Please enable JS and disable any ad blocker Tamar Warburg wants to be the first Orthodox woman in the New Jersey legislature she faces an uphill battle in her own Jewish community Like so many other Jews living in the diaspora Tamar Warburg experienced an awakening of sorts after the Oct She lives in Teaneck, N.J., where Orthodox Judaism flourishes and more than a dozen synagogues dot the suburban landscape. But when a pro-Israel resolution that came before the town council soon after Oct. 7 sparked vitriolic protests Warburg experienced the resulting tension as a “defining moment” leading to a life-changing turn to electoral politics — from a surprising rise in local party politics to a long-shot campaign this year for the New Jersey Assembly.  “I think there was always something bubbling under the surface and everything kind of bubbled up,” Warburg told Jewish Insider in a recent interview “A group of community members got together and said observed that town power brokers often got their start on a body called the Democratic Municipal Committee two of the committee’s 46 members were Orthodox Jews Warburg and Gross recruited Jewish candidates to run for the body the number of Orthodox Jews rose from two to 18, Warburg among them.  “The main motivation was flexing political muscle and saying We can vote as a bloc if we want to,’” Warburg said was to have people who are running for office I need to pay attention to them and be attentive to their needs if I want to be reelected.’”  on the ballot in the June 10 Democratic primary to represent New Jersey’s 37th Assembly district Englewood and most of Bergen County.  Now all the candidates will be listed in a bloc “I realized this was not an offer to Tamar Warburg and unless I had a really compelling reason not to do it I didn’t really have the authority to say no I knew I would work really hard at this,” said Warburg “It’s the first real primary in New Jersey in decades and the Jewish community really needs a seat at the table.” If elected, Warburg would be the first Orthodox woman to serve in New Jersey’s legislature. (There are currently two Orthodox men in the state Assembly.)  she first faces an uphill battle within her own Jewish community A messy political dispute playing out in the New Jersey gubernatorial election has trickled down to this Assembly race pitting Warburg against another Orthodox candidate Yitz Stern — and threatening to split the Jewish vote and deal a win to the incumbents.  It all started with what was intended to be a straightforward piece of legislation that would’ve formally defined antisemitism in state law affording law enforcement officers and other state employees a tool to understand and respond to hate crimes and formulate anti-discrimination policies.  “I think that the incumbents in the Assembly have simply not been responsive,” said Alan Sohn a former member of the Teaneck township council who is supporting Warburg very disappointed to see some of the lack of support among the incumbents about antisemitism.”  but it was never brought to a vote on the floor.  Of the two incumbent assembly members from District 37, one — Ellen Park — signed on as a sponsor of the bill earning criticism from many in the Bergen County Jewish community.  But what really riled up the district’s Jewish voters was the way that Fulop in an effort to assuage detractors in the Jewish community And because Warburg is running on a Fulop-aligned slate some view her stance on the issue as giving political cover to Fulop.  and only because of my affiliation with Steve my Jewish community is running another slate against me,” Warburg said “If you can’t be on the same page on IHRA then what can you actually be on the same page that actually matters more?” Teaneck Mayor Mark Schwartz told JI The IHRA bill is “the number one issue that comes up” when Warburg talks to Jewish voters even though her position on the issue is clear.  a Bergen County municipal employee who has served on local boards and commissions for several decades was considering running for the state Assembly before the IHRA brouhaha began But that was a motivating factor for his campaign “One of the reasons I did go into the race is that I was not happy with Mayor Fulop’s stance on the IHRA legislation,” Stern told JI in a recent interview although he first entered the race before Fulop’s position on the issue was known who has refused to back legislation that would codify the IHRA definition.”)  while Warburg has struggled to bring in endorsements.  “It’s very clear you can vote for the two of them But it’s running against her that feels like we didn’t learn the lesson of Oct 7 — that we’re powerful and can defend ourselves when we’re united whether it’s about permission or power “All I see is we’re dividing the vote “I’d love to see her further getting involved down the line and we will be stuck with two incumbents that have not only done nothing for our town but even less so for our Jewish community.”  The Stern camp is not alone in being worried that the campaign between the two Orthodox candidates is beginning to look like a head-to-head matchup Stern and Warburg both stand a shot at getting elected — together When voters look at their ballots for the primary they will not see the slates; they can choose any two Assembly candidates so it would be possible to vote for both Jewish candidates.  agrees that voters can select her and Stern “I am being targeted as having guilt by association with Steve [Fulop],” she said even if somebody had a problem with my association of course they could vote for Josh [Gottheimer] for governor and they could vote for me for Assembly There’s nothing preventing them from doing that and I don’t think splitting the Jewish vote serves our interests.” The Warburg campaign is distributing yard signs to supporters in a much smaller font: “Warburg and Park for Assembly.”  Copyright © 2025 · All Rights Reserved · Jewish Insider The politics and business news you need to stay up to date delivered each morning in a must-read newsletter Enter your email to gain access to our exclusive contentDon’t worry if you are already subscribed you won’t receive our newsletters twice Warburg Pincus eyes $2.4bn Fonterra consumer and retail unit amid Asia-Pacific expansion also includes Fonterra’s Oceania and Sri Lanka operations spanning milk collection The deal forms part of the dairy giant’s dual-track strategy announced in November which may result in either a trade sale or an IPO Warburg Pincus’ interest signals growing private equity appetite for branded consumer assets across Asia-Pacific driven by rising demand for dairy products in emerging markets The firm is reportedly assessing the portfolio’s scale If Fonterra proceeds with a public listing the new entity will be named Mainland Group the assets up for sale represent roughly 19% of the group’s H1 FY2024 operating earnings Source: Reuters If you think we missed any important news, please do not hesitate to contact us at news@pe-insights.com Subscribe to our Newsletter to 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Click here to register Please check your spam or junk folder just in case On the latest episode of Goldman Sachs Exchanges: Great Investors shares insights on navigating a challenging private equity landscape the firm's strategic focus on diversification and where he sees the next big investment opportunities Connecting decision makers to a dynamic network of information Bloomberg quickly and accurately delivers business and financial information The King Abdullah Financial District in Riyadh New York-headquartered Warburg and Hassana Investment Co. signed an agreement to explore investment opportunities that contribute to the long-term growth of Saudi Arabia The two firms have had a decade-long partnership in international markets Longtime professor Gerald Warburg was recruited to UVA by his daughter Growing up in a small town on the West Coast 10,000 miles away.” So he was surprised to find himself at age 21 working as a legislative assistant to House and Senate leaders After a decade and a half in the legislative branch he became disenchanted by a lack of results He began working at one of the largest government relations firms in Washington and teaching classes at Georgetown University “When I saw how outgunned a lot of environmental policy and civil rights groups were by corporate lobbies I promised myself that if I ever had the opportunity to help level the playing field But even working with nonprofits and taking on pro bono clients he felt he wasn’t serving his original mission to equip citizens for action called to say there was a new school of leadership and public policy opening at UVA “She encouraged me to meet with the incoming head of Batten,” he said “I was told there were a large number of candidates and I didn’t have a traditional academic background so I didn’t think I was serious competition.” That was 2009; he has been here ever since helping mold the Frank Batten School of Leadership and Public Policy from an idea to an institution he received the prestigious 2024 All-University Teaching Award nominated by the dean of the Batten School there are hundreds of students working on Capitol Hill and serving in local communities across the world who owe so much to him in terms of how they analyze difficult issues and engage with others whom they agree and disagree with,” said Solomon who credits Warburg for being an integral part of the Batten School’s creation and growth we were 25 students and three faculty in the old Confederate war hospital morgue,” Warburg remembered Their goal was to grow the school tenfold in the first 10 years the Batten School exceeded that ambitious goal and now has hundreds of students 36 full-time faculty supported by dozens of shared professors and adjuncts.  “The Batten community is this remarkably rich “It is exciting to be part of a team designing an institution and a vibrant program that can change and grow after the senior professors make way for the next generation.” Warburg said he has seen young people lose a bit of confidence that they can use politics to achieve results He sees it as his job to empower them to advance their political views elitist and dismissive of young voters,” he said “I want my students to be able to stand up for their principles and follow their own North Star.” That’s why he includes role-playing simulations in his class he simulated a government shutdown and had students who identify more with Democratic politics play the role of Republicans He also created a course that teaches students how to lead a nongovernmental organization after realizing many students would pursue their passions through NGO work and needed to be prepared.  “They’re going to get drafted to be the head of the PTA or the Chamber of Commerce,” he said and benefit from learning similar leadership skills that aren’t often taught.  “Equipping young women and young men who I know are going to be leaders and then seeing them rise to positions of leadership during my 15 years at UVA has been the single greatest honor of my professional life,” he said An even greater joy has been becoming a grandfather He said parenting and now grandparenting have taught him valuable skills that make him a better teacher “Not be the ‘sage on the stage,’ just maybe the ‘guide on the side.’” Cleary Gottlieb is representing Warburg Pincus in its sale of Sundyne to Honeywell International (Honeywell) for $2.16 billion in cash and is expected to close in the second quarter of 2025 The transaction values Sundyne at approximately 14.5 times its 2024 EBIDTA on a tax-adjusted basis Colorado with operations and presence in Europe Sundyne is a global manufacturer of precision-engineered safe and efficient centrifugal pumps and compressors for use in chemical It is the world leader in delivering low-flow high-head integrally geared centrifugal pumps and compressors safe and leakage-free sealless magnetic drive centrifugal pumps Sundyne pumps and compressors are available in API TRIUMPH Shareholders to Receive $26.00 in Cash Per Share RADNOR, Pa. and NEW YORK and BOSTON, Feb. 3, 2025 /PRNewswire/ -- Triumph Group, Inc. (NYSE: TGI) ("TRIUMPH" or the "Company") today announced that it has entered into a definitive agreement under which affiliates of growth-focused private equity firms Warburg Pincus and Berkshire Partners will acquire TRIUMPH through a newly formed entity for a total enterprise value of approximately $3 billion TRIUMPH will become a privately held Company jointly controlled by Warburg Pincus and Berkshire Partners TRIUMPH shareholders will receive $26.00 per share in cash The purchase price represents a premium of approximately 123% over the Company's unaffected closing stock price1 and a premium of approximately 58% over the volume weighted average price (VWAP) of TRIUMPH common stock for the 90 days prior to January 31 "We are pleased to have reached this agreement which reflects the culmination of the Board's robust process and will deliver immediate certain and premium cash value to our shareholders," said Dan Crowley TRIUMPH successfully optimized our portfolio built around a world class team and capabilities This transaction recognizes our Company's position as a valued provider of mission-critical engineered systems and proprietary components for both OEM and aftermarket customers As a privately held company in partnership with Berkshire Partners and Warburg Pincus TRIUMPH will have an enhanced ability to meet our customers' evolving needs and provide more opportunities for our valued employees." "TRIUMPH has a strong reputation as a leader in highly engineered aerospace components and systems and we are excited about partnering with them in this next chapter of growth," said Dan Zamlong "With our deep experience investing in and developing aerospace platforms we look forward to working with TRIUMPH's talented global team to increase opportunities for its portfolio and capture the growing demand for high quality aerospace components." "TRIUMPH plays a critical role in the aerospace and defense industry and is known for providing high quality products on key platforms Berkshire has a long history of partnering with market-leading aerospace companies and we look forward to helping accelerate the next phase of TRIUMPH's growth," added Blake Gottesman Timing and ApprovalsThe transaction is expected to close in the second half of calendar year 2025 and is subject to customary closing conditions including approval by TRIUMPH shareholders and receipt of required regulatory approvals TRIUMPH's Board of Directors unanimously approved the definitive agreement The transaction is not contingent upon financing TRIUMPH will no longer be traded on the New York Stock Exchange Third Quarter Fiscal 2025 EarningsIn connection with its pending transaction TRIUMPH will release its third quarter fiscal 2025 earnings and file its Form 10-Q by February 10 and is cancelling its previously scheduled earnings conference call and webcast LLC is serving as exclusive financial advisor and Skadden Meagher & Flom LLP is acting as legal counsel to TRIUMPH Lazard is serving as financial advisor and Kirkland & Ellis LLP and Covington & Burling LLP are acting as legal counsel to Berkshire Partners and Warburg Pincus About TRIUMPH Founded in 1993 and headquartered in Radnor repairs and provides spare parts across a broad portfolio of aerospace and defense systems and components The Company serves the global aviation industry including original equipment manufacturers and the full spectrum of military and commercial aircraft operators More information about TRIUMPH can be found on the Company's website at www.triumphgroup.com About Warburg PincusWarburg Pincus LLC is the pioneer of private equity global growth investing the firm has the flexibility and experience to focus on helping investors and management teams achieve enduring success across market cycles the firm has more than $86 billion in assets under management and more than 230 companies in their active portfolio Warburg Pincus has been an active investor in the aerospace & defense and industrial technology sectors with current and former investments including Accelya Warburg Pincus has invested in more than 1,000 companies across its private equity The firm is headquartered in New York with offices in Amsterdam, Beijing, Berlin, Hong Kong, Houston, London, Luxembourg, Mumbai, Mauritius, San Francisco, São Paulo, Shanghai, and Singapore. For more information, please visit www.warburgpincus.com or follow us on LinkedIn Forward-Looking StatementsThis document contains "forward-looking statements" within the meaning of the safe harbor provisions of the U.S Private Securities Litigation Reform Act of 1995 Forward-looking statements also may be included in other publicly available documents issued by the Company and in oral statements made by our officers and representatives from time to time These forward-looking statements are intended to provide management's current expectations or plans for our future operating and financial performance based on assumptions currently believed to be valid and information currently available to management They can be identified by the use of words such as "may," "might," "anticipate," "plan," "believe," "potential," "intend," "expect," "strategy," "will" and other words of similar meaning in connection with a discussion of future operating or financial performance Examples of forward looking statements include uses of cash and other measures of financial performance Because forward-looking statements relate to the future uncertainties and other factors that may cause the Company's actual results and financial condition to differ materially from those expressed or implied in the forward-looking statements the following risks: (i) the occurrence of any event change or other circumstances that could give rise to the termination of the merger agreement; (ii) the risk that the Company's stockholders may not approve the proposed transaction; (iii) inability to complete the proposed transaction because conditions to the closing of the proposed transaction may not be satisfied or waived; (iv) uncertainty as to the timing of completion of the proposed transaction; (v) potential adverse effects or changes to relationships with customers suppliers or other parties resulting from the announcement or completion of the proposed transaction; (vi) potential litigation relating to the proposed transaction that could be instituted against the Company (the "Buyer") or their respective directors and officers including the effects of any outcomes related thereto; or (vii) possible disruptions from the proposed transaction that could harm the Company's or Buyer's business Further information regarding the important factors that could cause actual results to differ from projected results can be found in the Company's reports filed or that may be filed with the SEC including our Annual Report on Form 10-K for the fiscal year ended March 31 2024 and our Quarterly Reports on Form 10-Q for the fiscal quarters ended June 30 2024.  Any forward-looking information provided in this document should be considered with these factors in mind We assume no obligation to update any forward-looking statements contained in this document Participants in the SolicitationThe Company and its directors and executive officers all of whom are members of the Company's Board of Directors Senior Vice President and Chief Financial Officer Mergers & Acquisitions & Treasurer Controller may be deemed to be participants in the solicitation of proxies from the Company's stockholders with respect to the proposed transaction Additional information regarding such participants including their direct or indirect interests can be found under the captions "Security Ownership of Principal Stockholders and Management," "Board of Directors—Director Compensation," and "Compensation Discussion and Analysis" contained in the Company's proxy statement on Schedule 14A filed with the SEC on June 24 To the extent that the Company's directors and executive officers and their respective affiliates have acquired or disposed of security holdings since the applicable "as of" date disclosed in the 2024 Proxy Statement such transactions have been or will be reflected on Statements of Change in Ownership on Form 4 Initial Statements of Beneficial ownership on Form 3 or amendments to beneficial ownership reports on Schedules 13D filed with the SEC: Form 4 with the filings of the Company on September 3 with the filings of the Company on August 12 with the filings of the Company on August 9 1of $11.65 per share as of the close on October 9 the last full trading day prior to media reports regarding a possible sale transaction Electronics and Controls announced today it has extended its agreement as a strategic supplier to.. (NYSE: TGI) ("TRIUMPH" or the "Company") today reported financial results for its third quarter of fiscal 2025 Aerospace, Defense Banking & Financial Services Acquisitions, Mergers and Takeovers Do not sell or share my personal information: Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world joining a raft of peers that have set up shop in the energy-rich region in recent years Viraj Sawhney will move to the Gulf from Mumbai to lead the firm’s deal-making efforts according to people familiar with the matter who declined to be identified as the information is confidential He will continue to oversee Warburg’s investing efforts in cross-border services including information technology and business process outsourcing deploying several offices led by its Seoul and Hong Kong teams has advised Warburg Pincus on its joint agreement with SK D&D one of South Korea’s largest multifamily operators and developers the subsidiary asset management arm of SK D&D to invest in the senior housing market in South Korea This partnership will focus on acquiring and developing senior housing for the senior population in the Greater Seoul Area The venture marks Warburg Pincus’ first investment in the living sector in South Korea and includes three strategically located assets in Seoul’s most amenitized districts The Latham team was led by Hong Kong corporate partner Richard Watkins Advice was also provided on compliance matters by Bay Area partner Christopher Frey Metrics details A new study reveals that in drastic contrast to other cancer types translocation renal cell carcinoma (tRCC) is transcriptionally rewired towards an oxidative phosphorylation (OXPHOS) state which renders tRCC vulnerable to interventions