It is with deep sadness that we announce the passing of Veronica Renee Adams-Santaella
by Ariana St Pierre
Maine (WGME) -- Police say three people from New York stole over-the-counter medications and beauty products from a Hannaford in Brunswick
The trio is accused of taking part in a massive retail theft operation
Employees at the Hannaford on Elm Street called police after they saw 29-year-old Marlene Santaella
24-year-old Angie Cubillos and 38-year-old Alan Rodriguez stealing large amounts of over-the-counter medications and beauty products on Wednesday
according to the Brunswick Police Department
Police say they found the suspects in a vehicle not far from the store
officers found approximately $32,000 worth of over-the-counter medications and merchandise inside the vehicle
They are suspected of participating in an organized retail theft ring and had victimized other stores in Maine
and each suspect was charged with theft by receiving stolen property and theft by unauthorized taking or transfer
Rodriguez and Cubillos were also wanted for allegedly committing similar crimes in California and New Jersey
They were additionally charged as being fugitives from justice
The trio was taken to the Cumberland Count Jail
Rodriguez and Cubillos are being held without bail
Celebrating community and volunteerism at the Brazilian Consulate
Alberto Pineda Santaella is a Research Fellow in the Randall Centre for Cell & Molecular Biophysics
We caught up with Alberto to learn about his research on cell division and his favourite part of working in the lab
tell us about your background and career up to this point
earning my degree and Master’s in Sanitary Biotechnology from Pablo de Olavide University in Seville
My PhD research at the University of Salamanca focused on how cells divide in fission yeast (Schizosaccharomyces pombe)
After working in functional genomics with budding yeast (Saccharomyces cerevisiae) in Barcelona
where I study a unique type of cell division in another fission yeast species (Schizosaccharomyces japonicus)
What advice would you give to your 18-year-old self
Do you have any current projects that you’d like to tell us about
I’m currently learning game development and learning Japanese by self-teaching
Where do you see yourself in five years’ time
I would like to consolidate my scientific career during my postdoc stage
continuing working on basic research on diverse aspects of cell division in simple yet powerful systems such as yeast
I’m also open to branching out to other model organisms to validate my findings and transitioning into applied research when opportunities arise
What is something positive that happened to you over the last year
I am profoundly happy to have been granted the Marie Skłodowska-Curie grant
This is very good news for the lab and for my financial support for the next years
Due to the huge amount of work and professional and personal dedication that it involves
I would say that writing and defending my thesis has been my biggest success
I enjoy the flexibility and independence in organising my schedule and tackling the biological challenges that arise daily in the lab
Netflix recommendation: The three-body problem (series)
Describe yourself in three words… methodical
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+44 (0)20 7836 5454
Springfield Police Department
— On Tuesday August 20th at approximately 7:30 p.m.
members of the Springfield Police Firearms Investigation Unit under the direction of Sergeants Christopher Hitas and David Robillard seized an illegal loaded firearm and made three arrests in connection with drug dealing in the Wilcox Street area
For the past several months Detectives have been investigating illegal drug activity on the 0-100 block of Wilcox Street
Detectives were conducting surveillance in that area when they observed a drug transaction
Shortly thereafter Detectives activated their emergency lights and stopped a suspect
Detectives were able to get the car to stop on the 0-100 block of Chestnut Street
Detectives recovered heroin from Allaire and an illegal loaded firearm from Santaella
Santaella has previously been convicted of illegal firearms and drug distribution charges
29-year-old Rafael Santaella of Springfield is charged with:
32-year-old Kyle Allaire of Chicopee is charged with:
Copyright © 2025 Springfield Police Department All rights reserved. • Site Design by John Guilfoil Public Relations, LLC
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Accurate gametogenesis requires the establishment of the telomere bouquet
telomeres temporarily aggregate at the nuclear envelope during meiotic prophase
which facilitates chromosome pairing and recombination
The mechanisms governing the assembly of the telomere bouquet remain largely unexplored
primarily due to the challenges in visualizing and manipulating the bouquet
using Schizosaccharomyces pombe as a model system to elucidate telomere bouquet function
traditionally perceived as playing a passive role in the chromosomal reorganization necessary for bouquet assembly
play a key role in the initiation of telomere bouquet formation
We demonstrate that centromeres are capable to induce telomere mobilization
which is sufficient to trigger the first stages of bouquet assembly and the meiotic transcription program in mitotic cells
This discovery highlights the finely tuned control exerted over long-distance heterochromatic regions and underscores a pivotal step in the mechanism of eukaryotic telomere bouquet formation and meiotic transcriptional rewiring
understanding the transition in chromosome architecture from interphase to meiotic prophase poses a challenge
given its swift nature and difficulties in observing and manipulating it
This model system enables dynamic tracking of specific loci in chromosomes
centromeres and telomeres throughout mitosis and meiosis
alongside the manipulation of the Rabl conformation and the telomere bouquet
a Schematic representation of the centromere-SPB interaction in fission yeast
b State of the interphase centromere (Mis6-GFP)-SPB (Ppc89-CFP) interaction in Rabl and Rabl-deficient (sad1-2 csi1Δ) cells; the nuclear envelope (NE) was visualized by Ish1-mRFP
c Flow diagram of the synthetic genetic analysis used to screen for genetic interactors of sad1-2 csi1Δ
d Selected gene interaction data after filtering non-differential phenotypes
between wt (control) and sad1-2 csi1Δ settings (27 out of 2,988)
The colony growth rate was analyzed using hierarchical clustering with Euclidean distance and the complete linkage method to identify gene clusters (two-sided p value < 0.001
e Representation of the role of each analyzed chromatin anti-silencing factor in the regulation of centromeric
dismantling the telomere-SPB association and initiating the first meiotic division
little attention has been given to the role of centromeres in initiating the formation of the telomere bouquet
as it is believed that they do not participate in the initial signals that mobilize the telomeres to form the bouquet
we have uncovered the presence of a long-distance signal originating from centromeres to telomeres
We demonstrate that sad1-2 csi1∆ cells initiate bouquet formation and activate the meiotic program in mitotic cells
This can be attributed to the loss of centromere-SPB interaction
as these phenotypes can be rescued by restoring this interaction
a signal exists between two specialized chromosome regions
spatially separated in distinct microenvironments inside the nucleus
to coordinate the initiation of bouquet formation
Considering the widespread conservation of centromere clustering during mitosis and telomere bouquet formation during meiosis in eukaryotes
our results provide insights into the fundamental orchestration of bouquet assembly and
the control of the initiation of meiotic differentiation
which likely affects proper chromosome segregation
The above analyses suggest that cells without proper Rabl chromosome configuration display chromatin silencing defects which must be alleviated by anti-silencing factors such as the Set1/C complex
The p value from one-sided binomial test analysis is shown
d Table of the most upregulated meiotic-specific genes from previous RNA-seq data
e Plot of reads-per-million (RPM)-normalized read density at the indicated loci
Individual signals for each biological replicate are shown in a lighter color
and the average of these is shown in a darker color
f RT-qPCR analysis of relevant meiotic-specific genes showing RNA levels relative to wt after normalization to act1+
Data are represented as mean ± SEM from 3 independent experiments; the numbers above the columns represent p values from two-tailed Student’s t-test analysis
Source data are provided as a Source Data file
All these data revealed that the disconnection of centromeres from the SPB serves as an unexpected trigger for the activation of the meiotic transcriptional program
remain relatively unaffected when centromeres are disconnected from the SPB
pombe subtelomeric and telomeric regions of chromosomes I and II
showing the shelterin domain (pink triangle)
heterochromatic domain (purple semicircle)
The locations of the primers used are shown with red lines
b RT-qPCR analysis of proximal subtelomeric regions of chromosomes I and II showing RNA levels relative to wt after normalization to act1+
tlh1+ and tlh2+ are located on the left and right arms of chromosomes I and II
c RT-qPCR analysis in distal subtelomeric regions of chromosomes I and II
data are represented as mean ± SEM from three independent experiments in all cases
which were conducted with four independent experiments
The numbers above the brackets represent p values from two-tailed Student’s t-test analysis
d Plot of reads-per-million (RPM)-normalized read density at the indicated loci
a Representative pictures of two-color live-cell imaging of control
csi1Δ and sad1-2 csi1Δ strains during interphase
The telomeric protein Taz1 is visualized in green (Taz1-GFP)
while the NE is shown in magenta (Ish1-mRFP)
b Quantification of telomere foci in the indicated strains
c Representative pictures of two-color live-cell imaging as in (a)
d Quantification of cells with number of telomere foci in the indicated strains
