Although Easter Sunday remains more than a month away markets at which eggs and springtime décor take center stage are already beginning to pop up across Europe Such events offer not only the chance to acquire thoughtfully crafted items but also to explore what are oftentimes beautiful and historically significant settings Some particularly well-set markets take place in the following environs: Other monasteries that host Easter markets include Seligenstadt (March 8-9) Maulbronn (March 22-23) and the Dominikanerkloster in Frankfurt am Main (March 22-23) masked balls and elaborate parades are all part of Fasching festivities Commonly known as Mardi Gras in the States Fasching celebrates the few remaining days before the solemn season of Lent parades and parties are usually held on Rose Monday (Rosenmontag) or Shrove Tuesday Here are a few upcoming events for revelers wanting one last shot of indulgence and debauchery: Join the festivities of one of the oldest Fasching processions in Germany This lively parade winds its way through the charming streets of Nuremberg’s city center bands and raucous performers fill the streets of Mainz on Rosenmontag The highlight of the carnival season in Mainz the Rose Monday parade can take as long as five hours to pass through the streets Keep an eye out for sweets and other treats thrown into the festive crowds the Wiesbaden Carnival parade will kick off at precisely 1:11 p.m music and beautiful floats as they pass by The party continues long after the parade has finished This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page In order to operate and optimise our website we would like to collect and analyse statistical information completely anonymously Will you accept the temporary use of statistics cookies You can revoke your consent at any time in our privacy policy This year marks the 13th awarding of the Langen Junior Science Award by the Paul-Ehrlich-Institut and the Association for the Promotion of the Langen Science Award Samuel Theuerkauf (30) received first prize for his research on improving gene transfer using two markers The second prize went to Dr Yen-Ju Lin (35) for her research on the influence of artificially generated fusion proteins on the immune system The third prize went to Dr Moritz Schüssler (33) for his research on the influence of the restriction factor SAMHD1 on HIV-1 infections The Junior Science Awards recognise high-calibre research leading to first author publications in recognised journals The three prizewinners received their certificates and congratulations on 15 April from the Chairman of the Association for the Promotion of the Langen Science Award Acting President of the Paul-Ehrlich-Institut member of the Sparkasse Langen-Seligenstadt Management Board Managing Director of Stadtwerke Langen GmbH (Langen Utility Company) First City Councillor Stefan Löbig conveyed the city's congratulations: "It is a pleasure for us to be able to support young and talented scientists every year with the Junior Science Award The city of Langen is once again demonstrating its commitment to research and teaching We would like to express our thanks to the Sparkasse Langen-Seligenstadt for funding this important prize again this year." High-calibre research in all areas relevant to the medicinal products in the Paul-Ehrlich-Institut's area of responsibility is an integral part of the activities of the Federal Institute for Vaccines and Biomedicines "The fact that the prizes have been awarded in research areas so varied as gene transfer and allergy immunotherapy shows how diverse our research is in connection with our regulatory tasks," stated Institute President Vieths First prize went to Samuel Theuerkauf for his first author publication titled "AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery" The aim of his research is to optimise gene transfer precisely into therapy-relevant cells of a specific disease It is already possible to modify non-pathogenic viruses – acting as gene shuttles – to target certain cells such as immune T cells but the vectors only recognise the targeted cells on the basis of one marker Many therapy-relevant cells in the human organism are only clearly defined by the combination of several markers In the case of chronically HIV-infected cells it is the combination of the markers CD4 and CD32a The research project involved the first ever modification of adeno-associated viral vectors (AAVs) to carry two different high-affinity binders (DARPins; designed ankyrin repeat proteins) one specific for CD4 and the other for CD32a These bispecific AAVs transduced CD4/CD32a double-positive cells with much higher efficiency than single-positive cells and even reached the double-positive cells when they were present in minimal amounts in cell mixtures or human blood The clear preference for double-positive cells was also confirmed in vivo in a mouse model with a small number of double-positive cells in the bone marrow of the animals After systemic application of the vector particles Cell entry studies showed that bispecific AAVs enter cells more efficiently than monospecific ones when the vectors were equipped with a CRISPR/Cas cassette targeted to the HIV genome they prevented HIV replication in T cell cultures This research is the first proof of concept for high-precision and efficient gene transfer through tandem-binding domains on AAVs This presents a new option for receptor-controlled vectors to improve the specificity and safety of in vivo gene therapy Dr Yen-Ju Lin received the second prize for her first author publication titled "A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages" Lin investigated how therapeutics against birch pollen allergies can affect the immune system The recombinant fusion protein rFlaA:Betv1 