water-filled plant could be the key to solving all your hair woes Emily Peterson is an experienced fact-checker and editor with Bachelor's degrees in English Literature and French Sánchez M, González-Burgos E, Iglesias I, et al. Pharmacological ppdate properties of aloe aera and its major active constituents Hekmatpou D, Mehrabi F, Rahzani K, et al. The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review Saddiq AA, Al-Ghamdi H. Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains Rodrigues D, Viotto AC, Checchia R, et al. Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage Metrics details renowned for its medicinal and food applications and cost-effective scaffold material for cultured meat production Our method repurposes Aloe vera parenchyma into a sustainable and innovative scaffold for CM production feature a porous structure that retains liquids and supports bovine mesenchymal stem cell (bMSC) adhesion the scaffolds enable the accumulation of fat-like tissue creating “lipid chunks” that can enhance the texture and flavor profile of plant-based meat alternatives scalability is addressed by culturing the scaffolds in a macrofluidic single-use bioreactor (MSUB) showcasing the potential for large-scale production This work demonstrates Aloe vera scaffold’s versatility as a cost-effective material and highlights its promise for sustainable protein solutions and tissue engineering applications scaffold design must carefully optimize tissue formation without compromising structural integrity The use of edible byproducts in CM is also intensely examined aligning with sustainable practices and leveraging renewable our study addresses the need for cost-effective and scalable bioprocessing solutions by incorporating scaffolds and bioreactors aiming to advance biotechnology applications for tissue engineering and CM production and also opens intriguing culinary possibilities for improving the taste and texture of other alternative protein products a Fresh Aloe vera parenchyma exhibiting honeycomb-like structure b Fresh Aloe vera parenchyma stained with Calcoflour white c Water absorbance assay for freeze-dried Aloe vera scaffolds (n = 3) g Aloe vera gel toxicity assay using NIH/3T3 fibroblasts 0.2–66% Aloe vera gel (n = 3) (scale bar: 500 μm) a Illustration of seeding methods for scaffolds drop-wise vs static adherent seeding b Proliferation assay for 50K NIH/3T3 fibroblasts seeded on Aloe vera scaffolds with gelatin in different concentrations 1:10–1:100 and without gelatin (n = 3) c Proliferation assay for immortalized bovine MSCs seeded on Aloe vera scaffolds in different drop-wise cell seeding concentrations and with 2D adherent seeding (n = 3) d Macroscopic image of scaffolds post cultivation without or (e) with immortalized bMSCs f Coverage plot of immortalized bovine MSCs g Proliferation assay for primary bovine umbilical cord-derived MSCs seeded on Aloe vera scaffolds in different cell seeding concentrations (n = 3) h Confocal microscopy of scaffold without cells and i GFP expressing bMSCs (green) on the scaffold (cyan) (scale bar: 500 μm or 100 μm) a Top-view SEM images of Aloe vera scaffolds without cells (scale bar from left to right: 100 μm b Top-view SEM images of bMSCs growing for 12 days on Aloe vera scaffolds (scale bar from left to right: 100 μm Maturation of the scaffolds post-proliferation was conducted in the MSUB and wells and confocal imaging was used to assess the cells’ viability and growth and lipid droplet accumulation in the oleic acid-induced culture a Representative images of cells after 14 days in standard media culture or in b standard media + 300 μm oleic acid for 2 days Images are maxed projections of 5 μm confocal stacks Data represent two independent experiments: blue: nuclei we describe the resourcing of Aloe vera parenchyma a byproduct from the cosmetics and beverage industries as a scaffold for cultivating bovine stem cells to produce lipid chunks These properties of Aloe vera make it suitable for an industrial food process while enjoying preliminary customer acceptance our observation that gelatine did not enhance the scaffolds suggests that the Aloe vera parenchyma scaffold may possess intrinsic properties conducive to CM production potentially reducing scaffold fabrication costs in industrial settings Fat tissue primarily comprises adipocytes containing lipid droplets which are crucial in determining meat quality and influencing attributes like juiciness These lipid droplets contain neutral lipids which can be broken down into fatty acids by lingual lipase in the mouth The formation of lipid droplets within the scaffold impacts cultivated meat’s nutritional composition and taste fatty acids contribute to meat flavors by generating volatile compounds through oxidation While we have shown lipid accumulation in bMSC grown on AVPC scaffolds we must assess the transcriptional shifts accompanying adipocyte differentiation and explore other tissue differentiation protocols the observations regarding adipogenic buildup require further substantiation in forthcoming studies utilizing primary bMSCs where the first step is to expand the cells in suspension and later to seed them on scaffolds and cultivate them in perfusion This paves the way for an alternative perfusion bioreactor design that facilitates automatic media replacement through perfusion with the right kind of agitation and liquid handling the whole process of expansion and maturation can be done in one MSUB Further optimization of cell distribution could involve reducing scaffold diameter or employing advanced agitation techniques such as packed beds or mechanical-stimuli bioreactors These strategies may improve nutrient and oxygen diffusion and support uniform cell growth within the scaffold our study suggests that Aloe vera scaffolds support mammalian cell proliferation and tissue formation a byproduct of the existing Aloe vera gel production industry presents a simple and sustainable solution for the CM industry The bioprocess using AVPC scaffolds holds promise for producing bovine fat-like chunks which can be used as additives in plant-based meat alternatives or as a step toward creating ’whole cut’ CM products When integrated into macrofluidic single-use bioreactors these Aloe vera scaffolds not only support mammalian cell proliferation and tissue formation but also reinforce sustainability goals by reducing capital expenses associated with traditional tissue culture infrastructure and potentially facilitating scalability in a scale-out model meeting the dynamic demands of the CM industry this paper emphasizes the potential of AVPC scaffolds to overcome current challenges in CM production and pave the way for innovative solutions in the alternative protein sector Aloe vera leaves were brought into the lab and the parenchyma tissue was separated from the rind with a knife The tissue was autoclaved for 30 min at 121 °C in a glass jar (Step 2) and the remaining parenchymal cellulose was placed in a sterile Petri dish Lyophilized tissue was sterilized under UV light for 30 min (Step 5) scaffolds were created (Step 6) and stored in non-treated multi-well plates with a coating solution to prevent cell adhesion (Step 7) Controlled water additions of 10 μl and subsequent wet weight measurements allowed for the calculation of water absorption Wet weight measurements following each addition facilitated the calculation of percent water absorption using the formula [(wet weight − dry weight)/dry weight] × 100] which yields insights into the hygroscopic properties of the scaffolds Scaffolds were measured for pH in the presence of 2 ml water or Dulbecco’s Modified Eagle Medium (DMEM) with a pH meter (Eutech pH 700 Autoclaved Aloe vera gel was added to low glucose DMEM basal medium with 10% FBS and 1% l-glutamine in different concentrations (0.2–66%) Each well was seeded with 55,000 NIH/3T3 cells on a 24-multiwell tissue culture plate (for each concentration n = 3) The cells were then incubated with the gel for two days and the percentage of live cells was determined by trypan blue staining using a cell counter (TC20 automated cell counter The cells were grown in low-glucose Dulbecco modified eagle medium (Gibco USA) containing 10% fetal bovine serum (Gibco) and a penicillin-streptomycin mixture (1%) and cryopreserved in fetal bovine serum containing 10% DMSO GFP-expressing cells were made using pLKO_047 (Broad Institute) lentiviral vector and Puromycin selection all cells were plated in a low-glucose Dulbecco-modified eagle medium (Gibco United States) containing 10% fetal bovine serum (Gibco) 1% l-glutamine and a penicillin-streptomycin mixture (1%) 1mM of bovine FGF2 was supplemented to the media To assess metabolic activity in live culture which operates by converting resazurin to resorufin undergoes reduction reactions in metabolically active cells resulting in the formation of highly red fluorescent resorufin Cells were seeded in wells at 10,000 (10K) to 500,000 (500K) cells per scaffold Static adherent seeding was done by placing the scaffolds on a confluent plate for two days the scaffolds were placed in a non-treated Biofloat©coated 12 or 24-well plate and incubated for 45 min at 37 °C 2 ml of growth medium was added to each scaffold The scaffolds were carefully transferred to a new plate using sterile tweezers The cells were maintained in 2 ml of low glucose DMEM basal medium with 10%FBS Cultivation was done in an incubator at 37 °C and 5% CO2 wells were incubated for 4 h with 2 ml of a solution comprising a 10:1 ratio of growth medium to Alamar Blue reagent stock solution A hundred microliter of the medium was transferred to a clear 96-well plate and fluorescence readings were taken using a plate reader (BioTek Synergy HT Multi-Mode Microplate Reader; Agilent Technologies and the fluorescence was measured at 590 nm following excitation at 520 nm the medium in each well was replaced with 2 ml of fresh medium and 4 ml in the MSUB and flasks we seeded 5000 and 50,000 cells on 2D culture plates without scaffolds 24 h before plate reader analysis The negative control consisted of the growth medium and the blank was a scaffold without cells Cells were seeded drop-wise in 24 μl or by adherent seeding where we placed the scaffolds on a 10 cm tissue culture plate with 2.7 million adherent cells We left the scaffolds on the plate for two days we transferred the scaffolds to a Biofloat©-coated multiwell plate six scaffolds with an Alamar reading of 8–10 were moved to two MSUBs (three scaffolds in each) with 6 ml media for 48-h maturation 300 mM oleic acid was added to one MSUB while the other kept the proliferation media The air pump was placed in the incubator and programmed to provide intermittent CO2-enriched air from the incubator passed through the filter into the MSUB as the tube was aerating close to the bottom of the culture chamber leading to agitation akin to an airlift bioreactor The following methods were employed to prepare histological sections of Aloe vera scaffolds for analysis Aloe vera scaffolds were fixed using a 4% paraformaldehyde (PFA) solution for 24 h the samples were dehydrated through a graded series of ethanol (70% and 100%) for 1 h each and cleared using xylene for 1 h the dehydrated and cleared samples were followed by embedding in paraffin wax blocks and then sectioned into thin slices (5–20 μm thick) using a microtome USA) for cells and extracellular matrix staining according to the standard staining procedure the slides were deparaffinized in HistoChoice®Clearining Agent rehydrated through a graded series of ethanol and mounted with a coverslip using a mounting medium the histological sections were observed under a light microscope and imaged using EVOS M7000 (Invitrogen) Scaffolds were stained at room temperature using Calcofluor white (3 μl/ml and washed with PBS) Scaffolds were stained with 1 μg/ml−1 Hoechst (Thermo Fisher 62249) for nuclei and 0.1% v/v Nile red (Thermo Fisher Fluorescence imaging was performed either using an Inverted Nikon ECLIPSE TI-DH fluorescent microscope or by Confocal imaging using a Leica SP8 Confocal Microscope or imaged live with a BC43 Benchtop Confocal Microscope (Oxford Instruments) SEM images were acquired by a JSM-7800F field emission scanning electron microscope; the scaffolds were dried with a K850 critical point dryer and coated with a Q150T ES Plus at 18mA for 90 sec with 2 nm AuPd Statistical analysis was performed using GraphPad Prism version 9.00 (GraphPad Software) The figure legends detail specific statistical tests The data that support the findings of this study are available from the corresponding author upon reasonable request. Additional materials have been provided as part of the submission process or included in the manuscript as Supplementary Information Aloe vera gel and whole leaf extract: functional and versatile excipients for drug delivery biological activities and pharmacological applications of acemannan Compositional and structural features of the main bioactive polysaccharides present in the aloe vera plant A review on the relationship between aloe vera components and their biologic effects food applications and safety of aloe vera products: a review Design and feasibility test of in-house indirect perfusion bioreactor for 3-d cell culture In 2023 15th Biomedical Engineering International Conference (BMEiCON) Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering Apple derived cellulose scaffolds for 3d mammalian cell culture Cellulose-based scaffold materials for cartilage tissue engineering Cellulose-based materials as scaffolds for tissue engineering Decellularised baby spinach leaves and their potential use in tissue engineering applications: Studying and promoting neovascularisation The latest achievements in plant cellulose-based biomaterials for tissue engineering focusing on skin repair Scaffolds for the manufacture of cultured meat A review of the application of cellulose-based biomaterials for cultured meat production Plant tissues as 3d natural scaffolds for adipose Recent advances in development of natural cellulosic non-woven scaffolds for tissue engineering Plant-based scaffolds in tissue engineering The emerging role of decellularized plant-based scaffolds as a new biomaterial Engineering aligned skeletal muscle tissue using decellularized plant-derived scaffolds Preparation and properties of bamboo fiber/nano-hydroxyapatite/poly (lactic-co-glycolic) composite scaffold for bone tissue engineering Integrating biomaterials and food biopolymers for cultured meat production Immunobiology and application of aloe vera-based scaffolds in tissue engineering A review of mechanical properties of scaffold in tissue engineering: Aloe vera composites Preparation and characterization of aloe vera blended collagen-chitosan composite scaffold for tissue engineering applications Development of biodegradable electrospun gelatin/aloe-vera/poly (ε-caprolactone) hybrid nanofibrous scaffold for application as skin substitutes Polymer-based scaffolds loaded with aloe vera extract for the treatment of wounds Aloe vera-derived gel-blended phbv nanofibrous scaffold for bone tissue engineering Evaluation of aloe vera coated polylactic acid scaffolds for bone tissue engineering Evaluation of collagen type i scaffolds including gelatin-collagen microparticles and aloe vera in a model of full-thickness skin wound Nature-derived aloe vera gel blended silk fibroin film scaffolds for cornea endothelial cell regeneration and transplantation Industrial processing and quality control of aloe barbadensis (aloe vera) gel 492–506 (Open Access Science Research Publisher Isolation and characterization of structural components of aloe vera l Compositional features of polysaccharides from aloe vera (aloe barbadensis miller) plant tissues Group, I. Aloe Vera Gel Manufacturing Plant Project Report 2024: Industry Trends, Plant Setup, Manufacturing Process, and Business Plan (IMARC, accessed 18 November 2024); https://www.imarcgroup.com/aloe-vera-gel-manufacturing-plant F&B, I. Aloe Vera Production (Interfresh, accessed 18 November 2024); https://interfresh.com.vn/aloe-vera-production/ Development of an aloe vera-based functional drink Formulation and senso-chemical evaluation of aloe vera (aloe barbadensis miller) based value added beverages Effect of storage time on aloe vera beverage microbial and sensory analysis of aloe vera (pulp) ice cream with natural colour in different artificial sweeteners Gome, G. et al. Cultivation of bovine mesenchymal stem cells on plant-based scaffolds in a macrofluidic single-use bioreactor for cultured meat. Foods. https://doi.org/10.3390/foods13091361 (2024) sustainability and regulatory challenges of cultured meat Cultured meat and the sustainable development goals Critical review of cultivated meat from a nordic perspective Cultured meat production fuelled by fermentation Aloe vera: from ancient knowledge to the patent and innovation landscape—a review Large-scale cultured meat production: trends challenges and promising biomanufacturing technologies Engineered marble-like bovine fat tissue for cultured meat My first biolab: a system for hands-on biology experiments In Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems Adult mesenchymal stem cells: characterization Applications of mesenchymal stem cell technology in bovine species Heat shock alters mesenchymal stem cell identity and induces premature senescence Addgene. Human Telomerase Gene hTERT (accessed 11 February 2024); https://www.addgene.org/1773/ Download references Laser welding of macrofluidics is supported by and sprouted at the media innovation lab (milab) at Reichman University led by prof Oren Zuckerman Guy Aidelberg from CRI Paris for fruitful discussions and Prof We thank GFI-Israel for their goodwill and support and the members of the CM consortium for fruitful discussions we wish to thank all the members of the Schlesinger Lab for their patience This research was funded by the Israeli Ministry of Innovation and partially supported by the Israeli Innovation Authority through the cultivated meat consortium (file number 82446) Ivana Ribarski-Chorev & Sharon Schlesinger Cell line preparation and quantification: S.T All authors have read and agreed to the published version of the manuscript Further inquiries can be directed to the corresponding authors Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41538-025-00391-1 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology but benefits for UC aren’t backed by research you may have come across aloe vera as a potential remedy the oft-touted benefits aren’t backed by much science certain forms of aloe vera may do more harm than good for people with UC To date, there’s just one human study looking at whether aloe vera can help with ulcerative colitis. A small randomized controlled trial of 44 patients with mild to moderate UC, published in Alimentary Pharmacology & Therapeutics found that subjects who took 100 mL of aloe vera gel orally in addition to their usual treatment regimen experienced a bigger symptom improvement compared to those who took a placebo with 30% of people in the treatment group achieving clinical remission compared to just 7% in the placebo group Aloe vera is known to have a wide range of anti-inflammatory compounds, per the National Library of Medicine. That could potentially explain the study’s findings, says Wendi LeBrett, M.D. a gastroenterologist with the Digestive Health Clinic in Boise it’s not enough to convince her—or other experts—that aloe vera is a worthy option for managing ulcerative colitis “I just don’t think there’s enough evidence to support that,” she adds Pornchai Leelasinjaroen, M.D. a board-certified gastroenterologist with Gastro Health in Kennewick “Given the limited data from a single small study aloe vera gel is considered a weak signal of potential benefit in milder cases It is not FDA-approved for ulcerative colitis,” he says it’s possible that taking aloe vera gel (not aloe vera juice—we’ll get into the difference below) could indirectly help you manage your symptoms “If a patient strongly believes in its benefits this belief might provide psychological comfort and stress relief which can positively impact disease activity as stress is known to exacerbate inflammatory bowel disease,” Dr you can think of it as possibly having a helpful placebo effect Your Email...requiredPlease Enter a Valid Email AddressYour privacy is important to us.Aloe Vera Gel vs Aloe Vera JuiceWhen you look up aloe vera supplements you’ll come across aloe vera gel and aloe vera juice Aloe vera gel is extracted from the thick, fleshy inner pulp of the aloe vera leaf. It’s most often used topically for skin issues like sunburns, per the Mayo Clinic But it can also be taken in capsule form (like in the UC study) Not exactly what people with UC want or need If you’re thinking about taking aloe vera for your UC it’s important to know the potential downsides like worsening symptoms and severe complications,” she adds Aloe vera juice is a stimulant laxative that’s used to treat constipation Since diarrhea and urgency are common UC symptoms it’s likely that taking aloe vera juice could make those problems worse instead of better it could be harder to figure out whether the culprit is the aloe vera juice or your UC getting worse Aloe vera gel generally isn’t known to have a laxative effect, per the Mayo Clinic. But it could potentially cause diarrhea or abdominal cramping if you’re allergic to it. (People who are allergic to aloe vera many also be allergic to related plants like onions and tulips, according to a paper published in the Journal of Environmental Science and Health.) High doses of aloe vera (for example, one gram a day for several days) may lead to kidney damage, and over time, it could have a carcinogenic effect, the Mayo Clinic notes. It’s also tied to cases of acute liver inflammation, per the National Center for Complementary and Integrative Health (NCCIH) Drinking aloe vera juice can temporarily cause melanosis coli, a pigmentation condition where the lining of the colon turns black, per research published in the journal Internal Medicine The color change isn’t actually harmful and doesn’t cause any symptoms But if you’re experiencing melanosis coli when you have a colonoscopy the darker pigmentation “may make it harder for your gastroenterologist to see any potential inflammation in your colon,” she adds Aloe vera isn’t a recommended treatment for ulcerative colitis so there are no established guidelines for how to take it aloe vera gel capsules are a better choice than aloe vera juice Be sure to talk with your doctor first. Together you can weigh the pros and cons, discuss dosing, and decide whether it’s safe to incorporate the aloe vera into your treatment plan “Aloe vera gel could be considered as a supplement alongside standard treatment,” says Dr but you shouldn’t take it in place of your prescribed medication You shouldn’t rely on aloe vera gel by itself to manage your ulcerative colitis regardless of whether your symptoms are under control or flaring potentially increase the risk of complications It’s also best to avoid aloe vera juice altogether Let your doctor know if you’re considering trying aloe vera gel to manage your UC. While it’s not advisable to take the supplement on its own, “taking aloe vera gel as an adjunct to prescribed treatment is an option as long as a patient is fully informed of the pros and cons,” says Dr Aloe Vera UCS: Alimentary Pharmacology & Therapeutics. (2004.) “Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis.” https://pubmed.ncbi.nlm.nih.gov/15043514/ Aloe Vera Gel vs. Aloe Vera Juice: Mayo Clinic. (2023.) “Aloe.” https://www.mayoclinic.org/drugs-supplements-aloe/art-20362267 Aloe Allergy: Journal of Environmental Science and Health. (2016.) “Aloe vera: A review of toxicity and adverse clinical effects.” https://www.tandfonline.com/doi/full/10.1080/10590501.2016.1166826 Aloe Vera Risks: National Center for Complementary and Integrative Health. (2020.) “Aloe Vera.” https://www.nccih.nih.gov/health/aloe-vera Melanosis Coli: Internal Medicine. (2020.) “Melanosis Coli Due to Aloe Vera Consumption.