e Zone designation (I-III) and distribution of telomeres within 15 confocal planes with illustrative pictures (scale bars
f One z plane of live-cell imaging of control
sad1-2 csi1Δ and lem2Δ strains during interphase
g Quantification of telomeres (Taz1-GFP) distribution relative to the NE
showing the percentage of telomeres for each nuclear zone
d and g) were collected from three independent experiments
and the one-sided p values from the χ² test analysis are shown above the brackets
the crucial distinction in telomere mobilization along the NE observed when manipulating centromere positioning unveiled a qualitatively different phenotype from previous observations that is characterized by the highest penetrance of telomere declustering yet steadfast telomere-NE associations
as demonstrated during the first stages of the meiotic cycle
a GFP-GBP system used to force the interaction between Sad1-2 and Ndc80
b Serial dilutions (5-fold) of log-phase cultures of the indicated strains spotted onto YE4S plates containing MBC or TBZ and incubated at 32 °C for 48 h
d Data were collected from three independent experiments
Data are represented as mean ± SEM from three independent experiments; p value from two-tailed Student’s t-test analysis is shown above the brackets
Colony growth rate was analyzed using hierarchical clustering with Euclidean distance and the complete linkage method to identify gene clusters (two-sided p value < 0.001)
This indicates that manipulating centromere positioning alone can enable telomeres to recruit bouquet proteins and initiate at least partial telocentrosome formation
we did not observe complete formation of the telomere bouquet
where all three telomeres associate with the SPB in mitosis
The most likely explanation is the absence of the characteristic nuclear movements driven by dynein that occur during meiotic prophase and are essential for bouquet formation in meiosis
we did not detect Dhc1 in mutant conditions
suggesting the absence of these motor proteins under our experimental conditions
these findings suggest that alterations in centromere positioning act as a prelude
preparing chromosome ends for the moving from their mitotic location to the SPB along the NE and thereby facilitating the formation of the telomere bouquet
suggesting that the growth defects in sad1-2 csi1∆ cells are
these findings support the hypothesis that loss of the centromere-SPB interaction triggers the initiation of differentiation
a-b Frames from time-lapse experiment of meiotic diploid cells expressing endogenously tagged Ndc80-GFP and Taz1-mCherry
c Quantification of Ndc80-GFP intensity throughout the experiment as depicted in panels (a) and (b)
with each color representing the behavior of 9 independent cells
d Meiotic diploid cells were analyzed as in (a-b)
but with one copy of Sad1 endogenously tagged with GBP
e-f Exponentially growing diploid cells were induced to undergo meiosis
The percentage of cells with the indicated number of nuclei per cell is shown for 200 cells at each time point across three independent experiments
g Frames from a time-lapse experiment of meiotic diploid cells with endogenously tagged Cdc2-GFP and Taz1-mCherry
Yellow arrows indicate early and late co-localization between telomeres and Cdc2
h Quantification of Cdc2-GFP intensity throughout the experiment as depicted in panel (g)
with each color representing the behavior of 7 independent cells
These results suggest that communication between centromeres and telomeres might involve a chemical signal released from the centromere to the telomeres
These observations led us to explore Cdc2 in mitotic cells upon the disruption of the proper Rabl chromosome configuration
g–h A similar strategy to that in (d) was used to direct the Cdc2 chimera to the SPB via Sad1-2-GFP in csi1∆ cells
with endogenous tagging of mis6-mCherry or taz1-mCherry to visualize and quantify centromere and telomere behavior
Controls in (g) and (h) represent wild-type cells carrying sad1-GFP mis6-mCherry and sad1-GFP taz1-mCherry
Scale bars: 5 μm (full images) and 2 μm (single-nucleus windows)
One-sided p value from χ² test analysis is indicated above the brackets
This strongly suggests that long-distance communication from centromeres to telomeres
necessary to initiate telomere bouquet formation
might be mediated by the trafficking of Cdc2 molecules from centromeres to telomeres within the nucleoplasmic environment
these findings reveal an unexpected communication between two distinct specialized regions of the chromosomes
enabling a precise transition of the 3D chromosome conformation
This communication allows centromeres and telomeres to interchange positions
The consequences of these premature activation of several meiotic genes and the chromosome architecture likely result in Rabl-deficient cells having severe problems in normal meiotic entry upon nitrogen starvation (Supplementary Fig. 2d)
it could be interesting to combine the loss of the Rabl chromosome configuration with the ectopic recreation of strong nuclear movement in mitosis
Current studies in our lab aim to develop this system
Working model for telomere bouquet formation upon meiotic entry: i) During mitotic interphase
fission yeast cells display a conserved Rabl chromosome configuration
centromeres are positioned beneath the SPB thanks to the interaction between the LINC complex (Kms1/2-Sad1) and the kinetochore complex (inner and outer kinetochore)
based on the interaction between the Bqt3-Bqt4 complex and the Rap1-Taz1 complex
centromeres decluster from the SPB as the outer kinetochore disassembles
a process that may require a decrement of Cdk1 activity in the outer kinetochore region to facilitate centromere detachment
Cdc2/Cdk1 may be recycled and mobilized to the telomeres to promote their declustering
telomere declustering facilitates their movement towards the SPB and the recruitment of bouquet proteins
centromere dissociation from the SPB is a prerequisite for telomere-SPB interaction
thanks to the recruitment of bouquet proteins (Bqt1 and Bqt2) to the LINC complex with the aid of the Bqt3-Bqt4 complex
iv) Bouquet formation occurs when centromeres are completely dissociated from the SPB
based on the interaction between the LINC complex and the Rap1-Taz1 complex
which depends on the bouquet proteins (Bqt1 and Bqt2) and is aided by the Bqt3-Bqt4 complex
our data strongly suggest that centromere positioning plays a crucial role in initiating the bouquet formation process and likely serves as the primary factor triggering the onset of the meiotic program
Due to the high conservation of the telomere bouquet in plants
the identification of a long-distance signal from centromeres to telomeres as a controller of meiosis reveals an additional layer of regulation orchestrated by the centromere positioning for the meiotic program in eukaryotes
experiments were performed with haploid cells
that were usually grown in rich media (YE4S) at 32 °C or EMM2 media at 32 °C until exponential mid-log phase
Final concentrations of aureobasidin A (0.5 µg/mL) (ClonTech)
nourseothricin (100 µg/mL clonNAT) (Werner Bioreagents)
G418 (100 µg/mL geneticin) (Invitrogen) and hygromycin B (300 µg/mL) (Invitrogen) were added for selection purpose
Strain crosses and sporulation were performed in sporulation agar (SPA) plates at 28 °C
and genetic dissection was performed using a dissection microscope (MSM 400; Singer Instruments)
Meiosis progression and efficiency assays were carried out in sporulation agar (SPA) plates at 28 °C during 48 h incubation
at least 300 meiotic cells were quantified
Diploid strain in Fig. 7 were initially grown in liquid YE during at least 4 generation times
cells were transferred to EMM with supplements at OD600 = 0.02 and incubated overnight at 28 °C
washed twice with MM-N low glucose (0.5% Glucose)
inoculated in the same medium and incubated at 28 °C for 4 h before time-lapse acquisition
Genetic interactions of triple mutants were analyzed based on colony size (area) as a readout of cellular fitness
searching for biological process or gene expression pattern
Strains were grown in YE4S to exponential midlog phase (1 × 107 − 1.4 × 107 cells/mL; OD600 = 0.5–0.7) at 32 °C
and 5-fold serial dilutions were spotted onto YE4S plates containing DMSO or YE4S plates containing different concentrations of MBC (carbendazim
The plates were incubated at 32 °C for 48 h
at 300 dpi resolution in and Epson scan (Epson scan v
3.04E) and tiff images were cropped using Adobe Photoshop CS5 Extended for representation purpose
Quantification of telomere declustering was conducted in mononucleated cells
identified by the presence of a single SPB when possible or confirmed by FACS analysis
Signal quantification of Taz1 and Rap1 was carried out using Fiji software on images captured across 15 focal planes
The intensity of each area containing a given signal was measured
and the intensity of a signal-free region within the same cell was subtracted
The resulting signal intensities were normalized to the average intensity per pixel in the background outside the cell
For experiments to rescue telomere foci formation using the GBP-GFP system in exponentially growing cells (Fig. 5)
a Zeiss Axio Observer 7 inverted microscope was used
with Zeiss Plan-Apochromat 63x/1,40 Oil DIC and Alpha Plan-Apochromat 100x/1,46 Oil DIC lenses
coupled to Spinning Disk Confocal Yokogawa CSUW1 head with excitation lasers and filters from 3i (Intelligent Imaging Innovations)
SlideBook 6 software was used for device control and image capturing
cells collected by centrifugation and immobilized to 35 mm glass culture dishes (Ibidi) using 0.2 mg/mL soybean lectin (1 mg/ml
Sigma-Aldrich) and immersed in EMM2 (with required supplements)
Live-cell imaging was carried out at 32 °C in an environmental chamber for temperature control under the microscope
Images were acquired over 15 focal planes at a 0.4 μm step size
All images were processed using the open Image J software
Presented images correspond to combined maximum Z-projections
We assessed the overrepresentation of differentially expressed features at specific genome locations via positional enrichment analysis with the PGE tool (REF: PMID18346969)
This tool tests the enrichment of a set of query genes at chromosomal regions of any width
