The funds will support the company’s R&D including setting up machinery to kick off a phase zero study in early 2025 and a second-stage clinical trial in the future including expanding the company's infrastructure and its Salt Lake City-based team are male reproductive urologists who are actively working with Bradley Cairns one of the world’s leading experts in chromatin and sperm biology a professor and researcher at the University of Utah “There have been very few and very limited efficacy treatment options for men and their fertility problems when I see a man in a clinic with fertility problems there are only two things I can offer him: medicine which has literally a flip-of-a-coin chance of helping him solve his problem or surgery In the context of where we are technologically Pastuszak and his colleagues have laid the foundation for male fertility solutions by understanding at a molecular level what spermatogenesis looks like The company dissected the ‘programming’ for turning a stem cell into a sperm cell the Pastuszak and his team have turned this knowledge into a company that they named Paterna BioSciences "We have reached the milestone of generating gametes that have completed all the cellular processes of DNA and maturing so that they can be used for fertilization,” said Dr “They are one step away from looking like a sperm cell,” Dr “We are probably a few months away; to be perfectly candid We are starting talks with the FDA and setting up the clinical development process for our clinical trials The University of Utah faculty is also collaborating with us and we do a tremendous amount of work with them as both my co-founders and I are faculty there Gametes are reproductive cells (eggs in females sperm in males) that combine during fertilization Spermatogenesis is the process of sperm cell development in the testes Pastuszak and his team plan to run two studies The first is a phase zero study to take place in 2025 which the company will test the ability of gametes to fertilize human eggs in vitro which will be in vitro fertilization (IVF) using Paterna's gametes and transferring those embryos identically to the IVF process Such a process would solve the big issue highlighted by Pastuszak the selection of male gametes is very subjective and done by an embryologist sitting under a microscope “Where we have an advantage is that we are looking at the entire process and we can do an extensive array of testing on those gametes to exclude those with genetic defects that could impact fertilization essentially pre-qualifying these cells before we ever hand them off to the IVF clinic Our internal slogan is we create gametes that we can stand behind I want to be able to look my patients in the eye and tell them I can help,” exclaimed Dr Pastuszak has worked closely with Springtide Ventures a key investor and supporter of biotechnology and healthcare innovation Known for previous investment in companies like PathologyWatch Springtide backs groundbreaking advances that improve patient care a state-sponsored agency with a mission to support and fund promising startups also contributed to the funds raised by Paterna BioSciences See previous TechBuzz coverage of the origin and mission of Utah Innovation Fund. Shining a spotlight on Utah's tech and startup community NORTHWOOD - The Exeter High School girls track team won two events and placed first at the 24-team Black Bear Invitational Saturday at Coe-Brown High School Junior Martelle McBride won the long jump (16 feet 6.5 inches) and the 4x400-meter relay team Oyster River (66) and Coe-Brown (56) placed second and third McBride also placed third in the 100 (13.29) while junior Lucille Beem was second in the discus (101-11) and third in the shot put (31-01.5) Other top-three finishes for Exeter included Poteet (400 Molly Flynn was second in the triple jump (33.3.75) Carolyn Milks was fifth in both the 100 (13.37) and 200 (27.72) Sienna Metcalf was fourth in the 400 (1:02.29) and Emmie Wentworth was sixth in the discus (88.4) placed first in a time of 3:39.12 at the 18-team Black Bear Invitational at Coe-Brown High School while Phillips Exeter Academy (52) and Coe-Brown (45) placed second and third Dover's Melo Berdecia won the 800 (1:58.19) Exeter's Daniel Batstone was second in the 200 (23.26) and Dover's Connor Lazarz was fifth in the discus (127-7) Josh Kelly won the 110 high hurdles (15.92) Nolan Peters was fourth in the 3,200 (9:51.54) and Luke Boynton was sixth in the 300 hurdles (44.90) Maine - Jackson Greene had three goals and two assists and Marshall Lasewicz had three goals and one assist for York Pat Hathaway and Tyler Bland both had one goal and one assist for the Wildcats KINGSTON - Both the Exeter High School boys and girls track teams set meet records in the 29-team Sanborn Invitational on Saturday placed first in a record-setting time of 4 minutes The following Exeter girls won their respective events - Paterna (1,600 and Bri Paterna was third in the 3,200 (11:40.29) Exeter swept the top three placements in the boys 400 with Brodie Proulx placing first (51.64) and Griffith (51.69) and Manix (52.31) placing second and third Other top-three finishes were turned in by Logen Poteet in the 3,200 (second and Thomas Eastwood in the pole vault (second Maine - Senior Sophia Luchette had four goals and one assist for York in this Class B win Ava Fontaine added two goals and one assist for the Wildcats Natalie Dickson and Ella Neiverth all had one goal and one assist York freshman goalie Piper Schambach had 11 saves Paterna BioSciences UT-based biotechnology company dedicated to solving male infertility The company intends to use the funds to accelerate the development of its in vitro spermatogenesis (IVS) technology through preclinical development Paterna BioSciences is focused on solving male infertility through innovative approaches for in vitro spermatogenesis (IVS) a novel treatment by growing healthy sperm in a laboratory from the male’s own cells It aims to improve human reproductive health by partnering with in vitro fertilization (IVF) clinics to enhance success rates engaging men in optimizing their reproductive health and expanding the treatment options for IVF Paterna expects to enter early-phase studies in 2025 and will bring its male fertility solution to market after FDA approval 29/10/2024 Writing by David Latona; Editing by Alison Williams Our Standards: The Thomson Reuters Trust Principles., opens new tab , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved ASU MedTech Accelerator welcome newest cohort Participants of the 2023 MedTech Accelerator program demonstrate their company's noninvasive highly accurate cardiac pressure measuring and monitoring device on a grad student as MedTech Accelerator Director Rick Hall (far left) and Dr medical director for Mayo Clinic’s Discovery Oasis and co-founder and chief medical officer of the MedTech Accelerator (second from left) The 10 companies participating in the 2025 Mayo Clinic and ASU MedTech Accelerator program hail from five different nations and are the first cohort to have representation from life science companies The accelerator provides emerging companies with a multiday immersive curriculum in health care entrepreneurship including: lectures and workshops with world-class scientific and engineering experts; resources to navigate regulatory pathways; and tools for product commercialization and customer acquisition business development and networking events "Arizona is recognized for its rich environment of innovation and entrepreneurship, and with this year’s cohort, we have yet another international group of innovative founders that are bringing novel approaches to very real health care problems. We anticipate the accelerator to be a launching point for many of these companies to continue working in and around our organizations by capitalizing on our joint strengths,” said Rick Hall After the two-week curriculum portion of the program the cohort will remain a part of the MedTech Accelerator support network allowing continued collaboration and guidance medical director for Mayo Clinic’s Discovery Oasis and co-founder and chief medical officer of the MedTech Accelerator From liquid biopsies to male infertility to menopause this year’s participating companies represent a wide range of innovative health care solutions: HealthTech Connex HealthTech Connex is bridging the gap between research and real-world applications in advanced brain care With clinical neuroscience and brain vitality as a premier focus they aim to connect science and R&D to product breakthroughs providing translational neuroscience innovations to care sectors and communities worldwide Learn more about the Accelerator at medtechaccel.com A technology created at Arizona State University is helping doctors and their patients overcome challenges in weight loss.By 2035 over 1.5 billion people globally will have obesity Emlyn Pratt’s undergraduate journey at Arizona State University included a psychology degree the completion of two certificates and various extracurricular activities — and they are just… Quick: Describe “coefficient of friction.” You have 250 milliseconds.That fraction of a second is the average reaction time it takes to sort out what our brain is telling us and react to it.