A new conservation initiative has taken root in the Judean Hills, where Keren Kayemeth LeIsrael – Jewish National Fund (KKL-JNF) has partnered with the Butterfly Enthusiasts Israeli Association to protect one of Israel’s rarest butterflies
The project centers on planting 60 seedlings of the large-fruited milk-vetch plant
crucial for the survival of the protected Tomares Nesimachus butterfly
among Israel’s 14 protected butterfly species
faces a precarious future due to its complete dependence on the large-fruited milk-vetch plant as a place to lay its eggs
While the plant typically thrives in northern Israel
The initiative sparked when members of the Butterfly Enthusiasts Israeli Association discovered the butterfly on a milk-vetch plant in KKL-JNF’s Begin Park
which covers approximately 2,000 acres in the heart of the Jerusalem Mountains
This finding catalyzed a coordinated conservation effort: KKL-JNF collected seeds from existing plants and transferred them to its Eshtaol Nursery in the Judean foothills
where 60 seedlings were successfully cultivated
These young plants have now been reintroduced to the Begin Forest through a collaborative planting effort involving community volunteers
“This initiative is a wonderful example of collaboration between communities
and professional organizations,” says Nurit Hibsher
head of the Forest Department at the KKL-JNF Central Region
“Preserving biodiversity and protecting rare butterflies like the Tomares Nesimachus is an integral part of our vision for safeguarding nature and the environment in the Judean Hills.”
head of the KKL-JNF Seed and Nursery Department
said the organization “leads the way in rare plant species propagation and reintroduction
Our comprehensive approach encompasses seed collection
and field maintenance strategies to ensure successful reintegration of these precious species into our forest ecosystems.”
By preserving both the rare butterfly species and its essential host plant
this initiative demonstrates the vital connection between plant and animal conservation in maintaining healthy ecosystems
Presentation of the L Festival Flamenco from Tomares at the IAF
El Festival Flamenco City of Tomares, which is one of the oldest, most prestigious and long-standing in Andalusia, will celebrate its 50th anniversary in style, on Saturday, July 19 at 22 p.m., in Los Jardines del Conde del Tomares City Council
with a luxury line-up: with two of the greatest young national singers
and the director of the Andalusian Institute of Flamenco (IAF)
Festival that this year celebrates a very special date
half a century being a reference in the dissemination of deep art and beyond our borders
through which almost all the greats of the flamenco -Camarón
most prestigious and traditional in Andalusia
An event that also included the president of the Peña Flamenco Culture of Tomares
the president of the Provincial Federation of Seville of Flamenco Entities
the delegate for Major Festivals of the Tomares City Council
and some of the great figures who will be protagonists such as the singer María Terremoto
the dancer Manuela Carrasco and the guitarist The Pearl
"today is a reason for joy because we are presenting the lineup for the 50th edition of the Festival Flamenco Tomares in a privileged environment such as the one in which this beautiful building is located
headquarters of the Andalusian Institute of FlamencoCongratulations to the director of the Andalusian Institute of Flamenco
for how much and how well he is working for the flamenco in Andalusia
I want to highlight the importance that Culture and the Flamenco
something very much ours and we must give it the importance it deserves
"It is not easy for a peña turns fifty years old
nor does it have fifty editions of its festival flamenco"Every year we improve
which has become a benchmark in the province of Seville
“A great poster that I also want to thank the Peña Cultural Flamenca de Tomares
but this great poster is the result of the work of the Peña
It is not easy for a peña turns 50 years old
nor does it have 50 editions of its Festival FlamencoEvery year we improve
and we are on our way to becoming a benchmark Festival in Andalusia
and that is thanks to everyone's work and yours
I want to thank all the presidents who have passed through the peñaTimes have changed a lot
a group of friends who love flamenco How did you manage to carry out this great project such as the Peña Flamenco Cultural of Tomares"
the director of the Andalusian Institute of Flamenco
has specified that "the IAF has been chosen for the presentation of the L Festival Flamenco
defend and protect the flamencoCongratulations to the mayor of Tomares
for the excellent lineup and luxurious programming you've designed for the 50th edition of this festival
A lineup you've designed with the support of the local community
with the Peña Cultural Flamenca de Tomares
with the direct work you do with the others peñaYes
because from the Tomares City Council I attest
to the work you do for culture and flamenco
because you care about generating new audiences and the emergence of new talents
This work you do throughout the year and culminates in this Festival
according to the critic of flamenco Antonio Ortega
“with two artists who are at the top of the young ladder: María Terremoto and Israel Fernández
they were talked about as two diamonds in the rough
but now they are two young figures of the flamenco who are at the top
And it's a great blessing that they'll be sharing the bill with someone for whom she is a great role model: Manuela Carrasco
This means that those of us who will be taking to the stage on July 19th will not only bring our professionalism
but also all the love and affection; it's going to be a very special day
I don't want to forget to mention the amazing lineup that's been prepared for the finale
The closing party of the L Festival Flamenco Tomares will be played by El Perla on guitar
Tickets (25 euros) are on sale online at www.giglon.com and in person at the Peña Flamenco Cultural of Tomares (C/ José Monje Cruz Camarón de la Isla
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Students in the McCourt School’s client-based capstone course have analyzed hundreds of decades-old case files to advance research on exoneration
The Making an Exoneree program has amassed a database of more than 300 cases for consideration over the past six years
PJI partnered with graduate students in the McCourt School’s client-based capstone course to analyze the case files and provide guidance on data collection and organization for the future of the Making an Exoneree program
PJI previously partnered with McCourt School capstone students on program evaluation for its two re-entry programs: the Pivot Program and the MORCA-Georgetown Paralegal Program
PJI receives hundreds of cases that are reviewed by a small group of staff and students
Each case provides detailed information about the life and wrongful conviction of the potential exoneree
“We learn so much that is upsetting and unknowable,” said Danny Tomares (MPP‘23)
“There are counties and states where we don’t have any way of getting information and people whose stories will never be known.”
The McCourt students conduct extensive research and data analysis to assess different factors that impact the likelihood of a wrongful conviction
identifying commonalities or trends in PJI’s data and how it compares to national databases
“Finding patterns and understanding how they break down by age
the more patterns will tell you,” said Shira Davidson (MPP’23)
“It is strange to be brushing up against something so relevant,” said Tomares
who are so close to a case that is being discussed nationally
is an incredible opportunity that grounds innocence work in the real people who are behind the text and numbers on a screen.”
Building on the research conducted by the McCourt students
PJI hopes to increase its own understanding and scholarship of “a field where further research and collaboration are so important to bringing more justice to people who have been wrongfully convicted,” said Davidson
Metrics details
Bacterial Ribonucleoprotein bodies (BR-bodies) play an essential role in organizing RNA degradation via phase separation in the cytoplasm of bacteria
BR-bodies mediate multi-step mRNA decay through the concerted activity of the endoribonuclease RNase E coupled with the 3′-5′ exoribonuclease Polynucleotide Phosphorylase (PNPase)
studies indicated that the loss of PNPase recruitment into BR-bodies led to a significant build-up of RNA decay intermediates in Caulobacter crescentus
it remained unclear whether this is due to a lack of colocalized PNPase and RNase E within BR-bodies or whether PNPase’s activity is stimulated within the BR-body
We reconstituted RNase E’s C-terminal domain with PNPase towards a minimal BR-body in vitro to distinguish these possibilities
We found that PNPase’s catalytic activity is accelerated when colocalized within the RNase E biomolecular condensates
partly due to scaffolding and mass action effects
disruption of the RNase E-PNPase protein–protein interaction led to a loss of PNPase recruitment into the RNase E condensates and a loss of ribonuclease rate enhancement
We also found that RNase E’s unique biomolecular condensate environment tuned PNPase’s substrate specificity for poly(A) over poly(U)
reduces RNase E phase separation both in vitro and in vivo
This regulatory feedback ensures that under limited phosphate resources
PNPase activity is enhanced by recruitment into RNase E’s biomolecular condensates
a small domain (SD) and an intrinsically disordered region organized as a set of charged blocks
these in vivo experiments could not distinguish whether exoribonuclease recruitment to BR-bodies was responsible for the mRNA decay fragment build-up
or whether exoribonucleases have enhanced catalytic activity within BR-bodies
here we provide direct in vitro evidence to show PNPase’s localization within RNase E biomolecular condensates stimulates the catalytic rate of PNPase and regulates the RNA substrate specificity of PNPase
We then uncover how levels of a key PNPase enzymatic reactant and nutrient regulate phase separation
This logical wiring of PNPase biochemistry with RNase E phase separation provides a way to regulate RNA decay processes in fluctuating phosphate nutrients
These protein constructs allow us to consider how RNase E’s phase separation properties impact PNPase activity
We visualized each mixture via phase contrast and fluorescence microscopy imaging to determine if the purified RNase E CTD-YFP could recruit PNPase-mcherry as a client
We then calculated the fluorescence intensity ratio in the concentrated versus the dilute phase for each assembly
Differences in the degree of protein enrichment in the dense phase directly vary the fluorescence intensity
the unique chemical environment or these assemblies may alter the refractive index or impact the quantum yield of fluorescent proteins
the crowding of fluorescent proteins nearby may lead to quenching the fluorescence signal
the PR reflects the combinations of these effects
PNPase partitions into RNase E biomolecular condensates by interacting with a C-terminal binding site on RNase E-CTD
We found that PNPase enrichment into RNase E condensates was mediated by a specific protein–protein interaction
(a) Phase-contrast and fluorescence microscopy images of RNase E biomolecular condensates
RNase E and RNase E-∆PNP-BS contained a C-terminal eYFP tag and were present at 20 µM
and PNPase-ASM (active site mutant) contained a C-terminal mCherry tag and was at a concentration of 1 µM
(b) Average partitioning ratios and standard deviations are presented for RNase E
There is no statistically significant difference between any PRs (p > 0.05)
(c) Average partitioning ratios and standard deviations are presented for PNPase
PNPase is only significantly recruited into RNase E biomolecular condensates (p < 0.001)
PNPase does not significantly partition into RNase E biomolecular condensates (p > 0.05)
(d) Average droplet circularity and standard deviations
See the methods section for the droplet circularity calculation formula
Data represent the average and standard deviation of n > 300 droplets from three replicates of images
PNPase requires the 10 C-terminal residues of RNase E for enrichment within RNase E condensates
This suggests weak fluorescent protein interactions can contribute to RNase E condensate morphology changes
(b) Phase-contrast and fluorescence microscopy images of RNase E biomolecular condensates mixed with PNPase-ASM-mCherry or the PNPase-V104A/E224A/F233A-mCherry variant
(c) Average partitioning ratios and standard deviations are presented for PNPase and the PNPase-V104A/E224A/F233A-mCherry variant
The PNPase-V104A/E224A/F233A-mCherry variant does not significantly partition into RNase E biomolecular condensates (p > 0.05)
