Spain began participating in space projects in 1966 Airbus has come a long way and has the necessary competencies to lead the Spanish space sector Airbus has been present in all the major milestones that have shaped space in Spain We have paved the way in satellites and started work on launchers We are pioneers in the use of carbon fiber and a centre of excellence in composite materials We were also the first to make the leap into systems work being the only Spanish company with the necessary capabilities for the development and construction of large satellites The potential developed thanks to the dedication and high qualification of our teams has made Airbus the reference company in cutting-edge space technologies in Spain This leadership entails the commitment to be a driving force in the space sector that generates work and technological wealth both for other companies and for universities and research institutions.  Earth observation is one of Airbus' strengths in Spain. Right now Airbus is the prime contractor for ESA's Copernicus environmental mission called LSTM (Land Surface Temperature Monitoring) which aims to provide global measurements of the Earth's surface temperature at high space and diurnal velocity to make agricultural production on farms more sustainable LSTM is the first Copernicus mission awarded to a Spanish company Being selected to lead this mission is an important milestone for Spain and again demonstrates ESA's confidence in Airbus as a reliable partner for ESA's major missions The industrial consortium is composed of more than 45 companies and institutions from up to 18 different countries Moreover, within the European Copernicus program, Airbus has participated in the climate observation and control missions: Sentinel-1 being responsible for the thermal control of the satellite being responsible for the satellite structure and Sentinel-3 being responsible for the payload radiometer showing the European leadership in this type of radiometric instruments the Spanish radar satellite launched in 2018 It has a Spanish technology radar which produces high-resolution images Airbus led a consortium of 15 companies and 3 universities for its realisation The development of the Spanish optical observation satellite INGENIO was also led by Airbus which selected a group of 10 Spanish companies to carry out its design and construction one in panchromatic band and 4 multispectral bands but a failure in the launcher prevented its commissioning The successful development and qualification of the satellite established the capacity of Airbus and the Spanish space industry for these highly complex Earth observation missions Airbus was also instrumental in the design and manufacturing of the composite structures of the Meteosat MTG satellites and of the high thermo-elastic stability structures of the Meteosat MTG instruments for meteorological control In addition, Airbus in Spain has contributed with instruments and payloads to other missions such as: the MIRAS radiometer for the SMOS mission and the SCA antenna and ICI radiometer for the MetOp-SG mission telecommunications satellites also benefit from Airbus' technical expertise in Spain More than 150 telecommunications satellites incorporate the company's reflector antennas The active antenna that Airbus developed in Spain was a scoop in the European commercial communications area This was the ELSA+ antenna created for Eutelsat's Quantum satellite which can be electronically reconfigured in orbit offering the operator maximum flexibility to control the radio frequency beams in the coverage area with commands from ground Airbus in Spain is a world reference in secure communications for governmental use since more than twenty years ago with the development of the first IRMA active antenna for the Spainsat mission With successive developments and products in orbit it has gone a step further by developing the most technologically advanced payloads for satellites which represent the largest space programme ever launched in Spain The Governmental operator Hisdesat has contracted Airbus to lead the construction of two satellites Airbus in Spain is designing and building the X-band payload which uses active transmit and receive antennas with in-orbit reconfiguration capability offering greater flexibility thanks to the electronic reorientation of the beams depending on the coverage needs at any given moment The antenna is also capable of anti-jamming or diverting from intentional interference The first satellite will be launched early 2025 with a Falcon-heavy launcher Airbus has won the contract to develop the active antennas for the German secure communications satellite ADLER.   In Science and Exploration, the contribution of Airbus in Spain has been prolific and highly motivating, being involved in missions to Mercury, Jupiter, Saturn, Venus and Mars. Airbus Spain manufactured the structure of the Huygens probe that discovering for the first time an extraterrestrial world full of methane it made a number of measurements and images during its descent and landed on the surface with the help of a parachute Other adventures such as: chasing a comet (Rosetta), mapping one billion seven hundred million stars in the Milky Way (GAIA), or going to Mercury at a reduced speed to avoid being absorbed by the gravitational pull of the Sun (BepiColombo) have been an incredible technological experience and an effort that has been richly rewarded Airbus in Spain has also played a key role in the CHEOPS mission known as the exoplanet hunter CHEOPS is the first ESA satellite won by Spain It was launched into space in December 2019 with its telescope that characterises planets in nearby stars with high-precision photogrammetry The satellite was designed and built in Madrid by a consortium of up to 24 companies from 11 European countries led by Airbus Spain Its results are of great value to the scientific community Airbus has participated in ESA´s technological mission Proba-3 for the study of the solar corona,  being responsible for the design manufacturing and integration of the platforms of the two satellites -occulter and coronagraph- and carrying out the environmental mechanical and thermal tests of the complete spacecraft these two satellites will observe the solar corona during eclipses caused by the occulter satellite This mission will be launched into orbit at the end of 2024 by the PSLV launcher ESA is working in collaboration with the Chinese Academy of Sciences on the SMILE mission to study the perturbations of the Earth's magnetic field due to the solar wind Airbus is playing a key role in this mission by being the prime contractor for the intelligent payload that houses all the scientific instruments The Chinese platform and payload will be integrated at ESA's facilities in Europe The launch with the VEGA-C rocket is planned for late 2025 /early 2026 when the prediction of the interaction of the solar flux with the magnetosphere is more intense.  This requires a very powerful transport that can take them out of the atmosphere by overcoming the gravitational pull of the Earth In order to defy this attraction and reach its orbit it is necessary to reach a speed of 7.2 km/sec.  put two 5.5 ton satellites into orbit at each launch The large structures that made up the upper stage of the launcher were produced in Airbus Madrid using the most advanced carbon fiber technology.  Ariane 5 did its last flight in July 2023 and was replaced by Ariane 6 whose maiden flight took place in July 2024 Airbus in Spain continues to build the upper stage structures from the new state-of-the-art 4.0 facility in Getafe (Madrid) with a Pulse Line manufacturing and assembly facility Airbus in Spain also produces elements for American and Japanese launchers (Falcon-9 we encounter the International Space Station (ISS) The ISS is our science laboratory in space Experiments are conducted there to advance major scientific discoveries of great utility for our planet liquid and solid state physics and plasma research more than 1,800 experiments have been carried out Airbus in Spain has contributed to the construction of the five European ATV space freighters (electronic structures and units) that carried materials and supplies to the ISS The ISS also has windows for astronauts to make observations of the Earth and to control the installation of new elements on the station with the robotic arm Nodes 1 and 3 of the station have seven windows that must be protected from any micrometeorite impact Airbus in Spain supplied the covers that protect these windows which open and close from the inside using special watertight mechanisms.  Airbus is developing the Starlab module to continue the activities of the ISS which will reach the end of its life in 2030 Starlab will be able to accommodate between four and eight astronauts on its three floors to ensure seamless continuity of the research currently being conducted in orbit Airbus' commitment in Spain is not limited to exploiting the benefits of space to improve life on Earth A task that is considered essential is the dissemination of space knowledge to the younger generations to promote a love of science and space Airbus encourages its employees during Space Week to give presentations at schools institutes or associations to explain what space activities are what benefits they bring and to convey their enthusiasm for working in this industry workshops and conferences inspire young people not only to look at space but also to take an interest in science Airbus in Spain does not limit itself to that specific week and helps its ambassadors from all schools in Spain to go out throughout the year so that their message reaches more than five thousand young people Barajas hosted Airbus' main space activities in Spain This is where the two Spanish Earth observation satellites (PAZ and Ingenio) and also the first ESA satellite led by Spain (the exoplanet hunter CHEOPS) were built Airbus in Spain has proven to be a reliable partner for ESA in all fields: Earth observation It is the only company in the sector with the capacity to design and build large satellites as prime contractor integration and verification facilities in a clean area are unique in Spain Its organisation  is fully qualified to lead