Bill Belichick has already begun looking ahead towards the 2026 recruiting class New Jersey native is scheduled to visit North Carolina on Wednesday Along with his upcoming visit to Chapel Hill Calhoun will check out Duke University and Wake Forest University around the same time Kevin Cacabelos on X (formerly Twitter) with the report: 2026 RB Najee Calhoun (Bergen Catholic - NJ) @JeeCalhoun has visits scheduled with Wake Forest (3/18), North Carolina (3/19), and Duke (3/20), he tells me. He is also planning to visit Virginia and Harvard.Calhoun had 13 TDs, 1300 yards, and 6 YPC in 2024. pic.twitter.com/K31rp0mIPb Calhoun attends Bergen Catholic — ranking as the No. 67 running back and No. 16 in the state, per 247Sports The current high school junior holds offers from Boston College The incoming class for Belichick contains four running backs — those being Demon June There will be no shortage of bodies in the run game department for UNC in the foreseeable future During the 2024 season Carolina had 125 first downs rushing the ball and gained 2727 yards 26 touchdowns came on the ground (in comparison to 18 touchdowns converted through the air) A big part of the Tar Heels' success was due to having Omarion Hampton's elite talent in the backfield — juking and taking the ball all the way into the end zone it will certainly be hard to find another Hampton but with Belichick and the revamped coaching staff the player development should change drastically it remains to be seen how UNC's new head coach can gel to the college game But the odds of it being a difficult challenge will be towards the lower end of the scale — the guy has eight Super Bowl rings after all North Carolina will kick off the season on Monday Night Football against TCU at Kenan Stadium The event will be shown on ESPN starting at 7:30 p.m © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER ","https://fansided.com/",{"alt":"5z","src":"60","url":"61"},{"type":"5y","value":"62"},"link","Minute Media","https://www.minutemedia.com/",{"text":"65","url":"66"},{"type":"64","value":"67"},"All Rights Reserved Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands 2026 RB Najee Calhoun (Bergen Catholic - NJ) @JeeCalhoun has visits scheduled with Wake Forest (3/18), North Carolina (3/19), and Duke (3/20), he tells me. He is also planning to visit Virginia and Harvard.Calhoun had 13 TDs, 1300 yards, and 6 YPC in 2024. pic.twitter.com/K31rp0mIPb Calhoun attends Bergen Catholic — ranking as the No. 67 running back and No. 16 in the state, per 247Sports During the 2024 season It's never too early to get a head start in the recruiting world and that means official visits are looming the program is expected to host the top class of 2026 recruit in Colorado as Kevin Cacabelos of SeaTown Sports reported on Friday that four-star tight end Camden Jensen will visit UCLA on the weekend of May 16 2026 4-star TE Camden Jensen (Heritage HS - Colo.) @Cam_Jensen97 has on official visit set with Washington (May 2-4), he tells me. Other official visits: UCLA (5/16-18); Missouri (6/6-8); Nebraska (6/13-15); and Florida (6/20-22). pic.twitter.com/BejBBdZIwk The Bruins offered Jensen in August and are one of his top-seven teams who plays for Heritage High School in Littleton 1 class of 2026 recruit in Colorado and the No Jensen also has official visits set up with Washington Texas A&M and North Carolina are his other finalists Rivals highlighted the prospect's strengths in an article from December that listed the top prospect in each state: "Jensen is a massive tight end prospect at 6-foot-7 who can also move well create space or stay in and block as needed maybe he’s a star offensive tackle but he can stay at tight end for now because of his athletic ability." According to Charlie Williams of On3's Inside Texas "Jensen is a reliable red zone target with solid blocking ability making him a true dual-threat option." Jensen is in the same class as four-star tight end Israel Briggs another highly touted tight end who UCLA is pursuing Jensen and Briggs' primary recruiter from UCLA is tight ends coach and assistant head coach Jerry Neuheisel Neuheisel has been working hard on the recruiting trail all offseason Following his first season as the program's tight ends coach he was promoted to associate head coach in December This coming season will be his eighth on staff The future of the tight end position will be key for UCLA, which lost standout tight end Moliki Matavao, who was just invited to the 2025 NFL Combine makes Neuheisel's activity on the recruiting trail all the more crucial Ensure you follow on X (Twitter) @UCLAInsideronSI and @tcav30 and never miss another breaking news story again Please let us know your thoughts when you like our Facebook page WHEN YOU CLICK RIGHT HERE AIDAN CHAMPION Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. Experimental Pharmacology and Drug Discovery Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1010296 The growing interest in the development of drugs that target the endocannabinoid system has extended to conditions that affect the audiovestibular pathway The expression of cannabinoid (CB) receptors in that pathway has been widely demonstrated indicating a therapeutic potential for drug development at this level These medications may be beneficial for conditions such as noise-induced hearing loss or various forms of vertigo of central or peripheral origin The therapeutic targets of interest include natural or synthetic compounds that act as CB1/CB2 receptor agonists/antagonists and inhibitors of the endocannabinoid-degrading enzymes FAAH and MAGL genetic variations implicated in the response to treatment and the development of related disorders such as epilepsy or migraine have been identified Direct methods of administering these medications should be examined beyond the systemic strategy with depressive drugs administered in cases of increased neuronal excitability and stimulants prescribed in cases of decreased neuronal activity The endocannabinoid (EC) system is distributed widely in the brain and is also expressed in the audiovestibular pathway (Gong et al., 2006; Chi and Kandler, 2012; Trattner, Berner, Grothe and Kunz, 2013) There has been increased interest in the development of drugs that act either as an agonist or antagonist on the EC system This review summarizes current understanding on the role of the EC system for the future use and development of natural- or synthetically-derived compounds that act on the audiovestibular pathway it is necessary to fully understand the properties of the EC system and the pharmacogenetic profiles of drugs that act on the EC system More than one hundred CBs derived from the Cannabis sativa plant have been identified. Of these, tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) are the most studied and for which the most clinical data are available (Chandra et al., 2020) The pharmacogenetic profile of cannabinoid derivatives is still under development especially with regard to new synthetic derivatives Dronabinol’s mechanistic genes are CNR1 and CNR2 Nabilone displays the same mechanistic genes as Dronabinol but it binds partially to its receptors; CYP2C9 Profile of the different cannabinoids and drugs that act on the cannabinoid system that may be effective in the treatment of audiovestibular disorders CB1 antagonists such as rimonabant, surinabant and other diarylpyrazole derivatives have been experimentally and clinically evaluated for treating conditions unrelated to audiovestibular symptoms such as obesity or addiction disorders. However, their use has raised safety concerns due to CNS or cardiac side effects (Christopoulou and Kiortsis, 2011; Klumpers et al., 2013) its role in treating the conditions described in this review is not defined Despite the abundance of data indicating the presence and participation of the EC system in the vestibular pathway, there are currently only a few publications (Schon et al., 1999; Pradeep et al., 2008) and just one clinical trial (Barchukov et al., 2015) cannabinoid antagonists may be advantageous during vestibular compensation related to the utilization of ultra-low doses of the active substance and limited information regarding their molecular properties Potential uses of CBs for other symptoms associated with vestibular disorders are described below and therefore the translational implications for humans are quite limited given the absence of studies in this regard CBD may theoretically be an otoprotective drug but no reports to date have demonstrated its efficacy in this regard It is unknown whether the use of cannabinoid antagonists may be effective for controlling tinnitus The present review shows that the EC system regulates audiovestibular function The few but significant references to the use of CB agonists/antagonists and MAGL/FAAH inhibitors that act on the EC system indicate that they may be effective for treating audiovestibular disorders The neuromodulatory effects of those compounds would act on symptoms as diverse as dizziness tinnitus or headache across different vestibular syndromes of central and peripheral origin (linked or not to neurological pathology) with sedative action and excitatory effects in others and with compensatory or protective functions as is typical in the case of CB antagonists A critical aspect concerning the use of drugs that act on the EC system is the absence and/or variability of doses used in all studies even in those studies performed in animal models This severely limits the application of EC system-targeting drugs and standardization in humans A further issue that requires discussion is the lack of pharmacogenetic profiles for most cannabinoid derivatives which affects all conditions that may benefit from their use an understanding of the pharmacogenetics of the cannabinoid derivatives dronabinol nabilone and cannabidiol is undoubtedly invaluable Genes related to the metabolism and/or to the mechanisms of action of these drugs contribute to problems with therapeutic efficacy and safety of those agents A pharmacogenomic strategy to optimize the use of drugs that interact with the EC system is required for successful whereas systemic drug administration allows for wider drug distribution to exert central and peripheral effects the effects of local delivery of these agents to the inner ear via more invasive direct approaches are unknown This application would be particularly appealing for those drugs with peripheral action or those with minimal CNS effects Made substantial contributions to conception and design of the review and interpretation adjusted and approved the final manuscript JG wants to acknowledge Adria Pijuan Monroy and Iria Rodriguez Lopez for being the inspiration to prepare this article The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation PubMed Abstract | CrossRef Full Text | Google Scholar Cannabinoid CB1 receptor expression and affinity in the rat 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2022;Published: 20 December 2022 Copyright © 2022 Guerra, Naidoo and Cacabelos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Joaquin Guerra, bmV1cm9vcmxAZXVyb2VzcGVzLmNvbQ== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Please check entered address and try again or go to homepage Troop 823 members (from left) Kaytlen Akau Jayda Wakilina and Aleah Yano after their first Girl Scouts meeting in March 2014 When most young ladies are lounging at the beach on the weekends Kyla Koerte and Alexis Cacabelos of Troop 823 are lending a helping hand in the community they’ve racked up more than 2,000 community service hours since joining the group in 2014 “You’re always wanting to give back,” says Akau Koerte didn’t consider volunteering a part of her repertoire I actually really enjoyed it,” she says “I don’t mind taking time out of my day to help people.” The generous trio has received recognition for their individual work through Girl Scouts was an honoree of the 2015 Prudential Spirit of Community Awards program because of her dedication to various service projects like working as a junior leader for the County of Kaua‘i’s Summer Enrichment Program won a Silver Award (the second-highest award achieved in Girl Scouts) for her mission to help feed the hungry collecting almost 400 pounds of food in 2016 was selected as the only representative from Hawai‘i to be part of a group of 21 girls from around the U.S that helped plan the 2017 National Convention for every G.I.R.L which stands for Girls Together Empowering and Mobilizing from the Girl Scouting movement the group provided input and feedback on areas like what activities discussion sessions and special events would comprise the three-day convention that took place earlier this month in Ohio “This has been the best experience I’ve ever been a part of,” says Koerte ambitious young ladies have been members of Troop 823 since they were in middle school They have since achieved the highest Girl Scout level of ambassador consists of keiki in grades K-12 that work their way through various levels — daisies They have journey books for each level that they work through as well as awards for lessons and projects completed where they learned self-defense techniques Another activity they have accomplished as a team is the Pink Pineapple Project It’s where all of the island’s Girl Scout troops get together to plant pineapples and participate in activities like pollinator garden planting and leadership games Each of these projects and lessons allow the girls to progress and become introduced to new thought-provoking skills and activities almost always with a focus on community service learn new things and shine,” says Caires who started the group three years ago because she has fond memories of being a Girl Scout as a child “Their growth has been tremendous.” Akau says that since becoming a member her growth has largely been related to confidence “It was a good opportunity to get out of my comfort zone,” she says Jayda Wakilina and Alexis Cacabelos help Hawai‘i Foodbank with its annual food drive at Safeway in Līhu‘e life as a Girl Scout has helped her become more assertive and open-minded “Being a part of Girl Scouts gives you a different view set on the world,” she says But it’s not always easy being a Girl Scout Koerte and Cacabelos have each been taunted since they were in middle school for being a part of the organization ‘Girl Scouts are for kids; it’s for babies,'” says Koerte Aleah Yano and Jayda Wakilina at the Kaua‘i Marathon county aid station in 2015 when they helped hand out cups of water to participants “And they all laugh about it,” agrees Akau ‘Watch what I’m going to do.'” Caires says that their struggles made them stronger and helped them become exemplary role models it’s a good thing,” says Caires about how being different can be beneficial Girl Scouts also helps prepare young ladies for the real world and how to manage various personalities as well as have enough initiative to work either independently or as a team “You think outside of the box because you work with such diverse people,” says Koerte “So when you go into a business or certain type of job you will know how to deal with certain situations and take a role that no one else is taking and how to step up and be the leader if you need to.” who have been friends since elementary school and knew each other through dance classes at Aloha Dance Studio what some of their favorite aspects about being part of the organization are they will tell you it’s the bonds they’ve formed with one another “It’s showed me how powerful teamwork is,” says Cacabelos “One person has their own set of goals but we’re always there to support one another so we’re always going to be there to help them reach it,” she says There are several Girl Scout troops across the island and some 5,000 members in the state. Troop 823 currently has 23 girls and is accepting new members, as well as volunteers. Email Caires at girlscoutstroop823@yahoo.com or visit girlscoutstroop823.com for more information Reporting for this story was supported by Journalismfund Europe under the Earth Investigations Programme GALICIA, Spain — The first sleepy rays of morning light are starting to illuminate the beach of Cambados a small Atlantic-facing town in the Spanish region of Galicia that’s famous for its shellfish and Albariño wine It’s a rainy morning in March and the mariscadoras — women shellfish pickers — are wading straight into the ocean armed with buckets and rubber boots for another day of work the tradition that has been passed down through generations of women and us too,” says Patricia Piñeiro between wind gusts and rain as she searches for clams big enough to harvest showing the measuring device from the local fishing authorities set to 4 centimeters (1.5 inches) which means she must return most of the clams she finds to the ocean “At this pace, the almeja fina [Ruditapes decussatus] and almeja babosa [Venerupis corrugata] will disappear,” says Maria José Cacabelos Domínguez a retired mariscadora who now organizes tours for people wanting to see the shellfish pickers in action an association of women in the fishing sector The lack of shellfish is now pushing many to take precarious informal jobs cleaning hotels or working in bars Besides sustaining livelihoods, shellfish play a vital role in regulating marine ecosystems they clean the water they live in by removing nitrogen making them an environmentally sustainable source of nutrient-dense protein A 2023 study from the local University of Vigo shows that the four main species of clams and cockles harvested in Galicia has proved to be more resilient to rising temperatures is vulnerable to prolonged periods of low salinity caused by heavy rains many of Galicia’s shellfish associations temporarily ceased activities to help stocks recover That includes the mariscadoras from the nearby town of Vilanova de Arousa They now receive a little more than 1,000 euros ($1,073) a month in government support who previously headed the town’s fishing guild the requirements are strict — those working a second job are often denied compensation — and payments are often delayed Rodriguez and her fellow mariscadoras of Illa de Arousa were among the last to quit working and they are now in the process of applying for monthly government support they are struggling to pick even 1 kilogram (2.2 pounds) of almeja japónica You can’t even pay your social security fees at the end of the month,” Rodriguez says “[A] lot of people have already left to go work on land because this is unsustainable.” Mass mortality events such as the one in December are likely to become more common as global warming disrupts rainfall patterns The problem is when that rain accumulates over a few days,” says Elsa Vázquez a University of Vigo zoologist who studies how changes in salinity and temperature affect the main shellfish species harvested in Rías Baixas the four productive estuaries in southwestern Galicia Torrential rainfall increases the amount of freshwater flowing from the river mouths into the estuaries, where the shellfish banks are located. Prolonged periods of low salinity affect bivalves’ ability to breathe Shellfish can close their valves during periods of low salinity to protect themselves but this uses up precious energy and weakens them Between October and November 2023, Galicia’s weather agency recorded more than 30 consecutive days of rainfall yielding more than 1,000 liters of rain per square meter (264 gallons per 10.7 square feet) — 127% more than normal salinity below 15 parts per thousand for several days causes mortality and this winter there were many days when salinity was as low as five parts per thousand,” Vázquez says The emptying of reservoirs during low tide by electricity companies also alters the estuaries’ delicate balance According to the Platform for the Defense of the Ría de Arousa the release of water should be timed to coincide with high tide to avoid freshwater inundating the shellfish banks a clear sign of global warming with significant implications for biodiversity Intertidal shellfish species bury themselves in the sand to keep cool but with heat waves becoming more intense the heat penetrates deeper which affects their growth and reproductive capacity Numerous shellfish pickers told Mongabay they want the Galician government to fund an in-depth study on the impacts of climate change to help inform potential solutions. Scientific models suggest 2060 could be a global tipping point for shellfish in many regions of the world with fisheries in Spain at high risk due to low species diversity and vulnerability to increased temperatures The development of clam hatcheries could be a solution While some commercial hatcheries exist for almeja japónica growing baby clams to be planted out on sandbanks more research is needed to cultivate almeja fina and babosa profitably She describes this as “the future of shellfishing” for its potential to establish enough reproducing adult shellfish to get stocks back to normal Another solution being explored is the real-time monitoring of salinity temperature and other variables in the shellfish banks This could help researchers create predictive models so mariscadoras could prepare for periods of low salinity and high temperatures adding that it would require dedicated government funding and support the mariscadoras are left with the few kilos of almeja japónica they manage to find Vales Martínez has worked as a mariscadora for 24 years just like her mother and grandmother before her “What’s really needed is to invest in the sea even if it