… "From Paterna to Mestalla" is a living mural constantly evolving and expanding its records each season the Ciutat Esportiva of Valencia CF celebrates 33 years since its official inauguration in 1992 a total of 122 players have made their official debut with the first team after previously playing for VCF Mestalla The latest six players to achieve this milestone in the 2024/25 season are Martín Tejón They have now earned their place on the mural joining legendary names in the club's history such as their coach Miguel Ángel Angulo it’s a great honor to be on this list alongside such amazing players,” says Martín Tejón who was the first to make his debut this 2024/25 season He recalls how he got goosebumps when stepping onto Mestalla after spending more than a decade at the VCF Academy "Making my debut with the first team is something huge for any player there are incredible players we’ve watched on TV who are spectacular I hope to be like them one day," says Pablo López the most recent debutant to join the "De Paterna a Mestalla" mural this season In the minds of these six VCF Mestalla players—and in those of all the VCF Academy players who see the mural every day on their way to training—is the dream of following in the footsteps of the current first-team players who also emerged from VCF Mestalla and the Ciutat Esportiva of Valencia CF la academia vcf, la cuarta mejor de europa Instagram: @academiavalenciacf Related news Ver todas Check out all the activities scheduled for this month Valencia CF secures its presence in Seattle until 2028 through its VCF Academy Latest news Ver todas The pitch has been restored thanks to donations from LALIGA EA SPORTS, Divina Seguros, and contributions to the ‘FILA CERO SOLIDARIA’ Volume 10 - 2022 | https://doi.org/10.3389/fbioe.2022.836747 Extracellular vesicles (EVs) play a crucial role as potent signal transducers among cells with the potential to operate cross-species and cross-kingdom communication Nanoalgosomes are a subtype of EVs recently identified and isolated from microalgae Microalgae represent a natural bioresource with the capacity to produce several secondary metabolites with a broad range of biological activities and commercial applications The present study highlights the upstream and downstream processes required for the scalable production of nanoalgosomes from cultures of the marine microalgae Tetraselmis chuii and conditions were assessed to improve EVs isolation by tangential flow filtration (TFF) The optimization of the overall bioprocess was enhanced by quality control checks operated through robust biophysical and biochemical characterizations we showed the possibility of recycling by TFF microalgae cells post-EVs isolation for multiple EV production cycles The present results highlight the potential of nanoalgosome production as a scalable cost-effective bioprocess suitable for diverse scientific and industrial exploitations we demonstrate the possibility to recycle microalgal biomass after EVs harvesting to renew the cell culture and continue EVs production in a cyclic bioprocess (renewable processing) This capability to go through several production/isolation cycles further increases the interest of microalgae as a sustainable and renewable biosources of EVs The KrosFlo® KR2i TFF System from Repligen (Spectrum Labs USA) was used to isolate microalgae-derived EVs Microalgae cultures (1.6 L) were clarified by sequential micro- and ultra-filtration using TFF hollow fiber filters (MiniKros Sampler) with cut-off of 650 nm (S04-E65U-07-N Three different settings were evaluated: feed flow 750 ml/min and permeate flow 60 ml/min feed flow 450 ml/min and permeate flow 6 ml/min and feed flow 450 ml/min and permeate flow 6 ml/min followed by a wash of the TFF cartridges with 100 ml of culture medium During all filtration processes transmembrane pressure (TMP) was kept constant at 0.02 bar The small and large EVs recovered from the retentate of the 500-kDa and 200 nm cut-off TFF filter modules were concentrated until a final volume of almost 150 ml using a smaller 500-kDa cut-off TFF filter module (C02-E500-10-N MicroKros) with a feed flow 75 ml/min and a permeate flow 2 ml/min samples were further concentrated and diafiltrated seven times with PBS reaching a final volume of approximately 5 ml the retentate obtained from the 650 nm cut-off TFF cartridge (100 ml) was diluted in modified f/2 medium to reach the initial batch volume (1.6 L) and used to start renewed cultures in bottles via a 25% v/v inoculum microalgae were again processed by TFF to isolate EVs necessary for the recycle of the microalgae cell culture the 650 nm TFF membrane filter was washed with 1 L of sterile water before starting the clarification process for the first TFF step the instrument and the bioreactors are connected in a closed system to maintain sterility The EVs protein content was quantified using the colorimetric BCA protein assay (Thermo Fisher Scientific The protein concentration was measured at 562 nm according to the manufacturer’s instructions using a GloMax® Discover Microplate Reader The Western blot analysis was executed using sodium dodecyl-sulfate (SDS) polyacrylamide gel electrophoresis (PAGE); 10 μg of cell lysate and 5 μg EV samples (in PBS) were incubated at 100°C for 5 min with 5× loading buffer (0.25 M Tris-Cl pH 6.8 0.25% bromophenol blue) and loaded on 10% SDS polyacrylamide gel for electrophoresis Polyvinylidene fluoride (PVDF) membranes are used to blot proteins The membranes were blocked with BSA-TBS-T solution [3% powdered with bovine serum albumin in TBST (50 mM Tris HCl pH 8.0 0.05% Tween 20)] for 1 h at room temperature is raised against a mammalian EV marker and is cross-reactive for microalgae incubated for 1 h at room temperature is raised against H+/ATPase a membrane protein specific for plants and protists membranes were incubated for 1 h with secondary antibodies according to the manufacturer’s instructions (horseradish peroxidase-conjugated secondary anti-mouse or anti-rabbit antibodies and then washed four times in TBST for a total of 20 min Immunoblots were revealed using SuperSignal™ Pierce™ ECL (Thermo Fisher Scientific) In the present work, we isolated EVs from the marine chlorophyte microalgae T. chuii (Figure 1A). This species was selected from a set of several microalgal strains as one of the best candidates for EVs production (Adamo et al., 2021; Picciotto et al., 2021) We established a permanent platform for microalgae cultivation at pilot scale Different cultivation methods are available for microalgae, in brief (Henley, 2019): • batch—a given volume of culture medium is inoculated with cell culture at low density and then processed during exponential growth to obtain a maximum yield; • fed batch—a supplement of culture medium and nutrients periodically feeds the cell culture without removing the biomass before harvesting; • semicontinuous—a fixed volume of cell culture is harvested at given time intervals and replaced with fresh culture medium; • continuous—the harvested culture is drained out of and the fresh medium is fluxed in the bioreactor continuously to maintain a constant biomass concentration The harvested cultures are then pooled and processed at the same time The harvesting time depends upon the life cycle of T. chuii as well as the culture conditions, such as the amount of the inoculated culture. Specifically, after 4 weeks the cell density increases to reach a maximum, as measured by periodic optical density measurements and cell counting. Along with the cultures fated to EV production, we maintained a refreshed stock culture, as described in the general flow chart of Figure 1C In our previous work, we have used both differential ultracentrifugation (dUC) and tangential flow filtration (TFF) to isolate EVs from microalgae, confirming the above described expectations for TFF performance (Adamo et al., 2021). Thus, we implemented the following procedure based on sequential TFF filtration steps (Figure 2) and feed for the three filters used in sequence: (i) 650 nm (iii) 20 nm (namely 500 kDa) The harvested cell culture is fluxed through a fiber with a cut-off of 650 nm to remove the biomass The clarified permeate from the previous step is fluxed through a fiber with a cut-off of 200 nm; this step allows to isolate EVs smaller than 200 nm in the permeate by removing larger objects including large EVs or cellular debris which escaped the first clarification The isolated permeate from the previous step is fluxed through a fiber with a cut-off of 500 kDa which corresponds to approximately 20 nm; this step allows to remove small particles maintaining small EVs in the retentate; at the same time the retentate volume is reduced down to the fiber volume (150 ml in the current setting) The ultrafiltered retentate from the previous step is fluxed through a fiber with the same cut-off (500 kDa) and a lower volume and filter surface; this step allows to further concentrate the sample by reducing the volume down to the volume of the filter module and the tubing (5 ml in the current setting) a culture with high protein content may result in quick membrane fouling affecting all TFF steps and preventing an efficient recovery In order to optimize the TFF protocol, the specific parameters controlling the process must be adjusted individually for each type of culture medium (Moleirinho et al., 2019) Two important parameters to maximize EV yield are the inlet and outlet flow rates: more specifically We evaluated three different conditions for each filtration step: (A) Fin = 750 ml min−1 Fout = 60 ml min−1; (B) Fin = 450 ml min−1 Fout = 6 ml min−1; (C) Fin = 450 ml min−1 Fout = 6 ml min−1 and filter module wash likely due to the prevention of any membrane fouling An additional washing step (condition C) may also improve particle recovery Nanoalgosomes size distribution in three TFF conditions as described in the text Characterization of nanoalgosomes obtained from the three different TFF conditions (A Dz: z-averaged hydrodynamic diameter; PDI: polydispersity index; Rex/biomass: excess Rayleigh ratio over dry biomass; NP (NTA): particle number After the optimization of upstream and downstream processing, we were able to produce EVs at a lab scale, with a maximum yield of 2 mg EVs for every 5 L of cell culture and approximately every 5 g of dry biomass. Also, our production platform showed high reproducibility and quality over different production cycles, as discussed in the present work and in our previous studies (Adamo et al., 2021; Picciotto et al., 2021) we explore the possibility to link upstream and downstream processes by implementing a cyclic bioprocess for nanoalgosomes isolation Since microalgae cells are concentrated during the first TFF filtration step the corresponding retentate could be used to seed a new culture via appropriate dilution with fresh medium (modified f/2 medium) and subjected to further sequential filtration after 4 weeks This requires that microalgal cells are not damaged during the first TFF step when the cell culture is depleted from the released vesicles Characterization of nanoalgosomes obtained from a fresh culture (R0) and after 1 over dry biomass; NP (NTA): Particle number Nanoalgosomes size distribution from a fresh culture (R0) and after 1 Immunoblot analysis of specific biomarkers (H+/ATPase and Alix) in Tetraselmis chuii cells lysate (Microalgae lysate; 10 µg) and nanoalgosomes isolated by TFF from Tetraselmis chuii fresh culture (R0) Ponceau red staining is shown as loading control (bottom panel) Three independent experiments (n = 3) were performed it is possible that their functional properties would not be altered AFM images (2 × 2 μm2) of nanoalgosomes (A) from a fresh culture and (B) from a culture after multiple recycles We reported different quantities related to the amount of vesicles in solution: protein mass concentration determined by BCA assay This quantity is a standard parameter in the EV field; its measure can be done by using a specific kit and a spectrophotometer or a colorimeter; thus it is quite cheap and easily accessible in every laboratory it is a widely used procedure and thus it is very useful to compare measurements from different studies and different samples Other colorimetric methods measuring protein mass concentration an accurate measurement of protein concentration typically requires a concentrated sample so