This is the first tranche of a Series A Round for IBI Ag's novel bioinsecticide platform Consensus Business Group ("CBG") and a grant from the Israel Innovation Authority —underscores the strategic importance of IBI Ag's innovative biological and naturally-inspired solutions in the global agricultural sector to assist farmers in producing more food by protecting their crops and the global food chain IBI Ag has developed technology that leverages single domain antibodies to produce highly effective crop protection solutions with a low ecological footprint This technology—adapted from pharma and modified to fit the agricultural market—provides novel modes of action and represents a revolutionary new approach for protecting crops from insects The products under development target a broad spectrum of insects both sucking and chewing insects with minimal impact on non-targeted organisms The company is targeting high value crops to start and will follow with row crop solutions "We are thrilled to have the support of our existing and new investors led by Corteva through their Corteva Catalyst platform," said Arnon Heyman "This investment will help us to accelerate the development of our single domain antibody technology providing farmers with sustainable and effective crop protection solutions We believe our single domain antibody technology is a game changer for driving agricultural productivity while preserving the environment and the investment announced today is a significant step towards delivering this innovation to farmers across the globe." "We see considerable potential for IBI Ag's bioinsecticides to be a smart solution for farmers to tackle devastating insects while minimizing environmental impacts," said Tom Greene "Our investment aligns with our continued drive to put cutting-edge innovation into the hands of farmers and reflects our strategic focus on accelerating development of next generation biological and naturally inspired solutions." About IBI AgIBI-Ag is a pioneer in the Agri-biotech industry committed to developing innovative and sustainable solutions for crop protection The company's proprietary technology platform utilizes nano-bodies—a type of antibody—to create effective and safe biological insect control solutions This breakthrough technology has the potential to protect the global food chain by helping farmers protect their crops with a lower ecological footprint and to transform the agricultural industry by offering an environmentally friendly and cost-effective alternative to chemical pesticides IBI Ag was established by The Trendlines Group together with the founders Amir Ayali PhD and Rony Oren Benaroya PhD and with the support of the Israel Innovation Authority Media Contacts:IBI Ag: Arnon Heyman, CEO IBI Ag, e-mail: [email protected] Photo - https://mma.prnewswire.com/media/2619674/IBI_Ag_team.jpg Do not sell or share my personal information: 2025Men's Golfvs NCAA RegionalsLoad MoreRecent ResultsCompleted Event: Softball at No Featuring the Runnin’ Utes: Ibi Traore1/11/2025 10:58 AM | Men's Basketball Traore is one of two true freshmen and one of six international players on this year's Runnin' Utes squad 2023-24 Report The IBI Utilization Rate increased to 85.3% in January after remaining below the normal expansionary range in Q4 Strong consumption continued to outpace growth in inventories pulling down utilization during the holidays reflected by a utilization rate below 85.5% and sublease availabilities above 1%.iii Customers report they are growing into existing capacity supported by January increases in both the Utilization Rate and the IBI Utilization Index the IBI Activity Index reflected elevated throughput averaging an expansionary reading of 59 during 2024 and inching up to nearly 60 in January industrial real estate leasing activity accelerated after the presidential election but early signs of demand diversification surfaced across industries The shift in market conditions is fueled by a marked change in the supply backdrop New deliveries fell by 38% year-over-year in 2024iii while a sizeable gap between replacement cost rents and market rents produced a challenging environment for speculative development New building starts fell nearly 40% year-over-year in 2024.iv As a result completions are poised to fall by another 35% in 2025 allowing vacancy rates to decrease later in the year as new supply falls short of new demand.iii Rents are expected to rise later in 2025 with signs of growth already emerging in select markets Rent growth varied widely by market in 2024 with Southern California again recording the most pronounced decreases rents remained largely resilient with several markets posting positive rent growth heading into 2025 The industrial real estate market continues to progress through a mini-cycle with vacancy rates peaking as occupiers move cautiously to expand supply chain networks Proposals and leasing activity reflect early signs of a post-election shift as greater certainty prompts decision-making This momentum plays into our expectations for a 20% annual increase in net absorption for 2025 with velocity increasing as the year progresses Vacancy rates should decline alongside a 35% reduction in new completions.iii The market remains favorable to occupiers in the near term before conditions tighten through the year.  The Prologis Industrial Business Indicator (IBI) is derived from a survey of Prologis customers on their warehouse activity and utilization Respondents classify activity as “Weaker,” “Same,” or “Stronger,” relative to the prior month and these answers are combined into a diffusion index ranging from 0 to 1 respondents classify space utilization as “More,” “Same,” or “Less,” relative to the prior month and these answers are combined into a diffusion index ranging from 0 to 1 The utilization rate is reported as an average percentage reflecting how fully respondents are using their available warehouse space.  Prologis Research.iv Prologis Research.  This material should not be construed as an offer to sell or the solicitation of an offer to buy any security We are not soliciting any action based on this material It is for the general information of customers of Prologis on public information that we consider reliable but we do not represent that it is accurate or complete No representation is given with respect to the accuracy or completeness of the information herein Opinions expressed are our current opinions as of the date appearing on this report only Prologis disclaims any and all liability relating to this report any express or implied representations or warranties for statements or errors contained in projections or predictions given in this report are intended to be forward-looking statements Although we believe that the expectations in such forward-looking statements are reasonable we can give no assurance that any forward-looking statements will prove to be correct Such estimates are subject to actual known and unknown risks uncertainties and other factors that could cause actual results to differ materially from those projected These forward-looking statements speak only as of the date of this report We expressly disclaim any obligation or undertaking to update or revise any forward-looking statement contained herein to reflect any change in our expectations or any change in circumstances upon which such statement is based No part of this material may be (i) copied photocopied or duplicated in any form by any means or (ii) redistributed without the prior written consent of Prologis Prologis’ Research department studies fundamental and investment trends and Prologis’ customers’ needs to assist in identifying opportunities and avoiding risk across four continents The team contributes to investment decisions and long-term strategic initiatives in addition to publishing white papers and other research reports Prologis publishes research on the market dynamics impacting Prologis’ customers’ businesses including global supply chain issues and developments in the logistics and real estate industries Prologis’ dedicated research team works collaboratively with all company departments to help guide Prologis’ market entry is the global leader in logistics real estate with a focus on high-barrier on a wholly-owned basis or through co-investment ventures properties and development projects expected to total approximately 1.3 billion square feet (120 million square meters) in 20 countries Prologis leases modern logistics facilities to a diverse base of approximately 6,500 customers principally across two major categories: business-to-business and retail/online fulfillment Every connection starts with a conversation We chat with award-winning, New York Times bestselling author Ibi Zoboi about S(K)in which is a novel in verse based on Caribbean folklore—about the power of inherited magic and the price we must pay to live the life we yearn for PLUS we have an excerpt to share with you at the end of the interview I’m Ibi Zoboi and write for children and teens but my first published Young Adult fantasy novel (in verse) I exaggerated the littlest things just to make it more interesting and this when I first began to try my hand at poetry but there’s no room for the imagination and metaphors in journalism Readers can expect the five words I listed above I’m from the Caribbean where there is a huge magical world of carnival characters I’ve always wanted to infuse Caribbean folklore into my stories I loved examining the girls’ internal conflicts I had to balance world-building with an unconventional magic system and the emotional journey of two girls who are coming to terms with their powers I thought of all the ways I could complicate the story See alsoQ&A: C.L. Clark, Author of ‘The Unbroken’ The most challenging thing is the poetry aspect I had to think deeply about how the words on the page also tell a story The shape of the poems and how they mirror and merge acts as a subplot I’m looking forward to Maika and Maritza Moulite’s The Summer I Ate the Rich beautifully designed and comes with everything you need to engage your visitors and increase conversions The Magazine of the Science Fiction and Fantasy Field IBI AANU ZOBOI was born was born Pascale Philantrope in Port-au-Prince and now lives in New Jersey with her husband and three children; she legally changed her name after marriage She also attended a Voices of Our Nations Arts Foundation workshop in 2011 and earned her MFA in Writing for Children and Young Adults at Vermont College of Fine Arts in 2014 She has extensive experience as an educator running community-based programs for teen girls in Brooklyn NY and Haiti and working as a writer-in-residence and teaching artist in New York City public schools Her debut YA novel American Street appeared in 2017 and was a National Book Award finalist a contemporary remix of Jane Austen’s Pride & Prejudice; and Coretta Scott King Author Award winner Nigeria Jones (2023) Her middle-grade books include novel My Life as an Ice-Cream Sandwich (2019) and non-fiction volume Star Child: A Biographical Constellation of Octavia Estelle Butler (2022) Picture book The People Remember is illustrated by Loveis Wise (2021) She co-wrote Yoto Carnegie Medal finalist Punching the Air (2020) with Yusef Salaam and edited Black Enough: Stories of Being Young & Black in America (2019) She also wrote Black Panther tie-in novel Okoye to the People (2022) for Marvel Nalo Hopkinson first started writing about soucouyant in Skin Folk but that wasn’t the first time I heard about the soucouyant who looks like an old woman in the day but turns into a fireball at night it’s a catchall term for any sort of shapeshifter Edwidge Danticat has written about the lougawou more in terms of a person who’s accused of being one In wanting to write speculative fiction based on Haitian folklore and mythology But I first wrote about Old Hag in Sheree Thomas’s anthol­ogy Dark Matter: Reading the Bones in 2004 It’s one of those books that I think people should still be talking about because it was the first of its kind Du Bois and an original story by Octavia Butler Thomas brought all these people together to say ‘We write science fic­tion and fantasy.’ I was in the sequel with a story called ‘Old Flesh Song’ I have revisited that figure over and over again in different short stories until I started writing about it in novel form when I did my MFA program “The book was first called Skin Sisters and then turned into (S)Kin The novel was my graduate thesis for my MFA program over ten years ago I always knew I would come back to the story I knew I’d have to rewrite this whole thing but I wanted try to pare it down to its bones The poetry worked because I’m able to pull from Caribbean storytelling and vernacular I decided to try a fan­tasy novel in verse and see how it works to play with rhythm and musicality and metaphors with this story about two girls who have inherited a certain kind of magic but I have been explor­ing this aspect of Haitian folklore and Caribbean folklore for my entire writing career “The challenges between writing a novel in prose or in verse are vastly dif­ferent You need to have the mind and the soul to be able to pull that off I’m always thinking symbolically and making connections to things that are seemingly disconnected Haitian Creole is very musical – it can sound harsh and it is the most sing-songy language; there’s music to it You have to hear the music in the language and you have to take the English words and make them musical “What worked for me is that I had lived in this world for a very long time but I have been imagin­ing how a girl or woman will physically shift out of her skin to become a ball of flame but to do it in poetry is much more powerful I want to believe that I got the imagery across and I got the emotion across You have to pull on the metaphor in writing a novel in verse It’s been done before in different ways – read Edgar Allan Poe poetry Strange Horizons used to publish science fiction poetry “The character Marisol has newly arrived with her mother from the islands and I don’t name the island that she comes from because what people sometimes forget is that migrants can travel from island to island There are Haitians in the surrounding islands There are people from other islands in Haiti doing business Usually the migration happens within the islands and what you know about her is that she’s dark-skinned with short hair And there is something powerful about her dark skin that allows her to be that much more powerful as a soucouyant and two new twins who are her half siblings She knows her mother is a Black woman because she is mixed race so I am playing on this idea of skin colorism and sees what a better life looks like – at every stage and from every angle “I don’t think we have enough conversa­tions about the power of pretty privilege and pretty politics in the immigrant narra­tive What does upward mobility look like for different people what more could we desire with those powers How much of our strengths do we use just for survival and how much of those strengths do we use to do more than survive – to actually thrive in a society that is capitalistic and where you can have more than what you desire “The other part of the book is sex tour­ism but Marisol came from working at resorts with her mother Tourism is not just at the resorts – it is having other people come and living their best life in the middle of your life There’s a quote that says that others build their heaven on your land If I could have put that quote somewhere in the book “Marisol is looking for that piece of heav­en but can she have it with what she’s been given in this life if she doesn’t take certain matters into her own hands The core is the privilege of upward mobility in the immigrant narrative “A social justice-themed story does not have to be reality based You can still write about social issues in the speculative fiction space The neighborhood this book is set in is a very real neighborhood Read the full interview in the February 2025 issue of Locus While you are here please take a moment to support Locus with a one-time or recurring donation We rely on reader donations to keep the magazine and site going and would like to keep the site paywall free but WE NEED YOUR FINANCIAL SUPPORT to continue quality coverage of the science fiction and fantasy field Copyrighted material may not be republished without permission of LSFF Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" “LOCUS is now an intrinsic part of everything that science fiction is and does a primary resource for innumerable enterprises and a continuing source of information and entertainment.” Locus Magazine and Website cover science fiction and allows us to continue to share our content without a paywall Even a small contribution goes a long way toward keeping Locus going and keeping you up to date with new exciting books and in the know about the SFF world Read this week's magazine Ibi Zoboi debuted to immediate acclaim in 2017 with National Book Award finalist American Street, followed by a procession of other celebrated works. Zoboi’s debut contemporary fantasy, (S)kin (Versify is a novel in verse following an undocumented Caribbean mother and daughter who work for pennies by day then shed their skin to feast on the life force of their enemies at night The duo’s pursuit of the American dream connects them with Genevieve a motherless biracial girl beginning to manifest the same powers PW spoke with Zoboi about pushing the limits of one’s knowledge the untapped potential of Caribbean folklore What drew you to the idea of Caribbean folklore–inspired vampires This has been a long time coming—20 years My first published writing was speculative fiction in adult publications that’s what I was interested in writing I wanted to write speculative fiction for adults because I wanted to do what Octavia Butler was doing At that time I was attending Haitian Vodou ceremonies and immersing myself in the culture I learned that it was a pantheon just as deep and vast as Greek and Roman mythology My first short story was published in 2004, in a book called Dark Matter: Reading the Bones It was called “Old Flesh Song,” and based on the Old Hag folklore I loved the idea of Black women who were domestic workers by day and vengeance-seeking vampires by night but the vampire traditions of the Caribbean You pour your own life experience into your work What motivated the complicated mother-daughter dynamics at play in (S)kin I grew up in a very Catholic household in Haiti you know there’s something different about us I’m learning about Haitian Vodou in school “Where’s the next ceremony I can see?” But I’m keeping it away from my mother we all used to dance to this or knew these songs,” and grew up with this as part of their culture Then you come to a new country and it’s like but they have to keep their abilities a secret Marisol doesn’t know whether she’s assimilating and discarding this part of herself This is the mother-daughter dynamic when you’re an immigrant coming to a new place and hair texture plays a prominent role in how differently Marisol Why was it important to contrast these two so starkly But there are some things that are subconscious in my mind but we didn’t have those words back then Racial dynamics don’t stop at Black and white All of that went into this idea of shedding your skin Would you like to come back to the world of (S)kin I published “Old Flesh Song,” and I revisited it in a short story “The Fire in Your Sky.” Patrice Caldwell edited an anthology It had “Kiss the Sun,” about girls at the resort where Lourdes and Marisol once lived and worked I’ve been visiting this world over and over Return to the main feature. IBI Ag with the participation of The Trendlines Group (SGX:42T) (OTCQX:TRNLY) Consensus Business Group and a grant from the Israel Innovation Authority The company intends to use the funds to consolidate its position in the global agricultural sector assisting farmers in producing more food by protecting their crops and the global food chain adapted from pharma and modified to fit the agricultural market provides new modes of action and represents a revolutionary new approach for protecting crops from insects As part of the 10th edition of the Boat Builder Awards run by IBI and METSTRADE Manitou is thrilled to receive the award for Retail Marketing Initiative as a result of a unique partnership with professional quarterback Kirk Cousins shipyards and their official distributors who have demonstrated a real innovation in sales and marketing initiatives to expand their marketplace Kirk’s authentic passion for the water and the closeness it helps facilitate with his family speaks volumes about Manitou’s goal of creating unforgettable moments on the water This partnership bridges the worlds of pontoon boating and professional sports promising a fusion of excitement and relaxation for enthusiasts of both Highlighted in a four minute longform video the freedom he feels on the water in his Manitou and the memories he can create with his family Kirk Cousins embodies the spirit of excellence and dedication—values that align seamlessly with the Manitou brand Known for his leadership both on and off the field coupled with his strong dedication to family and community “We are thrilled with the amazing results from Manitou’s partnership with Kirk Cousins and I’m honored to accept this prestigious award because of it,” said Jeremi Doyon-Roch “The collaboration between Kirk and Manitou resonated strongly with our target audience and proved that a strong authentic partnership like we have with Kirk can redefine leisure and recreation on the water.” For more information about Manitou pontoons, visit manitoupontoonboats.com and follow on social media: Facebook and Instagram Many products featured on this site were editorially chosen Boating may receive financial compensation for products purchased through this site Copyright © 2025 Boating Firecrown Reproduction in whole or in part without permission is prohibited Business Post head of news Peter O’Dwyer reveals who’s on the move in legal 2025 /PRNewswire/ -- The Integrated Benefits Institute (IBI) is excited to announce its research topics for Q3 and Q4 focusing on themes that will shape the future of workplace benefits and employee well-being and the IBI research committee have identified these as priority topics Work Models and Productivity Optimization - As organizations refine their remote understanding their impact on productivity becomes crucial IBI's research will explore the relationship between work arrangements and business outcomes and identify effective absence management strategies We will assess how technology can enhance productivity while reducing burnout through flexible support systems AI and Digital Transformation in Benefits – This research will address the challenge of integrating AI and automation into benefits management It will explore how AI can streamline administrative processes and identify emerging technologies that support predictive analytics in workforce planning Benefit Navigation and Engagement—The complexity of benefits offerings often confuses employees hindering their ability to fully utilize available resources Our research will focus on effective strategies that increase awareness and usage of benefits and personalized support systems for their impact on employee satisfaction and benefits utilization Caregiving Support and Workforce Sustainability - As caregiving responsibilities increasingly impact workforce productivity employers need effective strategies to help employees balance their work and caregiving demands Our research will analyze the business impact of caregiving responsibilities evaluate various support models—including flexible work arrangements- and measure the ROI of caregiver support programs MEDIA CONTACTColby Gray, CD+M Communications207.563.4646[email protected] The Integrated Benefits Institute (IBI) is excited to announce that twenty two industry leaders will discuss workplace health and productivity at the .. The Integrated Benefits Institute (IBI) today unveiled a report on employers' challenges in incorporating high-cost therapies Human Resource & Workforce Management Surveys, Polls and Research Metrics details The Inflammatory burden Index (IBI) is an effective predictor for a range of malignancies the significance of IBI in esophageal squamous cell carcinoma (ESCC) needs to be further verified The aim of this study was to verify the predictive power of IBI in ESCC undergoing radical resection which comprised 408 ESCC patients randomized into either the primary or validation cohort the nomogram model was also constructed and verified The IBI is significantly related to tumor length the decision curve analyses (DCA) and receiver operating characteristic curve (ROC) confirmed the higher prognostic value of IBI indicating the better clinical applicability In patients with high IBI compared to the low IBI cohort the 5-year CSS was considerably worse (total: 27.0% vs The IBI