Volume 7 - 2024 | https://doi.org/10.3389/fdata.2024.1422650 Time series data are recorded in various sectors the continuity of these data is often interrupted Several algorithms are used to impute the missing data and the performance of these methods is widely varied the effective imputation depends on the nature of missing and available data We conducted extensive studies using different types of time series data specifically heart rate data and power consumption data We generated the missing data for different time spans and imputed using different algorithms with binned data of different sizes The performance was evaluated using the root mean square error (RMSE) metric We observed a reduction in RMSE when using binned data compared to the entire dataset particularly in the case of the expectation–maximization (EM) algorithm We found that RMSE was reduced when using binned data for 1- with greater reduction observed for 15-min missing data We also observed the effect of data fluctuation We conclude that the usefulness of binned data depends precisely on the span of missing data and quantity of the missing and available data binned data can impute a wide variety of data including biological heart rate data derived from the Internet of Things (IoT) device smartwatch and non-biological data such as household power consumption data we extend our studies on the utilization of binned data for missing data of different time spans of univariate time series data collected from different sources We primarily used heart rate data derived from smartwatches worn by the healthy volunteers We synthetically made the missing data for 1- and 5-min time spans and then imputed the data using different algorithms The performance of imputation was quantified by using root mean square error (RMSE) as a metric we report on the circumstances that determine that binned data will provide better imputation compared to the imputation using the entire dataset sampling rate of the data are crucial factors We also report the role of data fluctuation using missing data from different time periods of day depending on whether the volunteers remain physically active or inactive We further extended our studies to non-physiological data We investigated the effectiveness of binned data in another time series data of power consumption heart rate data which are biological data and power consumption data and the second was publicly available data Heart rate data was collected as a part of the clinical trial NCT05106725 This is an IRB-approved non-interventional study and informed consent was collected from all subjects recruited in the trial The data were extracted from the wearable IoT device Fitbit Inspire 2 worn by four healthy male volunteers The volunteers wore their respective devices over the whole day we selected 30 random days for each volunteer having no missing data The heart rate data were available at 5-s intervals and converted to 1-min intervals after preprocessing The household electric power consumption database was downloaded from the UC Irvine Machine Learning (Hebrail and Berard, 2012) It is an energy consumption dataset for a house containing over 2 million measurements recorded at an interval of 1 min from December 2006 to November 2010 we used 1 month's (March 2007) data to evaluate the efficiency of using binned data for imputation We synthetically generated missing data by deleting data from days having complete data we imputed the missing data and compared the imputed data with the original data We used data for two different time frames of a day which we refer to as the “active period” and “inactive period.” The “inactive period” refers to 3–4 a.m when our volunteers were asleep and hence inactive The “active period” refers to 3–4 p.m when our volunteers were active in their different daily activities A similar time span was chosen for power consumption data too during the “inactive period,” the power usage was stable compared to the “active period.” The data from different days were binned into different sizes around the missing data period we used bins with bin sizes starting from 5 min In the case of power consumption data—while imputing 15-min missing data—we used bin sizes starting from 15 min RMSE calculates the disparity between the actual and imputed values providing a quantitative measure of the accuracy of our models in handling missing data during the “active period” of the volunteer Imputation of 5 min of missing heart rate data for volunteer V1 Variations in RMSE when data of different bin sizes were used for imputing missing data of “inactive” period of 3:22–3:27 a.m Variations in RMSE when data of different bin sizes were used for imputing missing data of “active” period of 3:22–3:27 p.m We observe the number of days RMSE reduced is more for 5-min missing data for all bin sizes Number of days RMSE reduced when data were used for different bin sizes for imputing 5-min missing data of “inactive” period of using (A) EM Number of days RMSE was reduced when data were used for different bin sizes for imputing 5-min missing data of “active” period using (F) EM we observe that the binned data are effective for imputing 5-min