Cepsa will supply 100% renewable electricity to these facilities IONITY has launched its first high-power charging station in Spain the new site is equipped with 4 high power charging points each with a capacity of 350 kW These chargers are compatible with the European standard Combined Charging System (CCS) and reduce charging times for current and future EVs significantly Offering 1,2 Mega Watt of power for the 4 high power chargers the IONITY station is among the fastest in Spain IONITY has prepared the station for 2 additional high-power chargers that can be added depending on the demand Cepsa will supply 100% renewable energy to these facilities This first station in Spain is the latest chapter in the expansion of IONITY’s pan-European charging network The objective is to make long distance EV travel a reality Pallejà is also one of 340 ultra-fast charging stations being deployed within the Europe-E project covering main routes across 13 EU Member States and along all 9 TEN-T Core Network Corridors and the Core Network The EUROP-E project is co-financed by the Connecting Europe Facility of the European Union In July 2018, Cepsa signed a collaboration agreement with IONITY the European high-performance charging network formed by the BMW Group for the installation of electric charging points at its service stations in Spain and Portugal Cepsa currently has an extensive network of close to 1,800 service stations in Spain and Portugal The Cepsa management team is focused on offering a clear model of customer orientation Cepsa sells top quality fuels at its Service Stations and also offers many other products and services If you have done all of this and still can't find the email Metrics details gut microorganisms harbour and exchange antibiotics resistance genes Using shotgun sequencing-based metagenomics we analysed the partial eradication and subsequent regrowth of the gut microbiota in 12 healthy men over a 6-month period following a 4-day intervention with a cocktail of 3 last-resort antibiotics: meropenem Initial changes included blooms of enterobacteria and other pathobionts such as Enterococcus faecalis and Fusobacterium nucleatum and the depletion of Bifidobacterium species and butyrate producers The gut microbiota of the subjects recovered to near-baseline composition within 1.5 months which were present in all subjects before the treatment remained undetectable in most of the subjects after 180 days Species that harbour β-lactam resistance genes were positively selected for during and after the intervention Harbouring glycopeptide or aminoglycoside resistance genes increased the odds of de novo colonization the former also decreased the odds of survival Compositional changes under antibiotic intervention in vivo matched results from in vitro susceptibility tests Despite a mild yet long-lasting imprint following antibiotics exposure the gut microbiota of healthy young adults are resilient to a short-term broad-spectrum antibiotics intervention and their antibiotics resistance gene carriage modulates their recovery processes Prices may be subject to local taxes which are calculated during checkout The high-quality reads have been deposited in the European Nucleotide Archive with accession number ERP022986. Relative abundances of taxa and functional features can be downloaded at http://arumugamlab.sund.ku.dk/SuppData/Palleja_et_al_2018_ABX/ The human intestinal microbiome in health and disease Comparative metagenomic study of alterations to the intestinal microbiota and risk of nosocomial Clostridum difficile-associated disease An obesity-associated gut microbiome with increased capacity for energy harvest Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota Gut metagenome in European women with normal A metagenome-wide association study of gut microbiota in type 2 diabetes Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn’s disease Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders Consensus report: faecal microbiota transfer—clinical applications and procedures Towards a more comprehensive concept for prebiotics Effects of probiotics on gut microbiota: 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human normal intestinal microbiota using culture and pyrosequencing methods Same exposure but two radically different responses to antibiotics: resilience of the salivary microbiome versus long-term microbial shifts in feces Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial Microbial diversity in individuals and their household contacts following typical antibiotic courses The initial state of the human gut microbiome determines its reshaping by antibiotics Selective decontamination of the oropharynx and the digestive tract and antimicrobial resistance: a 4 year ecological study in 38 intensive care units in the Netherlands Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes Metagenomic species profiling using universal phylogenetic marker genes function and diversity of the healthy human microbiome Temporal and technical variability of human gut metagenomes Updates on the sporulation process in Clostridium species Extensive impact of non-antibiotic drugs on human gut bacteria An integrated catalog of reference genes in the human gut microbiome CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology Carbapenemases: the versatile β-lactamases Acquired vancomycin resistance in clinically relevant pathogens a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii Study of the correlation of imipenem resistance with efflux pumps AdeABC AdeDE and AbeM in clinical isolates of Acinetobacter baumannii knowledge and principle: back to metabolism in KEGG Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells Gut inflammation provides a respiratory electron acceptor for Salmonella Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella Precision editing of the gut microbiota ameliorates colitis Integration and visualization of host-pathogen data related to infectious diseases Bacterial quorum sensing: its role in virulence and possibilities for its control Microbiota-mediated colonization resistance against intestinal pathogens Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis Gastrointestinal microflora studies in late-onset autism Real-time PCR quantitation of Clostridia in feces of autistic children Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder Intestinal microbial variation may predict early acute rejection after liver transplantation in rats Richness of human gut microbiome correlates with metabolic markers