large programmes of the ESA the Spanish Space Agency and the Ministry of Defense through Hisdesat Participation in the Ariane programme includes large carbon fiber structures made in a single piece The transition from Ariane 5 to Ariane 6 has required the construction of new state-of-the-art 4.0 facilities at the Getafe plant with a Pulsed Line for the manufacture and assembly of Ariane 6 (22,000 m2) The satellite integration area, with 14,000 m2, is one of the largest in Europe. It has integrated the SMILE payload module, the latest generation active antennas for Spainsat NG, and is working on the antennas for the Metop SG and Galileo wind scatterometer The Airbus Tres Cantos Centre is located 25 km north of Madrid It specializes in designing and manufacturing electronic equipment for satellites orbital infrastructure and space transportation vehicles Spain is on Mars thanks to Airbus' Tres Cantos and Barajas centres Tres Cantos developed the REMS weather station for NASA's Curiosity rover It also contributed to the Perseverance rover of the Mars 2020 mission with another weather station (MEDA) Key elements for the Artemis lunar exploration programme are being developed in Tres Cantos. Among them, the Thermal Control Unit of the European Service Module of the Orion spacecraft the energy management subsystems of the HALO and I-HAB modules of Gateway are designed and manufactured at the Tres Cantos facilities For 40 years, it has been developing state-of-the-art electronics that are on board the Copernicus programme satellites, on more than 100 telecommunications satellites and on many of the European science and exploration missions, such as JUICE and Bepi-Colombo which are travelling towards Jupiter and Mercury Ariane has been a reference programme since the creation of the Tres Cantos Centre Starting with the development of sequential electronics for Ariane 5 the centre has been present in all European institutional launchers contributing to Europe's independent access to space The Connected Intelligence business in Spain is headquartered in Barcelona This entity provides digital geospatial services.  This team develops complete geo-information solutions StratObserver is also compatible with other types of HAPS Airbus GeoTech also performs 2D and 3D mapping including topographic maps for the civil and military markets aeronautical mapping of airports and generation of terrain obstacle databases Other activities such as cartographic and Geographic Information Systems consulting projects as well as geospatial software development are also carried out from this centre.  Airbus GeoTech is also a provider of satellite imagery for Airbus satellite constellations such as Pléiades Neo and its derivative products Airbus GeoTech provides its services to both national and international customers Airbus delivers innovative spacecraft and satellite systems for many applications from science and exploration to communications… Airbus has not only ‘given birth’ to Airbus aircraft Airbus people make up around half those working in the space industry in Germany An integral part of the £18.9 billion UK space sector Netflix hosted a celebration event to inaugurate the expansion of its production hub in Madrid Tres Cantos and highlight their commitment to the creative community in Spain The day featured creators and producers sharing their experiences working at Netflix’s first production facility in Europe that houses 10 stages and a state of the art post production facility Kicking off the day were tours of the set of Élite led by creator Carlos Montero and The Society of the Snow from Director J.A Bayona and producers Belén Atienza,Sandra Hermida Netflix’s Global Head of Partnerships and Business Development and heard from Verónica Fernández Director of Series for Spain and Portugal and M-K Kennedy Secretary of State for Telecommunications and Digital Infrastructure also addressed the crowd about the state of the audiovisual industry in Spain The stages have housed some of Netflix’s biggest productions from Spain including Élite and the global phenomenon La casa de papel Since our first Netflix production in Spain in 2016 we have created over 10,000 jobs worked with over 40 local production companies We continue to bring our members a wide variety of series and films made in Spain including over 30 titles in 2022 including Élite The expansion at Tres Cantos will enable Netflix to bring original stories ‘made in Spain’ to the world with upcoming highlights in 2023 including films such as Hermana Muerte A través del mar; or TV shows such as El silencio Un cuento perfecto; the new seasons of Sky Rojo Valeria or Élite; or nonfiction titles such as the new season of Soy Georgina and Oriol Paulo took the stage for a panel on “New Stories Made in Spain” to discuss their experiences working at Tres Cantos and more broadly about telling stories in Spain that are watched by the world on Netflix Highlights from the conversation include:  director and creator of El Inocente and Los renglones torcidos de Dios announced that he is working on a new project for Netflix that will be a thriller “is a wonderful excuse to explain the human condition and challenging the spectator.” Paulo also wanted to emphasize the importance of all his collaborations with the company being based on a commitment “for creative freedom and respect for the figure of the creator” Álex Pina and Esther Martínez Lobato unveiled the first drafts for the atomic bunker in which their new series will take place we were inspired by the proliferation of bunkers around the world We imagined a subway urbanization where the focus The big question this project addresses is: does life still go on even while the world is ending.” In relation to the spin-off of La Casa de Papel that they are currently producing Esther added: “Developing Berlin is a responsibility because it starts from a connection that already exists with the viewers and we want to continue deepening this emotion.” El desorden que dejas and Todas las veces que nos enamoramos expressed that's why when we create a series we want to reach the world but when you work for a company like Netflix producer of A través del mar and A través de mi ventana spoke about the connections with the fans of this phenomenon saying “We’ve felt accompanied by the fans in every step of this project They’ve been loving and caring while we witnessed how the phenomenon was growing in Spain and how the book and the book feed back to each other.” in which every part of the world will add to the storytelling the possibilities of telling this kind of stories is easier.” In addition speaking about the production hub in Tres Cantos the Pastor brothers remarked that the hub allows them to “tell stories big and ambitious in which the only limit is the desires of the own creator.”  Tres Cantos City Council has presented the Investment Plan for 2025, which will mean a historic transformation of the municipality. | EDATV LIFESTYLE Tres Cantos Leads Its Biggest TransformationThe City Council will allocate more than €27M to sports and urban planning01/03/2025 14:01:00h by Juan Manuel Pulido The Tres Cantos City Council has presented the Investment Plan for 2025 which will mean a historic transformation of the municipality With an investment exceeding 27 million euros culture and urban planning will be developed has highlighted that this plan will allow for an "ambitious leap into the future," consolidating Tres Cantos as a benchmark in the Community of Madrid Paraninfo is going to be the future facility of Tres Cantos We are going to recreate a large park on a plot pedestrian areas and water will play an important role "Paraninfo is going to be the future facility of Tres Cantos pedestrian areas and water will play an important role." This is how the mayor of Tres Cantos One of the most outstanding projects is Paraninfo the largest facility complex under construction in Spain (135,000 square meters) dedicated to leisure and culture integrated into a privileged natural environment a nursery school and a family leisure center Paraninfo will receive 6.5 million euros to advance its infrastructure the Concha Espina municipal library will be built and the works of the Gran Teatro Ciudad de Tres Cantos will begin | EDATVThis theater will house the second largest stage box in the region in the future 1.5 million euros will be allocated for landscaping the area The sports section will receive 10.5 million euros The construction of an indoor paddle tennis pavilion will begin and the covered sports center of the Parque Norte complex will be completed the athletics track will be remodeled and LED lighting will be installed on the Jaime Mata football field The squash courts at the Polideportivo de La Luz and the tennis courts at Embarcaciones will also be improved Funds will be allocated for the project of the third indoor pool and gym in Paraninfo Construction of an indoor padel pavilion will begin and the covered sports complex at Parque Norte will be completed | EDATVEducation: Modernization of Schools and New Nursery SchoolThe investment in education will amount to 2.8 million euros The modernization of schools will continue following the model of future classrooms the comprehensive remodeling of the Columbia and Nejapa schools will be a priority as they will teach the first cycle of Secondary Education next school year The installation of covers in school courtyards will also be completed with that of Miguel de Cervantes one million euros will be allocated to start the construction of the new Nursery School in Paraninfo Other projects include drafting the expansion plan for the Municipal Senior Center will have 500,000 euros for new outdoor sports areas 400,000 euros will be allocated for improvements on Almazara Street in the industrial area and 700,000 euros to renew the paving on Avenida de La Vega 500,000 euros will be invested in new unique children's areas and in drafting the Urban Salon project The latter will be a 3.7-mile (six-kilometer) promenade that will run through the city from end to end Tres Cantos consolidates itself as one of the cities with the greatest development and quality of life in the Community of Madrid You are using an outdated browser. Please upgrade your browser to improve