missing data of inactive period we do not find any optimal choice of bin size Number of days RMSE was reduced when data were used for different bin sizes for imputing 5-min missing data of “active” period of using (A) EM Number of days RMSE was reduced when data were used for different bin sizes for imputing 5-min missing data of “inactive” period using (F) EM As lifestyle follows some daily repetitive activities heart rate pattern also carries that profile for imputing missing data of a particular period of any day data from other days around the same time period are adequate the time span should be sufficient to carry the signature of the regularly repetitive work Reduction of time span also implies reduction of data points the sampling rate of the data is also crucial This is the reason that the binned data are more effective for imputation of missing data of a higher time span of 15 min compared to the 5 min and even lower 1-min missing data We conclude that the time span of missing data and sampling rate play a competitive role Box plot for fluctuation in 1 h binned data around 5-min missing data for the days when binned data worked and not worked using EM algorithm for (A) heart rate data and (B) power consumption data The use of binned data implies the use of data from a specific span. In other words, it uses censored time span data (Støvring and Kristiansen, 2011) It is advantageous as it uses less amount of data hence making faster imputation of real-time data possible As it considers data from a specified span the presence of noise and outliers beyond that span does not affect the imputation process The binning method is also applicable to a wide variety of imputation algorithms the major challenge of using binned data for imputing missing data occurs when data of missing periods deviate from the usual characteristics of the available data of similar time periods and the span of other days The activity of a person is reflected in his or her heart rate data If a person deviates from their routine activity for a particular day and if that data are missing the use of binned data may not be useful for imputation The technical challenge of using binned data includes generating binned data of optimal bin size Since time series data often carry personalized features the choice of bin size also needs to be personalized The so-called “active” and “inactive” periods may vary for different data sources We observed that using binned data provides better-imputed data for different types of time series data The advantage of the use of binned data includes the requirement of a lesser amount of data along with faster computation It can be integrated into big data analytics to fill the missing part It will help in the faster functioning of automated devices such as IoT devices Our extensive study shows that the usefulness of binned data is determined by the innate properties of the data which include the span of the missing period and the fluctuation within the available data the optimal bin size could not be defined because of the lesser effectiveness of binned data when the sampling rate is comparable to the missing data time span the current study will be helpful for time series data management across wide domains The raw data supporting the conclusions of this article will be made available by the authors Writing – review & editing The author(s) declare that no financial support was received for the research for his support in data acquisition and download The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fdata.2024.1422650/full#supplementary-material Missing data imputation of high-resolution temporal climate time series data Crossref Full Text | Google Scholar Comparison of missing data imputation methods in time series forecasting Crossref Full Text | Google Scholar Systematic review of using machine learning in imputing missing values Binned data provide better imputation of missing time series data from wearables “Handling missing data in the time-series data from wearables,” in Time Series Analysis - Recent Advances Google Scholar non-stationarity and the forecasting of monthly time series Crossref Full Text | Google Scholar Hebrail, G., and Berard, A. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Nupur Biswas, bnVwdXJAcmhlbml4Lm9yZw==; bnVwdXJiaXN3YXNAZ21haWwuY29t Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Metrics details We further compare our results with other records from the West/Central Mediterranean and West African region to discuss the similarities/differences between the identified paleoclimate periods from the penultimate glacial period to the Holocene and suggest the atmospheric-oceanic circulation mechanisms that may have caused the different humidity conditions. SnSiZer analysis developed on the Padul MAP reconstruction showing the statistically significant changes of the data for the last 200 kyr we show the raw MAP reconstruction with different Nadaraya-Watson smoothing levels (red-blue-yellow lines) along with the WMHPs and HSs reading from past to present (from right to left) the red and blue colors indicate the statistically significant precipitation increases and decreases The vertical