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662051/ In the United States, the Food and Drug Administration (FDA) does not regulate supplements like prescription drugs. This means some supplement products may not contain what the label says. When choosing a supplement look for third-party tested products and consult a healthcare provider registered dietitian nutritionist (RDN or RD) Supplement use should be individualized and vetted by a healthcare professional such as aregistered dietitian nutritionist (RD or RDN) Oral aloe vera latex may improve constipation symptoms Food and Drug Administration (FDA) banned the use of aloe vera latex as an ingredient in nonprescription laxatives due to safety concerns Prolonged use of aloe vera latex has been linked to diarrhea National Center for Complementary and Integrative Health. Aloe vera Salehi B, Albayrak S, Antolak H, et al. Aloe genus plants: from farm to food applications and phytopharmacotherapy Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents Bałan BJ, Niemcewicz M, Kocik J, et al. Oral administration of Aloe vera gel, anti-microbial and anti-inflammatory herbal remedy, stimulates cell-mediated immunity and antibody production in a mouse model Naini MA, Zargari-Samadnejad A, Mehrvarz S, et al. Anti-inflammatory, antioxidant, and healing-promoting effects of Aloe vera extract in the experimental colitis in rats Hęś M, Dziedzic K, Górecka D, et al. Aloe vera (L.) Webb.: natural sources of antioxidants – a review PubChem. Salicylic acid U.S. Department of Health & Human Services Office on Women's Health. Inflammatory bowel disease Hassanshahi N, Masoumi SJ, Mehrabani D, et al. The healing effect of aloe vera gel on acetic acid-induced ulcerative colitis in rat Bahrami G, Malekshahi H, Miraghaee S, et al. Protective and therapeutic effects of aloe vera gel on ulcerative colitis induced by acetic acid in rats Hekmat-Ardakani A, Morshed-Behbahani B, Rahimi-Ardabili H, et al. The effects of dietary supplements and natural products targeting glucose levels: an overview Suksomboon N, Poolsup N, Punthanitisarn S. Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis Zhang Y, Liu W, Liu D, et al. Efficacy of aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials Shakib Z, Shahraki N, Razavi BM, Hosseinzadeh H. Aloe vera as an herbal medicine in the treatment of metabolic syndrome: a review Fu S, Dang Y, Xu H, et al. Aloe vera-fermented beverage ameliorates obesity and gut dysbiosis in high-fat-diet mice Walid R, Hafida M, Abdelhamid EHI, et al. Beneficial effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese rats Panahi Y, Khedmat H, Valizadegan G, et al. Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review Wang T, Liao J, Zheng L, et al. Aloe vera for prevention of radiation-induced dermatitis: a systematic review and cumulative analysis of randomized controlled trials Elkhawaga OY, Ellety MM, Mofty SO, et al. Review of natural compounds for potential psoriasis treatment Nasri H, Bahmani M, Shahinfard N, et al. Medicinal plants for the treatment of acne vulgaris: a review of recent evidences Sharma S, Alfonso AR, Gordon AJ, et al. Second-degree burns and aloe vera: a meta-analysis and systematic review Huang YN, Chen KC, Wang JH, Lin YK. Effects of Aloe vera on burn injuries: a systematic review and meta-analysis of randomized controlled trials Zou H, Liu Z, Wang Z, Fang J. Effects of aloe vera in the treatment of oral ulcers: a systematic review and meta-analysis of randomised controlled trials Sahebjamee M, Mansourian A, Hajimirzamohammad M, et al. Comparative efficacy of aloe Vera and benzydamine mouthwashes on radiation-induced oral mucositis: A triple-blind, randomised, controlled clinical trial [published correction appears in Oral Health Prev Dent Haji Mirza Mohammad [corrected to Hajimizamohammad National Institutes of Health Office of Dietary Supplements. Dietary supplement label database: aloe vera Guo X, Mei N. Aloe vera: a review of toxicity and adverse clinical effects J Environ Sci Health C Environ Carcinog Ecotoxicol Rev Ge B, Zhang Z, Zuo Z. Updates on the clinical evidenced herb-warfarin interactions Gupta RC, Chang D, Nammi S, et al. Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications U.S. Food and Drug Administration. Status of certain additional over-the-counter drug category II and III active ingredients. Final rule. Fed Regist. 2002;67(90):31125-31127. Thank you, {{form.email}}, for signing up. we may receive compensation from retailers and/or from purchases of products through these links If a plant could be called “iconic,” aloe vera would warrant the description everyone wants an aloe vera plant on their window as well as in your living room—has been used for centuries for its beautifying and medicinal benefits (there’s a reason it’s in all your most calming skincare products) From its anti-inflammatory effects to antimicrobial properties is that you can reap plenty of benefits by going straight to the source—by drinking pure aloe vera juice which you can buy from most health food shops (don’t go crunching on the aloe vera plant in your bedroom the latex surrounding the gel inside the leaves can irritate the stomach) When I first started incorporating aloe into my morning breakfast routine Here’s everything you need to know about aloe vera juice and its many benefits Depending on the type of juice you go for (there are sugary options that don’t contain the same health benefits or the 100% pure and organic kind) aloe vera can taste a little bitter and mildly citrusy I like stirring a 50ml shot of the pure stuff into a glass of coconut water in the morning with ice or throwing it into a smoothie where it’s barely noticeable But a lot of people find it easier to just knock back a few neat tablespoons and it’s been used for everything from oral health and blood sugar control to digestive support and skin quality.” For the specifics We know that aloe vera gel can be used topically to treat a variety of ailments (you’ve probably used it at least once to soothe sunburn). Some studies have shown that consuming it can be great for the skin “Drinking aloe vera juice can help improve skin elasticity and reduce signs of aging,” says Morgan “It can also help with acne or other skin conditions as it has anti-inflammatory and antimicrobial properties.” aloe vera juice is rich in antioxidants and vitamins all of which can help aid and regulate a person’s immune system “Aloe vera contains vitamins C and E and beta-carotene all of which are antioxidants that can help fight oxidative stress and strengthen the immune system,” says Morgan “It also has anti-inflammatory properties that can help modulate the immune response.” “Aloe vera juice is known to have a soothing effect on the digestive tract due to its mucilaginous properties and polysaccharide content,” says Morgan adding that it can also “help reduce symptoms of acid reflux It’s unusual for a drink that isn’t water to actually help with oral hygiene rather than hinder it, but such is the magic of this humble household plant. Some preliminary studies have even shown that aloe can be used as mouthwash “Aloe vera has antimicrobial properties that may help with oral health by reducing plaque adding that the juice “can help soothe and heal mouth ulcers and sores” In general, says April, the recommended dose is between 50 and 120 ml of aloe vera juice per day —so you don’t need to be glugging the stuff like water. If you’re using it to aid with digestive health, it can be helpful to drink before a meal. Otherwise, you’re good to have your daily aloe whenever. 4 Signs You’re Not Getting Enough Protein This Tiny Fruit Has More Vitamin C Than Oranges and Tons of “Beauty Omegas” At What Age Do We Feel The Most Happiness? The Answer May Surprise You I Traded My Coffee For Green Tea—And My Energy Levels Transformed Sign up for Vogue’s beauty and wellness newsletter to receive the insider’s guide to all things beauty and wellness Never miss a Vogue moment and get unlimited digital access for just $2 $1 per month Grow new plants from your existing ones by learning how to propagate aloe Luo X, Zhang H, Wei X, et al. Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of nf-κb. Molecules. 2018;23(3):517 8 best aloe vera gels, tested by editors and dermatologists assistant professor of dermatology at the School of Medicine said she recommends aloe vera gels with as high of a concentration of aloe as possible—at least 15-20%—to treat sunburn noting that some of the purest formulas have as much as 100% aloe vera Interested in participating in a research study Looking for an upcoming event in your department Subscribe to The Daily Items that appear in the Community Postings section are submitted by visitors. Posts are reviewed to ensure they are appropriate for our audience, but typically are not edited by University Marketing and Communications. Case Western Reserve University is committed to academic freedom and promoting diversity of thought. The views of those who speak on our campus do not necessarily reflect the views of the university administration or any other segment of the university community. News & Analysis on Food & Beverage Development & Technology 13-Nov-2024 Last updated on 25-Nov-2024 at 24:59 GMT A European Commission ban on the use of aloe vera preparations used in food has been annulled by the EU General Court following a lengthy legal battle. A ban was enforced in March 2021, with legal firms pursuing an overturn from May in the same year. The ban covered botanical species containing hydroxyanthracene derivatives (HADs), which included aloe extracts, a decision that had a huge impact on the nutrition and nutricosmetic industries. The European commission had “overstepped the mark” in prohibiting preparations instead of individual substances, critics from the food sector blasted. Moreover, the ban was based on an EFSA scientific assessment, from which the EU General Court failed to identify evidence of consumer risk. A case lodged in May by legal firm Covington & Burling set a precedent and resulted in the overturn. “The Commission has no power to ban botanical ‘preparations’ under this regulation and the court agreed that the Commission had overstepped the mark,” said Covington & Burling partners Brian Kelly and Bart Van Vooren. “As the court said, there was nothing in the EFSA 2017 scientific opinion on or from any material in the case file that indicated the substances and preparations in question actually represented a potential risk to consumers. “The case will have wider significance for how the Commission undertakes the risk management decisions and EFSA’s hazard versus risk approach to risk assessments.” The original ruling, based on the 2017 scientific opinion, stated: “Considering the severe harmful effects on health associated with the use of aloe-emodin, emodin, danthron and aloe extracts containing hydroxyanthracene derivatives in food, and that no daily intake of hydroxyanthracene derivatives that does not give rise to concerns for human health could be set, such substances should be prohibited.” It concluded aloe-emodin, emodin, danthron and aloe preparations containing hydroxyanthracene derivatives should be included in Annex III, Part A of Regulation (EC) No 1925/2006. Are children’s foods lacking vital nutrients?02-Sep-2024By Donna EastlakeChildhood nutrition is in a state. But is this down to badly-manufactured children's foods or a symptom of a bigger problem? And will parents place the blame with food manufacturers regardless? Revealed: New food tech and ingredients innovations02-Sep-2024By Nicholas RobinsonThe food and drinks brands delivering head-turning sustainable tech and novel ingredients innovations are uncovering their secrets and industry insight at an exclusive, free-to-attend digital event. $40bn personalised nutrition market tapped for growth with Xampla and Lehmann tie-up 28-Aug-2024By Nicholas RobinsonPlastic replacement technology firm Xampla’s partnership with Lehmann Ingredients will seek to build on global consumers’ growing demand for personalised nutrition. Recent success for Welsh food and drink as it targets international marketsPaid for and content provided by Welsh Government Mastering mouthfeel: The importance of mouthfeel in making brands thrivePaid for and in partnership with Tate & Lyle Rethinking eggs for a resilient food future a ‘matter of necessity’Paid for and content provided by CSM Group (CSM Ingredients & HIFOOD) About us | Advertise with us | Contact us Posted: 12 March 2025 | | No comments yet Researchers repurpose Aloe vera to improve taste offering a sustainable and cost-effective solution A new study, published in npj Science of Food has revealed an innovative use for Aloe vera in cultured meat production showing how this widely available plant can enhance taste By repurposing Aloe vera as a natural scaffold researchers have created fat-like structures that could make lab-grown meat more commercially viable and appealing to consumers its use in cultured meat could provide a sustainable alternative to synthetic scaffolds The study also introduces a pioneering bioprocessing approach, incorporating Aloe vera scaffolds into a macrofluidic single-use bioreactor (MSUB). Developed at Reichman University by Dr. Jonathan Giron and his team, this technology enables large-scale making cultured meat more commercially feasible Aloe vera’s high liquid absorption capacity creates an ideal environment for cell growth without requiring additional structural support and Environment at the Hebrew University of Jerusalem Aloe vera has long been known for its medicinal and nutritional benefits but our study shows it also holds great potential for sustainable food production By repurposing this natural byproduct into a biocompatible scaffold we are taking a significant step toward scalable cost-effective cultured meat production that could help address global food security and environmental challenges.” This research comes at a pivotal time, as policymakers look to accelerate the process and get these products onto the market. In the UK, the Food Standards Agency (FSA) recently launched a regulatory sandbox to explore ways to streamline the approval process for cultivated meat The FSA has committed to conducting full safety assessments on two Cultivated Cell Products (CCPs) within the next two years the industry is closely monitoring how developments such as Aloe vera scaffolds may shape the commercial future of lab-grown meat Aloe vera’s FDA-approved status as a food additive strengthens its potential for commercial adoption in cultivated meat this breakthrough could accelerate the shift toward more efficient and environmentally friendly protein production By No comments yet All subscriptions include online membership giving you access to the journal and exclusive content By By Comment * document.getElementById("comment").setAttribute( "id" "a012a477e2032494bd086e07d6f56540" );document.getElementById("de5d8d4fb7").setAttribute( "id" Write for us | Advertise with us New Food is published by: Russell Publishing Ltd.Court LodgeHogtrough HillBrasted © Russell Publishing Limited, 2010-2025. All rights reserved. Terms & Conditions | Privacy Policy | Cookie Policy Website design and development by e-Motive Media Limited Necessary cookies are absolutely essential for the website to function properly This category only includes cookies that ensures basic functionalities and security features of the website These cookies do not store any personal information CookieDescriptioncookielawinfo-checkbox-advertising-targetingThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".cookielawinfo-checkbox-analyticsThis cookie is set by GDPR Cookie Consent WordPress Plugin The cookie is used to remember the user consent for the cookies under the category "Analytics".cookielawinfo-checkbox-necessaryThis cookie is set by GDPR Cookie Consent plugin The cookie is used to store the user consent for the cookies in the category "Necessary".cookielawinfo-checkbox-performanceThis cookie is set by GDPR Cookie Consent WordPress Plugin The cookie is used to remember the user consent for the cookies under the category "Performance".PHPSESSIDThis cookie is native to PHP applications The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website The cookie is a session cookies and is deleted when all the browser windows are closed.viewed_cookie_policyThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies It does not store any personal data.zmember_loggedThis session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users Metrics details Phage therapy offers a promising alternative to antibiotic treatment for combating illnesses caused by multidrug-resistant bacteria pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa were isolated from pus and skin infected fluidsusing selective media These bacterial isolates were biochemically identified as S aeruginosa with probabilities of 98% and 99% and were confirmed as multidrug-resistant based on minimum inhibitory concentration test using colorimetric reagent cards Lytic phages specific to these isolates were isolated transmission electron microscopy and classified morphologically according to the new International Committee on Taxonomy of Viruses classification as members of the Straboviridae A cosmetic gel formulation combining Aloe vera extract and the phage cocktail was prepared and tested This gel significantly enhanced phage longevity and reduced bacterial growth by 95.5% compared to the reductions of 90.5% with Aloe Vera extract alone and 45.7% with the basic cosmetic gel The phage remained effective for 4 to over 12 weeks after being preserved in the cosmetic formula maintaining populations ranging from 5 × 103 to 25 × 104 PFU/mL in vitro These findings highlight the potential of phage-based formulations as innovative biotherapeutic tools for managing skin infections As the effectiveness of traditional antibiotics diminishes alternative treatments are urgently needed to address these challenges The combination of phage therapy and Aloe vera extract offers a synergistic approach to combating multidrug-resistant bacterial infections Phages specifically target and lyse pathogenic bacteria while Aloe vera enhances this effect through its broad-spectrum antimicrobial properties and ability to promote wound healing This combined approach can potentially overcome the limitations of antibiotic therapy and provide a more effective treatment for stubborn skin infections caused by S Bacteriophage therapy and Aloe vera extract represent promising alternative treatments that can enhance antibacterial activity and improve clinical outcomes Their combined use could lead to more effective management of skin infections particularly those caused by multidrug-resistant pathogens 50 g of leaves were macerated in a warning blender for 10 min with 100 mL of sterile distilled water The macerate was then filtered through two layers of muslin cloth and centrifuged at 4000×g for 30 min The supernatant liquid was heat sterilized and further filtered using Wattman No.1 filter paper the extract was stored aseptically at 5 °C Clinical swabs were collected from patients with edema and vesicles that produced pus and fluid at the dermatology hospital in Qalyubia governorate These swabs were placed in nutrient broth tubes and incubated at 37 °C until used This procedure was conducted in accordance with relevant institutional and international guidelines and legislation as approved by the Research Ethics Committee at Ain Shams University The nutrient broth containing clinical swabs was diluted in broth medium and inoculated onto cetrimide agar (Oxoid; CM559) for P aeruginosa and Baird Parker media (Oxoid; CM0275) for S The inoculated plates were incubated at 37 °C for 48 h The isolated cultures were identified using Gram staining and the minimal inhibitory concentration (MIC) of selected antibiotics was determined using colorimetric reagent cards from BioMérieux These cards were incubated and automatically read by the VITEK2 system aeruginosa bacterial lawns were cultured on nutrient agar plates by adding 200 µL of tested bacteria (OD of 0.4 at 600 nm) to 4 mL semi-solid nutrient agar and pouring the mixture over nutrient agar plates 10 µL of bacteriophage sources were then deposited on bacterial lawns and allowed to dry Plates were incubated overnight at 37 °C to develop lytic spots Single plaque assay was performed using a sterile pasture pipette to isolate bacteriophages28 A single plaque was removed and incubated at 37 °C with shaking at 1200 rpm in 0.5 ml of nutrient broth containing 100 μL of S The mixture was centrifuged at 10,000×g for 10 min The bacteria were removed by filtering the supernatant through a 0.45 μm Millipore membrane The phage combinations were stored at 4 °C in 2 mL Eppendorf tubes Purified phage samples (107 PFU/mL) were negatively stained with 1% aqueous uranyl acetate and examined using a transmission electron microscope (JEOL-JEM-1010 TEM) at the Regional Center for Mycology Flow diagram outlining the experimental process for assessing the antibacterial activity of a cosmetic gel infused with Aloe vera extract and a phage cocktail The Aloe vera extract was prepared and combined with phage lysate then 100 µL of this mixture was applied to microtiter plates on a bacterial lawn