means closing it for a year while stocks recover,” she says ”We need to address the root causes of the problem Can Spain keep the rising sea from washing away a critical delta? Carss, D. N., Brito, A. C., Chainho, P., Ciutat, A., de Montaudouin, X., Fernández Otero, R. M., … Jones, L. (2020). Ecosystem services provided by a non-cultured shellfish species: The common cockle Cerastoderma edule. Marine Environmental Research, 158, 104931. doi:10.1016/j.marenvres.2020.104931 Des, M., Fernández-Nóvoa, D., DeCastro, M., Gómez-Gesteira, J., Sousa, M., & Gómez-Gesteira, M. (2021). Modeling salinity drop in estuarine areas under extreme precipitation events within a context of climate change: Effect on bivalve mortality in Galician rias Baixas. Science of The Total Environment, 790, 148147. doi:10.1016/j.scitotenv.2021.148147 A global assessment of the vulnerability of shellfish aquaculture to climate change and ocean acidification FEEDBACK: Use this form to send a message to the editor of this post The “fortress conservation” model is under pressure in East Africa as protected areas become battlegrounds over history and global efforts to halt biodiversity loss Mongabay’s Special Issue goes beyond the region’s world-renowned safaris to examine how rural communities and governments are reckoning with conservation’s colonial origins and trying to forge a path forward […] Undisputed heavyweight champion George Foreman takes on Muhammad Ali a boxer with an impressive pedigree but who is now on the comeback trail Worry not, you’re still reading Decanter, not Sports Illustrated – but let’s draw a parallel. Bierzo has a millennia-long history of wine production but the region was somewhat forgotten for much of the 20th century the development of new projects and the arrival of new winemakers led to a resurgence and now Bierzo producers are making some of Spain’s best wines Is this small region – in a quiet corner of Spain far from major cities – ready to challenge its heavyweight counterparts among some of the world’s most famous wine regions Key point: Long-distance killing revolutionized warfare rifleman Thomas Plunkett of the British 95th Rifles was flat on his back in the snow outside of the Spanish town of Cacabelos Some might say that was no place for an Irishman but this was the waning days of the Battle of Cacabelos during the Peninsular Campaign of the Napoleonic Wars The French Général de Brigade Auguste-Marie-François Colbert was doing his best to lead French cavalry in a rearguard attack that could place the British Army at his mercy Plunkett wanted Colbert dead — and Colbert was more than 600 yards away Plunkett inserted his foot into the sling of his Baker .705-caliber rifle to stabilize the weapon tucked the butt of his rifle into his shoulder and took aim using only his skills and iron sights Then Plunkett took another shot that killed a second French officer who rode to Colbert’s aid soldiers in nearly every army of the Western world have carried some kind of rifle as their basic weapon It wasn’t the first rifled firearm placed in the hands of a foot soldier — the Germans and the Americans during the 18th century had used rifles with lethal effectiveness But less-accurate and rapidly loaded smoothbore muskets had dominated European battlefields for two centuries beforehand masters of the First Industrial Revolution had a weapon that could kill the enemy hundreds of yards away and be mass-produced The 19th century became the century of strategic warfare fought by riflemen who would adopt the tactics of “fire and maneuver.” When it came to this new field of battle an ordinary foot soldier caught in the open wasn’t just visible … he was dead Shooting solid projectiles at humans out of metal tubes using gunpowder for a propellant is nothing new and the English deployed artillery in a primitive form in 1346 at the pivotal Battle of Crécy Smoothbore “handgonnes” made their appearance in Europe during the last half of the 14th century — when they didn’t explode in the hands of their users at one time it was a weapon for elite forces only What makes a rifle what it is are grooves called “rifling” cut inside the barrel of the weapon that cause the bullet to spin That spin makes the ballistics of the weapon far more predictable muzzle-loading flintlock weapon of the Napoleonic Wars was the .705-caliber “Brown Bess” musket A good soldier could load and fire three shots per minute from a Brown Bess But the Brown Bess was effective only out to around 70 yards even a well-aimed shot would arrive a yard off target No wonder infantry tactics of the time relied on massed firepower delivered by infantrymen firing in volleys That’s because the musket ball fit loosely in the weapon’s barrel — it simply rattled off the wall of the tube when the weapon was fired and would even corkscrew its way downrange as it zipped toward its target But even early rifles were deadly accurate because the spinning bullet would travel along a flat you could aim a rifle and have a reasonable chance of hitting the target so-called Jäger rifles adapted from hunting weapons by the Germans in the hands of a skilled marksman could reliably hit quarry that were hundreds of yards away the muzzle-loading weapon was more difficult to load Black powder fouling and the rifling itself slowed the process down where the British learned some hard lessons about rifles in the hands skilled marksmen Timothy Murphy was one of 500 crack rifleman who had accompanied Gen John “Gentleman Johnny” Burgoyne and his invading British Army Murphy climbed a tree with his Kentucky rifle and took aim at Brig who was busy rallying the British troops in an effort push back the Americans’ regular forces Murphy took the shot even though Fraser was more than 300 yards away Murphy’s shot dropped Fraser to the ground — and the general died the next day The demoralized British retreated and the Americans won a victory that reverberated around the world convincing the French that the cause of independence was worth backing with money the British Army’s Board of Ordnance began a search for a reasonably priced soldier-proof rifle that could put that kind of accuracy in the hands of a small number of dedicated riflemen the army selected a design by Ezekiel Baker It was not a particularly innovative weapon sharing some of the features of the Jäger rifles from the previous century very well in the hands of one of the most famous rifle regiments in British history Fans of Bernard Cornwell’s Sharpe series of novels and the television series it inspired know of the 95th Rifles but even though Richard Sharpe’s exploits are fictional the historical importance of the regiment is dead accurate Whether you were a general or a drummer boy the 95th Rifles targeted and killed anyone responsible for command control and communication on the battlefield the British Army — as well as the rest of Europe and the Americas — began to realize riflemen were the future of warfare Add further technological changes such as reliable breech-loading mechanisms and less-expensive methods of manufacturing and soon every soldier — not just elite riflemen — was capable of long-distance killing on the battlefield contemporary soldiers should tip their helmets in honor of the Baker rifle and the troops who carried it Perhaps no other weapon in the last 200 years did more to shape a world of war fought with rifles This article first appeared several years ago. Image: Wikipedia Ending critical mineral dependence will require more than the recently announced deal with Ukraine the United States and Ukraine finally signed a rare earth mineral… ensconced in their mountains in northern Yemen French Rafale fighter jets are in global demand This highlights an increased defense spending across Europe and the Middle East Stay in the know with The National Interest newsletter © Copyright 2025 Center for the National Interest We use cookies to enhance your browsing experience We use cookies to help you navigate efficiently and perform certain functions You will find detailed information about all cookies under each consent category below The cookies that are categorised as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site We also use third-party cookies that help us analyse how you use this website and provide the content and advertisements that are relevant to you These cookies will only be stored in your browser with your prior consent You can choose to enable or disable some or all of these cookies but disabling some of them may affect your browsing experience Necessary cookies are required to enable the basic features of this site such as providing secure log-in or adjusting your consent preferences These cookies do not store any personally identifiable data Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms Analytical cookies are used to understand how visitors interact with the website These cookies help provide information on metrics such as the number of visitors Performance cookies are used to understand and analyse the key performance indexes of the website which helps in delivering a better user experience for the visitors Advertisement cookies are used to provide visitors with customised advertisements based on the pages you visited previously and to analyse the effectiveness of the ad campaigns Alzheimer’s disease (AD) is a major problem of health in developed countries and the most prevalent form of dementia representing the 6th cause of death in the U.S with and age-adjusted death rate of 25.4 per 100,000 metabolic and environmental factors are potentially involved in the pathogenesis of AD The age and sex-related syndromic profile of Alzheimer’s reflects a tetravalent phenotype: (i) a neuropathological component (classic hallmarks: senile plaques neuronal loss); (ii) a neurobehavioral component: cognitive deterioration functional decline; (iii) an age-related biological component (direct- hematological and metabolic phenotypes); and (iv) gender-related phenotypes the therapeutic intervention in dementia is polymodal in order to modify the expression of all these complex phenotypes AD patients present concomitant disorders including hypertension (20-30%) hypertriglyceridemia (20%); excess of urea (more than 80%) creatinine (6%) and uric acid (5%); alterations in transaminases (ASAT and ions (more than 10%); deficits of iron (5%) and vitamin B12 (4%); thyroid dysfunction (5-7%) and different modalities of cerebrovascular damage (more than 60%) are also frequent among patients with AD haematological and metabolic anomalies exhibit gender differences and may contribute to accelerate the dementia process The pharmacological treatment of these concomitant pathologies adds complexity and risks to the multifactorial therapeutic intervention in patients with dementia Of major