Data represent the average and standard deviation of three replicates
These results indicate that the GWW peptide outcompetes the C-terminus of RNase E for binding with PNPase
lowering the amount of PNPase associated with the RNase E condensates
These results suggest the potential of short peptides functioning as inhibitors to disrupt PNPase client recruitment into RNase E condensates
These results suggest that poly(A) has a poor capacity to recruit PNPase and that the protein–protein interaction with the C-terminus of RNase E is likely the main driver of PNPase recruitment into RNase E condensates
RNase E biomolecular condensates stimulate the ribonuclease functions of PNPase
Here we found that PNPase recruitment into the RNase E condensates stimulated PNPase’s degradation of poly(A) substrates
we found the addition of the maltose-binding protein (MBP) tag to RNase E solubilized the RNase E condensates
We found that MBP-RNase E did not stimulate PNPase ribonuclease functions to the same level
suggesting a role of RNase phase-separated environment upon PNPase stimulation
(a) Rate of ribonuclease activity towards 25 ng/µL poly(A) for 5 µM PNPase alone
5 µM PNPase and 20 µM RNase E-∆BS (RNase E lacking the 14 C-terminal amino acids to which PNPase binds)
and 5 µM PNPase and 20 µM MBP-RNase E (Maltose Binding Protein-RNase E fusion which cannot phase separate)
(b) Ribonuclease activity of PNPase-V104A/E224A/F233A-mCherry (PNPase triple mutant lacking the ability to bind RNase E) and PNPase-V104A/E224A/F233A-mCherry mixed with RNase E
No significant rate increase was observed when RNase E was added (p > 0.05)
(c) Phase contrast and fluorescence microscopy images of RNase E CTD-YFP versus RNase E MBP-CTD-YFP
Fusion of maltose-binding protein (MBP) significantly reduced the phase separation properties of RNase E
(d) Ribonuclease activity towards 25 ng/µL poly(U) for five µM PNPase alone
No significant difference in rate was observed (p > 0.05)
(e) Ribonuclease activity of 5 µM PNPase after incubation with 10 µM or 100 µM GWW peptide
(f) RNase E droplet formation stimulates PNPase polymerase activity
The rate of PNPase polymerization of ADP into poly(A) is faster in the presence of RNase E droplets than with PNPase alone
PNPase activity is not enhanced when the recruitment of PNPase to RNase E droplets is diminished (RNase E CTD∆BS) or when RNase E cannot form droplets (RNase E MBP-CTD)
Data represent the average and standard deviation of at least three trials
We next assessed how the phase-separated environment of RNase E impacted PNPase function. The PNPase-RNase E co-assembly degraded poly(A) at a rate of 274 ± 60 µg min−1 (mg PNPase)−1. This corresponds to a 3.4-fold enhancement of the rate of poly(A) degradation over PNPase alone (p < 0.001) (Fig. 4a)
This result indicates that a direct interaction between RNase E and PNPase is required for the 3.4-fold rate enhancement of poly-A degradation
In summary, we have considered the impact of the disruption of the RNase E-PNPase interaction through both RNase E variants (Fig. 4a) and PNPase variants (Fig. 4b)
Both variants lead to a loss of PNPase recruitment into the RNase E condensates and a failure to stimulate PNPase’s breakdown of poly (A)
These results suggest that the specific protein–protein interaction of RNase E’s C-terminal residues enhances
One consideration in these assays was the ratio of RNase E:PNPase
the copy numbers of RNase E range from 10 to 20 µM
We examined assays at a 20:5 ratio of RNase E: PNPase to bias PNPase to be in its condensate-bound form
lower PNPase concentrations ensure that the initial reaction rates are sufficiently slow for enzymatic characterization to distinguish condensate bound and free forms of PNPase
We anticipate varied stoichiometry of this complex will also lead to optimizing this rate enhancement to ensure each RNase E scaffold engages one RNA substrate and one PNPase client
crescentus PNPase alone has no substrate preference for poly(A) or poly(U)
This increased enrichment suggests that the substrate selectivity of PNPase in the presence of RNase E is impacted by the increased poly(A) enrichment relative to poly(U)
This suggests that there may also be contributions in how poly(A) and poly(U) impact the viscosity of the RNase E-PNPase condensates
we considered if PNPase’s polymerase activity could be stimulated by RNase E CTD variants that do not colocalize with the RNase E condensates
We found that PNPase polymerized ADP at a rate of 110 ± 6 mmol min−1 mg PNPase−1 in the presence of condensates formed from RNase E-∆PNP BS
which was not significantly different from the polymerase activity of PNPase alone (p = 0.66)
PNPase polymerized ADP at a rate of 106 ± 12 mmol ADP min−1 mg PNPase−1 and is not significantly different from PNPase alone (p = 0.87)
the phase-separated environment has a mild 1.5-fold impact on PNPase polymerase activity
These data suggest that the observed RNase E biomolecular condensates in cells are sites of RNA degradation instead of sites of polymerase activity
We next considered three mechanisms for how RNase E could stimulate PNPase phosphorylase activity
The first is that RNase E’s C-terminal binding site allosterically activates PNPase
RNase E brings PNPase and poly(A) nearby via scaffolding
stimulating enhanced exoribonuclease activity
a third model considers the unique chemical environment of biomolecular condensates that concentrates both poly(A) and PNPase
This third model builds upon the scaffolding effect to include the impact of a higher concentration of PNPase and poly(A) in the RNase E biomolecular condensates
thereby increasing the kinetics of PNPase through mass action
To test allostery without phase separation and scaffolding, we incubated PNPase with the GWW peptide from RNase E for 30 min before measuring exonuclease activity against poly(A). There was no significant difference in PNPase activity when 10 or 100 µM of the peptide was added (p > 0.05) (Fig. 4e)
indicating that the RNase E GWW peptide does not allosterically activate PNPase
While this known direct interaction between the GWW peptide and PNPase does not stimulate PNPase function
the full-length RNase E may make additional unknown contacts with PNPase that mediate allosteric regulation
Analysis of these constructs suggests that scaffolding in the dilute phase increases PNPase activity twofold
one caveat for using a MBP fusion is that the bulky MBP tag may exert other steric effects upon the RNase E-PNPase complex in addition to diminished phase separation
High sodium phosphate or low magnesium chloride levels dissolve the RNase E biomolecular condensates
Caulobacter crescentus lives in diverse environmental conditions with fluctuating nutrients such as magnesium and phosphate
We found that low phosphate levels stimulate RNase E phase separation in vivo and in vitro
whereas high levels of phosphate lead to the dissolution of the RNase E biomolecular condensates
(a) We considered the logic of how PNPase’s biochemistry is connected to RNase E’s phase separation
PNPase utilizes a magnesium ion cofactor to catalyze the phosphorolysis of a single nucleotide (AMP) by adding inorganic phosphate to release nucleoside diphosphates (ADP)
(b) Phase-contrast images of RNase E biomolecular condensates in 0 mM or 10 mM sodium phosphate
(c) Turbidity measurement at 340 nm of 20 µM RNase E in a titration of magnesium chloride or sodium phosphate
(d) Phase-contrast images of RNase E biomolecular condensates mixed with 1 mM poly(A) 5-mer
(e) Rate of ribonuclease activity towards 25 ng/µL poly(A) for 5 µM PNPase alone or 5 µM PNPase and 20 µM RNase E in 10 mM sodium phosphate that does not form phase-separated assemblies
(f) Effect of increased phosphate on BR-bodies in vivo
(g) The average number of foci when cells are grown in Higgs medium supplemented with 30 µM and 1 mM phosphate
Error bars represent the standard deviation from three biological replicates
We proposed that protein–protein interactions between RNase E’s positively and negatively charged blocks play a key role in RNase E’s homotypic phase separation
Whereas RNase E’s positively charged block interaction with negatively charged RNA regulates its RNA-stimulated phase separation
we speculate that the negatively charged phosphates interact with the positively charged blocks in a way that competes with and disrupts key multivalent interactions that drive RNase E’s phase separation
Phosphate ions may also directly compete for binding to the same interaction motifs
or phosphate ions may alter RNase E’s conformation to prevent multivalent interactions
Delineation of these models will require future structural studies to identify the multivalent interaction that mediates RNase E phase separation
While 6 mM sodium phosphate was sufficient to drive the dissolution of RNase E droplets
the equivalent ionic strength of sodium chloride was not sufficient to dissolve RNase E droplets
this effect is not generally applicable to all divalent anions since sodium sulfate's equivalent ionic strength was insufficient to dissolve RNase E droplets
To further decouple the effect of phosphate from sodium
we titrated the potassium salts of chloride
potassium phosphate drove the dissolution of RNase E droplets
while the equivalent ionic strength of potassium chloride or potassium sulfate did not
Given the impact of high phosphate on the dissolution of RNase E biomolecular condensates, we also hypothesized that RNase E would no longer stimulate PNPase’s activity under high phosphate conditions. Indeed, in 10 mM sodium phosphate, we found that the activity of PNPase was unaltered by adding RNase E (Fig. 5e)
This adds an additional line of evidence that RNase E’s phase separation properties are critical to its ability to enhance PNPase functions
the sensitivity of RNase E’s phase separation and PNPase regulation capabilities suggest that cytosolic phosphate concentrations may impact BR-body formation in vivo
This indicates that ADP products of PNPase nuclease activity do not directly regulate RNase E’s phase separation
The ability to avoid biomolecular condensate dissolution at high levels of ADP may be critical to maintaining the enhanced RNA decay within these assemblies
The addition of these short poly(A) oligos did not cause the dissolution of RNase E droplets
These results indicate that the ribonuclease activity products of PNPase do not cause RNase E biomolecular condensates to dissolve
The logical wiring of RNase E condensate phase separation with PNPase enzymatic functions
Our studies found that RNase E phase separation is sensitive to a critical reactant
High phosphate nutrients dissolve RNase E CTD condensates in vitro
Low phosphate nutrients stimulate phase separation and PNPase activity when the concentration of this critical phosphate nutrient is low
Thus the availability of phosphate nutrients provides a negative feedback loop upon the regulation of RNase E condensate formation and function
Our previous work has shown that RNA substrate availability stimulates BR-body formation
RNA substrates provide a positive feedback loop that provides on-demand highly active RNase E condensates
Our current simplified system of RNase E’s CTD and PNPase has allowed us to examine the effects of RNase E upon PNPase
our studies are limited by the simplicity of the RNase E-CTD-PNPase assemblies versus the full compositional of BR-bodies in vivo
the full-length RNase E additionally includes the N-terminal endoribonuclease domains and a binding site for the DEAD-box RNA helicase RhlB
This full-degradosome brings the capacity to the breakdown of structured RNA that require RNase E’s endoribonuclease activity followed by the exoribonuclease activity of PNPase
we expect the degradation rates of structured RNAs by PNPase alone to be very low
adding full-length RNase E and RhlB’s capacity to unwind structured RNA substrates would likely lead to significantly higher rate enhancements
in the context of structured RNA substrates that require a two-step decay process
we suspect that co-localization of RNase E and PNPase is critical to channel the RNA intermediates from RNase E to PNPase and minimize RNA intermediate half-life
In the absence of full-length RNase E localization with PNPase
RNA decay intermediates that RNase E has initially degraded are expected to have a longer half-life before encountering the downstream PNPase enzyme
The addition of the remaining clients (RNase D
and RhlB) will very likely alter some of the protein–protein interactions within the condensate and may introduce new interactions
The full degradosome's altered multivalent interaction networks may have a different chemical environment than the CTD alone
This full degradosome chemical environment may impact viscosity