Comparisons were made between the formulated gel bacterial growth was measured at 620 nm OD using an ELISA microplate reader expressed as means ± SE from three replicates aeruginosa was dispensed into ELISA plates (200 µL/well in 3 replicates) 50 µL of phage populations (5 × 106 PFU/mL) and formulated cosmetic with phages were added to the wells Positive control wells contained tested bacteria without treatment and negative control wells contained only TSB broth medium plates were washed three times with 2.0 mL phosphate buffer (pH 7.2) and the optical density of cell viability and biofilm samples was measured at 620 nm and 570 nm The study was conducted three times with consistent results The experiments were conducted in three separate tests Antibacterial activity data were statistically evaluated using SPSS for Windows 16.0 Differences among means were tested at a significance level of P < 0.05 Results were considered statistically significant if P < 0.05 b) indicating significant differences (P < 0.05) Pseudomonas aeruginosa colonies exhibited a blue-green pigment called pyocyanin with light outer edges and greenish-black centers Staphylococcus aureus colonies on Baird Parker agar appeared gray-black with a white boundary and a clearing zone around them aeruginosa cells were straight rods and Gram-negative aureus cells were cocci in clusters and Gram-positive aureus were confirmed with excellent probabilities of 98% and 99% after full biochemical identification using the VITEK2 system Both bacterial isolates were found to be multidrug-resistant based on minimum inhibitory concentration (MIC) testing with VITEK2 colorimetric reagent cards Electro-micrograph represents the morphology of nine different bacteria viruses specific to S The nine phage isolates targeting S. aureus and P. aeruginosa exhibited stability across a range of pH values (4, 5, 6, 7, 8, 9, and 10) at 37 °C for 30 min. Phage survival was assessed through double-layer plaque assay technique in vitro, utilizing S. aureus and P. aeruginosa isolates as indicator hosts (Table 3) The effects of cosmetic gel (CG), Aloe vera extract (AVE), phage cocktail (PC), and their combined formulation on cell viability and biofilm formation were assessed (Table 5) Significant reductions in cell viability were observed the formulated cosmetic gel (FCGAVEPC) exhibited strong antibiofilm activity compared to its individual components The ingredients of the formulated CG significantly reduced biofilm formation by 18.93% The formulated phage cocktail showed efficacy against both S. aureus and P. aeruginosa isolates. Its effectiveness persisted when mixed with CG for one month under room and cooling temperature. Moreover, it maintained its effectiveness for two months when mixed with AVE and for three months when mixed with CG + AVE at room and 4 °C temperature (Table 6) This study explores the antibacterial activity of Aloe vera gel extracts against common pathogens responsible for skin infections the extract was tested against Staphylococcus aureus and pseudomonas aeruginosa all of which showed positive results demonstrated that Aloe vera gel extracts exhibited significant inhibitory effects on all tested bacterial strains These findings suggest that Aloe vera possesses potent antibacterial properties making it a promising natural alternative for the treatment of skin infections The presence of chemical preservatives and antimicrobials in the cosmetic and Aloe extract each with distinct mechanisms of action against S who reported that Aloe vera exhibited broad-spectrum antibacterial properties against E This broad-spectrum activity is attributed to compounds like coumaric acid identified using thin-layer chromatography (TLC) and known to work synergistically the antibacterial effects of anthraquinones and saponins were noted Recent studies, such as those by41 have highlighted Aloe vera as a versatile natural cosmetic ingredient Aloe vera is easily accessible and widely cultivated in Indonesia Aloe vera is used in various cosmetic products Aloe vera extract exhibits significant antibacterial properties The antimicrobial effects of Aloe vera extract were particularly pronounced against Gram-positive bacteria like S Antimicrobial and antioxidant preservatives further suppress oxidation processes and prevent free radical formation extending the product’s shelf life and usage time beyond that of the cosmetic product without Aloe extract gel highlight the potential of bacteriophages as low-risk high-efficiency alternatives for treating antibiotic-resistant infections aeruginosa were detected in infected skin using the overlay technique and identified based on plaque morphology and morphotypes or curled non-contractile tails (200.3 to 245.5 nm in length and 15.4 to 18.5 nm in width) and head diameters (65.2 to 75.5 nm) were classified into the families Myoviridae and Siphoviridae based on the old ICTV classification The stability of bacteriophage populations at room temperature was assessed in a host-free environment The combination of bacteriophages with the formulated cosmetic Aloe vera gel significantly increased the longevity of the phages against S aeruginosa for over three months at room temperature These phages also demonstrated stability across a pH range of 4–10 and under UV irradiation up to 45 cm for 30 Phage survival was determined using the plaque assay technique with S Ensuring the stability of bacteriophages during storage is a crucial aspect of their application which should be clearly defined for selected phages the amount of unabsorbed phage was estimated using the double-layer agar technique defined as the time until substantial amounts of phage particles first appeared This indicates that both the phage adsorption time and latent period were brief along with the high production of lytic phages in host bacterial cells aeruginosa cells attach to surfaces and become immobilized in a polysaccharide matrix to form biofilms Due to the protective extracellular polymeric substance (EPS) layer aeruginosa are more resistant to sanitation treatments than their free-floating counterparts The biofilm hinders the penetration of chemicals Scientific studies have investigated the use of phages to inhibit biofilm formation by bacteria such as Pseudomonas spp. This research highlights the potential of combining Aloe vera gel with phage populations to enhance the effectiveness of phage therapies offering a novel approach to treating antibiotic-resistant bacterial infections and improving skin health The efficacy of combining bacteriophages and Aloe vera extract as antibacterial agents demonstrates significant potential in combating pathogenic bacteria particularly those that are multidrug-resistant with their specificity and ability to lyse bacterial cells offer a promising alternative to traditional antibiotics especially in the face of increasing antibiotic resistance enhances this therapeutic approach through its bioactive compounds which inhibit bacterial growth and biofilm formation This synergistic application not only broadens the antimicrobial spectrum but also improves the overall effectiveness of treatment The Aloe vera extract provides a conducive medium for bacteriophage stability and activity ensuring prolonged and effective bacterial eradication the integration of bacteriophages and Aloe vera extract into a single therapeutic regimen offers a novel and potent strategy to address the challenges posed by antibiotic-resistant bacteria This approach not only provides an effective means of bacterial control but also promotes better skin health highlighting its potential as a valuable tool in modern antimicrobial therapy The authors declare that the article contains all the data established and analyzed during this investigation Bacterial biofilms: A common cause of persistent infections Pseudomonas aeruginosa: New insights into pathogenesis and host defenses Antibiotic resistance: One health one world outlook Phage products for fighting antimicrobial resistance Bacteriophages and their lytic enzymes as alternative antibacterial therapies in the age of antibiotic resistance Phage therapy in Poland: A centennial journey to the first ethically approved treatment facility in Europe Phage therapy for antibiotic-resistant bacterial infections Control of antibiotic-resistant Salmonella enterica serovar Typhi in water and milk using phage cocktail The advantages and challenges of using endolysins in a clinical setting Lysins breaking down the walls of gram-negative bacteria Treating bacterial infections with bacteriophage-based enzybiotics: In vitro Phage therapy: A different approach to fight bacterial infections Phage-Antibiotic therapy as a promising strategy to combat multidrug-resistant infections and to enhance antimicrobial efficiency Preventing biofilms of clinically relevant organisms using bacteriophage Bacteriophage therapy for challenging bacterial infections: Achievements limitations and prospects for future clinical use by veterinary dermatologists Pharmacological update properties of Aloe vera and its major active constituents Antimicrobial activity of Aloe barbadensis Miller leaf gel components Phytochemical constituents of Aloe vera and their multifunctional properties: A comprehensive review Composition and applications of Aloe vera leaf gel Improved antibacterial efficacy of bacteriophage-cosmetic formulation for treatment of Staphylococcus aureus in vitro Therapeutic potential of Aloe vera—A miracle gift of nature Antagonistic properties of microogranisms associated with cassava (Manihot esculenta Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating gutta percha cones volume 2: molecular and applied aspects (Vol Novel patterns of ultraviolet mutagenesis and Weigle reactivation in Staphylococcus aureus and phage ϕ11 Use of a mixture of bacteriophages for biological control of Salmonella enterica strains in compost Isolation and characterization of a novel phage SaGU1 that infects Staphylococcus aureus clinical isolates from patients with atopic dermatitis Adherence of coagulase-negative staphylococci to plastic tissue culture plates: A quantitative model for the adherence of staphylococci to medical devices Chronic wound infections: The role of Pseudomonas aeruginosa and Staphylococcus aureus Evaluation of the VITEK 2 system for identification and antimicrobial susceptibility testing of medically relevant gram-positive cocci Comparative study of antimicrobial action of Aloe vera and antibiotics against different bacterial isolates from skin infection Aloe vera and wound healing: A brief review Cosmetics preservation: a review on present strategies Aloe vera gel: effective therapeutic agent against multidrug-resistant Pseudomonas aeruginosa isolates recovered from burn wound infections Antimicrobial activity of Aloe vera extract on cases of keratoconjunctivitisin sheep (in vivo and invitro study) and compared with penicillin–streptomycin Utilization of Aloe vera plants as a raw materials for cosmetics: A narrative review Bacteriophages and the microbiome in dermatology: The role of the phageome and a potential therapeutic strategy Bacteriophage treatment: critical evaluation of its application on World Health Organization priority pathogens Antibacterial activities and antioxidant capacity of Aloe vera Essential oils and their individual components in cosmetic products Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era Download references Open access funding provided by The Science Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB) Open access funding is provided by The Science Department of Basic and Applied Agriculture Sciences Higher Institute for Agriculture Cooperation Higher N’Djamena Institute for Training Teachers responsible for manuscript revision and edited All authors read and approved the final manuscript The authors declare no competing interests The methodology and background of the submitted research were reviewed and approved by the Experimental Animal Care and Research Ethics Committee of Ain Shams University’s Agriculture Sector The study was found to comply with relevant institutional Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-025-86334-y Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma. 2025Yulia PetrovaSave this storySaveSave this storySaveAll products featured on Vogue are independently selected by our editors You’re probably familiar with the skin-soothing properties of aloe vera—especially when it comes to lessening the discomfort of a sunburn. But did you know that aloe vera can also be used for all sorts of skin issues, from psoriasis to dry scalp? In fact, some doctors recommend aloe vera for the treatment of acne and to prevent acne scarring Read on to find out how aloe vera—which is anti-inflammatory and gentle enough to use on all skin types—can make a soothing skin-clearing addition to any beauty routine Aloe vera is a spiny succulent plant that looks similar to agave While it’s originally native to the Arabian peninsula It is also a commonly grown indoors as a potted house plant “Alexander the Great and Christopher Columbus used it to treat soldiers’ wounds.” Inside aloe vera’s spiny stalks, you’ll find a clear, gel-like substance filled with Vitamin B12, protein, and minerals like calcium, magnesium “aloe vera contains 75 potentially active constituents: vitamins and amino acids,” the aforementioned scientific review reports noting that the gel’s fatty acids offer exceptional anti-inflammatory and antiseptic properties “it provides 20 of the 22 human required amino acids and seven of the eight essential amino acids It also contains salicylic acid that possesses anti-inflammatory and antibacterial properties,” the review states “Aloe appears to have anti-inflammatory, antioxidant, and skin-protective qualities, which is why it is often recommended for sunburn,” explains Dr. Paul Benedetto who notes that it also has compounds that promote the growth of new skin cells “Aloe’s physical properties can also be soothing to the skin.” the application of aloe vera gel on the skin “seems to shorten the healing time of first and second degree burns.” it’s no wonder the Egyptians called aloe “the plant of immortality.” a well-known ingredient in the treatment of acne Aloe vera truly is a natural remedy—you can just break open a stalk and use the gel directly from inside the plant. Of course, it’s also available mixed with other ingredients commercially in the form of balms, solutions, and creams. However, most specialists suggest that using gel directly from the plant may be more effective than using a formulated product as its properties will be at less-diluted and thus at optimal strength. Though aloe vera is considered safe and gentle, in rare cases it could cause irritation or an allergic reaction. Therefore, it is always good to test a little on your skin before applying it more liberally. Commercially-purchased gels or cream that contain aloe vera are often less potent and therefore less irritating, but it’s always a good idea to speak to your dermatologist if you have sensitive skin or skin allergies before applying any type of new ingredient. Volume 8 - 2024 | https://doi.org/10.3389/fsufs.2024.1459600 Fresh fig fruits are abundant sources of antioxidants and health-beneficial compounds they are highly prone to spoilage and have short postharvest life the current study aimed to investigate the potential synergistic effect of applying Aloe vera (AV) gel combined with chitosan (CH) as a natural edible coating on fresh fig fruits’ quality and shelf life Different coating treatments; T1—Water; T2—CH (0.5% w/v); T3—AV (100%); T4—AV (100%) + 1% CH (25:75 v/v); T5—AV (50%) + 1% CH (25:75 v/v); T6—AV (50%) + 1% CH (40:60 were applied to fresh fig fruits utilizing dip method Fruits were analyzed weekly to examine fruit weight loss enzyme activity [β Galactosidase and polyphenol oxidase enzyme (PPO)] The combined AV and CH coatings extended the shelf life of the fig fruits up to 21 days compared to the control during storage at 2°C and 90–95% R.H The T5 treatment has significantly retarded the fruit decay preserved total phenolics and flavonoid contents and antioxidant activity (enzymatic and non-enzymatic) T6 fruits showed minimum fruit weight loss and microbial load These treatments can be applied at a large scale to improve the shelf life of fresh fig fruits giving a suitable postharvest treatment to fresh fig fruits is essential to decrease their susceptibility to such incidences that reduce their marketability and shelf-life Adding other materials to the CH can exert both favorable and adverse influences selecting a suitable material for a positive synergetic effect is crucial The application of AV or CH on fig fruits as a standalone treatment has been reported (Mirshekari et al., 2020; Akhila et al., 2022) the literature has no information regarding the combined application the present study investigated the synergistic effect of AV gel combined with CH as an edible coating on fig fruit quality and shelf life during cold storage for 21 days Fresh Aloe vera (Aloe barbadensis) leaves (disease-free) of uniform size were harvested from the AV plants cultivated in the greenhouse at UAE University Fig fruits “Brown turkey” cv. were collected from commercial farms in Al Ain City Fruits were harvested 50% purple skin color (the commercial maturity stage) and immediately were transported to the university laboratory The AV gel was extracted and prepared for coating treatment according to the protocol mentioned by (Kaur et al., 2024). The chitosan stock solution (1%, w/v) was prepared and the pH was adjusted by lactic acid (1%), and then used to make different coating formulations in combination with AV gel (Table 1) All the formulations were kept stable in sterile tubes The homogeneity of the formulations was observed by measuring the absorbance of solutions at 600 nm just after the preparation of solutions absorbance from the lower and upper portions of the solution was taken after 24 h to check the homogeneity Homogenous solutions were used to coat the fruits Uniform fig fruits (in color and size) without defects or mechanical damage were randomly selected and distributed into 6 groups each for one treatment as mentioned in the table above Fruits were given dip treatment for 60 s and then dried at room temperature for 2 h fruits were packed in plastic trays with perforated resealable plastic enclosure and placed in cold storage at 2°C and 90–95% R.H Fig samples (10 fruits) from each treatment were taken out from storage each week for various analyses in triplicates Ten fruits/treatments were retrieved from cold storage weekly and weighed using an analytical balance, and visually checked for any deterioration and counted every week till the end of storage. The weight loss and decay percentages were calculated according to Equations 1 and 2, respectively (Ahmed et al., 2022) The textural analysis of fruits was carried out using CTX USB texture analyzer, Brookfield, (USA), and the probe, trigger, deformation, and speed of penetration applied were 2 mm, 0.0100 N, 5 mm, and 1 mm/s, respectively (Ahmed et al., 2022) Fruit color was recorded using a Hunter Lab colorimeter (Hunter Lab Inc., Reston, VA, USA), and values: L* (Lightness), a* (red, green), and b* (blue, yellow) were recorded every week of cold storage. The Hue angle, Chroma saturation, and Browning Index (BI) were calculated (Hssaini et al., 2021) The total fungal/mold and bacterial counts on fruits were determined before cold storage and at the end of the storage period of 21 days according to the method described by (Kaur et al., 2024) A modified method was adopted to measure fig fruit extract’s total phenolic content (TPC; Velioglu et al., 1998) An aliquot of 100 μl of fig extract was added into test tubes then 50 μl of Folin Ciocalteu reagent and 2 ml of NaOH (6%) The tubes were vortexed and incubated in the dark for 45 min Then the blue color developed was measured using a UV–visible spectrophotometer at 650 nm The results were calculated according to the standard curve of gallic acid and expressed as milligram gallic acid equivalents (GAE) per 100 grams of fresh weight (mg GAE 100 g−1 FW) The total flavonoid content was determined for fig fruit extract according to Kim et al. (2003) an aliquot of 75 μl of NaNO2 (5%) was added to the fig extract (250 μl) and vortexed then incubated for 5 min in the dark 75 μl of AlCl3 (10%) was added; the mixture was kept in the dark for 6 min 500 μl of NaOH (1 M) was added mixed by vertexing and the final volume was made to 2.5 ml with distilled water The absorbance was measured at 510 nm using a spectrophotometer (Shimadzu The results were calculated and expressed as milligram catechin per 100 grams fresh weight basis (mg CE 100 g−1 FW) The scavenging activity of 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical was determined according to the method developed by Blois in 1958 with some modifications (Kedare and Singh, 2011) Different concentrations of samples ranging from 2 to 10 mg ml−1 were mixed with 0.5 ml of DPPH (0.15 mM) in absolute methanol After 30 min incubation in the dark at room temperature A blank was prepared for each similar concentration except that methanol was utilized instead of a DPPH solution Each sample’s standard curve was prepared to calculate the IC50 (Half maximal inhibitory concentration) value (milligrams per milliliters of concentrated fig extract) The radical scavenging activity of 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) was determined by using a modified method (Khadhraoui et al., 2019) Stock solutions of ABTS (7.4 mM) and potassium persulphate (2.6 mM) were prepared Samples (150 μl) with concentrations ranging from 0.5 to 10 mg ml−1 were combined with 2,850 μl of ABTS solution and left at room temperature for 2 h in the dark The absorbance was then measured at 734 nm The activity was recorded and calculated according to a Trolox standard curve ranging from 50 to 600 μM and expressed as milligrams of Trolox equivalents (TE) per 100 grams fresh weight basis (mg TE 100 g−1 FW) A modified method was utilized to extract the β Galactosidase enzyme from fig fruits and to assess its activity (Rastegar et al., 2012) 5 grams of fig fruit tissue was homogenized in a sodium acetate buffer (50 mmol L−1) and sodium chloride (1 mol L−1) and polyvinylpolypyrrolidone (12 g L−1) the mixture was stirred for 3 h at 4°C Then centrifuged (7,500 rpm) at 4°C for 35 min the supernatant (crude enzyme extract) was collected and used for enzyme activity measurement For β Galactosidase activity analysis 50 μl of sodium acetate buffer (0.1 M pH 5.2) and 50 μl of р-nitrophenyl-β-D-galactopyranoside were pre-incubated at 37°C for 15 min Then 50 μl of crude