The number of genes found at a specific location is modeled as a hypergeometric distribution
The gene annotation and coordinates of the S
pombe genome were restricted to the genes detected by RNA-seq and fed into PGE as the reference dataset
the list of genes passing the filtering criteria for the RNA-seq analysis (abs(log2FC) > 0.5 and p-value < 0.05) were fed into PGE
The threshold for significance in the positional analysis was set to p-value < 0.05
for upregulated and downregulated genes from the RNA-seq analysis
shinyCircos 2.0 (REF: 10.1002/imt2.109) was used to generate the visualizations of RNA-seq and positional enrichment statistics
The mean of data from 3-4 independent biological replicates are shown as relative to the mean value of the control (which was set to 1)
Multiple two-tailed Student’s t-test analysis was performed using ANOVA followed by a Tukey’s post hoc test at a 0.05 significance level using GraphPad Prism software (Dotmatics)
Samples of interphase cells were obtained from 10 mL of exponential growing cultures at OD600 = 0.5 at 32 °C
Cells were collected by centrifugation at 4 °C and cellular pellets were flash frozen in liquid nitrogen and stored at -80 °C until use
The secondary antibody was horseradish peroxidase (HRP)-coupled anti-mouse IgG (Sigma-Aldrich)
Visualization was performed using the SuperSignal WestFemto Maximun Sensitivity Substrate (ThermoFisher) in a Chemidoc MP Imaging System (Biorad)
Images processing for representation was performed using Adobe Photoshop CS5 Extended
signal quantifications were performed in ImageJ and a two-tailed Student’s t-test analysis was performed at a 0.05 significance level using GraphPad Prism software (Dotmatics)
107 cells from exponentially growing cultures (OD ~ 0.3–0.4) were centrifuge at 1000 × g for 5 min
and the tubes were vortexed (cells could be stored indefinitely at 4 °C)
300 µL (~ 2–3 ×106 cells) were transferred to 1 mL of 50 mM Na citrate in an eppendorf tube
the pellet was resuspended in 0.5 mL 50 mM Na citrate containing 0.1 mg/mL RNase A
Samples were then incubated at 37 °C for at least 2 h (or overnight if needed)
samples were centrifuged at 1000 × g for 5 min
each pellet was resuspended in 1 mL 50 mM Na citrate containing 4 µg/mL propidium iodide
Samples were either processed immediately by sonicating at 50% amplitude for 10 s to separate cells or stored overnight at 4 °C in the dark for processing the next day
The settings used in the FACS Calibur cytometer were as follows: detector FSC E00 Gain:3; Detector FL2-A Voltage: 890 Gain: 2
Micrographs of representative images, as shown in Figs. 1b, 4e, and 8c, d
were obtained from three independent experiments
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article
The RNA-seq data generated in this study have been deposited in NCBI’s Gene Expression Omnibus under GEO Series accession number GSE252561. Source data are provided with this paper
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We thank all lab members for their critical comments on the manuscript and express our gratitude to all participants of the IBFG and CABD seminars for their valuable input
Special thanks to Matías Capella for his support with the SGA experiment
Víctor Álvarez Tallada for his support in managing the logistics of the CABD's transition to the IBFG
and to the Shiv Grewal lab for providing the script for (RPM)-normalized read density plots
we express our gratitude to INLEXIO for English grammar corrections and to the NBRP resource in Japan for providing strains
This work was supported by PID2021-127232NB-I00 funded by the MCIN/ AEI /10.13039/501100011033 and by the “FEDER
AJ-M was funded by Juan de la Cierva Formación 2020 Grant FJC2020-046386-I; AT was supported by the EUR G.E.N.E
(reference #ANR-17-EURE-0013) and is part of the Université Paris Cité IdEx #ANR-18-IDEX-0001 funded by the French Government through its “Investments for the Future” program
was supported by PID2021-1284080B-I00 funded by MCIN/ AEI
The IBFG is an institution funded by the Salamanca University and Consejo Superior de Investigaciones Científicas (CSIC)
Instituto de Biología Funcional y Genómica
Sergio Camacho-Cabañas & Alfonso Fernández-Álvarez
Max-Delbrück-Centrum für Molekulare Medizin
Berlin Institute for Medical Systems Biology (BIMSB)
Biology of Centrosomes and Genetic Instability Team
Departamento de Biología Molecular e Ingeniería Bioquímica
contributed to the validation of SGA genetic interactions
wrote the manuscript with significant input from R.R.D
The authors declare no competing interests
Nature Communications thanks Kayoko Tanaka and the other
reviewer(s) for their contribution to the peer review of this work
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
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SearchVideo gaming operators call for protest on inauguration dayThe San Juan Daily StarNov 14
20241 min readThe island’s video gaming machine operators have called for the resignation of Puerto Rico Gaming Commission Executive Director Juan Carlos Santaella Marchán.By The Star Staff
Video gaming machine operators are planning a mass protest for governor-elect Jenniffer González Colón’s inauguration ceremony
The operators have called for the resignation of Puerto Rico Gaming Commission Executive Director Juan Carlos Santaella Marchán
the coordinator of video game machine operators for the northern region of Puerto Rico
asked González Colón and her campaign manager
to take steps to stop the intentions of the Gaming Commission and the Horse Racing Board to increase to 15 terminals the number of slot machines for the horse racing agencies of Camarero Racetrack
which they said do not contribute a single cent to the island Treasury
the more than 1,500 gaming machine operators
family members and clients will be called to a protest that will take place on inauguration day
Villafañe Fernández stressed the call for the resignation of Santaella Marchán
who he said “is openly paving the way to maintain ties with the administration of Camarero Racetrack
hold public hearings to approve nearly 5,000 new terminals to install more slot machines at horse racing agencies
whose operation and prizes do not pay taxes to the Treasury Department.”
his appointment to a position in the government should never be considered,” he added
© 2025 The San Juan Daily Star - Puerto Rico
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By: Sebastian Morris 7:30 am on March 18
Acacia Network and Phipps Houses recently celebrated the grand opening of Santaella Gardens, a 249-unit affordable housing property in the Soundview section of The Bronx. Located at 1230 Metcalf Avenue
available homes are reserved for individuals and households earning between 30 percent and 90 percent area median income (AMI)
as well as 25 units for the formerly homeless
Santaella Gardens is named in honor of Justice Irma Vidal Santaella
the first Puerto Rican woman to serve as a Justice of the New York Supreme Court
The developers were joined by local community groups
and the Santaella family for a ribbon-cutting ceremony at the new building
“The path to a truly affordable city requires us to build high-quality affordable housing that serves all communities,” said Adam Weinstein
“Our partnership with the Acacia Network at Santaella Gardens has created much needed affordable housing in The Bronx
including units for the formerly homeless.”
Roof terrace at Santaella Gardens – Dattner Architects
Children’s playroom at Santaella Gardens – Dattner Architects
Led by Dattner Architects, the 12-story building was designed to meet Passive House sustainability standards
This means that the structure incorporates a high-performance façade to mitigate heat loss or heat gain
which typically drives up energy costs related to internal temperature control
The building will also feature energy-efficient lighting systems and mechanical components
Energy Star-rated appliances in each apartment
Amenities include an 11th floor amenity deck with a fitness center
something that Justice Irma Vidal Santaella
fought for her entire career,” said Bronx borough president Vanessa L
“This 100-percent affordable housing development will bring 249 much-needed units for low- and moderate-income households
along with 25 units for the formerly homeless to the Soundview section of The Bronx
This affordable housing project represents important investments that should be a model for our borough and city.”
Subscribe to YIMBY’s daily e-mail Follow YIMBYgram for real-time photo updates Like YIMBY on Facebook Follow YIMBY’s Twitter for the latest in YIMBYnews
Affordable housing development will bring 249
much-needed units for low- and moderate-income households
Along with 25 units for the formerly homeless
I’m happy to see creating happiness for people; who don’t have a chance to be comfortable: Thank you
Yes yes i like it how can i get an application to one of these my appartment
Hi I would like to apply for 1230 Metcalf Avenue I would like to have an application I got a Section 8 voucher with $1,900
Will the apartments be for people who are no SSI,SSD how only get that money ever monthly.What do you call low income please
I texted earlier I will love to apply.if I can
Hi my name is the noel padilla and I’m interested in a one-bedroom apartment I got a Section 8 voucher was 2,218 can you please tell me what I have to do to get an application thanks have a blessed day.
To whom it may concern I apply on housing connect at the time I was working for sebco/housing but thing turn my income change now I received ssi/sad and retire because my health I hope someone put my file because I never got a call or letter from you
Rumor has it that a post on this building once got a ballistic amount of comments…
Hi my name Jacqueline Davis can you send me a application Upcoming Apartments 🏠 Thank you so much I need two bedroom unit going to give you my address 12-50 35Th Ave Astoria New York 11106 apt 2G
I really need an application for two bedrooms or even one bedroom…I work full time My address is 669 Cauldwell ave apt
4B Bronx NY 10455 Really appreciate if I can get an application…really I need of an apartment with elevator…have artritis in both knees.