increase crowding due to fully populated degradosome
access RNA substrates to the ribonuclease enzymes
and could further refine substrate selectivity
Future comparison of unoccupied RNase E biomolecular condensates to BR-bodies with partial client occupancy to full client occupancy will yield considerable insights into the systems biology of BR-bodies
This may suggest that long contiguous stretches of adenosine display preferences over isolated adenosine bases amongst oligoribonucleotide substrates
results suggest that BR-bodies can fine-tune the half-lives of RNAs in cells and that polyadenylation may shape the available transcriptome
future studies will be needed to examine the interplay of polyadenylation and BR-body functions in vivo and in vitro
The coupling of enzyme recruitment and enzyme regulation enabled the spatial regulation of PleC function
Our studies suggest that systematically evaluating biomolecular condensate effects through selective scaffolding
and allostery can reveal how biomolecular condensates fine-tune enzyme functions
Changes in the media’s phosphate concentrations may also increase PNPase activity clearing RNAs from cells
crescentus in high phosphate would result in more ribosomes competing with BR bodies
phosphate nutrient availability regulates BR phase separation and access to RNA substrates
PNPase activity may be too low to drive the decay of RNAs
low phosphate conditions in the presence of nucleotide diphosphates may bias PNPase's function as a polymerase
This presents significant evolutionary constraints on microorganisms that live in low phosphate nutrient conditions
This critical phosphate-BR-body feedback loop ensures robust PNPase activity as Caulobacter crescentus endures fluctuating availability of phosphate nutrients in the environment
The mechanism of how phosphates dissolve RNase E condensates will require understanding the RNase E phase separation mechanism
We currently propose that protein–protein interactions between RNase E’s positively and negatively charged blocks play a key role in RNase E’s homotypic phase separation
Whereas in RNA-stimulated phase separation
RNase E’s positively charged block interacts with negatively charged RNA
This competition could be direct competition for binding to the same interaction motifs
where salts may alter RNase E’s conformation to prevent multivalent interactions
Delineating these models will require understanding the multivalent interaction mediating RNase E phase separation
PNPase shares similarities to this example
as its key substrate (phosphate) also attenuates RNase E phase separation at high concentrations
RNA substrate availability is also required to form BR-bodies in vivo
This collectively suggests that substrate-mediated positive and negative feedback loops may commonly regulate phase separation in cells
both RNase E and SpmX biomolecular condensates are sensitive to phosphate nutrient availability
RNase E phase separation is directly sensitive to phosphate levels
whereas the SpmX condensates are sensitive to cellular ATP levels
These studies highlight the intricate logical wiring of biomolecular condensate biochemistry and material properties with nutrient availability
Plasmid pMJC0095 was constructed to express PNPase from C
crescentus with an N-terminal 6x-His-tag and a C-terminal mCherry
Plasmid pTEV5-PNPase-mCherry was transformed into chemically competent Rosetta (DE3) cells and plated onto LB-Miller plates supplemented with 50 mg/mL chloramphenicol
100 mg/mL ampicillin and incubated overnight at 37 °C
an overnight 60 mL LB-Miller culture (30 mg/mL chloramphenicol
50 mg/mL ampicillin) was inoculated and incubated at 37 °C
6 L of LB-Miller media (30 mg/mL chloramphenicol
50 mg/mL ampicillin) was inoculated with 6 mL of the saturated culture and grown to mid-log phase (~ 0.5 OD600)
Expression of PNPase-mCherry was induced with 333 µM isopropyl-β-d-1-thiogalactopyranoside (IPTG) for 4 h at 25 °C
The cells were collected by centrifugation at 4 °C
The resulting pellet was washed with 60 mL resuspension buffer (50 mM Tris pH 7.5
500 mM NaCl) before being pelleted again at 4 °C
The cell pellet was thawed on ice and then resuspended in 10 mL lysis buffer per liter of culture (20 mM Tris HCl pH 7.5
200 U benzonase) supplemented with SigmaFast protease inhibitor tablets (Sigma)
The cell suspension was lysed by continuous passage through an Avestin Emulsiflex-C3 at 15,000 psi for 15 min at 4 °C
Cell debris was pelleted by centrifugation at 29,000g for 45 min at 4 °C
The supernatant was loaded onto a HisTrap FF column (GE Healthcare) and washed with 20 column volumes of wash buffer (20 mM Tris HCl pH 7.5
Then was eluted with elution buffer (20 mM Tris HCl pH 7.5
Fractions containing PNPase were supplemented with 50 mM sodium phosphate (pH 7.5) at 37 °C for 1 h to drive phosphorolysis of co-purifying RNA
The fractions were loaded onto a G-Sep™ 6–600 kDa Size Exclusion Columns (G-Biosciences) and eluted with storage buffer (20 mM Tris HCl pH 7.5
Fractions containing PNPase were concentrated using 50,000 MWCO Amicon centrifugal filters to 15.5 mg/mL
and flash-frozen in liquid nitrogen and stored at − 80 °C
Cells were thawed on ice and then resuspended in 10 mL lysis buffer per liter of culture (20 mM Tris HCl pH 7.5
0.1% Triton X-100) supplemented with SigmaFast protease inhibitor tablets (Sigma)
the purification was eluted with elution buffer (20 mM Tris HCl pH 7.5
Fractions containing RNase E were loaded onto a G-Sep™ 6–600 kDa Size Exclusion Columns (G-Biosciences) and eluted with storage buffer (20 mM Tris HCl pH 7.5
Fractions containing RNase E were concentrated using 50,000 MWCO Amicon centrifugal filters to 18.6 mg/mL
flash-frozen in liquid nitrogen and stored at − 80 °C
MBP-RNase E-CTD-eYFP was purified similarly to RNase E-CTD-eYFP through the nickel affinity chromatography step
After MBP-RNase E-CTD-eYFP was eluted from the HisTrap column
the protein was desalted using a PD-10 column (GE healthcare) with heparin column binding buffer (20 mM Tris HCl pH 7.5
10% glycerol) before passage over a heparin column (Cytiva)
MBP-RNase E-CTD-eYFP was eluted with heparin elution buffer (20 mM Tris HCl pH 7.5
Protein was then buffer exchanged into storage buffer (20 mM Tris HCl pH 7.5
concentrated using 50,000 MWCO Amicon centrifugal filters to 23.5 mg/mL
and flash-frozen in liquid nitrogen before storage at − 80 °C
to which was added protein and poly(A) at the necessary concentrations specified in each experiment
Imaging samples were pipetted into a 1 mm well formed by an adhesive spacer (Electron Microscopy Sciences) affixed to a microscope slide (VWR) and sealed with a glass coverslip (VWR)
Slides were inverted and allowed to sit at room temperature for 30 min before imaging on a Nikon Eclipse Ti-E inverted microscope with a Plan Apo-(lambda) 100×/1.45 oil objective and 518F immersion oil (Zeiss)
Excitation filter cubes CFP/YFP/mChy (77074157) and Cy5 (77074160) from Chroma and emission filter sets CFP/YFP/mChy (77074158)
and Cy5 (77074161) from Chroma were used for fluorescence imaging with a Spectra X light engine from Lumencor
Images were taken with an Andor Ixon Ultra 897 EMCCD camera
Images were analyzed with Fiji using a gaussian blur image subtraction and Renyi Entropy threshold method to find droplet boundaries
The mean signal from each droplet area was divided by the mean signal of the non-droplet area to give a partitioning ratio for each droplet
which is averaged to give a partitioning ratio for each experimental condition
Droplet circularity was measured in Fiji using the formula circularity = 4 * π * (area/perimeter2)
the tolerance and Z-score were set to 160 and 18
The ionic strength of solutions was calculated using the following equation:
Turbidity reaction mixtures contained 20 mM Tris pH 7.5
The magnesium titration trial contained 4 mM PO4 pH 7.5
and the phosphate titration trial contained 20 mM MgCl2
The absorbance at 340 nm of triplicate samples was recorded with a Tecan M200Pro microplate reader (Tecan Group Ltd.)
A background sample containing only buffer was collected and subtracted from each sample
Fluorescent polynucleotides were generated using 5 µM PNPase with 99 µM NDP and 1 mM ADP-Cy5 in a buffer of 20 mM Tris pH 7.5
Reactions were run for 2 h at room temperature
Fluorescent polynucleotides were purified using silica gel spin columns and frozen at − 80 °C for future use
RNA degradation assays were performed at room temperature in 20 mM Tris–HCl (pH 7.5)
and 0.5 mM DTT with 5 µM purified PNPase and 20 µM purified RNase E
Reactions were initiated by adding 25 ng/µL poly(A) RNA
aliquots were withdrawn and quenched in 100 mM EDTA
Samples were denatured in 1.5 volumes of 2 × RNA loading buffer containing 95% formamide
and 0.025% SDS and incubated at 95 °C for 3 min
Quenched ribonuclease reaction aliquots were loaded onto a pre-run 6% acrylamide gel containing 7 M urea
The gel was run in 1 × TBE (89 mM Tris base
89 mM boric acid) at 250 V at room temperature to separate RNA
the gel was rinsed in Milli-Q water for 5 min and stained for 20 min with 1 × SYBR gold nucleic acid stain (Invitrogen) in 1 × TBE
Each gel assay included RNA-only and protein-only controls
Gels were imaged with BioRad ChemiDoc™ MP imager using SYBR gold settings and quantified using the BioRad ImageLab software package
The intensity of the protein-only lane was subtracted from each timepoint lane intensity and plotted against time
The degradation rate was calculated in relation to a known amount of RNA added in an RNA-only control lane and divided by the amount of protein to give rates in µg min−1 (mg PNPase)−1
nuclease activity cannot be reported on a molar scale
The 10 C-terminal residues of Caulobacter crescentus RNase E (EKPRRGWWRR) (GWW peptide) were synthesized by GenScript with C-terminal amidation and dissolved in Milli-Q water and frozen at − 80 °C until further use
In RNA-degradation assays containing GWW peptide
the peptide was added to the reaction tube with buffer and PNPase and incubated at room temperature for 30 min to allow the peptide to associate with PNPase
Reactions were otherwise carried out as described previously
Graph-pad Prism 9 software for Mac was used for statistical analysis
The analysis of variance (ANOVA) test was used to evaluate the significant differences between conditions
where a p ≤ 0.05 was considered significant
Data for enzyme rate analysis represents the mean and standard deviation of three replicates
Data for partition ratio analysis represents the mean and standard deviation of at least 18 images taken from at least three replicates
Tukey’s multiple comparisons test was used to determine significant differences between groups
The datasets used and/or analyzed in this study are available from the corresponding author on reasonable request
Fare, C. M., Villani, A., Drake, L. E. & Shorter, J. Higher-order organization of biomolecular condensates. Open Biol. 11, 210137. https://doi.org/10.1098/rsob.210137 (2021)
Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Biomolecular condensates: Organizers of cellular biochemistry. Nat. Rev. Mol. Cell Biol. 18, 285–298. https://doi.org/10.1038/nrm.2017.7 (2017)
Brangwynne, C. P., Tompa, P. & Pappu, R. V. Polymer physics of intracellular phase transitions. Nat. Phys. 11, 899–904. https://doi.org/10.1038/nphys3532 (2015)
Li, P. et al. Phase transitions in the assembly of multivalent signalling proteins. Nature 483, 336–340. https://doi.org/10.1038/nature10879 (2012)
Lin, Y., Protter, D. S. W., Rosen, M. K. & Parker, R. Formation and maturation of phase-separated liquid droplets by RNA-binding proteins. Mol. Cell 60, 208–219. https://doi.org/10.1016/j.molcel.2015.08.018 (2015)
Lafontaine, D. L. J., Riback, J. A., Bascetin, R. & Brangwynne, C. P. The nucleolus as a multiphase liquid condensate. Nat. Rev. Mol. Cell Biol. 22, 165–182. https://doi.org/10.1038/s41580-020-0272-6 (2021)
Currie, S. L. & Rosen, M. K. Using quantitative reconstitution to investigate multicomponent condensates. RNA 28, 27–35. https://doi.org/10.1261/rna.079008.121 (2022)
Su, X. et al. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science 352, 595–599. https://doi.org/10.1126/science.aad9964 (2016)
Ditlev, J. A. et al. A composition-dependent molecular clutch between T cell signaling condensates and actin. Elife https://doi.org/10.7554/eLife.42695 (2019)
Rao, N. N., Gómez-García, M. R. & Kornberg, A. Inorganic polyphosphate: Essential for growth and survival. Annu. Rev. Biochem. 78, 605–647. https://doi.org/10.1146/annurev.biochem.77.083007.093039 (2009)
Kornberg, A. Inorganic polyphosphate: Toward making a forgotten polymer unforgettable. J. Bacteriol. 177, 491–496. https://doi.org/10.1128/jb.177.3.491-496.1995 (1995)
Boutte, C. C., Henry, J. T. & Crosson, S. ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus. J. Bacteriol. 194, 28–35. https://doi.org/10.1128/jb.05932-11 (2012)