your experience You have accessed https://www.emdgroup.com, but for users from your part of the world, we originally designed the following web presence https://www.merckgroup.com Merck is a vibrant team of specialists in Electronics We share a love of science and a passion for technology Merck ideas are everywhere – they can be life-changing or be integral to the objects we rely on every day Research is at the heart of everything we do At Merck we translate science and technology into internal innovation and external partnerships that have the power to changes lives we’re keeping digitalization at the forefront of it all Smart Manufacturing: Transforming the Factory Shopfloor Explore the latest news from the Merck media center and stay up-to-date with our upcoming events Contract Manufacturing Brings Us Closer to the Sci-Fi Reality of mRNA The investors' section of Merck provides everything shareholders and potential investors need to know about the company Full-year 2024: Merck Delivers Profitable Growth today celebrated a major expansion of its biotech plant in Tres Cantos resulting in a 50% increase in the facility’s production capacity Tres Cantos is Merck’s main site for the production of the active substances of its fertility treatment Gonal-f® and growth hormone disorders treatment Saizen® for the whole world “The demand for our core portfolio of medicines keeps increasing worldwide,” said Simon Sturge Chief Operating Officer of the biopharma business of Merck “The expansion in Tres Cantos is part of our continuous commitment to deliver high quality medicines at the right time to our patients.” “We are continuously investing in our manufacturing network to maintain state-of-the-art industry level and adapt its capacity to patient needs for our medicines,” added Thierry Hulot Head of Global Manufacturing and Supply for the biopharma business of Merck “We are very pleased to have completed the expansion of our Tres Cantos biotech manufacturing facility which plays a leading role in our manufacturing network and exemplifies our culture of safety at work adds 900 m2 of biotech production space and a two-floor office building bringing the total constructed area of the Tres Cantos site to 8,000 m2 The facility complies with the highest international cGMP (current Good Manufacturing Practices) quality standards It also observes the highest international standards in terms environment It is certified by ISO 14001 environmental management and safety by OHSAS 18001 The site employs 170 highly qualified professionals Merck has invested around € 250 million in its healthcare manufacturing network all over the world Merck is the world's oldest pharmaceutical and chemical company The founding family remains the majority owner of the publicly listed corporate group Germany holds the global rights to the Merck name and brand The only exceptions are the United States and Canada MilliporeSigma and EMD Performance Materials Merck and biopharmaceutical company SpringWorks Therapeutics have entered into a definitive agreement for Merck to acquire SpringWorks joint venture between Thales (67%) and Leonardo (33%) inaugurated today its new satellite integration clean room in Tres Cantos (Madrid); with the presence of the Minister of Science and Innovation of Spain Pedro Duque and of high representatives of the Spanish institutions and Industry This unique cutting-edge facility represents an important step forward in the company’s development strategy in Europe and a qualitative leap in the capacities of the space industry in Spain for the assembly integration and tests (AIT) of large space systems something within the reach of only a few space powers worldwide “This brand new clean room is the sign of Thales Alenia Space's determination to develop its  activities  in Spain in line with the company’s global development strategy to meet the evolving needs of its customers and of the space market ” The new clean room will add more than 600 m2 clean area to the existing 2000 m2 clean area at the site of Thales Alenia Space in Tres Cantos With a free height of 12.5 meters in the inside (20 meters high building) it is equipped with bridge cranes with lifting capacity up to 12 tons allowing the integration of large satellites payloads and instruments for all types of space missions The construction of this facility began in July 2019 and did not cease despite the difficult conditions caused by Covid-19 “This new facility will allow us to carry out in Spain activities of high added value with all the implications that it has regarding the creation of high quality employment and the strengthening of the space ecosystem in Spain The new capabilities will boost the competitiveness of our national space industry” This building will enable to carry out high-scale activities such as the integration in a few months of the Communications Module of SPAINSAT NG Spain’s new generation governmental satellites owned and operated by Hisdesat which houses the satellite’s communications payloads is a 6-meter high structure weighing nearly two tons that will become the largest satellite system ever integrated in Spain to date Thales Alenia Space leads in Spain the development of the communications payloads in UHF and military-Ka bands for both satellites This is the first time that Spanish industry leads the construction of satellite communications payloads an important milestone in scope and complexity Minister Pedro Duque has pointed out that “space is a sector that has been offering solutions and well-being to our society for many decades but its relevance will grow in the coming years due to the acceleration of some processes caused by the pandemic Thales Alenia Space's investment in our country and the creation of a considerable number of quality jobs are already tangible benefits of this commitment to the future that represents the space sector” The minister recalled the Government's commitment to the space sector and was convinced that "it will serve to create wealth and employment and sustain our welfare state because generating wealth with scientific discoveries and innovation must be part of our commitment to society." Thales Alenia Space has already participated in 600 satellites space probes and space vehicles for space agencies and satellite operators around the world for which it has manufactured more than 4,000 equipment and systems at its site in Tres Cantos that accumulate more than 200 million hours of operation in orbit Thales Alenia Space in Spain is a specialist in satellite communications systems with solid heritage in TT&C and data transmission systems for all types of space missions and orbits including missions in low Earth orbit (Sentinel 1-2-3 science missions in orbit around the L2 Lagrange point (Herschel The company makes another key step up in the value chain with the inauguration of the satellite integration clean room Thales Alenia Space was selected by ESA and the European Commission to play a major role in the two European emblematic programs Copernicus expansion and Galileo Second Generation as prime contractor Thales Alenia Space in Spain is strongly involved by providing key equipment and systems for the six new Copernicus missions as well as the communications and several critical technologies of the six new Galileo satellites There are no statistics available for this player Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Danone is investing in increasing the capacity of its dairy production facility in Tres Cantos A spokesperson for the company told just-food the group is introducing a new line at the site “The new production line is dedicated to [our] Danet [yoghurt] product and the investment has been EUR3.9m (US$5m),” the spokesperson said The line has the capacity to produce 250m units of Danet per year Products will primarily be sold in Spain with some distribution in markets such as France and Portugal Don’t let policy changes catch you off guard Stay proactive with real-time data and expert analysis Nominations are now open for the prestigious Just Food Excellence Awards - one of the industry's most recognised programmes celebrating innovation This is your chance to showcase your achievements Don't miss the opportunity to be honoured among the best - submit your nomination today Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network 2013) — Despite major advances in high-throughput screening and genomic technologies tuberculosis (TB) drug development remains hindered by a general inability to measure the effective penetration of chemical compounds into Mycobacterium tuberculosis bacteria (Mtb) which cause TB the Tres Cantos Open Lab Foundation has awarded Weill Cornell Medical College funding to support a visiting Weill Cornell microbiologist's two-year research project at the Tres Cantos Open Lab in Spain to measure and analyze the permeability of chemical compounds into Mtb using novel metabolomics technology The new Open Lab research project seeks to identify broader chemical principles that could be used to transform potential potent chemical inhibitors into active drugs a key bottleneck in current anti-infective drug research The goal of the research project will be to monitor the intracellular accumulation of diverse potential drugs and reveal the associations between cell permeability and anti-TB activity using metabolomics technology developed by Weill Cornell The Tres Cantos Open Lab is based at GlaxoSmithKline's (GSK) Tres Cantos Medicines Development Campus in Spain a post-doctoral researcher at Weill Cornell will work as an Open Lab Scientist in an integrated team alongside researchers from GSK and will have access to resources chemical compounds and laboratory space to perform this novel TB research project Raheem will screen and analyze hundreds of potential anti-tuberculosis compounds from GSK's compound library this research may lead to the advancement of TB drug development by informing researchers on the predictive physicochemical characteristics needed for a given compound to effectively permeate Mtb "This is a project that will help to understand what chemical properties are needed for activity against Mtb," says Professor Sir Leszek Borysiewicz trustee and chair of the Governing Board at Tres Cantos Open Lab