Badura and Julia Kohberg had already canceled for school reasons “We would like to thank those responsible at VER Selb and the volunteers in advance for their efforts in supporting the organization of the tournament,” says team and tournament leader Jörg Reimann holding such a tournament would hardly be possible!” You can find the statistics for the tournament Click HERE U16 women’s national coach: “If all players exploit their potential then the tournament should be a successful dress rehearsal for the highlight of the season In the preliminary round we will meet Switzerland and Austria alongside Finland and Norway That’s why the comparisons in Selb are very informative.” Essential cookies enable basic functions and are necessary for the proper functioning of the website Statistics Acquire cookies information anonymously This information helps us to understand how our visitors use our website Content from video sharing platforms and social media platforms is blocked by default access to these contents no longer requires manual consent These are some of the objects that kids of all abilities will be able to enjoy in Hainesport’s new playground which volunteers started to build Saturday morning Around 40 volunteers arrived at the site as early as 6:30 a.m The playground will be accessible to children with developmental and physical disabilities as all new playgrounds are required to be according to the Americans with Disabilities Act is that special needs and non-special-needs children will be able to enjoy the space together without even realizing that it is “special” at all “They (will) have no idea that we’ve designed it so they can play together seamlessly,” Wiley said There will be “able-bodied children and disabled together The playground will be paved so as to be wheelchair-accessible and the equipment is designed to be low to the ground or have ramps Kids can get in with their wheelchair on a couch-shaped glider called a “Sway Fun” or get dizzy in a big spinner which is particularly appealing to children with autism but all kids will likely enjoy playing on the drums and musical scales or spinning the colorful balls built into the wall the accessible playground is being built next to a traditional playground so that parents can watch over children playing in both areas at the same time Volunteers will work through the weekend and officials hope the playground will be done by next week Administrator-Clerk Leo Selb said that he expected there will be a ribbon-cutting ceremony on Sept this would not become a reality unless the community got involved They are not afraid to step up and help out And not to mention that it’s a tremendous savings,” he said Wiley estimated that using volunteer labor to set up the equipment will save the town around $30,000 located at the municipal complex off Marne Highway came from the town’s open space and recreation fund plus a $120,000 grant from the Burlington County Municipal Park Development Program of Cherry Hill completed the initial site work to prepare a base for the equipment for $53,849 Two grandparents at the park on Saturday were particularly glad to help set up the equipment Hainesport resident Jackie Agostini said her granddaughter Ava She thinks Ava will enjoy the upright swings “It’s an exciting concept and it’s in keeping with where we are in terms of understanding that children with special needs need to play right next to children that don’t have special needs,” Agostini said brought up the idea of a new accessible playground at town meetings three years ago Marco Agostini said he’s glad that Hainesport will be the first town in Burlington County to have a “state of the art” playground that is 100 percent compliant with ADA standards “We want to give credit to the mayor and township committee … that have been supporting this project 100 percent,” he said There are also plans for the nonprofit group Build Jake’s Place to construct an accessible playground in Delran modeled after the Jake’s Place playground in Cherry Hill Selb said that eventually all of the playgrounds in Hainesport will become completely accessible HAINESPORT — The Township Committee accepted a bid Tuesday evening to construct an inclusive playground at the municipal complex off Marne Highway the lone bid for the project was rejected because it was higher than the township had estimated The committee decided to rebid the project this month without scaling back the scope according to Township Administrator Leo Selb Jr added to our projected cost for the actual playground brings us to where we need to be for what we had estimated for the project That total includes the playground equipment and other costs The township has received a $120,000 grant from the Burlington County Municipal Park Development Program to pay for the project The rest of the money will come from the town’s open space and recreation fund “The bid we received was just about $20,000 less than the bid we had a couple of months ago,” Wisnosky said referring to the rejected bid from Command Company Inc. The canceled community-build day for the playground The playground will include equipment that encourages sensory play and will be built next to an existing playground and tennis courts at the municipal complex It will include swings that have a harness for use by children with disabilities sensory equipment for children with autism and a handicapped-accessible merry-go-round The project represents the fifth phase of construction at the park The information on this page is intended for journalists If you click NO you will come back to Mynewsdesk.com The German porcelain manufacturer Rosenthal announces the appointment of Ms Lotte Franch as its new Chief Executive Officer She will succeed the current CEO Mads Ryder who will continue in an advisory role until the end of September to ensure a seamless transition In her most recent position as Chief Operating Officer at Rosenthal GmbH Lotte Franch played a pivotal role in leading operational functions and orchestrating effective improvements for the company "We are very pleased to welcome Lotte Franch in her new role at Rosenthal," says Mads Ryder and accomplishments make her the perfect candidate to lead the company forward