Rao, N. N. & Kornberg, A. Inorganic polyphosphate supports resistance and survival of stationary-phase Escherichia coli. J. Bacteriol. 178, 1394–1400. https://doi.org/10.1128/jb.178.5.1394-1400.1996 (1996)
Brangwynne, C. P. et al. Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science 324, 1729–1732. https://doi.org/10.1126/science.1172046 (2009)
Beaufay, F. et al. Polyphosphate drives bacterial heterochromatin formation. Sci. Adv. 7, eabk0233. https://doi.org/10.1126/sciadv.abk0233 (2021)
Azaldegui, C. A., Vecchiarelli, A. G. & Biteen, J. S. The emergence of phase separation as an organizing principle in bacteria. Biophys. J. 120, 1123–1138. https://doi.org/10.1016/j.bpj.2020.09.023 (2021)
Cohan, M. C. & Pappu, R. V. Making the case for disordered proteins and biomolecular condensates in bacteria. Trends Biochem. Sci. 45, 668–680. https://doi.org/10.1016/j.tibs.2020.04.011 (2020)
Heinkel, F. et al. Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 116, 16326–16331. https://doi.org/10.1073/pnas.1820683116 (2019)
Harami Gábor, M. et al. Phase separation by ssDNA binding protein controlled via protein−protein and protein−DNA interactions. Proc. Natl. Acad. Sci. 117, 26206–26217. https://doi.org/10.1073/pnas.2000761117 (2020)
Jin, X. et al. Membraneless organelles formed by liquid-liquid phase separation increase bacterial fitness. Sci. Adv. 7, eabh2929. https://doi.org/10.1126/sciadv.abh2929 (2021)
Robles-Ramos, M. Á. et al. Assembly of bacterial cell division protein FtsZ into dynamic biomolecular condensates. Biochim. Biophys. Acta Mol. Cell Res. 1868, 118986. https://doi.org/10.1016/j.bbamcr.2021.118986 (2021)
Ma, J. et al. Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch. EMBO J. 40, e107500. https://doi.org/10.15252/embj.2020107500 (2021)
Pattanayak, G. K. et al. Daily cycles of reversible protein condensation in cyanobacteria. Cell Rep. 32, 108032. https://doi.org/10.1016/j.celrep.2020.108032 (2020)
Wang, H. et al. Rubisco condensate formation by CcmM in beta-carboxysome biogenesis. Nature 566, 131–135. https://doi.org/10.1038/s41586-019-0880-5 (2019)
MacCready, J. S., Basalla, J. L. & Vecchiarelli, A. G. Origin and evolution of carboxysome positioning systems in cyanobacteria. Mol. Biol. Evol. 37, 1434–1451. https://doi.org/10.1093/molbev/msz308 (2020)
Al-Husini, N., Tomares, D. T., Bitar, O., Childers, W. S. & Schrader, J. M. α-proteobacterial RNA degradosomes assemble liquid-liquid phase-separated RNP bodies. Mol. Cell 71(6), 1027-1039.e1014. https://doi.org/10.1016/j.molcel.2018.08.003 (2018)
Al-Husini, N. et al. BR-bodies provide selectively permeable condensates that stimulate mRNA decay and prevent release of decay intermediates. Mol. Cell 78, 670-682.e678. https://doi.org/10.1016/j.molcel.2020.04.001 (2020)
Janissen, R. et al. Global DNA compaction in stationary-phase bacteria does not affect transcription. Cell 174, 1188-1199.e1114. https://doi.org/10.1016/j.cell.2018.06.049 (2018)
Hondele, M. et al. DEAD-box ATPases are global regulators of phase-separated organelles. Nature 573, 144–148. https://doi.org/10.1038/s41586-019-1502-y (2019)
Ladouceur, A.-M. et al. Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation. Proc. Natl. Acad. Sci. 117, 18540–18549. https://doi.org/10.1073/pnas.2005019117 (2020)
Muthunayake, N. S., Tomares, D. T., Childers, W. S. & Schrader, J. M. Phase-separated bacterial ribonucleoprotein bodies organize mRNA decay. WIREs RNA 11, e1599. https://doi.org/10.1002/wrna.1599 (2020)
Hardwick, S. W., Chan, V. S., Broadhurst, R. W. & Luisi, B. F. An RNA degradosome assembly in Caulobacter crescentus. Nucleic Acids Res. 39, 1449–1459. https://doi.org/10.1093/nar/gkq928 (2011)
Worrall, J. A. R. et al. Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome. J. Mol. Biol. 382, 870–883. https://doi.org/10.1016/j.jmb.2008.07.059 (2008)
Reconstitution of a minimal RNA degradosome demonstrates functional coordination between a 3′ exonuclease and a DEAD-box RNA helicase
Khemici, V., Poljak, L., Toesca, I. & Carpousis Agamemnon, J. Evidence in vivo that the DEAD-box RNA helicase RhlB facilitates the degradation of ribosome-free mRNA by RNase E. Proc. Natl. Acad. Sci. 102, 6913–6918. https://doi.org/10.1073/pnas.0501129102 (2005)
Blum, E., Carpousis, A. J. & Higgins, C. F. Polyadenylation promotes degradation of 3′-structured RNA by the Escherichia coli mRNA degradosome in vitro. J. Biol. Chem. 274, 4009–4016. https://doi.org/10.1074/jbc.274.7.4009 (1999)
Hardwick, S. W., Gubbey, T., Hug, I., Jenal, U. & Luisi, B. F. Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly. Open Biol. 2, 120028. https://doi.org/10.1098/rsob.120028 (2012)
Sulewski, M., Marchese-Ragona, S. P., Johnson, K. A. & Benkovic, S. J. Mechanism of polynucleotide phosphorylase. Biochemistry 28, 5855–5864. https://doi.org/10.1021/bi00440a023 (1989)
Amin, N. & Peterkofsky, A. A dual mechanism for regulating cAMP levels in Escherichia coli. J. Biol. Chem. 270, 11803–11805. https://doi.org/10.1074/jbc.270.20.11803 (1995)
Onuchic, P. L., Milin, A. N., Alshareedah, I., Deniz, A. A. & Banerjee, P. R. Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates. Sci. Rep. 9, 12161. https://doi.org/10.1038/s41598-019-48457-x (2019)
Peeples, W. & Rosen, M. K. Mechanistic dissection of increased enzymatic rate in a phase-separated compartment. Nat. Chem. Biol. 17, 693–702. https://doi.org/10.1038/s41589-021-00801-x (2021)
O’Hara, E. B. et al. Polyadenylylation helps regulate mRNA decay in Escherichia coli. Proc. Natl. Acad. Sci. 92, 1807–1811. https://doi.org/10.1073/pnas.92.6.1807 (1995)
Ingle Caroline, A. & Kushner Sidney, R. Development of an in vitro mRNA decay system for Escherichia coli: Poly(A) polymerase I is necessary to trigger degradation. Proc. Natl. Acad. Sci. 93, 12926–12931. https://doi.org/10.1073/pnas.93.23.12926 (1996)
Ohta, N., Sanders, M. & Newton, A. Characterization of unstable poly (A)-RNA in Caulobacter crescentus. Biochem. Biophys. Acta. 517, 65–75. https://doi.org/10.1016/0005-2787(78)90034-5 (1978)
Zhang, C., Zhao, W., Duvall, S. W., Kowallis, K. A. & Childers, W. S. Regulation of the activity of the bacterial histidine kinase PleC by the scaffolding protein PodJ. J. Biol. Chem. 298, 101683. https://doi.org/10.1016/j.jbc.2022.101683 (2022)
Saurabh, S. et al. ATP-responsive biomolecular condensates tune bacterial kinase signaling. Sci. Adv. 8, eabm6570. https://doi.org/10.1126/sciadv.abm6570 (2022)
Poindexter, J. S. Selection for nonbuoyant morphological mutants of Caulobacter crescentus. J. Bacteriol. 135, 1141–1145. https://doi.org/10.1128/jb.135.3.1141-1145.1978 (1978)
Ducret, A., Quardokus, E. M. & Brun, Y. V. MicrobeJ, a tool for high throughput bacterial cell detection and quantitative analysis. Nat. Microbiol. 1, 16077. https://doi.org/10.1038/nmicrobiol.2016.77 (2016)
Patel, A. et al. ATP as a biological hydrotrope. Science 356, 753–756. https://doi.org/10.1126/science.aaf6846 (2017)
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Creative Artists Agency announced the promotion of four to agents or executives on Friday
Brandon Lawrence has been promoted to agent in CAA’s TV department
while Ashley Feagan has been promoted to agent in CAA Sports’ Talent Sales group
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Counties across the country are now "open for solar business." This phrase sums up the Department of Energy-funded SolSmart program's core mission to help local governments adopt the most efficient policies so the booming solar industry can deliver to our communities
The changing industrial and technological landscape has driven down the costs of solar electricity generation in recent years
but “soft costs” to pay for business processes or administrative delays make up approximately 64 percent of these expenses
Reducing these costs by streamlining bureaucratic requirements can save time and money for community members
NACo has written before about SolSmart’s cost-free technical assistance
driven by a dedicated support team and templates for adopting best practices
the team helps our counties to find the appropriate pathway and to map the needed steps to carry your community to Bronze
Gold and - newly – Platinum designations reflective of the level of simplified administrative burdens
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offering planning and zoning training and making available resources that include a map showing over 2,000 solar installations by location and municipality
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Biomolecular condensates are membraneless hubs of condensed proteins and nucleic acids within cells
which researchers are realizing are tied to an increasing number of cellular processes and diseases
Studies of biomolecular condensate formation have uncovered layers of complexity
including their ability to behave like a viscoelastic material
the molecular basis for this putty-like property was unknown
Through a multi-institution collaboration, researchers at Washington University in St. Louis, St. Jude Children’s Research Hospital and State University of New York at Buffalo examined the interaction networks within condensates to better define the rules associated with their unique material properties. Published in Nature Physics
the results quantify the timescales associated with these interactions
explaining why condensates act like a molecular putty and how they can “age” into a viscoelastic solid more akin to a rubber ball
“Condensates have often been described as liquid-like, but their material properties can actually vary quite a bit,” explained Tanja Mittag, of the Department of Structural Biology at St. Jude, who collaborated on this research with WashU’s Rohit Pappu
“That depends on the sequences of the proteins within them and the lifetime of the interactions being formed.”
Beare Distinguished Professor at the McKelvey School of Engineering
Jude and partners at Buffalo to establish how condensates act as reaction hubs to organize biomolecules in cells spatially
Current efforts build upon years of research into the “molecular grammar” of biomolecular condensates
the rules that dictate how molecules organize themselves through the process of phase separation
The group further probed how condensates age
changing their material properties over time
Visit the St. Jude Children’s Research Hospital website to learn more
Alshareedah I, Borcherds WM, Cohen SR, Singh A, Posey AE, Farag M, Bremer A, Strout GW, Tomares DT, Pappu RV, Mittag T, Banerjee PR. Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates. Nature Physics, July 2, 2024. https://doi.org/10.1038/s41567-024-02558-1
This work was supported by the US National Institutes of Health through grants R01NS121114 (T.M
Jude Children’s Research Collaborative on the Biology and Biophysics of RNP Granules (P.R.B.
acknowledges support from the US National Institutes of Health (T32 EB028092)
We thank George Campbell from the Cell and Tissue Imaging Center at SJCRH
which is supported by SJCRH and NCI (grant P30 CA021765) for assistance with the DIC and confocal microscopy
We acknowledge the Washington University Center for Cellular Imaging (WUCCI)
which is supported by the Washington University School of Medicine
The Children’s Discovery Institute of University and St
Louis Children’s Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642)
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Defending champion Primoz Roglic suffered a nasty fall as Denmark's Mads Pedersen won stage 16 of the Vuelta a Espana at Tomares in Andalusia on Tuesday.
Aiming for a fourth consecutive Vuelta win
Roglic launched an attack on the flat stage
hoping to pick up bonus seconds to close the gap on race leader Remco Evenepoel
less than 3km out Evenepoel was hit by a puncture as Roglic looked set to eat into his 1min 34sec overall advantage.
But one hundred metres from the finish line Roglic swerved and fell hard
with his left knee and hand covered in blood
Evenepoel suffered a stressful few minutes awaiting a decision on timing and expressed relief as Roglic gained only eight seconds.
"I hope Primoz can carry on," said the Belgian Vuelta rookie
"I knew he would try and I'm sad for him." The 22-year-old enjoyed a lead of almost three minutes at one point earlier in the race
but Roglic took back time on two mountain stages over the weekend
Pedersen's win extends his large advantage in the race for the sprint green jersey on a day when the peloton raced at slower than 40kph on a sweltering day in southern Spain.
Pedersen also expressed concern for Roglic after seeing him stricken on the road just behind the finish line.
"I wanted to go to him here and I saw he was with destroyed clothing," he said
I hope it isn't too bad so he can continue competing for the victory of the Vuelta."