Foundation "It could set the foundations to design better anti-TB drugs." This new research at the Open Lab builds upon findings published in Science in November by infectious disease expert Dr. Kyu Rhee who is Weill Cornell's principal investigator for this Open Lab research project The recent study demonstrated current mass spectrometry technologies could be repurposed to study existing TB drugs and directly visualize what happens as they infiltrate TB cells This study was the first to show mass spectrometry technology can be adapted to understand the action of antibiotics on living Researchers "watched" at a basic biochemical level how one TB drug was able to both enter and inhibit Mtb while another drug's failure to inhibit Mtb was found to be due to its extensive degradation once inside rather than its inability to enter the bacterium "We have adapted our metabolomic tools to monitor the intracellular accumulation transformation and biochemical events of currently available drugs against Mtb mass spectrometry can now be used to test new chemical compounds as well as the current cocktail of drugs used to treat TB who is also an associate professor of medicine in the Division of Infectious Diseases and associate professor of microbiology and immunology at Weill Cornell and now the latest metabolomics assay we developed and are testing we aim to design and test the much-needed next generation of effective anti-TB agents." This new research project is the second project by Weill Cornell in the Tres Cantos Open Lab. In 2011, Dr. Carl Nathan chairman of the Department of Microbiology and Immunology Rees Pritchett Professor of Microbiology and the director of The Abby and Howard Milstein Program in the Chemical Biology of Infectious Disease at Weill Cornell a postdoctoral fellow in the Nathan Lab to work for a year at the Open Lab Warrier successfully screened 269,000 GSK compounds against TB a second postdoctoral fellow from the Nathan Lab arrived in Tres Cantos to continue the Open Lab research project begun by Dr The Tres Cantos Open Lab Foundation is focused on providing funding and support for scientists, academics and institutions to develop and advance new ideas that could lead to new medicines to treat diseases of the developing world. Researchers are invited to submit projects for collaboration and funding, to be reviewed by the Foundation's Governing Board and Trustees. http://www.openlabfoundation.org Back to News The island school’s middle-school choir earned the highest accolade for its recent Carnegie Hall performance in New York and the students will treat the local community to an encore show The Sanibel School’s Seahorse Chorale took the big stage at the New York Invitational Music Festival in New York City Music Director Joey Giangreco reported that 27 students traveled to the Big Apple to perform at the festival plus they had the opportunity to enjoy a bit of sightseeing He reported that the chorale first performed in the hall early in the day for the sound check “Just walking out onto the stage was humbling Knowing all of the musicians and performers who had performed there before us,” Giangreco said “Seeing my students perform on that stage was an incredible and magical experience.” “They knew this was something very special truly a once-in-a-lifetime experience,” he said The chorale performed five songs for the festival which were “Dreams that Children Dream,” “We Know The Way,” “Tres Cantos Nativos Dos Indios Krao,” “Sing For Joy” and “For Good.” “I spent a lot of time thinking about the messages that we wanted to portray and I wanted to make sure we brought a variety of musical styles to the performance,” Giangreco said noting that his students chose the order of the songs “Dreams that Children Dream” showcased their voice ranges and aimed to reflect their Big Apple dreams while “We Know The Way” from the movie “Moana” spoke to the importance of one’s island home and knowing one’s roots “Tres Cantos Nativos Dos Indios Krao” served as a world piece that featured another culture with three Brazilian folk songs “For Good” came from the Broadway musical “Wicked” as the chorale got to work with a cast member plus it represented friendship and memories He reported that his students worked hard to prepare and delivered a high-quality performance Giangreco explained that prior to the show they told the organizers that they wanted to perform for comments only — not for a rating the night of the performance during the awards ceremony the judges and production company presented the chorale with the gold plaque — the highest rating “It was an incredible surprise and honor,” he said “It meant the world to my students and myself.” the chorale visited the top of Rockefeller Center enjoyed a backstage tour of Radio City Music Hall “They had the opportunity to experience New York City,” Giangreco said He thanked Troen Student Performance Events and Music Celebrations International an Appreciation Performance will be held on April 24 from 6 to 7:30 p.m The students will perform their Carnegie Hall set “This is something the students will remember forever and it was not something we accomplished alone,” Giangreco said of taking part in the festival in New York “This is a way for us to say thank you to the community and all the sponsors and donors who helped to make this trip a possibility for us.” attendees will see a slideshow of pictures taken during the New York trip they will enjoy slices of New York-style cheesecake served up by the students To RSVP, visit https://www.paperlesspost.com/go/0qDmvbQIm6BKeMiVyV3dN “We look forward to celebrating with the community and celebrating bringing back the gold from New York City,” he said The Captiva Civic Center is at 11550 Chapin Lane The Sanibel School will present its Spring Music Showcase on April 25 at 6:30 p.m The annual concert will feature the Elementary Choir along with a sneak peak of the Performing Arts’ upcoming production of Disney’s “Mary Poppins JR.” “It’s songs from and inspired by ‘Mary Poppins JR,'” Giangreco said of the program The Elementary Choir will perform “Believer,” “Supercalifragilisticexpialidocious,” “The Place Where The Lost Things Go” and “Kuwa Furaha.” The Orff Club will present an arrangement of “Don’t Stop Believing,” an improvisation song of “Highland” with drumming and arrangement of “Entrance of the Gladiators.” The Seahorse Chorale will perform selections from its Carnegie Hall set tickets are $5 for adults and ages 18 and under are free “We will have the concession stand available for food and drink purchases,” he said The proceeds will support the Music Department The Sanibel School is at 3840 Sanibel-Captiva Road Tickets are $5 and ages 18 and under are free Copyright © SANIBEL-CAPTIVA - Island Reporter, Islander and Current | Contact | Terms of Use | Privacy Policy The director of CNIO remains in the news | EDATV NEWS This is the brutal wealth of the CNIO directorHighlights a 1,665 square meter (17,922 square feet) chalet in Tres Cantos two properties and a plot of land in Galicia among others29/01/2025 06:30:00h by Gonzalo Pinilla The director of CNIO continues to make headlines María Blasco has been the subject of much discussion due to her assets which include a 1,665 square meter villa (17,922 square feet) in Tres Cantos (Madrid) in addition to a rustic estate in Alicante she owns a 40 square meter (431 square feet) apartment Located in the central Justicia neighborhood in Madrid and its estimated value according to the Idealista portal is around 350,000 euros Also two properties and a plot of land in Galicia in addition to a rural estate in Alicante | Europa PressMeanwhile the villa in Tres Cantos consists of a two-story family house Its construction occupies 516 square meters (5,554 square feet) while the rest corresponds to the land surrounding the property This asset was purchased at the time together with her ex-husband Blasco obtained full ownership after the dissolution of the marital partnership María Blasco and her current partner own several properties in Galicia they acquired two houses and a plot of land with the intention of establishing a garden One of the houses is located in the coastal area of Caldebarcos the property has two floors of 79 square meters (850 square feet) each in addition to a 22 square meter (237 square feet) shed on the ground floor It also includes a 110 square meter (1,184 square feet) patio which covers a total of 443 square meters (4,768 square feet) It includes a 63 square meter (678 square feet) house which occupies 156 square meters (1,679 square feet) and includes a "soleiro" of 65 square meters (700 square feet) The property also includes a garage and a patio the estate has 268 square meters (2,885 square feet) built they also own an estate in Carnota | Europa PressIrregular PaymentsBlasco has irregularly received a total of 319,000 euros in "extra payments" between 2016 and 2024 were received by the director of CNIO without entitlement along with additional payments for royalties that she was also not entitled to the General Intervention of the State Administration (IGAE) alerted CNIO about this irregularity the Ministry of Finance department indicated that Blasco had received a total of 90,197 euros Money in non-corresponding supplements for the years 2016 Metrics details present a set of useful guiding criteria on what constitutes a hit or a lead to initiate a drug discovery programme against tuberculosis (TB) But what will be the origin of future small-molecule starting points What mechanisms are currently in place to ensure that the early-stage pipeline for diseases of the developing world remains healthy Taking stock from epidemiological realities in areas such as microbial infections a sustainable research and development (R&D) effort to address the continuous threat of drug resistance will be required This effort will need to go beyond the earlier phase of 'standardized' phenotypic screening in which hit molecules were identified and progressed by virtue of their anti-proliferative activity against parasites and bacteria This potential gap is further compounded by the slow but steady shift of focus and funding from preclinical to clinical research as the current pipeline matures and the naturally high attrition