consists of two genetically composed components: flagellin A which is needed by bacteria for their locomotion system and is an activation signal for immune cells an allergen responsible for birch pollen allergies the research group had already shown that the administration of rFlaA:Betv1 can stop the development of birch pollen allergies in the mouse model Studies had also shown that certain types of immune cells – macrophages – are partly responsible for the reduced allergic reaction by releasing anti-inflammatory messenger substances (cytokines) Lin and the research group have now further investigated the mechanisms underlying the activation of macrophages by the fusion protein By combining different mutants of the fusion protein using inhibitors that block immunological processes and using cell lines lacking certain parts of the immune system they found that activation of macrophages by the fusion protein was mediated via two receptors of the innate immune system They are known to trigger the formation of an inflammasome a multiprotein complex of the immune system which in turn mediates the release of cytokines and inflammatory responses The research is a contribution to a better understanding of how therapeutics that combine antigen and adjuvant in a single molecule activate the immune system so that they can be used safely and effectively in the future not only for allergy immunotherapy but also for the treatment of other diseases The third prizewinner is Dr Moritz Schüssler He was recognised for the first author publication titled "Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation Schüssler and his colleagues researched the role of the protein SAMHD1 (sterile alpha motif and histidine-aspartate (HD) domain-containing protein 1) in HIV-1 infections Its antiviral activity is regulated by phosphorylation at the T592 position A new methodology involved the introduction of specific mutations into the genome of these cells which allowed the connection between phospho-regulation and antiviral function to be genetically decoded The use of BLaER1 cells as a new cell model for HIV-1 infections made it possible to investigate these mutations in a physiological context The results showed that the antiviral activity of SAMHD1 and its enzymatic function are not always directly related These findings highlight the complexity of the relationship between SAMHD1 The study could open up new avenues for the development of therapies that target SAMHD1 without disrupting other cellular processes and contribute to the study of innate antiviral immunity top Christie’s upcoming Old Masters Evening Sale in London will be led by a £1.5m portrait of a praying nobleman by Hans Memling one of the artist’s earliest paintings The present painting is not only one of the last autograph works left in private hands by the great Netherlandish painter but also one of the artist’s earliest known paintings This panel appears to have originally formed the left wing of a triptych Portrait of a member of the De Rojas family !function(m,a,i,l,s,t,e,r){m[s]=m[s]||(function(){t=a.createElement(i);r=a.getElementsByTagName(i)[0];t.async=1;t.src=l;r.parentNode.insertBefore(t,r);return !0}())}(window,document,'script','https://tibet.net/wp-content/plugins/mailster/assets/js/button.min.js','MailsterSubscribe'); Tibetan spiritual leader His Holiness the Dalai Lama (R) waves next to Hesse's state Prime Minister Volker Bouffier during a visit to the monastery in Seligenstadt near Frankfurt August 22 2011.His Holiness the Dalai Lama is on a three-day visit to the German federal state of Hesse Germany: His Holiness the Dalai Lama on Monday visited Frankfurt and Wiesbaden as guest of the Hesse State Government in Germany.In a press release issued on 9 June the Hessen Secretary of State Mr Michael Busse announced that His Holiness the Dalai Lama was visiting the Hesse at the invitation of Minister President Mr Volker Bouffier and the President of the State Parliament Mr Norbert Kartmann The State Government will host a luncheon in honour of His Holiness the Dalai Lama in Seligenstadt on 22 August The Hessian Cabinet and the President of the Parliament will be present at the lunch His Holiness the Dalai Lama will address students and faculty members of Goethe University Frankfurt’s oldest university in the afternoon His Holiness will speak on Leadership and Values at the request of the University His Holiness the Dalai Lama will address members of the Parliament This address is before the start of the parliament’s plenary session after the summer break Both His Holiness the Dalai Lama’s address to the Parliament and Goethe University will be webcast live His Holiness the Dalai Lama will then attend a reception organised by Friends of a Friend Over 300 especially invited guest will be present at the reception On 24 August morning His Holiness will visit Johann-Peter Shepherd School (school for the blind and visually impaired) in Friedberg One of the student’s father requested His Holiness the Dalai Lama in 2009 to visit this special school The former Minister President Mr Roland Koch started the special relationship between the Hesse people and His Holiness the Dalai Lama and the Tibetan people Mr Koch from his university days was involved with the Tibetan issue He is a close friend and supporter of His Holiness the Dalai Lama Tibetan spiritual leader His Holiness the Dalai Lama Hesse's state Prime Minister Volker Bouffier (R) and his wife Ursula (L) pose in a pharmacy during a visit to the monastery in Seligenstadt near Frankfurt August 22 Tibetan spiritual leader His Holiness the Dalai Lama (R) shakes hands with a young girl during a visit to the monastery in Seligenstadt near Frankfurt August 22 Tibetan spiritual leader His Holiness the Dalai