Stage 18 and 20 feature multiple mountains when Roglic and Enric Mas
Tuesday's stage ends with a 10km climb at a five percent gradient to an altitude of 2,512m
which creates the possibility of a mini shake-up
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By Hubert Walker for CoinWeek …
construction workers in the town of Tomares
a suburb of the southern Spanish city of Seville
discovered a hoard of almost 1,323 pounds (600 kg) of ancient Roman coins
workers were performing routine work on water pipes near Zaudín Park in Tomares when they noticed “irregular terrain” in one of the ditches they had excavated
At a depth of about one meter (slightly more than one yard)
the workers uncovered 19 amphorae – clay vessels used to carry or store grain
olive oil and a wide variety of other products – of a small type that was specifically used to store treasure
The vessels–10 of which were intact–were brimming with coins
a spokesman for the Andalusian Department of Culture said that the coins and their containers were “deliberately concealed underground with a few bricks and a ceramic filter”
Much like other nations rich in cultural and historical artifacts
Spanish authorities follow a protocol when such a discovery is made
and archaeologists assisted by the Andalusian government began to investigate and remove the amphorae from the site
The Archaeological Museum of Seville (Museo Arqueológico de Sevilla) is now in charge of the find
The Romans maintained a presence in Spain and the Iberian Peninsula for approximately 600 years
from the beginning of the Second Punic War in 218 BCE to the early fifth century CE
when a Germanic tribe known as the Visigoths succeeded in forcing a Roman withdrawal
the country of Spain gets its name from the Roman province of Hispania
The coins recovered last week–unusually homogenous in type for such a large find–date to the late third and early fourth centuries CE
Most (but not all) feature the emperors Maximian (ruled 286-305) and Constantine I (“the Great”; ruled 306-337) on the obverse
Each emperor’s coinage would have found its way to the Iberian provinces for different reasons
Maximian led Roman expeditionary forces into Spain against North African raiders between 296 and 298 but later retired to Massalia (modern-day Marseilles) in Gaul
where he died under suspicious circumstances in 310; Constantine reunited the Eastern and Western portions of the Empire after a period of rebellion
A variety of images of a mostly allegorical nature grace the coins’ reverses
The money is believed to have been intended either to pay soldiers and civil servants or to pay imperial taxes
The coins–almost all of them covered in a green
coppery patina–are in exceptional condition considering their age
The lack of wear leads experts to conclude that they were freshly minted and had yet to enter circulation
They were most likely minted in the eastern part of the Empire (in Greece
The majority of the coins are made of bronze
head of the Archaeological Museum in Seville
said that the find is “unique for Spain” and possibly the world
she has consulted with colleagues from institutions in Britain
who all emphasize the importance of the find for the academic study of the historical period under consideration
The museum’s Cultural Department says that no coins like the ones recovered last week already reside in their collection
Once the site investigation is complete and the coins have been processed
they will go on display in a permanent exhibit
Navarro would not give a more precise estimate
she was willing to state that the “priceless” treasure was worth at least “several million euros”
The exact number of coins has yet to be counted
http://www.abc.net.au/news/2016-04-29/roman-coin-cache-found-in-southern-spain/7369272
http://www.wsoctv.com/news/spain-park-workers-hit-on-huge-roman-coin-trove-by-accident/248506046
http://www.smithsonianmag.com/smart-news/spanish-ditch-diggers-unearth-1300-pounds-roman-coins-180958958/?no-ist
http://www.thelocal.es/20160428/building-work-unearths-600kg-of-roman-coins-in-spain
https://www.washingtonpost.com/news/morning-mix/wp/2016/04/29/construction-workers-in-spain-unearth-huge-trove-of-ancient-roman-coins/
http://elpais.com/elpais/2016/04/28/inenglish/1461850815_152135.html
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Image courtesy of Consejeria Cultura de la Junta de Andalucia
You never know when an everyday situation can turn historic
Such an event occurred in April in Tomares
Spain — a small town about five miles from Seville — when a team of construction workers installing electricity in a park unearthed an incredibly large haul of Roman coins
More than 50,000 coins were found in 19 jug-like vessels called amphoras
The actual weight of the haul was over 1,300 pounds (590 kilograms)
The workers halted their project when they realized what they had come across
It is believed that the machines used during the construction caused some of the breakage among the 10 shattered amphoras
but feature a small percentage of silver — less than 4 percent
in very good condition of conservation,” Ana Navarro
director of the Museo Arqueológico de Sevilla
When were the coins stashed away underground
“We have been able to read for sure inscriptions for Diocletianus
Maximianus and Maxentius; almost certainly for Constantius I and probably for Severus II
we could date this hoard to Tetrarchic times
a political system established by Diocletian [in] 293 to govern the vast Roman Empire that [lasted] until [the early third century] … when Constantine I defeated Majentius at the battle of the Milvian Bridge.”
These bronze coins were of the follis denomination
they appear to have a higher silver content than they actually do
and still gives a shinier look from certain angles
There’s still plenty to learn about the history behind these coins
What we do know is that this was a unique time of Rome’s rule
The Tetrarchy period saw four men rule with equal amounts of power
The thought behind this method was that the government would be able to handle issues from all corners of the empire without a ton of strain on one ruler
During this era, millions of coins were struck, under the names of 15 different people. Coins like the ones found in Tomares are readily available. They feature simple art, and are neatly struck. Most collectors liken them to a fine wine of sorts; they’re an acquired taste.
Navarro said that “only hypothesis and mere conjectures” can be offered as to the reason for the hoard
An “in-depth archaeological and numismatic study” will hopefully turn up more info
World Coins
Roglic attacks but crashes as Evenepoel punctures in final 3km
Behind, red jersey Remco Evenepoel (QuickStep-AlphaVinyl) suffered a puncture
meaning that he would be handed the same time as the main peloton when the commissaires reviewed the finish
Roglič led the five-man move all the way through the finale in Tomares
dragging them into the finishing straight with eight seconds in hand on the bunch
what looked like a successful day’s work for Roglič took on a different guise in the closing metres
when he crashed heavily after a touch of wheels with Wright
but he sat at the roadside in some distress after the finish
He was still there when Evenepoel came home almost three minutes later following his puncture
and the youngster went to check on Roglic before making his way to the podium
After a wait, the commissaires confirmed that Evenepoel had been awarded the same time as the peloton, meaning that he limited his losses on Roglic to eight seconds. In the overall Vuelta standings
“I wasn't in the best position because we did a recon of the final yesterday
in the last 4 or 5km so I lost some positions and I wanted to move up on a steep bump
I felt I had a flat tyre,” Evenepoel said
“I'm happy that the 3km rule exists otherwise I would have lost a lot of time today
I heard that Primož crashed so I really hope that he's OK and that he can continue the race.”
was a resounding winner in the sprint for the stage
The Dane has all but secured the green jersey thanks to his second stage win of the race
even if the day will be remembered for the late drama involving Roglic
Pedersen had not anticipated Roglic’s move
“Ackermann was straight on his wheel
I hope it’s not too bad so he can keep contending for the victory of the Vuelta.”
After the final rest day of the race, the Vuelta caravan assembled on the left bank of the Guadalquivir River for the start of stage 16 in the sherry-producing town of Sanlúcar de Barrameda. Maxim Van Gils (Lotto Soudal) was absent after testing positive for COVID-19 on Monday
while Esteban Chaves (EF Education-EasyPost) also withdrew before the start
but the rest of the 142 riders in the peloton were given a clean bill of health to continue in the race
Not many riders were much inclined to race
in the opening kilometres of a long and largely flat stage at this juncture in the Vuelta
Ander Okamika (Burgos-BH) and Luis Angel Maté (Euskaltel-Euskadi) attacked more or less as soon as the flag was dropped outside of Sanlúcar and they were given plenty of early leeway by the bunch
They quickly built a lead of four minutes before Cofidis and Trek-Segafredo set about policing the head of the peloton on behalf of Coquard and Pedersen
There was precious little change in that status for most of the long
where the only statistical interest was provided by Maté
who has pledged to plant a tree for every kilometre he spends off the front on this Vuelta
The break’s lead dropped to a minute or so by the time they reached the intermediate sprint in Alcala del Río with 28km to go
where Pedersen cruised through in third place to add another 15 points to his advantage in the green jersey standings
Okamika and Maté’s day-long adventure came to an end with 14km or so remaining
just as the terrain grew a little hillier on the approach to Tomares
Evenepoel’s QuickStep-AlphaVinyl squad positioned the red jersey towards the front from there on
with Ineos Grenadiers and Jumbo-Visma also moving up
The pace on the short unclassified ascent with 12km to go was brisk but not intense enough to burn off the fast men, though Kaden Groves (BikeExchange-Jayco) saw his hopes of victory torpedoed when he punctured over the other side
The stage took on altogether different guise inside the final 3km
The combination of that surprise effort and Evenepoel’s puncture seemed to be tilting the balance of this race back in Roglic’s favour
but the picture is muddled after his crash in the finishing straight
who had led the break into the closing metres
was drifting back when he appeared to make contact with Fred Wright
I was blocked by Primoz and I think that’s what caused the crash,” Wright said
“I think it was just a racing incident
I was coming out and around and he was coming backwards
Results powered by FirstCycling
Doctors recommend against staring directly at the sun
but the latest news in solar power may be worth a look
While costs associated with solar power are declining
growing government and private sector investment is helping manufacturing scale up and contribute to technological breakthroughs
Those successes are driving more investment and more research
the cost of electricity from solar has dropped by 87% and the cost of battery storage has dropped by 85%
Prices today are already lower than two-year-old predictions for 2030
are responding to this growing affordability
Thurston County’s senior program manager for climate mitigation
was optimistic about integrating solar capacity into county property
Panels have already been installed at the county’s public works facility and the county is considering other potential solar projects
“There are a lot of opportunities for how a local government can use its own space — including the land and rooftops we own and control — to maximize the benefits of clean
Those benefits go beyond reduced carbon emissions
Embracing solar power can bring new jobs to a community
lower residents’ energy bills and offer greater energy security by diversifying power sources
Department of Energy SolSmart program offers support to counties exploring solar power
SolSmart offers no-cost technical assistance to reduce costs and barriers for solar installations for local governments
Their training and resources are available to all communities whether they have experience with solar power or not
counties are learning how to reduce non-hardware “soft costs,” which can account for two-thirds of the costs of going solar
Their expert guidance helps counties effectively streamline processes
cut red tape and reduce installation delays and expenses
Meeting targets for cost-reduction standards can see a community designated “bronze
gold or platinum” which pertains to each community’s level of solar commitment
SolSmart has already designated 506 communities
achieving a silver designation earlier this year
and Harvey attributed guidance and support from SolSmart for that achievement
SolSmart’s support in setting and achieving goals
built up internal knowledge and confidence
building momentum for the county’s next steps
“[SolSmart] really does make it easy,” Harvey noted
They have developed the program to be clear and prescriptive in telling you what steps to do
but also open enough that if you have unique stories to tell or unique situations in your jurisdiction
Sharing information within the county and across jurisdictions has been a key to Thurston County’s success.
“One of the [SolSmart] requirements to achieve designation is to develop a solar landing page on your website,” Harvey shared
it’s very easy to share information such as state laws
Thurston County and three of its cities — Olympia
Tumwater and Lacey — collaborated to produce a multijurisdictional climate mitigation plan
avoiding duplication of effort and prioritizing proven cost- and time-saving measures
Two of those cities are themselves SolSmart designated
Olympia receiving Gold in 2022 and Tumwater Silver in 2023
For help getting started with solar power, contact NACo’s Resilient Economies and Communities team at SolSmart@naco.org.
SolSmart is a national program that helps cities
counties and regional organizations become solar energy ready
Communities rose all over the country to help build modern America
those places became home for the people who made that work possible
In the modest Sevillian suburb of Tomares, a three-year-old Juan Larios decides he wants to play football against the wishes, initially at least
It does not take long for him to become utterly engrossed
Larios begins setting up a makeshift goal inside the family home
he would see his older cousins already playing for the local club
He soon wanted to go with them to practice
Despite his tiny frame — he is only 5ft 5in (165cm) now — Larios started out as a goalkeeper
of his larger-than-life character from an early age
He would dive around with unrelenting enthusiasm
Even if his love of football refused to dim
Especially after banging his head on a post
countryman Jordi Alba was beginning to emerge as Europe’s best in that position
winning Champions Leagues and European Championships
Generation Z footballers who moved to England as teenagers in the summer of 2020
The Spaniard’s switch to left-back was transformative
Larios was scouted and invited to train with Sevilla’s academy at the age of seven
He would stay at his hometown club for four years before the giants of Barcelona spread their net east
The thought of moving 10 hours away from the family home and more than 950 kilometres admittedly came with trepidation
the overriding feeling was that he would adapt
Larios was and still is an extreme extrovert
popular and talkative with those who come into conversation with him
there were few doubts he could make new friends and flourish in the eminent La Masia academy
He lived in a dormitory on his own within La Masia
despite the grounds housing around 60 players
remaining at left-back but developing the technical and tactical aptitude required to play at the highest level
He was courted by Spain’s youth teams at under-15 level before stepping up to their under-16 and under-19 sides
His understanding of the position tallied with a maturity beyond his years
“It (moving away from home aged seven) leads to a very quickly grown person,” Southampton manager Ralph Hasenhuttl tells The Athletic. “He has a character that you can feel there are a lot of things happening in his life since being here and in a positive way
This is what you can feel when you talk to him
They beat competition from Manchester rivals
City signed Larios for a fee worth in the region of £400,000 ($450,920)
The deal to bring Larios to England was negotiated through intermediaries and finally completed in September 2020
following protracted discussions throughout the transfer window
His family recognised his determination and were reluctant to stand in his way
No aspect of the move was thought to have fazed Larios — even in the isolated circumstances of relocating to a different country during the restrictive times of COVID-19
he was used to spending long stretches on his own and away from family
Larios initially joined City’s under-18s before moving to their Elite Development Squad (EDS) at the start of the 2021-22 campaign
He maintains a good relationship with Pep Guardiola and credits him for playing a key role in his development
Larios transitioned to right-back on occasions
including the game against Mansfield Town in the Papa John’s Trophy two days before joining Southampton
as well as his ability to counteract his physical disadvantage — such as his height — through increased aggression and confidence
will only be positive for his future career
possibly more than any other manager in modern football
has shaped the role of a modern full-back and how they are perceived
The City manager has given the position increased responsibility
to where the onus is on a full-back to influence games from an attacking standpoint
They are tasked with taking up inverted positions in midfield and performing within rotational patterns of play
Larios can only have benefitted from such principles
Larios spoke to Lavia before deciding to sign
who has established himself as the poster boy of Southampton’s distinctive youth model
expressed the positives of making the move
The teenager subsequently signed a five-year deal on deadline day along with City team-mate Samuel Edozie
They were Southampton’s third and fourth summer signings from the Etihad
with Edozie spending three seasons in Manchester
was one of the men responsible for bringing the winger to the club
having first started tracking him at the age of 12
The combined fee for Larios and Edozie was £16million
as City inserted various contingents such as a buy-back clause
sell-on clause and matching rights — where they can match any offer Southampton receive for either player
Larios has acclimatised well to life on the south coast
who was in England in the early weeks after signing to help his son get settled
to frequently commute between the family home in Seville and Southampton
Dani has been married to Larios’ mother for most of her son’s life
so he has been a key part of his childhood
⚡️ @juan_larios7 pic.twitter.com/ushomTfpeY
— Southampton FC (@SouthamptonFC) September 7, 2022
Dani was in attendance for Larios’ Premier League debut against Aston Villa
where there was an element of surprise at seeing him come on at half-time and play the second period
such as his fondness of the British weather
Though comparisons between Seville and Southampton are scarce
the two cities are similar in where they are situated in their countries
Both are on the coastline and southernly — Larios can continue to enjoy living near the sea and a general sense of tranquillity
The benefits of moving to Southampton are thought to have outweighed a notoriously busy Manchester city centre
where his outgoing but level-headed personality can easily steer clear of distraction
Larios returns to the club he left a little more than a month ago
Both Southampton and City continue to think highly of him
with his current boss likening the 18-year-old to illustrious company
“He reminds me of a very famous player in Germany,” says Hasenhuttl
“I played with him when he was 18 or 19 in the second team of Bayern Munich — it was Philipp Lahm
He (Larios) is a little bit similar to him
He is very clear in his mind and very clear in what he wants to do and what he wants to achieve
This is what you need in modern football.”