rates affecting drug discovery continue unabated new community-wide R&D models based on continuous and open innovation will be required to re-invigorate hit- and lead-identification activities Albeit a crucial first step to initiate collaborative research it was envisaged that the release of proprietary screening data would not be sufficient to facilitate the creation of a virtual community of scientists working on a sustainable pipeline for diseases of the developing world and questions remained about how best to articulate coordinate and financially sustain such a community These concerns underpinned the creation of the Tres Cantos Open Lab Foundation (TCOLF) Prices may be subject to local taxes which are calculated during checkout Hit and lead criteria in drug discovery for infectious diseases of the developing world Thousands of chemical starting points for antimalarial lead identification Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource A new set of chemical starting points with Plasmodium falciparum transmission-blocking potential for antimalarial drug discovery 3,5-diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M Download references Department of Diseases of the Developing World Division of Biological Chemistry and Drug Discovery are currently employees of GlaxoSmithKline and share stock in the company are currently Board members and Trustees of the Tres Cantos Open Lab Foundation Schematic representation of the impact of GlaxoSmithKline and Tres Cantos Open Lab Foundation (TCOLF) activities on the current global preclinical and clinical portfolios for tuberculosis (TB) Download citation Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Close Looking for Wellcome Collection? bannerWellcome homeSearchMenuMenu iconClose menuHomeResearch fundingResearch funding We fund research around the world, across a broad range of disciplines, to understand life, health and wellbeing and to deliver equitable health solutions. Engagement and advocacyEngagement and advocacy We work with communities, governments and partners across the world to advocate for evidence-based health policies that support the communities most affected. We're bringing together expertise from across science, innovation and society to generate new knowledge and find equitable solutions to improve life, health and wellbeing. Read our articles and reports to learn more about our activities and impact supporting our mission. We are a charitable foundation with a vision of a healthier future for everyone. health and wellbeing and to deliver equitable health solutions governments and partners across the world to advocate for evidence-based health policies that support the communities most affected We're bringing together expertise from across science innovation and society to generate new knowledge and find equitable solutions to improve life Read our articles and reports to learn more about our activities and impact supporting our mission We are a charitable foundation with a vision of a healthier future for everyone Close searchSearchSearchHide SearchClose search and menuNicholas Cammack Chief Research Programmes Officer (Interim)Nick is the Interim Chief Research Programmes Officer at Wellcome leading a broad interlinked portfolio that focuses on discovery research and three urgent health challenges: mental health Of note, Nick established and implemented the Tres Cantos Open Lab Foundation (TCOLF) – a not-for-profit foundation that supports academic scientists to visit GSK in Tres Cantos to pursue their own drug discovery ideas, taking advantage of the expertise and facilities available there. This was a first for the Pharma industry and continues to be viewed as a bold, innovative step in neglected tropical disease drug discovery. Danone will invest €2 million during the next three years in a new wastewater system at its dairy plant in Tres Cantos, Spain. The investment will allow the facility to increase its water autonomy to 80%, and furthers Danone’s goal to become self-sufficient at the site north of Madrid. The move will make the Tres Cantos factory more economical with its water usage – currently, it uses 800 cubic metres of water every day to support capacity of 4 million yogurts and custards. The new wastewater system will capture residual water from the factory’s activities, storing it and preparing it for reuse later on. After being filtered and purified, the water will be reused for purposes including cleaning, with the 80% water autonomy being phased in over the coming three years. “This is an innovative and pioneering project for the company with an ambitious goal – to be largely self-sufficient in our water needs,” explained Tres Cantos factory manager Alexandre Biau. “We are undoubtedly proud to undertake a project of this magnitude. Our challenge is, and will continue to be, to carry out our operations with maximum efficiency and sustainability.” The effects of climate change are now undeniable and increasingly costly; yet, making the business case for climate action remains a challenge. Join us on Thurs, May 15, as leaders from Climate Impact Partners, Kearney and Schroders share how leading companies are embedding sustainability into their business strategy; building resilience; and aligning cross-functional teams to deliver tangible, bottom-line impact. Tres Cantos is the most efficient factory in Danone’s European dairy business; the round-the-clock plant spans an area of more than 60,000 square metres and churns out almost 50 individual product lines. Published Mar 30, 2017 6pm EDT / 3pm PDT / 11pm BST / 12am CEST Text description provided by the architects. The Spanish Electricity Network commissioned IDOM for the complete rehabilitation of two buildings at the Tres Cantos Technology Park (Madrid). The operation comprises an integral adaptation to the new training and technological needs of the company, modernizing all the buildings through an environment that allows to comply the energy efficiency requirements. The distribution of the new campus seeks to increase the quality of spaces and classrooms, as well as an efficient organization, taking full advantage of the available space, generating clear and recognizable access areas, reducing and clarifying the area of the project destined to the common areas. Floor PlanFrom the formal point of view, the project seeks to value the particular spatial conditions of the building from four main elements: the closed communication and sanitary cores, the new inner courtyard, the organization of the plants and the exterior image of the building. © Aitor OrtizThe new inner courtyard aims to provide natural light to the central area of the building which is currently very dark. The appreciation of this new patio allows it to act as an open visual background from both levels of the building. Around the patio are organized the training and meeting rooms with natural light coming through the courtyard. Among them, the divisions will be formed by opaque panels to control the classrooms acoustics. Section SL1The current facade is composed of glass panels, some of them are inclined (on the main facade) and opaque areas formed by brick walls covered with monolayer mortar. The elimination of the inclined panel of the main facade is expected. © Aitor OrtizThe buildings are energetically rehabilitated in their entirety, applying passive strategies to improve their energy behavior: insulation in the roof, threshold and blind facades; glass and high-performance joinery; sun protection and infiltration control. It is made by a high technical level energetic performance in the building. © Aitor OrtizIn front of the facade was installed a metallic protection composed of galvanized steel sheets of variable opacity, supported by a main structure and joined by horizontal uprights of variable size according to the orientation of the facade, in order to avoid direct solar radiation. The proposal for the facades of the building seeks, on the one hand, to improve its thermal properties and, on the other hand, to improve its image without changing its volumetry. © Aitor OrtizThe environmental impact of the reform is minimal responding to the electricity grid standards and the needs of today's society You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email By 2022-11-22T15:11:00+00:00 Netflix has officially opened five more soundstages at its Spanish production hub in Tres Cantos just north of Madrid doubling the complex’s total number of studios to 10 The streaming giant inaugurated the studios today with an opening event for press industry execs and Spanish government ministers are hosting the seventh season of Netflix’s Elite Bayona’s disaster feature The Society Of The Snow and Charlie Covell’s upcoming UK series Kaos produced through Sister Netflix is making 30 Spanish productions this year Coming up for 2023 are films such as Hermana Muerte Talent including Money Heist showrunners Álex Pina and Esther Martínez Lobato Fry said there were four reasons for chosing to shoot Kaos a contemporary reimagining of Greek mythology at the Tres Cantos facility: the Spanish weather the country’s attractive tax credits and its strong crew base He said that because the studio has facilities such as make up through to post on site “it means you can keep your production close and tight.” Spain’s secretary of state for telecommunications and digital infrastructure talking up the government’s support for the creative industries Audiovisual Hub of Europe plan to invest €1.6bn by 2025 to boost production in the country stressed the new infrastructure being built at Tres Cantos meant the ‘technology is top notch” for incoming creatives Netflix’s head of global partnerships Maria Ferreras described Spain as a centre of audiovisual production in Europe and the world There was also a keynote with Verónica Fernández Netflix’s director of series for Spain and Portugal Netflix’s vice president production Europe. Guests were given tours of the set of Élite Tres Cantos first opened in 2019 and is now a multi-purpose space of more than 22,000 m2 Oscar winner proposing federal tax incentives Monday’s statement to reporters follows Truth Social The posting on Trump’s Truth Social platform is sending shockwaves around the world ‘Ish’ and ‘Learning To