relevance is the treatment of diabetes cerebrovascular and neuropsychiatric disorders The chronic treatment of these illnesses increases the risk of drug interactions and toxicity aggravating the clinical condition of the demented patient the incorporation of pharmacogenetics protocols into clinical practice is fundamental to minimise drug-drug interactions and ADRs and to optimise the global therapeutic outcome avoiding deleterious effects on mental function and cognition Major determinants of therapeutic outcome in AD include age- and sex-related factors Different categories of genes are potentially involved in the pharmacogenetics network responsible for drug efficacy and safety transporter and pleiotropic genes represent the major genetic determinants of response to treatment in AD By-products of these genes are integrated into transcriptomic proteomic and metabolic networks which are disrupted in AD and represent potential targets for therapeutic intervention AD patients may take 6-12 different drugs/day for the treatment of dementia-related symptoms including memory deterioration (conventional anti-dementia drugs (donepezil or for the treatment of concomitant pathologies (epilepsy cardiovascular and cerebrovascular disorders behavioural deterioration and psychomotor function can be severely altered by polypharmacy The principal causes of these iatrogenic effects are the inappropriate combination of drugs responsible for his/her pharmacogenomics outcome Pharmacogenomics accounts for 60 to 90% variability in pharmacokinetics and pharmacodynamics. The modest effect (and toxicity) of current Alzheimer’s disease drugs is in part due to their pharmacogenomics profile since over 70% of AD patients are deficient metabolisers CYP2C19 and CYP3A4/5 variants in the Iberian population yield 156 genotypes The most frequent haplotype is H3 (1/1-1/1-1/1-3/3) (20.87%) and only 17 haplotypes exhibit a frequency higher than 1% the most frequent haplotypes (more than 2%) are H55 (1/4-1/1-1/1-1/3)(8.41%) This indicates that about 80% of the population is deficient for the biotransformation of current drugs which are metabolised via CYP2D6-2C9-2C19-3A4 enzymes Most anti-dementia drugs are metabolised via CYP enzymes Alterations in cholesterol (CHO) metabolism are involved in AD pathogenesis and over 40% of AD patients are hypercholesterolemic The pharmacogenetics of cholesterol response to the hypolipemic compounds shows a great variability with a high response rate (RR) (78.95% responders and 21.04% non-responders) APOE-related basal CHO levels are significantly different with females showing higher CHO levels than males; however females and males responded similarly to the hypolipemic treatment The stratification of patients according to their APOE CETP and LPL genotypes shows no genotype-related differences at basal CHO levels except in the case of APOE carriers where the highest baseline levels of CHO are found in APOE-4/4 carriers and the lowest levels in APOE-2/2 carriers in addition to a clear age-related profile The construction of a pentagenic haplotype integrating all possible variants of the APOE+APOB+EPOC3+CETP+LPL genes identified 111 haplovariants with differential basal CHO levels About 75% of these haplotypes in the AD population have a frequency below 1% and only 4% of the haplotypes are present in more than 5% of AD patients The haplotypes most frequently found are H55 (33-CT-CC-AG-CC) (8.79%) H58 (33-CT-CC-GG-CC) and H37 (33-CC-CC-AG-CC)(7.07%) H110 (44-TT-CC-AG-CG)(0.11%) and H98 (34-TT-CC-AA-CG)(0.11%) show the highest CHO levels and the lowest levels correspond to haplotypes H26 (23-TT-CG-AG-CC)(0.11%) the CHO response to conventional lipid-lowering compounds is genotype-dependent and can It is obvious that a simple stratification of patients according to single genotypes is of poor value for a fine interpretation of pharmacogenetics results; however the integration of gene clusters associated with specific phenotypes yields informative haplotypes with potential utility in pharmacogenetics studies It is likely that thousands of genes are involved in CHO metabolism and probably not a single gene plays an absolute dominant role over the others; however some genes exert a powerful effect on other congeners associated with a specific pathogenic cascade (e.g APOE in AD) or a pharmacogenetics pathway (e.g APOE vs CYPs in AD treatment with donepezil) polypharmacy is imperative for the management of concomitant disorders; however drug interactions may constitute a severe complication with deleterious effects on brain function and quality of life the implementation of pharmacogenetics procedures can be of great utility for minimising drug adverse events and for optimising multifactorial therapeutics in complex disorders such as AD Pharmacogenomics of Alzheimer’s Disease: Genetic determinants of phenotypic variation and therapeutic outcome J Genomic Med Pharmacogenomics 2016; 1(2): 151-209 www.euroespes.com Please note: this is a commercial profile Save my name, email, and website in this browser for the next time I comment. Δdocument.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Open Access Government produces compelling and informative news, publications, eBooks, and academic research articles for the public and private sector looking at health, diseases & conditions, workplace, research & innovation, digital transformation, government policy, environment, agriculture, energy, transport and more. As a Crossref Sponsored Member we are able to connect your content with a global network of online scholarly research, currently over 20,000 other organizational members from 160 countries. Crossref drive metadata exchange and support nearly 2 billion monthly API queries, facilitating global research communication. Senior Weston Strum has been a strong runner for LMU. Strum does not want to run a bad race and lets "his actions do the talking". Weston Strum shares few words to describe his recipe for success, but he gives his teammates simple advice when solicited: “Just never have a bad race.” In his four years of running for LMU’s men’s cross-country and track team, Strum’s own bad races are few and far between. The senior cross-country and track runner is in the midst of his final season competing for LMU. He is considered by some to be the most successful male runner in LMU history. In cross-country, he’s earned All-WCC first team honors the past two years. In track, he owns school records in the 800-meter, 1,500m and 5,000m. “The fact of the matter is [that] when you put him in there, he just rises to the level of competition,” said Head Coach Scott Guerrero. “This guy is an enormous talent. Hands down, I don’t think I’ve ever seen anyone with that much talent.” Strum’s competitiveness can be rooted back all the way to his middle school PE class at Castillero Middle School in his hometown of San Jose, Calif. In sixth grade, Weston’s twin brother, Nathan, broke the school’s mile record in PE. A year later in seventh grade, Weston got the best of his brother and broke his brother's record. “I had first period PE, he had second period PE. In the first period, I break the school record in the mile,” Weston said. “It’s pretty cool because you get your name on the board outside of the cafeteria. I’m going to everyone and bragging and stuff, saying, ‘I got the school record.’ And then of course [my brother] beats my time in second period literally an hour later.” Nathan adds, "I used to be better than him, but towards the end of high school he started beating me.” In the pair’s last high school cross-country race in the CIF Division III Championships, Weston finished in 6th place with a time of 15:24, while Nathan finished in 17th place with a time of 15:46. The brothers continued running together throughout their time at Pioneer HS, until they went their separate ways in college. At UC Davis, Nathan focuses on middle distances and is his team’s top runner in the 800-meter run and 1,500m. The Strums have competed in several of the same meets, but have yet to compete head-to-head in an official collegiate race. The brothers are naturally busy as full-time student-athletes, but will occasionally text message each other bits and pieces of advice or updates on how their respective seasons are progressing. “They are so supportive of each other. They never fought,” said Strum’s mother Wendy. “They are just two boys with a mutual love for running.” Despite his success in high school and in college, Strum maintains a quiet confidence while avoiding complacency. “He’s not cocky, even though he’s had so much success,” Nathan said. “He's let his actions do the talking.” In early April, Strum finished ninth in the top heat of the 5,000m run at the Stanford Invitational with a time of 13:47.28. Strum’s time broke his previous school record of 13:57 set during his junior year, and also placed him at the No. 1 spot on the NCAA Division I West Region Outdoor Qualifying List. “13:47, I didn’t really picture ever running that fast,” Strum said. “It’s over my head.” The success may be a surprise to Strum, but his times have steadily improved since his freshman year in both cross-country and track. In cross-country he improved his freshman time of 25:04 to a 23:49 mark in the West Coast Conference (WCC) championships this past fall. In track, in his signature race, the 5,000m, his freshman time of 14:19.03 has dropped all the way down to 13:47.28. “Weston is a racer,” Guerrero said. “He’s evolved over time, and there’s a means to an end in practicing and working hard in workouts.” After four years of competitive racing, Strum has harnessed his raw talent and become a more experienced and strategic racer. "It’s developed over the years,” senior teammate Kevin Joerger said. "Freshman year, he would sit back and be conservative and at the end of the race he’d have a huge sprint, pass the whole field and take the win. Now that we’re seniors, I’ve seen him run a race in any way it could be run, whether it’s leading from the very beginning, or waiting until the end.” What’s the scoop on beating him in a race? "If I know Weston the way I know him, and know his weaknesses I’d probably just take a crowbar and hit him as hard as possible,” Guerrero jokingly remarked. Strum’s friends and family describe him as “quiet” and “introverted,” but insist his intense competitiveness is one of the main factors in his success as a runner. "He is competitive internally and has a desire to continually better himself,” Michael Strum, Weston’s father said. “He’s not competitive around other people. He’s actually very easygoing. He does what has to be done to help other people.” Outside of running, Strum excels in the classroom, earning First Team WCC All-Academic honors this past cross-country season. An accounting