(Top photo: Matt Watson/Southampton FC via Getty Images)
Jacob is a football reporter covering Aston Villa for The Athletic. Previously, he followed Southampton FC for The Athletic after spending three years writing about south coast football, working as a sports journalist for Reach PLC. In 2021, he was awarded the Football Writers' Association Student Football Writer of the Year. Follow Jacob on Twitter @J_Tanswell
Construction workers working on water pipes in Seville stumble upon ‘unique’ collection of bronze coins said to be worth millions of euros
Construction workers have found 600kg (1,300lb) of ancient Roman coins while carrying out routine work on water pipes in southern Spain, local officials have said
“It is a unique collection and there are very few similar cases,” Ana Navarro, head of Seville’s archeology museum, which is looking after the find, told a news conference.
Dating back to the late third and early fourth centuries, the bronze coins were found on Wednesday inside 19 Roman amphoras, a type of jar, in the town of Tomares near Seville.
Navarro declined to give a precise estimate for the value of the haul, saying only that the coins were worth “certainly several million euros”.
Read moreThe coins are stamped with the inscriptions of emperors Maximian and Constantine
and they appeared not to have been in circulation as they show little evidence of wear and tear
It is thought they were intended to pay the army or civil servants
“The majority were newly minted and some of them probably were bathed in silver
because the value they really have is historical and you can’t calculate that.”
Local officials have suspended the work on the water pipes and plan to carry out an archaeological excavation on the site
The Romans conquered the Iberian Peninsula in 218 BC
'Bizarre' Roglič crash leaves Vuelta future in question
Giro d’Italia and Vuelta a España.Get the latest with our sport podcasts on your favourite podcast apps.Watch on SBS SportSport News
Fishback was nominated for “Outstanding Performance In A New Series,” following her depiction of her character Dre in “Swarm.” The dress she wore to the awards show didn’t disappoint
The train on the number cascaded perfectly and didn’t overpower the rest of the look
The neckline featured one-shoulder detailing
exposing her shoulder tattoo and part of her decolletage
The rest of the dress appears as if it was reconstructed with panels of black glistening fabric pieced together by diamond-clad ringlets
Her hair was in an elevated bun and wispy bangs on the sides
For jewelry Tomares opted for a dainty necklace on her neck and on her feet
Last night’s Givenchy look reminds us that Fishback is a red carpet darling and one to watch when it comes to fashion
her role in “Swarm” was still one of the year’s most impressive television performances
Primeras imágenes del hallazgo de monedas romanas de Tomares en el #MuseoArqueologico de Sevilla pic.twitter.com/5aK5fovNjj
a Spanish construction crew that was installing electricity in a park in Tomares — a town in the province of Seville — made an incredible discovery.
CNN reports that while digging
the crew banged into a collection of ancient Roman bronze coins that date back to the third century.
Tens of thousands of coins were found in 19 amphoras
According to the Spanish newspaper El Pais
the initial hypothesis is that these coins were stashed away to pay taxes or army levies.
There's no initial information regarding the overall value of this hoard.
Scottish novelist and poet Nan Shepherd and scientist Mary Somerville will grace two new Scottish notes from the Royal Bank of Scotland starting in 2017.
"The bank says this is the first time the two notes will feature women," writes Arthur L
"The theme for both notes is 'the Fabric of Nature.' They will be printed on De La Rue’s Safeguard polymer substrate and will contain a variety of security features that De La Rue says will make them hard to counterfeit but easy to authenticate."
The Professional Numismatists Guild made a public service announcement recently
warning the public about thecounterfeits that are running rampant right now.
If you're a serious collector, you'll want to read this
Kitco.com lists the following prices per ounce Monday at 9:05 a.m
Check out three interesting stories from the last couple of days:
El flamenco It is made up of diverse geographies
We cannot understand our culture without that uniqueness that comes from the land
Some of which have a very marked distinctive feature
From the San Miguel and Santiago neighborhoods of Jerez de la Frontera come Jesus Mendez y Pepe del Morao Andevalean style Peña flamenca Smuggling
Almost 250 kilometres crossed from south to north of western Andalusia
and in between a host of different events with marked personalities
I have just returned from Paymogo and I want to tell you about the good taste that both artists have left in our mouths
It was clear that Méndez and Morao had come to put their hearts into it
and from the first note they have established a special communion with the audience
Pepe del Morao played the sonanta por soleá
so that Jesús Méndez could lead us with his usual elegance to the enjoyment of the cante great
What a pain in the ass my mother / when am I going to have a mother / like the one I had
the Jerez native finished his performance with soleá
Rescuing the airs of The Twin y Chacon He gives us two malagueñas
with no more decoration than what he himself cante requires
The powerful voice of Jesus is tempered and envelops us to pinch us in one of the best moments of the night
Perfectly escorted by a guitarist who oxygenates and carries the singer on his shoulders until delivering the right melodic sounds so that he finds the space and executes the cante in a remarkable way
Tientos and tangos bring us to the close of the first part of the recital
The siguiriya that Jesús has given us is very good
The siguiriya sounds of Jerez de la Frontera appeared in his throat and the siguiriya became even richer on Pepe's strings
They are feeling the stones My fatigues I wear them day and night
A magical heartbeat that has moved us and made us feel
Just what should be demanded of cante by siguiriyas
«Pepe del Morao played the sonanta por soleá
so that Jesús Méndez could take us with his usual elegance to the enjoyment of the cante "big
my mother / when will I have a mother / like the one I had?'"
There is no room for the slightest misstep
The enormous voice of Jesus and the accompaniment of Pepe take us to the land of wine and horses and they even put the rhythm into our skin
The night will be rounded off by a range of fandangos
ending with an audience grateful for the dedication of a singer who
as he himself warned at the beginning of the night
It is difficult to find recitals by relevant artists
That is why we must highlight when professionals of this stature put the spotlight on the role of flamenco associations
As the artist has repeatedly said during his performance
We must also acknowledge when artists of this stature visit our entities
not leaving even an iota of professionalism off the stage
Recital by Jesus Mendez and Pepe del Morao Peña Flamenca Smuggling
2025 Cante: Jesus Mendez Touch: Pepe del Morao
I was born in Flamenco at a table of cabales of the Peña Flamenca from Huelva
I do so from the heart and looking at the people
Quick-Step Floors have won 15 Grand Tour stages this season
a performance only five other teams have attained throughout history
Matteo Trentin and Quick-Step Floors continued their incredible dominance at the Vuelta a España
nabbing a fifth victory in 13 days and thus matching the fantastic achievements set earlier this year at the Giro d'Italia and the Tour de France
After winning in Tarragona and Alhama de Murcia
a small municipality located just a few kilometers from Sevilla
Quick-Step Floors were again at the head of proceedings in the long and hot stage 13
which took the peloton from Coin to Tomares (198.4 kilometers)
but Belgian powerhouse Tim Declercq did once again a tremendous job at the front
keeping the quintet on a leash and making sure the gap didn't go north of 3:30
Declercq – a Grand Tour debutant – rode a relentless tempo at the front
and helped at times by Eros Capecchi and neo-pro Enric Mas
successfully nullified the breakaway inside the final ten kilometers
Former red jersey Yves Lampaert then moved to the front and softened the peloton
who stretched out the pack before the final three kilometers
which included a small but leg-sapping uphill drag
The penultimate Quick-Step Floors rider in the lead-out train was Bob Jungels
and the Giro d'Italia maglia bianca really did some huge damage in the pack
leaving around 20 riders in the main group
stage 8 winner Julian Alaphilippe took over the same role he had on stage ten
shutting down a late attack and positioning Matteo Trentin in the technical run-in
who unleashed a ferocious sprint with 200 meters to go
beating Gianni Moscon (Team Sky) and Soren Kragh Andersen (Team Sunweb) and adorning his palmares with another Grand Tour stage victory
it wasn't a finish which suited me; what was on the road was different and harder than what we had in the roadbook
The guys were again incredible today and rode an amazing race
pushing a really hard tempo in the closing kilometers and guiding me in the final; when you have such a marvelous team by your side
you have to win and I'm happy for having finished off the job today"
who extended his cushion at the top of the points classification after his success in the Andalusian town
Trentin – the first Italian in ten years to take at least three stage victories at a single Vuelta a España edition – also referred to Quick-Step Floors historical run this year in the Grand Tours: "I came to this race with confidence
but I wasn't expecting such an incredible string of victories
You don't see every day a team win 15 Grand Tour stages in a season and what we have done so far this year is something which will stand forever
What is even sweeter is that the race is far from being over and we'll have more opportunities to notch up other strong results."
David De La Cruz continues to be the highest-place Spaniard in the general classification of the season's final Grand Tour
who posted a podium and two-10 finishes so far since the start in Nimes
is fifth overall and will go into Saturday's tough stage to Sierra de la Pandera ready for what promises to be another spectacular and exciting fight in the mountains
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the dance master passed away at the age of 82 Eduardo Serrano
he earned his stage name for his dark complexion and small size
He left an indelible mark of his mastery in the thousands of hours of teaching at the legendary Madrid school on Calle Love of God
today on the upper floors of the Antón Martín Market
run by his close friend and companion of many years Joaquin Sanjuan
She began to take her first steps in dance at the Madrid academy of Antonio Marin
where another large one that disappeared a few days ago was also formed
the chungaBut her career took off when she joined the Ballet of the great teacher Pilar Lopez with fourteen years!