Breathe Under Water’ will also feature Company’s latest foray into genre will open theatrically on October 10 Screen International is the essential resource for the international film industry access to the Screen International archive and supplements including Stars of Tomorrow and World of Locations Site powered by Webvision Cloud Quetta Data Centers to build six facilities totaling 60MW Investment manager Azora is launching a new European Edge data center platform The company plans to invest more than €500 million ($538.5m) in constructing six Edge data centers in Spain and Portugal totaling 60MW of capacity but Azora said the six assets are predominately located in Madrid Quetta has already begun construction of the first data center in Madrid and is in negotiations to complete the acquisition of the land and construct facilities at other locations Azora said the facilities will utilize renewable energy and operate with a PUE below 1.15 said: "The launch of Quetta is part of our strategy of investing in sustainable infrastructure The digitalization of the economy offers very attractive investment opportunities in the data centers sector especially those aimed at companies that offer streaming content and other technologies such as artificial intelligence that will experience strong growth as the speed at which society and business consume data accelerates.” He said: "Quetta Data Centers seamlessly complements the current offerings in the Data Center market addressing the demand for proximity with interconnected geographical coverage This creates synergies with existing market operators leveraging the excellent conditions of the Iberian Peninsula.” Azora has €9.7 billion in assets under management; investments span residential and hospitality real estate as well as energy infrastructure and management of technology investment vehicles Azora’s Olivares continued: “This investment marks our first entry into the Iberian data centers market an asset class in which we hold a strong conviction and utilizes our deep expertise in both the local real estate market and in developing and owning operationally intensive assets." Data Centre Dynamics Ltd (DCD), 32-38 Saffron Hill, London, EC1N 8FH Email. [email protected]DCD is a subsidiary of InfraXmedia Metrics details Plasmodium falciparum stage V gametocytes are responsible for parasite transmission and drugs targeting this stage are needed to support malaria elimination We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P falciparum female gametocyte activation assay (Pf FGAA) which assesses stage V female gametocyte viability and functionality using Pfs25 expression We identify over 400 compounds with activities <2 μM chemically classified into 57 clusters and 33 singletons Up to 68% of the hits are chemotypes described for the first time as late-stage gametocyte-targeting molecules the biological profile of 90 compounds representing the chemical diversity is assessed We confirm in vitro transmission-blocking activity of four of the six selected molecules belonging to three distinct scaffold clusters this TCAMS gametocyte screen provides 276 promising antimalarial molecules with dual asexual/sexual activity representing starting points for target identification and candidate selection As both female and male gametes are required for the development of mosquito stages the parasite lifecycle may be interrupted by solely targeting one of them The objective of this study is the discovery of new chemical diversity with activity against both asexual blood stages and stage V (female) gametocytes that may not only treat clinical symptoms but also block malaria transmission The different steps followed during the TCAMS screen as well as the number of compounds identified in the first phases and those selected for further profiling are shown The first four steps can be defined as ‘hit identification’ compounds are progressed to characterize their biological profiles and finally tested in the gold standard SMFA 276 compounds (green circles and all stars) out of the 405 hits were exclusively identified in the Pf FGAA while 129 compounds (grey circles) were active in both assays Stars represent those compounds further profiled: slow-acting (blue stars) fast-acting (yellow starts) and gamete-targeting (magenta stars) Compounds tested in the SMFA are marked as big stars Clusters with three or less representatives comprised more than 70% of the set which is indicative of the large chemical diversity identified in this screen belonging to 24 of the 90 compounds profiled that are within an appropriate physicochemical space (clogP<5 The parasitological properties of the selected molecules were further investigated to assess their speed of action and activity against female gametocytes or gametes (Fig. 4 and Supplementary Data 3). Stage V gametocytes were exposed to the 90 selected compounds for 24 or 48 h to determine the drug inhibitory speed of action compounds were added after triggering gametocyte activation to evaluate their activity in female gametes The figure shows the number of compounds and chemical diversity classified under each category Moreover, when the compounds were added 30 min after triggering gametocyte activation, 12 compounds prevented cell surface expression of Pfs25 (designated as gamete-targeting; Fig. 4) This suggests that these molecules target female gametes directly although this does not discount the possibility that they are also active against stage V gametocytes Stage V gametocyte cultures were exposed to 2 μM of TCMDC-141070 and 1 μM of the five remaining compounds for 48 h. The percentage inhibition was determined compared to DMSO-treated controls. Compounds were then progressed into SMFA to further determine the transmission blocking in mosquitoes. Each bar represents mean value of two (TCMDC-125345, TCMDC-141698, TCMDC-123767, TCMDC-141154) or three (TCMDC-141070, TCMDC-124559) independent replicates with s.d. The following parameters were measured: (a) Transmission-blocking activity (prevalence reduction) and (b) reduction in mean P Each bar represents mean value of two (TCMDC-125345 TCMDC-124559) independent replicates with s.d Each experiment included a control group treated with vehicle (green circle) used as a reference to calculate the percentage of inhibition of parasitaemia in peripheral blood (dotted red line) The response of standard antimalarials in the same assay is also presented (blue log10 [% asexual blood stages at day 4] of two mice per point Additional in vitro ADME and in vivo pharmacokinetic studies were then performed to explain the lack of activity of these two compounds TCMDC-123767 was rapidly eliminated in vivo and was last detected in blood above the lower limit of quantification (LLOQ it also showed high in vitro microsome clearance (7.9 ml min−1 per g liver) TCMDC-140549 was estimated to possess moderate permeability through artificial membranes (170 nm s−1) which may drive a low oral bioavailability this paper reports the largest screening effort performed to date using an assay that utilizes P falciparum gamete formation as the endpoint The TCAMS library was screened in the Pf FGAA and 405 chemical-starting-points for antimalarial transmission-blocking drug discovery were identified Further analysis of these molecules revealed that 276 compounds (25% with selectivity index >10) belonged to chemotypes never described before as gametocyte-targeting molecules suggesting Plasmodium kinases as potential targets for these molecules Further investigations will be necessary to understand the mechanisms of action of these compounds and by publishing these structures we intend to stimulate research in this area From the point of view of malaria drug discovery the most practical way to interrupt the Plasmodium lifecycle would be through the clearance of transmissible stages present in the peripheral bloodstream of infected patients those compounds with a fast-acting profile would be preferred to those requiring longer exposure times almost 90% of the compounds tested in this study exerted their effect in stage V gametocytes (and asexual blood stages) but not in female gametes which revealed their potential utility for transmission-blocking strategies Further research would be required to determine if the 12 compounds active against female gametes also target stage V gametocytes and so might have an added value as multi-stage antimalarial drugs This suggests that compounds affecting both male and female gamete formation may lead to a more efficacious blockade of malaria transmission Subsequent pharmacokinetic analysis revealed very low exposure levels in blood for TCMDC-123767 which might explain the lack of effect of this molecule in the in vivo model Given that both compounds showed a good parasitological profile in vitro further studies to improve stability and bioavailability will be performed to address their potential use as antimalarial drugs Clearance of TCMDC-123767 and TCMDC-140549 may be reduced by blockade of labile positions whereas solubility of TCMDC-123767 may be increased by incorporation of polar and/or ionizable groups the Pf FGAA can identify potential transmission-blocking chemotypes which due to the biological content covered in this assay were undetected by previous gametocyte-based assays The TCAMS library screen yielded 276 new gametocyte-targeting molecules belonging to 57 diverse chemical entities and 3 biological profiles Nearly 25% of the hits identified are within the appropriate physicochemical space (clogP<5 number of aromatic rings <3) and will therefore be considered for further progression while other hits represent valuable starting points as tool compounds to identify new modes of action involved in the biology of Plasmodium transmission Cultures synchronized at the ring stage were used to start gametocyte cultures (day 0) at 1% parasitaemia and 4% haematocrit in 200 ml final volume using culture bottles (Nalgene 3110-42 Complete culture medium (RPMI 1640 supplemented with 25 mM HEPES 2 g l−1 NaHCO3 and 10% pooled human male type A+ serum) was totally replaced daily for 14 days without fresh erythrocyte addition Human serum was obtained from Interstate Blood Bank A+ serotype; no aspirin 2 h before drawing and no antimalarials 2 weeks