Fundação de Amparo à Pesquisa do Estado de São Paulo image: Photo of the Human Skin Equivalent with Hypodermis (HSEH) developed by researchers at the Brazilian Biosciences National Laboratory Brazilian researchers have used three-dimensional (3D) printing to develop an artificial skin model with properties that are more similar to those of human skin called Human Skin Equivalent with Hypodermis (HSEH) could be used in studies to treat diseases and injuries such as wounds and burns as well as in the development of medicines and cosmetics without the need for animal testing. which ends on November 28th at the Faculty of Medicine of the Complutense University of Madrid (UCM) aims to strengthen links between researchers from the state of São Paulo and the European country “We were able to develop a complete skin model with three layers: the epidermis, dermis and hypodermis. In this way, we were able to obtain a model of the organ with characteristics very similar to those of a human being,” Ana Carolina Migliorini Figueira researcher at LNBio-CNPEM and coordinator of the project 3D skin models have been explored as an alternative method to using animals But the limitation of the options developed so far is that they neglect the hypodermis – the deepest layer of the skin which plays a fundamental role in regulating important biological processes such as hydration and cell differentiation influencing processes such as water regulation making it essential for creating complete and functional skin models With the support of FAPESP the researchers used tissue engineering techniques to improve the technology and succeed in building a full-thickness human skin equivalent with the hypodermis to create an environment closer to real human tissue “This new 3D skin model with the hypodermis layer provides a more accurate in vitro platform for disease modeling and toxicology studies,” concluded Figueira “The results of the tests we performed show that the hypodermis is essential for modulating the expression of a wide range of genes that are vital for skin functionality such as those related to tissue protection and regeneration,” she said The researchers used 3D bioprinting to build a skin model based on collagen which serves as a matrix for cell interaction LNBio will produce the skin for its own studies but will also be able to produce the material for partner research institutions The idea is to help develop grafts for treating wounds and burns Through a project also funded by FAPESP under an agreement with the Netherlands Organization for Scientific Research (NWO) the Brazilian researchers intend to use this more realistic 3D skin to develop a model of diabetic skin with chronic wounds and The idea is that the LNBio researchers will be able to vascularize the in vitro human skin model in three layers to create a version that mimics the skin characteristics of people with diabetes who may have wounds that are difficult to heal and are at risk of limb amputation a group of Dutch researchers affiliated with the Radboud University Medical Center is working to develop new biomaterials to create a dressing to treat diabetic wounds is to test it both in an animal model and on the human diabetic skin that we’ll develop,” Figueira explained a group of researchers from the Federal University of ABC (UFABC) intends to use synthetic biology tools to build biosensors based on genetic circuits to monitor the contamination of environmental samples By combining biological and engineering knowledge the researchers aim to introduce new functions in natural organisms by developing new genetic sequences “There are natural RNA and protein molecules that can interact with mercury and manganese The idea is to design these genetic circuits to monitor the contamination of water samples by these metals without the need to use robust and expensive equipment,” Milca Rachel da Costa Ribeiro Lins professor at UFABC and coordinator of the project The field of biotechnology is believed to be strategic for Spain and has received large investments from the UCM in recent years emphasized Spanish researchers who participated in the event “The United States remains the world leader in the biotechnology market Central America and the Middle East are showing very high growth One of them is that there are around 4,500 companies working in this field,” said Maria Isabel de la Riesco Biotechnology companies in Spain employ more researchers than other industries and salaries in the field are higher than the national average “Spain has a 2.46% share of the world's publications of biotechnology-related articles and their citation rate is 21% higher than the global average About 60% of the scientific production in biotechnology in the country is carried out in international collaboration,” stated Riesco The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships fellowships and grants to investigators linked with higher education and research institutions in the state of São Paulo FAPESP is aware that the very best research can only be done by working with the best researchers internationally it has established partnerships with funding agencies