was shown to be an independent parameter by multivariate analyses (primary: HR = 2.352 with the C-index of 0.675 (0.656–0.695) in the primary set and 0.662 (0.630–0.694) in the validation set for CSS in ESCC an IBI-based nomogram was created and validated The predictive significance of IBI in ESCC patients undergoing radical resection was validated by this investigation IBI may be utilized for preoperative evaluation of ESCC as it was found to be substantially correlated with prognosis To better improve patient prognosis and inform therapeutic decision-making it is crucial to more accurately estimate the prognosis of EC prior to treatment using a range of simple it is unclear which combination of SIR-related indices is useful it is of great clinical significance to explore an indicator that fully reflects the SIR to better predict the prognosis in those with EC this study sought to evaluate the prognostic role of preoperative IBI in esophageal squamous cell carcinoma (ESCC) with radical resection a predictive IBI-based nomogram was also constructed and validated to predict individual survival in patients with ESCC The flow chart of patient selection and study design (A) An overview of the IBI as well as other hematological indices calculation (B) The definitions of the integrated hematological indices (C) patients were checked regularly: first 2 years: every 3 months Data from this study were last followed up in December 2020 and Medcalc 17.6 were used to evaluate the statistical data Based on the death/survival of cancer-specific survival (CSS) the receiver operating characteristic curve (ROC) was used to compare the areas under the curve (AUCs) between IBI and other indices A time-independent ROC and AUC verified the IBI’s prognostic capabilities a tool for assessing the clinical value of various prediction models was also utilized to analyze the difference between IBI and other hematological indices by measuring net income at various probability thresholds Using the restricted cubic spline (RCS) model the appropriate threshold for IBI was obtained by analyzing the non-linear relationship between IBI and CSS RCS regression uses third-order polynomials joined at knot points to model non-linear relationships which is highly relevant to Cox regression model analysis Cox regress analyses were used to identify parameters in CSS that had 95% confidence intervals (CIs) and hazard ratios (HRs) Kaplan-Meier curves were used to compare the variations in CSS By assessing discrimination and calibration in the primary and validation cohorts the results were considered statistically significant The characteristics as well as hematological indices of the two cohorts were displayed in Table 1 along with a number of hematological indicators Since there was no discernible difference between the two cohorts the validation cohort’s findings may offer more reliable validation for the primary cohort The distribution of all the indices in two cohorts (A) The correlation heat map for all SIR-related indices (B) A nonlinear connection between CSS and IBI (C) A positive correlation between IBI and tumor length (E) IBI grouped by tumor stage (F) and death risk (G) To better understand the prognostic value of IBI, DCAs (A-C) and ROCs (D-F) between IBI and other conventional indices were compared. Time-dependent ROC curves (A-C) and AUC curves (D-F) The results also showed the prognostic advantages of IBI (G-L) Univariate (D) and multivariate (E) Cox analyses in the primary cohort Univariate (F) and multivariate (G) Cox analyses in the validation cohort Nomograms in primary (A) and validation (B) cohort. The CCAs showed satisfactory levels of agreements in the primary (C) and validation cohort (D). The ROCs indicated a higher prognostic ability in the primary (E) and validation cohort (F). The DCAs displayed a better clinical applicability in the primary (G) and validation cohort (H). Risk was categorized into high-risk and low-risk groups in the primary (A) and validation cohort (B) The 5-year CSS between the two groups in the primary (C) and validation cohort (D) Sankey diagram with relation to risk stratification in the primary (E) and validation cohort (F) future prognostic improvement will be guided by more improved and composite SIR-related indices The predictive impact of IBI was validated in this investigation and it was found to be much stronger than that of other traditional prognostic indices this study also revealed a worse CSS in patients with high IBI IBI then functions as an independent parameter in two cohorts Between the current study and the prior study the preceding study included a range of EC forms and treatments and these intricate variables might have an impact on the result this study’s results were created in the primary set and validated in the validation set and its samples were larger than those of the previous study no additional conventional indices were included in the prior study for comparison In order to ascertain the IBI’s superiority in the present investigation prognostic values were compared between the IBI and additional classical indices IBI demonstrated the highest predictive power and clinical application on account of ROCs and DCAs making it the best option for SIR-related prognostic stratification in ESCC the hematological indices listed above may not be the same for other cancers because ESCC has unique characteristics and its patients are typically malnourished the current study constructed and validated a predictive nomogram for survival prediction based on IBI The findings of our study shed new light on the prognostic importance of IBI in ESCC It is important to recognize a few of this study’s strengths the findings verified that individuals with ESCC who had higher baseline values of IBI also had higher tumor stages and poorer prognoses the superiority was ascertained by comparing the prognostic values of IBI with other traditional indices IBI demonstrated the best predictive capability in terms of CSS among all the most often used SIR-related indices the great predictive accuracy and low cost and convenience of calculating the IBI from regular laboratory tests suggest that it will likely be highly useful in ESCC daily clinical practice it is hypothesized that IBI could reduce potential biases and improve the utility of prognosis IBI is more accurate and has greater clinical relevance when compared to other hematological indices Adjuvant therapy may be necessary for patients in an advanced stage and greater monitoring may be necessary for those in an earlier stage but it has not been fully promoted due to its price and technology more clinical study findings are needed to determine whether MRD may be used as a prognostic predictor of EC It is important to take into account some of the study’s limitations potential bias was unavoidable in this single-center retrospective research a useful and straightforward index obtained from peripheral blood the fact that individuals who underwent neoadjuvant therapy were not included in this study may have limited the findings additional perspective studies are required to demonstrate the predictive validity of IBI in patients with ESCC who underwent radical resection IBI was verified as a useful and straightforward index Preoperative evaluation may benefit from the relationship between IBI and the tumor’s stage and prognosis Further inquiries can be directed to the corresponding author Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Epidemiology of esophageal cancer: update in global trends Esophageal Cancer: tumor-node-metastasis staging Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment Genomics of esophageal cancer and biomarkers for early detection The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment The prognostic value of preoperative neutrophils monocytes and calculated ratios in patients with laryngeal squamous cell cancer Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer Pretreatment plasma fibrinogen and serum albumin levels predict therapeutic efficacy of concurrent radiochemotherapy for esophageal squamous cell cancer The relationship between NLR/PLR/LMR levels and survival prognosis in patients with non-small cell lung carcinoma treated with immune checkpoint inhibitors Correlation between preoperative peripheral blood NLR LMR and prognosis of patients with head and neck squamous cell carcinoma Clinical significance of systemic immune-inflammation index (SII) and C-reactive protein-to-albumin ratio (CAR) in patients with esophageal cancer: a meta-analysis The preoperative systemic immune-inflammation index is associated with an unfavorable prognosis for patients undergoing curative resection of esophageal squamous cell carcinoma after neoadjuvant therapy Inflammatory burden as a prognostic biomarker for cancer The inflammatory burden index: a promising prognostic predictor in patients with locally advanced gastric cancer Prognostic value of inflammatory burden index in advanced gastric cancer patients undergoing multimodal treatment The inflammatory burden index is a superior systemic inflammation biomarker for the prognosis of non-small cell lung cancer Prognostic value of inflammation-immunity-nutrition score and inflammatory burden index for hepatocellular carcinoma patients after hepatectomy Yin, C. et al. Clinical significance of the preoperative inflammatory burden index in esophageal cancer. Oncology https://doi.org/10.1159/000535727 (2023) Effectiveness and safety of minimally invasive Ivor Lewis and McKeown oesophagectomy in Chinese patients with stage IA-IIIB oesophageal squamous cell cancer: a multicentre non-interventional and observational study Postoperative adjuvant therapy versus surgery alone for stage IIB-III esophageal squamous cell carcinoma: a phase III randomized controlled trial Adjuvant therapeutic modalities following three-field lymph node dissection for stage II/III esophageal squamous cell carcinoma Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals Inflammation-induced cancer: crosstalk between tumours Tumour microenvironment factors shaping the cancer metabolism landscape Inflammation: the incubator of the tumor microenvironment Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis The effect of acupuncture on the expression of inflammatory factors TNF-α IL-6,IL-1 and CRP in cerebral infarction: a protocol of systematic review and meta-analysis Systemic inflammatory response with high CRP values as the dominant symptom of multiple myeloma Tumor-associated neutrophils and neutrophil-targeted cancer therapies Tumor-infiltrating immune cells act as a marker for prognosis in colorectal cancer Tumor-infiltrating lymphocytes: warriors fight against tumors powerfully Inflammatory burden index: association between novel systemic inflammatory biomarkers and prognosis as well as in-hospital complications of patients with aneurysmal subarachnoid hemorrhage Association between inflammatory burden index and unfavorable prognosis after endovascular thrombectomy in acute ischemic stroke Radiomics: extracting more information from medical images using advanced feature analysis CT-based radiomic signatures for prediction of pathologic complete response in esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy Pretreatment CT and 18 F-FDG PET-based radiomic model predicting pathological complete response and loco-regional control following neoadjuvant chemoradiation in oesophageal cancer Molecular residual disease and adjuvant Trial Design in Solid tumors Circulating tumor DNA analysis for detection of minimal residual disease after chemoradiotherapy for localized esophageal cancer Detection of circulating tumor DNA in plasma: a potential biomarker for esophageal adenocarcinoma Download references This study was supported by Zhejiang TCM Science and Technology Project (2021ZB034 and 2022ZB051) Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology JF and QC contributed and designed the current study JF and YX interpreted and analyzed the data JF and QC reviewed the manuscript for important intellectual content critically All authors contributed to the article and approved the final manuscript as submitted version This study was performed in accordance with the Helsinki Declaration and approved by the Ethics Committee of Zhejiang Cancer Hospital (IRB-2021-4) The authors declare no conflict of interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-024-81237-w Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly. here.' data-statistics='This content is blocked. Please accept analytics cookies. You can do this here.'