axis represents the level of smoothing in logarithmic units and the horizontal red-blue-yellow lines the smoothing levels as in the upper panel Dark grey areas represent no significant changes and light grey areas represent where the sampling resolution is too low which is the oldest southernmost continental archive in the Iberian Peninsula (spanning the last ca Villarquemado is the unique northeastern Iberian lacustrine record covering the last 135 kyr The quantitative precipitation reconstruction from the fossil pollen data from Padul provides the mean annual winter and summer precipitation changes from southern Iberian Peninsula for the last ca being the longest continuous continental quantitative paleoclimate reconstruction from the western Mediterranean region The newly developed SnSiZer method was applied to identify the statistically significant precipitation changes as well as the relative magnitude of the humidity oscillations we identify six main WMHPs: WMHP-6 (180–155 kyr BP) WMHP-2 (27–18.5 kyr BP) and WMHP-1 (15.5–5 kyr BP) with the identified WMHPs and their comparison with West/Central Mediterranean and West African records both West/Central Mediterranean and West African climates are in phase with roughly coeval humid periods in both regions west Mediterranean and west African records are out of phase during low seasonality This could be explained by the westerlies and the influence of the local Mediterranean rainfall flux affecting the Mediterranean region providing moderate precipitation conditions (e.g. whereas West Africa was characterized by drier and even drought conditions cut the statistically significant increasing (red) or decreasing (blue) features it means that those changes are statistically relevant under that level of smoothing the scale-normalized derivatives used for the SnSiZer can be described as follows: Let \(K\) be the standard Gaussian density function and \({h}^{2}\) the variance Let us consider a continuous signal \(u(t)\) Then the convolution smooth \(L(t,{h}^{2})\) of \(u(t)\) is defined as: Smoothing reduces rough small-scale features revealing averaged features over longer and longer windows of \(t\) This means that \(\frac{\partial L\left(t,{h}^{2}\right)}{\partial t}\to 0\) as \(h\to \infty\) making the relative magnitudes of the derivatives useless as a measure of salience of a feature To ensure that the scale-normalized derivative remains bounded as the scale increases the smoothing method must be chosen so that the smooth tends to constant as the scale increases The mean annual, winter and summer precipitation results from Padul are freely available at the Pangaea data repository (https://doi.org/10.1594/PANGAEA.940006) Tierney, J. 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Open Arch. https://doi.org/10.1002/essoar.10506290.1 (2021) Download references This research is funded by the Academy of Finland (GRASS the Ministerio de Economía y Competitividad of Spain (projects CGL2013-47038-R the Junta de Andalucía FEDER (projects P-20-00059 and UGR-FEDER B-RNM-144-UGR18) and the research groups RNM-190 (Junta de Andalucía) and E02-20R (Gobierno de Aragón) acknowledges the funding received from the German Research Foundation–DFG–program (project FOR2358 "Mountain Exile Hypothesis") We also acknowledge all contributors of modern pollen samples in the Eurasian Modern Pollen Database Ramos-Román, Liisa Ilvonen & Heikki Seppä Jon Camuera & Antonio García-Alix Department of Stratigraphy and Paleontology Gonzalo Jiménez-Moreno & Antonio García-Alix Organismal and Evolutionary Biology Research Programme Faculty of Biological and Environmental Sciences Graciela Gil-Romera & Penélope González-Sampériz J.C performed the data processing and computation processes quantitative reconstructions and statistical analyses developed the new SnSizer extension and provided the modified code of the original SiZer to perform the analysis provided the pollen data from Villarquemado All the authors discussed the results and interpretations and contributed to the writing of the manuscript The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-022-12047-1 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing: Anthropocene newsletter — what matters in anthropocene research, free to your inbox weekly. The two 15-year-old students from San Jose National High School returned home on Saturday night after seeing the missing persons reports filed by their families. Jobert Padul and Trisha Jane Teodones were reported missing on September 28 when both teens failed to come home after their classes. Their parents filed police reports and alerted local media outlets when they were unable to contact them. In an interview with Palawan News, Arlene Teodones, the mother of Trisha, said that they returned on September 30 to the Padul residence in Brgy. San Manuel, where they were reunited with their parents and questioned by the police about their whereabouts. The teens had stayed in cottages near BM Beach but decided to return on Saturday after turning on their phones and seeing the messages and posts searching for both of them. They reportedly took a long commute from BM Beach and got lost in Brgy. San