before drawing which is crucial for gametocyte production and maturation pre-warmed medium and a slide warmer (XH-2001 parasitaemia reaches a peak of asexual stages on days 4–5 and the first gametocytes are differentiated in culture on day 6 Sexual-stage development was monitored microscopically by Giemsa-stained thin blood smears at day 7 (mainly asexual stages and stages I to III gametocytes) and day 14 (stages IV and V gametocytes) MRA-315) conjugated to the Cy3 fluorochrome (GE Healthcare) was added to ookinete medium (RPMI 1640 supplemented with 25 mM HEPES 100 μM xanthurenic acid and 20% human serum) at a final concentration of 0.5 μg ml−1 Activated cultures were then kept at 26 °C for 24 h protected from light and image acquisition was performed in the Opera High-Content Screening System (PerkinElmer) five images per well were taken using 532 nm excitation Images were analysed with a Columbus image data storage and analysis system (PerkinElmer) based on a script specifically designed for this assay that considers size roundness and intensity of fluorescence of the female activated gametocytes parasites (50 μl per well containing 12,500 gametocytes) were added to compound pre-dispensed 384-well plates (781091 Greiner Bio-One) and incubated at 37 °C for 48 h (3% O2 Promega) was used to determine the ATP levels of ‘live’ parasites according to the manufacturer’s instructions luminescence of the plates was measured using a microplate reader (HTS counter Victor Exflagellation was measured as previously reported24 with minor modifications parasites were incubated with the corresponding concentration for each compound in six-well plates at 37 °C (3% O2 a 200 μl sample was spun down in a microfuge the supernatant was carefully removed and the pellet resuspended in 15 μl of pre-warmed ookinete medium Parasites were placed in Fast-Read disposable haemocytometer slides and exflagellation centres per field were counted under × 10 objective ATCC) were detached from the culture surface and dispersed with 5 ml of Eagle’s Minimum Essential Media (supplemented with 10% FBS/1% NEAA solution/1% penicillin + streptomycin) by repeated pipetting Cell suspension was added to 500 ml of the same medium at a final density of 1.2 × 105 cells ml−1 and 25 μl per well were seeded in 384-well-plates with pre-dispended compounds (250 nl per well) using a Multidrop combi dispenser (Thermo Scientific); this number of cells (typically 3,000 cells per well) ensures that new monolayers were not more than ∼50% confluent at the time of seeding Cells were incubated at 37 °C and 5% CO2 in a humidified incubator for 48 h Promega) were equilibrated at room temperature for 30 min before proceeding to develop the luminescent signal 25 μl per well of the signal developer were added to the plates and after 10 min at room temperature for stabilization plates were read on the ViewLux system (Perkin Elmer) to assess the reduction of parasitaemia compared with the vehicle-treated mice Female CD-1 mice (Harlan Interfauna Iberica) at 8 weeks of age were used for single oral dose pharmacokinetic studies (n=2) Dosing solutions were prepared in 20% (v:v) Captisol in water at a target dose of 50 mg kg−1 (dose volume of 20 ml kg−1) blood samples (25 μl) were collected at 30 min All the blood samples were diluted with 25 μl of an aqueous solution of saponine 1% (w:v) Mice blood samples were analysed for each compound using a method upon protein precipitation followed by LC-MS/MS analysis (Applied Biosystems) Data analysis of the concentration time profiles was performed by noncompartmental methods by using WinNonLin Phoenix Version 6.3 Intrinsic clearance (CLi) values were determined in mouse liver microsomes (M1000 Test compounds (final concentration 0.5 μM) were incubated at 37 °C for 45 min in 50 mM potassium phosphate buffer (pH 7.4) containing 0.5 mg microsomal protein per ml The reaction was started by addition of cofactor NADPH (N1630 The final concentration of organic solvent (DMSO) was limited to 0.25% of the final volume quenched with acetonitrile containing an appropriate internal standard and analysed by HPLC-MS/MS (Applied Biosystems) CLi was determined from the first-order elimination constant by nonlinear regression corrected for the volume of the incubation and assuming 48 microsomal mouse protein per g liver Values for CLi were expressed as ml min−1 per g liver It is a 96-well plate-based assay that measures the speed of permeation of a compound (at 10 μM concentration) through a phospholipid membrane consisting in 1.8% egg L-a-phosphatidylcholine (830051 Avanti Polar Lipids) and 1% cholesterol (C8667 Phosphate buffer (50 mM Na2HPO4 with 0.5% 2-hydroxypropyl-b-cyclodextrin) is added to the top and bottom of the plate (S5EJ046I08 The lipids are allowed to form bilayers across the small holes in the filter and compound concentration is measured 3 h later in both donor and the acceptor compartments by HPLC (Agilent 1100 LC) Permeability (P) (nm s−1) is calculated using the following formulas: where X=VD/VR; CR and CD are final concentrations in receiver and donor side respectively; VR and VD are volumes in receiver and donor compartment respectively; A is the area (cm2) and t is the incubation time (s) The considered cut-off values are as follows: High: P>200 nm s−1; Medium: 10 nm s−1<P<200 nm s−1; Low: P<10 nm s−1 All the experiments were ethically reviewed and approved by the GlaxoSmithKline Diseases of the Developing World (DDW) Group Ethical Committee on Animal Research and were conducted according to Spanish legislation European Directive 2010/63/EU and GlaxoSmithKline policy on the Care Welfare and Treatment of Laboratory animals Compounds were dissolved in 100% DMSO and dispensed in the 384-well plates using an Echo-CRS liquid handler Compounds were tested in 2–3 independent experiments both positive (a drug highly effective against the biological process) and negative (the vehicle consisting in 0.5% DMSO) controls were added and a minimum of ten wells per plate were analysed Z′ factor was calculated for each plate and only those ones with values higher than 0.4 were considered acceptable for data analysis Data were normalized to percentage of inhibition of the biological response by using positive (that is lowest inhibition achieved in the absence of drug but in presence of the vehicle 0.5% DMSO ICtrl1) controls following the equation described below: where X is the inhibition of measured process for the compound X Ctrl1 and Ctrl2 are calculated as the average of replicates in the same microtiter plate where compound X is tested activity cut-off were calculated using templates in ActivityBase XE (IDBS Hit population analysis and visualization were conducted using Spotfire DecisionSite (Spotfire The pIC50 (−log IC50) values were obtained using the ActivityBase XE nonlinear regression function in the full curve analysis bundle The GSK TCAMS dataset for P. falciparum whole cell screening was deposited in ChEMBL-NTD, www.ebi.ac.uk/chemblntd. Additional chemical structures of compounds described in this study can be found in https://www.ebi.ac.uk/chembl/index.php/ The authors declare that all relevant data supporting the findings of this study are available within the article and its Supplementary Information files or are available from the authors on request Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen Publisher’s note: Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations World Health Organization. World Malaria Report 2015 http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/ (2015) World Health Organization. Global technical strategy for malaria 2016–2030 http://apps.who.int/iris/bitstream/10665/176712/1/9789241564991_eng.pdf (2015) A research agenda to underpin malaria eradication World Health Organization. WHO briefing on malaria treatment guidelines and artemisinin monotherapies http://www.who.int/malaria/publications/atoz/meeting_briefing19april.pdf (2006) Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria A randomized open-label trial of artesunate- sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P falciparum parasitaemia and gametocyte carriage in eastern Sudan Primaquine or other 8-aminoquinoline for reducing Plasmodium falciparum transmission In vitro activities of primaquine-schizonticide combinations on asexual blood stages and gametocytes of Plasmodium falciparum Primaquine to prevent transmission of falciparum malaria World Health Organization. Policy brief on single-dose primaquine as a gametocytocide in Plasmodium falciparum malaria http://www.who.int/malaria/publications/atoz/who_htm_gmp_2015.1.pdf (2015) Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa Combination therapies for malaria are failing—what next Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence ‘transmission blocking’ assay A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection A quantitative high throughput assay for identifying gametocytocidal compounds Identification of inhibitors of Plasmodium falciparum gametocyte development Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasites High-throughput assay and discovery of small molecules that interrupt malaria transmission Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs A novel multiple-stage antimalarial agent that inhibits protein synthesis Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation An Introduction to Chemoinformatics 21–24Springer (2007) A new in vivo screening paradigm to accelerate antimalarial drug discovery An invitation to open innovation in malaria drug discovery: 47 quality starting points from the TCAMS Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS) and multiple losses of tyrosine kinases in eukaryotes Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum Genome-wide detection of serpentine receptor-like proteins in malaria parasites Human malaria parasites in continuous culture Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes Download references This work was supported by Bill and Melinda Gates Foundation grant OPP1043501 We thank Richard Priest from Biological Sciences at GSK (Stevenage UK) for the production and conjugation of anti-Pfs25 antibody We also thank the GSK Sample Management Technologies team for the preparation of compound pre-dispensed 