Please send me an application…THANKS🙏❤
I need an application my landlord is selling the house
I work can’t find affordable apartments
Hello apply before the building was building construction
currently a senior on Disability income and Section 8 Voucher
Apply on Housing Connect low income housing
Good morning just retire looking for a new apartment to live in
am currently employed and I have a feps voucher
I’ve been looking for a place to move for months
Good Afternoon I would like a application for a two bedroom thank you
Hello I am a Senior Citizen who is disabled I receive Social security Disability and I really need to find a nice place where to live can you Please send me an application for a one bedroom apartment just for me my cell phone number is 1-646-973-0813
I am unable to work at this moment I am 63 this is Miriam ruiz again I’m just trying to give you the right information I live in Yonkers New York but I’m willing to move to the Bronx if you could help me
OF 15LLOYD STREET BROOKLYN NEW YORK 11226 PHONE 917 501 6744 SEEKING A ONE BEDROOM APARTMENT CAN YOU PLEASE SEND ME AN APPLICATION THANK YOU
Applied back in 11/17/2020 how can l find out what’s my status
Hi I would like an application please for a one bedroom
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While the rest of us are struggling to manage the complicated present situation, a maestro of flamenco dance, 85 well-kept years of age, with the aesthetic of Federico García Lorca engraved in each molecule of his being, follows his path with conviction and dignity.
seeing the typical brimmed hat and polkadot scarves
would disdainfully cross him off as a “tablao dancer”. But Antonio Santaella goes way beyond that. True enough
but his elegant personality has always kept him a class act. He has presented his personal vision of flamenco and Spanish dance in numerous theaters and other formal settings
with his admiration for Lorca always shining through. In addition to flamenco
he commands knowledge of regional Spanish and semi classical dances
director and creator for a long list of danced narrative works
dedication and a profound love of his culture are the characteristics that best define the artistic and human qualities of Antonio Santaella
I was born in a town on the Granada plain called Valderrubio
where García Lorca’s father had the most fertile land of the whole area. Lorca would spend his summers there
which became a source of inspiration for much of his work. I lived with my mother and siblings
and my love of flamenco didn’t come from the family
I picked it up from gypsy families in the neighborhood
who was in France from the end of the civil war
like so many other Spaniards fleeing from those horrible times
to live with him in France. That’s where I learned my first flamenco moves. Since I loved flamenco singing and dance ever since I was small
it was easier for me to get the aesthetic than for others not born in Spain
sheer desperation. That changed when I made friends in a gypsy family who were friends of my father’s
and who had arrived in France under similar circumstances. One of the boys played a little guitar
and that was all I needed to feel close to my roots. We invented dance steps and I tried to imitate Pepe Pinto
it was so joyful! One day we took a train to Paris
we heard the sound of castanets. They told us is was the maestro Rayito giving dance and guitar classes…at that moment the heavens seemed to open! And that’s how my career as a flamenco dancer got under way
There was a lot of work in Paris at the time. At La Guitare I crossed paths with Los Gitanillos de Cádiz
with the Príncipe Gitano and at the Olympia with Rafael Aguilar
Your work is strongly inspired in Lorca. What does Federico represent for you
Lorca is my inspiration and motivation to create. You can’t hear flamenco without thinking of him. You can feel his presence in everything I do! Remember I was born in the town where he spent a large part of his creative life
I worked at a tablao in Paris where the dancer Laura Toledo saw me and signed me up to tour the United States for two and a half years. I ended up in New York where I made my own group and worked at the elegant Chateau Madrid
in addition to a wonderful opportunity to do Carnegie Hall. It was a fabulous experience
I went to Puerto Rico with a contract for the Hotel El Convento where we stayed a long time. In the beginning people asked me for classes
a half-century later. Puerto Ricans really feel flamenco
and they express it very well! Many of my students have become professional
when the University of Puerto Rico was holding a Symposium of Poetry and Literature of the Americas
they commissioned me to do a choreography for the closing day. It went so well I said to myself this is for me! After that
my dream was to create works with cultural significance. And there were many
including a work for youngsters from ten to seventeen in which I explore all the problems that come with leaving school at a vulnerable age.
I took time out to go to Spain and enjoy my country
and I took classes with Antonio Marín as I had in earlier years. Since it was a long stay
I made a group and we were hired by Pasapoga on Madrid’s Gran Vía. I took Carmen Linares to sing
she was 16 years old and just debuting as a flamenco singer. The show was called Antonio Santaella y su Suite Flamenca. From there
I returned to New York to the Chateau Madrid. We were Nati Mistral y Antonio Santaella y sus Flamencos
and inserted flamenco culture in Puerto Rico thanks to your knowledge
and high-quality shows. Is your contribution valued in Puerto Rico? Have you received financial support
I’ve been helped by the Culture Institute and Endowment for the Performing Arts. Yes
I feel my work is appreciated here! I received recognition from the Senate
the medal of the Puerto Rican branch of the UNESCO
first prize from the Worldwide Dance Competition and many honorific plaques
Do you follow the evolution of flamenco dance in Spain? What do you think about the work of avant-garde dancers such as Israel Galván
you have to be creative. Without evolution you wouldn’t be able to express and explore the surrealism of a given topic. As far as Israel
and at times I manage to do so. When it comes to flamenco singing
and feeling my insides churn when I hear a siguiriya of Tomás Pavón
Mairena. That isn’t as likely to happen with evolutionary singers. Although I also accept and admire the evolution of the cante
but it mustn’t become detached from the essence
because then it would turn into something else
In what way have you been affected by the pandemic
in Puerto Rico we’re suffering with the terrible virus that extends more and more every day
possibly due to the flow of visitors from the United States
and the non-observance of protocol imposed by the government
adhering to the law of 30 percent capacity. In the meantime
Sus artículos han sido publicados en numerosas revistas especializadas y es conferenciante bilingüe en Europa
and website in this browser for the next time I comment
Δdocument.getElementById( "ak_js_1" ).setAttribute( "value"
Knowledge and passion The depth and the grief
EXPOFLAMENCO connects Flamenco communities around the world
Expectations still were relatively high for the Arlington baseball team
despite the graduation of several standouts
That belief was held in large part because of its pitching staff
which includes a trio of battle-tested standouts who know the pressure of a run to the section final
The first month of the season has been somewhat of a disappointment for the Admirals
has struggled as some newcomers sought to find their footing and some of the returners "pressed" while trying to compensate
Even those pitchers haven't been as sharp as their reputations would suggest
we'll be dangerous in the last third of the season."
Eric Servellon pitched a two-hitter with seven strikeouts
leading Arlington in a 7-0 road win over Carmel High School on Wednesday
Taking off: Maiale shines as new-look New Paltz baseball continues to ascend
Nine Who Shine: Arlington's Servellon among area's best returning baseball players
The West Virginia-bound senior effectively used his fastball and changeup in silencing the Rams
This followed a strong performance last week
when he earned the win against rival John Jay-East Fishkill
"He had his good stuff and managed it well," Biasotti said of the right-hander
who threw 66 of his 103 pitches for strikes
It's encouraging heading into the back part of the season."
As is the offense showing signs of awakening as the Admirals have won three of their last four
and Eric Santaella was 2 for 4 with two RBI and a run for Arlington (8-7)
"Eric has been our most consistent hitter so far," the coach said
"Joe popped up an off-speed pitch in his first at-bat
Sophomores Griffin White and Tim McCormack were promoted from junior varsity before this game with a hope of them helping to ignite the offense
The move paid off as White notched his first varsity hit
an RBI single that put Arlington on the board in the second
The Admirals pushed across at least a run in five innings
including two each in the fifth and sixth to secure the win
Nick Huchro and Jake Manco each had an RBI
Servellon walked four but allowed only singles to Nevin Scaperotti and Noah Jettleson
"We're hanging our hat on the fact we have three senior pitchers who've been in big games and can lead us," Biasotti said
"They're rounding into form and their experience will be a benefit in sectionals
Stephen Haynes: shaynes@poughkeepsiejournal.com
Home / News / Uncategorized /
[arve url=”https://vimeo.com/234898833″ width=”640″ height=”360″ frameborder=”0″ allowfullscreen=”allowfullscreen”]
hemophilia nurse coordinator in the Department of Pediatrics at the University of Miami Miller School of Medicine
has received the Nurse of the Year Award from the National Hemophilia Foundation (NHF)
The award was presented during the foundation’s recent annual meeting in Chicago
The award honors a nurse who has demonstrated service to the bleeding disorders community beyond day-to-day responsibilities
It is given to an individual who serves as a role model for others in the field and has a minimum of two years’ experience working in the bleeding disorders community
who were notified in advance that I was the winner,” said Santaella
who has worked at the Miller School for 15 years
and even though I was a co-chair of the annual meeting
I didn’t find out until it was announced at the nurses’ luncheon
I was very honored to receive the award because I’ve been working in this field a long time
and there are wonderful nursing professionals in it
My colleagues are incredible professionals who deserve it as much as I do.”
“This award is testimony to Maria’s devotion to
the bleeding disorders community,” said Joanna A
medical director of the Comprehensive Pediatric Hemophilia Treatment Center
“Those of us who work with her every day can attest to all the qualities which are recognized by this award
We at UM are very fortunate to have her as an integral part of our Hemophilia Treatment Center.”
who has been the pediatric bleeding disorders nurse coordinator at the Hemophilia Treatment Center since 2003
also was the adult nurse coordinator from 2007 to 2014
She is a published author in several scientific journals
co-developed the nationally recognized workshops Infusion 101 and Lighten Up
chairs the NHF’s Nursing Working Group and Sylvester Comprehensive Cancer Center’s Nursing Research and Evidence Based Practice
and is a member of several national interdisciplinary committees
Braulio Hernandez is five years cancer-free and speaking out about the need for increased funding for childhood cancer research
Clinicians can get the latest information on neuroendocrine tumor sat an upcoming Sylvester Comprehensive Cancer Center conference
chair of the DeWitt Daughtry Family Department of Surgery at the […]
Copyright © 2025 University of Miami Health System
2023TAMPA — Historic preservationists were furious in 2019 when the owners of West Tampa’s Santaella Cigar Factory chose to cover the exterior’s yellow bricks with white paint
City Council weighed in, too, discussing whether they should step in and force local historic landmark designation on the building
which would prevent the exterior from being modernized
The concern was that the paint job would ruin the historic integrity of the cigar factory built in 1904
deciding that the designation was up to the property owner
Most of the interior and less than half the Santaella’s exterior were painted white
and one of their first orders of business is to remove the white paint
It turns out that the paint could do more than ruin the cigar factory’s historic integrity: It could damage the structure
“It actually kills the brick,” said Andrew Coogan
recently began leasing the cigar factory so that they could begin restoration while finalizing the deal to purchase it
The cigar factory is not in imminent danger
but the paint could prevent it from surviving another 119 years
The exterior of the Santaella Cigar Factory Building in Tampa
[ JEFFEREE WOO | Times ]The couple plans to add a distillery
restaurant and wedding and event venue to the first floor
a garden courtyard outside and a rooftop bar that has a view of downtown
They also want to change the address from 1906 N
to reflect the year the cigar factory opened
The second and third floors will be refurbished but remain artist lofts
The current owners, Philip Farley III and Henry Bentley, had similar plans when they purchased the three-story
58,000-square-foot cigar factory for $3.2 million in 2018
Coogan has experience in renovation through his Coogan Window & Door installation company
and Ryann has been renting space in the factory for a few years for her photography
“I’d walk through and imagine what it could be like,” Ryann said
Future owners Andrew Coogan and Allie Ryann give a tour of the Santaella Cigar Factory in Tampa
[ JEFFEREE WOO | Times ]Another tenant told her the building was for sale
“It was pretty organic the way the opportunity came up,” Ryann said
We then kind of just started tinkering around with ideas and kept going
We both agreed that cigar factories are worth investing in.”