major, Strum has also tutored accounting for LMU’s Academic Resource Center since his sophomore year. "He works harder in school and running than really anyone else that I know,” Joerger said. Before Strum’s arrival to the Bluff, LMU’s men’s track and field and cross-country teams achieved limited success. In fact, Strum did not know about LMU until then-assistant coach Rick Weis sent him a Facebook message and told him the team was interested in him. “I just looked into [the school] and kept it on my list,” Strum said. "I could just could picture myself here. Everything kind of just worked out. It had the major I wanted and it was in a good area.” Strum chose LMU over UC Santa Barbara, among other schools. He has enjoyed the academic program the school has offered him, but is even more grateful for the community and his team. Strum lives off-campus with teammates, junior Michael Vorgitch and senior Douglas Petree. “Over the years, we’ve just gained this brotherhood with everybody,” said Strum. “It’s cool having all those people so close to me with all the same goals. I can trust them. I can talk to them about anything. That’s definitely the best part.” Last year, Strum and Joerger became the first-ever LMU males to qualify for the NCAA Division I West Regional meet. Strum qualified for the 5,000m race, but finished 13th overall, just one spot shy of earning a berth to the NCAA Division I 2013 Outdoor Track & Field Championships. This track season, Strum’s 5000m time is the tenth-best mark in the NCAA West Region, which will likely qualify him for the NCAA Track and Field Preliminary Round in Arkansas at the end of May. If Strum can finish in the top 12 in Arkansas, he will become the first-ever male LMU runner to qualify for the NCAA Championships. "We want to get an LMU jersey as deep into the season as we can,” Guerrero said. “When we can get those jerseys at regionals, nationals, people start to notice – it elevates our profile.” Does he feel any pressure to become LMU’s first-ever male qualifier for the championship meet? “I don’t feel pressure,” Strum remarked. "Surprisingly not.” The NCAA Division I West Regional meet in Fayetteville, Arkansas is set for the last weekend of May. Until then, Strum is focusing on his final set of classes at LMU while training through a couple of meets until regionals. Strum will graduate from LMU this May and then transfer to Northern Arizona University to pursue his Masters in Business Administration and use his last year of track eligibility. By achieving milestones such as competing in the NCAA Division I West Regional Championships in both cross-country and track, Strum has laid the foundation of success for future male runners at LMU. "He’s certainly going to go down as one of the best that’s ever gone through here,” Guerrero said. “It’s been a good run.” Email notifications are only sent once a day, and only if there are new matching items. View this post on Instagram A post shared by The Los Angeles Loyolan (@laloyolan) View this post on Instagram A post shared by The Bluff (@thebluff_lmu) Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Please disable your ad blocker, whitelist our site, or purchase a subscription dance instructor for the Aloha Dance Studio was busy adding bling to one of the costumes Monday “This catches the light,” Pelton said while the group gathered for its afternoon session “It gives it more reflections while the dancer is performing.” said 28 of its students will be traveling to the Jump National Workshop and Competition on Oahu this weekend at the Hawaii Convention Center (function(d,s,n){var js,fjs=d.getElementsByTagName(s)[0];js=d.createElement(s);js.className=n;js.src="//player.ex.co/player/bdc806f4-0fc1-40a1-aff0-a3d5239c169c";fjs.parentNode.insertBefore(js,fjs);}(document,"script","exco-player")); “This is the fifth year we’re taking the kids,” Dick said “The girls get to take in amazing workshop classes in ballet and contemporary dance from some of the top dance teachers in the country.” Aloha Dance Studio will also be competing with six solo performances on Friday Solo dance competitors include Malia Ebueng Saturday will have the Aloha Dance Studio competing in nine group events in the areas of contemporary Traveling members of the Mini Company include Annabelle Adversario Junior Company members include Ayzia Aceret-Coloma Senior Company members include Alexis Cacabelos Dick said traveling to the Jump event enhances the girls for the studio recital which will feature 120 students performing “Just Dance,” a celebration of 15 years for Aloha Dance Studio Wear a Lei was the theme of this year’s annual Kauai Museum Lei.. Members of the Waimea High School girls football team arrived home on Sunday from the 2025.. The 32nd AIDA World Championship kicked off today The spotlight was on the Dynamic Bifins (DYNB) event where freedivers swim underwater using bifins while holding their breath for the longest possible distance the newest addition to the freediving lineup since 2018 Magdalena Solich Talanda of Poland holds the AIDA World Record with an impressive 243 meters in the women’s category continues to lead the pack with a record of 290 meters Today marked a historic opening for the AIDA Pool World Championships: which included 114 athletes from 35 countries with support and enthusiasm from teams and online fans You can watch the highlights from today in the video below or on YouTube The vibrant and supportive atmosphere at the pool today set the tone for what promises to be an exciting four-day competition With numerous national and continental records already shattered we eagerly anticipate more groundbreaking performances as the week progresses Stay tuned for further updates and detailed coverage of the 32nd AIDA Pool World Championships here on DeeperBlue.com Photos and Videos courtesy of ICARUS Sports DeeperBlue.com is the World’s Largest Community dedicated to Freediving, Scuba Diving, Ocean Advocacy, and Diving Travel We’ve been dedicated to bringing you the freshest news and discussions from around the underwater world since 1996 Contact us: hello@deeperblue.com Volume 8 - 2021 | https://doi.org/10.3389/fmars.2021.649873 Marine forests ecosystems are typical of temperate rocky benthic areas These systems are formed by canopy-forming macroalgae (Laminariales and Fucales) of high ecological value that provide numerous ecosystem services These key species are also indicators of good environmental status marine forests have been threatened by different impacts of local and global origin putting their stability and survival in question marine forests have been replaced by “sea-urchins barrens.” We present a general overview of sea-urchins’ population status in the archipelagos of Azores focusing on their role in the maintenance of the so-called “alternate stable state.” After an in-depth evaluation of the different anthropogenic and environmental pressures we conclude that sea-urchins population explosion has been facilitated in the benthic habitats of Madeira and Canary Islands preventing the recovery of canopy-forming macroalgae assemblages and being one of the main drivers in maintaining a stable barren state Diadema africanum is the main barrens-forming species in Webbnesia where it reaches high densities and strongly impacts macroalgal assemblages such as the Selvagens Islands and other Marine Protected Areas from the Canary Islands africanum is up to 65% lower than in the nearby Madeira Island and macroalgal communities are preserved in good status This information is critical for marine environmental management highlighting the urgent need for implementation of appropriate control mechanisms and restoration actions headed to the conservation of marine forests in Macaronesian archipelagos Figure 1. Diagram illustrating the two-system rocky benthic bottoms: marine forests and sea-urchins barrens. Transition processes between states depending on fishing activities and habitat degradations impacts (modified from Sala et al., 1998) (Symbols courtesy of the Integration and Application Network, University of Maryland Center for Environmental Science (ian.umces.edu/symbols/) the present study aims to provide the first comprehensive compilation of the existing information on the potential threats affecting macroalgal forests of Azores focusing on the role of sea-urchins in the maintenance of the so-called “alternate stable state.” Evidence about the main anthropogenic pressures and other environmental factors involved in the sea-urchin population explosion historically detected are discussed and pondered across NE Atlantic archipelagos The Azorean archipelago (38.5°N,–28°E) is a group of nine volcanic islands with coasts formed by cliffs and rocky shores interspersed with sandy beaches (Borges, 2004). Waters surrounding the Azores are mesotrophic with sea surface temperature (SST) usually range between 15.5 and 23.2°C (Amorim et al., 2017; Sangil et al., 2018) it has not been detected in the rest of the Azorean archipelago Madeiran archipelago (32.4°N,–17°E) is formed by the islands of Madeira, Porto Santo, Desertas, and the distant southern Selvagens. The coastline in this archipelago is predominantly rocky, with a mix of platforms, boulders, and very few interspersed sandy-pebble beaches. The waters are oligotrophic, and SST typically ranges between 17.0 and 23.5°C (Schäfer et al., 2019) The Canary Islands (28.53°N,–15.74°E), located near the Northwest African Coast, are composed of seven islands that present high geological and topographic variability. The waters are oligotrophic, affected by a nutrient increase through the upwelling, and annual variation in SST ranging from 18.0 to 24.0°C (Valdazo et al., 2017; Sangil et al., 2018) Cabo Verde (14.91°N,–23.50°E) is an archipelago with an arid climate located in the mid-Atlantic Ocean (570 km off the west coast of Africa). SST usually ranges between 20 and 25°C with nutrient-rich waters supported by strong upwelling from the coast of Senegal and Mauritania (Freitas et al., 2019) with no reports of barrens originating from its grazing activities Long-term data on water turbidity and sediment load is necessary to evaluate the effects of these stressors across our study region and the particular consequences for the conservation of their coastal benthic communities the role of rising temperatures and marine heatwaves could be one of the main impacts for marine forests Rates of sea surface warming in NE Atlantic archipelagos based on 37 year of daily sea surface temperatures (SSTs; 1982–2018) from National Oceanic and Atmospheric Administration (NOAA) 1/4 arc-degree Daily Optimum Long-term effects need to be explored in depth for NE Atlantic archipelagos testing the combined effect of increased temperatures and acidification of coastal systems