Jose before circling back to San Manuel, as they did not have experience in taking public transportation by themselves. Arlene was relieved upon learning of the teens’ safety, noting that the two were unharmed and feared the backlash from their noted absence. Arlene said that she was more disappointed by the vulgar comments found under the teens’ missing person’s posts on social media outlets. “Grabe po kasi yung mga comments nila, masakit sa dibdib yung mga nababasa ko. Sana hindi naman ganoon kasi mga minor naman ito, wala naman sa isip nila yung mga ganoong bagay,” Arlene said. She said that her, her husband, and Jobert’s parents were mostly worried about the two facing harassment from their peers once they return to school. The parties had agreed that for the benefit of their well-being, they will temporarily have modular classes instead of going to school. Arlene expressed her gratitude to the authorities who helped assist in bringing the two of them home. © Palawan News - All rights reserved 2025 | Oasis Media Group Corp. Designed and Developed by Neitiviti Studios, Inc. Enel Green Power Spain’s wind farms in Andalusia produced a total of 418 GWh in the first six months of 2017, corresponding to the annual consumption of the populations of Cordoba and Jaén together. Please enable JS and disable any ad blocker A painting and photo exhibit titled, "Ay Borongan!", featuring the highlights of the Padul-ong Festival of Borongan City, Eastern Samar formally opened Tuesday at the art gallery of the Globe Tower in Fort Bonifacio, Taguig City. {{gallery.imageDetails.images.0.description}} Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1105420 This article is part of the Research TopicPersonalized Immunotherapy: Advancing processes to extend patient collectivesView all 12 articles Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed in cancer cells These highly immunogenic antigens may trigger the immune system to combat cancer cells Improvements in sequencing technology and computational tools have resulted in several clinical trials of neoantigen vaccines on cancer patients we have looked into the design of the vaccines which are undergoing several clinical trials and challenges associated with the design of neoantigens We searched different databases to track the ongoing clinical trials and their reported outcomes the vaccines boost the immune system to combat the cancer cells while maintaining a reasonable margin of safety Detection of neoantigens has led to the development of several databases Adjuvants also play a catalytic role in improving the efficacy of the vaccine we can conclude that the efficacy of vaccines can make it a potential treatment across different types of cancers and even frameshift mutations in genes that may or may not be oncogenes or tumor suppressor genes they are more often used as neoantigen candidates Below we have discussed the reported outcomes in the neoantigen vaccine research Figure 1 Flow chart describing the article selection process for this review Each of these pipelines has its selection process and results in the lists of neopeptides these lists very often differ from each other we will discuss the generalized approach required for vaccine design The personalized neopeptide vaccine design requires information on the mutations in proteins which are translated from the mutation sites of the DNA in cancer cells This information is extracted by comparing the DNA sequences of normal and tumor cells Either whole genome sequencing (WGS) or whole exome sequencing (WES) data of DNA of both tumor and normal cells is required only exonic parts are only translated to peptides WES is sufficient to detect somatic mutations WES is more economical considering both clinical and computational costs the mutated proteins should be expressed in the tumor cells to ensure that mRNA sequencing of tumor cell mRNAs is also performed This post-processing includes the removal of duplicate reads which originate from the same fragment of the DNA Indel realignment is also recommended by realigning reads near detected indels to remove alignment artifacts the base quality score recalibration (BQSR) is performed using GATK the systematic errors made by the sequencer while calling the bases are estimated and base quality scores are calibrated accordingly These recalibrated BAM files are further used for identifying different genetic variants Figure 2 A schematic of the bioinformatics process of neoantigen vaccine design Frequently used software and tools are in red Since a vcf file may contain hundreds of mutations the associated information is used for prioritizing the possible neopeptides The mRNA expression strength and variant allele frequency are also considered for the final selection of peptides and helper peptides like tetanus are also used in the formulation The administration process includes subcutaneous and intravenous injections mostly in limbs The targeted somatic mutations should ideally be present in all cancer cells These can be founder mutations that initiated cancer and thus possibly may be present in all lineage cells that form the bulk of cancer tissue There may exist multiple subclonal