it is often taken after a concentration step which introduces the possibility of sample loss and a biased measurement particle number concentration measured by NTA The number of particles is the ideal quantification for each sample and it is becoming another standard parameter with the increasing availability of NTA instruments or also Resistive Pulse Sensing techniques which allow to track and count each particle in a sample There are two main drawbacks: the first is the intrinsic limit of detection of NTA instruments which are less sensitive to objects with a size below 100 nm (or with a very large size) giving a constitutive bias to the measure of number concentration; the second is the intrinsic incomplete sampling of the particle population; indeed both a short experimental duration and a different setting of the acquisition parameters may lead to large differences in the particle count which only a highly trained operator can reliably and partly suppress one may note that the variability in the data does not allow to infer one quantity by simply measuring the other one we recommend to measure both quantities to complete any batch characterization Correlation among concentration parameters: (A) particle concentration measured by NTA (black circles) vs protein concentration measured by BCA assay (B) Protein concentration measured by BCA assay (blue circles) particle concentration measured by NTA (green circles) and z-averaged hydrodynamic diameter (red circles) vs Rex; The solid lines show a linear regression to data for BCA vs In any case, the correlation shown in Figure 7B works as an a posteriori calibration of the particle number with respect to the “hard number” of Rayleigh ratio which can be quickly measured to assess EV concentration and make a reliable and accurate batch to batch comparison a 90° excess Rayleigh ratio of 42 × 10–6 cm−1 corresponds to a number concentration of 1010 particles mL−1 The role of EVs in cell communication is attracting increasing interest from several clinical and biological fields. This emerging relevance is also supported by the application of EVs for clinical diagnosis and liquid biopsy (Ayers et al., 2019; Trino et al., 2021) their potential exploitation as efficient drug delivery systems boosted the interest in their biotechnological exploitation In order to fulfill the increasing demand for EVs it is required to adopt new strategies for their massive production at high purity level or Here, we addressed the production of nanoalgosomes, EVs derived from microalgae recently identified and characterized in our recent work (Adamo et al., 2021; Picciotto et al., 2021) Both upstream and downstream processing steps have been optimized to maximize EV yields we showed that it is possible to operate microalgal production cycles using TFF-derived culture inocula to facilitate a cyclical production of nanoalgosomes The optimization of EV production was achieved by implementing quality control checks which included the use of several biophysical and biochemical methods for EV characterization As highlighted in the present work and accounted in previous studies (Paganini et al., 2019; Adamo et al., 2021), nanoalgosomes have different competitive advantages with respect to EVs derived from other sources (Figure 8): 1) Sustainability They are obtained by a sustainable “green” biosource: they can be seen as more appealing for an exploitation as drug carriers than EVs from human or animal sources which have inherent safety and ethical issues The optimized TFF based bioprocess is suitable for a large scale production: for any large-scale exploitation a cell suspension has a definitive advantage with respect to other green sources which require more time-consuming and expensive treatments 3) Renewability—the potential recycling of TFF-concentrated microalgal cells to facilitate the scaled production Schematic representation of EV production as a sustainable (cultivation of microalgae) The raw data supporting the conclusion of this article will be made available by the authors and SR; writing + original draft preparation and MM; writing + review and editing and MM; All authors have read and agreed to the published version of the manuscript The authors acknowledge financial support from the VES4US and BOW projects funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No 801338 and 952183 The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Bergese for several useful discussions and support The Supplementary Material for this article can be found online at: 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Potential of Continuous Manufacturing for Liposomal Drug Products PubMed Abstract | CrossRef Full Text | Google Scholar Yáñez-Mó Biological Properties of Extracellular Vesicles and Their Physiological Functions CrossRef Full Text | Google Scholar Handling and Storage of Human Body Fluids for Analysis of Extracellular Vesicles CrossRef Full Text | Google Scholar The Function and Clinical Application of Extracellular Vesicles in Innate Immune Regulation PubMed Abstract | CrossRef Full Text | Google Scholar Bongiovanni A and Manno M (2022) Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess Received: 15 December 2021; Accepted: 01 February 2022;Published: 14 March 2022 Copyright © 2022 Paterna, Rao, Adamo, Raccosta, Picciotto, Romancino, Noto, Touzet, Bongiovanni and Manno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Nicolas Touzet, VG91emV0Lk5pY29sYXNAaXRzbGlnby5pZQ==; Antonella Bongiovanni, YW50b25lbGxhLmJvbmdpb3Zhbm5pQGNuci5pdA==; Mauro Manno, bWF1cm8ubWFubm9AY25yLml0 †These authors have contributed equally to this work Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Nov 5 (EFE).- Spanish authorities announced Tuesday that there are 89 active missing persons cases one week after a devastating storm and subsequent flooding hit the province of Valencia the first official count of missing persons released by the Spanish authorities only applies to the eastern province of Valencia where 211 of the 217 confirmed deaths occurred 62 bodies at the Forensic Medicine Institute of Valencia have not yet been identified Active cases correspond exclusively to missing persons reports in which relatives have provided data and biological samples for identifying their loved ones according to the High Court of Justice of the Valencian Community The Data Integration Center of the Guardia Civil and the National Police pointed out that the reports of missing persons with an active file do not correspond to the total number of missing persons as there may be cases of disappearance that have not yet been reported The kind of data that can be provided by the relatives of missing persons in the forensic offices to facilitate identification range from photographs In the case of identification through genetic profiling the most reliable biological samples are those of direct relatives in the ascending or descending lines as well as the provision of personal belongings of the missing person Paterna covered the 3.1-mile course in 19 minutes trailing just Bedford junior Mikita Barry who won in a time of 19:18.79 More: Here are 18 Seacoast high school girls cross country runners to watch in 2024 Pinkerton beat the 19-team field with 92 points Concord (178) and Nashua North (178) placed third through fifth More: Here are 18 Seacoast high school boys cross country players to watch in 2024 Dover (210) placed 10th, Winnacunnet (218) was 11th, Portsmouth (249) was 12th and Spaulding was one of three teams that didn’t have a team score.  Dover senior Anique Poulin was fourth in 20:18.74.  Other top-10 finishes were turned in by Portsmouth senior Sophia Cosgrove (sixth, 20:45.14), Winnacunnet senior Carson Mariotti (seventh, 20:48.10), and Exeter sophomore Brianna Paterna (ninth, 21:05.47).  Oyster River second in Division II girls Senior Haley Kavanagh placed first overall in a time of 19:09.34, leading Oyster River to a second-place finish in the Division II state meet.  Oyster River had a team score of 50, trailing just Hanover (30). Plymouth (111), Souhegan (137) and Coe-Brown (162) placed third through fifth, respectively in the 17-team field.  Oyster River freshman Olivia Kavanagh and sophomore Madelyn Cook placed third (20:04.54) and sixth (20:29.09), respectively.  Newmarket, PCA girls in Division III top-10 Newmarket senior Ellis McKenna placed fifth overall in 21:16.62, leading the Mules to a fourth-place finish in the Division III race.  Hopkinton won with a team score of 30, while Gilford (71) and Newfound (109) rounded out the top three.  Portsmouth Christian Academy was eighth (240), and St. Thomas Aquinas was 15th (300).  PCA’s Elizabeth Stewart, a seventh-grader, placed 21st (23:15.86) and St. Thomas Aquinas junior Ava Malloy was 38th (24:37.63).  Senior Spencer Mann placed 16th in a time of 17:25.79 as Exeter had a team score of 196 and placed seventh in the Division I state meet.  Bishop Guertin won with a score of 65, while Pinkerton (73) and Nashua South (84) was second and third, respectively.  Portsmouth (295) was 12th, Winnacunnet (485) was 16th, Spaulding (551) was 18th and Dover (557) was 19th.  Portsmouth senior Nolan Peters was 11th in a time of 17:01.   Oyster River had three runners in the top 15 as the Bobcats had a team score of 108 and placed third in the Division II state meet.  Hanover (39) and Coe-Brown (53) placed first and second, respectively.  Oyster River senior Mitchell Keesee (17:38.04) and sophomore Oliver Lehman (17:38.73) placed 11th and 12th, respectively, and sophomore Levi Clapp (17:58.19) was 15th.  Three Seacoast teams in Division III boys top-five Newmarket and Portsmouth Christian tied for third with a team score of 139, while St. Thomas Aquinas (145) was fifth.  PCA junior Christian Barnes was fourth overall in 17:07.22. Other top-25 placements came from Newmarket senior Jaron LaBranche (13th, 18:47.14), STA junior Oliver Schartner (14th, 18:50), STA senior Mason Ruger (17th, 18:54.03) and PCA senior Owen McKenney (24th, 19:21.93).  