Coogan and Ryann might seek the designation. But they first want to focus on finalizing the sale, signing first-floor tenants and, of course, removing that white paint.
“It’s an ambitious goal,” Coogan said. “The building has great possibility and is worth the work. We didn’t want to be those people who are not willing to pick up the sword.”
Paul Guzzo is a former culture reporter.
Volume 9 - 2017 | https://doi.org/10.3389/fnagi.2017.00201
a mind-body activity that requires attentional engagement
has been associated with positive changes in brain structure and function
has also been associated with structural and functional brain changes
but these generally involve decreased cognitive functions
The aim of this cross-sectional study was to compare brain cortical thickness (CT) in elderly yoga practitioners and a group of age-matched healthy non-practitioners
We tested 21 older women who had practiced hatha yoga for at least 8 years and 21 women naive to yoga
meditation or any mind-body interventions who were matched to the first group in age
years of formal education and physical activity level
A T1-weighted MPRAGE sequence was acquired for each participant
Yoga practitioners showed significantly greater CT in a left prefrontal lobe cluster
which included portions of the lateral middle frontal gyrus
anterior superior frontal gyrus and dorsal superior frontal gyrus
We found greater CT in the left prefrontal cortex of healthy elderly women who trained yoga for a minimum of 8 years compared with women in the control group
Yoga involves the practice of postures, breathing exercises and meditation. While branches of yoga adopted in the West have a strong physical component (postures and breathing exercises), yoga is not limited to the physical body. By definition, yoga is a meditative activity embodied in physical postures in which an attentional component must be present (Taimni, 1961)
yoga is considered a contemplative practice
many performed volumetric and region of interest (ROI) analyses and showed mostly mixed results
with different brain regions reported in different studies
There are even fewer studies related to the practice of yoga and morphometric differences in aging
it is important to investigate the effects of yoga in an increasingly older population
the aim of this study was to compare brain cortical thickness (CT) in elderly female yoga practitioners and healthy non-practitioners
Twenty-one female hatha yoga practitioners who practiced at least twice a week for a minimum of 8 years
were recruited from hatha yoga studios in São Paulo
one of the most common yoga branches in the West
pranayama (breathing exercise) and dhyana (meditation)
We also recruited an additional group of 21 women who were naive to yoga
meditation or any mind-body intervention and were matched to the first group in age
years of formal education and level of physical activity
Subjects were matched for physical activity based on the practices of the Yoga group—those who did not practice any activity other than yoga were matched to sedentary controls and those who practiced yoga plus another physical activity were matched to a control group member who practiced the same or equivalent physical activity
Inclusion criteria were: at least 60 years of age
right-handed and having completed at least elementary school
We chose to include only women to add an element of homogeneity to the group
it was also easier to identify female yoga practitioners than male practitioners
Exclusion criteria were: substance abuse; tremor or dystonia of the head; chronic physical or other health problems that prevented them from performing their daily activities independently; any contraindication to MRI; a clinical history of neurological and/or psychiatric diseases
All volunteers provided written informed consent and the study was approved by the Institutional Review Board of Hospital Israelita Albert Einstein (CAAE 22313813.7.0000.0071)
Instrumental Activities of Daily Living—IADL: scores range from 9 (low function) to 27 (high function). Items are evaluated regarding individuals’ ability to perform each task (independently, with others’ help, or not at all; Lawton and Brody, 1969; Santos and Virtuoso, 2008)
Beck Depression Inventory—BDI: self-report questionnaire with 21 multiple choice questions addressing several depression symptoms. Scores range from 0 to 63 (Beck, 1978; Gorenstein et al., 1999)
Mini Mental State Examination—MMSE: test that evaluates several domains of cognitive function, such as spatial and temporal orientation; calculation; immediate and evoked memory; language-naming; writing; repetition and copying a drawing. Scores range from 0 to 30 (Folstein et al., 1975)
Anthropometric measurements—Weight and height were measured
A T1-weighted MPRAGE sequence was acquired for each participant using a Siemens 3.0T Magnetom Tim Trio System with a 12-channel head receive coil (matrix 1 × 1 × 1 mm voxel
Image quality was visually inspected immediately after each structural acquisition to control for motion effects and other artifacts
The FreeSurfer analysis suite (v5.3.0 release) was used to derive models of cortical surface in each T1-weighted image. These validated and fully automated procedures have been extensively described elsewhere (e.g., Dale et al., 1999; Fischl and Dale, 2000)
a single filled white matter volume was generated for each hemisphere after intensity normalization
and image segmentation using a connected components algorithm
a surface tessellation was generated for each white matter volume by fitting a deformable template
This resulted in a triangular cortical mesh for gray and white matter surfaces consisting of approximately 150,000 vertices (i.e.
Measures of CT were computed as the closest distance from the GM and white matter boundary to the GM and cerebrospinal fluid boundary at each vertex on the tesselated surface
Mean CT across the entire brain was also computed for each participant
Thickness data were smoothed using a 15-mm surface-based smoothing kernel
Group differences in mean CT were assessed by an independent samples t-test
Data obtained from questionnaires and anthropometric measurements were analyzed using the SPSS 17.0 program (SPSS Inc.
Variables were compared using Student’s t or Mann Whitney tests
The yoga group had 14.9 years of hatha yoga practice, on average. There were no significant differences between groups in terms of age, years of education, questionnaire scores or anthropometrical measures, as shown in Table 1
Relative to controls, yoga practitioners (i.e., female yoga practitioners) showed a significantly greater CT in a left prefrontal lobe cluster (cluster forming threshold p < 0.05, cluster corrected p-value = 0.01574), which included anterior and lateral portions of middle and superior frontal gyri (BA8/9; Figure 1, Table 2)
No regions exhibited decreased CT in yoginis compared to controls
The age by group interaction was also not significant
There were no significant between-group differences in mean CT for the whole cortex
as assessed for each hemisphere individually (t(40) = −0.690
Differences in cortical thickness (CT) between yoginis and controls (P < 0.05
Yoga practitioners showed greater CT in a cluster in the left prefrontal cortex (RTF-based
Anatomical and statistical information of the cluster in which significant between-group differences in cortical thickness (CT; i.e.
yoga practitioners > Controls) were detected
it is unlikely that the differences observed between groups are due to demographic characteristics or depressive symptoms
we observed alterations in areas associated with executive functions of attentional control rather than motor regions
Even though the studies mentioned above detected cognitive alterations
individuals across groups should have performed the same physical activities (other than yoga)
Matching participants on this variable proved to be very difficult
we matched as best we could based on relative physical effort
as the number of participants in each group was relatively small
it did not allow us to make comparisons between individuals from different ethnic groups
our volunteers performed only one MRI scan
Future studies should involve longitudinal randomized controlled trials and correlations with other peripheral measures
healthy elderly women who practiced hatha yoga for at least 8 years had greater prefrontal CT than a group of matched controls
This CT may be associated with cognitive preservation
RFA: acquisition of data; design; interpretation; revising and final approval of the article; agreement to be accountable for all aspects of the work
JBB and JRS: analysis; revising and final approval of the article; agreement to be accountable for all aspects of the work
SL and SSL: interpretation; revising and final approval of the article; agreement to be accountable for all aspects of the work
NI: acquisition of data; final approval of the article; agreement to be accountable for all aspects of the work
DFS: interpretation; final approval of the article; agreement to be accountable for all aspects of the work
EA: revising and final approval of the article; agreement to be accountable for all aspects of the work
EHK: conception and design of the work; analysis and interpretation of data; revising and final approval of the article; agreement to be accountable for all aspects of the work
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; 2015/18262-7)
Instituto Israelita de Ensino e Pesquisa Albert Einstein and Instituto de Ensino e Pesquisa em Yoga (IEPY)
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
We would like to thank Telma Busch and Michel Naslavsky for their technical support
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and Kozasa EH (2017) Greater Cortical Thickness in Elderly Female Yoga Practitioners—A Cross-Sectional Study
Received: 12 September 2016; Accepted: 06 June 2017; Published: 20 June 2017
Copyright © 2017 Afonso, Balardin, Lazar, Sato, Igarashi, Santaella, Lacerda, Amaro and Kozasa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
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Taylor Martinez Santaella and his mother Irma Martinez are taking over the downtown pie shop
Haz clic aquí para leer versión en español.
have an announcement to make that’s as sweet as their Banana Cream Pie
But it also has a bittersweet streak to it
like their Apple Pecan Crumble with Salted Caramel
said they are “passing the rolling pin” to new owners: Petaluma Pie Company employee Taylor Martinez Santaella and his mother and new co-owner
arrived at Petaluma Pie Company about two years ago
having previously worked at Red Bird Bakery and Acre Pizza
He’s been a baker and pie-lover “since he was young,” said his mother
and Martinez Santaella called their new endeavor “a dream come true.”