attention should focus on possible new massive mortality events as a consequence of meteorological processes as well as the consequences for the benthic macroalgal communities due to the sudden mortality of sea-urchins In this study we have chosen a series of factors and impacts available in the literature (Table 1) We assume that there are other important drivers in the development and maintenance of sea-urchin’s barrens that should be studied in future works in the NE Atlantic archipelago (e.g. Most of the information identified as evidenced in this work comes from studies developed in the most studied areas of the region the archipelago of the Canary Islands and the archipelago of Madeira it is necessary to expand the study of these drivers in the region in order to identify the main impacts and highlighting those that currently suppose correlative factors and hypotheses Interactions of discussed drivers and impacts over marine forests and sea-urchin barrens Recovery will definitely depend on first establishing important ecological protection rules the combination of multiple human pressures left the coastal system in a point of no return where the effectiveness of restoration actions will inevitably pass by the implementation of additional active management interventions in order to help the system to overcome the tipping point and reach a long-term re-establishment of the macroalgal forests AB-I: formal analysis and writing—original draft preparation All authors have read and agreed to the published version of the manuscript and IG were financially supported by pre- and post-doctoral grants in the framework of the 2015 ARDITI Grant Program Madeira 14-20 (Project M1420-09-5369-FSE-000002) This study was supported by the Portuguese government grant Fundo Azul under the Seaforest Portugal Project (FA_06_2017_067) this study also had the support of Fundação para a Ciência e Tecnologia (FCT) through the strategic project UID/MAR/04292/2020 granted to MARE UI&I We thank to Ashlie J. McIvor for the English language editing and review. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Alejandro Bernal-Ibáñez, YWxlamFuZHJvLmJlcm5hbEBtYXJlLWNlbnRyZS5wdA== The Loyolan continues its interviews with members of the LMU men's basketball team Redshirt senior Alex Osborne is in his fifth year with the Lions and is expected to be a contributor for the team after playing in all 34 games for the Lions Osborne averaged 5.3 points and 3.44 rebounds per game last year He is expected to push for a starting spot this season Kevin Cacabelos (KC): How do you feel entering the season I'm excited about how we're going to look when we're finally out there on Nov it's going to be faster than people expect It's going to be better than what people except I feel like I've learned a lot since I've been here I feel like I've gotten better and that I've come of age KC: What are some of the biggest lessons you've learned in your time here at LMU I worked out in a way I hadn't done before in the summer I tried to push myself more than I ever had before and it was good summer KC: What was different about the work out this summer I did way more CrossFits than I was definitely used to I really tried to work on the things I wasn't a good at I've been out for a month running and I still feel like I'm in the best shape of my life KC: Let's talk about personal expectations for you this year AO: I'm trying to have a career high in everything Every stat I want to have career highs in them KC: How would you describe it to a complete stranger on campus that knows nothing about haircuts AO: To people that know my name and know who I am "free in the front" and "free in the back." And that's just pretty much playing off of a mullet KC: Are you going to keep it for the season KC: What’s going through your mind when you’re playing post I’m trying to make the guy on me feel powerless against what I’m doing KC: Anthony Ireland called you out last year for not being tough in games Now – even though last year I was still coming off the bench there was so much uncertainty as to what coach is okay with me doing – I feel like a lot of it is just being coached This is what coach's plan of how basketball should be played I expect this team to compete in every game I expect this team to win – I've looked at the schedule I feel like we could win every one of those games KC: Coming off that WCC tournament run last season do you feel that momentum carrying over or is it just a brand new season I wouldn't say "carried over," I know we feel definitely positive and optimistic about what we can do when we're playing right But those games that we won they were just by one or two points and those are the same margin that we lost It's not like most of us got to deep into that We had to ride the ship and that's what this year is for KC: Which newcomer specifically stands out to you AO: I'm going to have to say [freshman forward] Gabe [Levin] KC: Anything else you'd like to add about yourself Follow @KevinCacabelos and @LoyolanSports on Twitter and like us on Facebook. Please disable your ad blocker, whitelist our site, or purchase a subscription Alex Rifkind (right) is LMU's first 2014 commitment verbally committed to the LMU men’s basketball team on Sunday afternoon The 6-foot-1 guard attends North Broward Preparatory School in Coconut Creek Rifkind is the first 2014 recruit to commit to the Lions I liked the campus and I liked the academics,” Rifkind said The LMU staff hosted Rifkind on an unofficial visit in June after they saw his highlight tape will likely be joining the team on a partial scholarship His family plans to move back with him to California when he starts at LMU Rifkind pinpointed his shooting ability as his best skill I also like to work the pick-and-roll action.” Rifkind mentioned a bevy of spot-up shooters “I also like watching Stephen Curry and Ray Allen.” the LMU coaches see him playing the shooting guard position and potentially moving to combo guard later in his career as a Lion I’m working on just being more aggressive on ball and getting stronger and faster,” Rifkind said The team graduates four seniors after the 2013-14 season Alex Rifkind 2012-13 season highlight tape: (Via: PSI Productions) Follow @LoyolanSports and @KevinCacabelos on Twitter and like us on Facebook. Please disable your ad blocker, whitelist our site, or purchase a subscription It is highly unlikely that James Parkinson (1755-1824) who first described the “paralysis agitans” in his ‘An Essay on the Shaking Palsy’ in 1817 (years later rebadged by Jean-Martin Charcot as Parkinson’s disease) could have imagined that the disorder that today bears his name would become the second most important neurodegenerative disorder in the elderly population With a prevalence ranging from 35.8 per 100,000 to 12,500 per 100,000 and annual incidence estimates ranging from 1.5 per 100,000 to 346 per 100,000 in different countries Parkinson’s disease represents today a major age-related problem of health Meta-analysis of the worldwide data indicates a rising prevalence of Parkinson’s disease with age (41 per 100,000 at 40-49 years; 107 at 50-59 years; 173 at 55-64 years; 428 at 60-69 years; 425 at 65-74 years; 1087 at 70-79 years; and 1903 per 100,000 at over age 80) also reflecting a characteristic distribution by geographic location (a prevalence of 1,601 per 100,000 in patients from North America and a prevalence of 646 per 100,000 in Asian patients Parkinson’s disease is more prevalent in males (1729 per 100,000 more than 65 years) than in females (1644 per 100,000) with a peak prevalence in the age group of greater than 90 years (4633 cases per 100,000) and a mean prevalence of 1680 per 100,000 in people older than 65 years of age Prevalence and incidence Male/Female ratios increase by 0.05 and 0.14 Incidence is similar in men and women under 50 years (M/F ratio <1.2) and over 1.6 times higher in men than women above 80 years PD coexists with dementia in over 25% of the cases and with depression in over 30% of the cases in some countries Associated with different potentially pathogenic risk factors (toxins Parkinson’s disease neuropathology is characterised by a selective loss of dopaminergic neurons in the substantia nigra pars compacta with widespread involvement of other brain structures and peripheral tissues Pioneers who contributed to understanding the pathology of Parkinson’s disease in the first quarter of the XX century were Frederick Lewy who identified neuronal cytoplasmic inclusions (Lewy bodies) in a variety of brain regions in 1912 who observed the loss of neurons in the substantia nigra in 1919 All these genes are under the influence of the epigenetic machinery (DNA methylation mRNAs) that regulate their expression in different tissues and may contribute to selective nigrostriatal dopaminergic neurodegeneration The introduction of L-DOPA in the 1960s represented a breakthrough in the treatment of Parkinson’s disease and it continues to be the most effective symptomatic therapy in Parkinsonian disorders Levodopa (L-DOPA) is the natural isomer of the amino acid D,L-dihydroxyphenylalanine which was isolated from the bean of Vicia faba in the early 1910s by Torquato Torquati Its chemical structure was defined by Markus Guggenheim in 1913; and in 1938 Peter Holtz discovered the enzyme L-dopadecarboxylase and which can be transformed into noradrenaline by the enzyme dopamine-β-hydroxylase Both catecholamines are important neurotransmitters involved in different higher activities of the central nervous system Other relevant scientists involved in the introduction of L-DOPA as a therapeutic option for Parkinson’s disease as elegantly described by Oleh Hornykiewicz In addition to dopamine precursors (L-DOPA) other symptomatic treatments for PD include dopamine agonists (amantadine monoamine oxidase (MAO) inhibitors (selegiline and catechol-O-methyltransferase (COMT) inhibitors (entacapone The initial complication of long-term L-DOPA therapy is the “wearing-off” phenomenon together with motor fluctuations and dyskinesia which develop during the use of both L-DOPA and dopamine agonists Diverse dopaminergic and nondopaminergic pharmacological approaches have been developed to manage such complications glutamatergic N-methyl-d-aspartate (NMDA) antagonists and glutamate mGluR5 modulators (mavoglurant) antihistamines and cholinesterase inhibitors also contributes to severe complications associated with the anticholinergic burden in Parkinson’s disease gastrointestinal complications (constipation neuroendocrine changes and psychiatric disorders are frequent in Parkinsonian patients chronically treated with conventional antiparkinsonian drugs The onset of these complications is also influenced by the genomic background of the patients and the efficacy and safety