Madrid-raised German-American breaking news in Spain and Portugal. Previously covered markets in Germany, Austria and Switzerland, with a special focus on chemical companies and regular contributions to Reuters' German-language service. Worked at Spanish news agency EFE (Madrid/Bangkok) and the European Pressphoto Agency (Frankfurt). BOSTON – The Exeter High School girls track team set a school record at Saturday’s New England high school indoor track championships at the Reggie Lewis Center and Eli Cross placed fourth in the 4x800-meter relay in a time of 9 minutes Exeter’s Lexi Paterna placed fifth in the two-mile in 11:02.43 DERRY - Spaulding's Mackenzie Lacoss (145 pounds) and Sadie Nadeau (152) both won their respective weight classes at the Meet of Champions at Pinkerton Academy it was her second straight Meet of Champions title at 152 pounds Spaulding scored 76.5 points and placed eighth overall in the 38-team field Spaulding's Jayden Deal (144) placed second in his weight class and Sawyer Goodwin (175) and Wesley Chesser (285) both placed third Chesser and Deal all qualified for the upcoming New England Championship DOVER - Gabe Carlisle's three goals and one assist helped St Thomas Aquinas (14-4) in its Division II win at Dover Ice Arena Jack Kelly and AJ Kozlowski all had a goal for the Saints while Jackson Estes had a goal and four assists Exeter High School girls track coach Nate Leveille predicted how well his team could do in Saturday’s Division I state championship meet at Plymouth State University “We’ll go as far as our middle-distance runners go,” Leveille said The middle-distance events Leveille speaks of is the 1,000- Exeter has five runners seeded in the top 10 led by a trio of sophomores Eli Cross (ranked second at 3 minutes freshman Claire Wilhelm is ranked eighth (3:13.34) and Brianna Paterna is seeded seventh (5:00.85) Alexis Paterna is seeded first in a time of 10:24.30 “We’re asking a lot from (Alexis Paterna) on Saturday,” Leveille said “She’s coming off a huge cross country season for us.”  Leveille hopes Cross can stay true to her seed (second) in the 1,000 and help the top-seeded Blue Hawks win the 4x800-meter relay “We’re looking for (Cross) to be a part of a couple of big relays and secure that runner-up finish in the 1,000,” Leveille said we can win the meet; there’s no doubt in my mind.”  Exeter's top-seeded 4x800 relay consists of Cross The third-seeded 4x400 relay is comprised of Martelle McBride Caron and Maddie Poteet; and the Blue Hawks’ 4x200 relay is seeded sixth Leveille said the shot put is “super important” for Exeter’s success Saturday Exeter has three of the top-five seeds in the 600 in Caron (second) McBride is seeded sixth in the 300 and long jump and seventh in the 55; and Sydney MacVicar is seeded seventh in the 55 hurdles Portsmouth coach Stan Lyford said there will be a big gap between the first five teams – Exeter Pinkerton – and the rest of the 21-team field no one will be able to touch them,” Lyford said “There’s a big gap between fifth (place) and sixth.”  Lyford expects his Clippers to finish in the top 10 Lyford says sophomore Molly Flynn “could do something” in the 55-meter hurdles where she is seeded third and fourth in the high jump; and junior Ginger Vinciguerra is seeded ninth in the 600 “I think the bulk of our points will be in the three relays but hopefully we can do better than we think,” Lyford said Portsmouth’s three relays will be the 4x400 (seeded fifth) Georgia Parrott and Houghton; and the 4x200 consists of Elliott Blenkinsop Other top-10 seeds for Portsmouth include Carolyn Milks in the 55 hurdles (eighth) Shorthanded Winnacunnet girls shooting for individual success Winnacunnet head coach Cassie Kruse said the Warriors will be looking for season-best results “We’re short on numbers this year,” Kruse said “A great day for the girls would be placing as high as they can in their events and come away with some personal bests.”  Senior Lola Grote is seeded ninth in the 55-meter hurdles “(Grote’s) goal is to make the final race," Kruse said "Placing in the top eight in the state would be huge."  The only other individual top-10 seed from Winnacunnet is senior Maitri Clifford who is seeded 10th in the 300 the 4x200 (seventh) and 4x400 (eighth) are seeded in the top 10 Dover's Kirk seeded in girls top-10 in two eventsDover senior Zoe Kirk is seeded fourth in the high jump and sixth in the 55 hurdles "Zoe has worked so hard over the past four years to develop into a top track and field athlete in New Hampshire," Dover head coach Nicholas Piatti said "Hurdles has been her main focus this season with the ultimate goal of finishing on the podium." Kirk also will run a leg in Dover's 4x200 relay team which is seeded 11th "With a chance to score in three events she could be our top performer at the meet," Piatti said Dover senior Jordyn Bolobanic is eighth in the 55 hurdles and freshman Kathleen Lynch is eighth in the 300 Portsmouth boys eyeing top-four finish Portsmouth head coach Mike Lyford isn’t ruling out a run at a Division I state title Saturday at Plymouth State University but he calls Pinkerton an “overwhelming favorite.”  but I think on a good day we can surprise some people,” Lyford said “We have a dedicated core of seniors that really drive what we do We have a thinner roster in terms of depth than previous years Portsmouth senior Theo Beattie and junior Will Hart are seeded first (1:24.38) and third (1:25.05) Senior Josh Kelly is seeded second in the long jump (21 feet 00.75 inches) and third in the 55 hurdles (7.93) Senior Nolan Peters is third in the 3,000 (9:14.24) and seventh in the 1,500 (4:14.94) And Portsmouth is seeded in the top-five in all three relays The Clippers are second in the 4x400 (3:35.50) and fifth in both the 4x200 (1:17.23) and 4x800 (8:48.49) Briggs Catino and Will Hart; the 4x200 is comprised of Catino Beattie and Ethan Lander; and the 4x800 consists of Beattie Other top-10 seeds for Portsmouth include Catino in the 300 (third Winnacunnet head coach Cassie Kruse says the size of her team will prevent them from making a run at a second consecutive top-three showing at the state meet but she is confident a couple of state titles are within reach I’d be pretty happy with that,” Kruse said but we’re looking for some state titles.”  Senior Ryan Zumbach is seeded first in the 1,000 (2:35.23) and senior Owen Janetos is seeded first in the 300 (36.16) Both also run a leg of the top-seeded 4x400-meter relay team The foursome set a Winnacunnet school record earlier this season in a time of 3:32.9 seconds “That’s going to be an exciting race,” Kruse said “We’re hoping to come away with a state title but it will be tough because all of runners have other events that day They’ll need to power through and come back and run a hard relay but if we run our “A” game we can definitely come away with the title.”  The same quartet is seeded seventh in the 4x200 relay (1:17.41) Other top-10 seeds for Winnacunnet include Jamison in the 55 hurdles (seventh Exeter boys focused on individuals Leveille was candid with the outlook of his boys team but we have solid individuals going up there looking to place,” Leville said Senior Kellen Bateman is the highest seed for the Blue Hawks coming in at third in the shot put (47-09.50) Senior Spencer Mann is seeded seventh in the 3,000 (9:17) and eighth in the 1,500 (4:17.2) Other top-10 seeds for Exeter include senior Phineas Reardon in the 300 (fourth senior Thoren Kersten-Guiler in the long jump (eighth 19-11.75) and senior Brodie Proulx in the 300 (10th Dover junior Melo Berdecia is seeded fifth in the 1,000 (2:40.3) and Spaulding senior Eli Benjamin is second in the high jump (6-03) The Seacoast high school Athletes of the Week winners for March 10-15 are Exeter High School girls indoor track athletes Lexi Paterna and Oyster River High School boys basketball player Max Scopel presented by York County Community College The weekly polls runs each Monday through midnight Thursday, and can be found at seacoastonline.com/sports and fosters.com/sports The honors are presented by York County Community College More on boys winner Max Scopel of Oyster River High SchoolScopel won the online poll by receiving 292 votes (47%) Exeter basketball player Nik Greco placed second with 167 votes Thomas Aquinas hockey player Aiden Tibbetts was third with 152 votes Scopel scored 14 points in Oyster River's Division II semifinal loss to Sanborn last Monday "Max has been one of the hardest workers all season," Oyster River head coach Zach Lewis said "It's really great to see his work being recognized by people outside of the team." received 250 votes and won the athlete of the week honors with 52% of the vote The Exeter quartet placed third at the Nike Indoor Nationals in a time of 9 minutes 15.17 seconds earning All-American status at The Armory in New York City The group also broke its own school record of 9:23.84 Oyster River hockey player Mallory DeSantis placed second with 128 votes and Oyster River track athlete Haley Kavanagh placed third with 100 votes "It's a great honor to win athlete of the week as a group as the four of them wouldn't want it any other way," Exeter head coach Nate Leveillie said NEW YORK - The Exeter High School girls track relay team saved its best 800 meters for its final race of the season Exeter's sophomore quartet of Lexi Paterna Izzy Bremer and Eli Cross shattered its own school record in the 4x800-meter relay at the Nike Indoor Nationals at The Armory in New York City The Exeter foursome placed third overall in a time of 9 minutes "Going into the race we were all pretty nervous because we knew we were racing against some of the fastest kids in the country," they said "But we also knew the race was going to be very competitive and we wanted to do our best in order to see what we were capable of achieving We are thrilled with the outcome and are so happy we got to share this experience Overall we feel extremely grateful to be given this opportunity and even more so to share it with each other." Bucks County (Pennsylvania) High School won the 20-team field in a time of 9:13.53 while North Stars (New York) placed second in 9:14.02 The top six teams earned All-American status "I am speechless," Exeter head coach Nate Leveille said "They could not have run a better race as a team The Exeter High School indoor track school record in the girls 4x800-meter relay has been broken numerous times in the past 12 months The record was most recently broken last weekend at the New Balance Rising Stars Classic Track meet in a winning time of 9 minutes Izzy Bremer and Eli Cross hope to break it again Saturday on the biggest stage — at the Nike Indoor Nationals at The Armory in New York City but you have to take advantage of everything when it presents itself,” Exeter coach Nate Leveille said The team will compete in the 20-team championship division relay I think we can make a run at All-American (top six) status,” Leveille said “I don’t think that’s an unreasonable expectation.”  All four competed at last year’s Nike Indoor Nationals as Bremer and Cross joined Clara Knab and Danica Caron in the Emerging Elite 4x400-meter relay “If you’ve never been to a national meet before they won’t be a deer in the headlights this year Exeter will also field a 4x400-meter relay team in the Emerging Elite division with Caron That race is scheduled for Sunday at 1:29 p.m The New Balance Indoor Nationals are scheduled for Saturday at the Reggie Lewis Track and Athletic Center in Boston and several Seacoast runners are scheduled to compete Winnacunnet senior Ryan Zumbach will compete in the 800 and junior Ryan Janetos will run in the 200 “I am excited for them both,” Winnacunnet coach Cassie Kruse said and another experience for them they will never forget and another opportunity to compete at a really high level.”  