Antonio Gades and Farruco (that's nothing)
Eduardo always considered the sister of the little argentinian as his teacher
who according to him taught him everything that made him become a great dancer flamencoWith it he won the award for best dancer of the season in 1959 at the Theatre of Nations in Paris
I had the good fortune to meet him and chat with him on several occasions
Patas HouseBut the day that I was a sworn judge of the Cordoba Competition
Jose Manuel Gamboa and server in the The Blason Restaurant from Cordoba (El Sablon
during which the two teachers told each other anecdotes about Doña Pilar’s ballet
as they referred to their teacher (she referred to them as “my children”)
Güito boasted of arriving at the theatre five minutes before the performance while Mario needed to warm up for an hour and a half
to which the Cordoban teacher replied sarcastically: “Come on
you’ve been doing the same soleá for thirty years.” To which Eduardo replied: “I’ve changed some steps.” Hahaha
I still crack up every time I remember that unforgettable moment
Between 1971 and 1975 he formed the Madrid Trio along with Mario Maya and Carmen Mora. That remains for history. buleria por soleá that Mario and he dance close to each other
Gades incorporated him into the cast of the National Ballet when he created it in 1978
hence Güito appears in the film Saura Blood Wedding
His most emblematic choreography that has gone down in history is none other than his very personal dance solea with music Emilio de Diego
the guitarist with more than twenty years of experience alongside Antonio Gades
The slowness with which he carries the air has forever marked a way of measuring that some even call “soleá de Madrid”
The illustration for this brief obituary consists of sketches drawn by the versatile French artist Jean Cocteau When Eduardo was part of the company of Manolo Caracol in Malaga
and which have been preserved thanks to the fact that Güito's mother put them in a safe place
The dance flamenco of man loses one of its most distinguished figures, with him a glorious stage of dance closes, unrepeatable. Thanks to Gamboa today we can enjoy reading his life, which he masterfully captured in the book El Güito The head of the flamenco! Facts and deeds of the masterMay this true great of dance rest in peace
With a degree and a master's degree in musicology from the University of Vienna
he has given courses and seminars all over the world
he has been musical director of the Antonio Gades Company and president of its Foundation
In the nineties he was director of the Deutsche Grammophon label
Author of numerous educational and scientific books on flamenco
He is the author of the website www.flamencopolis.com
Record producer and professor at the Aula de Flamencology of the University of Cadiz
of the Master of the Higher School of Music of Catalonia and until September 2017 he was Professor of flamenco from the Conservatory of Music of Córdoba
He currently resides in his hometown where he continues his work as a teacher and lecturer
and not like those who proliferate who seem to have been electrocuted..
I feel grateful to have enjoyed the master
I recently acquired his biography written by Gamboa
The English translation of this tribute must have been produced by AI and left long unedited by human agency
AcademyUD Almería U19 'A' cannot drop points in race to top the table After setback against UD Tomares U19, the UDA Academy prospects host CD Vázquez Cultural this Sunday at the Francisco Pomedio ground (KO 12:30pm CEST)
SPAIN - SEPTEMBER 06: (L-R) Primoz Roglic of Slovenia (injured after being involved in a crash in the final sprint) and Mike Teunissen of Netherlands and Team Jumbo - Visma cross the finish line during the 77th Tour of Spain 2022
Stage 16 a 189,4km stage from Sanlúcar de Barrameda to Tomares / #LaVuelta22 / #WorldTour / on September 06
(Photo by Justin Setterfield/Getty Images) Credit: Justin Setterfield/Getty Images
Vuelta 'sh*t' without Roglič but Mas vows to take fight to Evenepoel
Presentation of the IX Art Biennial Flamenco from Malaga
The President of the Provincial Council of Malaga, Francis Salad, presented on the morning of Wednesday, April 2, the IX Art Biennial Flamenco from Malaga
which takes place from May 27 to August 2 in 26 municipalities in the province
"which demonstrates the economic effort of the Provincial Council to bring the flamenco to the greatest number of citizens,” he stressed
Salado was accompanied by the director of the Andalusian Institute of Flamenco, Christopher Ortega; the Vice President and Deputy for Culture, Manuel Lopez Mestanza; the territorial delegate of the Ministry of Culture and Sport, Carlos Garcia; and several participating artists, such as Luisa Palicio, Duquende, Francisco Bonela, Isabel Guerrero, Carmen Camacho, and Rubén Lara.
The graphic design of the Biennial has been entrusted to the Malaga company fussy, which has delved into the history of old festivals to rescue that typeface, now in disuse, to highlight it in the posters and graphic material for this ninth edition.
The program is broad and varied, combining youth and experience. It is estimated that nearly two hundred artists will be participating in the Biennial, including Manuela Carrasco, Farruquito, Aurora Vargas, Duquende, Pedro El Granaíno, Antonio Reyes, Jesús Méndez, José de la Tomasa, Luisa Palicio, La Lupi, Bonela Hijo, and Pastora Galván, among a long list of artists.
The President of the Provincial Council highlighted the four major shows that make up the main focus of the program. The Biennial will open on May 27 at the Cervantes Theater with the world premiere of The Maharani, in charge of the company of Luisa Palicio. It features guest artists such as Passion Vega, La Macanita, Carrete, Chato de Málaga and El RemacheAt this opening gala, the Biennial award will be given to the flamencologist Gonzalo Rojo for his long history in favor of flamenco.
And the Biennial will close on August 2nd in the Rincón de la Victoria auditorium with a show of its own production, I am a gypsy, which takes a tour of the cantebest known of Camarón de la IslaThe cast is made up of Duquende y Peter the Granain, cante, and Farruquito, to the dance, next to the Malaga Provincial Symphony OrchestraAll arrangements and musical direction are by the composer. Jesus Bola.
On July 20, in the Mijas auditorium, the Ballet Flamenco AndalusiaDirected by Patricia guerrero, will present his new production, Blessed land, whose characteristics have been explained by Cristóbal Ortega.
Although Manuela Carrasco She has paced her performances, she wanted to be at the Málaga Biennial for another year and has prepared a premiere, surrounded by excellent artists. Dancing to Manuela will meet on July 26 in Ojén Pastora Galvan, Gema Moneo, Zamara Carrasco, Manuela Carrasco daughter and Saray de los Reyes.
On August 1, the new Coín auditorium will host a series of top artists with their own unique identity. Aurora Vargas, Antonio Reyes, Jesús Méndez and the bailaora Manuel Carpio They will carry the purity and gypsy spirit of the flamenco.
On June 28, the Biennial will bring a show to Alcazabilla Street in the traditional format of flamenco which will be played by Jose de la Tomasa, Vicente Soto 'Deafness', Juana of the Pipe and Concha Vargas.
Francisco Salado also highlighted the debuts of the Malaga team Francisco Vinuesa, La Lupi, Ana Almagro, Rubén Lara and Luisa ChicanoGuest artists in various shows include Rocío Molina, Pasión Vega, Carrete, La Macanita, Manuel Liñán, Alfonso Losa, Chato de Málaga, and El Remache.
Ana Fargas and Paco Javier Jimeno will be with Fallen leaves in Álora and Isabel guerrero and Hairdresser in Almáchar. For her part, the flamenco dancer Sandra Cisneros will give life to María Zambrano with Mary of my entrails in Alhaurín el Grande, while the Jerez family of The Mijita will be held at the Ronda Wine Centre.
As a preamble to the Biennial, it will take place in the church of the Divina Pastora From the Capuchinos neighborhood on May 25, a flamenco mass with the canteliturgical s through the palos of the flamenco in the voice of Antonia contreras and the touch of Juan Ramon CaroThe mass will be broadcast live on Canal Sur. The day before, on Saturday, May 24, there will be a cajoneada in the Plaza de la Merced with 70 cajons played by children from Cruz Verde and Lagunillas.
Likewise, the Biennial resumes the cycle Flamenco tall, from the AC Málaga Palacio Hotel, with five recitals, and collaborates with the X International Camp of Flamenco and Dance Spain for Young Values, which will take place at the CEULAJ in Mollina, as well as with the masterclasses of the International Seminar of Flamenco 'City of Malaga', in collaboration with the School of Flamenco Andalusia.
On the other hand, a documentary series will be held on the five Tuesdays of July at the María Victoria Atencia Provincial Cultural Center. The following will be screened: Don Quixote in New York, with Reel; Fandango, Ana Delgado. Memories of India, Fosforito, a story of flamenco y Zambra.
The Provincial Council Art Museum (MAD) in Antequera will host joint exhibitions of two great artists, David Vaamonde in sculpture and Javier Caró in photography. These exhibitions have been provided by the Andalusian Institute of Flamenco, within the collaboration agreement. And Benalauría opens the doors to the photographs of Pepe Ponce y Pablo Blanes dedicated to flamenco women.
“Beyond this extensive program, I want to highlight the Biennial's continued success, having been interrupted for two editions, specifically in 2009 and 2011. We have consolidated and continued it, which is the best of news,” concluded Francisco Salado.
Cristóbal García also participated in the presentation, highlighting the IAF's collaboration with the Art Biennial. Flamenco from Málaga, and Luisa Palicio, who has shown her joy at having the enormous responsibility of inaugurating the Biennial of her land with her own show.
Family photo of the Director General of Culture and Creative Industries
together with several artists from this edition
The figure of the brilliant and innovative guitarist You know presides over the second edition of the Flamenco Guitar Festival of the Community of Madrid
which is held in Teatros del Canal from April 24 to 27
Manuel valencia y David of Arahal are the stars of the four galas that make up the festival
which was presented on Tuesday 4 March by the Director General of Culture and Creative Industries
will be completed with three parallel days that include a round table about Sabicas
two presentations on aspects of the legacy of this guitar master born in Pamplona in 1912 and died in New York in 1990
According to its director Antonio Benamargo
the Flamenco Guitar Festival has come to fulfil the desire of artists flamencos in general and of guitarists in particular in a city whose fondness for flamenco sonanta is outstanding
Both the artistic results and ticket sales exceeded all expectations in its first edition held in 2024
In its second date, Teatros del Canal once again becomes the stage for major concerts, which will be opened by the Sevillian Paco Jarana at the first gala of the festival on April 24
winner of the Giraldillo al toque at the 2006 Seville Biennial
His career is closely linked to dance accompaniment and also to cante
Since 1998 he has composed and directed the music for Eva Yerbabuena's shows
the guitarist will have as guests a singer or singer and a dancer or dancer
Second Falcon y Eva Yerbabuenarespectively
«The Flamenco Guitar Festival has come to fulfill
according to its director Antonio Benamargo
the desire of the artists flamenco"The festival is a great success for flamenco guitarists in general and for guitarists in particular in a city with an outstanding fondness for flamenco guitars
Both the artistic results and ticket sales exceeded all expectations in its first edition held in 2024"
The second gala will feature the also Sevillian Dani de Moron
Giraldillo at the Seville Biennial in 2012
Dani is one of the guitarists flamencos most awarded of the last decades
which definitely took off after the maestro Paco de Lucía noticed his virtuoso qualities
Constant in his evolution as an artist are the restlessness
the encounter and transfer with other sounds and instruments typical of music beyond the flamenco
His recordings include the albums U-turn (2012) The sound of my freedom (2015) 21 (2018) and Believe to see
In 2022 he presented at the Nimes Festival Carte blanche
At his Guitar Festival concert he will sing The Tremendous and will dance Patricia guerrero
The guitar of Manuel of Valencia will ring on Saturday 26th
with the cante from the Sevillian Hope Fernandez and the dance of the Granadan Manuel Linan
He grew up in Valencia under the guidance of his most trusted guitar instructor
2014 marked a turning point in his artistic career
when he was awarded the Giraldillo Revelación prize at the Seville Biennial
Two years later his first album as a concert artist was released
an audiovisual trilogy in which he addresses his own musical and artistic transformation
bringing into play the different disciplines of flamenco guitar
such as accompaniment to cante and to dance and concert guitar
Black earth is his most recent audiovisual work
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The 30th edition of the International Flamenco Fashion Week
with a 7 percent increase in visitors compared to the previous year: 60.000 people
The largest international showcase of flamenco fashion has attracted visitors from all over the world. Andalusian provinces
with the arrival of 183 buses from different parts of the region
as well as visitors from other autonomous communities and various countries in Europe and Central America
The color palette ranges from shades sand up to the paprika, green hunting, saffron green and olive green, with browns particularly prominent. Navy blue and petrol blue are also present. In contrast, fuchsia, red, white and black have had a more discreet presence in this edition.
This year the highlights are: Custom fabrics with original prints, both geometric and floral. Also, gingham and stripes. The firms have opted for fabrics with a great drape, such as knit and crepe. The former provides elasticity, while the latter does not wrinkle or lose colour. Polka dots have evolved: from an orderly and perfect design to a more unstructured, irregular and smaller version.
«We have celebrated 30 years of promoting and revolutionising flamenco fashion. It has been a truly international week of flamenco fashion, marked by spectacular shows and activities that have fused culture and fashion, consolidating the growth of this industry, a key sector for Andalusia» (Raquel Revuelta)
In this edition, the event featured the Sevillian actress and director Paz Vega as maid of honor and the singer Pastora Soler as honorary ambassador, who also celebrates 30 years in music and performed the Andalusian anthem during the inauguration, which was attended by the mayor of Seville, Jose Luis Sanz. In addition, the iconic SIMOF model Mercedes Munoz She paraded in a train gown, designed exclusively to commemorate the 30th anniversary of the event.
The model Maria Jose Suarez, the influencers Margarita de Guzman (@invitadaideal), Claudia Ula Jimenez Revuelta and Javier Hierro and the designer Jose Perea have been the official influencers of this year. In addition, Perea made a suit live with more than fifty meters of fabric, provided by Flamentex. The piece has been another of the great tributes to the 30 years of SIMOF, combining tradition and modernity.