enzyme extract was added to the above mixture and allowed to react for 30 min at 37°C The reaction was stopped by adding 200 μl of sodium carbonate solution (0.5 M) Production of free р-nitrophenol was measured at 400 nm in a Multiskan™ FC (Thermo Fisher Scientific and β Galactosidase activity was expressed as units per gram fresh weight of fruits Fig fruits’ polyphenol oxidase enzyme (PPO) activity was determined every week (Daas Amiour and Hambaba, 2016) Fruit tissue (5 g) was homogenized in phosphate buffer (50 mM pH 6.8) containing 12 g L−1 polyvinylpolypyrrolidone and stirred for 30 min at 4°C The clear supernatant was collected after centrifuging the samples at 4°C for 30 min and labeled as crude enzyme extract crude enzyme extract (10 μl) and freshly prepared 20 mM catechol (50 μl) were added to 96 well-plate and then kept at 37°C for 30 min PPO activity was measured at 398 nm in a Multiskan™ FC Microplate Photometer The results were expressed as units per gram fresh weight of fruits Fig fruits’ peroxidase enzyme (POD) activity was measured every week using a modified method (Zeyadi, 2019) Five grams of fig fruit tissue was homogenized in Tris–HCl buffer (50 mM pH 7.5) containing 12 g L−1 polyvinylpolypyrrolidone and stirred for 30 min at 4°C and the clear supernatant was collected to measure enzyme activity the reaction mixture containing 50 mM sodium acetate buffer sample (pH 5.2) and 8 mM H2O2 was prepared and incubated at 37°C for 30 min and absorbance reading was taken at 470 nm utilizing a Multiskan™ FC Microplate Photometer The results were calculated and expressed as units per gram of fresh fruit weight where one unit of peroxidase is the amount of enzyme that reduces 1.0 μM of H2O2 per minute at 37°C T3 (AV alone) coating was found to be the least effective compared to other coatings Effect of different edible coatings on weight loss of fig fruits during cold storage Means with different letters in the column for each treatment are significantly different at p ≤ 0.05 using the Fisher LSD test Values are the mean (n = 10) ± SE Color is an essential visual attribute of food, especially for fresh fruit, that has a direct impact on the product attractiveness and acceptability by the consumers. Therefore the effect of CH and AV-based coatings on the color characteristics: L* (Lightness), Hue angle, Browning index, and Chroma (saturation) of fig fruits during cold storage are presented in Figure 2 color parameters the fruit were significantly impacted by the application of the edible coating A color transition from dark purple to nuanced brown was observed in all the fig fruits during storage discernible through a decrease in L* and chroma values T6 fruits showed more color transition compared to the control fruit andother treated fruits and T5 fruits showed the least color change Effect of different edible coatings on fig fruit color parameters: L* In the present study, a gradual reduction in firmness was observed in all the fruits with significant differences (p ≤ 0.05) within the treatments and the storage days (Figure 3) The control fruits (T1) showed a substantial loss in firmness from day zero to the end of the storage period (2.16–1.38 N) concerning the other treatments T4 (2.32–1.906 N) and T5 (2.33–1.94 N) coatings considerably preserved the fruit texture and performed better than T2 and T6 and the control till the end of the cold storage While no significant differences were noticed in the texture of T2 (2.18–1.63 N) and T6 (2.05–1.65 N) treated fruits The results suggest that T4 and T5 treated fruits are the best treatment for maintaining fruit firmness Effect of different edible coatings on fig fruits texture during cold storage To determine the effect of edible coatings on fruit firmness, β galactosidase activity was measured in fruits every week and results are presented in Table 2 It is observed that the enzyme activity was first elevated from day 0 to day 7 in all fruits except T1 the highest activity was found in T5 (77.0 U g−1 FW) followed by T4 (76.7 U g−1 FW) and T2 (62.6 U g−1 FW) in decreasing order all treated fruits showed decreased enzyme activity except T1 (control) and then the enzyme activity increased for all fruits where it remained unchanged on day 21 of storage The present study examined the effect of CH and AV-based coatings on preventing the microbial degradation of fig fruits. The visual inspection of fruits was done to detect the fermentative smell, mold appearance, and any other visible disorder, and the results were expressed as fruit decay percentage (Figure 4) The data showed significant differences between different treatments and storage times on fruit deterioration Effect of different edible coatings on fruit decay index during cold storage at 2°C (90–95% R.H.) for 21 days the fruits started to degrade on the 14th day of cold storage in all treatments and by the end of the storage severe symptoms of spoilage were found in T1 fruits (50.3%) followed by the T3 (33%) whereas all other treated fruit had lower decay percentage with T5 fruits the least symptomatic (3.0%) At the end of the experiment after 21 days of cold storage which means that the shelf life of the fruit had increased by 7–10 days after the T5 treatment To evaluate the total microbial load in the fig fruit, the total fungal count and bacterial count were measured before and after cold storage, and the results are presented in Figure 5 Overall results depicted the surge in the microbial count from day 0 to day 21 of cold storage the fruits coated with CH and AV had less fungal and bacterial growth than the control (T1) the initial ranges for total bacterial and fungal counts ranged from 3.77 to 4.62 and 3.4 to 4.10 Log10 CFUg−1 FW then it reached 5.82–6.68 and 4.82–6.83 Log10 CFUg−1 FW It is observed that all treatments including chitosan have lower bacterial and fungus growth with T5 fruits showing the minimum microbial load (4.17 4.82 Log10 CFUg−1 FW) as compared to T1 the control (6.67 no significant difference was found between T1 (control) and T3 (AV-treated fruit) at the end of the storage period Different edible coatings’ effect on fruits’ microbial load during cold storage at 2°C (90–95% R.H.) for 21 days Means with different letters on the bars for each treatment are significantly different at p ≤ 0.05 using the Fisher LSD test The current study evaluated the effect of coatings made of CH and AV in preserving the quality of fig fruits during storage. The results showed that the coatings preserved fruits’ phenolics and flavonoid content until the end of storage (Table 3) Overall results depicted that the applied coatings have modulated the phenolic and flavonoids The T1 (control) fruits were found with reduced TPC and TFC from the beginning and throughout the cold storage whereas the T6 fruits showed the highest TPC and TFC with 410.8 mg GAE 100 g−1 FW and 67.3 mg CE 100 g−1 FW no significant differences were found in the TPC for rest of the treatments the T6 treatment reduced the phenolic and flavonoid content at day 21 T5-treated fruits showed the highest TPC and TFC with 427 mg GAE 100 g−1 FW and 73 mg CE 100 g−1 FW the POD activity got elevated in treated fruits compared to the control fruits and gradually increased with storage time T5-treated fruits had the highest POD activity (77.3 U g−1 FW) compared to the other treatments and the control T1 (33.4 U g−1 FW) The PPO activity was comparatively higher at day 0 and then it started to decline with the storage time irrespective of the treatments No significant differences were observed in the PPO activity within the treated fruits throughout the storage period These biplots gave a clear picture of the whole experiment (A) Principal component analysis (PCA) Biplot for the effect of postharvest application of different Treatments on various physicochemical and quality parameters of fig fruits during cold storage (B) Principal component analysis (PCA) Biplot for the effect of storage days on various physicochemical and quality parameters of fig fruits (Treated and non-treated) 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic) acid; IC50 half-maximal inhibitory concentration; FWL total bacterial count; and TFC = total fungal count the T5 [50% AV + 1% CH (25:75 w/v) have significantly preserved the physical properties of the fig fruits during cold storage The coatings have prevented moisture loss from the fruits thereby preserving the fruit’s firmness until the end of storage Edible coatings have been proven to be highly effective in preserving the antioxidants in fruits AV gel (50%) combined with CH (1%) in a 40:60 ratio could not preserve the TPC and TFC content by the end of storage better results were found in AV gel alone and other combinations with CH the treatments improved the TPC and TFC in fig fruits till the end of cold storage The current results showed that the treatments applied on fig fruits have increased the POD activity and reduced PPO activity during cold storage it could be inferred that the CH and AV gel combinations as an edible coating are promising in maintaining the quality and extending the storage life of fig fruits The treatments utilized in the current study have significantly improved the shelf life of figs by delaying the fruit weight loss and microbial load on fruits during the cold storage for 21 days all coating compositions have positively affected the fruit performance during storage however the T5 treatment (50% AV + 1% CH (25:75 v/v)) performed better than the other treatments across the storage period The T5 treatment significantly reduced the microbial load on fruits and retarded fruit decay the T5 treatment improved the fruit’s phenolic and flavonoid content and its antioxidant activity Whereas T6 (50% AV + 1% CH (40:60 w/v)) treatments protected the fruit from weight loss till the end of storage This study concludes that the coatings: T2 (CH (0.5% and T6 (50% AV + 1% CH (40:60 v/v)) can be used at large scale for improving the shelf life of fig fruits these treatments can be tried on other perishable fruits to observe their broad-spectrum effects The original contributions presented in the study are included in the article/supplementary material further inquiries can be directed to the corresponding author The author(s) declare that financial support was received for the research This research was funded by United Arab Emirate University (UAEU) through the Asian Universities Alliance Joint Research Program (AUA-UAEU) in collaboration with Malaya University The authors are thankful to UAEU for funding this project The appreciation is also extended to the College of Agriculture and Veterinary Medicine The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Protective effects of chitosan based salicylic acid nanocomposite (CS-SA NCs) in grape (Vitis vinifera cv Carboxymethyl cellulose from Banana rachis: a potential edible coating to extend the shelf life of strawberry fruit Synergistic effect of dipping in Aloe vera gel and mixing with chitosan or calcium chloride on the activities of antioxidant enzymes and cold storage potential of peach (Prunus persica L.) fruits Use of novel postharvest Aloe vera gel coating for suppression of ripening changes in Asian pears during long-term cold storage Chitosan coating: a postharvest treatment to delay oxidative stress in loquat fruits during cold storage Chitosan coating to preserve the qualitative traits and improve antioxidant system in fresh figs (Ficus carica L.) and calcium chloride have a synergistic effect on quality and storability of date palm fruit (Phoenix dactylifera L.) 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Received: 05 July 2024; Accepted: 15 November 2024; Published: 27 November 2024 Copyright © 2024 Kaur, Somasundram, Razali and Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Zienab Fawzy Reiad Ahmed, emllbmFiLmFobWVkQHVhZXUuYWMuYWU= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Metrics details This study presents an investigation of the chemical composition of Aloe vera leaf tissue with a focus on the spatial distribution of compounds The composition was studied using two mass spectrometry imaging techniques: silver-109 nanoparticles assisted laser desorption/ionization mass spectrometry imaging (109AgNPs-LDI-MSI) and laser ablation-remote atmospheric pressure photoionization/chemical ionization mass spectrometry imaging (LARAPPI/CI-MSI) and the identification was aided by ultra-high-performance liquid chromatography and ultra-high-resolution mass spectrometry (UHPLC-UHRMS) analysis The results showed an abundance of phenolic compounds with antioxidant making it a beneficial food additive and food packaging material Analysis of the results of mass spectrometry imaging provided information about the potential changes in metabolic pathway expression in different regions of the leaf require that the extract of the homogenized sample is used which results in a loss of information about the location of identified compounds Mass spectrometry imaging (MSI) allows for the detection of various compounds in the analyzed sample resulting in the acquisition of data in the form of ion images with the spatial location of each compound in the sample The preparation of tissue with highly varying structural integrity regions poses technical difficulties due to differences in sample material desorption especially in the gel region where the low concentration of compounds other than water makes it difficult to detect or image certain molecules Various techniques provide the possibility of desorption and ionization in MSI analysis so it’s important to choose the method most suitable for the desired results and sample type The most common techniques are desorption electrospray ionization (DESI) most notably matrix-assisted laser desorption/ionization (MALDI) This in turn is connected to imaging of a smaller size of the sample region the whole cross-section of a leaf was analyzed The method is also regarded as a hard ionizing one meaning that fragments of precursor ions are produced alongside molecular ions For the analysis of complicated biological systems with a variety of compounds The process of sample preparation for MALDI-MSI is time-consuming and complicated as the tissue has to be sliced to the width of ~ 10 μm and homogeneously covered with the used matrix This technique allows for MSI analysis of tissues in a close-to-native state after freezing a sample without any previous preparation The superficial resolution of the technique is 140 μm and the depth of sampling is from 100 to 300 μm depending on the sample and pulse energy LARAPPI/CI system is capable of 2D as well as 3D imaging two very different MSI methods: 109-silver nanoparticles assisted laser desorption/ionization mass spectrometry imaging (109AgNPs-LDI-MSI) and LARAPPI/CI-MSI were used to determine the A The identification was aided by UHPLC-UHRMS + MS/MS analysis of the extract from the plant tissue This is the first work that contains the comparison of nanoparticles-based laser mass spectrometry imaging with chemical ionization/photoionization-based imaging of plant tissue A silver-109 isotope of 99.7% isotopic purity was bought from Trace Sciences International (USA) except for water (18 MΩcm water produced locally) The plant used in this study was initially purchased from a local store in Rzeszow The analyzed samples for MSI analyses were cross-section slices of A vera (L.) leaf obtained from a 5-year-old potted plant which had been cultivated under indoor conditions in southern Poland for two years following its purchase The age of the analyzed leaf fragment is estimated to be 2 years (± 3 months) A leaf was collected from the middle section of the plant and transported at 4 °C It was analyzed within 10 min of collection vera leaf was cut at one-third of its length from the tip the entire cut section was used to create a cross-sectional imprint on the steel plate (LDI target plate) a 3.75 mm thick slice was prepared by cutting with a blade from the region of the leaf adjacent to the one used for imprinting (for LDI-MSI) then placed on the stainless steel plate and frozen vera material from the leaf region adjacent to that used for MSI analyses was used Steel plates used for LARAPPI/CI-MSI as well as LDI targets were fabricated from H17 stainless steel and underwent a thorough cleaning process prior to MSI The cleaning involved sequential soaking in boiling solvents and deionized water (each solvent was used three times in 100 mL volumes for 30 s per plate) the plates were dried under high vacuum conditions (approximately 0.01 mbar) for 24 h Optical photographs were made with the use of an Olympus SZ10 microscope equipped with an 8 MPix Olympus digital camera and also a Canon 6D camera with a macro-type 90 mm focal length lens vera leaf material was homogenized with 1050 µL of 3:1 acetone/water (v/v) mixture in a bead homogenizer the samples were placed at a temperature of -20 °C for 20 min the samples were centrifuged for 10 min at 9800 x g The supernatant was then transported to Eppendorf vials and dried in a SpeedVac vacuum concentrator for 18 h The samples were weighted after drying and 100 µL of methanol was added per every 1 mg of the dried extract Samples were then centrifuged again in 9800 x g for 5 min 100 µL from each vial was placed in HPLC vial inserts and inserted into a Bruker Elute autosampler The samples were in a thermostated autosampler at 4 °C during the analysis Measurements were performed using a Bruker Autoflex Speed time-of-flight mass spectrometer in reflectron positive ion mode The apparatus was equipped with a Smart Beam II 1000 Hz 352 nm laser Laser impulse energy was approximately 100–190 µJ and deflection was set on m/z lower than 95 experiments were made with 2000 laser shots per individual spot All spectra were calibrated with the use of silver ions of 109Ag+ to 109Ag13+ formula a 3.75 mm thick slice from the same region of the A vera leaf was placed on a clean stainless steel plate The plate was then mounted on the stage with a Peltier cooling plate (TE-127-1.4-1.5; TE Technology This ensured the sample remained frozen throughout the laser ablation process minimizing the risk of compound mixing on the sample surface tunable OPO laser (Opolette HE 2940; Opotek USA) was used to generate mid-infrared (mid-IR) laser pulses The laser system produced shorter than 7 ns pulses with a maximum repetition frequency of 20 Hz The laser was tuned to emit at a wavelength of 2.93 μm The pulse energy of the laser-measured before focusing lens was 2.0 mJ The process of laser ablation was conducted in an airtight chamber pressurized with nitrogen gas at a steady flow of 9.5 L/min The mass spectrometer used for the analysis was Bruker Impact II operating in negative ion mode The ionization was conducted using Bruker VIP HESI ion source in the APCI configuration The ion source additionally had a VUV source (Hamamatsu L12542) mounted to the MS sampling cone to induce photoionization A binary HPLC pump (Agilent G1312A) was used to provide a steady flow of a solvent mixture (1% toluene in methanol; 200 µL/min) to the APCI needle The laser ablation plumes were transported to the ion source through a PTFE tube connected to the ablation module The analyzed region encompassed the whole leaf slice The spatial resolution chosen for the analysis was 200 μm To ensure accurate alignment of each pixel the delay between the shots in one line was 1 s The analysis of the results of the imaging was done using software made specifically for the used system These images are included in the Supplementary Information as the study focused on comparing the two imaging methods based on compounds detected by both techniques The ion images presented in Fig. 1 demonstrate the spatial distribution and signal intensity of eight metabolites in A vera tissue obtained using two complementary MSI methods: 109AgNPs-LDI-MSI and LARAPPI/CI-MSI The structures of these compounds were confirmed through UHPLC-UHRMS analysis of leaf extracts The comparison highlights significant differences in the sensitivity and localization capabilities of the two methods The observed differences in spatial distribution between the adaxial and abaxial surfaces may result from differential light exposure which could influence the accumulation of hydroxycinnamic acids based on their photoprotective roles The photos taken of the sample material: (A) The A vera plant used to acquire samples for the study (C) the image of the imprint used for the 109AgNPs-LDI-MSI analysis (D) the image of leaf slice used in the LARAPPI/CI-MSI analysis The compounds identified by the three mentioned analytical methods: (E) 3-coumaric acid the left-ion image is for the imprint technique and the right-ion image for ablation The findings in this study align with prior reports of gluconic acid distribution in plant tissues characterized by distinct epidermal regions and a highly hydrated gel layer urge to consider the specific context for these observations which confirm its predominant localization in the abaxial epidermis of A Given the identification of numerous secondary metabolites derived from the shikimate pathway in A the occurrence of shikimic acid in this sample is consistent with its known role in plant metabolism but this study displays its first identification in the Aloe genus Although sorbifolin has not been extensively studied and no prior MSI analyses have been reported its consistent localization in the abaxial epidermis suggests a protective role against environmental stressors consistent with the known functions of flavonoids in plants 109AgNPs-LDI-MSI showed the highest intensity in the adaxial epidermis while LARAPPI/CI-MSI localized them to the abaxial epidermis Naringenin showed stronger signals and a better signal-to-noise ratio in 109AgNPs-LDI-MSI with some detection in the lower leaf region Metabolites identified by both LDI-MSI and LARAPPI/CI-MSI: (A) 2-Allyl-1,4-dimethoxy-3-methyl-benzene, (B) aloein aglycone, (C) apigenin-7-glycuronyl, (D) – arabinose, (E) 3-caffeoyl-5-coumaroylquinic acid, (F) chrysoeriol-7-glucoside, (G) ethyl citrate, (H) – 8-glucosyl-7-methyl aloesol. For each compound, the left-ion image is for the imprint technique and the right-ion image for ablation. Metabolites identified by both LDI-MSI and LARAPPI/CI-MSI: (A) heptanol When preparing a sample for MSI using the LARAPPI/CI method as it only requires placing tissue of nearly any thickness onto the target plate The sample is frozen using a Peltier module ensuring stability and immobility throughout the analysis The LARAPPI/CI system employs a distance sensor functioning as a surface profilometer enabling precise control of the ablation height during experiments which ensures accurate removal of tissue