>This content is blocked. Please accept marketing cookies. You can do this here a leading global design and consultancy organization for natural and built assets today announced the grand re-opening of its new office at the base of the Bank of America Plaza tower in downtown Los Angeles This strategic move consolidates the company’s Los Angeles operations and its acquired companies IBI and CRTKL into one location to reinforce the organization’s approach of operating as one Arcadis The consolidation also underscores Arcadis’s capabilities both within the region and around the world Drawing from the rich architectural legacy of CRTKL in the Los Angeles community and the legacy market presence of Arcadis the company is positioned to offer more cross business area solutions for clients As Los Angeles ushers in a transformative era hosting the LA28 Olympic and Paralympic Games Arcadis is poised to help revolutionize the city’s landscape before these megaevents Leveraging its global solutions across environment Arcadis prioritizes sustainability and decarbonization across its projects and is committed to a paradigm shift crucial for urban development in U.S Group Practice Manager US West & Mexico at Arcadis said: “In addition to a focus on environmental stewardship promoting and upholding equity within communities is a core objective of every project By catering to the varied requirements of LA’s diverse communities Arcadis achieves its holistic approach towards inclusive urban planning and development.” Arcadis has laid a foundation for Southern California's evolution across the entertainment and planners have created some of our region’s most iconic landmarks and solutions to address location specific challenges As Arcadis continues to cement its place within the heart of Los Angeles we are proud to serve our clients by guiding them towards a period of sustainable development and innovation within the city and beyond.” Connect with {name} for more information & questions Arcadis will use your name and email address only to respond to your question. More information can be found in our Privacy policy We are 36,000 people active in over 30 countries We support our clients wherever they need us As a part-time yoga teacher and full-time work-from-homer, I live in athleisure. Sweatshirts? You bet. Joggers? A staple. function ga4_link74() { window.dataLayer.push(JSON.parse('{"event":"click_inarticle"}')) }Leggings my choice of footwear is just as comfy-casual as the rest of my clothes What are these magical shoes and where/how/when can I get them Forever on the quest to find the best comfy kicks Editor's Note: Since we first tested Cariuma sneakers Cariuma's Oca Low shoes are similar to their Ibi line If you follow any style influencers on Instagram chances are high you’ve seen Cariuma's sneakers—you may have mistaken the casual low-top sneakers for similar-looking canvas sneakers from Vans or Keds The Brazil-based brand has gained a cult following for its comfortable high-quality shoes that are also “eco-friendly” and meaning no animal products are used in their fabrication Cariuma sneakers also claim to be carbon-neutral with the entire production and shipping process releasing zero net carbon emissions “We make up for the carbon emissions by purchasing carbon offsets creating a footprint balance of zero,” Cariuma’s website explains While we’re function ga4_link77() { window.dataLayer.push(JSON.parse('{"event":"click_inarticle"}')) }skeptical of bold environmental claims the Ibi sneakers seem to indeed have a more sustainable production line than most “We knit our sneakers from bamboo and recycled plastics from heel to toe,” the product description states while the laces and labels are made with recycled plastic bottles and the outsole with sugarcane function ga4_link81() { window.dataLayer.push(JSON.parse('{"event":"click_affiliate","affiliate_merchant":null,"affiliate_network":null,"affiliate_button_type":"button"}')) }Shop Cariuma To say that Cariuma sneakers are comfortable would be a serious understatement I’d argue that they are the most comfortable shoes I’ve ever had the pleasure of wearing I ordered the Ibi sneaker in a size 8—I typically wear an 8 or 8.5—and the fit was great—not too tight Because the knit material is so flexible and the shoe’s interior is just the right amount of spacious the sneakers slip on like a glove and stay on without any dreaded heel chafing They felt like the perfectly worn-in pair of sneakers from the moment I first put them on my feet the Cariuma sneakers are lightweight and the cushioned memory foam insole provides just the right amount of support I wore them during an all-day shopping trip and I can say that these shoes are made for walking Do you like supporting a company that makes a genuine effort to be sustainable If you answered 'yes' to any of these questions but they feel even better—maybe not “walking on clouds” better Besides being more suited for kicking around than for exercise I struggle to find any reason not to buy a pair of these sneakers for yourself they’re pricier than the same-old shoes currently in your Amazon cart but I think I’ve finally met my "solemate." Prices were accurate at the time this article was published but may change over time The Twin Cities literary scene has been vibrant with young publishing houses springing up By far one of the most influential in diversifying the community has been In Black Ink (IBI) The non-profit was founded in 2018 by the Minnesota Regenerative Publishing Project with the mission of helping to “develop and advance the African heritage community in Minnesota in the publishing arts industry.” IBI does so by increasing the access of the publishing industry to Black authors and artists current Mac senior and Creative Writing major Xavier Pittman ’24 began interning with IBI We had the pleasure of chatting with Xavier about his experience working with the trailblazing publishing house reviewing them and sending feedback to my employers and let people know where certain things are at When and why did you first get involved with IBI I got involved with IBI technically my senior year but I was tired of working in the Leonard Center It was very convenient to get stuff done sitting at a desk all day I just happened to see IBI pop up as part of the English department’s list of internships that they sent out “I need to be a part of this.” The mission is to spread Black history from the Twin Cities and make it more known That’s something I strongly wish I had available where I’m from I don’t know anything about Black history there and there’s probably a lot of people that feel the same in Minnesota and all over the country So it felt very important that I be a part of this And I’ve always wanted to use literature to change the world somehow But it was kind of this spur of the moment thing that just feels like destiny Have there been any classes or professors at Macalester that you feel have prepared you to be a part of the greater literary community yes because I am able to think about what I’m reading and what I’m consuming very critically and I’m able to help out in that way with analysis I was able to write about some of the things that I noticed with my fresh eyes and I think my education at Macalester helped me in that sense I feel like there is a lack of Black professors here at Macalester and I’ve obviously been here for quite some time there’s not a lot of professors of color And so I guess I didn’t really have an opportunity for any of them to be like you should check this thing out.” You know it took me a while for me to even know that Walter Greason worked here I think that’s one thing Macalester could improve on Were you able to go to the Coffee House last year when IBI came to promote Karen F especially because in the book there’s a lot of poetry written by a former Macalester student that I had known and talked to So it was kind of surreal seeing someone who I interacted with in the past already and realizing they’re published But also surreal in the fact that I’m involved in it in general I think literature and writing is creating new worlds It’s also changing entire worlds that exist in higher minds Do you have a favorite project you’ve worked on at IBI Working on the Ethel Ray Nance book was really special I got to see a little bit of that whole process beforehand which gave me an idea of what that process looked like before I jumped on the Ethel Ray project I got to go through the entire process of seeing the title page get designed through going on the book tours We went to several places in Duluth and then came down here and toured several places in St In general I’m enjoying getting to know the Black community here and interacting with people more just from the inherent fact that I’m working on these literary projects; they connect you with so many people Do you have any people involved with IBI you consider to be your mentors another person who is a celebrity here at Macalester and role model is Mahmoud El-Kati he has so much wisdom to spread; you talk to him for a second and he’ll give you the entire history of anything He was also very influential at the University of Minnesota in creating the Black Studies Department and he’s been part of all these different orgs too Right now I’m still thinking that I’ll continue to work with IBI maybe full time once I’m done with school and while I will always cherish the time I spent with IBI I do want to take what I’ve learned and spread it elsewhere I’d like to be part of the movements that I’ve read about and helped people know about with IBI I don’t know when that goodbye would happen but in some ways I will always work with them The Words would like to thank Xavier for sharing his experience in the Twin Cities literary community with us We wish him the best of luck as in his English journey at Mac and beyond Copyright ©2025. 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Design, CMS, Hosting & Web Development :: ePublishingCookie Settings Three workers die and seven are injured after the explosion of an industrial boiler in a factory in Ibi The explosion of an industrial boiler in an industrial warehouse in Ibi Alicante dedicated to the manufacture of plastic containers and packaging has caused the death of these three workers and seven injured after the roof and part of the walls of the factory fell According to information from the Information and Coordination Centre for Emergencies of the Generalitat (CICU) “They are young and hard-working people” declared the mayor of Ibi From the diocesan Secretariat of Pastoral Care of Labour we express our pain to their families and friends The loss of life at work and in excessive occasions work accidents is a serious problem that needs to be addressed in depth The Law on the Prevention of Workplace Accidents the prevention training that workers receive and the efforts made by social agents are manifestly insufficient to tackle this serious problem According to data from the National Institute of Statistics (INE) as of September 2024 there have been 880,852 workplace accidents Given this reality, it is necessary to remember that the Social Magisterium of the Church states among the rights of workers the right “to work environments and production processes that do not cause harm to the physical health of workers and do not damage their moral integrity.”