of the drugs currently consumed by those who suffer a Parkinsonian disorder is highly dependent on their pharmacogenomics profile Genes involved in the pharmacogenetics network include: pathogenic and all these genes are also under the influence of potential epigenetic aberrations In recent years novel evidence has demonstrated the impact of pharmacogenetics on the efficacy and safety of most antiparkinsonian drugs and PARK2 genes are pathogenic genes potentially involved in its effects and OPRM1 genes are mechanistic genes whose products influence L-DOPA efficacy and safety L-DOPA is a substrate of enzymes encoded by the COMT and UGT1A9 genes responsible for its metabolism SLC6A3 is the major transporter of L-DOPA; and ACE ACHE and APOE are pleiotropic players in L-DOPA effects ADORA2A SNPs and HOMER1 variants may be associated with L-DOPA-induced dyskinesia and psychotic symptoms TaqIA and rs2734849 polymorphisms at the DRD2/ANKK1 gene region might also be associated with L-DOPA-induced motor dysfunction; and SLC6A3 is a genetic modifier of the treatment response to L-DOPA in Parkinson’s disease Since the “wearing-off” phenomenon and additional complications related to the chronic use of antiparkinsonian drugs represent a major concern for patients and the medical community some voices claim for changes in the conceptualisation of Parkinson’s disease and its treatment It is obvious that the growing prevalence and incidence of Parkinson’s disease for the past 50 years must be associated with environmental factors (toxic vascular) which demand better epidemiological scrutiny and consequent preventive programs to halt disease progression If this is assumed by health authorities and the scientific community then new challenges should be raised in relation to the pathogenesis and treatment of Parkinson’s disease if we do not want to experience a situation similar to that of schizophrenia (another disease related to a cerebral dopaminergic dysregulation) in which the excess of antipsychotics/neuroleptics leads to a disabling extrapyramidal syndrome after years of neuroleptic treatment it is imperative to characterise biomarkers for the pre-symptomatic identification of the population at risk of suffering Parkinson’s disease as well as alternative therapeutics devoid of the long-term complications posed by conventional antiparkinsonian drugs Some attempts have been made with novel compounds in recent times The revival of some classic natural products has also been proposed; and new applications have been submitted to the European Patent Office in this regard with selective dopaminergic neuroprotectants to prevent neurodegeneration Modern Neuroscience must embrace the idea that most brain disorders require more neuroprotection and fewer symptomatic repressors the history of Neuropsychopharmacology is a history of chemical symptomatic repression with delayed consequences for patients and society in terms of chronic disability Professor and Chairman of Genomic Medicine www.euroespes.com and website in this browser for the next time I comment Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Open Access Government produces compelling and informative news and academic research articles for the public and private sector looking at health As a Crossref Sponsored Member we are able to connect your content with a global network of online scholarly research currently over 20,000 other organizational members from 160 countries Crossref drive metadata exchange and support nearly 2 billion monthly API queries facilitating global research communication By Associated Press HILO >> Heading into Papaaloa from Hilo on Route 19 the only hint that there is anything new at Mile 24 is a discreet sign set low to the ground featuring an orange-toned drawing of a building and indicating the driver should take the next right turn On making the turn and driving a short way over a bridge and past the Papaaloa Hongwanji Mission the visitor is greeted by the real-life version of that building: the Papaaloa Country Store and Cafe People bustle up the steps and to the counter of the back kitchen where they order pork and eggplant plate lunches jokingly greet the head chef and store co-owner and browse the shelves of the general store area One woman says she drives from Kohala just to come here Not too bad for a business that’s only been open since mid-June Even though the Papaaloa Country Store and Cafe is new It’s a holdover from the plantation era part of a hub that once included a bank and a sugar mill and is old enough to predate its own county records people found receipts in the basement from 1910 The building had always served as a general store when the previous owners put it up for sale and closed the business So when the store’s new owners — Blyth is joined by his brother and his sister-in-law Sol and Kristina Ammon — first began restoring the historic space two and a half years ago they were intent on preserving more than just its structure "It’s also cultural preservation," said Kristina Ammon it’s important people feel like they’re included." (Her parents own the building itself; Blyth and the Ammons own the business.) They got a sense for how much the establishment meant to the community during the renovation process as they navigated the county permit system while cleaning floors They debated keeping an old butcher track on the ceiling to give a sense for the old store (the rusty equipment ultimately came down) and added a long wheelchair ramp to the front of the store which blends seamlessly into the overall façade of the building people stopped by to ask when they would be opening There was no grand announcement for when it would happen "We got really flooded the first day." "People have come in who are in their 80s who used to come in as kids," he said One woman came in to tell the staff how glad she was that she could come get snacks for her daughter on the way to sports practice — just like she’d done with her own mother And one Papaaloa resident returned to her old role: Alvira Cacabelos worked at the store in its old incarnation "I’m happy to be back," Cacabelos said "This place is spiritual; there’s plenty of history." known to many in Hilo for her old business Gehweiler prepares everything from hoagie rolls to cakes to cream puffs The team sees the entire project as fitting in with the greater revival of the Hamakua coast as small-scale farming moves in where plantation monoculture once dominated and intend for the farm’s products to "feed the store" within the next couple of years But they also want to support producers in the area to offer as much locally grown food as possible while helping the community grow and thrive They will begin accepting Electronic Benefit Transfers in the next month and are working with the public charter school to offer internships the next step is to finish preparations on a dining room area where people will be able to have ocean views while they eat "We’re really just getting started," he said 500 Ala Moana Blvd. #2-200Honolulu, HI 96813(808) 529-4747 Here are a few things I learned along the way… This is one of the rare times you won't be able to rely on technology Internet and phone signals are sparse on the Camino; and unless you like the experience of not knowing how far you'll walk or where you'll sleep that night James in Your Backpack gave a great breakdown of places to stay and recommended mileage to cover each day are integral parts of the Camino experience and gave ourselves time to enjoy the towns along the way and by some we were dismissed as “not authentic pilgrims” (as travelers on the Camino are called) but it gave us the freedom to walk at own pace and know we had a place to sleep a little tip you might not read in the guidebook: We discovered that if you walked a little farther or stopped earlier than suggested in the books you might find smaller crowds and more agreeable hotels Some of our favorite towns for overnight stays were Cacabelos Final destination: the Cathedral of Santiago de Compostela To get your official certificate (called ‘Compostela’) from the Pilgrim's Office in Santiago de Compostela, you have to cover at least the final 100 kilometers (62 miles) of the Way on foot or horseback, and the final 200 kilometers (124 miles) on bicycle. The moment you arrive at the 100km-to-go mark, tourism groups and pilgrims start flooding the road. The experience is simply not the same. Start before the mark and take advantage of the solitude. The extra distance is worth every step. up-to-the-minute voice in all things travel Condé Nast Traveler is the global citizen’s bible and muse We understand that time is the greatest luxury which is why Condé Nast Traveler mines its network of experts and influencers so that you never waste a meal or a hotel stay wherever you are in the world Miss Mokihana Teen USA 17-18; Kaira Kaʻaihue Miss Kauaʻi Teen USA 17-18; Tiffany Sagucio Miss Garden Isle Teen USA 2018; Kiʻilani Arruda Miss Garden Isle Teen USA 17-18; and Megan Ann Souza Kauai’s newest royalty were crowned at the the Hilton Garden Inn on Aug Manuel and Arruda both won the evening gown phases in their division while Manuel won the Swimsuit phases and Arruda won the Active Wear Phase Manuel also won the Photogenic Award chosen by pageant photographer Brayden Suliven and the Popularity Award for selling the most tickets to the pageant Akau received the “Social Media Fan Favorite” Award receiving 869 combined likes on Facebook and Instagram on her official headshot Teen contestants included Alexis Cacabelos and Brandie Aguinaldo who sold the most program book ads winning the Hospitality Award; Dawn Serapio who won the People’s Choice Award; and Tiffany Sagucio received the Congeniality Award All contestants received a scholarship from Argosy University while the teen winners received $7,000 and the miss winners received $10,000 Winners will compete in the Miss Hawaii USA and Miss Hawaii Teen USA state pageant on Nov 18 at the Hawaii Convention Center with hopes of advancing to Miss USA/Miss Universe or Miss Teen USA The Miss Universe Organization is the largest pageant organization in the word also having the largest fan base of any pageant in the world making it a perfect place for young women to have their voices heard while continuing to reach their personal and professional goals The Miss Universe Organization empowers women to develop the confidence they need to achieve their personal best A confident woman has the power to make real change starting in her local community with the potential to reach a global audience The Hawaii Association of Sand Sculptors hosted its fourth annual Sand Festival Aug Amateur and professional sand sculptors from around the world were invited to spend the day creating visions in sand families and