layers achieved through diffractive optical elements ensures uniform material removal and reduces the formation of artifacts Unlike conical beams that create deeper craters and can result in overlapping ablation zones the flat-top profile ensures precise material removal with minimal distortion sample thickness does not significantly affect the resolution of MSI as the key process is the transfer of chemical compounds from the sample surface to the plate rather than the analysis of the entire sample volume It is possible to achieve instruments maximum resolution however it is not practical for larger objects as imaging time is very long The common practice in our surface transfers is to observe imprint in high magnification optical microscope to assess practical resolution of the transfer and set MSI resolution accordingly The 109AgNPs-LDI-MSI method employs metal nanoparticles as a surface-assistance utilizing their localized surface plasmon resonance (LSPR) to enhance absorptive properties This phenomenon increases the signal intensity for molecules absorbed on the nanoparticle surface making it particularly effective for analyzing small molecules this method demonstrates a higher sensitivity enabling the detection of compounds not visible with LARAPPI/CI-MSI 109AgNPs-LDI-MSI reveals the presence of some compounds in lower concentrations in the inner part of the leaf a feature that complements the more surface-oriented imaging of LARAPPI/CI-MSI The comparison of the two MSI methods highlights that most detected compounds are concentrated in the epidermis as expected given the high water content (95–98%) of the A The post-analysis image of the leaf after LARAPPI/CI-MSI analysis suggests that the ablation was uniformly conducted across the whole leaf slice Both methods operate in a similar m/z range and detect a comparable number of amino acids and carbohydrates LDI-MSI excels in the identification of lipid compounds detecting over twice as many as LARAPPI/CI-MSI whereas LARAPPI/CI-MSI outperforms in detecting aromatic compounds LARAPPI/CI-MSI provides much higher spectral resolution allowing for much higher quality of identification LDI-MSI provides less extensive data for pathway mapping but excels in detecting lipids and other small molecules absorbed on nanoparticle surfaces the spatial localization of compounds between the two methods is largely consistent The complementary strengths of these techniques enable a more comprehensive analysis of plant tissues with LARAPPI/CI-MSI offering superior spatial resolution and enhanced precision for plant-specific metabolites and pathway mapping while LDI-MSI provides deeper insight into lipid distributions and small molecule detection these methods contribute valuable information on the metabolic activity and structural organization of A with minimal compromise in spatial resolution or accuracy even in highly hydrated tissues LARAPPI/CI-MSI was selected over 109AgNPs-LDI-MSI due to its much higher spectral resolution and superior ability to detect plant-specific metabolites The enhanced resolution of QToF instrument used for LARAPPI/CI-MSI enables more detailed visualization of compound localization and intensity which is essential for accurately reconstructing metabolic pathways and identifying the spatial organization of key reactions Ion images obtained by LARAPPI/CI-MSI of compounds present in PPP The fragment of the pathway was presented for comparison of the location of compounds in the pathway in A vera leaf; 6PGL – 6-phosphogluconolactonase Ion images obtained by LARAPPI/CI-MSI of compounds present in A - phenylpropanoid biosynthesis pathway and B - flavonoid biosynthesis pathway The fragments of the pathways were presented for comparison of the location of compounds in the pathway in A CYP98A (C3’H) − 5-O-(4-coumaroyl)-D-quinate 3’-monooxygenase HCT – shikimate O-hydroxycinnamoyltransferase the phenylpropanoid and flavonoid biosynthesis pathways illustrate the plant’s adaptive mechanisms to environmental stress and its metabolic coordination across different tissue regions The study allowed for the identification of key A The identified compounds show properties that confirm the usefulness of Aloe extracts in medicinal The ion images obtained from the two laser ablation-based MSI methods proved that the majority of the compounds were identified in the skin or latex regions of the plant leaf Further analysis of potential metabolic pathways based on acquired ion images proved the metabolic processes identified undergo in the epidermal part of the A The specific structure of the leaf seems to confirm acquired results The difference in the used desorption/ionization techniques showed slight discrepancies in the location of the compounds identified with both methods Since the majority of the compounds identified with ion images showing their occurrence in the gel region have not been previously identified in that part of the leaf the probable explanation is the effect of drifting of compounds during imprinting due to high moisture levels The novel LARAPPI/CI-MSI technique proved to be preferential in the detection of plant-related metabolites and the 109AgNPs-LDI-MSI performed better in lipid detection The integration of three distinct analytical platforms enabled a comprehensive and highly efficient visualization of metabolites in an aloe leaf cross-section providing deeper insights into its metabolic processes This multi-platform approach facilitated a more detailed understanding of the tissue’s biochemical landscape The data sets generated during and/or analyzed during the current study are available from the corresponding author upon request and in the RepOD open data repository (DOI: https://doi.org/10.18150/TNVBKJ) By Distribution Channel (Offline and Online) and lipid constituents of Aloe vera flowers Processing of Aloe Vera Leaf Gel: a review Development and evaluation of different beverages from Aloe vera (L.) 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Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis Journal of Neurogastroenterology and Motility Nagpal R. Effect of Aloe vera juice on growth and activities of Lactobacilli in-vitro Moselhy SN, Al-Nashwi AA, Raya-Álvarez E, et al. Physicochemical, microbiological, and sensory properties of healthy juices containing aloe vera gel and probiotics and their antidiabetic effects on albino rats doi:https://doi.org/10.3389/fnut.2024.1328548‌ Hoogenboom TC, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AK. The Effect of Aloe Vera Juice on Liver Enzymes and Hepatic Structure in a Healthy Population Integrative Medicine: A Clinician’s Journal https://pmc.ncbi.nlm.nih.gov/articles/PMC7572145/‌ Guo X, Mei N. Aloe vera: A review of toxicity and adverse clinical effects Journal of Environmental Science and Health doi:https://doi.org/10.1080/10590501.2016.1166826‌ Djuv A, Nilsen OG. Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6 Aloe FAQs National Toxicology Program Study of Orally-ingested Aloe Vera "We Envision Growth Strategies Most Suited to Your Business" Aloe vera is a plant that belongs to the lily family which originates from the Arabian Peninsula It provide remedies for different diabetic Aloe vera is mainly used in the applications there is a rising adoption of healthy lifestyle across different age groups and the consumers are also opting for various organic The interest of the consumers is also changing from high-calorie carbonated drinks to the plant-based drinks that brings several opportunities for the companies to grow According to Fortune Business Insights™, the global aloe vera extract market could be worth USD 5.34 billion by 2032 and USD 2.86 billion in 2024 The market was valued at USD 2.65 billion in 2023 Lily of the Desert is a family-owned company that manufactures nutritional products and several other supplements in Texas the company has grown as one of the best-selling aloe brand in the natural retail stores across the country The main aim of the company is to produce scientifically validated products that are highly efficient and have valuable health benefits to the consumers The company focuses on the aloe products’ quality and also ensure that all the products undergo strict testing for maintaining the quality standards China’s Foodchem specializes in the manufacturing and distribution of the innovative and standard additives and food ingredients The company sells over 800 products and offers solutions to more than 5,000 customers in the animal nutrition The company has also been involved in the manufacturing and supply of aloe extracts and is also exporting the aloe extracts for a period of more than 10 years Calmino Group AB is a healthcare company based in Sweden which concentrates on improving its customers’ well-being with digestive and gastrointestinal disorders the company has introduced a new product to manage irresistible bowel syndrome (IBS) via their brand called PROIBS The initial focus of the company is to manufacturer well-documented and efficient products on the basis of scientific research which is a cosmetics company based in Costa Rica is the extractor of the superior quality aloe vera acemannan The aloe vera acemannan is being used by nutraceutical The company also manually harvests leaves and process them in their original and natural form NaturAloe has been recognized as the company that extracts active ingredient called Acemannan from the aloe plant under NaturManan and the oldest producer of premium quality aloe vera extracts and concentrates in the U.S the company has a strong product portfolio like aloe vera gel The company is present in over 60 countries globally and all the products are produced and certified as organic The company is also committed to the education of its customers and have a team of chemists and scientists to offer free testing facilities for avoiding adulteration cases is an aloe products manufacturer based in Texas The company has over 150 acres of aloe vera fields where all the cultivation activity and planting is done The company is also engaged in private labeling services for different food products and cosmetics and several other materials in bulk to other companies where the products are being used as a raw ingredient for the formulation of other products is one of the largest producers and processers of ingredients made using aloe vera in Texas The company also focuses in the cultivates and quality aloe by using chemicals it later processes aloe vera to produce powders and juices by using the state-of-the-art methods in their research laboratories offers products via its product lines that include CERTIFIED PLUS and ACTIValoe and the products can also be used in the cosmetics the company also showcase their products at various trade shows that can help in boosting the company’s growth is one of the top aloe vera extract companies that supply premium aloe vera-based quality ingredients to the global health & wellness industries the company was further overtaken by Ashland company which is a U.S.-based chemicals company for USD 660 million The company has also secured a GRAS states for the products including gels and powders based on aloe vera that also help in easing their entry into the food & beverage market La Roche – Posay is a famous skincare brand based in London and is also part of L’Oréal The company usually partners with prominent skincare science dermatologists and is also committed toward introducing safe and natural products which are tested and developed by the dermatologists The company also formulates cosmetic products by using aloe vera powder and juices Because of the moisturizing benefits and soothing properties of aloe vera Organic Harvest is an India-based cosmetic company which produces a diverse range of hair care The main aim of the company is manufacture products that are organic the company has also emerged as the only Indian skincare brand due to which the company was awarded as India’s most promising brand and Green Business of the Year the company is also working on expanding its product range and has introduced a new range of aloe vera-based products for its consumers July 2022 – The company has launched its new organic aloe vera-based gels in four different variants There is a growing adoption of a healthy lifestyle across all age groups and the consumers are also adopting the a natural and nutritional beverage for a healthy life There is a high demand for the aloe vera extracts from the food and beverage industry including the aloe vera-based drinks for products +1 833 909 2966 ( Toll Free ) (US) +44 808 502 0280 ( Toll Free ) (UK) +91 744 740 1245 [email protected] feel free to share your research requirements it’s essential to give your skin extra care and ocean surf can all contribute to skin damage having aloe vera plants nearby can offer natural protection against these elements often referred to as the “potted physician,” is a cactus-like plant with long Introduced from Africa to North America in the sixteenth century the English brought aloe vera to Barbados to shield their sailors from prolonged sun exposure research continues to validate the exceptional healing properties of aloe vera Aloe vera gel acts as a mild anesthetic It possesses antibacterial and antifungal properties and stimulates fibroblasts—the skin cells responsible for healing wounds Aloe vera juice can effectively address various digestive conditions and alleviate constipation and gastric ulcers Topical applications of aloe can diminish pain and swelling associated with arthritis Consuming aloe juice may also inhibit the autoimmune reactions linked to certain forms of arthritis Aloe vera serves as a natural treatment for psoriasis and eczema Rinsing the mouth with aloe juice several times daily can heal persistent infections Place a freshly cut slice of aloe over the closed eye then open the eyelid to allow the aloe to coat it This method is effective for removing small particles stuck in the eye Aloe is an excellent treatment that can be applied immediately to cool Blend the gel of a fresh leaf without water to make a poultice for the injury Aloe acts as a powerful expectorant when the lungs are congested Blend the gel of aloe with lemon juice and water Soothes Rashes and Allergic Skin Reactions skin issues like rashes and allergic reactions are common Aloe gel serves as a natural first-aid treatment for these conditions Aloe can be part of a successful program in treating diabetes Aloe juice can be taken several times a day between meals to help heal the pancreas and liver Growing aloe vera at home is straightforward Local nurseries often offer aloe vera plants Potted aloe requires sandy soil and watering once or twice a week Place the plants in an area with good morning sun and partial shade Monthly watering with an organic soluble fertilizer is beneficial Having half a dozen or more aloe plants ensures a steady supply of leaves for use grow around the mother plant and can be transplanted into separate pots to expand your collection Incorporating aloe vera into your daily routine offers a natural remedy for various health concerns Oct 30, 2024When you were younger, chances are your family members swore by aloe vera for healing cuts scrapes or sunburns. It seemed like everybody had an aloe vera plant your relatives may have been on to something because there are many benefits of aloe vera but it's also a powerful addition to skincare routines.  MD to understand all of the reasons to add aloe vera to your skincare over 50 aloe vera as a skincare ingredient is most known for its powerful ability to soothe and calm the skin—so it's well worth a spot in your routine Packed with antioxidants and vitamins, aloe vera hydrates the skin, creating a glowing, youthful appearance at any age. Keep reading for all of the reasons to add aloe vera to your skincare over 50 Related: The One Thing a Skincare Expert Is Begging Women Over 50 to Start Doing which can help prevent and protect against free radical damage," Dr She elaborates that free radical damage is known to accelerate aging Park adds that aloe vera has high contents of Vitamin C which is what makes it it a powerful antioxidant This helps combat oxidative stress in our skin cells Related: I'm an Esthetician, and This Is the #1 Skincare Product I Recommend for Women Over 50 Aloe vera has long been recognized for its anti-inflammatory properties making it an ideal ingredient for soothing and calming the skin Zubritsky highlights that aloe vera is a powerful anti-inflammatory and aids in wound healing due to the presence of polysaccharides—AKA complex sugars that support the skin’s natural healing process.  Aloe vera's anti-inflammatory benefits can be especially beneficial for people dealing with skin conditions or inflammation as it helps reduce redness. By calming irritated skin and reducing swelling aloe vera helps improve overall skin tone and texture Park notes that aloe vera is non-irritating and non-allergenic making it tolerated by even the most sensitive skin types such as rosacea-prone or eczema-prone skin Navigating skincare products with sensitive skin is tough but you can count on aloe vera to calm your skin.  Related: The 20 Best Facial Cleansers for Aging Skin, Tested by Dermatologists and Makeup Artists A 2006 clinical trial from Skin Research and Technology found that freeze-dried aloe vera extract is a natural effective ingredient for improving skin hydration it may be used in moisturizing cosmetic formulations and as a complement in dry skin treatment Zubritsky shares that aloe vera is quite moisturizing as an ingredient so it can aid in relieving dryness. This is thought to be possible through its humectant properties.  Park also emphasizes aloe vera's hydrating power This high water content allows aloe vera to penetrate deeply replenish moisture from within and leave the skin feeling refreshed and revitalized Unlike heavier creams or oils that can sometimes clog pores aloe vera is suitable for many skin types.   aloe vera aids in wound healing due to the presence of polysaccharides – which help to increase collagen synthesis Collagen is the protein responsible for skin's elasticity and structure Using aloe vera in your skincare routine can help stimulate collagen synthesis Related: 5 Essential Tips for Changing Your Skincare Routine Over 50, According to Model Molly Sims Many studies have proven the antifungal properties of aloe vera We told you your relatives were onto something with the aloe vera treatments!  Aloe vera can treat bacterial and fungal infections without harsh chemicals or medicines Its natural antimicrobial properties make it a gentle yet effective remedy for various skin flare ups from minor cuts to fungal irritations.  Accessible and affordable"Aloe vera is a common household plant so fresh aloe vera gel is quite accessible and affordable," Dr Whether you’re purchasing aloe-based products or using fresh gel straight from the plant adding aloe vera to your skincare routine is budget-friendly and convenient it's versatile and perfect for DIY treatments Metrics details This study evaluated Aloe vera extract as a green inhibitor to prevent corrosion in seawater environments vera extract was produced by maceration with methanol–water at room temperature Electrochemical techniques were used to evaluate the corrosion inhibitor effectiveness of the A The morphology of the corrosion products was analyzed by FE-SEM equipped with EDS and AFM FT-IR and LCMS characterized the functional and structural groups in this extract The electrochemical measurements show that A vera extract could effectively reduce the corrosion of API 5L steel in seawater environments Inhibition efficiency (IE) increases with increasing concentration Optimal corrosion inhibition efficiency of around 83.75% (PDP) and 88.60% (EIS) was obtained by adding 300 mg L−1 of extract at 310 K with the highest activation energy being 48.24 kJ mol−1 for the concentration of 300 mg L−1 increasing the temperature and exposure duration reduces the corrosion inhibition efficiency (IE) values; the best exposure period was 30 min with 88.34% IE by a concentration of 300 mg L−1 at 300 K This corrosion inhibition is achieved by the adsorption process of A vera bioactive on metal surfaces with a mixed inhibitor through a physisorption-chemisorption mechanism This finding was confirmed by the smoother surface morphology of the steel treated with A vera extract has the potential to be an environmentally friendly corrosion inhibitor in the seawater environment vera extract's performance in developing eco-friendly corrosion inhibitors that are environmentally and easy to implement in seawater environments Most green inhibitor studies are conducted in acidic or basic conditions; hence vera's potential active compounds are an alternative source to substitute conventional harmful inhibitors vera was extracted using a new maceration technique with a reactor in a methanol–water solution Evaluation of extract performance as inhibitor based on extract concentration and immersion time using electrochemical techniques (open circuit potential and electrochemical impedance spectroscopy) in seawater environment simulated with synthetic seawater media the protection effect and surface morphology were also analyzed by FESEM–EDS and AFM An in-depth analysis of inhibiting mechanism API 5L steel from geothermal industrial pipes was used as the working electrode with the main content of nominal chemical composition (wt.