I have complete confidence in her ability to continue Rosenthal's legacy." With a track record spanning over 35 years Lotte Franch brings extensive international experience and expertise to her new role Her diverse background and deep understanding of different markets make her an ideal fit for Rosenthal's continued expansion and innovation Thomas and Arzberg is one of the most modern porcelain manufacturers in the world Founded in 1879 and based in Selb in Upper Franconia the company produces high-quality porcelain exclusive design objects and stylish accessories in two factories in Selb and Speichersdorf Rosenthal GmbH has been part of the Arcturus Group which is one of the world's leading suppliers of high-quality design products for the table kitchen and home in private households as well as in the catering and hotel industry From Porcelain Pioneer to an International Design Company Rosenthal products stand out for their design Established figures from the worlds of architecture but also the smart newcomers and talents design avant-garde dining collections sophisticated interiors and exclusive gifts Rosenthal has been producing porcelain "Made in Germany" for more than 140 years the two porcelain factories in Selb and Speichersdorf are among the most modern production facilities in the porcelain industry worldwide and deliver sustainable manufacturing with careful use of resources thanks to the forward- looking investments that have been made Rosenthal stands for innovation and design exquisite craftsmanship and finest porcelain When you choose to create a user account and follow a newsroom your personal data will be used by us and the owner of the newsroom for you to receive news and updates according to your subscription settings To learn more about this, please read our Privacy Policy, which applies to our use of your personal data, and our Privacy Policy for Contacts which applies to the use of your personal data by the owner of the newsroom you follow Please note that our Terms of Use apply to all use of our services You can withdraw your consent at any time by unsubscribing or deleting your account Please check the box to confirm your age before continuing A Gebr Heinemann/Unimex joint venture has opened its latest “˜Travel Free’ Shopping Center at the Selb-AÅ¡ border crossing The partnership between Prague-based Unimex Group and Hamburg-based trading company Gebr Heinemann trades as Travel Free s.r.o The alliance described the new store as a “bargain haven” with over 15,000 original branded items on offer The border store is 30km from the German city of Hof “Customers can select from a wide range of products made by well-known manufacturers costs almost half as much as in the German national market and savings of up to -40% can be made on a pound of coffee while at prices between €15 and €20 lower here than elsewhere an exquisite perfume becomes the ideal gift for Christmas.” In addition shoppers can choose from a wide assortment of clothing bearing the S The Shopping Center is located just after the Selb border crossing which is used every month by around 400,000 Germans to enter the Czech Republic It also features a conveniently located service station at what the joint venture described as “irresistibly attractive” prices customers will be able to dine in the Center’s restaurant or use the in-house casino ABOUT THE ‘TRAVEL FREE’ CONCEPT value-for-money shopping has been a feature at the Germany-Czech Republic border Until 2004 shops located between the passport control posts could offer their goods free of customs and tax charges However with the entry of the Czech Republic into the European Union in May 2004 the Travel Free concept became the German-Czech equivalent of travel retail at border crossings Gebr Heinemann Manager for Eastern Europe Ralf Tiedt said: “Our many years of contact with brand owners and suppliers in addition to our business relationships here in the Czech Republic of the benefits of maintaining the popular border shops.” As a result customers will continue to be able to take home up to 20lb of coffee or 20 litres of spirits with an alcohol content by volume of less than 22% When they pay staff in the shop check that the maximum of permitted export quantities (including 90 litres of wine or 110 litres of beer) are not being exceeded Smokers also have reason for Christmas cheer – from the start of 2008 instead of the one carton of cigarettes previously allowed they will now be permitted to buy as many as 800 cigarettes From 1 January 2008 the Schengen agreement will apply to the Czech Republic With the removal of the obligation to present their passports Germans will be able to enter their neighbouring country even more quickly Penetration rates are very high – Gebr Heinemann said that every second person crossing the Czech-German border buys something in a Travel Free Shop ABOUT THE GEBR HEINEMANN/UNIMEX JOINT VENTURE operates Travel Free Shops at the German-Czech border crossings of Selb-AÅ¡ Sohland-Å luknov Rožany Waidhaus-Rozvadov and Furth im Wald-Folmava as well as at the Austrian-Czech crossings at Weigetschlag-Studánky Wullowitz-Dolní DvořiÅ¡tě and Drasenhofen-Mikulov the Unimex Group is one of the largest companies in the Czech Republic It acts as a wholesaler and retailer for international brands and the DIY market in project development for industry and hotels Before the foundation of the joint venture Gebr Heinemann was an exclusive supplier to Unimex’s border shops owned and managed by the Heinemann family since 1879 is one of the biggest players in the travel retail industry As a wholesaler it supplies over 1,000 customers in 70 countries In retail Gebr Heinemann is active at a total of 31 international airports at which it operates 180 Travel Value & Duty Free Shops in addition to 40 franchised brand boutiques and its own specialist shops Mauritius Duty Free Paradise Co weighs up strategic options for distribution following tender impasse – 06/12/07 Gebr Heinemann opens first Kiehl’s shop in Denmark – 05/12/07 Frankfurt Airport brings a contemporary flavour to enhanced food & beverage offer – 04/12/07 Frankfurt’s shopping revenues flourish – 23/11/07 Subscribe to our newsletter for critical marketing