Lama walks through the garden during a visit to the monastery in Seligenstadt near Frankfurt August 22 His Holiness the Dalai Lama Offers Congratulations to Anthony Albanese on His Re-election as Prime Minister of Australia Sikyong Meets Current and Former Chairs of the US House Foreign Affairs Committee to Discuss Appointment of Special Coordinator for Tibetan Issue His Holiness the Dalai Lama Congratulates Canadian Prime Minister Mark Carney on His Party’s General Election Victory Speaker Khenpo Sonam Tenphel offers condolence over the demise of His Holiness Pope Francis Tibet at a Glance Tibetan National Flag Global Tibet Movement Constitution Leadership Judiciary Legislature Executive Election Commission Public Service Commission Auditor General Religion and Culture Home Finance Education Security Information & International Relations Health Issues Facing Tibet Sino Tibetan Dialogue Middle Way Approach Dolgyal-Shugden © Central Tibetan Administration • Privacy Policy • Terms of Service Halloween is their favorite holiday of the year This is primarily the case because of all the candy children get to feast on after going trick-or-treating while this secular holiday has become associated with feasting on candy it was originally a day of fasting in the Catholic Church November 1 is All Saints Day in the Catholic Church (There is no obligation this year for Catholics in the US as it falls on a Monday.) All Saints Day is a solemnity one of the highest ranked feasts in the Church For many centuries the Church was accustomed to observe the eve or vigil of a major feast day with a special fast It followed the ancient saying that you should "fast before you feast." The Catholic Encyclopedia explains a bit of the history behind this tradition In the evening the faithful assembled in the place or church where the feast was to be celebrated and prepared themselves by prayers readings from Holy Writ (now the Offices of Vespers and Matins) the bishops introduced for the laity a fast on the day before the feast .. The Synod of Seligenstadt (1022) mentions vigils on the eves of Christmas The day prior to All Saints (October 31) was observed as a day of fasting for many centuries all the way through the first half of the 20th century as is mentioned in the Catholic Encyclopedia of that era "In the United States only four of theses vigils are fast days: the vigils of Christmas It may seem strange to modern ears that Halloween was a day of fasting but Christians in previous centuries saw this day as a day to prepare their hearts for the celebration of All Saints Articles like these are sponsored free for every Catholic through the support of generous readers just like you Please make a tax-deductible donation today Help us continue to bring the Gospel to people everywhere through uplifting Catholic news a 40-day time period set aside to prepare for Easter through abstinence from certain pleasures While traditionally a season of solemnity and self-reflection a look at Europe’s cultural calendar for the weeks ahead reassures us that fun and festivity isn’t entirely off the agenda Here are some ways to get in sync with the season: associated with new life from time immemorial have long been given astounding makeovers for Easter While prettily dyed and decorated versions are ubiquitous this time of year some artists take the craft of embellishing eggs to another level Their talent and creativity is on full display at multiple Easter egg exhibitions In contrast to more generic Easter markets at which a variety of plants and handicrafts are sold egg artistry stands front and center at the following events in Germany: is considered a day set aside for rejoicing within an otherwise austere period it’s also the Sunday on which a number of Belgian communities traditionally hold their carnivals Cities and towns with some of the most charismatic of celebrations include Stavelot long-nosed Blanc-Moussis are stars of the show (online: laetare-stavelot.be/en) and Andenne where the “Carnaval des Ours” sees thousands of people in bear costumes parade through the streets and tiny bear effigies get tossed from City Hall’s balcony colorful costumes and twirling dances of the folkloric characters known as Chinels that give the carnival its special flair Other communities with Laetere carnivals include La Roche-en-Ardenne and Tournai Residents of towns throughout the Duchy of Luxembourg also mark the first weekend of Lent with massive bonfires known as Buergbrunnen or Fêtes des Brandons an attempt to put the worst of winter weather behind 20:29Lesezeit: 3 Min.Bildbeschreibung ausklappen„Glänzend erzähltes Stück Lebensgeschichte”: Margot FriedlanderRainer WohlfahrtMargot Friedlander erhält für ihre 2008 erschienene Autobiographie „Versuche dein Leben zu machen - Als Jüdin versteckt in Berlin“ den diesjährigen Einhard-Preis der Seligenstädter Einhard-Stiftung Die mit 10.000 Euro dotierte Auszeichnung wird seit 1999 alle zwei Jahre von der Einhard-Stiftung zu Seligenstadt am Todestag Einhards TeilenVerschenken Merken Drucken Anhören Schlagworte: Unterm Hakenkreuz: Wisst ihr Deutsche das? Und wie findet ihr es? Er war der einzige Emigrant der während der NS-Zeit unzensiert den Deutschen ins Gewissen sprach Thomas Manns erschütternde BBC-Reden zwischen 1940 und 1945 sind in Form und Inhalt einzigartig Jetzt sind sie in einer Neuauflage wieder zu lesen Falscher Polizist in Offenbach gefasst +++ Hessische AfD-Abgeordnete fliegen trotz Ausladung nach Belgrad +++ Motorradfahrer bei Unfall auf B84 schwer verletzt +++ Frau stürzt kopfüber mit Fahrrad +++ Liveblog für Frankfurt und Hessen Die Lieferdienste Wolt und Knuspr weiten ihre Partnerschaft aus Wolt-Kunden in Frankfurt können über die App jetzt auch im Onlinesupermarkt von Knuspr einkaufen.