At the NHIAA Division I state meet last month at Plymouth State Oyster River senior Mackenzie Cook is scheduled to compete in three events – the mile the 5,000 and a leg on the Bobcats’ distance medley relay Senior Haley Kavanagh is scheduled to compete in the mile and the distance medley relay Maddie Cook and Avery Bumgardt will run the other two legs on Oyster River’s distance medley relay Also, Kavanagh won the 1,500 (4:33.31), and was part of both winning 4x400-meter (4:21.48) and 4x800-meter (10:09.46) relays. Her time in the 1,500 set not only a Division II record, but also a state record In the boys competition, Oyster River senior Talon Ouellette is scheduled to compete in the 200 and a leg in the sprint medley relay. Other relay members include Micah Gedney, Owen Mazza and Mitchell Keese.  Volume 17 - 2023 | https://doi.org/10.3389/fnsys.2023.1197350 This article is part of the Research TopicDistributed networks: new outlooks on cerebellar function - Volume IIView all 19 articles Post-traumatic stress disorder (PTSD) and anxiety disorders are among the most prevalent psychiatric conditions worldwide sharing many clinical manifestations and neural mechanisms as suggested by neuroimaging research While the so-called fear circuitry and traditional limbic structures of the brain have been extensively studied in sufferers of these disorders the cerebellum has been relatively underexplored The aim of this paper was to present a mini-review of functional (task-activity or resting-state connectivity) and structural (gray matter volume) results on the cerebellum as reported in magnetic resonance imaging studies of patients with PTSD or anxiety disorders (49 selected studies in 1,494 patients) regarding the direction of effects and anatomical localization cerebellar structures like the vermis seem to be highly involved the neurofunctional and structural alterations reported for the cerebellum in excessive anxiety and trauma are complex although mixed results are found across disorders While it can be hypothesized that individual differences in cerebellar activation underlie reactivity to stressors (Moreno-Rius, 2019) and the risk for developing anxiety and stress-related disorders (Caulfield and Servatius, 2013) a clear understanding of how the cerebellum contributes to excessive anxiety and stress is lacking The aim of this mini-review was to describe the main findings of human neuroimaging studies using structural (sMRI) or functional (fMRI) magnetic resonance imaging in adult patients suffering from PTSD or anxiety (SAD with adult participants (>18 years of age) that had received a clinical diagnosis in either patient-control or pre-post-treatment comparisons were included Exclusion criteria were research articles that used: (I) another neuroimaging modality than sMRI or fMRI; (II) pediatric or adolescent populations or healthy individuals only; (III) neuropsychiatric disorders different than the targeted PTSD/anxiety disorders; and (IV) meta-analyses Figure 1. PRISMA flow diagram of the mini-review. Adapted from Page et al. (2021) Task-based fMRI studies mainly used disorder-relevant challenges to obtain the neural activation maps during task (disorder-relevant stimuli) compared to control conditions (neutral stimuli) Most rs-fMRI studies measured functional connectivity (FC) between the cerebellum and other brain regions (intrinsic connectivity distribution) or at intra-cerebellar network level (intra-network FC) Structural MRI studies mostly used voxel-based-morphometry (VBM) to identify variations in gray matter volume (GMV) The vast majority of studies were cross-sectional comparing patients vs controls while some were treatment studies evaluating pharmacotherapy and/or psychological interventions with pre-post within-group evaluation or treatment vs Two studies also used a machine learning approach to classify groups this mini-review evaluated functional (task activity resting state connectivity) and structural (gray matter) findings on the cerebellum reported in MRI studies of patients with PTSD or anxiety disorders this mini-review described and briefly evaluated functional and structural neuroimaging studies reporting on the cerebellum in adult participants with anxiety disorders or PTSD acting as a limbic node in the cerebellum for emotions could have a more prominent role in these disorders it is also evident that the MRI studies evaluated herein report anatomically distributed findings involving motor as well as non-motor regions of the cerebellum The functionality of each cerebellar subregion is complex and the consistency and direction of cerebellar involvement across the disorders need further evaluation longitudinal and cross-sectional studies and large-scale networks in combination with the use of ultra-high field MR scans offering improved anatomical precision could provide a better understanding of the role of the cerebellum in post-traumatic stress and anxiety disorders Both authors contributed to the design and conceptualization This project has received funding 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Cerebellar neural circuits involving executive control network predict response to group cognitive behavior therapy in social anxiety disorder Multimodal MRI-based classification of trauma survivors with and without post-traumatic stress disorder Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder Citation: Gil-Paterna P and Furmark T (2023) Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review Copyright © 2023 Gil-Paterna and Furmark. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Patricia Gil-Paterna, cGF0cmljaWEuZ2lsLXBhdGVybmFAcHN5ay51dS5zZQ== Over 500 children from FBCD Catarroja and Atlético Sedaví CF begin training at the Club's facilities in Paterna Valencia CF opens the Ciutat Esportiva de Paterna to the clubs of the #EscolesVCF programme affected by the flash floods whose facilities have been seriously damaged so that children and youngsters can resume their sporting activities Around 500 players from FBCD Catarroja and Atlético Sedaví CF have started training this week at the Valencia CF Ciutat Esportiva facilities that the Club has offered to the 4 most affected VCF Schools so that they can make use of them over the coming months The entrance was already an emotional experience for these young footballers who have been affected by the flash floods For some of them it was their first time at the Ciutat Esportiva del Valencia CF they received the warmth of the VCF Academy players and coaches who made a corridor as a sign of support and solidarity with all of them Just by seeing the children's faces and their smiles you realise how they have experienced it and how much it helps them Seeing the children on a football pitch is what we have been wanting for a long time Valencia CF corporate director Javier Solis VCF Academy director Luis Martinez and club ambassador Miguel Tendillo were also waiting to show their support They were joined by first team player Thierry Correia who surprised the young players of FBCD Catarroja and took part in the group photo in which representatives of FBCD Catarroja together with the Puma Clubs Coordinator in Spain received the sports equipment and balls that Puma has donated to collaborate in their return to football both at the Ciutat Esportiva de Paterna and at other facilities in the case of UD Aldaia and Racing Algemesí ‘It has been unforgettable,’ explains Arnau ‘We didn't expect that they would make the guard of honour and that Thierry Correia would come’ ‘Our pitch is waterlogged and we have nothing or almost nothing,’ explains Daniel who is grateful to be able to train at the Ciutat Esportiva del Valencia CF They will be able to do so over the next few months when the Ciutat Esportiva del Valencia CF will host the players of FBCD Catarroja and Atlético Sedaví CF so that they can train and have fun with football in a return to training that will also count on the collaboration of Coca-Cola It is just a first step to recovering football for the youngest children in these towns that have been so badly affected by the flash floods and so that at least for a few hours the ball can make them smile again The pitch has been restored thanks to donations from LALIGA EA SPORTS and contributions to the ‘FILA CERO SOLIDARIA’ The VCF Academy received the Rigth2Dream International Academy protagonist during the last African Cup of Nations Soccer has a universal language and an illusion that unites all those who start kicking a ball: to become professional players That shared dream was staged this Tuesday by a group of U19 players from the VCF Academy who received the Rigth2Dream Academy at the Ciutat Esportiva del Valencia CF the fourth best in Europe in the training of players to compete in the elite an international academy originally from Ghana but which also has branches in Denmark and Egypt The young players from both academies faced each other in a friendly match in which they wanted to show their bond with a joint photograph The VCF Academy has produced great players who have gone on to play professional soccer at Valencia CF and who have also competed for top clubs in England Rigth2dream has been recently highlighted because in this academy was two years Simon Adriga player who recently has been proclaimed champion of the African Cup with Costa del Marril and has been designated MOTM of the final and best U23 player of the tournament beloved husband of 51 years to Patricia Paterna he was the son of the late Thomas and Domenica “Minnie” Paterna Lucille (Michael) Tuminello and Felicia (Louie) Vitale; brother-in-law and Lauren and Jenna Rossi; and many friends He was predeceased by his sister and her husband A Walk Through Wake will take place from 4:00 p.m Masks and social distancing will be required Milford (MEET DIRECTLY AT CEMETERY) with a reception to follow Jude Children’s Research Hospital at www.stjude.org.  