Singer Pastora Soler, the Italian model and presenter Antonia Dell'Atte, the influencer Rocio Osorno, the dancer Cecilia Gomez, The designer Elena Benarroch, the influencer Gloria Camilla, singer Rosario Mohedano and the singer Manu Tenorio, ambassadors of SIMOF 2025, They have received a statuette by the Jerez artist Cristóbal Donaire, Balcris.
The Association of Fashion Designers and Flamenco Crafts of Andalusia (Mof&Art) has recognized the great legacy of the designer Just Salao, coinciding with the 20th anniversary of the association.
La sevillana Lucia Ruiz Guerrero, 20 years old and from El Viso del Alcor (Seville), has been the winner of the Competition for New Flamenco Fashion Designers with your collection CoralesThe SIMOF 2025 revelation award has been awarded to Sara Pozo Moreno from Seville with Thalassa.
El Aromas Award The best model of SIMOF 2025 has been awarded to the model Cristina Lopez Japan and the Aromas Crea Award It has been for the designer from Granada Antonio Gutierrez.
In addition, the designer Sara Sanabria with your collection Bambola has won the SIMOF Designer Poster Competition, sponsored by Clínica Doctor Ortiz, valued at 1.000 euros. While the special mention, prize chosen by the public through social networks, was for Sara de Benitez for the poster of his collection So.
In it we not only see the musician playing with magnificent companies –Remedios Amaya, Farruquito, Israel Fernandez, La Tana…–, but also displaying his intimate wounds, especially a family episode that marked his childhood, and on which the film wants to act as a sort of exorcism.
“It all started when I went to a party, met Yerai, fell in love with him, and from there we started working,” says C. Tangana. “As an artist, I have always used my life. Here it is not about mine, and Yerai’s responsibility. During the shoot we depended on Yerai, on how he felt, where the story was, what hurts him, what he yearns for. I am fed up with myself, and in that sense this project has been very liberating, there was something of salvation for me in it.”
“I only had one red line,” adds the singer and newly minted filmmaker, “and that was that The film was supposed to make things better for Yerai's family., and not as a simple artistic game between him and me. We couldn't afford to make things worse. When my artistic blindness prevented me from seeing it, Yerai reminded me of it.”
«The poster and the images at the beginning and end of 'Yerai Cortés' Flamenco Guitar' represent the takeoff of a spaceship. It is a metaphor for the longing to connect with those heavens where the loved one who has lost lives. But it could also be read as the definitive propulsion towards stardom of an artist with a legitimate hunger for success»
Along with Cortés, his parents have a prominent role in the film, Miguel y MaríaThe guitarist says he wanted to reconnect with them after a few years of distance and disagreements. “In Madrid I lead a very different life to the one I led in Alicante, and I wanted my parents to know me, to know about me. To bring me up to date with them. But it has also helped me to get to know them better.”
Everything from the plans to the letters is calculated to elevate Yerai Cortés to the category of new icon, especially for the new generations of viewers. However, the musician stresses that “the protagonist of the film is not the guitarist, but the guitar and what I tell with it. The process has been amazing, a very nourishing learning process because of what everyone contributes,” he says. “I am flamenco, but in the film we wanted to tell a story.”
A quarter of a century of cultural journalism
Photo: Carlos Fernández - extampasflamencas.com
We live in a flamenco generation in which there are very few artists who stand out for being creators
when one goes to a concert-recital in which everything is new despite being half a century old
one leaves grateful and with the happy conscience of having lived special moments
You hear the same thing over and over again cante
which seem the same but are nothing like each other
the feeling of the value of the true contribution to the cante and the value of being and sounding like yourself
few bulerías are as personal as those that contributed Lole and Manuel Back in the seventies
giving a renewing twist to the concept of new flamenco and being pioneers in what a few years later would become an official trend
Today we only have the great Lole montoya to remember those songs that have left such a mark on the new generations and that have given so much color to this cante
is identical to the one she marked when she was touring with her husband Manuel
Lole Montoya celebrated Andalusia Day at the Peña Flamenca The Silversmith (Granada), in an intimate recital open to the public with the guitar of the young man Manuel Angel Rojas. Packed to the rafters, the performance was presented by the young woman Alba Peña, young member of the Board of Directors.
Rojas came out, taking his place as the singer's squire, who was received with a great ovation. Everything is colored opened the night. So, at first, we could think that the canteAn artist's most popular songs are often left for last, but in this case it is that Most of his works have been the soundtrack of several generations so the repertoire became a concatenation of cantes, almost all of them by bulerías and hit parade at the time.
«Lole's brilliant voice is still alive, although the strength of yesteryear has given way to a thread of sensitive sweetness that tempers the rhythm of the bulerías until it stops. That is why the singer almost speaks cante»
Lole's brilliant voice is still alive, although the strength of yesteryear has given way to a thread of sensitive sweetness that tempers the rhythm of the bulerías until it stops. That is why the singer almost speaks cante. So much so that Rojas sometimes had trouble closing the thirds. It is also true, and so it seemed, that there were hardly any previous rehearsals, since the closings of some cantes were independent.
To finish her performance, which was not particularly long in time, she wanted to use part of the repertoire that she learned in her childhood from her teachers, her mother Antonia La Negra. A long, intense, slow, personal bulería that returns to its origins, those in which the versatile Manuel gave his own light with his poetic lyrics that crossed the soul with just three verses and told a life story in such a short meter.
Lole Montoya's recital Peña Flamenca The Silversmith, Granada February 28th 2025 Cante: Lole Montoya Guitar: Manuel Angel Rojas Full capacity
Education inspector and doctor in flamenco
Critic flamenco and I International Research Award of Flamenco
Paula Comitre. 'Apres vous, madame.' Nîmes Festival 2024. Salle de l'Odeon. Photo: Nîmes Festival
The economic crisis first and then the pandemic have imposed a trend towards austere formats: if your proposal fits in a suitcase, fine. If instead of eight musicians you can get by with one, so much the better. But that does not necessarily make it easy for creators. On the contrary, it forces them to squeeze the most out of those few resources, to bet on more interesting stories and, ultimately, to get the best out of each one. After you, madam seems to respond to that requirement.
The argumentative pretext is none other than to remember Antonia Merce Argentina, and the moment when she settled in Paris, then the capital of the world. A spotlight reveals the back of the Sevillian dancer, her arms begin to move to the rhythm of Bass's keys, which throughout the production will be exploring different sounds by means of a game of magnets and adhesives on the piano strings. For example, the vibration of the castanet, invisible in Comitre's hand.
«Comitre develops a simply captivating dance discourse: barefoot or in heels, splendid in her feet as well as her arms, she maintains a frenetic dialogue with Orlando Bass's piano with moments of almost dizzying speed, but also with its calm passages»
As the light expands, we see a vertical surface of blood red color, with a viscous texture and shine, resembling a bloody fiber, perhaps an entrail. A part of it comes off like a train of dresses, which will surround Paula Comitre's waist throughout the show. The artifact also has the capacity to be inflated and deflated through a mechanism controlled by the dancer, which allows her to play with volumes before the eyes of the spectator.
Nîmes Festival 2024 Odeon Hall January 16, 2024 Dance: Paula Comitre Piano: Orlando Bass
Academy2-1: First win of the season in the bag for UD Almería U19 AThe UDA Academy prospects grabbed the three points in their home debut against Tomares UD
who made the match very complicated for them
AcademyUD Almería U19 A to go all out for victory on Matchday 2 The Academy Rojiblancos host Tomares UD at the Francisco Pomedio stadium at 12 noon on Sunday
UD Almería Under-19s 'A' seek to make up for the first defeat of the season in league opener against Córdoba CF U19 and have the opportunity to defeat Tomares UD
The youngsters will play at the Francisco Pomedio stadium
Both youth teams will go into the game level on points
none of them have been able to collect points in their first match of the campaign
Zeus Carmona's youth side showed that they had potential in their league opener
they were unable to score a goal and therefore
they have put in the graft in to be able to get the first points this term against rivals who last season were very close to being relegated
Although it is true that in their first match of this season they put in a good performance against Cádiz CF U19
so the UDA Academy boys will have to remain focused in the match to be able to overcome their next adversaries
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Three-time Vuelta a España champion Primoz Roglič made an audacious late attack that almost paid off with a substantial time gain on red jersey Remco Evenepoel
but he crashed within sight of the finish line in Tomares
paying a heavy price to take back only eight seconds
Green jersey Mads Pedersen joined Sam Bennett
Jay Vine and Richard Carapaz in the Brace of 2022 Vuelta a España Victories Club on Tuesday
cementing his points classification lead in the process
You can watch the 77th Vuelta a España at FloBikes
Tuesday’s fare was for the sprinters
as there were no classified climbs and only a couple of ripples near the end of 189.4 km
The third and final week of #LaVuelta22 gets underway with a stage for the sprinters, between Sanlucar de Barrameda and Tomares, over 189.4 kilometers. pic.twitter.com/Jtc07cUcgk
— Quick-Step Alpha Vinyl Team (@qst_alphavinyl) September 6, 2022
Fitting the pattern of the stages last week
bothered to go out in the breakaway on such an obvious sprinter’s day
Cofidis and Trek-Segafredo did most of the pace-making in the peloton
the intrepid Spanish duo sopped up with 14 km to go
With 2.6 km to go Roglič attacked on a little uphill rise
Pascal Ackermann was able to follow and as other riders were making their way over to the move
That was the Slovenian’s first bit of bad luck
Roglič crashed after a touch of wheels with 100 metres to go
The commisaires decided that the Jumbo-Visma man had only eight seconds on Evenepoel when the latter flatted
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Academy2-0: UD Almería U19 'A' nearly there following ninth back-to-back winThe youth side competing in Division de Honor Juvenil went all out from the off against UD Tomares to secure a stab at Copa del Rey youth tournament
The youth side competing in 'Division de Honor Juvenil' went all out from the off at the Francisco Pomedio ground located in the town of Huércal de Almería
Alberto Lasarte's boys left the game on track in the first half
the teenage Rojiblancos took the lead courtesy of Valen's opener
The attacker finished with his left foot after playing a one-two on the edge of the area that allowed him to be unmarked and beat the UD Tomares goalkeeper
the lads from Almería slotted home the second of the game through Varó; the defender scored a thumping header through another great play down the right wing
UD Tomares spurned a chance against goalie Juanca
who kept a clean sheet for his team to earn all three points
The UDA under-19s achieved one more victory at home to make 9 consecutive wins in the league
Lasarte's side remain leaders in their tier ahead of Betis
the talented Rojiblancos are first on a better goal difference
There are 3 days left for the first half of the campaign to end
at which time the teams that qualify for the 'Copa del Rey Juvenil' youth tournament will be announced
UD Almería U19s 'A' would have access to one of those places
The UD Almería youth team are travelling to Marbella to play against ninth-placed CD Vázquez Cultural within Group IV of the Division de Honor Juvenil tier
Goals: 0-1 Valen (11') 0-2 Varó (18')
played at the 'Francisco Pomedio' Field in the town of Huércal de Almería
TOMARES – Italian sprinter Matteo Trentin claimed his third win of the Vuelta a Espana on stage 13 as Chris Froome finished safely among the chasing pack to retain his overall lead on Friday
Quick-Step rider Trentin continued his dominance of the few sprint stages of the largely mountainous three-week trek around Spain by pipping compatriot Gianni Moscon and Denmark’s Soren Kragh Andersen to the line in a time of 4hr 25min 13sec
I came to this race with confidence but never expected anything like this,” said Trentin
“For the team the Vuelta is not finished and we are betting for more.”
who is aiming to become just the third rider to win the Tour de France and Vuelta in the same year
retains a 59-second lead over Italy’s Vincenzo Nibali
Saturday’s stage promises another showdown between the race favourites with a gruelling uncategorised climb to end the 175km ride from Ecija to Sierra de La Pandera
“It’s very difficult to predict what is going to happen in this Vuelta
As we saw yesterday things can change so quickly,” said Froome
“Tomorrow’s final is very steep
I expect guys like Alberto Contador and Vincenzo Nibali want to make up time at this stage of the race
“I expect a very aggressive ride from them.”
Another summit finish also awaits on the Sierra Nevada on Sunday and Froome is expecting this weekend to be decisive in his quest to finally win the Vuelta after three second-placed finishes
“Sunday’s stage is going to be even harder again up in the Sierra Nevada
“For sure at the end of a really tough week
we are going to see some really big time gaps in these next two stages.” – Nampa-AFP
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