[1] People are the true wealth: without them there is no work community Safety at work means safeguarding human resources which have an inestimable value in the eyes of God and also in the eyes of the true employer It is necessary to support their struggles making visible the work accidents and the loss of health in the workplace From the Diocesan Secretariat of Pastoral Care of Labor we support the workers who strive to dignify work [1] Compendium of the Social Doctrine of the Church Reflection by Bishop Enrique Díaz: I will praise you Paris Marks 400th Anniversary of the Congregation of the Mission Reflection by Bishop Enrique Díaz: The Lord’s mercy is eternal Tweets by Pontifex Get these stylish shoes for up to 50 percent off An official website of the United States government JavaScript appears to be disabled on this computer. Please click here to see any active alerts The number and abundance of species in a plant community changes over time in response to both natural and human-caused disturbances The CWMP monitors the wetland plant community in up to 3 different vegetation zones (wet meadow emergent and submerged aquatic vegetation) at each sampling site Different vegetation zones create different habitats for wildlife communities The CWMP uses a vegetation Index of Biotic Integrity (IBI) to assess plant community health in monitored coastal wetlands Vegetation IBI results from 2011-2018 demonstrate that Lakes Superior Michigan and Huron tend to have less degraded wetland vegetation (higher IBI scores) than wetlands in Lakes Erie and Ontario (Figure 1) More degraded plant communities in Lakes Erie and Ontario are due to greater amounts of human disturbance nutrient runoff and invasive species as compared to the other lakes The CWMP also provides important information about the presence and abundance of invasive plants such as invasive cattails (Typha angustifolia) and Phragmites These data are important in planning restoration projects and evaluating their success Freshwater macroinvertebrates are a diverse group of organisms that are small yet visible to the naked eye and inhabit freshwater aquatic environments such as wetlands lakes and streams at some point during their life cycle Macroinvertebrates play a critical role in coastal wetland food webs serving as an important food source for many organisms The CWMP monitors the wetland macroinvertebrate community in different vegetation zones at each site using D-frame dip nets Samples are preserved and the macroinvertebrate species are identified and recorded The CWMP uses a macroinvertebrate IBI to evaluate macroinvertebrate community health in monitored coastal wetlands Macroinvertebrate IBI results from 2011-2018 show that each of the Great Lakes have wetlands with healthy macroinvertebrate communities and degraded communities (Figure 2) Macroinvertebrate data are less available in Lakes Erie and Ontario because wetlands in these lakes are commonly dominated by invasive plants and do not have the vegetation zones (wet meadow emergent and submerged aquatic vegetation) where macroinvertebrates must be collected for IBI calculations including game fish and those important for commercial fisheries rely on coastal wetlands at some point in their life cycle These fish species rely on specific coastal habitats for feeding spawning or protection while fish larvae develop into juveniles (nursery habitat) Coastal wetlands across the Great Lakes Basin vary seasonally and spatially in the diversity of fish species present The presence of emergent and submerged aquatic vegetation pH and level of dissolved oxygen in the water column influence the type of fish species present and their abundance in a coastal wetland The CWMP monitors the wetland fish community at each site by deploying nets in different vegetation zones overnight Fish survey data are used to compute a fish IBI which is an indicator of fish community health Each of the Great Lakes have wetlands with healthy fish communities as well as wetlands with degraded fish communities based on the fish IBI (Figure 3) The CWMP provides important information about the presence and abundance of non-native and invasive fish species Non-native and invasive fish are found in all the Great Lakes and connecting rivers but Lake Erie wetlands tend to have more invasive fish species than wetlands in the other lakes Larger numbers of non-native fish species can reflect reduced ecosystem health This information is helpful for resource managers Coastal wetlands are a key habitat for frogs and toads (referred to collectively as anurans) Thirteen species of frogs and two species of toads are known to inhabit coastal wetlands across the Great Lakes Basin the CWMP has not documented the presence of any non-native frogs or toads at monitored sites Anurans play an important role in the Great Lakes coastal wetland food web as anuran eggs The CWMP monitors the wetland anuran community at each site by visiting one or more locations at night during the breeding season and listening for the distinct calls of the different frog and toad species Anuran survey data are used to calculate an anuran Index of Ecological Condition (IEC) score Data from 2011-2018 show that wetlands in Lakes Superior Michigan and Huron tend to have less degraded anuran communities (higher anuran IEC scores) than wetlands in Lakes Erie and Ontario but that a range of conditions can be found in each lake (Figure 4) In addition to providing information about wetland health CWMP anuran data provide important information about the presence and abundance of threatened anuran species as well as species of special concern The Great Lakes coastal wetlands represent critical habitat for over 340 breeding resident and migratory bird species that depend upon these important ecosystems for food plant community and adjacent land use all influence bird community composition and health in Great Lakes coastal wetlands Data from CWMP bird surveys are used to calculate a bird IEC Bird IEC scores from 2011-2018 show that each of the Great Lakes has wetlands with healthy bird communities and wetlands with degraded communities (Figure 5) Wetlands with degraded bird communities often have degraded plant communities CWMP bird data are useful for identifying wetlands that need habitat restoration and for tracking the presence and abundance of endangered and threatened birds in the Great Lakes Basin such as those that are wetland specialists or those that instinctively return to the wetland where they were hatched are particularly vulnerable to habitat degradation and wetland loss CWMP data also are useful in wetland protection efforts Back to: About the Great Lakes Coastal Wetland Monitoring Program The Italian Biochar Association (ICHAR) and the International Biochar Initiative (IBI) invite biochar industry professionals to an immersive exploration of biochar’s potential in the heart of Italy the annual event known as the IBI Biochar Study Tour will be held in Florence from October 16 to 18 Attendees will be able to gain firsthand knowledge of cutting-edge biochar projects as they network with peers The expert-led program delves into biochar production Relevant: Hamerkop & The International Biochar Initiative Released New Guide On Biochar Certification This year’s tour focuses on the remarkable Chianti region where event participants will learn how biochar is revolutionizing vineyard management by boosting production without compromising grape quality while also enhancing soil health and mitigating climate change Experience the beauty of Tuscany while discovering how biochar is being harnessed to create a more sustainable future Don’t miss this opportunity to explore biochar’s potential in the vineyard. Early bird registration is open until July 31st with only 80 spaces available Relevant: First Year Field Trials Of Biochar Show 16% Higher Grassland Yields Biochar offers numerous benefits for grapevines and the soil they inhabit This carbon-rich material significantly improves soil health and productivity Competition for space appears to be normalizing. Customers continued to expand across markets, but at a less frenzied pace relative to the last few years. Customers have been more deliberate in their decision-making, expanding the time between proposals and lease signings. The U.S. vacancy rate ticked up to 4% this quarter.  The utilization rate stabilized at 84.8% in July. The utilization rate averaged in the optimal range at 85.3% in Q2 2023, revealing a lack of shadow space.  U.S. consumers demonstrated a willingness to spend as their pricing power grew. Nominal core retail sales (ex-auto and gas) rose at an annual rate of 4% in Q2, twice the rate of e-commerce, as the pace of wage growth exceeded inflation. The inventory-to-sales ratio has stabilized at 1.2 over the last three months as the pandemic-driven bullwhip effect faded. Instead, inventory levels are largely returning to a normal seasonal pattern that aligns with consumption growth.  Construction starts declined in Q2 which could put downward pressure on availabilities in 2024. Construction starts were 74 MSF in Q2 2023, down 13% from 84 MSF in Q1 2023.  True months of supply (TMS) rose to 36.5 months. TMS (the amount of time it would take to absorb all available supply at the current demand run rate), saw an increase of 6.5 months from the prior quarter. The uptick was consistent with normalizing operating conditions and rising rents. (TMS less than 50 months corresponds with positive real rent growth.)  We expect vacancy rates to tick up and rent growth to decelerate in 2023. Expanding leasing decision-making timelines will likely push some takeup of space into 2024. Coupled with a dip in supply, we expect availabilities to decrease in 2024 as deliveries fall short of demand. We foresee positive real rent growth through the near term, fueled by rising replacement costs, growing barriers to new supply and ongoing secular drivers to demand.  As the core part of this partnership, the IBI Biochar Standard, the industry’s first material standard, will merge with CSI’s World Biochar Certificate.An expert group led by the biochar researcher and IBI Founding Member Dr Johannes Lehmann of Cornell University will be installed to be consulted in the future on further developments of the standard including consideration of elements of the legacy IBI Standard Relevant: Highlights From The International Biochar Initiative’s 2023 Virtual Symposium Ensuring the highest quality and safest biochar has been the hallmark of the IBI Standard since its launch in 2015 Through merging this legacy with CSI’s updated World Biochar Certificate the industry will create increased assurance regarding the reliability and safety of biochar both as part of carbon markets and for the physical biochar itself IBI continues to work to support it with partnerships that create confidence in biochar systems Merging IBI’s legacy standard with the World Biochar Certificate and creating new education programs to support the companies seeking certification creates new value for the entire biochar ecosystem Relevant: Opinion: Biochar – The Circular System At The Heart Of The Carbon Negative Revolution The International Biochar Initiative members can also receive discounts on education programs, expected to launch later in 2024, creating a pathway to certification that is cost effective and accessible. There will be additional benefits for IBI members, which we will be happy to inform you about in the coming months. One-of-a-kind event marks the Day of the Holy Innocents with lively flour and egg fight Get the latest news and updates straight to your inbox Oman urges tourists to dress modestly, respect customs Dubai Police to conduct mock drills at Al Warsan Area TikTok users mock tariffs with Nike, Lululemon deals Volume 14 - 2020 | https://doi.org/10.3389/fncel.2020.00285 chronic atypical antipsychotic administration produces a significant reduction in or even complete remission of psychotic symptoms such as hallucinations and delusions these drugs are not effective in improving cognitive and emotional deficits in patients with schizophrenia Atypical antipsychotic drugs have a high affinity for the dopamine D2 receptor and a modest affinity for the serotonin 5-HT2A receptor The cognitive and emotional deficits in schizophrenia are thought to involve neural networks beyond the classical dopaminergic mesolimbic pathway an extracellular matrix protein involved in neural development and synaptic plasticity are associated with neurodevelopmental disorders such as schizophrenia and autism spectrum disorder hippocampal Reelin levels are down-regulated in the brains of both schizophrenic patients and in rodent models of schizophrenia we investigated the effect of Reelin microinjection into the mouse hippocampus on behavioral phenotypes to evaluate the role of Reelin in neurodevelopmental disorders and to test a therapeutic approach that extends beyond classical monoamine targets To model the cognitive and emotional deficits as well as histological decreases in Reelin-positive cell numbers and hippocampal synaptoporin distribution offspring that were prenatally exposed to maternal immune activation were used Microinjections of recombinant Reelin protein into the hippocampus rescued impairments in object memory and anxiety-like behavior and recruited synaptoporin in the hippocampus in offspring exposed to antenatal inflammation These results suggest that Reelin supplementation has the potential to treat cognitive and emotional impairments in patients with neurodevelopmental disorders such as schizophrenia Novel therapeutic drugs with strategic targets beyond the