St. Jude Children's Research Hospital501 St. Jude Place, Memphis TN 38105Tel: 1-800-805-5856Web: http://www.stjude.org/ -- A Freeport man was arrested and charged with DUI manslaughter for a deadly motorcycle crash in Walton County from July 50-year-old Michael Paterna is charged with DUI manslaughter and vehicular homicide for a crash on County Road 3280 and Magnolia Road from July 2. Paterna was operating a 2005 Yamaha motorcycle and traveling east on County Road 3280 with a female passenger throwing both him and the passenger into a fence The passenger did not survive and was pronounced dead on scene Paterna suffered serious injuries and was taken to Fort Walton Beach Medical A search warrant was obtained for Paterna's blood samples which came back with results that tested positive for alcohol Florida Highway Patrol Corporal James Durham was able to reconstruct the crash and discovered Paterna was traveling between 66 and 70 miles per hour in a 35 mile per hour zone Paterna was arrested and booked into Walton County Jail He was released Thursday afternoon on $50,000 bond We have the address for the funeral home & the family on file If you're not happy with your card we'll send a replacement or refund your money Information on COVID-19 Funeral Assistance through FEMA \u003ca href=\"/resources/funeral-assistance\"\u003eRead More\u003c/a\u003e Paterna created this Life Tributes page to make it easy to share your memories © 2025 John Vincent Scalia Home for Funerals Inc. Made with love by funeralOne On Saturday July 28, Salvatore (“Tori”) and Susanne Paterna celebrated their 50th wedding anniversary at Boston’s Seaport Hotel. Tori, now retired, formerly owned and operated John Solomon’s Inc. on Somerville Avenue in Somerville. Until retirement, Tori and Susanne lived on Bailey Road, in Somerville’s Ten Hills neighborhood. They recently moved to New Hampshire and keep a winter home in Florida. Happy 50th wedding anniversary Tori and Sue! AVAMET (Associació Valenciana de Meteorologia) said several locations in the city of Valencia recorded more than 200 mm of rain in 24 hours to 03 May 2022 The weather station at Camins al Grau in the city recorded 260.9 mm Further heavy rainfall fell early on 04 May Emergency Services 112 Valencia reported Algemesí municipality saw 70.4 m of rain in 4 hours early on 04 May firefighters rescued several occupants of vehicles trapped in flood waters in Paterna Firefighters carried out over 50 interventions and local police 94 interventions At least four road tunnels in the city were flooded Some schools have been closed and rail services interrupted or suspended Other areas of the country have also seen severe weather in recent days hail and heavy rain caused flooding and damages in parts of the Murcia Region Murcia emergency services said around 30 mm of rain fell in 1 hour on 02 May 2022 Emergency services (112 Murcia) responded to 48 weather-related incidents An intense hailstorm caused damages in Bullas Hail and heavy rain also affected areas further north including 16 interventions for flood water clearance — Bombers Consorci VLC (@BombersValencia) May 4, 2022 — AEMET_C. Valenciana (@AEMET_CValencia) May 3, 2022 Se activa los planes municipales de emergencia de #Caravaca y #Cehegín https://t.co/alHo6tGmoO pic.twitter.com/7lmwZU2e9f — 112 Región de Murcia (@112rmurcia) May 2, 2022 Richard Davies is the founder of floodlist.com and reports on flooding news Cookies | Privacy | Contacts © Copyright 2025 FloodList Families finally recover the remains of 21 of the 3,400 Republicans executed after the Spanish civil war The families who gathered in a Spanish cemetery beneath Saturday’s burning sun had waited 82 years They weren’t going to let the 30C heat stop them doing what they had come to do Pit 111 of Paterna cemetery in the Valencia region finally gave up the remains of 21 of the 3,400 Republicans who were summarily executed by Franco’s forces after the end of the Spanish civil war and whose bodies were tossed into an enormous and infamous mass grave were returned to the families of the murdered in a solemn ceremony which has worked to reunite the bodies of the dead with their descendants said a last goodbye to his wife and children In a pit within this small square were found 150 bodies Photograph: Pablo Garcia/The Guardian“If they kill me it will be because I didn’t think like them and because I served my legally elected government,” it read I want you to know that if there really is an afterlife Goodbye forever from your husband and father Sanz and his fellow victims were shot between March and May 1940 almost a year after Franco’s victory in the Spanish civil war All of the 150 bodies painstakingly recovered from the seven-metre depths of Pit 111 showed the same treatment They had lain in the earth of eastern Spain for almost nine decades as the country grappled with the legacy of the coup that brought Franco to power and with political and social disagreements over how best to make peace with the past Much of the information on where the exhumations were based came from Leoncio Badía, a grave-digger who secretly passed details to the families of those killed. His meticulous record-keeping was vital to Arqueoantro one of the associations that helps families find their civil war dead While work to exhume the grave began in May 2020 efforts were badly affected by the pandemic brought the day for which so many families had prayed Lina Torres Baena (left) and her daughter Yolanda wait to recover Amadeo’s belongings Photograph: Pablo Garcia/The GuardianLina Torres Baena wore black and clutched a carnation tied with a ribbon in the colours of the Second Spanish Republic as she received his remains the pencil he used to write his letters home and the soles of the shoes he was wearing on 6 April 1940 “He was 28 when he was shot,” said Lina’s daughter Lina’s mother never spoke to her daughter about her father for fear of reprisals “My mum is one of those who never knew anything about her father,” said Yolanda “She’s one of the daughters of silence but she’s happy to have her father back now and to be able to bury him properly.” Nearby stood the family of Regino García Culebras a Republican soldier whose murder left behind his wife and six children The remains of Regino García Culebras are returned to his family Photograph: Pablo Garcia/The Guardian“They arrested my father in 1939 and shot him on 27 March 1940,” said his daughter Rosa “They gave him the most summary of trials and then they shot him we’d already been through a year of misery We didn’t have to look for his remains for years because my mother always knew which grave he was in.” For those who gathered in Paterna on Saturday, the event was as overdue as it was welcome. Eighty-three years after it ended, the civil war and the subsequent dictatorship continue to cause personal pain and political skirmishes Spain’s socialist-led government is hoping to build on landmark legislation from 2007 with a “democratic memory” bill intended to “settle Spanish democracy’s debt to its past” The plans have been criticised by the opposition conservative People’s party which says the proposed legislation will serve only to “dig up grudges” and churn up the earth that was carefully tamped down with the post-Franco amnesty law and the so-called pact of forgetting the recovery of remains is a basic human and democratic right The grandchildren of José María Balaguer Gómez recover his remains to bury him with his wife and fulfil the dream of their parents who died without knowing where the remains were Photograph: Pablo Garcia/The GuardianClutching the box that held the remains of a man they never knew the grandchildren of José María Balaguer Gómez who was 56 years old when he was shot on 27 March 1940 said they had come to do what their parents and grandmother were never able to “We’ve come,” said his granddaughter María A fantastic week at the Ciutat Esportiva de Paterna Over thirty players from Albania and Montenegro countries with a growing interest in football have enjoyed a unique experience in VCF's Training Stage The players who traveled to Valencia had participated in the VCF Soccer Camp last summer in Albania and Montenegro and with this Training Stage they have had the opportunity throughout a training session with the coaching staff of the VCF Academy The experience allowed them to get to know first-hand based on the methodology of one of the best academies in Europe in training players for the elite according to the latest reports from the CIES Football Observatory they were able to play some games with teams from the VCF Academy and the VCF Escoles as well as enjoying with their families and coaches a complete experience on the Mestalla Tour a Valencia CF home game in Mestalla and a VCF Femenino match in the Antonio Puchades The presence of these players at the Ciutat Esportiva de Paterna is one more step in their approach to Valencia CF after having participated this summer in the VCF Soccer Camp held in Tivat (Montenegro) and in Tirana (Albania) BENSONHURST — Bensonhurst-born home cook photographer and graphic designer Daniel Paterna is dishing up more than mouthwatering recipes in his new cookbook “Feast of the Seven Fishes: A Brooklyn Italian’s Recipes Celebrating Food & Family.” Through lovingly rendered photographs readers also get a taste of the neighborhood’s little Italian bakeries alongside a highly personal family memoir.  The Bensonhurst backdrop gives rich context to recipes for dishes like arancini a traditional Italian cheesecake made with ricotta instead of cream cheese “I think anyone that has it is kind of over the moon,” said Paterna Paterna began to think about the food and the culture of Bensonhurst as something to be preserved after a few years away in Boston in the ‘90s he wanted to document his family’s Italian traditions like the Feast of the Seven Fishes a meal with seven different seafood dishes customarily served on Christmas Eve.  I started to photograph my mom cooking,” Paterna said this is a very unique thing that we do every year.” Paterna also started visiting Bensonhurst’s “negozi,” or little Italian shops many of which have been run by the same families for generations to photograph and interview the proprietors.  those efforts are compiled in “Feast of the Seven Fishes,” out from PowerHouse Books Nov family snapshots and stunning original photographs by Paterna almost entirely shot on Kodak 400 ASA.  “I was committed to shoot everything on film,” Paterna said “I felt that the work I was presenting and the concepts the emotions I was evoking were all taking place in the film era.” Paterna’s grandfather left Naples and settled in Red Hook around 1915 right at the tail end of a massive wave of immigration that brought roughly two million Italian immigrants to the city Like many of the grandchildren of those immigrants known for its Italian shops and restaurants and for its annual street fair honoring Santa Rosalia When Paterna was growing up, the neighborhood was also known for its mob presence, and for outbursts of racial violence and bigotry One of the goals for the book that Paterna had from the outset was to portray Bensonhurst’s “B-Side,” the side of the middle class Italian-American neighborhood that defies stereotypes.  Paterna says he encountered those stereotypes often People would ask if he knew anybody in the Mafia Coworkers found his Brooklyn accent intimidating and one even suggested speech therapy.  “I always felt like we grew up in a very dignified house,” said Paterna “My mother abhorred ‘The Sopranos.’ There’s no identification And I think that’s because it was all too real for us… you step out in the street you could run numbers or be part of an organized crime outfit very easily sang in the choir at church and was a seamstress and a bank teller She spoke Italian and would help new immigrants to set up bank accounts establish themselves in the neighborhood.  Her reputation in the community helped Paterna as he was visiting shops in Bensonhurst to photograph and interview the sometimes-reluctant owners It also came in handy after he finished the book he mailed an advance copy to Michael Lomonaco the former Food Network host and chef at Windows on the World.  he had worked at a bank with Paterna’s mother.  ‘Had I not seen the word ‘Paterna’ on that FedEx I would have never opened it,’” Paterna said “I really feel like my mom had a direct hand.” Lomonaco read the book and wrote a glowing preface “This deeply personal book is meant to move you to help you understand the story of one family and to see that so many other families lived much like this.” Paterna says the book is a way to preserve not just his own family’s traditions but the traditions of a changing neighborhood.  “Me photographing these stores and the area was sort of like a way to hold onto what’s left,” Paterna said “I think that’s what people are reacting to when they see the book.” Insfraestructuras y Territorio published the change of use of the land located next to Heron City Paterna where this American giant is expected to be installed After 14 years with an empty site and without the promised arrival of Ikea for whom this land plan was originally conceived the rezoning will allow for a smaller commercial and office area The buildable area has been reduced by more than 42% from 179,468 square meters to 103,932 square meters and now contemplates an extension of the streetcar line T4 and eliminates the need to undertake two crossings over the CV-35 (one lower and one upper) Now, according to levante-EMV as of July 2024 the city council has approved the sector’s detailed planning and will soon open the documentation to the public with a view to opening the hypermarket in 2025 Costco is expected to have a surface area of approximately 15,000m2 with an investment of 100 million euros and 250 jobs multinational already has a presence in Seville After its fifth opening in Spain this summer In this center you will be able to buy all kinds of products in large format: from food to household appliances Costco has more than 800 stores in 13 countries around the world Its main feature is that in order to make purchases it is necessary to become a member and pay an annual fee of 36.3 euros (for private customers) or 30.25 euros (for companies and self-employed workers) The underground rapid transit lines have been under construction for almost two decades due to various project delays The cross pinnacle on the Tower of Jesus Christ will be ready to receive visitors in 2026 on the centennial of Gaudi’s death Now you can get your wine in Talence by paying directly in Bitcoin That’s because the state has to spend money on updating the railway infrastructure rather than subsidizing the cost of the popular pass Steffen Romstöck said that he would respect the residents’ choice and would take over the helm of the municipality which will come into force from 1 January 2025 Rethinking renewable energy sources for the urban landscape But operating them is still illegal under the country’s legislation can inform and inspire communities and entrepreneurs that still feel trepidation at the prospect of energy transition it has a unique modular design that allows it to be shortened and lengthened like a train that’s the promise made by the mayor of Paris the district has long been known as the hangout spot for the artsy crowds Hostal de Pinós is located in the geographical centre of the autonomous region the ranking considers several distinct but essential factors these quiet areas will now be available on all main routes in the country The academic institution shows a deeper understanding of the well-being of its students These are stark monuments to housing shortage crises that occurred more than 200 years ago the Spanish municipality of Paterna reported that work has begun on renovating the Cultural Space of the Cuevas del Batà Cuevas in Spanish means ‘caves’ and in this case refers to historic urban dwellings that have been dug into the ground somewhere between the end of the 18th and the beginning of the 19th century Many of these curious urban caves are still inhabited today and thus represent an important architectural and socio-cultural heritage for the town these urban caves owe their existence to pitfalls in the socio-cultural developments in much more modern times – about 200 years ago Three conditions led to people considering the option of underground homes: growth in the local population an increase in the seignorial rents and the deteriorating conditions of labourers These factors meant that inhabitants could not afford to own their own homes and turned to excavating the calcareous and soft rock found in Paterna These dwellings have their own vents and chimneys which provide for ventilation (which is essential for habitability) and the possibility of cooking Two types of urban caves can be found in the city The first are the ‘coves afrontades’ which present a façade much like a regular house and the others are ‘coves enclotades’ which surround a common courtyard without having access to a regular street and The cave dwellings need to be whitewashed with lime once or twice a year such whitewashing is included in the announced renovations which began last week and are expected to continue for 3 or 4 weeks through its ​​Historical Heritage Department and together with the public company Gestión y Servicios de Paterna is ensuring the repair and improvement works of the facades skylights and chimneys of the municipal caves-dwellings many of which are integrated into the surroundings of the city Tower If you want to keep up with how European cities and regions are changing, follow us on Facebook, Twitter and Instagram The 10th European Conference on Sustainable Cities and Towns (ESCT) sets the stage for stronger cooperation between the EU national and local level to fast track Europe's transition to climate neutrality Urban dwellers across the EU are having a say in making their surroundings friendlier to people and the environment Forests in the EU can help green the European construction industry and bolster a continent-wide push for architectural improvements Apply by 10 November and do your part for the transformation of European public spaces An interview with the Mayor of a Polish city that seeks to reinvent itself An interview with the newly elected ICLEI President and Mayor of Malmö A conversation with the Mayor of Lisbon about the spirit and dimensions of innovation present in the Portuguese capital Please enable JS and disable any ad blocker A mini VCF World Cup will be held at the Ciutat Esportiva in Paterna The Valencia CF Academy is already preparing the second edition of the VCF Academy World Cup which will take place from 29 June to 2 July 2023 with a representation of teams from America Valencia and the Ciutat Esporta de Paterna will host hundreds of young players under 12 years of age from all over the world to enjoy football and participate in this second edition of the VCF Academy World Cup for a week aiming to repeat and improve the great experience of 2022 "The idea is to consolidate the VCF Academy World Cup as an international reference and make it an event where every season the different VCF Soccer Academies that we have around the world as well as other clubs and academies linked to the VCF Academy Programs come together," explained those in charge of the VCF Academy Programs "Last season's experience was incredible because of the atmosphere that was generated the training camp in the buildup to the tournament the cultural exchange between players and coaches the entertainment provided by family members during the days of competition and above all the footballing performance displayed by every team The teams participating in this II VCF Academy World Cup are already booking their places to take part in the tournament and in some cases also to carry out the full training camp at the Ciutat Esportiva de Paterna with training sessions as well as visits to Mestalla and cultural experiences in the city of Valencia "Most of the academies have already confirmed that they are going to repeat in this II VCF Academy World Cup and this edition we will have new ones who want to live this experience for the first time" Africa and Asia will enjoy a great football atmosphere and will face an unforgettable experience that has led several of the teams and players to want to repeat their presence in the VCF Academy World Cup which in its first edition had FK Zalgiris Kaunas as the winner in a first edition that had 10 teams and a competition system with 60 matches marked by VCF DNA The aim of this second edition is to repeat the great atmosphere experienced both at the Camp de Mestalla and at the Ciutat Esportiva de Paterna to ensure that every team and every player enjoys a great football experience and to improve the small aspects of the tournament so that it can grow edition after edition in terms of quality and exposure  This is how the I edition of the VCF World Cup unfolded: https://www.valenciacf.com/en/article/en-i-vcf-academy-world-cup-a-great-success-2022-06-27 The I VCF Academy World Cup, a competition full of excitement, emotion and learning: https://www.valenciacf.com/en/article/en-the-i-vcf-academy-world-cup-a-competition-full-of-excitement-emotion-and-learning-2022-07-01 The main objective of the VCF Soccer Academy Programs in addition to expanding the brand of Valencia CF and its philosophy around the world is to take the training methods of Valencia CF to any part of the planet and promote the values that always go hand in hand with this Club making the participants enjoy and learn from the best professionals of the Valencia CF Academy one of the best in Europe according to the latest reports of the CIES Football Observatory the VCF Soccer Academy and the Sports Consultancy services are just some examples of this great project - More information HERE Juan Sagredo is an engineer born in Paterna He has worked since 2001 in Ferrocarrils of the Generalitat Valenciana He has studied at the Polytechnic University of Valencia receiving his final degree from the University of Bristol Member of the Spanish Socialist Workers Party (PSOE) Sagredo has been Mayor of the city since June 2015 the industrial engine of the province of Valencia and one of the most important business enclaves in Europe It also has a rich historical and cultural heritage