Hoshino and Sacerdote said they opened their pie shop in 2010 “with a shoestring budget from personal savings and modest investments from friends and family.” Given such limited means
the loss of their custom business sign to thieves before they even opened seemed devastating – “But at the same time
we got unexpected publicity,” said Hoshino
“We had people lining up at the door on our first day.”
petalumapiecompany.com
enamored by the sweet and savory pies which so often take the form of “hand pies” – like the meaty little wonder called the Cheeseburger Pie ($9.75) which is made
“with grass-fed beef from Stemple Creek Ranch and organic cheddar cheese.”
After buying a Cheeseburger Pie (or Mushroom and Goat Gouda Pie
customers can stroll over to one of Putnam Plaza’s many tables
Besides baking great pies people want to line up for
Hoshino and Sacerdote made their cozy little shop on the plaza an appealing place to be
holding “Pie-Ku Contests on Pi-day,” concocting new pies for special occasions such as weddings
“A Deaf staff member initiated Deaf Pie Happy Hour
and offering a 15% discount to people who placed their order using American Sign Language,” they said
it will be Martinez Santaella “rolling out the dough and adding his own ideas to the pie shop repertoire.”
All four of them – the two former owners and the two new ones – agree that keeping the shop local
with owners who care about the food and the community
Volume 11 - 2019 | https://doi.org/10.3389/fnagi.2019.00158
Large-scale brain networks exhibit changes in functional connectivity during the aging process
Recent literature data suggests that Yoga and other contemplative practices may revert
some of the aging effects in brain functional connectivity
The aim of this cross-sectional investigation was to compare resting-state functional connectivity of the medial prefrontal cortex (MPFC) and posterior cingulate cortex—precuneus (PCC-Precuneus) in long-term elderly Yoga practitioners and healthy paired Yoga-naïve controls
Hatha Yoga practitioners; practicing a minimum of twice a week with a frequency of at least 8 years) and a control group (C-20 women
and physical activity) were evaluated for: Mini Mental State Examination (MMSE)
Instrumental Activities of Daily Living (IADL)
and open-eyes resting-state functional magnetic resonance imaging (fMRI)—seed to voxel connectivity analysis (CONN toolbox 17.f) with pre-processing—realignment and unwarping
The analysis included a priori regions of interest (ROI) of DMN main nodes—MPFC and PCC-Precuneus
There was no difference between groups in terms of: age
The Yoga group had a higher correlation between MPFC and the right angular gyrus (AGr)
Elderly women with at least 8 years of yoga practice presented greater intra-network anteroposterior brain functional connectivity of the DMN
This finding may contribute to the understanding of the influences of practicing Yoga for a healthier cognitive aging process
reflecting the need for research efforts to find effective low-cost and low side-effect methods to counteract them
we aimed at investigating MPFC and PCC-Precuneus as the two seed-based regions of interest (ROIs) for functional connectivity analysis
We hypothesize that long-term elderly Yoga practitioners with at least 8 years of regular practice have increased anteroposterior resting-state functional connectivity compared to paired Yoga naïve
In order to ensure a better psychological matching between groups
Beck Depression Inventory (BDI) was also applied
This test evaluates cognitive function in domains such as spatial-temporal orientation; language-naming; calculation; writing; repetition and copying; immediate and evoked memory. Its application results in scores which range from 0 to 30 (Folstein et al., 1975)
Self-reported questionnaire, which has 21 multiple choice questions (scored from 0 to 3) to address depression symptoms. Total scores range from 0 to 63 (Beck, 1978; Gorenstein et al., 1999)
The ability of the participant in performing each task (independently; with the help of others or not at all) is scaled and presented as results in a score at each item evaluated. Scores close to 9 are considered as indicative of a low function, while a high function is given by scores closer to 27 (Lawton and Brody, 1969; Santos and Virtuoso, 2008)
Weight and height were measured as anthropometric variables
MRI data were collected on a 3.0T MR system (Siemens Tim Trio
Subjects were instructed to avoid head movements and to keep their eyes open staring at a fixation cross presented at the center of the visual field
Functional images were acquired in a 7 min scan using a blood oxygen level-dependent (BOLD) sensitive gradient echo-planar-image (GRE-EPI) pulse sequence with the following parameters: 2D oblique axial plane (AC-PC oriented); 33 slices with 2.4 mm thickness and 0.4 mm gap
in-plane resolution = 3.4 mm × 3.4 mm and flip angle = 90°
High spatial resolution anatomical images were acquired using a T1-weighted MPRAGE sequence with the following parameters: 3D sagittal plane acquisition
TR: 2,500 ms; TE: 3.45 ms; 1 mm isotropic voxels; Flip angle: 7°; acquisition matrix: 256 × 256; NEX: 1
DMN main nodes (MPFC and posterior cingulate gyrus—PCC-Precuneus) were a priori ROI used as seeds in the resting-state functional connectivity analysis (Figure 1). Seeds were selected from prior studies (Whitfield-Gabrieli and Ford, 2012), and defined with masks from the Harvard-Oxford Atlas
Medial prefrontal cortex (MPFC—MNI coordinates: +1 + 55 −3) and posterior cingulate cortex-precuneus (PCC-precuneus—MNI coordinates: +1 −61 + 38) used as regions of interest (ROIs) for respectively anterior and posterior components of the default mode network (DMN)
Connectivity first-level correlation maps were produced by extracting the mean BOLD time course from voxels within each seed and computing Pearson’s correlation coefficients between that time course and the time course of all other voxels
Correlation coefficients were converted to normally distributed Z-scores using the Fisher transformation in order to allow second-level General Linear Model analysis
Two sample t-tests were performed on the Fisher transformed r-maps to examine differences in resting-state functional connectivity between the Yoga and Control groups
Group-level effects were considered significant if they exceeded a peak amplitude of t > 3.09
and a family wise error corrected cluster extent threshold of p < 0.05
Sample characteristics of the volunteers in the Yoga and Control groups are shown in Table 1—no difference was found between the groups: all volunteers were over 60 years old; with their body mass index (BMI) inside normality range and average years of formal education above the Brazilian average (7.8 years); Mini Mental scores did not indicate any cognitive impairment; BDI scores ranked at minimum
and IADL results were also within normality
Sociodemographic characteristics of the volunteers in the Yoga and Control groups
A graphic representation of DMN ROIs used as seeds for the connectivity analysis is presented in Figure 1
When MPFC was used as ROI for functional connectivity analysis, with the contrast Yoga > Control, the Yoga group presented a significantly increased correlation between MPFC and the right angular gyrus (AGr), compared to the Control group. Specific data is as follows: peak-cluster coordinates: +64 −50 + 26; cluster size: 127; cluster p-value FWE: 0.042347 (Figures 2, 3)
When the contrast Control > Yoga was used
no significant difference was found between the two groups
Graphic representation of the resting state functional connectivity of the DMN during resting-state
Women in the Yoga group had significantly greater correlation (p < 0.05) between the MPFC and right angular gyrus (AGr) than the Control group
Resting state functional connectivity of the DMN during rest
Women in the Yoga group had significantly greater correlation (p < 0.05) between the MPFC and right angular gyrus than the Control group
There was no significant difference between the two groups when PCC-Precuneus was used as ROI for functional connectivity analysis neither using the contrast Yoga > Control nor Control > Yoga
we found greater resting-state anteroposterior functional brain connectivity between the MPFC and the angular gyrus (AGr) in healthy elderly women who practiced Yoga for at least 8 years
when compared to the paired Yoga-naïve controls
Those findings motivated us to address the possibility of a resting-state functional connectivity difference between Yoga practitioners and controls
which found greater functional connectivity between the anterior cingulate cortex and bilateral anterior insula/putamen during a meditation-state
the increased resting-state connectivity between anteroposterior areas of the DMN in long-term healthy elderly Yoga practitioners has not been demonstrated in the literature to date
and may form one of the important contributions of this work to the scope of resting-state functional connectivity influences of Yoga practice in the elderly
Such findings are consistent with the hypothesis that training focused attention on comfortable sensations perceived during stretching and body-related respiratory movements during the permanence in postures of Hatha Yoga
named asanas may entrain brain pathways and/or systems which otherwise would gradually become less and less active along the aging process
helping to preserve brain connectivity and self-consciousness
contributing to being healthier during old-age
elderly women with at least 8 years of yoga practice present greater intra-network anteroposterior brain resting-state functional connectivity of the DMN
This finding may contribute to a better understanding of the influences of Yoga practice for a healthier cognitive aging process
The raw data supporting the conclusions of this manuscript will be made available by the authors
The study protocol was approved by the Institutional Review Board of Hospital Israelita Albert Einstein (CAAE 64633317.7.0000.0071)
revising and final approval of the article and agreement to be accountable for all aspects of the work
SSL and SL: revising and final approval of the article and agreement to be accountable for all aspects of the work
This work was supported by the Instituto Israelita de Ensino e Pesquisa Albert Einstein and Instituto de Ensino e Pesquisa em Yoga (IEPY)
We would like to thank Bruna Portes and Liana Guerra Sanches-Rocha for their technical support in brain image acquisition and analysis and Karina Fernandes Correa and Alda Fernandes de Castro for their operational support in handling the schedule and volunteer recruitment
The neural mechanisms of meditative practices: novel approaches for healthy aging