that promote NADH reductive stress highlighting how the maintenance of the optimal redox state in cancer can be therapeutically exploited Prices may be subject to local taxes which are calculated during checkout Li, J. et al. Nat. Metab. https://doi.org/10.1038/s42255-025-01218-9 (2025) Download references Laboratory of Redox Biology and Metabolism is listed as an inventor on a patent application on the therapeutic uses of LbNOX and TPNOX (US patent application US20190017034A1) Reprints and permissions Download citation DOI: https://doi.org/10.1038/s42255-025-01216-x Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research A Gerresheimer medical glassware factory in Buende The private equity firms emerged as the frontrunner after they teamed up and other potential bidders including Bain Capital dropped, the people said, asking not to be identified discussing confidential information. Shares of Gerresheimer fell about 1% as of 10:00 a.m. in Frankfurt after gaining as much as 2% earlier on Thursday. The stock has risen around 11% this year, giving the company a market value of roughly €2.7 billion ($2.9 billion). As per the regulatory filling submitted on April 28 Warburg Pincus plans to pick up a 9.99% stake by subscribing to over 81 crore compulsorily convertible cumulative preference shares of IDFC First Bank would give the firm a foothold in one of India’s rising private lenders It intends to subscribe to 43.72 crore preference shares which could slightly dilute Warburg Pincus’s final holding to 9.48% Both Warburg Pincus and ADIA have submitted that their investments will not disturb market competition or raise any regulatory concerns They argue that the deals won’t affect India’s banking sector dynamics or result in any adverse competitive impact IDFC First Bank shares have seen a mixed run across different timeframes the share price of IDFC First Bank slipped around 3% even as it posted a healthy 13% gain in the last one month its six-month performance tells a more muted story the bank’s shares have shed nearly 20% over a longer horizon With a market capitalisation of Rs 47.51 crore the stock is currently trading between its 52-week high of Rs 84.50 and a low of Rs 52.46 per share Bain Capital has requested permission from CCI to purchase a major portion of Manappuram Finance through a multi-layered deal worth Rs 4,385 crore No competition concerns have been raised as there are no overlaps between the businesses of the two companies The two investors are reportedly working with advisors on a potential full or partial sale with formal bids anticipated later this year.GHX provides cloud-based supply chain and payment management solutions for healthcare providers and suppliers Temasek acquired its stake in 2017 from Thoma Bravo which fully exited the business at that time while Warburg Pincus invested $500m in 2021 The move aligns with a broader surge in private equity exits this year Global firms have already divested nearly $119bn in assets during 2025 making it the second-largest year for exits in the past two decades Private equity firms and strategic buyers are expected to express strong interest in GHX although the outcome of the process will depend on the quality of the bids Temasek and Warburg Pincus may retain ownership if offers fall short of their valuation expectations GHX declined to comment on the potential sale but reiterated its focus on delivering technology-driven supply chain solutions to the healthcare sector both Temasek and Warburg Pincus have not commented on the ongoing process The possible sale follows a series of high-profile exits from software and healthcare technology firms exited a 90% stake in electronic health records company Modernizing Medicine in a $5.3bn deal with Clearlake Capital Other notable transactions include Thoma Bravo’s $2.4bn sale of Quorum to Francisco Partners and Blackstone’s reported plans to exit HealthEdge have been active players in healthcare and software sectors The potential GHX transaction would mark another significant milestone in their broader exit strategies amid a strong secondary market for mature technology assets The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission All content on this site: Copyright © 2025 Elsevier B.V. innovation and expand client reach in veterinary and dental markets SCOTTSDALE, Ariz., Jan. 7, 2025 /PRNewswire/ -- Mashura a leading inventory intelligence platform in healthcare today announced a $300 million strategic partnership with a newly formed financing vehicle sponsored by Warburg Pincus the pioneer of private equity growth investing Mashura will focus on expanding its customer base across the U.S innovating key solutions and increasing integration partnerships a global leader in inventory intelligence solutions provides cutting-edge smart cabinet technology to veterinary and dental clinics which drives hard dollar cost savings by streamlining operations improving inventory management and ensuring seamless compliance with DEA and state regulatory audits Mashura delivers tailored solutions designed to meet the unique needs of each market The company's software platform offers real-time reporting and intuitive analytics empowering customers to prioritize operational demands and optimize inventory supply By reducing medication costs and improving efficiency Mashura supports clinics in driving positive EBITDA With installations in over 16 countries worldwide Mashura's solutions are transforming how healthcare providers manage their inventory and improve patient outcomes "One of my core focuses is to foster a culture at Mashura that emphasizes serving one another and creating programs that enhance healthcare for both people and their pets we help healthcare companies maximize profitability thereby increasing safety and mitigating risk," said Anton Visser "This partnership unlocks an exciting new opportunity for Mashura The support from Warburg Pincus is invaluable and we look forward to leveraging their decades-long experience in healthcare and financing strategies." "Mashura is a valued part of the vet and dental markets with their innovative storage cabinets helping clients with increased billing capture automated suggested ordering and regulatory audits – all important services for healthcare providers," said José Arredondo "We are excited to partner with Anton and the CUBEX and Zimbis teams on this next phase of growth expanding the reach and services for the company to benefit customers as the demand for automation solutions continues to accelerate," added Jordan Jones The equity for the transaction is being provided by Warburg Pincus Capital Solutions Founders Fund ("WPCS FF") which closed in September 2024 with over $4 billion in commitments Mitsubishi Corporation remains a strategic partner to Mashura Warburg Pincus LLC is the pioneer of private equity global growth investing Warburg PincusSarah Bloom, Associate Director, Communications[email protected] MashuraNeels Visser, Director of Marketing[email protected] who transitioned to a senior advisory role last month Metrics details plays a crucial role in the onset and progression of colorectal cancer (CRC) bioinformatics analysis of public databases combined with validation using clinical specimens identified the transcription factor ONECUT3 as a key regulator related to the Warburg effect in CRC silencing ONECUT3 reverses the Warburg effect and suppresses tumor growth ONECUT3 promotes tumor growth in a glycolysis-dependent manner through hypoxia-inducible factor 1α (HIF-1α) ONECUT3 does not directly regulate the expression of HIF-1α but instead inhibits its acetylation via histone deacetylase 6 (HDAC6) This deacetylation enhances the transcriptional activity of HIF-1α ultimately upregulating multiple glycolysis-related genes downstream of HIF-1α thereby driving the Warburg effect and facilitating tumor growth in CRC These findings reveal a novel mechanism by which ONECUT3 regulates the Warburg effect in CRC and suggest that targeting ONECUT3 may offer a promising therapeutic strategy for CRC which poses a significant threat to human survival and imposes a substantial economic burden a deeper understanding of the specific molecular mechanisms involved in CRC and developing targeted drugs could potentially improve the disease prognosis the specific mechanism underlying the regulation of HIF-1α in CRC is still unclear particularly regarding glucose metabolism reprogramming we demonstrated that ONECUT3 mediates HIF-1α deacetylation through histone deacetylase 6 (HDAC6) leading to the activation of HIF-1α transcription and its downstream glycolysis-related genes thereby enhancing the Warburg effect and promoting tumor growth in CRC The ONECUT3-HDAC6-HIF-1α axis represents a potential therapeutic target for modulating aerobic glycolysis in CRC A Based on the known glycolysis-related gene clusters TCGA-COAD samples were hierarchically clustered into high-glycolysis and low-glycolysis groups B Screening for differentially expressed genes in the two groups C The 127 upregulated genes were intersected with MsigDB: TF to obtain 11 transcription factors D Ranking of log2|FC| values of 11 transcription factors E Representative IHC images showed the level of ONECUT3 expression in CRC tissues and paracancerous tissues (scale bar: 50 μm) B qRT-PCR (A) and western blot (B) to detect ONECUT3 expression in colon cancer cell lines (CACO2 SW620) and normal colon epithelial line NCM460 C ONECUT3 was knocked down in HT29 and LOVO and the efficiency was verified D The results of the Seahorse XF Bioanalyzer assay showed the ECAR results after knocking down ONECUT3 in colon cancer cells E ONECUT3 was overexpressed in SW620 and COLO205 F The results of Seahorse XF Bioanalyzer showed the ECAR results after overexpression of ONECUT3 in colon cancer cells A colony-forming assay showed the proliferation of HT29 and LOVO cells after knocking down ONECUT3 B Subcutaneous xenograft model showed tumor growth after knocking down ONECUT3 (n = 5) C colony-forming assay showed the proliferation of SW620 and COLO205 cells after overexpression of ONECUT3 D colony-forming assay showed the proliferation of ONECUT3-overexpressed cells after using the glycolysis inhibitor 2-DG A After the knockdown of ONECUT3 in HT29 cells GSEA enrichment of transcriptome sequencing C qRT-PCR (B) and western blot (C) showed mRNA and protein expression of the downstream glycolysis-related enzymes of HIF-1α after knockdown of ONECUT3 D–G qRT-PCR (D) and western blot (E) showed the HIF-1α expression after the knockdown of ONECUT3; qRT-PCR (F) and western blot (G) showed the HIF-1α expression after the overexpression of ONECUT3 I HIF-1 alpha Transcription Factor Assay kit showed the HIF-1α transcriptional activity after knockdown of ONECUT3 (H) and overexpression of ONECUT3 (I) in colon cancer cells J Co-IP assay showed that there was no direct interaction between ONECUT3 and HIF-1α This suggests that ONECUT3 could enhance the transcriptional activity of HIF-1α and influence the expression of multiple downstream glycolytic enzymes but not through direct interaction with HIF-1α A Volcano plot showed differentially expressed genes (DEGs) caused by ONECUT3 knockdown HDAC6 and ELAVL1) were identified after intersection of proteins interacting with HIF-1α and ONECUT3-regulated