characterized by the Moruna Tower and the caves declared a festival of national tourist interest in 2017 a fixture in which more than 70,000 rockets will be fired in less than 20 minutes in just 100 meters from the street One of our challenges is to turn Paterna into an intelligent sustainable and integrated city to be at the forefront of the future continue to grow and improve the quality of life of our inhabitants in the hands of innovation and always with sustainability as the fundamental axis of our management This distinction places Paterna at the national forefront in terms of business innovation technological and innovative potential of its institutions and companies and represents a further step in the promotion of R & D & I in our territory to improve the social well-being and the quality of life of the citizens Paterna is an eminently industrial city that stands out nationally and internationally for having five business parks The Technology Park is one of these five areas Paterna has made history by becoming the first city in Spain to adapt to the Law of Industrial Areas and will serve as an example for the rest of municipalities that seek to boost their business areas the Paterna Technology Park achieves a pioneer management model at the national level that will strengthen the public-private collaboration of this business area making it possible to improve the management modernization and promotion of the business area Job creation is one of the pillars of our government's political management along with security and cleanliness These are the three things that most demand and concern our citizens we have oriented our policies to favour business dynamism we have signed economic agreements between the City Council and all our business areas we encourage entrepreneurship and the creation of local employment with economic aid called Entrepreneur Check and Employment Check and we favour the constant arrival of new economic activities in the business areas of Paterna and the expansion of the companies already installed All these have allowed us to continue with the constant trend of reducing unemployment in our city The Guardian Project is an innovative project which we are carrying out jointly with the city of Riba-Roja and which is based on reusing purified water to prevent fires The Guardian project is a clear example of Paterna's commitment to sustainable development and the fight against climate change Guardian actively contributes to goals connected with access to water and sanitation climate action and sustainable communities and cities We have put the investigation at the service of our neighbours of the Parc Natural del Túria the security against the risk of forest fires at the same time that we make efficient use of a scarce resource such as water In Paterna we base our management and the orderly and sustainable growth of our city on the Actua Plan the urban development strategy co-financed by the EU Funds and the City Council of Paterna with which the municipality will receive an injection of 20 million euros The Plan Actúa contemplates the improvement of the safety of the level crossings and the conservation of the paternal cultural heritage the creation of pedestrian living areas or the remodelling of public park equipment as well as the urbanization and recovery of the most degraded neighbourhoods The objectives of this plan also include the improvement of access to new technologies facilitating connectivity to all citizens; energy efficiency with the installation of photovoltaic panels on roofs of buildings and public facilities and social inclusion with the creation of a coworking centre or a business revitalization plan torna il campionato con le partite della 30esima giornata l'Inter di Simone Inzaghi affronterà l'Udinese gara che sarà diretta da Daniele Chiffi della sezione di Padova che godrà dell'assistenza di Rossi e Fontemurato In sala VAR ci sarà invece Paterna con Pezzuto come assistente sarà Simone Sozza a dirigere Napoli-Milan COMO – EMPOLI     Sabato 29/03 h.15.00 VENEZIA – BOLOGNA     Sabato 29/03 h.15.00 LECCE – ROMA     Sabato 29/03 h.20.45 INTER – UDINESE     h ACQUISTA QUI I PRODOTTI UFFICIALI INTER! Add your event. - Two men charged with illegally cutting and removing trees from a Riviera neighborhood in Santa Barbara were in court Monday for their arraignment.  James Allen Carr and Enriquez Calles Vasquez both pleaded not guilty to two felony counts of vandalism and four misdemeanor counts.  The incident happened back in December of 2020 on Paterna Road Prosecutors allege Carr hired Vasquez and a crew to chop down four mature Eugenia trees on or near Carr's newly purchased property It's estimated the trees were more than 50 years old; three were owned by the city Seven months later neighbors are still up in arms who live right across the street from Carr "It's really hurt our privacy," Malki told NewsChannel 3 anybody at that house can look directly into our master bedroom Malki was there the day the trees were chopped down and taken away He said he asked the workers to stop so he and other neighbors could talk to Carr about the situation first Park rangers also responded, telling the crew a permit was needed.  Neighbors told NewsChannel 3 Carr put the home on the market within two months after the tree cutting incident Many believe the Elk Grove man intended to "flip" the property all along. Eventually One large Eugenia tree still stands out front to the left of the house "He left this one which is equivalant to the size of the other ones because it blocks his view to the telephone pole," said Malki Malki said he and Carr have never spoken.  NewsChannel 3 reached out to Carr on Monday Beth Farnsworth is the evening anchor for KEYT News Channel 3. To learn more about Beth, click here News Channel 3-12 is committed to providing a forum for civil and constructive conversation Please keep your comments respectful and relevant. You can review our Community Guidelines by clicking here If you would like to share a story idea, please submit it here Terms of Service Privacy Policy Community Guidelines FCC Public File EEO Public File Report FCC Applications Do Not Sell My Personal Information Looking to access paid articles across multiple policy topics Interested in policy insights for EU professional organisations Some Sicilian companies in the agri-food sector have chosen a different model of producing and selling The idea is to recover the “human” contact with the product and with the consumer EURACTIV’s partner Sicilia Agricoltura reports Valdibella's cooperative celebrates this year its twentieth birthday. After Italy, Belgium is the country where Valdibella exports more products. Paterna Bio exports the iconic Sicilian lemon all over Europe. [OSSINO/SHUTTERSTOCK] The Common Agricultural Policy is key in ensuring that farmers receive a steady but imbalances in the food supply chain risk undermining farmers as well as consumers Farmers in France are seeking growth through direct sales targeting a burgeoning market in local produce The development of short food supply chains – where intermediaries between farmers and consumers are removed – should result in fairer remunerations for farmers and higher quality local food products Sign up here for your daily business digest direct to your inbox Sign Up Discover our talented editorial team and the principles that drive them. Intuita’s Latest Senior Hire Joins From KPMG To Lead New Data Excellence Practice Intuita, one of the UK’s leading data solutions and analytics providers, has announced that Sofia Alcala Paterna has joined the company as Data Excellence Practice Director, from KPMG, to lead the firm’s new Data Excellence Practice. She will be responsible for defining and growing the Practice and contributing to the evolution of the new business capability to support clients’ expanding enterprise data requirements. Sofia, who was previously Data Governance and Strategy Lead & Deputy Chief Data Officer, KPMG, brings a wealth of Data and IT Strategy leadership experience from her previous roles. Prior to KPMG, she was Data Governance and Strategy Lead at PwC and Head of Data Governance at MBNA. The Practice will help organisations to assess gaps and opportunities within their existing data ecosystem and create strategies that ensure the required operating models, processes and technologies are embedded throughout. The aim is to ensure businesses can reach a level of data maturity and have a culture of data whereby data is intrinsic to decision making at all levels of the organisation. In previous roles, Sofia worked on major enterprise data project programmes, such as: leading the successful migration of ten different customer databases involving complex target architectures; implementing CDO capabilities across three different organisations at both market and global level; and the successful delivery of data reconciliation solutions, minimising lost revenue and regulatory penalties. Sign up to receive our popular morning National email for free. 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Sign inorRegisterWorking in a restaurant can be many things: exciting a little hectic!Those who've worked in restaurants all their life will often tell you there's no other job like it and you get to talk to lots of different people and make sure they have a great experience So what does it take to succeed in the hospitality sector who manages the Union Street Café by Gordon Ramsay to give us his top tips on having a fulfilling career in his industry Roberto is one of the employers featured in Stacey Dooley's new programme The Nine to Five manager of Gordon Ramsay's Union Street Café gives his top tips on working in hospitality I am the general manager of Union Street Cafe I started hospitality when I was about 15 years old I was always smiling and babbling and joking with everybody and now I manage a team of about 45 amazing people And come to Papa if needed!" [Laughs] My top tips for young people that want to come into the hospitality wards You really need to understand the layers of Proud of what you will do." "Ahh." We do have lots of people with experience around us And let you become the talented individual that you eventually want to become Without my team I would not be able to be where we are The small details make the experience from average to memorable it's a job that you can really have a career path and it's a job that gives you immense satisfaction I highly recommend people to explore the hospitality business it's an amazing industry to be part of videoWhat skills do you need to work in care one of the employers from The Nine to Five with Stacey Dooley talks about what it takes to work in the care sector Watch The Nine to Five with Stacey Dooley on iPlayer Advice from the people who've found the right path for them