classical monoaminergic pathway are required to improve both cognitive deficits and emotional symptoms Reelin injection into the brain to activate Reelin signaling pathways may thus be a novel therapeutic strategy for the treatment of neurodevelopmental disorders To evaluate the effects of Reelin protein signaling activation in the brain we injected recombinant Reelin protein into the hippocampi of adult offspring of pregnant C57BL/6J mice that were intraperitoneally treated with poly I:C on GD 9 this is the first experimental study to investigate the effects of Reelin signaling activation as a therapeutic strategy for cognitive and emotional deficits and synaptic disturbances in an MIA-induced preclinical model of neurodevelopmental disorders Pregnant C57BL/6J mice at GD 6–7 were obtained from Japan SLC Inc Dams were housed individually and habituated to the testing facility for a few days before experimental use Mice were kept in a regulated environment (24 ± 1°C 55 ± 5% humidity) under a 12-h light/dark cycle (lights on 7:45 a.m.) and provided food and tap water ad libitum All experimental protocols including the use of laboratory animals were approved by the Animal Ethics Board of Meijo University and followed the guidelines of the Japanese Pharmacological Society (Folia Pharmacol 99: 35A); the Interministerial Decree of May 25th Japan); and the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publications No All efforts were made to minimize animal suffering and to reduce the number of animals used At GD 9, pregnant mice received intraperitoneal injections of poly I:C (20 mg/kg; Sigma-Aldrich, St. Louis, MO) (i.p.), as previously (Esslinger et al., 2016; Gonzalez-Liencres et al., 2016) Control mice received intraperitoneal injections of sterile saline (0.9%) pregnant mice were singly housed until parturition Offspring were weaned and sexed on postnatal day (PD) 28 and littermates of the same sex were housed in groups of 3–6 animals per cage Both experimental groups (vehicle and poly I:C) were composed of multiple independent litters to prevent litter effects All litters included offspring of both sexes Behavioral analyses in the offspring of both saline- and poly I:C-treated dams were conducted at 8–20 weeks of age To test for a rescue of the cognitive and emotional deficits seen in the MIA model of schizophrenia by recombinant Reelin injection into the hippocampus we used a novel object recognition test on Day 4 post Reelin microinjection (Day 0) We then used the open-field test on Day 10 post microinjection Novel object recognition, a spontaneous form of memory, is derived from curiosity about novel objects (Leger et al., 2013). A novel object recognition test was performed, as described previously (Ibi et al., 2017) Male and female mice were individually habituated to an open box (30 × 30 × 35 cm high) for 3 days two novel objects were placed in the open field and animals were allowed to explore the objects for 10 min under moderate light (20 lux) animals were placed into the same box 24 hr after the training session One of the familiar objects used during the training sessions was replaced by a novel object and the mice were allowed to explore the box freely for 5 min A preference index for the retention session (the ratio of time spent exploring the novel object over the total time spent exploring both objects) was calculated to measure novel object recognition a preference index was also calculated as the ratio of time spent exploring the object that would be replaced by a novel object in the retention session to the total exploration time The time spent exploring each object in both sessions was also recorded on video for subsequent blind scoring The open-field was further divided into an inner square (40 × 40 cm) and an outer area (50 × 50 cm) Mouse movement was measured via a camera mounted directly above the open-field Measurements included distance and time spent in the inner and outer sections Each mouse was placed in a standard transparent rectangular rodent cage (25 × 30 × 18 cm) under moderate illumination conditions (15 lux) Locomotor activity was measured for 120 min using an automated system of digital counters with infrared sensors (Scanet SV-10; Melquest Co. Mice were deeply anesthetized with ethyl carbamate (1.5 g/kg i.p. Japan) and perfused transcardially with saline followed by 4% paraformaldehyde in 0.1 M phosphate-buffered saline (PBS Twenty micrometer-thick coronal free-floating brain sections were made using a cryostat Free-floating sections were transferred to 24-well dishes containing PBS After blocking with 10% goat serum/PBS for 60 min mouse anti-synaptophysin (Sigma-Aldrich SAB4200544 rabbit anti-synaptoporin (Synaptic Systems mouse anti-Reelin (Merck-Millipore MAB5364 and rat anti-somatostatin (SST) antibodies (Merck-Millipore MAB354 1:350) diluted in 10% goat serum/PBS were applied to the sections which were then incubated overnight at 4°C goat anti-mouse Alexa Fluor 568 and anti-rabbit Alexa Fluor 488 antibodies (1:3000; Invitrogen OR) were added to the sections for 2 hr at room temperature Samples were imaged using an all-in-one Fluorescence Microscope (BZ-700 Japan) and a confocal-laser scanning microscope (LSM 800; Zeiss For quantification of the number of Reelin- the number of hippocampal immunoreactive cells (Bregma -1.70 to -2.18 mm) in both hemispheres was counted These analyses were performed by a blinded experimenter Statistical analyses were performed and figures were produced using Prism software version 6 (GraphPad Software As it was not possible to assume that behavioral data had a Gaussian distribution these data are expressed as medians and interquartile ranges Group-wise differences were evaluated using the Mann-Whitney U-test for comparisons between two groups Quantitative values obtained from immunohistochemistry are expressed as means ± standard errors (SEs) Unpaired t-tests were used to compare two groups Two-way ANOVAs followed by Tukey-Kramer post hoc test was used for multiple comparisons where relevant (e.g. Reelin injection and maternal poly I:C treatment) The percentage of aborted pregnancies was evaluated using a chi-square (x2) test The criterion for statistical significance was p < 0.05 After acute administration of 20 mg/kg polyI:C (i.p.) at GD 9, pregnant C57BL6J mice had a significantly increased percentage of aborted pregnancies [vehicle 25% (2/8), poly I:C 86% (43/50); x2 = 14.76, p < 0.001], including either fetal resorptions (abdominal collapse without abortion of the dead fetuses) or frank abortions (premature discharge of dead fetuses). This result was consistent with a previous study (Ehninger et al., 2012) MIA did not affect adult offspring body weight at 9–12 weeks of age (mean ± SE: vehicle 23.53 ± 0.68 g offspring with MIA were viable and did not display any gross histological abnormalities in the hippocampus (data not shown) These results suggest that MIA negatively affected birth rate but not offspring growth or the gross structure of offspring hippocampal layers Hippocampal Reelin expression in MIA offspring Representative photographs showing Reelin-positive cells (arrows) in hippocampal subregions (A) Quantification of Reelin-positive neuron numbers in hippocampal subregions (B) Representative photographs of double-immunostained Reelin- and SST-positive cells (arrows: Reelin-positive/SST-positive arrowhead: Reelin-negative/SST-positive) in offspring hippocampi (C) Percentage of Reelin-positive cells among SST-positive cells in offspring hippocampi (D) Values are means ± SE [Reelin staining n = 6–9 (vehicle: 5 males and a female Reelin and SOM double-staining n = 3 (each group: 2 males and a female); from three independent dams] Two-tailed t-test comparing MIA offspring vs vehicle-treated control group offspring (B,D) the number of Reelin/SST double-positive cells (mean ± SE: vehicle 8.18 ± 0.88 p < 0.001) and SST-positive cells (means ± SE: vehicle 16.36 ± 1.78 p < 0.01) in the hippocampal DG was also significantly decreased by MIA Previous research has implicated deficits in PV-positive GABAergic interneurons in the pathogenesis of schizophrenia (Jaaro-Peled et al., 2010) we investigated the number of hippocampal PV-positive interneurons in MIA offspring here Offspring hippocampal PV-positive interneuron numbers were not changed by MIA (mean ± SE; CA1 region: vehicle 4.06 ± 0.34 p = 0.35; CA3 region: vehicle 3.86 ± 0.53 these results demonstrate that MIA reduced both Reelin- and SST-positive interneurons but did not change the number of PV-positive neurons Multiple lines of evidence implicate synaptic dysfunction in the hippocampus in schizophrenia symptomatology (Tamminga et al., 2012; Osimo et al., 2018). For example, decreased hippocampal synaptic protein and mRNA levels in patients with schizophrenia have been previously reported (Osimo et al., 2018) we examined levels of hippocampal synaptic markers in offspring with MIA in the present study Hippocampal synaptic markers in MIA offspring Representative photographs showing synaptophysin (A) and synaptoporin (C) immunoreactivity in offspring hippocampi Quantification of offspring hippocampal synaptophysin (B) and synaptoporin (D) immunoreactivity Values are means ± SE [synaptophysin staining n = 4 (each group: 4 males) synaptoporin staining (each group: 2 males and a female); from three independent dams)] Effect of Reelin injection into the hippocampus on the abnormal behavior of MIA offspring Experimental schedule for Reelin injection into the hippocampus and subsequent assays (A) Exploratory preference (B) and total exploration time (C) on the novel object recognition test The test session was carried out 24 h after the training session The time spent in the inside/outside (inner/outer ratio) of the field (D) and total distance traveled (E) in the open-field test in which mice were allowed to explore the open field freely for 60 min Exploratory behaviors were analyzed only in the final 30 min of the task due to consistent hyperactivity during the first 30 min Values represent medians and interquartile ranges [novel object recognition test n = 8–12 (control-vehicle: 4 males and 4 females open-field test n = 8–12 (control-vehicle: 4 males and 4 females reelin-poly I:C: 6 males and 6 females); from three or more independent dams] Tukey-Kramer test *p < 0.05 in the comparison between MIA offspring with hippocampal Reelin injection vs #p < 0.05 for MIA offspring with hippocampal Reelin vs This suggests that MIA impairs object recognition in offspring Deficits in object recognition were rescued with hippocampal Reelin injection, as these mice had significantly higher exploratory preference to the novel object than those of MIA-exposed offspring without Reelin supplementation. Finally, there was no difference in total object exploration time between the training and test sessions among all groups (Figure 3C: Training session FPoly  I:C (1,34) = 0.11 Test session FPoly  I:C (1,34) = 0.56 suggesting that neither MIA nor Reelin injection affected exploratory behaviors and/or motor function these results demonstrate that MIA impaired object recognition in offspring which was rescued by hippocampal Reelin injection suggesting that neither MIA nor hippocampal Reelin treatment affected exploratory behaviors or motor function in the open-field test These results demonstrate that MIA increased anxiety-like behaviors in offspring which were suppressed by hippocampal Reelin injection demonstrating that Reelin supplementation may reverse MIA-induced mossy fiber deficits Effect of Reelin injection into the hippocampus on synaptoporin levels in MIA offspring Experimental schedule of Reelin injection into the hippocampus and subsequent assays (A) Representative photographs showing synaptoporin immunoreactivity in the hippocampi of MIA offspring (B) Quantification of hippocampal synaptoporin immunoreactivity in offspring (C) Values indicate means ± SE [n = 3–6 (control-vehicle: 3 males and a female reelin-poly I:C: 3 males and 3 females); from three independent dams] Tukey-Kramer test #p < 0.05 in the comparison between MIA offspring with hippocampal Reelin injection vs These results indicate that Reelin may be a new molecular target for the treatment of neurodevelopmental disorders indicating that synaptoporin expression may be a good marker for hippocampal synaptic disturbances in schizophrenia we demonstrated synaptoporin deficit in MIA offspring even in the absence of gross anatomical alterations in the brain or neuronal loss Our findings support the hypothesis that