genes (n = 438) C qRT-PCR results showed the expression of HDAC6 after knockdown of ONECUT3 in HT29 and LOVO cells D Western Blot results showed protein expression of HDAC6 after ONECUT3 knockdown E ChIP-PCR analysis revealed that ONECUT3 was specifically bound to the HDAC6 promoter region at −1158 while no significant binding was observed at the -93 region or Exon 2 F Luciferase reporter gene assay demonstrated that ONECUT3 transcriptionally regulated the HDAC6 gene A Western Blot showed HIF-1α acetylation level by detecting pan-acetylation antibody after knockdown of ONECUT3 or HDAC6 in HT29 cells B Western blot analysis revealed the acetylation level of HIF-1α following the overexpression of ONECUT3 or the HDAC6 inhibitor (ACY241) in SW620 cells C HIF-1 alpha Transcription Factor Assay kit showed the transcriptional activity of HIF-1α after overexpression of ONECUT3 or/and inhibition of HDAC6 in SW620 cells A Representative IHC image of CRC tissue microarrays The upper column showed relatively negative staining and the lower one showed relatively positive staining B Correlation analysis of ONECUT3 with the expression of HIF-1a D OS and DFS analysis of ONECUT3 in Renji cohort and DFI analysis (H) of ONECUT3 in TCGA- COAD database K Expression of ONECUT3 was significantly correlated with microsatellite status (I) ONECUT3 regulates HIF-1α deacetylation through HDAC6 which further promotes glycolysis in CRC cells and ultimately contributes to tumor progression The original figure was created with BioRender.com identified as a regulator of the Warburg effect in CRC in this study maybe a promising candidate for combination with immunotherapy to improve its effectiveness and address existing challenges in treating CRC Given the importance of HIF-1α in aerobic glycolysis we hypothesized that ONECUT3 might regulate tumor glycolytic metabolism through HIF-1α cellular assays revealed that neither the knockdown nor overexpression of ONECUT3 affected the expression of HIF-1α at the mRNA or protein levels Further investigations demonstrated that ONECUT3 regulates the transcriptional activity of HIF-1α as evidenced by the downregulation of several HIF-1α target genes (GLUT1 It is important to note that gene regulation is a complex process influenced by various transcription factors and transcription patterns can vary across different cell lines This variability accounts for why not all HIF-1α target genes were affected Co-IP assays indicated no direct interaction between ONECUT3 and HIF-1α and ELAVL1) that interact directly with HIF-1α and are regulated by ONECUT3 While HIF-1α has been extensively studied as a classic regulatory factor in signaling pathways there has been limited progress in clinical research targeting HIF-1α The discovery of ONECUT3 and its regulatory effect on HIF-1α presents significant research potential for developing new drugs targeting HIF-1α Our study indicates that HDAC6 is involved in regulating the Warburg effect in CRC through ONECUT3 providing new evidence for the potential use of HDAC inhibitors in the treatment of CRC the promotive effect of ONECUT3 on glycolysis requires more in-depth and comprehensive mechanistic studies; (2) The small clinical sample size limits its ability to represent the broader clinical population The upregulation of ONECUT3 in CRC facilitates tumor growth by enhancing the transcriptional activity of HIF-1α through HDAC6-mediated deacetylation This process activates the transcription of glycolytic genes and enhances the Warburg effect in CRC Targeting ONECUT3 and its associated signaling pathways may offer promising therapeutic avenues for CRC treatment The reagents used in this study included 2-DG (Sigma-Aldrich The primary antibodies used for IHC staining included ONECUT3 (1:200 Two investigators blinded to the clinical information assessed the scoring based on the staining intensity We extracted the expression data for the ONECUT3 gene and prognostic information from each sample in the TCGA-COAD dataset Samples with follow-up times shorter than 30 days were excluded We then performed a log2 (x + 0.001) transformation on each expression value To determine the optimal cutoff value for ONECUT3 we utilized the R package maxstat (Maximally selected rank statistics with several p-value approximations patients were categorized into high and low-expression groups We analyzed the prognostic differences between these two groups using the survfit function from the R package survival We assessed the significance of these differences using the log-rank test method Relative quantification was performed using the comparative 2–ΔΔCt method Whole-cell protein lysates were obtained using IP lysis buffer (share-bio China) supplemented with a protease and phosphatase inhibitor (share-bio The cell lysates were separated using 10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and subsequently electrophoretically transferred onto PVDF membranes The membranes were blocked with 5% defatted milk for 1 hour at room temperature (RT) hybridized with primary antibodies overnight at 4 °C and then incubated with HRP-conjugated secondary antibodies at RT for 60 min β-actin antibody was used as a loading control Immunoblots were developed using the Basic Luminol Chemiluminescent Kit (share-bio China) and the ChemiDoc Touch image system (Bio-Rad) The antibodies used were listed as follows: ONECUT3 (1:500 protein lysates obtained as described above were incubated with Pierce Anti-HA Magnetic Beads (Thermo Fisher Scientific #88836) or Pierce Protein-A/G Magnetic Beads (Thermo Fisher Scientific which were already incubated with anti-HIF1α (2 µg ab308433) or anti-IgG (as a negative control The immuno-complexes were washed thrice with TBS-T or PBS-T and then resuspended in 1× SDS-PAGE sample buffer for western blotting analysis plasmids expressing HA-tagged ONECUT3 were constructed by Shanghai Generay Biotech Co. The cDNAs encoding full-length human ONECUT3 (NM_001080488.2) with HA tag were synthesized and inserted into the pCDH-CMV-MCS-EF1-Puro vector (Generay lentiviral siRNA negative control and siRNA oligonucleotides targeting human ONECUT3 were designed and synthesized by Genepharma (Shanghai The sequences for the siRNA were as follows: siONECUT3-1: 5’-CGCTGATCGCCATCTTCAAGGAGAA-3’; HDAC6 siRNA sequence: 5’-GGACAACATGGAGGAGGACAATGTA-3’ 293 T packaging cells were used to produce lentivirus which was subsequently transfected into target cell lines with 6 µg/ml polybrene for 24 h Transfected cells used for overexpression or knockdown were selected with 5 µg/ml puromycin for 2 weeks The overexpression or knockdown efficiency of ONECUT3 was assessed using qRT-PCR and western blotting ONECUT3 or HDAC6 specific siRNA and non-targeting control (NTC) siRNA were purchased from Genepharma (Shanghai According to the instructions of jetPRIME® in vitro DNA & siRNA transfection reagent (Polyplus dilute ONECUT3 or HDAC6 specific siRNA (25 nM) or NTC siRNA (25 nM) into 200 µL of jetPRIME® buffer add the transfection mix to the cells in serum-containing medium dropwise transfection efficiency was determined by quantitative PCR (qPCR) and immunoblot analysis Relevant experiments were conducted between 24 and 36 hours after siRNA introduction Different types of cells (1 × 103 cells per plate) were seeded in 6-well plates and incubated for approximately 14 days the formed colonies were washed twice with PBS and stained with 0.2% crystal violet for 30 min Colonies larger than 100 μm in diameter were counted for each plate The Seahorse XF96 Flux Analyzer (Seahorse Bioscience USA) was used to measure the real-time extracellular acidification rate (ECAR) of CRC cells in vitro CRC cells were seeded at a density of 2–3 × 104 cells per well in an XF96-well plate and allowed to attach overnight Cells were incubated in non-buffered media under basal conditions for 1 hour they were sequentially injected with 10 mM glucose and 80 mM glycolysis inhibitor (2-deoxyglucose ECAR measurement was normalized by total protein content The experimental data was processed using the Seahorse XF96 Wave software Approximately 2 × 106 cells from both groups (Sh-OC3#1 and Sh-control) were resuspended in 100 μl of PBS and subcutaneously injected into the backs of male Balb/c nude mice (5–6 weeks old) Ten mice were randomly assigned to two groups All animal studies received approval from the Animal Care and Use Committee of Shanghai East Hospital The mice were cared for humanely by the guidelines outlined in the Guide for the Care and Use of Laboratory Animals prepared by the National Academy of Sciences and published by the National Institutes of Health We quantified HIF-1α activity by using the HIF-1 alpha Transcription Factor Assay Kit (Abcam ab133104) following the manufacturer’s instructions after extracting the nuclear fraction processed colon cancer cells were collected and the nuclear and cytoplasmic proteins were extracted by Nuclear and Cytoplasmic Protein Extraction Kit (Beyotime The samples were added to the HIF-1α transcription factor plate wells and then incubated overnight at 4 °C Diluted HIF-1α primary antibody was added to each well and incubated at room temperature for 1 hour diluted goat anti-rabbit HRP conjugate was added to each well and incubated at room temperature for 1 hour the HIF-α DNA binding activity level was measured at 450 nm using a microplate reader ChIP assays were carried out using the EZ-Magna ChIP Assay Kit according to the manufacturer’s protocols (Millipore cells were cross-linked with 1% PFA/PBS at room temperature for 10 minutes unreacted PFA was eliminated using a 10-fold concentration of glycine samples were sonicated in lysis buffer to obtain DNA fragments ranging from 200 to 1000 bp Immunoprecipitation was performed using 5 μg of ONECUT3 or IgG antibodies Primers targeting the promoter region of the HDAC6 gene were used for quantitative RT-PCR The results were presented as the relative mRNA expression calculated by comparing the delta CT values of ONECUT3-specific antibodies with IgG antibodies To evaluate the activity of the HDAC6 gene promoter processed cells and control cells were seeded into 96-well plates and co-transfected with a PTRF luciferase reporter plasmid The plasmid contained a tandem repeat of the PTRF transcriptional response element while the Renilla control reporter served as an internal control and the enzymatic activity of luciferase and Renilla was measured using the Dual-Luciferase Assay kit (Promega E1910) following the manufacturer’s protocol We conducted statistical analyses using SPSS 19.0 for Windows and GraphPad Prism 7 software (San Diego The results were reported as mean ± standard deviation (SD) and compared using a two-tailed unpaired Student’s t-test or one-way ANOVA P-value of < 0.05 was considered statistically significant Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN Aerobic glycolysis hypothesis through WNT/beta-catenin pathway in exudative age-related macular degeneration Understanding the Warburg effect: the metabolic requirements of cell proliferation Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2 NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer facilitates glucose uptake and cellular bioenergy production via NF-kappaB signaling to promote colorectal cancer progression Transcriptional