Greater cortical thickness in elderly female yoga practitioners-a cross-sectional study
Meditation experience is associated with differences in default mode network activity and connectivity
Reduced resting-state brain activity in the “default network” in normal aging
Session II: mechanisms of age-related cognitive change and targets for intervention: neural circuits
“Mini-mental state:” A practical method for grading the cognitive state of patients for the clinician
Potential self-regulatory mechanisms of yoga for psychological health
Fluid intelligence and brain functional organization in aging yoga and meditation practitioners
Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and Vipassana meditation than in controls
Psychometric properties of the portuguese version of the beck depression inventory on Brazilian college students
doi: 10.1002/(sici)1097-4679(199905)55:5<553::aid-jclp3>3.3.co;2-4
Differences in brain structure and function among yoga practitioners and controls
Imaging the default mode network in aging and dementia
The nuisance of nuisance regression: spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity
Abnormal salience network in normal aging and in amnesic mild cognitive impairment and Alzheimer’s disease
Hernández
Gray matter and functional connectivity in anterior cingulate cortex are associated with the state of mental silence during sahaja yoga meditation
Hernández
Network-specific effects of age and in-scanner subject motion: a resting-state fMRI study of 238 healthy adults
Mini Mental State Examination (MMSE)—probably one of the most cited papers in health science
Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging
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Wheaton: The Theosophical Publishing House
Characteristics of the default mode functional connectivity in normal ageing and Alzheimer’s disease using resting-state fMRI with a combined approach of entropy-based and graph theoretical measurements
The angular gyrus is a supramodal comparator area in action-outcome monitoring
Vidal-Piñeiro
Decreased default mode network connectivity correlates with age-associated structural and cognitive changes
Whitfield-Gabrieli
Default mode network activity and connectivity in psychopathology
doi: 10.1146/annurev-clinpsy-032511-143049
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Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks
WHO. (2014). Aging. Available online at: http://www.who.int/topics/ageing/en/
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Lazar S and Kozasa EH (2019) Greater Anteroposterior Default Mode Network Functional Connectivity in Long-Term Elderly Yoga Practitioners
Received: 26 February 2019; Accepted: 12 June 2019; Published: 02 July 2019
Copyright © 2019 Santaella, Balardin, Afonso, Giorjiani, Sato, Silva Lacerda, Amaro, Lazar and Kozasa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited
*Correspondence: Danilo Forghieri Santaella, ZGFueW9nYUBnbWFpbC5jb20=
.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Patrick Johnson | Special to The Republican427 smack.jpg
and cash seized in the arrest of two suspected drug dealers on April 26,2017 on Coomes Street
SPRINGFIELD - Police arrested two suspected heroin dealers and seized two handguns and more than 400 packets of heroin Thursday night as part of an investigation into drug sales from a Forest Park residence
Narcotics detectives arrested Rafael Santaella
after stopping their car in the area of Bridge and East Columbus streets
Santaella spotted them and attempted to flee
and Santaella put his car into reverse and drove into a police car
Christopher Hitas smashed the driver's side window in order to reach in and turn off the car's ignition
police obtained a district court warrant to search Santaella's residence on Coombs Street
The arrests came after undercover officers witnessed two drug transactions in different parts of the city
Officers tailed the customers from each location and arrested them
detectives followed the car back to the Coomes Street residence
where Santaella would go inside for a few moments before returning to the car
stamped with a logo reading "White House."
They also found two unlawful guns and ammunition
Santaella was charged with distribution of heroin
two counts of possession of a firearm without a license
possession of ammunition without a firearms identification card
Mondon was charged with distribution of heroin
Each is scheduled to be arraigned Thursday in Springfield District Court
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MAHOPAC - As the sun set on the final day of the regular season
Arlington broke its post-game huddle and it with one thing in mind − and it wasn't celebrating the 14-6 win over league foe Mahopac
"They know the deal," Arlington coach John Biasotti said
"They know we gotta come out and fix the things we've been doing wrong
It's been the same things we're doing wrong all season
but we're getting better and we've got a couple days to practice and get ready for Monday
Scoreboard: Scores, results and more for May 8-10 high school baseball games
Dom Cecere Way: Eastchester honors legendary coach with street renaming ceremony
Milestone win: Byram Hills coach Scott Saunders reaches 200-win milestone in final season
While both Mahopac and Arlington were resting their arms for the postseason and throwing in multiple pitchers to spread the workload
it was an offensive display at the plate for both teams
but Mahopac stayed close behind through the first four innings
Arlington held a 6-5 lead going into the top of the fifth
when the Admirals broke the game open by scoring four runs in both the fifth and sixth innings
we're ready for the playoffs," Arlington junior Eric Santaella said
Arlington finishes the regular season 10-10
but there was nothing middle-of-the-pack about its grueling schedule
Between a tough league that features Ketcham
the Admirals also underwent a challenging non-league slate to complement their league gauntlet
The hope is to prepare them for the postseason
"Guys came up and had big hits in big spots
so it's good to see that because that's something we had been struggling with this year," Biasotti said
"Just consistency offensively and hitting with runners in scoring position
so it's good to see we could do that today
We go into the season and try to schedule the toughest opponents possible knowing that we won't win them all but it will prepare us for this time of year
we're probably better than that because we've been in every single game
but at the end of the day that's where we're at so our seed is what it is
but I think we're battle-tested and ready."
Mahopac is another team hoping to make a run
but couldn't muster the timely hits like Arlington did
Indians first-year coach Anthony Nappi had experience with putting together a run last season
when he guided Somers to a sectional championship win that turned plenty of heads
"I really was more disappointed in the defense
and we have to play good defense to win games
Can't give good teams extra outs like that
We're capable of beating good teams and playing good clean baseball
we pitch like we'd been pitching recently and get the defensive side of it
what we're capable of and make sure that spills into the postseason."
and the final time these two will face each other
as Arlington prepares for the Class AA playoffs
Arlington: He went 3-for-4 with a double and a game-high five RBI
like his first to put the Admirals on the board
and his next two in the top of the fifth to spark the scoring run
By the numbersArlington (10-10) − Eric Santaella went 5-for-5 with three RBI and four runs scored
Griffin White was 2-for-3 with three RBI and a run
Christian Adorno went 3-for-4 with a RBI and a run
Mahopac (9-9-2) − Tyler Castrataro went 3-for-3 with a double
Drew Lichtenberger had a double and one RBI
They said it"We're all dogs," Santaella said of what makes his team dangerous
"None of us is scared of any pitcher or any hitter
we're just up there to play ball and have fun with it."
I try to not talk about it too much because I want us to have our own identity
but I do feel there's a lot of similarities in our group as far as how the season went with a bit of ups and downs," Nappi said when looking at his Somers team last year and his Mahopac team this year
we had a lot of big innings that we let up with a couple of errors and all of a sudden we gave up 5-6 runs on the board
and we stop the bleeding and don't let a big inning come into play because of a couple mistakes we can go on a run
but we need to play clean and that's what it comes down to
Follow Eugene Rapay on Twitter at @erapay5 and on Instagram at @byeugenerapay.
In turn, they have transformed that brick building into a bohemian jewel alongside a West Tampa road best known for speeding cars.
But last month, the three-story, 58,000-square-foot building at 1906 N Armenia Ave. was sold to new owners with big plans that have tenants both enthusiastic and worried about what the future holds for them.
Building improvements are needed, but the photographers, painters, sculptors, writers and other resident-artists now wonder how changes will affect the affordability and serenity they enjoy.
"This place is a hidden gem and any change is scary," said Gene May, a commercial producer and event coordinator who has rented studio space there since 2011. "The upgrades the new owners want to make work great for me so I'm excited, but will they work for everyone? And what will this mean for rent?"
Michael Hettrich, who with his business partner Philip Farley III purchased the cigar factory for $3.2 million, says his vision includes air conditioning for all, landscaping, a new elevator and bathrooms, improved interior and exterior lighting and a fix up of anything in need of repairs.
The artists "have fundraisers here every year and then they use the money to do things like replace lighting," said Hettrich said. "They won't have to do that anymore. If we do a fundraiser, it will benefit them."
The building will also have a new name - the Ampersand Cooperative.
While no Santaella artists would share what they pay for rent, they said the former owners, Ellis-Van Pelt Inc. — who declined to comment — founded the studios to support the arts and not turn a profit.
Hettrich estimates he could spend as much as $1 million on the building.
Will that plus the purchase cost mean rent goes up? Will the current month-to-month leasing that provides financial flexibility continue? All Hettrich would say for now is that the top two floors will remain art studios.
"I am going to polish this jewel," said Hettrich, whose St. Petersburg company Octillion design + build has the motto, "We build cool stuff" and whose past local clients include Kahwa Coffee. "I am going to make it look awesome."