neurodevelopmental disturbances are central to the etiopathogenesis and disease progression of neurodevelopmental disorders the molecular mechanisms by which Reelin recovers brain dysfunction in MIA remain unknown Further study in preclinical models of neurodevelopmental disorders is required to clarify the effects of Reelin downstream from its lipoprotein receptors These previous findings raise a possibility that recombinant Reelin injection into the hippocampus activates the Reelin receptors (i.e. ApoER and VLDLR) around the hippocampal DG leading to the enhancement of synapse formation/function as well as cognition These effects may be supposedly maintained in a certain period of time even though injected recombinant Reelin had been degraded in a few hours after the injection Further study is required to elucidate the mechanism underlying the long-lasting effect of injected Reelin on synapse and cognition This suggests that hypermethylation of the RELN promoter in both animal models and in patients with neurodevelopmental disorders epigenetically suppresses Reelin expression in the hippocampus leading to cognitive and synaptic disturbances The release of this suppression from hypermethylation of the RELN promoter may thus decrease down-regulation of Reelin protein expression in the brain which could serve as an alternative therapeutic strategy to direct Reelin injection in the brain Inhibition of ADAMTS-3 may therefore reduce the amount of inactive Reelin and help to improve the symptoms seen in neurodevelopmental disorders Futures studies should examine these impacts preclinically for potential translation to humans For the further verification of validity as an animal model of schizophrenia memory function in the present MIA model should be investigated in future studies by using such behavioral cognitive tests All datasets presented in this study are included in the article/Supplementary Material The animal study was reviewed and approved by the Animal Ethics Board of Meijo University and MHa helped with purification of recombinant Reelin protein This research was supported by research grants from the Ministry of Education Science and Technology of Japan; the Ministry of Health Labour and Welfare of Japan; the Japan Agency for Medical Research and Development (AMED) under grant no JP20dm0107087; the Scientific Research on Innovative Areas “Glial assembly: a new regulatory machinery of brain function and disorders” program; the Scientific Research on Innovative Areas “Comprehensive Brain Science Network” program; and the Uehara Memorial Foundation (to DI and KY) YOKOYAMA Foundation for Clinical Pharmacology (YRY-1909) The Research Foundation for Pharmaceutical Sciences and the Research Center for Pathogenesis of Intractable Disease from the Research Institute of Meijo University (to DI and MHi) The Japan Society for the Promotion of Science 17H04252 (to ToN) and 17H04031 and 20H03428 (to KY) were also used to fund this study The Matching Fund Subsidy for Private Universities and the Private University Research Branding Project of the Japanese Ministry of Education Science and Technology (MEXT) purchased the confocal laser scanning fluorescence microscopy used in this study The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The authors would like to thank the Division for Research of Laboratory Animals of Meijo University for their technical assistance The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fncel.2020.00285/full#supplementary-material Modeling madness in mice: one piece at a time PubMed Abstract | CrossRef Full Text | Google Scholar Suppression of serotonin neuron firing increases aggression in mice Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism RNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia Differential survival of Cajal-Retzius cells in organotypic cultures of hippocampus and neocortex Dentate granule cells in 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Daisuke Ibi, aWJpZEBtZWlqby11LmFjLmpw; Kiyofumi Yamada, a3lhbWFkYUBtZWQubmFnb3lhLXUuYWMuanA= †These authors have contributed equally to this work Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish even as demand returned to more normal levels Logistics users absorbed 60 MSF in Q1 2023 in line with the years leading up to the pandemic IBI activity of 56.2 in April equates to an annual demand run rate of approximately 242 MSF The utilization rate stabilized in the 85-86% range The utilization rate averaged 85.6% in Q1 2023 and was 84.9% in April Construction starts dropped by 40% compared with the average pace of starts from Q1 through Q3 2022 due to increased costs and a lack of financing Combined with delayed decision-making and potential for improvement in the economic backdrop the future reduction in deliveries could produce another year of declining and ultra-low vacancies in 2024 given the abundance of speculative space under construction vacancy rates are expected to remain below 2019 levels given limited current availabilities and few unleased buildings in the pipeline True months of supply (TMS) increased to 30 months TMS (the amount of time it would take to absorb all available supply at the current demand run rate) was up five months from Q4 it remains very low on an absolute basis and consistent with positive real rent growth Markets and submarkets with the largest construction pipelines leading to growing differentiation in availabilities and rent growth by location we expect rents to increase by 10% for the year given the data so far this year—specifically 275 MSF of net absorption and deliveries of 445 MSF Macroeconomic crosscurrents may lead to some delayed decision-making which could push demand from 2023 into 2024 vacancy rate should drift up to the low-/ mid-4% range by year-end New supply should drop off sharply in 2024 raising the potential for demand to outpace supply and pulling the vacancy rate down to the mid-3% range by year-end 2024 TMS is poised to drift higher later this year and then retreat below 30 into 2024 consistent with re-accelerating rent growth The current macroeconomic environment has impacted construction development more than demand thus far particularly in the most sought-after markets where vacancies will remain lower with new supply forecasted to drop off heading into 2024 !function(){"use strict";window.addEventListener("message",(function(a){if(void 0!==a.data["datawrapper-height"]){var e=document.querySelectorAll("iframe");for(var t in a.data["datawrapper-height"])for(var r=0;r on a wholly owned basis or through co-investment ventures properties  and development projects expected to total approximately  1.2 billion square feet (111 million square meters) in 19 countries Prologis leases modern logistics facilities to a diverse base of approximately 6,600 customers principally across two major categories: business-to-business and retail/online fulfillment Inverness Caledonian Thistle FC are delighted to announce that IBI are the new sleeve sponsor for the first team kit for season 2024/25.  IBI are an ambitious and growing family owned Building and Construction company based in Inverness with a breadth of skills across the construction industry and one of the largest Joinery Contractors in the Highlands.   ICT Commercial Director Keith Haggart said:- “Brian and Sherrel at IBI have been generously supporting the Club through trackside advertising for a couple of seasons now and we’re thrilled that they are now going to be part of our official kit in our historic 30th Anniversary year.  We look forward to progressing our partnership throughout the course of the campaign.” founder and Managing Director of IBI Joiners said:- it’s an honour to take our partnership with Inverness Caledonian Thistle to the next level in such a milestone year for the club With my family being such great supporters of the club the decision was easy when I was presented with the opportunity to become sleeve sponsor We’re excited and proud to see our name on the shirt and to continue supporting a team that means so much to the community.” Forty-four Jamaicans have been installed as ambassadors under the Governor-General’s ‘I Believe Initiative’ (IBI) pinned the new inductees during a ceremony on Thursday (Dec a declaration of purpose and the celebration of potential its values and its boundless possibilities.” The Governor-General charged the ambassadors to “stay L.I.T,” meaning to Lead with vision; Inspire through service; and Transform your community they will be required to see obstacles as opportunities envision a brighter future and to chart a bold path forward “Inspire through service is to extend our hands and hearts to others providing hope and encouragement; while to Transform communities the ultimate reward is enriching not only the lives of those we serve but also our own because in serving others you are broadening your perspective in life,” he said The Governor-General underscored that the IBI represents a commitment to positive change – countering destructive attitudes and actions by illuminating good values leadership is not a title; it is a torch that lights the way for others Inspiration is not a performance; it is a promise to serve with integrity and heart Transformation is not a distant goal; it is the sum of every decision you make,” he said He encouraged the new ambassadors to stay focused and be undeterred by negativity and distractions “Let us remain committed to doing good and creating a brighter future servants with purpose and change makers with a steadfast commitment to leaving the world better than we found it,” the Governor-General said IBI is a values-based initiative under the Governor-General’s Programme for Excellence (GGPE) It was inspired by the Governor-General’s inaugural speech in 2009 which encouraged all Jamaicans to develop a sense of self-assurance and national pride serves as the secretariat for the two major social programmes affiliated with the Office of the Governor General the other being the Governor General’s Achievement Awards The programmes are designed to help with focusing efforts on the most critical areas of personal and community development Send An Email Get the latest news & updates from the JIS sent to your inbox Partnership provides IBI clients with plug-and-play technology including access to international trading markets 2024 /PRNewswire/ -- ViewTrade Holding Corporation ("ViewTrade") and IBI Investment House ("IBI") today announced a strategic partnership to provide IBI clients with unprecedented access to international trading markets through a new retail trading experience powered by ViewTrade's NextGen platform By tapping into NextGen's suite of front- and back-end capabilities IBI's trading and wealth management customers will benefit from a refreshed modern user experience providing seamless functionality for trade execution In addition to international market access IBI clients will benefit from ViewTrade's support for fractional share trading equity options trading and other in-demand products and can seamlessly add other products via ViewTrade over time ViewTrade's focus areas for expansion in 2024 include fixed income trading among other enhancements to both the range of supported products and to platform administration NextGen platform functionality also includes support for: "We are thrilled to continue in joining forces with IBI Investment House to provide their clients with our cutting-edge NextGen solutions and new products and services helping to ensure that their clients will have a seamless trading experience in the exciting US markets," said Moran Zur ViewTrade's Regional Manager - Europe & Israel "This partnership marks an exciting milestone for us as we continue our mission to expand globally and empower more investors worldwide." CEO of Israel Brokerage and Investments at IBI Investment House echoed this sentiment saying "We are excited to be partnering with ViewTrade to utilize their NextGen solutions By leveraging the capabilities of ViewTrade's NextGen platform alongside our own technology developed in-house we can equip our clients with powerful tools such as customizable trading windows and advanced charts and graphs to ensure that they have a seamless trading experience By tapping ViewTrade's expertise in delivering technology and brokerage solutions that enable access to the global markets IBI can focus on delivering a range of experiences tailored specifically to the unique needs of Israeli investors." IBI Investment House is one of Israel's leading most creative and innovative