%): 96.17% Fe The electrolyte solution in this work is a synthetic seawater solution made from a mixture of salt powder (Marine Art SF-1 The solution is made by dissolving 38-g salt powder for every 1000 mL The main composition of salt powder consists of 22.1 g NaCl Rct1 and Rct0 represent polarization resistance with inhibitor and without the addition of inhibitors (blank) and EIS) were done at least three times to ensure reproducibility and stability of measurements The steel surface morphology appeared using Field Emission Scanning Electron Microscopy (FE-SEM Jeol Multibeam JIB-4610F) and energy dispersion spectroscopy (EDS) The surface roughness and morphology of the steel were analyzed using Atomic Force Microscopy (AFM Other compounds in the resulting A. vera extract are 2"-O-Feruloylaloesin (3.62) and Natsudaidain (3.88). A summary of compound names, chemical formulas, and molecular weights identified in A. vera extracts is tabulated in Table 1 Figure 3 illustrates the open circuit potential (OCP) diagram of API 5L steel specimens when exposed to synthetic seawater media, both with and without the presence of A. vera extract at different concentrations. Open circuit potential (OCP) curves of API 5L steel specimens in seawater media containing various A. vera extracts. In the absence of A. vera extract, Ecorr experienced initial fluctuations in the first few minutes, finally stabilizing at a value of − 0.709 V after 600 s. The observed potential decrease is consistent with an active surface, which can be associated with electrode corrosion and the formation of corrosion products that do not adequately protect the metal surface. Potentiodynamic polarization curves of API 5L steel in seawater media with various A vera concentrations at various temperatures Nyquist and Bode's plots illustrate the behavior of API 5L steel in seawater media with various concentrations of A. vera extract at different temperatures, as presented in Fig. 5. Nyquist and Bode plots of API 5L steel in seawater media with various A. vera concentrations at different temperatures. Model of circuit used for A. vera extract performance. Langmuir isotherm of the adsorption for (a) PDP data, (b) EIS data, and (c) log Kads plots versus solution temperature. Arrhenius plots of log CR versus temperature The temperature and immersion time effects on API 5L steel in seawater media containing 300 mg L−1 of A such as extracting and isolating bioactive ingredients that prevent corrosion to open future research avenues for developing corrosion inhibitors that are environmentally friendly SEM/EDS results on the API 5L steel surface after immersion (72 h) in a seawater environment 2D AFM morphology profile of steel surface Schematic of (a) active corrosion pit and (b) corrosion inhibition by active extract compounds on steel in seawater environment Based on the findings of the analysis and evaluation of the performance of A vera extracts as green inhibitors on API 5L steel in seawater environment the conclusion points obtained can be described as follows: The electrochemical analysis indicates that A vera extract can successfully reduce the corrosion of API 5L steel in seawater environments by adsorbing on metal surfaces The PDP analysis achieved an optimal corrosion efficiency of around 83.75% and the EIS analysis achieved an optimum of 88.60% with an inhibitor concentration of 300 mg L−1 at 310 K vera extract has a mixed-type inhibitor and tends to be an exothermic reaction with the highest activation energy being 48.24 kJ mol−1 for the concentration of 300 mg L−1 Increasing the temperature and exposure time tends to reduce the corrosion inhibition efficiency (IE) values and the optimum exposure time was obtained at 30 min with 88.34% IE by a concentration of 300 mg L−1 at 300 K The surface morphology of the steel treated with A presenting the efficacy of the active components in the A The dominant components of active substance in A vera extract strongly suspected to be responsible for the inhibition based on LCMS analysis are methyl phaeophorbide and kaempferol-3-O-rutinoside The corrosion inhibition mechanism by extract was initiated by adsorbing the bioactive component onto the steel surface forming a protective layer of iron (physisorption-chemisorption process) This unveiling investigation discovered that A vera extract has the potential to be a green corrosion inhibitor in seawater environments The corresponding author has all the data connected to this work All data or inquiries connected to this study can be acquired by contacting the corresponding author Xu, Y., Huang, Y., Cai, F., Lu, D. & Wang, X. 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RSC Adv. 10(11), 6547–6562. https://doi.org/10.1039/c9ra05654h (2020) Download references The author would like to thank the organic laboratory at the Research Center for Chemistry and the corrosion laboratory at the Research Center for Metallurgy—the National Research and Innovation Agency (BRIN) for supporting facilities and infrastructure This study was supported by the Ministry of Education and Technology as part of the "PDD Research Grant 2023" program under contract number NKB-887/UN2.RST/HKP.05.00/2023 National Research and Innovation Agency–BRIN Research Center for Pharmaceutical Ingredients and Traditional Medicine School of Chemical Engineering and Physical Sciences Department of Metallurgy and Materials Engineering Faculty of Engineering and the Built Environment Postgraduate Program of Materials Science Study Faculty of Mathematics and Natural Sciences Ahmad Royani: main idea (conceptualization) Gadang Priyotomo: analysis and writing review Siti Musabikha: resources and writing review All authors declare and agree that Ahmad Royani is the main contributor to this paper Download citation DOI: https://doi.org/10.1038/s41598-024-64715-z Volume 11 - 2024 | https://doi.org/10.3389/fnut.2024.1328548 The consumption of fruit and vegetable juices is widely recognized as a healthy choice across all age groups and aloe vera are renowned for their functional properties and health benefits we investigated the potential incorporation of aloe vera gel into blended orange and carrot juices We also evaluated the resulting mixed probiotic juices (chemical and sensory aspects) during a 14-day storage period at refrigerator temperature The chemical composition and phytochemical structure of aloe vera gel were examined followed by an assessment of the biological effects of these healthy juices on diabetic albino rats The results indicated improvements in total soluble solids and total sugars with increasing storage duration the study demonstrated that incorporating aloe vera into the natural mixed juices enhanced their phytochemical quality The treatment supplemented with aloe vera gel gave the highest total content of phenolic and flavonoid substances which were 310 mg of GAE/100 g and 175 mg of quercetin/100 g Probiotic strains (Bifidobacterium animalis subsp lactis Bb12 and Lactobacillus acidophilus L10) exhibited good viable cell counts in orange and mixed orange and carrot probiotics juices with viable counts of 7.42–8.07 log CFU/mL the study found that increasing the ratio of orange juice improved the taste while increasing the ratio of carrot juice enhanced the color in juice mixtures Incorporation of aloe vera into mixed natural juices also enhanced the reduction of blood glucose and urea levels while increasing total protein and HDL levels in diabetic rats and aloe vera offer the potential to produce new this study determined that a functional juice with favorable sensory properties can be created by blending 75% orange juice aloe vera demonstrated greater efficacy as an antidiabetic agent in rats Further research is suggested to explore the potential advantages of aloe vera gel and probiotic juices in mitigating diabetes and other metabolic syndromes also known as “good” bacteria play a role in food digestion and nutrient absorption and defense against harmful organisms that can cause illness is commonly found in probiotic supplements and the human gut It is utilized to address various health issues such as respiratory tract infections it is used to manage conditions such as diarrhea although scientific evidence supporting its efficacy in some cases is limited it is worth noting that there is insufficient data to support the use of B Sometimes, Bifidobacterium animalis subsp. lactis is labeled as Bifidobacterium lactis or B. lactis on product packaging. It is crucial to differentiate B. lactis from other probiotics and fermented food products, such as yogurt, kefir, and fermented milk, as they are not interchangeable (45, 46) Gram-positive anaerobic bacterium commonly found in the human body as well as in various fermented foods such as yogurt and milk acidophilus thrives best in acidic environments with pH levels below 5.0 and its optimal growth temperature is 37°C acidophilus are utilized in dairy production due to their potent probiotic properties and Streptococcus thermophilus after a 24-h fermentation at 37°C and subsequent 28-day refrigeration The findings revealed microorganism viability levels at Log 7.79 and 7.57 CFU/g the literature also suggests that providing probiotic-fortified juice to individuals with lactose intolerance who cannot consume dairy products would be highly beneficial and practical there is currently limited information available regarding the effects of fortifying healthy juices with aloe vera gel and probiotics This includes understanding their impact on various physicochemical and organoleptic properties and their potential antidiabetic effects on albino rats this study aimed to blend aloe vera gel with orange and carrot juices to enhance their functional and organoleptic properties while also investigating its potential antidiabetic effects on albino rats The probiotic strains (Bifidobacterium animalis subsp lactis Bb12 and Lactobacillus acidophilus L10) were provided by Chr Results for probiotic counts in juice samples were expressed as log CFU per mL Oranges and carrots were chosen and washed carefully in tap water and the juice was extracted by hand reamer (vegetable juicer) The extracted juice was then filtered directly and used for blending All juices were pasteurized at 85°C for 10 min pasteurized juices were warm-filled in sterilized and cleaned glass bottles (125 ml) The fruit juice was stored in anaerobic conditions at 37°C using an Anaerobe Jar + GasPak System (OXOID) or a Bugbox anaerobic chamber after being injected with Bifidobacterium or Lactobacillus bacteria All samples were incubated with a 24-h-old probiotic culture (>105 CFU/mL) at 30°C for 72 h Bifidobacteria and Lactobacilli colony-forming unit (cfu) counts were performed on samples at regular intervals The juice had 1% of the fructo-oligosaccharide Raftiline added as a prebiotic during 0 and 24 h of fermentation and preserved for 21 d at refrigerator temperature Aloe vera gel was obtained by cutting leaves perpendicularly and mingled in a juice mixer to make it homogenized and smooth it was filtered through muslin cloth and stored at refrigerator temperature until use • T2: 75% orange juice with 25% carrot juice • T3: 95% orange juice with 5% aloe vera gel • T5: 100% orange juice and probiotics All juice treatments were packaged in 200 ml sterile glass bottles and stored at refrigerator temperature until use The value of total flavonoid was accurately determined in triplicate and expressed as quercetin equivalent in mg/L AlCl3 test was used to assess the flavonoid content a total of 300 μL of 5% NaNO2 was added to an aliquot of 500 μL of sample and then 2 mL of 1 M NaOH was added to the mixture Using a UV-Vis Agilent 8453 spectrophotometer (Agilent Technologies The data were given as mg/100 mL of quercetin equivalents The sensory evaluation of natural mixed juices was assessed by 13 members of the staff of the Agri-Industrialization Unit, Desert Research Center (Cairo), and 15 members of the staff of the Food Science Department, Faculty of Agriculture, Zagazig University. A team of panelists was asked to estimate color, taste, odor, textures, and overall acceptability using a 10-point scale as described (62) The panelists were instructed to wash their mouths with low-sodium spring water during the sensory evaluation session and they were encouraged to write down any criticisms of the tested products Plain and treated juices were presented in plastic cups coded with three-digit random codes Each cup contained 100 mL of juice samples freshly removed from the refrigerator The sensory evaluation was conducted using a comparative test with fresh juices as a reference sample The data were collected in specially designed ballots A statistical analysis was chosen to determine the impact of the treatment. All evaluations were approved in triplicate, and the data was described as mean. Significant differences (p < 0.05) were designed using Duncan multiple range tests (76) The mean values and their standard errors (SEM) are presented and GraphPad Prism V5.0 software (GraphPad A significance threshold of p < 0.05 was used for all statistical analyses Chemical and phytochemical composition of aloe vera gel the previously presented data illustrated approximately the same observation of reducing sugars increasing the storage phase led to a marked rise in the total sugar content of all studied juice blends where this increment reached the maximum values at the end of the storage period The marked increase in total sugars might be attributed to the hydrolysis of polysaccharides such as starch Effect of aloe vera and probiotics on the total sugar content of juices during storage interval Effect of aloe vera and probiotics on total soluble solids content in juices during the storage interval Effect of aloe vera and probiotic juice on the pH values during storage T1: 100% natural orange juice; T2: 75% orange juice 25% carrot juice; T3: 95% orange juice and 5% aloe vera gel; T4: 75% orange juice and 5% aloe vera gel; T5: 100% orange juice and probiotics; T6: 75% orange juice 25% carrot juice fermented with probiotics d) is significantly different (p < 0.05) color contrast in orange-carrot subsidized with aloe vera was decreased more than in the control sample at the end of the storage interval Effect of aloe vera and probiotics on color values of juice T1: 100% nature orange juice; T2: 75% orange juice 20% carrot juice and 5% aloe vera gel; T5: 100% orange juice and probiotics; T6: 75% orange juice f) is significantly different (p < 0.05) Effect of total polyphenols (TPC) and flavonoids (TFC) content on aloe vera and probiotic juices during storage interval The viability of LAB strains decreased as the storage period progressed in two treatments Viable counts in the fermented orange juices during storage considering the overall acceptability of samples fortified with probiotics concluded that there were no significant variances in sensual characteristics of freshly prepared probiotics juice samples after 10 h of incubation while orange juice without probiotics cleared the lowest acceptance Effect of aloe vera and probiotics on the sensory evaluation of juice Impact of feeding aloe vera and probiotic juice on the serum blood glucose levels of diabetic rats G1: negative control group fed on a basal diet; G2: positive control diabetic rats; G3: diabetic rats fed on 75% fresh orange juice and 25% fresh carrot juice; G4: diabetic rats fed on 75% orange juice and 5% aloe vera gel; G5: diabetic rats fed on 75% fresh orange juice and 25% fresh carrot juice fermented with probiotics e) is significantly different (p < 0.05) Body weight of diabetic rats feeding on aloe vera and probiotic juices HDL (high-density lipoprotein) cholesterol and LDL (low-density lipoprotein) cholesterol reverted to almost normal levels because of the aloe vera gel Feeding rats on aloe vera gel did not show any important alteration in total protein and albumin when compared with the control group Effect of aloe vera and probiotics juices on serum lipids profile diabetic rats whereas GOT significantly decreased in the treated group (46.33 mg/dl) when compared to the infected group (58.33 mg/dl) Effect of aloe vera and probiotic juices on the Kidney and liver functions of diabetic rats The study demonstrated the possibility of using aloe vera gel and probiotics in orange and carrot juices in addition to evaluating the functional element of the juices (chemically and sensory) during 14 days of storage at refrigerator temperature The present study also revealed the improvement in the physicochemical and sensory properties of healthy juices containing aloe vera gel and probiotics This was reflected by the improvement of total soluble solids and the phytochemical quality with good and acceptable organoleptic properties the study confirmed that adding aloe vera to the natural mixed juices improved sensory attributes The study revealed that increasing the orange juice ratio improved the taste whereas increasing the carrot ratio improved the color this research concluded that aloe vera juice is more efficacious as an antidiabetic agent in diabetic rats the study pointed out that using orange and carrot juice enriched with aloe vera might be promising for treating diabetes while orange and carrot juice fortified with probiotics could also help overcome lactose intolerance Further research on the mechanistic pathways underlying these antidiabetic effects of healthy juices containing aloe vera gel and probiotics should be studied further inquiries can be directed to the corresponding authors This study was conducted with the approval of the approval of the institutional animal care and research Unit Zagazig University (Institutional Review Board Number ZU-IACUC/2/F/339/2022) The study was conducted in accordance with the local legislation and institutional requirements Writing – review & editing This study was supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R23) Princess Nourah bint Abdulrahman University 1. ^Standard A Crossref Full Text | Google Scholar physicochemical and sensory properties of probiotic yoghurt made from whole milk powder reconstituted in aqueous fennel extract Antimicrobial activity of some plant extracts and their applications in homemade tomato paste and pasteurized cow milk as natural preservatives Effect of fermented camel milk containing pumpkin seed milk on the oxidative stress induced by carbon tetrachloride in experimental rats The impact of date syrup on the physicochemical and antioxidant activity of bio-fermented camel milk Remedial action of yoghurt enriched with watermelon seed milk on renal injured hyperuricemic rats Production of a yogurt drink enriched with golden berry (Physalispubescens L) Juice and its 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substrate specificity The structure and regulation of magnesium selective ion channels Agil A and Elmahallawy EK (2024) Physicochemical and sensory properties of healthy juices containing aloe vera gel and probiotics and their antidiabetic effects on albino rats Received: 27 October 2023; Accepted: 10 June 2024; Published: 16 July 2024 Copyright © 2024 Moselhy, Al-Nashwi, Raya-Álvarez, Abu Zaid, Shalaby, El-Khadragy, Shahein, Hafiz, Aljehani, Agil and Elmahallawy. 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Volume 7 - 2020 | https://doi.org/10.3389/fvets.2020.632666 Phytogenic herbal extracts received considerable attention in the broilers industry as friendly alternative substitutes to antibiotics These additives can be included in the food or drinking water to enhance birds' growth rate and well-being the current investigation examined the effect of including Aloe vera gel in drinking water on the growth rate and broilers' antioxidative capacity 1 day old of initial weight = 48.6 ± 1.65 g were divided into three treatments where the control group was fed the basal diet without including Aloe vera gel in drinking water The second and third groups were fed the basal diet and Aloe vera gel was included in drinking water at 1 and 1.5% and feed conversion ratio were significantly improved in birds that received drinking water with Aloe vera gel at 1.5% compared to the control and 1% groups (P ≤ 0.05) The kidney (creatinine and urea) and liver (ALT and AST) function indices of broilers that received drinking water with or without Aloe vera gel showed no significant differences with the control group (P ≥ 0.05) The blood total protein and albumin had higher values in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05) and LDL levels were significantly decreased in the group of birds that received 1.5% Aloe vera gel in drinking water (P ≤ 0.05) The HDL level was higher in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05) The total antioxidative capacity (TAC) and glutathione peroxidase (GPX) showed higher activity in the group of birds that received 1.5% Aloe vera gel while the level of malondialdehyde (MDA) was lower in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05) including Aloe vera gel in drinking water enhanced the growth rate safer alternative substances are highly recommended to control the infection pathogens The most appropriate feed additive strategy is the oral administration through bird feed, which markedly improves the performances (16). The ultimate beneficial effects of Aloe vera gel included in drinking water are not well-described (17). In this sense, Shokraneh and Ghalamkari (18) reported that Aloe vera gel could be successfully added to broilers' drinking water with the possibility of enhancing growth performance this study aims to illustrate the effects of Aloe vera gel included in the drinking water of poultry on the growth performances This study was carried out at the poultry research farm The chemical and biochemical analyses were done in Laboratories of the Animal Production Research Institute The experiments were carried out following the Ethics Committee of local experiment animal care guidelines at the Faculty of Agriculture Diets were formulated to meet or exceed broilers' requirements as declared by the National Research Council (19) (Table 1). A phase feeding program was adopted: starter (1–10 days), grower (11–24 days), and finisher (25–32 days) (Table 1) were provided to the broilers The formulation and chemical composition of the basal diet Aloe vera gel extracted from fresh Aloe leaves (Aloe barbadensis Miller) was prepared by following Shokraneh and Ghalamkari (18) Fresh leaves were gathered from the local garden for the extraction of gel and the Aloe gel was extracted from the leaf manually by making a cut A 10% (w/v) concentrated infusion was prepared by taking 100 g of fresh gel in a glass bottle and a liter of boiled distilled water was poured on it The bottle was shaken for 5–7 min to ensure thorough mixing and kept for 6–8 h at room temperature before use were divided into three treatments; each included four replicates of 10 chicks (floor pens; 10 birds/m2) placed inside a room equipped with a chain feeder system and automatic nipple cup drinker Chicks were raised in a windowed experimental farm The temperature inside the barn was maintained at around 32 to 34°C from day 1 to day 5 post-hatch and gradually decreased to 24°C at 21 days with relative humidity from 50 to 60% throughout the experiment (35 days) All birds were kept under the same managerial conditions Light was provided the whole day with only 1 h cutoff to get them used to the darkness The photoperiod was maintained as a 21-h light/3-h dark cycle The control group was fed the basal diet without including Aloe vera gel in drinking water The individual body weight and feed consumption were recorded every week during the experimental period growth performance and feed conversion ratio (FCR) were determined by the following formula: FCR = Feed intake (g)/Live body weight (g) Live body weight gain (g) was calculated by subtracting the live weight at the beginning of the experiment from the live body weight at the final stage of the experiment Mortality and