mutations; consequently it may be better to target the dominant clone which may be present in the bulk of the cancer tissue Selection of clonal and subclonal mutations can be achieved by establishing cancer cell content in the tissue used for sequencing and comparing mutant allele frequency with wild type/normal allele frequency the variant allele frequency should be preferably up to 50% for the mutation to be considered for the vaccine target the maximum allele frequency will approach 1.0 should be compatible with the physiological environment the entire process should be cost-effective in terms of time We noted that there are many clinical trials currently ongoing and can be accessed via the NIH ClinicalTrials website (https://www.clinicaltrials.gov/ct2/home). The trials which involve the administration of vaccines on human subjects are listed and tabulated in Table 1 We observed that trials mostly involve multiple types of cancers and are also dedicated to specific sites like pancreatic cancer and breast cancer We provide a brief review of different cancer types covered by neoepitope/neoantigen clinical trials Table 1 List of clinical trials using neoantigen vaccine therapy The response of the vaccines also depends on the adjuvant drugs The ongoing trial NCT04161755 uses the drug atezolizumab along with mFOLFIRINOX in the context of pancreatic cancer patients undergoing neoantigen vaccine therapy Neoantigen vaccine therapy is being tried in breast cancer patients; specifically triple negative breast cancers (TNBC) where genetic instability is associated with a high mutational burden up to 25 neopeptides are going to be administered by the autologous dendritic cells over a 16 week span Another clinical trial NCT04879888 also uses peptide pulsed autologous dendritic cells at six doses on nine TNBC patients The clinical trial NCT03199040 is designed to evaluate the response of neoantigen vaccines in the presence and absence of the drug durvalumab in triple negative breast cancer patients is an ongoing phase 1 trial of a polyepitope DNA vaccine against triple negative breast cancer The immunogenicity and safety of the vaccine are being evaluated in the trial The anti-PDL1 antibody drug pembrolizumab is being assessed in the neoantigen vaccine trial NCT03568058 in NSCLC head and neck squamous cell carcinoma (HNSCC) classical Hodgkin lymphoma (cHL) and other solid tumors This study will observe the immune response when pembrolizumab is administered six weeks before vaccination Genocea Biosciences is also conducting a clinical trial (NCT03633110) on 24 participants having different cancers This trial also uses the drug pembrolizumab along with nivolumab to evaluate the efficacy of vaccine therapy NCT3300843 was also initiated for pan-cancer study using peptide loaded dendritic cell vaccines but was terminated due to low accrual Individualized VB10.NEO vaccine and bempegaldesleukin (NKTR-214) are being used in the clinical trial NCT03548467 for patients at the metastatic stage It plans for 14 vaccinations for each of the 65 patients and bempegaldesleukin (NKTR-214) will be given after at least four doses of vaccinations The primary goal is to measure the safety and adverse effects of the vaccine Secondary outcome measurement includes measuring immunogenicity by T cell activity to each neoepitope Similar to the trial NCT04161755, clinical trial NCT03359239 aims to determine the effects of atezolizumab in combination with a personalized cancer vaccine, PGV001 (84) for locally advanced or metastatic urothelial cancer patients A clinical trial is also evaluating the immune response of a shared antigen vaccine PROSTVAC and tumor specific antigens generated DNA vaccine with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) for checkpoint blockade (NCT03532217) The ongoing open label phase 1a/1b clinical trial (NCT03970382) is focusing to evaluate the efficacy and safety of NeoTCR-P1 T cells in subjects with metastatic hormone-sensitive prostate cancer NCT03040791 is another trial involving pancreatic cancer patients which also utilizes nivolumab to explore DNA repair defects (DRD) mainly in the Homologous Recombination (HR) pathway The effect of nivolumab is also being investigated with or without ipilimumab in female patients suffering epithelial ovarian or fallopian tube cancer in clinical trial NCT02498600 The outcomes will be measured as per response evaluation criteria in solid tumors and incidence of adverse events in advanced stages of the disease Clinical trial NCT04455503 also treats advanced melanoma patients but with two types of EVX-02 vaccines with nivolumab in two cohorts Depending on the study results the third cohort will receive either one of the two types of EVX-02 vaccine This study will measure safety and tolerability by measuring vital signs like heart rate Neoepitope-specific T cells will be monitored by ELISPOT Other pharmacodynamic responses of EVX-02 will be assessed by MHC I multimer analyses detecting neoepitope-recognizing CD8+ T cells and by flow cytometry to detect vaccine induced intracellular cytokine response Relapse free survival period will be measured as secondary outcomes A trial (NCT03422094) based