investment houses IBI brings long-standing experience on the capital market and provides specialized solutions in numerous financial areas for tens of thousands of private institutional and corporate clients in Israel and overseas the independent trading department of the stock exchange member IBI provides supervised independent trading services in Israel and around the world to most of the institutional entities in the capital market and to many of the foreign investment houses operating in Israel The company is considered the leader and the largest among the independent brokerage companies Israel Brokerage and Investments - IBI LTD a member of the Tel Aviv Stock Exchange and the Stock Exchange Clearing House since 1973 To learn more, visit https://www.ibi.co.il/ or email [email protected] ViewTrade is the force that powers cross-border investing for financial services firms throughout the world support and brokerage services that business innovators need to quickly launch or enhance a retail investing experience our approach has helped 300+ firms – from technology startups to large banks brokers and advisors – create the differentiating investment experiences their customers demand With clients in over 20 countries and a team that brings decades of experience and understanding of brokerage technology and services we help our business clients deliver the investment access and financial solutions they require For more information, visit https://viewtrade.com/ and follow the company on LinkedIn Securities and brokerage services provided by ViewTrade Securities Inc ("ViewTrade Securities") a broker-dealer registered with the Securities and Exchange Commission (SEC) and a member of the Financial Industry Regulatory Authority (FINRA) and SIPC Technology and business solutions provided by Orbis Systems Inc are affiliated and collectively referred to (with other affiliates) as "ViewTrade" This communication is not an offer to buy or sell securities and is not a recommendation regarding any investment or investment strategy Investing involves risks and past performance is no guarantee of future results Media ContactSam RaffalliForefront Communications for ViewTrade[email protected] Lancement du fournisseur mondial de solutions technologiques d'investissement et de négociation ViewTrade Holding Corporation en Australie Der globale Anbieter von Anlage- und Handelstechnologielösungen ViewTrade Holding Corporation ist in Australien gestartet Banking & Financial Services Computer & Electronics Financial Technology Financial Technology Select your country or region to see content tailored to your country Recruiting fraud is a growing issue for many companies The Trade Desk takes this issue seriously and is taking steps to address it In our world of screens and distractions, getting audience engagement in advertising is not easy. Less than 1 percent of global users on the open web will ever click on an ad, and with formats like Connected TV (CTV) and digital out-of-home (DOOH) there’s no way for a user to click on an ad even if they wanted to That means if you only use clicks to measure the success of your campaigns you’re missing out on part of the story At the same time, ads still have the ability to influence people — but how do you measure that? You need better signals to understand how your audience is moving from awareness to consideration and conversion, especially as people use different devices to discover new brands, research products, and make purchase decisions. Our Inferred Brand Intent (IBI) is a free first-to-market solution that can help you to connect those dots to better understand how your ads are influencing your audience’s online browsing behavior Setting up Inferred Brand Intent (IBI) for your campaigns on our platform starts with defining a short list of keywords that are closely tied to your brand’s product here are some examples of IBI keyword strategies by category: Whenever someone is exposed to your ads on certain websites IBI analyzes the URLs of the webpages that they’re visiting and looks for the keywords you have selected IBI first looks at whether a user has visited a URL with at least one of your keywords one hour before the impression IBI counts all visits within the first hour afterward as conversions IBI uses an hourlong window because depending on how your frequency caps are set having a window longer than one hour creates the potential for overlap with other impressions served to the customer we try to isolate the impact of that single ad on customer browsing behavior let’s say two different customers are exposed to an ad for a new electric vehicle who was already researching articles on electric vehicles might be served an electric vehicle ad based on their browsing behavior If Customer A continues to research electric vehicles in the hour following exposure to the ad they would not be counted as an IBI conversion who started researching articles on electric vehicles within the hourlong window after they received the electric vehicle ad we can infer that the ad exposure helped drive intent.  Inform campaign strategy with unique insights  IBI can give brands the ability to infer customer intent based on whether they’re researching sites with related keywords after being exposed to omnichannel ads, from desktop to mobile to Connected TV (CTV) and more. Although IBI was initially developed to measure consideration and intent after ad exposure, you can also use it for awareness or performance goals.  Let’s dig into one example of the audience retargeting strategy using our hypothetical electric vehicle advertiser. This auto brand could include competitor electric vehicle brand keywords as part of their IBI strategy. Then, they could create audience segments based on users who are researching their competitors, and retarget those people as part of a conquesting strategy.  Here is how you can gather data on your potential audiences:  Your account manager at The Trade Desk can help you create the most effective keyword strategy. Generally, we recommend three categories of keywords:  Going back to our electric car example, that brand might choose the following keywords:  We also recommend blocking certain keywords to prevent false positives. For example, a fitness club advertiser that blocks “game,” “masterclass,” or “golf” to capture closer intent to the brand.  Please note that sensitive keywords are prohibited and include terms and advertisers related to tobacco, vape, CBD, cannabis, and gambling. Work with your representative at The Trade Desk to make sure your list of keywords is approved.  Inferred Brand Intent measurement with the Trade Desk can give you a more holistic view of your customers, access to actionable insights throughout the campaign, and the ability to target custom audiences that demonstrate intent to drive performance.  To learn more about measurement with Inferred Brand Intent, reach out to your account manager at The Trade Desk today.  ©2025 The Trade Desk. All rights reserved. Algarrobo town hall on the eastern Costa del Sol has voted to lower its IBI rates, (the tax paid by property owners to the town hall for local services), to compensate for the new rubbish tax which came into force across Spain on Thursday 10 April. The compulsory introduction of the rubbish tax in municipalities with more than 5,000 inhabitants continues to generate great political and social debate. Mayor of Algarrobo, Natacha Rivas, has announced that town hall "is already working on a lowering of the IBI in the municipality to try to compensate the residents of the rubbish tax imposed by the government of Pedro Sánchez in all the municipalities of Spain". She went on to explain that the town hall will apply a "package of discounts for both families and businesses". Rivas explained that, until now, the cost of rubbish collection and treatment was covered directly by the local councils, while Law 7/2022 obliges residents to pay for it from this April. "We still don't know the amount of the rebates, we have to see the impact of the modification of the rate and see the effect on the IBI," she told SUR. "The local councils and, above all, the residents lose," Rivas said in the statement, in which she claimed that this "imposition comes without dialogue or funding mechanisms for local councils". Comentar es una ventaja exclusiva para registrados Registered office Málaga, Avda. Dr. Marañón, 48. the leading global design & consultancy organization for natural and built assets is pleased to confirm it has completed its previously announced acquisition of Toronto based designing and building the resilient cities of tomorrow IBI is a technology-driven design firm with global architecture and technology expertise spanning more than 60 offices and 3,500+ professionals around the world Commenting on the completion of the IBI Group acquisition Global Chief Executive Officer at Arcadis said: we have reached a significant milestone for Arcadis IBI and our 33,000 employees across the world The coming together of our two companies is fundamentally about the growth of our businesses and opportunities for our clients and our people and crucially contributes to meeting the targets we set out in Arcadis’ 2020-2023 ‘Maximizing Impact’ business strategy we have a unique opportunity to grow our talent and expand to offer new and complementary client experiences both globally and in the growing Canadian and US markets.” For further information click here The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission All content on this site: Copyright © 2025 Elsevier B.V. and thank you for choosing CamposolToday.com to publicise your organisation’s info or event Camposol Today is a website set up by Murcia Today specifically for residents of the urbanisation in Southwest Murcia providing news and information on what’s happening in the local area which is the largest English-speaking expat area in the Region of Murcia When submitting text to be included on Camposol Today please abide by the following guidelines so we can upload your article as swiftly as possible: Send an email to editor@camposoltoday.com or contact@murciatoday.com Attach the information in a Word Document or Google Doc Also attach a photo to illustrate your article Marbella town hall is to put up its IBI property tax to ten per cent for owners of leisure and hospitality establishments a measure with which it aims to raise an extra 2.1 million euros in 2025 This is the first increase planned for the next fiscal year prior to the development of next year's budget and will be approved on Thursday 19 September in an extraordinary council meeting the measure will mainly affect hotel businesses The measure adds a fifth paragraph to Article eight of Marbella's regulatory tax bylaw which establishes a differentiated rate of taxation for urban properties with a "G hotel and catering" classification and takes the amount of 377,000 euros as the value threshold above which a new rate of one per cent will be applied reads the document issued by the Marbella's economic administrative court to 10 per cent of the properties in the municipality that have the highest cadastral value" before the next IBI property tax bill is due This measure is similar to the one approved in September 2023 which increased the IBI for commercial premises with a cadastral value of more than 1.5 million As the town hall spokesman Félix Romero explained at the time Marbella was facing "a judicial tsunami" following the Supreme Court's decision to increase from five to 15 years the statute of limitations period for legal cases brought against the town hall after the Gil party's term in office Former Michigan forward Ibi Watson is headed to Dayton.  Watson, a sophomore from Ohio, announced his plans to leave Michigan after two years shortly after the team returned from an appearance in the national championship game.  will have two years of eligibility remaining at Dayton he'll have to sit out next season before being able to finish up beginning with the 2019-20 campaign.  More: Michigan basketball's Ibi Watson will transfer to another college A former three-star prospect from the same high school that produced Caris LeVert Watson averaged 1.3 points per game in 19 appearance off the bench as a freshman in 2016-17.  Watson averaged 2.3 points in 5.6 minutes per game (24 appearances) during the Wolverines' 33-8 national runner-up campaign.  More: Michigan's Charles Matthews declares for NBA draft without hiring agent who declared for the NBA draft without an agent over the weekend.