and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration 10.1038/s42003-024-07106-4 Unveiling the impact of hypodermis on gene expression for advancing bioprinted full-thickness 3D skin models are not responsible for the accuracy of news releases posted to EurekAlert by contributing institutions or for the use of any information through the EurekAlert system Copyright © 2025 by the American Association for the Advancement of Science (AAAS) the UCM students: everything blends with the typical neighborhood life and makes this area of the capital one of the best places to live On the hill of Príncipe Pío and separated by the Parque del Oeste is Argüelles, a neighborhood that belongs to the district of Moncloa-Aravaca, but that seems to be a part of Chamberí Argüelles is an expansion of the center of Madrid that took place at the end of the 19th century It is bounded on one side by the Plaza de España and on the other by the Air Force Headquarters architecturally reminiscent of El Escorial and many of the buildings in the northwest area of Madrid The barracks sits on the site of the former model prison which was the largest in Madrid during the 19th century The West Park occupies almost 100 hectares and in addition to improving the quality of life of those who enjoy it every day it makes the neighborhood and especially the blocks of buildings that look directly onto the tree-lined promenade one of the most expensive in the capital Brutalista is one of those newcomers to the neighborhood that already has good eating and drinking parishioners. The method is simple, crude, crude: you choose between three types of tasting menu(from 28 Its specialty: pickles and “everything with bones” (words of its chef and ideologist wine and partridges while we enjoyed the feast at the bar) From the last time we visited this temple of product cuisine and industrial concrete aesthetics we would like to recommend the smoked sardine El Lagar is a classic in the lists of bars with free tapas but it also has an important emotional factor: if you have studied in Madrid and you have not been to this bar It is usually crowded with college students who coexist with the usual parishioners and even with those who have it as a reference between bars to watch soccer is it possible to get to know someone through their recipe book? Frida Intima is proof that it is, and that it is a unique way to do so. Here you can taste the dishes that were cooked at the home of the Mexican artist, in that refuge that was the Red House. The clemachile (shrimp marinated in lime with a touch of tomato juice and celery), the cochinita sopes or the suadero taco with marrow are some of them, to which a careful cocktail bar is added. But there is more: Frida Íntima is also a free art gallery where you can find unpublished photographs donated by the artist’s family. Casa Paco has been, for almost 70 years, an icon of the Argüelles neighborhood and a hallmark of its identity. It is worth a visit if you are in the area. From here we recommend their omelettes (15 different flavors) or their croquettes of Iberian, boletus, cabrales, sirloin or oxtail. The narrow place has an open kitchen and its clientele is very varied and traditional. In addition, they also have a small terrace, which is usually full, so we recommend you to go early. View this post on Instagram The Fix has some of the must-haves for a great breakfast: freshly baked pastries, specialty coffee (toasted by them) a spicy and intense chai latte and an avocado toast that is hard not to order every time It also has a cave on the lower floor where you can work read and spend a quiet moment with the aroma of coffee if you are able to leave without one of the many books they sell with a special section of independent publishers the books and the light from the large window help you want to make Ad Hoc that third space that is neither your home nor work who gave it its name and who arranged the house as it is today so that the boomers, millennials and centenials can visit it today In it we can find more than 50,000 works of art including paintings life and aesthetics of the Spanish upper class of the time. An eclectic journey through the different rooms of the house that will bring us closer to styles such as classicism neo-baroque and rococo and is certainly worth a visit The palace of Liria is the private residence of the House of Alba one of the families with the most noble titles in Europe It is a neoclassical building by Ventura Rodríguez one of the most relevant and prolific architects in Madrid at the time it suffered several fires and the entire interior was lost although the great works of art it housed had already been placed in safekeeping among the British Embassy one of the most iconic monuments of Madrid and the Parque del Oeste has been in the capital since 1968 and was a gift from Egypt to Spain for its collaboration in the rescue of the Abu Simbel temples It is estimated that it was built between 185 BC and the first century AD is free and self-guided and can be visited from Tuesday to Sunday from 10 am to 8 pm one of the most emblematic places of this park is the Temple of Debod but in its extension of about 100 hectares has others