the clinical health status of all birds were monitored daily and the mortality percentage was calculated as follows: Mortality % = Number of dead animals/Total number of animals at start × 100 blood samples from 18 birds (1 bird per replicate; 6 birds per treatment) were collected from the wing vein immediately before slaughter Blood samples were collected from the wing and jugular veins using insulin syringes (28-gauge needle) under diethyl ether sedation Blood samples were collected in tubes without anticoagulant for serum collection Blood samples were centrifuged at 1,500 × g for 15 min for serum separation and kept at −20°C to be used for determination of the following serum parameters: cholesterol low- and high-density lipoprotein (LDL and HDL) These parameters were measured by a spectrophotometer using standard commercial kits (Biodiagnostic Co. Egypt) according to the manufacturer's instructions The globulin content was calculated mathematically from the difference between total protein and albumin The glutathione peroxidase (GPX) and total antioxidant capacity (20) were analyzed by using Biomerieux Kits (Biomerieux, France) according to the manufacturer's instructions. The concentration of malondialdehyde (MDA) in the serum was determined, according to Nair and Turner (21) Data for all the response variables were subjected to a one-way analysis of variance (SAS Variables having a significant F-test (P ≤ 0.05) were compared using Duncan's Multiple Range-Test Model: Xij = μ + Ti + eij Effect of Aloe vera gel on growth performance of broiler chicken the blood globulin was not impacted by the inclusion of Aloe vera gel in drinking water Effect of Aloe vera gel on the kidney and liver function of broiler chicken Effect of Aloe vera gel included in drinking water on the biochemical blood indices of broiler chicken: cholesterol Bars with different superscripts are significantly different (P ≤ 0.05; N = 4) The total antioxidative capacity (TAC) showed higher activity in birds that received 1.5% Aloe vera gel than the other groups. Simultaneously, the group of birds that received 1% Aloe vera gel had higher TAC than the control (P ≤ 0.05; Figure 2) Effect of Aloe vera gel included in drinking water on the blood antioxidative responses of broiler chicken: glutathione peroxidase (GPX) The activity of GPX was significantly enhanced in the group of birds that received 1 or 1.5% of Aloe vera gel in drinking water compared to the control group (P ≤ 0.05; Figure 2) The level of MDA was lower in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05), without significant differences with those that received 1% Aloe vera gel in drinking water (P ≥ 0.05; Figure 2) The obtained results showed marked growth performance the present study showed enhanced growth rate and immune response in birds treated with Aloe vera gel in drinking water The present study showed enhanced antioxidative condition and blood biochemical derivatives which was not evaluated in the previous studies which can enhance the feed utilization and Another reason may be associated with the difference in the applied levels of Aloe vera and the strain of birds the present study supported the theory that considers oral administration of phytogenic additives through rearing water is more effective than including them in birds' feed which led to the reduction of free fatty acids released from fat tissue to the blood birds treated with Aloe vera gel in drinking water did not suffer from stressors that can impair the kidney and liver functions The current study results illustrated that the inclusion of Aloe vera gel in broilers' drinking water is recommended to enhance the growth performance and feed utilization birds showed enhanced blood biochemical profiles of healthy liver and kidney The blood total protein and albumin values had improved on birds that received drinking water with 1.5% Aloe vera gel and LDL levels were decreased in the group of birds that received 1.5% Aloe vera gel in drinking water The TAC and the GPX showed improved activity while the level of MDA was decreased in birds that received 1 or 1.5% Aloe vera gel the present study reported the role of Aloe vera in enhancing the antioxidative capacity of broilers The raw data supporting the conclusions of this article will be made available by the authors The animal study was reviewed and approved by Faculty of Agriculture All authors contributed to the article and approved the submitted version This study was financed by Taif University Researchers Supporting Project number (TURSP−2020/92) The handling editor declared a past co-authorship with one of the authors MD Olive cake meal and Bacillus licheniformis impacted the growth performance Oxidative stress in the poultry gut: potential challenges and interventions PubMed Abstract | CrossRef Full Text | Google Scholar Nutritional significance of aloe vera (Aloe barbadensis Miller) and its beneficial impact on poultry CrossRef Full Text | Google Scholar Beneficial effects of 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Copyright © 2021 Amber, Nofel, Ghanem, Sayed, Farag, Shukry and Dawood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Mahmoud A. O. Dawood, bWFobW91ZGRhd29vZDU1QGdtYWlsLmNvbQ== In a recent review article published in the journal Foods researchers in Italy and Portugal investigated the diverse biological activities of Aloe vera (AV) emphasizing its potential in both cosmetic and medicinal applications AV is a versatile plant with numerous health benefits that thrive in hot it has been widely used in traditional medicine and has earned the "miracle plant" title Review: Aloe vera―An Extensive Review Focused on Recent Studies Image Credit: tilialucida / Shutterstock The review's conclusions indicate that AV exhibits significant health benefits, including antiviral, antimicrobial, and antidepressant properties, suggesting promising therapeutic avenues for treating various ailments such as skin disorders and prediabetes. Additionally, AV has demonstrated anti-inflammatory making it a comprehensive natural remedy for numerous health issues AV, in various forms, offers several medical benefits across different health conditions. It has potent anti-inflammatory properties, with its extracts showing effects comparable to or better than common anti-inflammatory drugs like diclofenac. AV helps stabilize cell membranes, inhibit protein denaturation, and regulate inflammation-related genes AV extracts are rich in compounds such as polyphenols which provide strong antioxidant effects by reducing free radicals and protecting cells AV also demonstrates significant antibacterial activity against harmful bacteria including those causing peptic ulcers and tuberculosis Its antibacterial properties are linked to compounds such as p-coumaric acid Its antibacterial properties can be enhanced when combined with nanoparticles by inhibiting growth and preventing the formation of germ tubes essential for fungal virulence Studies have shown that AV can inhibit the growth of multiple Candida species AV extracts and nanoparticles are effective against mosquitoes and parasites showing promise in treating malaria and leishmaniasis AV's antiviral properties are also noteworthy as it inhibits the replication of viruses like influenza and potentially Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Research has demonstrated AV's ability to reduce viral replication and plaque formation in various cell cultures AV can be used topically for cold sores and to treat food surfaces to prevent viral infections it is a versatile natural remedy with broad-spectrum health benefits Image Credit: Inna Dodor / Shutterstock AV protects liver and kidney tissues from toxins and oxidative stress promoting detoxification and reducing inflammation Studies have demonstrated AV's protective effects against various hepatotoxins and nephrotoxins in experimental models protecting the heart from drug-induced toxicity and improving heart tissue health Research supports AV's ability to accelerate wound healing AV's laxative properties aid in constipation relief while its soothing effects help manage reflux disorder and irritable bowel syndrome It has prebiotic properties and can be used to preserve probiotic yogurts AV shows promise in managing metabolic and endocrine diseases by improving blood glucose and lipid metabolism Its multifaceted therapeutic properties make it a valuable natural remedy for a wide range of health issues Due to its hydrating and soothing properties It is also utilized in non-alcoholic hand sanitizers for its humectant and healing capabilities AV gel acts as a natural preservative and edible coating on fruits and vegetables enhancing shelf life by reducing ripening and preserving quality through antioxidant and antimicrobial effects The high demand for AV gel-based products generates significant AV-processing waste This waste is often disposed of in landfills or used as fertilizer but sustainable management strategies like transforming it into animal feed Research into the valorization of AV by-products shows potential for obtaining bioactive compounds with additional health benefits Toxicity concerns arise from some of the active compounds in AV which have been linked to liver and kidney damage and genotoxicity Numerous cases of AV-induced acute liver injury have been reported especially in patients with existing health conditions or those taking hepatotoxic drugs such as antioxidant and antimicrobial properties further research is needed to fully understand AV's health impacts and manage its toxic potential AV is a remarkable plant with a wide array of health benefits and applications in medicine underscores the need for further research and careful consideration of its use Posted in: Medical Science News | Life Sciences News | Medical Research News | Pharmaceutical News Priyanjana Pramanik is a writer based in Kolkata with an academic background in Wildlife Biology and economics Priyanjana holds Masters in Wildlife Biology and Conservation (National Centre of Biological Sciences she was a researcher in the field of public health policy focusing on improving maternal and child health outcomes in South Asia She is passionate about science communication and enabling biodiversity to thrive alongside people The fieldwork for her second master's was in the mangrove forests of Eastern India where she studied the complex relationships between humans Please use one of the following formats to cite this article in your essay How Aloe vera's medicinal properties make it essential in medicine 2025 from https://www.news-medical.net/news/20240711/How-Aloe-veras-medicinal-properties-make-it-essential-in-medicine-cosmetics-and-food-products.aspx "How Aloe vera's medicinal properties make it essential in medicine <https://www.news-medical.net/news/20240711/How-Aloe-veras-medicinal-properties-make-it-essential-in-medicine-cosmetics-and-food-products.aspx> https://www.news-medical.net/news/20240711/How-Aloe-veras-medicinal-properties-make-it-essential-in-medicine-cosmetics-and-food-products.aspx Cancel reply to comment Learn how experts are advancing benzodiazepine analysis and detection using insights from the lab discusses how he is addressing today’s medical challenges using the technology of the future Explore how the Radian ASAP mass spectrometer is being used to streamline and enhance seized drug screening you can trust me to find commercial scientific answers from News-Medical.net please log into your AZoProfile account first Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related newsletter content A few things you need to know before we start Read the full Terms & Conditions. Aloe vera is a cactus-like plant with a stunning reputation in the skin-care world. But what is aloe vera juice good for? Maria Laura is EatingWell's Editorial Manager for Nutrition & News. As part of the nutrition team, she edits and assigns nutrition-related content and provides nutrition reviews for articles. Maria Laura's education, experience and clinical hours from Mexico are equivalent to that of a U.S. credentialed registered dietitian. She is an almond butter lover, food enthusiast and has over seven years of experience in nutrition counseling. Aloe vera is loaded with minerals, vitamins, and other good-for-your-body ingredients. As with any topical, there’s a potential for contact dermatitis, resulting in a skin rash on the scalp. “If you have sensitive skin, perform a patch test by rubbing a small amount of gel on the inside of your wrist and covering it with a Band-Aid for a few hours. Wait five days to see if a reaction develops,” advises Dr. Young. Aloe vera gel can last one to two days when stored at room temperature and about a week when refrigerated, just be sure to store it in an air-tight container. “It can remain frozen for up to a year,” says Largman-Roth, who recommends placing the aloe in an ice cube tray so you can pop out cubes when needed. “Aloe vera juice is extracted from the leaf, whereas the gelatinous substance found inside the leaf is mined from the internal roots of the plant,” says Dr. Taylor. “There’s no scientific proof aloe vera can stimulate hair growth, however, a healthy scalp free of excess scale, inflammation, microbes, and oxidative stress—all of which are mitigated by the presence of aloe—would be ideal for optimal hair growth,” says Dr. Young. "Aloe vera could potentially prevent free radical damage on the hair and scalp as aloe vera juice contains polyphenols which are rich in antioxidants,” says Dr. Taylor. “However, the connection between aloe vera’s antioxidants and UV damage control is still developing.” Houseplant enthusiasts have been issued a warning as long as you master its sunlight and watering needs makes for a beautiful and easy houseplant if you have the right know-how A gardening whizz took to TikTok to share her top care tips for the popular plant Cait Khosla (who goes by @caitkhosla on the sharing platform) described Aloe vera as a "no-brainer" for those who are new to houseplants as they require "little to no care" Offering her advice to a particular gardening enthusiast whose Aloe vera is "going to die" Cait shared all you need to know about the plant's sunlight and water requirements The gardening enthusiast explained that Aloe vera benefits from being by a window in "bright Not enough light will cause its leaves to become "leggy" and almost bendy so it's important to strike the right balance as this will burn its leaves," Cait warned the gardening enthusiast advised carrying out this task "less often but thoroughly" The soil should be left to dry out between watering sessions Signs that indicate your watering technique could use some improvement are "shrivelling" (underwatered) or "yellowing" (overwatered) Yellowing could also signify too much sunlight In a deep dive into Aloe vera, GB News previously revealed how to care for the houseplant at home Gardening gurus from the Royal Horticultural Society confirmed that Aloe vera is a "light-loving" plant indirect sunlight" as opposed to direct The experts advised: "Place them near a south or west-facing window where they can receive plenty of light without being exposed to harsh direct sunlight which can cause their leaves to brown." experts agreed that this should be done "deeply but infrequently allowing the compost to dry out completely between waterings" Gardeners were warned that "overwatering is the most common issue with Aloe vera" as it can lead to root rot and fungal diseases Aloe vera owners should reduce watering to a minimum during the winter months as the plant enters a "dormant" period For Britons interested in adding to their houseplant collection, one expert issued a stark warning Sharing the houseplants to "steer clear" of for gardening success a gardening guru named five that should "definitely not" be in your collection Gardeners were also given some top tips on caring for roses and producing "more blooms" This much-adored succulent can do wonders for a host of hair-related conditions—but you have to be careful about where you source from Lauren Wicks is a writer and editor with a passion for food and spends her free time haunting her favorite natural wine shop exploring the best food and wine destinations in the country and hosting dinner parties for friends and neighbors she's likely working through a stack of historical fiction from the 19th and 20th centuries Saleem A, Naureen I, Naeem M, Murad HS, Maqsood S, Tasleem G. Aloe vera gel effect on skin and pharmacological properties. Sch Int J Anat Physiol. 2022;5(1):1-8. doi:10.36348/sijap.2022.v05i01.001 Volume 3 - 2022 | https://doi.org/10.3389/fanim.2022.1028318 are widely used in fish nutrition due to their market availability wide distribution and acceptable nutritional quality soybean meal-based diets cause gut inflammation decreasing both nutrient absorption and growth rates A suitable alternative to avoid these problems could be the application of additives with anti-inflammatory activity to the diet AV) extract was analyzed as a dietary additive to reduce the gut inflammation in Atlantic salmon (Salmo salar) fed with soybean meal (SBM) diet Fish were distributed in four duplicated groups and fed 28 days with fish meal control diet (FM) The fish gut response to these treatments was analyzed in distal intestine by histopathological scores tissue morphometric measurements and immune gene expression parameters The score results in fish fed with SBM-based diet clearly showed enteritis meanwhile fish fed with AV supplemented diet significantly reduced the intestinal SBM signs of damage These findings were associated to reduction of goblet cells number lamina propria thickness and sub-epithelial mucosa size with a significant decrease on pro-inflammatory cytokine il-1β to basal levels similar to those present in fish fed FM diets the administration of AV in salmon diet showed a protective intestinal activity against the detrimental effects of SBM opening the possibility to improve its use as a feed additive in aquafeeds the preliminary AV studies performed in zebrafish may suggest similar results also in salmonids this study aimed to determine the anti-inflammatory capacity of AV dietary supplementation as a way to avoid the SBM adverse effects reported in Atlantic salmon intestinal health The fish were maintained following Chilean Animal Welfare Regulations (N° 20.380) and experimental procedures were authorized by the Ethical Committee of the Universidad Austral de Chile (certificate number 284/2017) in agreement with the National Agency for Research and Development (ANID Chile) guidelines for the use of laboratory animals 30% inclusion level); 3) FM supplemented with AV (FM+AV) and 4) SBM diet supplemented with AV (SBM+AV) All diets were formulated to be isonitrogenous The fish were hand-fed approximately 3% of their weight twice daily (10:00 AM and 4:00 PM) Table 1 Diets nutrient composition and ingredients six fish per tank (12 fish per treatment) were euthanized by an overdose of MS-222 (tricaine methane-sulfonate blood was collected with syringes from the caudal vein and transferred to heparinized tubes for plasma analysis after centrifugation (5 min at 500 x g) distal intestines for RNA extraction were dissected preserved in RNAlater (Ambion®) and stored at -80°C for further assays Fish distal intestine was use for RNA extraction (4 fish per treatment in duplicate) tissue was homogenized with 100 mg of zirconia beads (BioSpec Products) and 500 μL TRIzol (Invitrogen) in a MiniBeadbeater (BioSpec Products) and samples were centrifuged at 10.000 x g for 10 min at 4°C According to the manufacturer’s instructions and purification was carried out using the EZNA Total RNA kit (Omega Bio-Tek) Purified RNA was eluted in nuclease-free water After 28 days feeding with the different dietary treatments histological changes in the intestinal ultrastructure were evaluated 12 h food deprived fish (6 fish per treatment in duplicate) were anaesthetized as described above dissecting a two-centimeter section of distal intestine from each then fixed in Bouin solution and stored at room temperature in the dark 5 µm gut transverse sections were mounted on glass slides and stained with Hematoxylin-Eosin for general morphology and Alcian blue for Goblet cells analysis Each slice contained 12 complete distal intestine sections and four slices were analyzed per treatment The sections were observed under an Olympus BX61 Microscope and the images were taken using a QImaging MicroPublisher 5.0 RVT camera All images were processed with Photoshop CS6 and ImageJ 1.44o showing the representative effects of each treatment The overall enteritis degree value was calculated by averaging the scores of the six separate parameters the more damage or enteritis signs were observed sub-epithelial mucosa (SM) and the number goblet cells (GC) per slice were measured by scanning the slides using Motic Easy Scan Infinity and processed with Motic Digital Slide Server software (Meyer Instruments Inc EG and SM) and the overall enteritis score were analyzed by a one-way ANOVA A means post hoc comparison between diets was made using Tukey test The RT-qPCR data were analyzed and expressed as fold changes; using fish fed with FM and SBM as control and statistically analyzed with Dunnett multiple comparison test All analyses were performed using Graph Pad Prism 6 Software (Graphad Sofware Significance was established for all analyses at p < 0.05 Figure 1 Aloe vera effect on intestinal morphology B) Representative histological sections of the intestine after 28 days trial stained with Hematoxylin/Eosin and Alcian blue (D) Intestinal morphometric measurements between SBM and SBM +AV groups (n =6) The data were analyzed by one-way ANOVA and Tukey test Significant differences are indicated by different letter p < 0.05 Table 2 Score values of the different parameters analyzed to evaluate enteritis Figure 2 Aloe vera effect on immune response markers Relative mRNA quantification of immune response and mucosal barrier genes The data was normalized with ef-1αa and ef-1αb expression The relative transcriptional level was obtained comparing data from SBM with FM (A) Segmented line corresponds to control FM and SBM respectively (C) Complement hemolytic activity (ACH50) and (D) lysozyme activity quantification Statistical analysis was performed with one-way ANOVA and Dunnett test multiple comparison test respect to SBM *p< 0.05; ***p< 0.001; ****p<0.0001 Even though complement activity (ACH50) did not show significant differences between any of the four groups analyzed (Figure 2C), lysozyme activity was significantly lower in the SBM group compared to FM and SBM+AV diets (Figure 2D) these results open the possibility to use AV as a way