information delivered to your inbox is relaunching its annual whisky festival under the name Whisky Social Club Our latest images come courtesy of Warsaw Chopin Airport which is inviting guests to experience “an extraordinary journey into the world of Star Wars” until 4 May Today’s images come courtesy of Düsseldorf Airport which is currently sporting an orange theme and playful signage renaming it ‘Luchthaven Düsseldorf’ Copyright © The Moodie Davitt Report | Website by Yellowball We use cookies to ensure that we give you the best experience on our website Please click on one of the buttons below to accept We use cookies to help you navigate efficiently and perform certain functions You will find detailed information about all cookies under each consent category below The cookies that 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understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns ' + scriptOptions._localizedStrings.webview_notification_text + ' " + scriptOptions._localizedStrings.redirect_overlay_title + " " + scriptOptions._localizedStrings.redirect_overlay_text + " This file fixes the no gauge problem with the Project Open Sky Bombardier Canadair Regional Jet CRJ200 when used in FSX If your Flight Simulator X is located in C:\Program Files\Microsoft Games\Microsoft Flight Simulator X extract the CRJ200_FSX_FIX.zip file to C:\ If your flight simulator resides elsewhere or is named differently extract the CRJ200_FSX_FIX.zip file to a temporary directory and mode the folder named "SimObjects" to your Flight Simulator X directory View important Copyright © information related to freeware files here The archive crj200fx.zip has 18 files and directories contained within it This list displays the first 500 files in the package Signing-up for PRO gives you super fast, unrestricted speed to the thousands of MSFS, FSX, P3D & X-Plane downloads which include aircraft, scenery, and more - click here to view the library for free or.. Sign-Up Now PRO membership payments go directly back into the website to pay for hosting It's what also enables us to offer a free download tier Join over 145,000 subscribers of our free dedicated flight simulation newsletter Are you using the latest Microsoft Flight Simulator 2024 release Panel has been aliased to the default CRJ700 CF34 turbofan sound set by Christoffer Peterson Screenshot of Mesa Airlines Bombardier CRJ 900 on the ground extract the CRJ900_FSX_v2.zip file to a temporary directory and mode the folder named "SimObjects" to your Flight Simulator X directory The archive pos900fx.zip has 6 files and directories contained within it 28 November 2016) At this year's annual conference in Innsbruck the Austrian Society for Allergology and Immunology (ÖGAI) awarded prizes to two researchers from MedUni Vienna for works in the field of immunology Anna Gieras won the Clemens von Pirquet Prize and Regina Selb received a Dissertation Prize the Austrian Society for Allerglogy and Immunology awards the Clemens von Pirquet Prize for outstanding works in the field of allergy research the international panel of experts chose Anna Gieras from the Institute of Pathophysiology and Allergy Research at the Medical University of Vienna (currently with the Institute of Immunology University Medical Center Hamburg-Eppendorf She received the prize for her work entitled "IgE epitope proximity determines immune complex shape and effector cell activation capacity" which has been published in the Journal of Allergy and Clinical Immunology (137 (5):1557-15565 studied genetics and microbiology at the University of Vienna Her interest in allergy research was influenced by her mentor Even while she was writing her dissertation at the Institute of Pathophysiology and Allergy Research at the Medical University of Vienna she was heavily focussed on the molecular determinants of allergy-induced effector cell activation She was able to continue this research project during her dissertation demonstrating that the extent of an allergic reaction is determined to a large extent by the number and also the position of IgE epitopes on an allergen she received a bursary under the "EMBL Interdisciplinary Postdocs" (EIPOD) programme and this enabled her to work on interdisciplinary research projects at the European Molecular Biology Laboratory (EMBL) in Hamburg Gieras is working and teaching at the Institute of Immunology at the University Medical Center Hamburg-Eppendorf where she is researching the effects of prenatal steroid treatment on immune system development Regina Selb was born in Feldkirch (Vorarlberg) in 1983 She studied microbiology and genetics at the University of Vienna between 2003 and 2010 and during her diploma project with Angela Witte at the MFPL she researched haloalkaliphilic Archaea viruses Between 2010 and 2015 she completed a PhD in immunology at MedUni Vienna She wrote her thesis at the Department of Ear Nose and Throat Diseases in an allergology working group led by Verena Niederberger-Leppin the low affinity receptor for immunoglobulin E (IgE) Regina Selb is currently working at the European Food Safety Authority (EFSA) in Parma where she is writing a new European Guideline on the allergy risk assessment of genetically modified plants for foodstuffs and animal feed We use cookies that are technically necessary for the functionality of our website marketing and analysis purposes to optimise the user experience on our site data is processed both by us and by third-party providers some of which are based in third countries (e.g You can find more information about the tools and the partners in our data protection declaration in which we also explain exactly what data transfer to the USA can mean You can individually adjust or revoke your cookie settings at any time if you wish These cookies are necessary for the basic functions of the website You can block or delete them in your browser settings but you then run the risk that some parts of the website will not function properly Necessary to obtain consent for certain cookies and thus for the use of certain tools To track users on your website(s) or app(s) the default Matomo Tracking code in JavaScript uses 1st party cookies which are set on the domain of your website.