regulation of the Warburg effect in cancer by SIX1 FOXK1 and FOXK2 regulate aerobic glycolysis BACH1 stabilization by antioxidants stimulates lung cancer metastasis FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway p53 and glucose metabolism: an orchestra to be directed in cancer therapy Metabolic regulation by p53 family members Multiple roles of APC and its therapeutic implications in colorectal cancer APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer Metabolic reprogramming and epigenetic modifications on the path to cancer ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model Up-regulated ONECUT2 and down-regulated SST promote gastric cell migration epithelial-mesenchymal transition and tumor growth in gastric cancer MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma Epithelial-mesenchymal transition-related micrornas and their target genes in colorectal cancerogenesis a novel mammalian member of the ONECUT class of transcription factors Type Igamma phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer Regulation of gene expression by glycolytic and gluconeogenic enzymes The role of the HIF-1alpha/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells Class I and IIa HDACs mediate HIF-1alpha stability through PHD2-dependent mechanism promotes HIF-1alpha transcriptional activity in nucleus pulposus cells of the intervertebral disc Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish Homeostatic maintenance and age-related functional decline in the drosophila ear Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Dynamic expression of the Onecut transcription factors HNF-6 OC-2 and OC-3 during spinal motor neuron development Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer The immune consequences of lactate in the tumor microenvironment Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer HIF-1 in cancer therapy: two decade long story of a transcription factor Thirty years of HDAC inhibitors: 2020 insight and hindsight HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery Histone deacetylases and their inhibitors in colorectal cancer therapy: current evidence and future considerations HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes Role of hypoxia in the control of the cell cycle Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity Resolution metabolomes activated by hypoxic environment Download references The authors would like to thank the State Key Laboratory of Systems Medicine for Cancer for providing instrumentation and some reagents related to this work This study was funded by a grant from the Natural Science Foundation of China (82260562 the Academic Leaders Training Program of Pudong Health Bureau of Shanghai (PWRd2021-09) and the Healthcare Talents Elite Program of Shanghai Pudong New Area (2025PDWSYCBJ-02) These authors contributed equally: Ruixue Huo State Key Laboratory of Systems Medicine for Cancer were in charge of overall direction and planning designed the experiments conducted the experiments and statistical analyses All authors provided critical feedback and contributed to shaping the research The authors declare no competing interests The study was approved by the ethics committee of Shanghai Jiaotong University (KY2021-120-B) Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41419-025-07457-8 Warburg’s move comes as several other large GPs have built out internal 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Not for publication, email or dissemination The Emirati investment vehicle hired Andy Pickens in New York as managing director and AI product lead He was most recently a managing director at Apollo Global Essential digital access to quality FT journalism on any device Complete digital access to quality FT journalism with expert analysis from industry leaders Complete digital access to quality analysis and expert insights complemented with our award-winning Weekend Print edition Terms & Conditions apply Discover all the plans currently available in your country See why over a million readers pay to read the Financial Times Private equity firm Warburg Pincus is pursuing a sale of a majority stake in Kestra Holdings a $117bn network of RIAs and broker-dealers according to sources with knowledge of the situation A source told Citywire that Warburg Pincus has retained Evercore to serve as its investment banker for the sale process.  Warburg Pincus and Evercore did not respond to requests for comment by press time Metrics details Advances in cancer biology have highlighted metabolic reprogramming as an essential aspect of tumorigenesis and progression recent efforts to study tumor metabolism in vivo have identified some disconnects between in vitro and in vivo biology to the simplified nature of cell culture models and highlights a growing need to utilize more physiologically relevant approaches to more accurately assess tumor metabolism we outline the evolution of our understanding of cancer metabolism and discuss some discrepancies between in vitro and in vivo conditions We describe how the development of physiological media in combination with advanced culturing methods can bridge the gap between in vitro and in vivo metabolism understanding metabolic reprogramming in cancer can lead to important insights into the underlying pathophysiology of this disease Glucose metabolism fuels several biosynthetic and energy-generating pathways (red) Glycolytic intermediates can be re-directed from glycolysis to other biosynthetic pathways supporting DNA and RNA synthesis (pentose phosphate pathway) glycan generation (hexosamine biosynthesis) or one-carbon metabolism (serine biosynthesis) Pyruvate entry to the TCA cycle results in both high levels of ATP generation and biosynthesis pathways such as fatty acid synthesis and overall metabolic pathway engagement can be significantly altered depending on the model system and growth conditions used to investigate the cancer cells This review highlights recent advances in metabolic reprogramming in cancer focusing on bridging the gap between in vivo and in vitro studies of cancer metabolism samples are obtained and processed using mass spectrometry to identify the abundance of various metabolites individual metabolites are readily identified and differences in the sizes of different metabolite pools can be identified (shown here by the size of various circles) While more sophisticated analyses can be used to model the activity of various metabolic pathways metabolomic studies cannot directly assess pathway activity B Stable isotope tracing requires the addition of a mass-labeled metabolite (e.g. 13C-glucose,15-N-glutamine) to the system (represented here by blue overlays of various models) samples are obtained and processed for mass spectrometry This technique provides a greater depth of information regarding the utilization of different nutrients and metabolites by incorporating labeled atoms into different metabolites (represented here by blue shading of circles) This mutation produces a neomorphic metabolite R-2-hydroxyglutarate which can be distinguished from the non-mutated IDH product α-ketoglutarate providing a diagnostic characteristic to identify this mutation and highlights the utility of metabolomics as an investigational and clinical tool provides important information on nutrient supply and relative metabolic activity within tumors Stable isotope infusions into patients at the time of a biopsy or resection generate important insights into bona fide human tumor metabolism these studies demonstrate potential disconnects between model systems that can have important implications for our understanding of tumor metabolism and highlight the need to consider how we investigate metabolism in these systems carefully the choice of culture system depends on the experimental question being posed Interrogating metabolism with 2D culture can be sufficient from an experimental perspective in many aspects but can be difficult to extrapolate to more complicated systems in others Pushing the capacity of these models to mirror in vivo biology requires multiple investigational approaches and one important consideration is using culture media that more accurately represents the in vivo nutrient environment of the tumor biological fluids such as plasma were common practice for culturing cells This natural media period continued until the development of BME in 1955 This was shortly followed by the rapid generation of other synthetic media designed for different cell types that have now become standard for in vitro work today a recent physiologic media revolution initiated in 2015 with SMEM has ushered in a new wave of media development modeling in vivo environments dialyzed) of fetal bovine serum (FBS) are also important considerations and differ across these formulations with HPLM utilizing 10% dialyzed FBS and Plasmax requiring 2.5% FBS the metabolites included in this formulation were based on commercial availability and stability Defining the TIF nutrient concentrations in specific tumor types or the interstitial nutrient metabolome of healthy tissues Using a media that mimics both the concentration and availability of metabolites in vivo can significantly alter the metabolism of cultured cancer cells Several studies have demonstrated that culturing cancer cells in physiological media can better recapitulate the metabolic phenotype of tumors in vivo thoughtful consideration of the FBS supplement and percentage should be included in the experimental design While the use and advances in these platforms are rapidly accelerating several technical hurdles (image resolution these techniques offer exciting future opportunities to investigate metabolic differences in situ scientists and clinicians can better leverage tumor-specific metabolic derangements for patient benefit Advancing spatial techniques to better understand intratumoral heterogeneity and cell-cell crosstalk Continuing development of additional physiologic media to better characterize the effects of different in vivo environments such as metastatic organs Investigating cancer metabolism directly in patients The hallmarks of cancer metabolism: Still emerging Metabolic requirements for cancer cell proliferation The metabolism of cancer cells during metastasis Fighting in a wasteland: deleterious metabolites and antitumor immunity Otto Warburg’s contributions to current concepts of cancer metabolism The Warburg effect: a signature of mitochondrial overload The Warburg Effect: How Does it Benefit Cancer Cells Observations on the carbohydrate metabolism of tumours History of the Pasteur effect and its pathobiology [The biological oxidation and glycolysis in tumors] Oxidative metabolism of neoplastic tissues The multifaceted contributions of mitochondria to cellular metabolism Evolution of Mitochondria as Signaling Organelles Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step Understanding the Intersections between Metabolism and Cancer Biology Applications of metabolomics to study cancer metabolism Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML Metabolic pathway analysis using stable isotopes in patients with cancer Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM) Metabolic Heterogeneity in Human Lung Tumors Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation Metabolism of [U-13 C]glucose in human brain tumors in vivo Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies and amino acids within human triple-negative breast cancer Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein Bezwada, D. et al. Mitochondrial metabolism in primary and metastatic human kidney cancers. bioRxiv, https://doi.org/10.1101/2023.02.06.527285 (2023) Slow TCA flux and ATP production in primary solid tumours but not metastases Breast cancer cells rely on environmental pyruvate to shape the metastatic niche Extracellular metabolic energetics can promote cancer progression Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context Glutamine deprivation triggers NAGK-dependent hexosamine salvage Hyaluronic acid fuels pancreatic cancer cell growth Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism Modelling cancer metabolism in vitro: current improvements and future challenges Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions Bioprinted Multicomponent Hydrogel Co-culture Tumor-Immune Model for Assessing and Simulating Tumor-Infiltrated Lymphocyte Migration and Functional Activation The specific amino acid requirements of a human carcinoma cell (Stain HeLa) in tissue culture Amino acid metabolism in mammalian cell cultures The specific amino acid requirements of a mammalian cell (strain L) in tissue culture Cell Culture Medium Formulation and Its Implications in Cancer Metabolism Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase Improving the metabolic fidelity of cancer models with a physiological cell culture medium Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth Tumor interstitial fluid analysis enables the study of microenvironment-cell interactions in cancers Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability CRISPR screens in physiologic medium reveal conditionally essential genes in human cells Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma The impact of physiological metabolite levels on serine uptake Physiological Media in Studies of Cell Metabolism The Effect of Oxygen and Micronutrient Composition of Cell Growth Media on Cancer Cell Bioenergetics and Mitochondrial Networks Physiological Cell Culture Media Tune Mitochondrial Bioenergetics and Drug Sensitivity in Cancer Cell Models Rapid nutrient depletion to below the physiological range by cancer cells cultured in Plasmax Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma Spatial metabolomics: from a niche field towards a driver of innovation Download references and members of the Faubert Laboratory for their comments and critiques Download citation DOI: https://doi.org/10.1038/s44324-024-00017-2 Nagarro provides digital engineering services for industries including automotive potentially adding to the strong momentum of dealmaking in the country The US-based firm is working with advisers on a proposal to take Nagarro private asking not to be identified discussing confidential information Deliberations are ongoing and Warburg could decide against making an offer Other buyout firms have also previously looked at Nagarro Independent global specialty re/insurance broker McGill and Partners has been included in a US$2.2 billion multi-asset continuation fund created by private equity firm Warburg Pincus This is the first fund of its kind for Warburg Pincus a cornerstone investor in McGill and Partners since 2019 The continuation fund comprises a diversified portfolio of companies that have demonstrated significant success and growth potential Get the latest reinsurance news direct to your inbox twice a week. Sign up here Inclusion in the fund reflects McGill and Partners' development and the appeal of its business strategy which focuses on talent acquisition rather than business acquisitions The move also underscores the strength of its partnership with Warburg Pincus and highlights the firm's growth trajectory since its inception in 2019 describing it as recognition of the firm’s progress and the potential for continued growth “As the fastest-growing global specialty firm in the industry we are excited by the incredible prospects for further growth which has been recognized by the high-quality investors in this prestigious continuation fund We look forward to continuing to partner with Warburg Pincus as we go from strength to strength,” McGill said Since Warburg Pincus’s initial investment McGill and Partners has expanded significantly now operating 11 offices across three continents with over 550 employees Each employee holds an equity stake in the business which will remain in place following the fund’s closing The continuation fund’s structure is designed to maximize value for participating companies while aligning with the long-term growth goals of Warburg Pincus Earlier this year, McGill and Partners announced plans to expand into the Nordic region with the opening of a new branch office in Sweden The company explained that the move is part of its broader strategy to enhance its capabilities across key specialties and strengthen its position in the European market Please feel free to share your comments below Get the latest reinsurance news direct to your inbox twice a week. Sign up here Feb 6, 2025 | News | 0 comments The fund closed in August 2024 with more than $4bn in commitments—over double its initial target It has been a major vehicle for strategic capital solutions in the private equity sector Backed by leading global institutional investors including a wholly owned subsidiary of the Abu Dhabi Investment Authority (ADIA) the fund was designed to provide flexible financing solutions to high-growth companies Warburg Pincus CEO Jeff Perlman highlighted the milestone as a testament to the firm’s ability to identify attractive opportunities in structured transactions He credited the firm’s sector expertise and sourcing network as key drivers behind the fund’s success ADIA’s Executive Director of Private Equities emphasized the fund’s role in offering tailored capital solutions to strong businesses with clear growth trajectories The fund has already made nine investments across various industries Warburg Pincus’ Capital Solutions team consists of five managing directors with over 20 years of investing experience each The team works alongside the firm’s 280 investment professionals and 75+ value creation executives This collaborative approach has been crucial in sourcing and executing differentiated private equity deals across Warburg Pincus’ global industry verticals As the private equity landscape continues evolving the fund positions Warburg Pincus as a leader in structured capital solutions leveraging its scale and expertise to support high-quality businesses Source: PR Newswire If you think we missed any important news, please do not hesitate to contact us at news@pe-insights.com EBRD eyes €25m commitment to Provectus SEE Fund II targeting Southeast European SMEs The European.. 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The private equity firms are discussing paying $26 per share for the Radnor who asked to not be identified because the details are private A deal could be announced as soon as Monday No final decision has been made and discussions could fall through have been through large secondaries processes in the past and are more familiar with how it works ShareThe Warburg Institute: the Hamburg library that escaped the Nazis and was reborn in LondonIn 1933 a collection of 60,000 art-historical tomes was shipped to England by steamer ‘the world’s weirdest library’ has reopened after a £14.5-million transformation The reading room of the Kulturwissenschaftliche Bibliothek Warburg Inside an unremarkable 1950s red-brick building in Bloomsbury — London’s academic heartland — lies what has been described as ‘the world’s weirdest library’ and it houses nearly 400,000 books dedicated to the study of the transmission of symbols from antiquity to the Renaissance — with a reputation for focusing on the esoteric Had Dan Brown’s fictitious Harvard professor of symbology Rows of steel shelves underneath fluorescent lights are arranged over floors named ‘Word’ ‘Image’ and ‘Orientation’ Each book is sorted according to a unique system called the ‘law of the good neighbour’ below and on either side are supposed to inspire serendipitous paths of thought The library at the Warburg Institute in London where books are sorted according to a unique system called the ‘law of the good neighbour’ in the ‘Prophecy of Divinatory Practices’ section books about fortune-telling are surrounded by texts on comets Others have labels such as ‘Pilgrimage’ ‘Monasticism’ and ‘Mysticism’ ‘Aby Warburg said the book you need is always next to the one you’re looking for,’ explains Bill Sherman a professor of cultural history and the institute’s director since 2017 For the past six years he’s been overseeing a £14.5-million transformation of the Warburg — a delicate balancing act between maintaining the institute’s eccentricities and making it a centre fit for modern study at the age of 13 he sold his first-born rights to his brother in return for all the books he ever wanted By 1888 he was living in Florence, scrutinising the pagan roots of Botticelli’s motifs This study of decoding symbols and tracing their evolution developed into a field he named ‘iconology’ In 1904 he acquired an assistant to begin cataloguing his collection of 3,500 books and within a decade — inside his Hamburg home — he had established ‘a working laboratory’ for scholars which was listed on the country’s inter-library loan network Warburg was plagued by bouts of depression and psychosis under the direction of the art historian Fritz Saxl he spent a small fortune creating a purpose-built Panel 39 of Aby Warburg’s incomplete magnum opus Director Bill Sherman with a visitor in the Kythera Gallery at the Warburg Institute in front of a panel from the Bilderatlas Mnemosyne Warburg died in 1929, before he could finish his magnum opus, the Bilderatlas Mnemosyne — an attempt to synthesise the transmission of potent symbols through cultures by pinning networks of thousands of images across more than 60 giant wooden panels Following book-burning rallies, and on account of the faith of the institute’s founder and scholarly circle, the Warburg Institute’s work became impossible. In 1933, with the aid of the industrialist and collector Samuel Courtauld were shipped by steamer to safety in London Warburg’s family signed the institute over to the University of London in return for securing — and funding — its future The reception area at the Warburg Institute in London The building has just undergone a £14.5-million refurbishment the judge ruled that the deed was iron-clad and from that decision came £9.5 million the core of the budget for the recent redevelopment Dubbed the ‘Warburg Renaissance’, the overhaul — led by Stirling Prize-winning architects Haworth Tompkins whose previous clients include the Royal College of Art and the London Library — has seen the building’s old courtyard turned into a modern climate-controlled reading room for special collections and the photography archive A filing drawer from the Warburg Institute’s photographic collection the stacks have been reworked to their original form ‘We’ve undone a number of things that happened in the 1980s and 1990s We had these long tunnels of books with no natural light so they’ve been restored to the former layout and in almost every case you can see a window now,’ says Sherman The library’s novel organisational system has also been tidied up and two got spread out over multiple floors I’ve reinstated the purity of each.’ Art historian Sir Ernst Gombrich at the Warburg Institute where he served as director from 1959 to 1976 ‘You want to keep the feeling of what made somewhere special,’ says Sherman ‘But it was a very analogue institution.’ where is the new blood he hopes to draw to the Warburg going to come from ‘It’s a research institute and most of its activities are academic and those are still the core,’ he says ‘But through areas of cultural activity we’re hopefully introducing what the place has to offer to a much wider range of people ‘Artists and curators have secretly used the Warburg for research for decades I recently did an event at a gallery where an artist said to me I lied in order to gain access to the Warburg!” I don’t want people to have to lie anymore a weekly newsletter delivering our top stories and art market insights to your inbox Memory & Migration: The Warburg Institute 1926-2024 is at the Warburg Institute in London until 20 December, followed by Tarot — Origins & Afterlives Tangled Paths: A Life of Aby Warburg was published by Reaktion Books in March 2024 Warburg Pincus has USD 86bn in assets under management (AUM) and pursues a global growth investment strategy The firm has been active in Asia for 30 years Jeffrey Perlman has spent much of his 18-year tenure with the firm in Asia oversaw private equity activity in Southeast Asia and built out the real estate business across the region This is his first interview since becoming CEO in September Q: Succession planning is difficult in private equity Now you are installed as the third generation of leadership in 60 years A: There were three key elements that helped deliver a seamless transition it was a well-thought-out process that started early and was communicated clearly over time – both internally and externally now the firm’s Chairman] and his generation of leadership were selfless  Despite growing AUM by 10x during his tenure that group of senior partners did not try to monetize the enterprise value that had been created for institutions to succeed over the long term ownership must be transient; it needs to reside with the people who are there every day sourcing deals and ultimately monetizing and exiting deals and it’s been incredibly energizing for the firm the leadership transition reflects the rich history and culture of the firm strategically aligned around our investor-first private partnership Q: Is it also significant that you and Chip were both relatively young when you became CEO A: That was partly foresight on the part of the founders – trying to enable continuity over a long period of time and avoid what could be more frequent messy transitions I guess you can say I have a long runway as a part of the current generation of leadership you need a global gene and a global perspective There’s no better way to get that than living and investing outside of your home market Business building experience is also important Asia is a challenging market – you need a local presence in different markets to be successful Chip set up the business in Asia and then I developed some parts of it later on Q: Yet you’ve come into the role as an extended period of benign economic conditions is ending… the first 25 years saw declining interest rates and the following 15 were characterised by very low rates this big industry secular tailwind is starting to reverse and rates are likely to stay higher for longer (though not so high by historical standards) When you look at how top-quartile private equity firms have manufactured returns over the past decade two factors will become increasingly important: being earnings growth-focused and being diversified and we’ve been that way on both fronts for nearly 60 years A: While it’s difficult to predict the future one thing we can control is building a diversified portfolio across sector any dollar not invested in the US and tech may have been viewed as a dollar not well spent But that may not necessarily hold true in the decade to come which is why a long-term diversified strategy is so important Goldman Sachs recently projected that the S&P 500 will return just 3% annually over the coming 10 years we expect two-thirds of the global growth to come from Asia during this period We’ve seen a growing lack of persistence across the industry with big swings in performance from vintage to vintage for many GPs This is partly because diversification had fallen out of vogue but now investors are seeing the benefits of it again can keep delivering consistent and persistent returns We’ve been a net capital provider to our investors in nine out of the past 10 years returning more capital than we have invested Q: How do geopolitics and global dislocation impact diversification efforts A: We must all be cognizant of geopolitics Global Growth XIV [which closed at USD 17.3bn in 2023] but the composition of that exposure is different from the previous flagship funds If some of those variables are resolved in the coming years for example – the macroeconomic environment and some of the political dynamics are working in their favour so the flywheel for investment is very positive Q: How high is the bar for investing in China right now A: China remains a massive economy with vast entrepreneurial talent Throughout our 30 years on the ground there we have constantly adapted our investing approach to the market we have identified three key pillars that are critical to our success in the new paradigm Any new investment must be aligned with the long-term domestic policies in China; we must believe that any exit is likely going to a domestic buyer in the event foreign buyers don’t re-emerge with scale; and we need an element of control or very meaningful governance which enables us to exert influence during our hold period to allow for value creation and for our eventual exit one of our recent investments is in an affordable rental housing joint venture that has assembled a portfolio of about 30,000 apartments in Shanghai It meets the bar in terms of aligning with China’s long-term policy the exit is most likely to be domestic insurance companies Q: How do you address the fact that so much capital remains tied up in China notably minority investments in consumer internet assets A: To get investors interested and focused on China When I started our business in Southeast Asia I used to say that you could keep a mediocre business funded in China given the depth of capital in the market There are a lot of country funds that are on Fund III but haven’t delivered 1x DPI out of Fund I We have less exposure to consumer internet than many others and we’ve sent back more money than we’ve invested in China on a historical basis Of the USD 11bn we realized globally last year USD 3bn came from Asia – USD 1bn from India We’ve been good at realizing when it is time to monetize an asset in part because of our experience with Asia’s more compressed business cycles over time You must take money off the table when you can because exit windows can be shorter than in other markets Q: Would it be fair to say you are pivoting to developed Asia A: We find that investors want to play Asia in a more diversified way and that has impacted how we construct our platform in the region and there are opportunities for private equity to expand beyond emerging Asia on the back of that I thought it was important to centralize our leadership in Asia who has run our India business for over a decade and co-leads financial services globally is now running private equity for the region we made an important hire with Tak Murata as our co-head of Asia real estate and head of Japan to open the Japan office and build out our team there  Tak is a unique talent in that he comes from both private equity and real estate background a partner in our tech investing practice in New York to relocate to Singapore to lead our Technology Investing in Asia The tech opportunity in Asia is evolving from B2C consumer internet to something that resembles that in the US This trend was more evident in the mature markets – Japan and Australia – but now we see it in India and China as well Andrew is one of three senior professionals we’ve sent from the US While some of our peers have started to lean out of Asia I want to cement our franchise there for the next 20 years Q: Warburg Pincus runs companion funds alongside the global flagship funds A: The main purpose of each companion fund is to preserve the diversification of the main fund it generates meaningful alpha for investors by bringing exposure to the underrepresented or under-allocated regions or sectors The financial services sector is a good example While financial services make up 20% of the global economy only 2% of the dollars raised in private equity over the last decade have been invested in this sector It’s a less competitive area where our firm has built a strong track record Energy transition is not currently an area that is creating a diversification issue for the main fund you could make a separate argument that a different risk-reward should be associated with those deals Others have raised dedicated vehicles for energy transition on that basis Warburg Pincus closed its debut capital solutions fund on USD 4bn What is the strategy in terms of expanding into new verticals A: As a pioneer of global growth investing we have created a sizable deal engine globally across our over 270 investment professionals Along with our best-in-class firm infrastructure this has allowed us to organically extend into adjacencies leveraging our expertise in managing different risk-return profiles and deepening our partnerships with our investors any adjacency must leverage the deal engine reflect the risk-return profile our investors are looking for and the economics should be accretive to our partnership It’s also worth noting that one of the benefits of being a private partnership is that we have full control over our own strategy; there is no pressure to expand into new verticals and products just for the sake of AUM growth We believe our inaugural capital solutions fund was met with strong support from investors – despite a challenging fundraising environment – because of our differentiated approach Our capital solutions team collaborates with domain experts across our core sectors and geographies to extend our prospecting efforts and assist with structuring Q: Does that mean you would be philosophically opposed to going public A: If I ever felt we would be at a competitive disadvantage by not being public we have been one of the few truly integrated global private partnerships with an investor-first model our investors and our portfolio management team form a perfectly aligned triangle One of the challenges of being listed is that it introduces a fourth party into the triangle and that fourth party is looking for AUM growth and an ever-higher share price It will be interesting to see how this dynamic plays out across the industry The notion of separate carry for the team and fees for the few who own the management company does seem like it will create alignment issues over the longer term We feel strongly about the model we have and the success it has brought us in part because large – often listed – managers engage in M&A A: Our single biggest asset is the human capital that helps to deliver such a robust and compelling deal engine for the firm The adjacencies we are focused on also leverage that great deal engine While there might be interesting opportunities that could enhance our overall platform and lead us to look at something inorganically we continue to remain pretty focused on our core pillars of strength and our investor-first model Jeffrey Perlman will be doing a keynote interview at the AVCJ Private Equity Forum 2024 on November 19. 