teams of friends ranged from castles and cupcakes to smoking dragons and yellow submarines The most attractive works by individuals and teams received prizes Coleman Scott will face the winner of the contest between Germany's Tim Schleicher and Japan's Kenichi Yumoto for the bronze medal The bronze medal match will take place at 12:45 p.m The United States was dominant in the 2012 London Olympics With the final events of the 2012 Summer Olympics wrapping up on Sunday it is time to review the final medal count for the games was able to outlast Spain in the men's basketball Gold Medal Game London 2012 concludes on Sunday with the Closing Ceremony The United States clinched the medal count for the fifth straight Summer Games on Saturday night Usain Bolt and Team USA women's basketball team were the stars of London's Saturday Olympic action took home a bronze medal after beating Japan's Kenichi Yumoto in the men's freestyle 60kg (132 pounds) third place match on Saturday night in London Team USA now leads China by 10 medals after a big day in track and field women's volleyball team advances to the gold medal match to face either Brazil or Japan for the gold medal Hopewell High School graduate Christa Harmotto is a middle blocker for the team Team USA now trails China by just one in the overall medal count The American women's soccer team won 4-3 over the Canadians to advance to the finals at the 2012 London Olympics The 2012 London Olympics continue on Monday Pittsburgh native Cassidy Krug competes in the final of the 3m Springboard Cassidy Krug and Christina Loukas are chasing five-time medal winner Wu Mingxia of China who sits well atop the field after a top qualifying score of 394.400 The United States of America leads both in overall medal count and gold medal count through Saturday's events at the 2012 Olympic Games a global leader in outsourced customer and citizen experience management kicked off its celebration of 27 strong years in the industry through the Spark 2023 Grand Celebration held at the SMX Convention Center in Pasay City recently The event gathered leaders and employees from various sites and accounts to celebrate the company’s history of successes and milestones and to reenergize the whole workforce for the next years to come Hosts Sean Kyle and Karla Aguas led the celebration while Spongecola and DJs Jimmy Nocon and Siangyoo provided entertainment for the whole TP family Employees and leaders alike came in their best sparkly outfits to match the theme of the event Teleperformance Philippines also rewarded its most talented employees proving how much the company values its people by allowing them to express themselves and by providing them avenues to enrich their passions and talents outside work The Spark Grand Celebration was not just limited to Metro Manila as celebrations were also held separately for their Luzon Teleperformance Philippines recognizes the importance of its people in its achievements Occasions like the Spark Grand Celebration provide the perfect opportunity to look back and appreciate the contributions and skills of their employees while also strengthening their bond as a team Vice President for Human Resources and Communications & Marketing Rachel Cacabelos expressed her hopes for a stronger year for Teleperformance She underscored that Spark was a moment of enjoyment but also “an opportunity to reflect on our past successes and use that energy and momentum to propel us forward.” “As Teleperformance continues to have its culture of excellence recognized Teleperformance has become one of the most preferred offshore contact center operations in the country and a valuable player in the Philippine economy Teleperformance was awarded the fifth Best Workplace in the Philippines by Great Place to Work® Philippines in its first in-person gala since the pandemic This second consecutive win recognized TP’s success in transcending the standards of best work practices through impact sourcing and policies ensuring diversity Teleperformance remains committed to being a trusted partner to all its stakeholders putting people at the heart of business transformation and customer experience As pandemic restrictions are being eased out Teleperformance strengthens its relations with the business and economic sectors as well as the academe and other institutions promoting environmental For more information about Teleperformance Philippines, visit www.teleperformance.ph. Credit: On AssignmentIf you think of people who fish most of us will probably imagine fishermen it's the women who dominate a particular trade these women have passed down traditional skills from generation to generation mothers and daughters have all grown up with this trade touching every aspect of their lives to meet some of the women and hear about their pride in this work which they fiercely protect for the next generation Many of their methods are unchanged in hundreds of years but what is changing is the climate around them Shell fish stocks have been hit hard by extreme weather events including heatwaves and heavy rainfall Data from the Galician government shows numbers at the end of 2023 were just 15 percent of what they were the year before with all four of the main species of shell fish harvested in the area now struggling to recover María José Cacabelos who is the president of Guimatur "Salinity dropped and a lot of shellfish died," she said but added that jobs in contact with nature are vulnerable to the weather The mariscadoras have a bond that runs through their veins with friendships built on the muddy sand at low tide where they gather shellfish The skill and value of the work mustn't be underestimated their income supported that of the men in the family paying for the day to day costs of running a household while the wages from the fishermen covered bigger expenses the shell-fisherwomen provide what is the only income for families when the weather is too bad to go out to sea The job continues to appeal to younger women who are juggling modern life Working around the tides and regulations to protect fish stocks means each "shift" is usually around four hours long allows time to manage other responsibilities at home collecting shellfish would help pay for a night out Now she fits the job around looking after her son having witnessed over decades the changes in the climate and also the environmental threat from other industries to their profession Recently some of the women have been involved in demonstrations against a pulp company who plan to build a new factory in Galicia Victoria swears she will fight until it's "kicked out" and she will "fight like a champion." I had the strong impression that this way of life won't be stamped out easily determination and passion could very well save and protect it as losing it would mean more than just a loss of income it would be the loss of their sense of identity You can watch On Assignment at 11.30pm July 30 or catch up later on ITVX Want a quick and expert briefing on the biggest news stories Listen to our latest podcasts to find out What You Need To Know… SB Nation Seattle's Kevin Cacabelos ranks the top 25 high school basketball players in the state of Washington Who is the number one high school basketball player in the state of Washington other websites and my own observations to rank the top 25 high school basketball players in the state of Washington This year, seven of last year's top ten players have graduated, including the former No. 1 player, Kansas-bound Anrio Adams. Bothell's Zach Lavine moves into the top slot after an impressive junior year campaign and a commitment to the UCLA Bruins Rankings are based on this criteria: 1) Potential to play and perform at the Division One level of college basketball2) Current performance at the high school level 6'3": The smoothest scorer in the state has some deficiencies in his game but because of his unlimited range and athleticism he's the best player in the state of Washington Lavine will need to be more aggressive in attacking the defenses by penetrating and relying less on his shooting ability it is just a matter of him taking more initiative 6'1": Rorie is a lightning quick point guard who can get to the rim and finish with grace He has good balance and body control and excels in transition because of these traits 6'6": Everyone knows he can penetrate and score at will off the dribble but not many people notice how good Fenner is defensively He has quick hands to force steals and nice leaping ability and timing to block shots Fenner will have to improve his slow-release on his jump shot to gain more interest from more high-end division one schools 6'6": Lexing is not the type of player who is going to take over games by himself but his length and athleticism project him as an effective player at the next level He shows solid ability to get to the rim and finish in transition but will need to improve his shooting touch 5. Brett Bailey (Sr.)- University 6'6": Watching him at the state tournament this past March was a revelation Bailey might have the prettiest jump shot in the state Bailey can score off the dribble and is crafty at using pivots to draw contact to get to the free-throw line 5'9": On the biggest stage at the 3A State Championship Marquis Davis played the best out of a collection of the state's top talent The elevation and form of his jump shot is eerily similar to Rainier Beach-alum Nate Robinson While his level athleticism certainly doesn't match Robinson's Davis' quickness and perimeter offensive skills are unmatched by anyone at the state at his position 6'5": Haymond did everything right in his junior year at Garfield Not only did he show an ability to score from the perimeter but he showed an ability to post-up smaller players rebound and make the right pass to involve his teammates 6'8": Meikle is a lanky and versatile forward who is comfortable facing up and taking his man off the dribble He'll be a solid role player for the Zags at the next level but he will need to add strength to his frame to become a consistent contributor but he has a decent range on his shot and he can hold his own against stronger players range that extends to the three-point line and above average shot-blocking ability His transfer to Bothell makes them a definite state contender in 4A 6'7": Berger is a long forward with exceptional scoring ability He opened some eyes on the national recruiting scene this summer and will definitely surprise fans and observers this upcoming high school season Next 15 in (in alphabetical order): Patrick Ball (Franklin), Brayon Blake (Federal Way), Marcus Chambers (Foss), David Crisp (Clover Park), Elijah Foster (Rainier Beach), Jordan Johnson (Lakes) For all the latest recruiting news on local basketball prospects, follow @KevinCacabelos on Twitter