on neoantigen vaccine therapy on glioblastoma patients was initiated but later focus was changed to cell therapy Clinical trial NCT02510950 targeting glioblastoma patients did not proceed due to financial limitations We observed variations in the vaccine formulation and administration strategies followed by different trials The number of chosen peptides varied from 5 - 20 depending on the mutational burden These peptides are often applied with adjuvants Poly-ICLC is used as an adjuvant in multiple trials Poly-ICLC stimulates the release of cytokines and the production of interferon-gamma The administration process and doses also vary and subcutaneous injections at limb organs are used for administration The dose typically remains around 100μg per peptide The treatment typically continues for several months Table 1 lists different formulation and administration strategies observed in the trials we observe that the clinical trials employing neoantigens are showing promising results in terms of immunogenicity and safety on-time delivery of these personalized vaccines to patients remains a challenge These databases help to find neopeptides whenever a mutation is detected the proper selection of adjuvant drugs at appropriate doses and times plays a crucial role in the success of neoantigen immunotherapy We observe that the neoantigen vaccines appear safe with limited side effects the survival period is still not promising This may be a result of the majority of the trials currently ongoing are conducted on patients who have already reached the metastatic stage or the late stage of the disease An early intervention with neoantigen vaccines may provide a longer survival period for the patients It needs to be validated by clinical trials in the future It makes neoantigens specific to the tumor stage and more trials are needed for exploring patients of different stages As mentioned in the introductions section and based on the NIH clinical trial website we noted several clinical trials that are about to initiated The results from those studies will provide a better landscape on the therapeutic efficacy of neoantigen immunotherapy we conclude neoantigen vaccines are capable of exhibiting tumor-specific immunogenicity in different types of solid tumors They leverage CD4+ and CD8+ effector T cells across cancer types there is an enormous requirement for improvements in several aspects like the optimized design of neoantigens to ensure the efficacy of the vaccine Conducting ex vivo studies on 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Nupur Biswas, bnVwdXJAcmhlbml4Lm9yZw==; bnVwdXJiaXN3YXNAZ21haWwuY29t The Municipal Economic Enterprise and Development Officers (MEEDO) in Palawan formalized their league today Their organization is now known as the Palawan League of Local Economic Enterprise and Development Officers The Provincial Information Office (PIO) said the newly elected officials of the association took place this morning at the Governor’s Office in the provincial capitol building Narra MEEDO Albert Felizarte was elected as the president of PLLEEDO San Vicente MEEDO Edgar Adante was elected as the vice president for the northern part of the province Nelson Avanceña was elected as the vice president for the southern region – Vice President for the South: Engr The mentioned officials will serve for a term of three years Vice Governor Ola immediately provided an initial fund of ₱10,000 PEEDO Officer-in-Charge Richieross Isidro Austria said the initiative is in line with the directive and vision of Governor Dennis Socrates is a milestone in the field of Local Economic Enterprise in the Province of Palawan will surely enhance the collaboration and mutual support among MEEDO’s with the end view of strengthening the various economic enterprise managed by every municipality throughout the province,” said Austria He said establishing the organization is crucial to further strengthen the economic enterprises across the province as these contribute significantly to the government’s ability to provide quality services to the people of Palawan © Palawan News - All rights reserved 2025 | Oasis Media Group Corp Designed and Developed by Neitiviti Studios is known as the Ruta del Sol after the Vuelta a Andalucia stopped in the mid-1970s the Vuelta a Andalucia re-started in 1986 and simultaneously it adopted the name Ruta del Sol The Ruta del Sol was until 1986 a separate race which had been running since 1978 and which up until Andalucia’s organisers acquisition of the title rights had covered the neighbouring regions of Valencia and Murcia as well the routes of the Vuelta a Andalucia-Ruta del Sol remain solely within the region of Andalucia Stage 1: Almonaster la Real - Sevilla 165.2kms Stage 2: Palomares del Rio - Cordoba 186.3kms Stage 4: Alhaurin de la Torre (individual time trial) 21kilometres Stage 5: San Roque - Peñas Blancas 164.2 kilometes The Bureau of Internal Revenue (BIR) recognized the Puerto Princesa City government as one of the top taxpayers among local government units for the year 2023 The plaque of recognition was received on March 15 by City Treasurer Jerome Padrones and City Accountant Charlito Padul from BIR District