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For more information, please review our Privacy Policy Do Not Sell or Share My Personal Information (Opt-Out) Private equity investors Warburg Pincus and Kelso & Company are seeking to exercise a right to sell down a combined 20% stake in Somers Re as they look to reduce their stakes in the Bermuda Class 4 carrier You have reached the limit for gifting for this month Insurance Insider is the premier intelligence solution for the London and global (re)insurance markets Accessibility | Terms of Use | Privacy Policy | Cookie Policy led by Warburg Pincus' Capital Solutions team to drive next phase of innovation and expansion 2024 /PRNewswire/ -- Miami International Holdings a technology-driven leader in building and operating regulated financial markets across multiple asset classes today announced a $100 million investment from Warburg Pincus Warburg Pincus may expand its investment in MIH to support additional growth The growth investment will accelerate the next phase of MIAX's global expansion as it executes on its strategy of building a diversified revenue stream across multiple asset classes and geographies the investment will fund the construction and fit-out of a physical trading floor in Miami MIH's fourth national securities exchange for trading U.S MIAX Sapphire will operate both an electronic exchange and physical trading floor The electronic exchange successfully launched on August 12 with the trading floor in Miami scheduled to go live in 2025 MIAX Sapphire will be the first national securities exchange to establish operations in Miami The new trading facility will include a next-generation trading floor ancillary office space for MIAX employees and market participants conference facilities and broadcast media space "We are pleased to welcome Warburg Pincus as a strategic partner and look forward to leveraging its highly respected expertise and deep network of relationships in global financial services Together with our exchange member firms we believe we have assembled a group of the top financial partners in the world," said Thomas P "The investment will provide MIH with additional funding to expand strategic partnerships in financial futures and proprietary products and will also provide capital to pursue acquisitions in the U.S and internationally to accelerate our continued growth." The investment will also support further growth and expansion of MIH's agricultural and financial futures businesses on its two U.S Minneapolis Grain Exchange (MGEX) and MIAXdx including the development of new matching engine and clearing technology using MIH's proprietary technology the investment will fund the Company's expansion plans into international markets including the development and trading of new proprietary and other financial products "Tom Gallagher and the leadership team at MIAX have successfully engineered a technology-driven family of exchanges that set a new standard of reliability and excellence in the U.S along with ample dry powder to help support future growth reflects our confidence in MIAX's potential," said Gaurav Seth "We are thrilled with MIAX's progress to date and excited about the significant opportunities for MIH." "Our investment provides capital at a pivotal moment for MIAX," said Lee Becker Managing Director and member of the Capital Solutions team at Warburg Pincus collaborative relationships with leading market participants this investment supports our conviction in the entire MIAX management team and its strategy to drive continued growth and expansion across multiple asset classes in the exchange space." Lee Becker will join the board of directors of MIH Vice President at Warburg Pincus and member of the Capital Solutions team acted as financial advisor to MIH and Broadhaven Capital Partners acted as financial advisor to Warburg Pincus in connection with the transaction LLP served as financing counsel to Warburg Pincus and Cleary Gottlieb Steen & Hamilton LLP served as financing counsel to MIH Briody & Butler serves as corporate counsel to MIH Appleby (Bermuda) Limited served as special financing counsel in Bermuda to Warburg Pincus and BeesMont Law Limited serves as legal counsel in Bermuda to The Bermuda Stock Exchange (BSX) owns Miami International Securities Exchange Ledger X LLC d/b/a MIAX Derivatives Exchange (MIAXdx™) The Bermuda Stock Exchange (BSX™) and Dorman Trading MIAX Emerald and MIAX Sapphire are national securities exchanges registered with the Securities and Exchange Commission that are enabled by MIAX's in-house built MIAX offers trading of options on all four exchanges as well as cash equities through MIAX Pearl Equities™ The MIAX trading platform was built to meet the high-performance quoting demands of the U.S options trading industry and is differentiated by throughput MIAX also serves as the exclusive exchange venue for cash-settled options on the SPIKES® Volatility Index (Ticker: SPIKE) a measure of the expected 30-day volatility in the SPDR® S&P 500® ETF (SPY) MGEX is a registered exchange with the Commodity Futures Trading Commission (CFTC) and offers trading in a variety of products including Hard Red Spring Wheat Futures MGEX is a Designated Contract Market (DCM) and Derivatives Clearing Organization (DCO) under the CFTC providing DCM and DCO services in an array of asset classes MIAXdx is a CFTC regulated exchange and clearinghouse and is registered as a DCM and Swap Execution Facility (SEF) with the CFTC vertically integrated international securities market headquartered in Bermuda and organized in 1971 BSX specializes in the listing and trading of capital market instruments such as equities Dorman Trading is a full-service Futures Commission Merchant registered with the CFTC MIAX's executive offices and National Operations Center are located in Princeton Dorman Trading offices are located in Chicago To learn more about MIAX visit www.miaxglobal.com To learn more about MGEX visit www.miaxglobal.com/mgex To learn more about MIAXdx visit www.miaxdx.com To learn more about BSX visit www.bsx.com To learn more about Dorman Trading visit www.dormantrading.com About Warburg Pincus Warburg Pincus LLC is a leading global growth investor The firm has more than $83 billion in assets under management The firm's active portfolio of more than 225 companies is highly diversified by stage Warburg Pincus is an experienced partner to management teams seeking to build durable companies with sustainable value Warburg Pincus has invested more than $117 billion in over 1,000 companies globally across its private equity Warburg Pincus' Capital Solutions team collaborates closely with the firm's 270+ investment professionals and 40+ value creation executives across Warburg Pincus' global industry verticals critical to sourcing and underwriting differentiated In addition to a long and successful track record of investing in capital solutions like transactions historically the Warburg Pincus Capital Solutions Founders Fund portfolio consists of investments including Disclaimer and Cautionary Note Regarding Forward-Looking Statements The press release shall not constitute an offer to sell or a solicitation of an offer to purchase any securities of Miami International Holdings solicitation or sale in any state or jurisdiction in which such offer; solicitation or sale would be unlawful This press release may contain forward-looking statements including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 Forward-looking statements describe future expectations or strategies and are generally preceded by words such as "may," "future," "plan" or "planned," "will" or "should," "expected," "anticipates," "draft," "eventually" or "projected." You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances or results to differ materially from those projected in the forward-looking statements including the risks that actual results may differ materially from those projected in the forward-looking statements All third-party trademarks (including logos and icons) referenced by the Company remain the property of their respective owners the Company's use of third-party trademarks does not indicate any relationship or endorsement between the owners of these trademarks and the Company Any references by the Company to third-party trademarks is to identify the corresponding third-party goods and/or services and shall be considered nominative fair use under the trademark law Media Contacts: Andy Nybo, SVP, Chief Communications Officer (609) 955-2091 [email protected] Sarah Bloom, Warburg Pincus [email protected] a technology-driven leader in building and operating regulated financial markets across multiple asset.. Computer & Electronics Financing Agreements the London-based specialist insurance intermediary announced that its acquisition by Warburg Pincus With the necessary regulatory approvals now received the partnership marks a pivotal moment in its journey as it embarks on the next phase of its growth strategy that will help to internationalize its business The deal values SRG at more than £1 billion ($1.3 billion) including debt, according to news reports in May when the deal was first announced The partnership with Warburg Pincus and Temasek underscores the strength of SRG’s business model and the confidence of these leading global investors in SRG’s vision and potential The additional firepower from this investment will enable SRG to accelerate its growth and continue to deliver exceptional value to its clients across complex risk sectors “Securing Warburg Pincus and Temasek as our investment partners is not just an endorsement of our business model but a significant milestone that will shape the future of Specialist Risk Group,” commented Warren Downey “This partnership brings greater firepower and a strategic edge enabling us to move decisively through the next chapter of our growth journey,” Downey added “Our vision is to continue our people and culture obsession and specialist orientation whilst expanding internationally With the support of Warburg Pincus and Temasek we are uniquely positioned for the next chapter of the SRG story.” “We are delighted to partner with the talented management team at Specialist Risk Group SRG’s distinctive focus on specialist and complex insurance and its unique people and culture approach sets it apart,” according to James O’Gara “We believe our investment alongside Temasek will help to cement SRG’s leading position in the UK and creates a platform to expand internationally.” Please tell us what we can do to improve this article