Systemic absorption of oral vancomycin in patients with Clostridium difficile infection Absorption of oral aminoglycosides following bone marrow transplantation MOCAT: a metagenomics assembly and gene prediction toolkit A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia Fast and accurate short read alignment with Burrows-Wheeler transform Search and clustering orders of magnitude faster than BLAST Proportionality: a valid alternative to correlation for relative data Normalization and microbial differential abundance strategies depend upon data characteristics The statistical analysis of compositional data Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota Download references This work was funded by an international alliance grant from The Novo Nordisk Foundation Center for Basic Metabolic Research which is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (grant no Our work was also funded by the TARGET research initiative (Danish Strategic Research Council [0603–00484B]) the Danish Diabetes Academy supported by the Novo Nordisk Foundation the Danish Council for Independent Research (Medical Sciences) was funded by FP7 METACARDIS HEALTH-F4-2012-305312 These authors contributed equally: Albert Palleja Novo Nordisk Foundation Center for Basic Metabolic Research Charité-Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine Max Delbruck Center for Molecular Medicine in the Helmholtz Association Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health University of Heidelberg and European Molecular Biology Laboratory Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology participated in the protocol design and application and in the participant recruitment and selection performed sample collections and carried out patient phenotyping performed shotgun metagenomics sequencing and taxonomic profiling All authors contributed to data interpretation All authors read and approved the final manuscript The authors declare no competing interests Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations legends for Supplementary Tables and Supplementary Datasets Comparison between taxa and KEGG function abundances at baseline (D0) and at subsequent time points (D8 D180) using a two-sided Wilcoxon signed-rank test Sample information and read quality control statistics Predicted and manually curated gene assignments (taken from GenBank) for 3 well-characterized species such as Salmonella typhimurium Species that differentially changed their abundance (two-sided Wilcoxon signed-rank test) following antibiotic treatment (from Supplementary Table 1) contrasted with their extent of relative growth inhibition from Maier et al.38 Extent of enrichment (significantly higher number of genes) of ARGs for the drugs used in this study (and multidrug efflux pumps) in species enriched under intervention versus not (from Supplementary Table 1) Gene-level differentially abundant ARGs under intervention relative to their significantly differential prevalence in genomes in enriched versus depleted species among those differentially abundant under intervention (from Supplementary Table 1) Associated data for Supplementary Figure 6 Download citation DOI: https://doi.org/10.1038/s41564-018-0257-9 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Nature Reviews Gastroenterology & Hepatology (2025) Sign up for the Nature Briefing newsletter — what matters in science This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Archive Architecture Checkers and Rally's has opened a corporate unit in Orlando at 10793 South John Young Parkway "The Orlando location stands as a testament to the brand's enduring ambition," Alvaro de Palleja chief restaurant officer at Checkers Drive in Restaurants "Checkers and Rally's model has proven itself in the QSR and drive-thru space and we are well-versed in the operations involved We're eager to bring this new prototype to the Orlando market providing more opportunities for job creation and business growth to the area." The location features an updated prototype marking the brand's first corporate store with the new look "We view this opening as a reiteration of our unwavering commitment to growth and progress," Kris McDonald VP of development at Checkers and Rally's Drive in Restaurants "This expansion marks a pivotal step forward in our brand's strategic development plan community engagement and culinary excellence the new restaurant promises to elevate the taste preferences of Orlando residents and visitors alike Checkers and Rally's brings aggressive plans to develop and grow our presence in Florida." Checkers and Rally's merged in 1999 to form one concept The brand is targeting markets in Wisconsin Get the latest news and resources from QSR Web often boosting the capacities of thousands of people taking on the role of modern landmarks alongside stadiums there are small-scale multi-purpose sports halls or present in rural areas with limited access to other public amenities these venues embrace and expand their multi-purpose role by offering opportunities to play Arena do Morro - Herzog & de Meuron. Image © Iwan BaanIn many rural and suburban areas, these halls are the largest interior spaces publicly available. From sports competitions and physical education classes to community fairs and town meetings, these spaces show versatility, accommodating a wide range of activities on a daily basis. With a relatively simple architectural image, they fulfill a complex and noble social function as an active and representative public building. Arena do Morro - Herzog & de Meuron. Image © Iwan BaanDesigning such venues involves negotiating between limited resources and the need to create a representative image The same duality is reflected in the urban aspect of such halls: while their volume and dimensions stand in contrast to the surrounding urban fabric Their representational role requires careful urban integration ensuring accessibility for the entire community Related Article Architecture Beyond Humanity: Designing for Non-Human Species Kura Kura Badminton Courts - IBUKU + Studio Jencquel. Image © Tommaso RivaTo further strengthen the community's connection to the space, local resources, and vernacular craftsmanship can be integrated into the design of these facilities, preserving the area's cultural heritage. Through all of these combined elements, sports halls hold the ability to reflect and solidify a community's identity and sense of place, anchoring a wide variety of social activities. 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