Office No The BIR acknowledged the Puerto Princesa City government under the leadership of Mayor Lucilo Bayron for its ongoing partnership through the “prompt and efficient payment of correct taxes,” which contributed to achieving the district collection goal last year Padrones explained in a statement released by the City Information Office that these taxes come from deductions in the salaries of regular Padul and Padrones presented the plaque to Bayron on Monday Sign in to listen to groundbreaking journalism Philippines – The Department of Justice’s (DOJ) panel of prosecutors upheld the junking of a complaint against police accused of killing an activist couple during “Bloody Sunday” operations in March 2021 the prosecutors junked the motion for reconsideration against the resolution that dismissed the murder complaint against cops tagged in the killing The motion, dated May 2, 2023, was filed by Rosenda Lemita, mother of Ana Mariz “Chai” Lemita-Evangelista, and Ariel Evangelista’s mother-in-law. Lemita’s motion came after the prosecutors junked the complaint against the cops in March this year due to insufficiency of evidence NEWS UPDATE: DOJ affirms the dismissal of the case against cops accused of killing an activist couple during Bloody Sunday operations in Batangas in 2021. @rapplerdotcom pic.twitter.com/q5e92FqeQg the panel of prosecutors said the motion for reconsideration did not show any argument that will push for the reversal of the DOJ’s earlier decision “The complaint did not sufficiently prove conspiracy but merely relied on a baseless assumption that the Philippine National Police (PNP) conducted its operations specifically to kill spouses Evangelista Complainant only alleges that ‘Spouses Evangelista were targeted pursuant to a virtual kill list under COPLAN ASVAL,” the resolution read adding that no evidence was submitted to support the claim The prosecutors said that the police’s pre-operation briefing where the execution of warrants had been planned supported the “legitimacy of the police operation to implement the search warrants and not simply a conspiracy to kill spouses Evangelista.” the complainant failed to establish who actually killed the couple What was only proven were the bullets recovered from the couple’s bodies but the ownership of the bullets was not identified “The findings of the panel are consistent with the pieces of evidence at hand posited by complainant Lemita in her Motion for Rèconsideration cannot be taken against respondents,” the prosecutors added On March 7, 2021, nine activists were killed by the police during their simultaneous operations in Southern Luzon – including on the Evangelista couple. At least six activists were also arrested by the authorities during the operations. (READ: Leaders lost: The 9 activists killed by Duterte gov’t on ‘Bloody Sunday’) Honoring the Virgin Mary and the Padul-ong Festival of Borongan, Eastern Samar, Binibining 28, Gabrielle Basiano appeared like a living painting of the Blessed Mother in her national costume. It is a mythical presentation of how the image of the Blessed Virgin Mary was mysteriously transported from Borongan to Portugal. The aforementioned costume was designed by Kevin Batino and Jevin Salaysay. A post shared by Ken Batino (@kenbatino) The photo is among the 39 other national costumes that showcase the uniqueness and creativity of the candidates with the help of local fashion creatives. It is being exhibited in a 7-feet-tall installation at the Farmers Plaza from July 4 until July 15, and will be moved to Gateway Mall from July 16 until the grand coronation night. The display presents the images shot by Saldaña and Owen Reyes at Las Casas Filipinas de Acuzar in Quezon City, with the ladies styled by Patrick Henry Mergano and Macky Combe. Just like in the glam shot photo exhibit, Araneta City will soon power each national costume photo with augmented reality (AR) technology to bring the portraits to life. Exhibit viewers simply need to download the UniteAR app on their smartphones, open the AR camera on the app, and scan the QR code on any of the panels to see the Binibini in motion as they rock their national costumes. The national costume fashion show of Binibining Pilipinas 2022 will be held at the New Frontier Theater on July 16, 3 PM. And tickets are available on ticketnetonline. A post shared by Binibining Pilipinas (@bbpilipinasofficial) Gabrielle Basiano is a 27-year-old stunner and was the Bb She won the Best in Long Gown award with her Perla gown where she served Cher realness with the hood detail which caught the attention of the netizens she vies to win one of the Binibining Pilipinas crowns Source: https://www.instagram.com/kenbatino/ https://www.instagram.com/bbpilipinasofficial/ https://www.facebook.com/bbpilipinasofficial/ PAGEONE Magazine provides a captivating blend of news and lifestyle offering readers a window into the pulse of today's society From in-depth analyses of current events to inspiring profiles of individuals shaping the future we curate content that both informs and entertains Learn how to describe the purpose of the image (opens in a new tab) Leave empty if the image is purely decorative