to complement and optimize the use of SBM and other alternative proteins supplying an anti-inflammatory ingredient for commercial importance species without affecting the production parameters and increasing the sustainability of the future aquaculture feeds industry more studies are clearly needed to provide additional knowledge in order to unravel the different implications and mechanisms of AV on the inflammatory signaling pathways antioxidant response and nutrient absorption processes which will have a beneficial impact on fish health and welfare when incorporating this natural additive in diets the present study demonstrates the intestinal anti-inflammatory effect that AV has in Atlantic salmon fed with a high SBM-based diet AV supplemented diet was able to significantly reduce the intestinal damage signs induced by SBM-based diet These findings were confirmed by histological score associated to a reduce goblet cells number concomitant to a significant pro-inflammatory cytokine il-1β mRNA decrease similar to those present in fish fed fishmeal diets The original contributions presented in the study are included in the article/Supplementary Material The animal study was reviewed and approved by Experimental procedures were authorized by the Ethical Committee of the Universidad Austral de Chile (certificate number 284/2017) did the sampling and analysis of the samples also wrote and validated the final version of manuscript conducted sampling and analysis of the samples in the laboratory and AR contributed with discussion of the results drafting and revising the final manuscript This work was partially funded by the projects FONDECYT 1171357 FONDAP 15200002 and FONDAP 15110027 belonging to Agencia Nacional de Investigación y Desarrollo de Chile (ANID) The authors extend their appreciation to VIDCA Universidad Austral de Chile and ANID Chile for providing the PhD scholarship for KF-C The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fanim.2022.1028318/full#supplementary-material A meta-analysis to determine factors associated with the severity of enteritis in Atlantic salmon (Salmo salar) fed soybean meal-based diets Impact of down-stream processing on functional properties of yeasts and the implications on gut health of Atlantic salmon (Salmo salar) Anti-inflammatory effect of aloe Vera (l) burm @ on COX-2 and histamine expression in mice skin exposed to UVB CrossRef Full Text | Google Scholar Immunostimulatory and protective effects of aloe vera against coccidiosis in industrial broiler chickens Effects of dietary aloe vera on some specific and nonspecific immunity in the common carp (Cyprinus carpio) Google Scholar digestion and absorption of nutrients,” in Fish physiology Google Scholar Bakke-McKellep A inulin and oxytetracycline on intestinal microbiota and epithelial cell stress apoptosis and proliferation in the teleost Atlantic salmon (Salmo salar l.) Bakke-McKellep A Atlantic Salmon (Salmo salar l.) parr fed genetically modified soybeans and maize: Histological Soybean meal-induced enteritis in Atlantic salmon (Salmo salar) and Chinook salmon (Oncorhynchus tshawytscha) but not in pink salmon (O Pathogenesis and immune response in Atlantic salmon (Salmo salar l.) parr experimentally infected with salmon pancreas disease virus (SPDV) In vivo macrophage activation in chickens with acemannan a complex carbohydrate extracted from aloe vera Leukocyte phagocytosis and lysozyme activity in Nile tilapia fed supplemented diet with natural extracts of propolis and aloe barbadensis Effects of aloe vera and sucralfate on gastric microcirculatory changes cytokine levels and gastric ulcer healing in rats Replacing fishmeal with plant protein in Atlantic salmon (Salmo salar) diets by supplementation with fish protein hydrolysate The State of World Fisheries and Aquaculture 2018 - Meeting the sustainable development goals Google Scholar Fehrmann-Cartes K Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish Candida utilis and chlorella vulgaris counteract intestinal inflammation in Atlantic salmon (Salmo salar l) Chitosan and chitooligosaccharides attenuate soyabean meal-induced intestinal inflammation of turbot (Scophthalmus maximus): possible involvement of NF-кB activator protein-1 and mitogen-activated protein kinases pathways Haemato-immunological indices in rainbow trout (Oncorhynchus mykiss) fry fed with aloe vera extract supplemented feed Hamza A. H. K. (2022). Aloe Vera (Aloe barbadensis miller) and its natural ingredients: A mini review. Phytopharmacol. Res. J. 1, 49–55. Available at: https://ojs.prjn.org/index.php/prjn/article/view/11 Google Scholar Soybean meal induces intestinal inflammation in zebrafish larvae Identification of optimal molecular size of modified aloe polysaccharides with maximum immunomodulatory activity In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel Intestinal microbiota of salmonids and its changes upon introduction of soy proteins to fish feed Krogdahl Å. Effects of graded levels of standard soybean meal on intestinal structure and pancreatic response in Atlantic salmon (Salmo salar l.) soybean products: effects on disease resistance (furunculosis) and lysozyme and IgM levels in the intestinal mucosa The potential impacts of soy protein on fish gut health in: Soybean for Human Consumption and Animal Feed CrossRef Full Text | Google Scholar Improved utilization of soybean meal through fermentation with commensal shewanella sp MR-7 Turbot (Scophthalmus Maximus L.) 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Pharmacological update properties of aloe Vera and its major active constituents CrossRef Full Text | Google Scholar Nutritional properties and feeding values of soybeans and their coproducts Production Processing Utilization (Urbana IL USA: AOCS Press) 2008 Zebrafish as animal model for aquaculture nutrition research PubMed Abstract | CrossRef Full Text | Google Scholar Soybean meal-induced enteritis in Atlantic salmon (Salmo salar l.) at different temperatures The impact of acemannan on the generation and function of cytotoxic T-lymphocytes The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus l.) fed soybean meal-based diets Effect of aloe vera extract on the improvement of the respiratory activity of leukocytes of matrinxã during the transport stress Aloe vera enhances the innate immune response of pacu (Piaractus mesopotamicus) after transport stress and combined heat killed aeromonas hydrophila infection Citric acid mitigates soybean meal induced inflammatory response and tight junction disruption by altering TLR signal transduction in the intestine of turbot Dietary effects of soybean products on gut microbiota and immunity of aquatic animals: A review CrossRef Full Text | Google Scholar Hernández AJ and Romero A (2022) Aloe vera reduces gut inflammation induced by soybean meal in Atlantic salmon (Salmo salar) Received: 25 August 2022; Accepted: 26 September 2022;Published: 19 October 2022 Copyright © 2022 Fehrmann-Cartes, Vega, Vera, Enríquez, Feijóo, Allende, Hernández and Romero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Adrián J. Hernández, YWpoZXJuYW5kZXpAdWN0LmNs; Alex Romero, YWxleHJvbWVyb0B1YWNoLmNs YOU don't need to fork out too much cash to have silky smooth skin The budget-friendly store is selling a sought after body lotion for just $1.25 - and it's reportedly just like one loved by celebs The ProSilk Body Aloe Vera Daily Moisturizing Lotion won't break the bank at $1.25 - but you'll also get a lot of bang for your buck The moisturizer currently has some rave reviews online too as one shopper said: "I purchased this product at two of the local stores within two months of each other Hoping more will come available for purchase online And a second agreed: "Smell is awesome Jennifer Anniston is said to be a big fan of the Aveeno brand, but the Dollar Tree alternative can give you the same glow for a fraction of the price. Not only does the body lotion have calming aloe vera, but there's added vitamin E, and no dyes or parabens - so you can soothe your skin stress-free. That's not the only reason to dash to Dollar Tree right now though, the store is known for its incredible dupes - and shoppers recently went wild for a Victoria's Secret dupe. The SPA Luxury Scented Body Wash is available in a range of delicious fragrances and it's Love Struck variety is 'inspired by' Victoria's Secret's fragrance The bargain body wash is specifically formulated with a blend of ingredients that promise to 'cleanse and refresh' the skin Skin feels smoother and softer thanks to the Shea Butter and Vitamin E inside which work together to condition your body And the body wash is a bargain dupe for a classic Victoria's Secret favorite Their Natural Beauty Cream Bodywash is loved by fans for its moisturising properties - as it also contains nourishing Shea Butter The rich cream wash has scored an impressive 4.8 stars from happy customers online However it comes with a much more expensive price tag Dollar Tree's cleansing wash contains similar ingredients at a fraction of the price and been impressed with the gorgeous scent One happy shopper said: "The best body products and my favorite to use." While a third review said: "Your Love Struck is amazing...I would LOVE for it to be at Mississippi Dollar Tree stores all the time.. Savvy shoppers have scoured Dollar Tree to find dupes of their favorite products Shoppers found a perfect replica of a $150 set of Pottery Barn plates and bowls Dollar Tree also had dupes for the viral Starbucks tumblers Customers found dupes for Home Depot's $39 outdoor solar lights Dollar Tree has a dupe for The Pink Stuff cleaning paste 2025 08:00 ISTIn ShortRed aloe vera is marketed as superior to the OG green oneDiscovered in 2019 it's rare and costly to importExperts advise sticking to traditional aloe veraOver the years if there’s one product that has been a staple in almost every makeup bag (whether you’re a beauty enthusiast or not) Known for its hydrating and anti-inflammatory properties and approved by both Ayurvedic and allopathic experts aloe vera has made quite a mark in the beauty industry India is one of the largest exporters of aloe vera in the world But what if we told you there’s a close cousin of aloe vera that supposedly has ‘22 times’ more ‘healing’ properties and is native to the African deserts that’s exactly how many beauty brands are marketing what they call ‘red aloe vera’ the information surrounding this ingredient is only half true the products being sold under the name ‘red aloe vera’ could potentially be a scam.‘Hiding in plain sight’ To understand why experts believe red aloe products in India might be a scam we need to look at how they were discovered various brands are marketing 'red aloe vera’ as a superior version of the commonly available green one and the products are available on platforms like Flipkart and Nykaa These products range from eye creams to red aloe vera gels Now, back to our story of how the red aloe was discovered. Scientific journals state that Aloe sanguinalis, or Somali Red Aloe, has red-coloured leaves and sap (the gooey substance inside aloe vera) was ‘hiding in plain sight’ in an area not typically known for high biological diversity. Locals had long recognised it as different from other “Dacar” (the Somali name for aloes) and referred to it as “Dacar cas” or “red aloe”. However, it was only classified as a distinct species by an environmentalist and a botanist in 2019, making it unique among the 600+ aloe species. Sujit Shanshanwal, dermatologist and medical director of SkinAmour Clinics, Mumbai, states that in his 15 years of experience, he has never come across red aloe vera. “I did some research and realised that red aloe was only recently discovered. The claims that it has better benefits than aloe vera are quite impossible. Since it was only recently identified, there hasn’t been enough time for extensive studies to prove its effectiveness,” he says. Sujit explains that assuming the red aloe vera’ being sold in beauty markets, including India, is superior to regular aloe vera is misleading. There is no scientific study to support these claims. “There are so many species of aloe. Aloe vera (the widely available one) is a succulent plant species of the genus Aloe. We now have various scientific studies proving its benefits, but there’s no such research on red aloe. Some species of aloe actually have drying properties rather than hydrating ones, so it’s wrong to assume red aloe will be any better or have the same benefits as aloe vera,” he says. Dr Chandani Jain Gupta, dermatologist and aesthetic physician at Elantis Healthcare, New Delhi, somewhat disagrees. She agrees that the red aloe vera products sold in Indian markets are a scam, primarily because they are too expensive to be sold at the rates advertised. However, she believes red aloe vera might have some benefits, attributing this to its red colour. In India, you may come across ‘red aloe vera’, which is just the traditional aloe vera plant turning a copper-reddish hue due to excessive sun exposure. Dr Gupta clarifies that these plants have the same properties as regular aloe vera and nothing ‘extraordinary’. As for potential benefits, Dr Gupta says that red-coloured fruits and vegetables are generally rich in antioxidants like lycopene and Vitamin C, which protect the skin from ageing and UV damage. They also boost collagen production, keeping the skin firm and reducing wrinkles. “These foods have anti-inflammatory properties that help reduce acne, redness, and irritation. Similarly, there’s a good chance that red aloe might offer these benefits due to its colour. But again, more studies are needed to confirm this,” she adds. India Today conducted an analysis of products claiming to contain ‘red aloe vera’ and found two key things: the term ‘red aloe vera extract’ appears at the very end of the ingredient list, suggesting it’s not the primary component, and many of these products contain artificial red colouring. “Nowadays, people will market anything as special,” Dr Gupta says. Stick to the OG one 2024Courtesy of brands / Gabrielle LangdonAll products featured on Glamour are independently selected by our editors This is a great natural ingredient option, says Dr. Arora. It’s great for all skin types because it works to alleviate dry and irritated skin while boosting moisture thanks to the inclusion of vitamin E. It also won’t leave your skin feeling greasy or sticky after you apply it, and it provides relief from sunburn and insect bites. Dr. Chacon recommends this gel because it specifically helps those experiencing redness, dryness, and even acne. “It’s cooling, soothing, and hydrating so it will feel really good on your skin and should provide some relief,” she says. “It’s also a vegan formula and fragrance-free, so it’s great for those with sensitive skin as well.” The panthenol (a pro-B5 vitamin) ingredient provides additional moisture. According to Dr. Hayre, a nice feature of this organic aloe gel is hydrating ingredients like ceramides, which can be a game-changer in helping burned or inflamed skin to heal. This 100% vegan aloe vera gel contains manuka honey, cucumber, bitter orange, and other natural ingredients to help relieve irritation from sunburns, acne, or dryness. Plus, it’s completely vegan and free of parabens and sulfates. According to Dr. Arora, this is one of the highest-quality aloe vera gel options out there, with 99% pure aloe vera gel, which is made from organic plants. It’s also free of sulfates, fragrances, and chemicals such as parabens, so it’s an ideal option across the board, particularly for those with sensitive skin. As an added hair care bonus, it can also be used as a hair gel, or even as a leave-in conditioner, boosting softness and shine. This gel stands out because it uses aloe vera juice from fresh aloe leaves rather than from powder “This allows for maximum potency because it is in its purest form,” Dr they use natural thickener seaweed extract which reduces the sticky residue left over.” This gel is also free from artificial additives and fragrances “It generally has a nice soothing effect on the skin “While aloe vera is known for after-sun care for the skin to hydrate, nourish, and soothe the skin, it also is seen in lots of other skin care products for its many benefits,” adds Anna Chacon, MD and helps with inflammation—perfect for those with stressed Aloe vera may also be helpful in reducing inflammation from other types of inflammatory skin conditions like eczema or psoriasis, although it is not helpful at the same level as typical prescription medications for these conditions, says Kristina Collins, MD a double board-certified dermatologist in Austin I think aloe vera is probably most useful as a skin soother when your skin is irritated in a minor way,” she says An official website of the United States government The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches including publications and searches of Federal databases of scientific and medical literature The Clearinghouse does not provide medical advice Telecommunications relay service (TRS): 7-1-1 Website: https://www.nccih.nih.gov Email: info@nccih.nih.gov (link sends email) A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Practices on PubMed Website: https://pubmed.ncbi.nlm.nih.gov/ NIEHS supports research to understand the effects of the environment on human health and is part of NIH Website: https://www.niehs.nih.gov/ Email: webcenter@niehs.nih.gov (link sends email) ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements) Website: https://ods.od.nih.gov Email: ods@nih.gov (link sends email) This publication is not copyrighted and is in the public domain. Duplication is encouraged. NCCIH has provided this material for your information. 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FacebookX© Steven FosterRelated Topics Herbs at a Glance HerbList App Contact Us National Institutes of Health U.S. Department of Health & Human Services USA.gov Privacy and Policies Accessibility FOIA Vulnerability Disclosure NCCIH Website Archive Archive NCCIH Home which will be executed and operated by Magnon Servicios Energéticos will reduce direct CO2 emissions from the factory located in Guadalajara by 95% • With an associated investment of more than 15 million euros the project is part of the company’s decarbonization roadmap which aims to achieve carbon neutrality for all its production centers by 2030 the largest in the country and one of the highest producers in Europe is a benchmark within the sector in process efficiency valorization and responsible consumption of resources a 100% Spanish family-owned beverage company and leader in the brewing sector in our country is advancing on its decarbonization roadmap with an ambitious project that will allow it to reduce direct CO2 emissions from its factory in Alovera (Guadalajara) by 95% This will be done thanks to the collaboration of Magnon Servicios Energéticos start-up and operation of a facility to generate thermal energy from biomass With an estimated cost of more than 15 million euros through its subsidiary Magnon Servicios Energéticos will invest and execute the project at the brewery’s facilities maintenance and supply of thermal energy in the form of superheated water The biomass plant will operate in combination with the existing natural gas installation drastically reducing the use of this fossil fuel by the company The biomass supplied will have the SURE certification which accredits its sustainable supply and production “We are aware of the need to promote changes in the production system and we are moving forward decisively in solutions that allow us to optimize our processes and reduce our environmental impact as much as possible” – says Nicolás Castrejón Director of Operations at Mahou San Miguel – “Within our unique industrial footprint Alovera plays a key role in promoting energy efficiency and self-generation projects that we will extend to the rest of the company’s production centers to achieve carbon neutrality in 2030” – he adds “We are convinced that the decarbonization of industrial thermal demand is one of the great challenges of the energy transition” – explains Lidia Roca General Manager of Magnon Servicios Energéticos – “within the framework of the change in the energy model towards a decarbonized and renewable system the Ence Group offers sustainable energy solutions products and services through the most cutting-edge technologies” The forecast of both companies is to start the execution works in the first quarter of 2025 so that the facility is operational in 2026 More than 220 million euros to promote sustainability The biomass plant at the Alovera factory is one of the 19 projects included in the first line of aid granted by the Ministry of Industry and Tourism within the framework of the Strategic Project for Economic Recovery and Transformation (PERTE) for industrial decarbonisation of our country that will allow a reduction of 551,000 million tons of CO2 per year The plant located in Guadalajara stands out as the largest brewery in Spain ranking in the top 3 in terms of production at European level with a capacity of seven million hectolitres per year This makes it a spearhead and a benchmark in many aspects also due to its optimal environmental performance and the use of innovative technologies and eco-efficient practices The centre has a photovoltaic solar park for self-consumption with an installed capacity of 4.3 MW peak and uses 100% renewable electricity 15% of the thermal energy used in its production is already self-generated and like the rest of the company’s plants it is zero waste thanks to its valorisation and reuse in other processes a key element of industrial decarbonisation One of the identifying features of Ence’s value proposition is its extensive supply capacity as well as its leadership and extensive experience in the comprehensive and sustainable management of biomass through which industrial companies will be able to reduce their CO2 emissions and decarbonise their activity Thanks to Ence’s long history in the operation of biomass energy generation assets its clients can outsource the management of their energy needs allowing them to meet their decarbonisation objectives through a tailored efficient model that produces economic advantages reduces operational risks and has a high-value socio-environmental impact on the territory contributing to the structuring and development of the rural environment We are using cookies to give you the best experience on our website This website uses cookies so that we can provide you with the best user experience possible Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping 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