The garden level basement and first floor where the ex-owners ran a furniture business will be merged and made into one multi-tier level for an event space, micro-brewery, cafe and marketplace that on weekend nights will expand to the parking lot and be available to resident artists and outside vendors.
That obviously expands sales opportunities for artists, said producer May, and he will make use of the events space. Still, he wonders about those who need quiet and solitude to work.
"This all sounds amazing," said Kerry Vosler, who since 2009 has rented at Santaella to paint portraits and teach art. "I just hope they are able to maintain studios that are workable for the artists."
And despite their ambitious plans, both new owners have battled legal problems on past ventures.
In February, Farley pleaded guilty to negligently causing the release of asbestos when he developed St. Petersburg's Urban Style Flats apartments.
In 2015, according to court records, Hettrich's Artisan Group in Cook County, Illinois was ordered to pay a client nearly $424,000 in damages for fraudulent construction services. And in October in Pinellas County, Hettrich was charged with one felony and six misdemeanors stemming from contracting without a license.
At least one tenant says the changes won't work for her. So, she is leaving.
"I was already thinking about working from home," said painter Stephanie Ong who rented at Santaella for five years. "This made the decision easier. It sounds like a lot of construction and I don't want to deal with that. I wish the new owners well. They sound great."
Times senior news researcher Caryn Baird contributed to this report. Contact Paul Guzzo at pguzzo@tampabay.com. Follow @PGuzzoTimes.
Paul GuzzoFormer Culture and Hillsborough Reporter
Santaella said she took a picture of three women in costumes shortly after 10 p.m.
and she then went down an alleyway to make her way home
and she started to feel squeezed by the crowd
my feet weren't even touching the ground anymore," she told the Post
"There was an unconscious guy on top of me
Santaella recalled being crushed to the point where the only body part she was able to move freely was her neck as she became stuck with people and below her
I'm going to be next.' I really thought I was going to die," she told The Post
She said she started to focus on taking shallow breaths through her mouth as her lungs began to feel like they were being flattened
People around her started calling out for help
Santaella told the Post that she was saved by a young man standing on an elevated ledge who grabbed her arms and pulled her up with him
She said she eventually made it home safely
But the 23-year-old said she developed a fever overnight and brought herself to the emergency room of a nearby hospital on Sunday
At least 154 people are known to have died following the tragic incident, which has left the country in shock, the BBC reported.
Police said they've launched a 475-member task force to investigate the crush
GREEN BAY - Two men from Venezuela will spend considerable time in Brown County Jail for using a "card-skimmer" at a local gas station to steal credit card information from unsuspecting people
were sentenced in Brown County Circuit Court this week in a 2016 card-skimming case.
Romero-Santaella received 11 months in jail and Chacin-Paredes was sentenced to 12 months
The men were charged last year with 10 counts each of attempted misappropriation of personal identifying information
Both men pleaded no contest to six of the counts
Each count carried a possible penalty of three years in prison
The two were taken into custody in November after a manager of a gas station on West Mason Street notified police he found card-skimmer equipment installed on one of his pumps
Officers ultimately caught Romero-Santaella and Chacin-Paredes trying to retrieve the equipment from the pump
The equipment included a ribbon-like card reader installed in the pump and a camera
hidden within a makeshift panel above the credit card keypad
It captures card numbers and PIN numbers from each transaction at the pump
Judge Timothy Hinkfuss sentenced the men to jail time instead of prison because neither man has ties to the area
would leave room for the possibility for them to flee to their home country
Police initially identified both men as being from Venezuela, but that Chacin-Paredes did have a green card and a Florida driver’s license listing a Miami address
Hinkfuss questioned why the men would come to Green Bay to commit their crimes.
said her client was desperate to provide money for his family after being laid off from his job
police searched a car the two had rented
found a hotel room key and obtained a search warrant
That search turned up a laptop computer which listed names and credit card numbers of people whose cards were skimmed
Police identified 10 people whose credit card information was stolen.
There is no evidence the information was sold or used to make purchases without cardholders' knowledge
Neither Romero-Santaella or Chacin-Paredes have a past criminal record
Hinkfuss agreed with prosecutor Dana Johnson that the men must face strict punishment to deter others from committing similar crimes.
"We need to show to the community that if you're going to do something like this
police learned of another gas station in Green Bay where skimming equipment had been installed.
TAMPA ― Historic preservationists have not been happy with Michael Hettrich’s work on West Tampa’s 116-year-old Santaella Cigar Factory
They claim his vision, which includes painting its yellow bricks white
would destroy the historic fabric of the building
might be out of the factory’s ownership group
Hettrich is taking his former partners to court and demanding they pay what he says he is owed
According to Hettrich’s civil lawsuit filed earlier this month with the Pinellas County Sixth Judicial Circuit, factory owners Phil Farley and Henry Bentley promised him a 20 percent “non-voting” interest in the Santaella, the Y. Pendas y Alvarez Cigar Factory also in West Tampa
he remained their employee providing “construction and property management services related to remodeling
refurbishing and restoration of the properties.” The deal also included 20 percent of the annual profits from those ventures
a 72-year-old resident of North Redington Beach
he “seeks a formal and accurate 2020 fiscal year-end accounting and payment of his 2020 (and future) compensation and distributions owed to him by the defendants.”
The Tampa Bay Times left two voicemails at a number associated with Farley and Bentley
Voicemail did not identify the number’s owner
In 2018, the ownership group purchased the Santaella at 1906 N. Armenia Ave. for $3.2 million. A year later, for $3.6 million, the group purchased the 112-year-old Pendas factory
The Santaella had previously been used as artist lofts
Hettrich promised to remodel the 58,000-square-foot building
allow the artists to remain and add a microbrewery and cafe
Plans for the 60,000-square-foot Pendas factory were never announced
The Santaella’s white paint job is incomplete
The Times did not see active construction at the site on Monday morning
but a tenant who would not identify himself declined to allow the Times inside or answer questions
A sign outside says the building is for lease via Retail Solutions Advisors
There is no sign outside the Pendas factory
but it is listed as for lease on Retail Solutions Advisor’s website
Both Hettrich and Farley have a history of code violations
In January 2019, the city ordered construction stopped on the Santaella project until they obtained proper permits.
Hettrich’s Artisan Group in Cook County, Illinois, was once ordered to pay a client nearly $424,000 over fraudulent construction services.
And Farley once pleaded guilty to negligently causing the release of asbestos in the development of St. Petersburg’s Urban Style Flats apartments.
Preservationists lauded the work Hettrich was doing to the Santaella’s interior but were angered in July 2019 when construction crews began painting the brick factory’s exterior white. They believe the building is historic and that its exterior should not be modernized.
To prevent something like that from happening again, Tampa City Council then discussed whether they should force local historic designation onto all cigar factories, a label that prevents modernizing exteriors. That has not happened.
Of the 200 or so factories that operated in Tampa’s heyday as cigar capital, the late 1800s through mid-1900s, only about two dozen remain. Half carry historic protection. Neither the Santaella nor Pendas factories are among those.
.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Adam Ferrise, cleveland.comIan Bobich
Ohio -- A Cleveland native was shot and killed Monday outside an apartment building in Anchorage
was found dead of a gunshot wound about 11 p.m
Monday in Anchorage's Government Hill neighborhood
Residents reported hearing gunfire and police found Bobich dead on the ground
Anchorage police said they have not made an arrest in the case and are unsure of a motive
Bobich was an apprentice in the Sheet Metal Workers 23 union in Anchorage
He said Bobich moved from Cleveland to Anchorage about 10 months ago to find better work opportunities
He landed a job with the union in Alaska and moved there with his longtime girlfriend
Santaella said Bobich turned his life around after serving a seven-year federal prison sentence for conspiring to sell cocaine
and an additional year for violating probation
Santaella said he and Bobich became especially close after Bobich was released from prison in December 2013
Both grew up on the West Side and that Bobich sense of humor was infectious
"He was a regular Cleveland kid," Santaella said
He tried to really turn his life around."
Santaella said Bobich recently told him he was moving back to Cleveland to take a similar job. He was in the process of selling things to make his move easier. Bobich's family is trying to get him back to Cleveland to buried and have set up an account on gofundme.com
"He was coming home," Santaella said
"He texted me to see if I could pick him up from the airport."
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Chef Erwin Husken hasn’t just created the signature eatery in Aruba — he’s developed what is the best restaurant in the Caribbean in 2015
chic restaurant where the food just keeps getting more creative
It’s the biggest thing in travel right now
But they don’t just want the unlimited food and beverage
The term “green” has never been more important
but it’s also never been a broader term
What once merely meant a degree of environmental focus
has now expanded to encompass everything from renewable energy to sustainability to community tourism
Belize has come out on top of the Caribbean as the region’s happiest country
Caribbean Journal has learned. The Caribbean country on the coast of Central America was ranked 25th overall in the world
Bookings for 2025 have “remained on track,” Royal Caribbean President and CEO Jason Liberty said in its recent earnings report
in a positive sign for the travel industry amid global uncertainty. The company cited record bookings during the key Wave […]
Overwater bungalows are relatively new to the Caribbean
both in islands like Jamaica and Antigua and their traditional stronghold in the Bocas del Toro archipelago on the Caribbean coast of […]
The first thing you fall in love with here is what isn’t here
You can hear the palm trees actually shake
You can find the Caribbean you’re […]