such as the cable car an artificial stream or its famous rose garden that houses more than 600 species of roses it is said that from here you can see one of the most beautiful sunsets in Madrid is not uncommon to hear applause at some point during sunset near the Temple of Debod “During the early hours of yesterday morning a Nazi commando set fire to the Rafael Alberti bookstore in Madrid Despite the numerous threats and attacks to which the bookstore has been subjected there was no police protection at the time insurance companies do not want to take over bookstores.” This entry They wanted to burn down the Alberti bookstore to set ablaze the revolutionary thing that can exist within the pages of a book Today it continues to be a cultural reference in the neighborhood events… all for literature and creation It is a family flower shop that has passed from parents to children and it shows in the treatment the loyalty of the neighbors of the neighborhood and even in the prices since it is far from the franchises of flower shops where you get a kidney for a bouquet or a monstera that will die in three days even if you don’t want a bouquet of roses or an orchid you can stop by to see (and smell) the place if only to buy a 2 euro cactus or a hanging poto which survive the most extreme circumstances such as an unlit basement in the center of Madrid it’s not that they organize book signings or that they give you perfect advice if you’re looking for textbooks on film but that they also serve beer and coffee Coixet and even Fellini decorate the wall with their dedications giving a unique character to the singular bookstore It’s the ideal place to have a wine and chat about how much you love (or hate) Christopher Nolan or compete for who knows the most names of women nominated for Best Director Oscars after seeing a movie at the Golem you’ll probably get a bit of rage here and there but the Eight and a Half is a safe space for film buffs Building further on Amro's existing presence in Iberia they are also focused on an ambitious wider growth strategy across Europe Amro Partners has joined forces with Invesco Real Estate the $90bn global real estate investment business of Invesco Ltd to pursue opportunities in the Iberian residential market starting with the acquisition of two new projects in Spain The first project will comprise 400 new purpose-built student accommodation (PBSA) beds in northern Spain a 15-minute walk from one of the biggest and most renowned universities in the country the development will feature 166 beds in the Moncloa-Aravaca district close to several university campuses including Moncloa – the main university campus in Madrid both projects will target a full suite of the highest ESG credentials with a wide range of amenities and shared facilities encouraging student health and wellbeing “Invesco’s strong market presence and proven track record in the living space make them an ideal long-term partner as we strengthen our evolution into an institutional capital specialist asset manager “We are targeting off-market opportunities in well-connected locations within tier-one cities we are able to leverage our local expertise and sector experience to futureproof our investments and deliver excellent returns “We expect these to be the first of several transactions to be announced over the next few months.” Building further on Amro’s existing presence in Iberia and an actionable pipeline of 5,000+ student beds they are focused on an ambitious wider growth strategy across Europe including new markets in Germany The collaboration with Invesco in Iberia is a key pillar of this strategy organic growth to meet increasing demand for high quality Look out for your first newsletter in your inbox soon We help you navigate a myriad of possibilities Sign up for our newsletter for the best of the city By entering your email address you agree to our Terms of Use and 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Madrid An open-air night-time venue in Parque de la Bombilla for catching double bills of mainstream films during the Veranos de la Villa festival which takes place between July to September As well as the massive screen (with wayward sound) Fescinal also offers a smaller one for kids plus the opportunity to munch on bocadillos washed down with cerveza for that truly communal experience of movie-watching Thanks for subscribing! Look out for your first newsletter in your inbox soon! facebook twitter spotify tiktok About us Contact us Time Out Worldwide This list includes the city's public swimming pools and provides prices and practical information summer begins as soon as the solstice occurs; unofficially when the temperature warrants a full bath in a pool of water the public swimming pools (municipally owned and regionally owned) declared the swimming pool season started on Wednesday There are some differences between the municipal and regional ones: prices And in this article we recap what each one is and how to book them will be open until September 8 and their schedule is from 10am to 9pm Its price is somewhat cheaper (4.5€ the standard ticket) and it is also scalable depending on the circumstances of each person