384-well plates we are grateful to Dr David Calvo and Juliana Sanchez for the culture and maintenance of An stephensi colonies used to perform SMFA experiments Naomi Richardson of Magenta Communications Ltd provided editorial assistance with the manuscript Dr Jake Baum is supported by an Investigator Award from the Wellcome Trust (100993/Z/13/Z) Present address: Present address: Mahidol-Oxford Tropical Medicine Research Unit Thailand and Centre for Tropical Medicine and Global Health biological profiling and contributed to data analysis performed data analysis of primary screening performed the cheminformatic analysis after each screening step performed the computational and chemical clustering performed the SMFA experiments and data analysis contributed to define the different biological profiles of hits wrote different sections of the manuscript and/or prepared figures and tables integrated individual contributions and issued the final manuscript All authors reviewed the manuscript and accept responsibility for its publication The authors declare no competing financial interests Supplementary Note and Supplementary References (PDF 574 kb) Biological properties of the 405 TCAMS confirmed hits in the Pf FGAA screen (XLSX 70 kb) Chemical clustering of the 308 prioritized TCAMS compounds (XLSX 26 kb) Biological data of the 90 compounds profiled in the Pf FGAA using different incubation times (XLSX 64 kb) Download citation a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science A sad day in Madrid at the Tanatorio de la Paz-Tres Cantos where on Friday Marcos Alonso Peña former FC Barcelona player between 1982 and 1987 and father of current player Marcos Alonso member of the Presidency Cabinet Enric Masip director of youth football José Ramon Alexanko and president of the Barça Veterans Juan Manuel Asensi represented FC Barcelona in the final farewell to Marcos Alonso Joan Laporta recalled that Marcos Alonso Peña "gave many moments of glory to the Club in a great era in Barça history." The president described the former player as a man with "character who always had affectionate words for Barça." Laporta added that Alonso was able to fulfil two of his great wishes before passing away "seeing his son play for Barça and getting to know his granddaughter."  Azora launches the Quetta Data Centers platform to invest more than 500 million euros in the construction of a network of 6 highly efficient “Edge” data centers in Spain and Portugal the portfolio’s data capacity will exceed 60 MW and will utilize 100% renewable energy to create [Iberia’s] first eco-efficient network of data centers with a PUE (Power Usage Effectiveness) rating of less than 1.15 Edge data centers represent a new category of data centers that are characterized by offering technological solutions to companies that require low latency in data processing and transmission These data centers are located near large urban centers in order to reduce data traffic with large hyperscale data centers which are usually located at a considerable distance from end users This investment marks Azora’s entry into the Iberian data center sector based on the conviction that this asset class will experience strong growth in demand in the coming years driven by supportive structural tailwinds and an acceleration in how businesses and society consumes data The six assets are predominately located in Madrid enabling Azora to take advantage of the excellent local market opportunity driven by the peninsula’s geolocation and proximity to wider communication infrastructure including intercontinental submarine cables Quetta’s target customers are companies with high data traffic very low delay times in the transmission of information packets Quetta will utilize a team with more than 20 years of experience in the sector alongside evolving technologies that can help to address new environmental challengesin the data centers sector and is in advanced stages of negotiations to complete the acquisition of the land and the contracting of the construction of the centers infrastructure and sustainability investments at Azora: “The launch of Quetta is part of our strategy of investing in sustainable infrastructure internet of things and other technologies such as artificial intelligence that will experience strong growth as the speed at which society and business consumes data accelerates This investment marks our first entry into the Iberian data centers market an asset class in which we hold a strong conviction and utilizes our deep expertise in both the local real estate market and in developing and owning operationally intensive assets.” founding partner of Core Capital and CEO of Quetta commented: “Quetta Data Centers seamlessly complements the current offerings in the Data Center market leveraging the excellent conditions of the Iberian Peninsula.” Y"},"category":false,"taxonomy":{"active":false,"name":"category"}},"markup":{"custom_html":true,"wpp-start":"","wpp-end":"<\/ul>","title-start":"","title-end":"<\/h2>","post-html":"{thumb} {title} {stats}<\/span>{excerpt}<\/p><\/li>"},"theme":{"name":""}} Bottom row left to right: Kosti Rautiainen EVP Customers and New Ventures at Caruna and Eyjólfur Magnús Kristinsson CEO atNorth Standing up from left to right Tommi Martikainen LiquidStack has opened a second manufacturing facility in Carrollton Texas to meet growing customer demand for its liquid cooling solutions Located just two blocks from LiquidStack’s headquarters and manufacturing site in the Dallas-Fort Worth Metroplex a leading provider of next-generation fiber solutions announces its presence at the Lost River Data Center the largest third-party Data Center in Southern Kentucky The Lost River Data Center is a joint venture between the WKU Research Foundation and Generac introduced a full lineup of five new generators designed for the data center market Generac Holdings lay bare its portfolio with new generators designed for the data center market These new products round out its energy solutions portfolio Twenty community groups across Stockport have been awarded a total of £30,000 in funding from the first-ever Kao SEED Fund which is developing a £350m data centre in Stockport charities and not-for-profit organisations from © 2025 Copyright © Digital Infra Network Ltd Vertiv (NYSE: VRT) brings together hardware analytics and ongoing services to enable its customers’ vital applications to run continuously perform optimally and grow with their business needs Vertiv solves the most important challenges facing today’s data centers communication networks and commercial and industrial facilities with a portfolio of power cooling and IT infrastructure solutions and services that extends from the cloud to the edge of the network Vertiv does business in more than 130 countries and for the latest news and content from Vertiv We are the first next generation Internet carrier Stelia is redefining the digital landscape with a native elastic connectivity platform that supports the burgeoning ecosystem of emerging Internet workloads High-capacity Wide Area Networking is more than a crucial piece of the puzzle – up until now it’s been the weakest link Stelia enables the transition to a new distributed data architecture data-intensive demands of the new breed of many-to-many workloads Whilst building Internet 3.0 by expanding into 600 sites across 30 countries in 3-5 years we’re creating more than a new backbone – we’re building a community on top of a software-defined network asset and we’re at the forefront of this change This is your invite to join us in this transformative journey to be a part of reshaping connectivity and leading the digital future VIRTUS Data Centres (VIRTUS) is a trusted global leader in the data centre industry and the UK’s leading data centre company resilient and responsible digital infrastructure for our customers As part of ST Telemedia Global Data Centres (STT GDC) VIRTUS Europe is the home of the cloud in London the STT GDC Group operates across Singapore providing businesses an exceptional foundation that is built for their growth anywhere Macquarie Asset Management acquired a significant minority stake in VIRTUS via Macquarie European Infrastructure Fund 7 Macquarie Asset Management is a global asset manager providing access to specialist investment expertise across a range of capabilities including infrastructure VIRTUS has a proven track record of over a decade designing and operating the UK’s most efficient facilities Committed to the highest standards of Operational Excellence – safety security and availability – VIRTUS hires the best people to work in an industry which is increasingly essential to everyone and everything We are laser focused on responsibly delivering solutions for the benefit of our customers Accelsius empowers mission-critical data centres to meet their business and sustainability goals through next-generation cooling systems The Accelsius NeuCool™ platform delivers a patented direct-to-chip two-phase cooling technology with best-in-class thermal efficiencies safe dielectric fluid & intelligent monitoring to provide a risk-free technology that scales from a single rack to an entire data centre NeuCool technology combined with Accelsius’ robust professional services program gives data center operators the confidence to evolve cooling approaches while ensuring performance improvements & continued uptime SOCOMEC is an independent industrial group with a workforce of 3900 experts spread over 30 subsidiaries in the world control and safety of low voltage electrical networks serving our customers’ power performance pioneering the development and operation of UK and European data centres engineered for AI and advanced computing With a hyperscale-inspired and industrial scale platform scalable and sustainable home for their compute Look out for your first newsletter in your inbox soon We help you navigate a myriad of possibilities Sign up for our newsletter for the best of the city By entering your email address you agree to our Terms of Use and Privacy Policy and 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Madrid The Tres Cantos fairgrounds are next to the central park and big lake They lay host to loads of events and activities For the last few years it's been the place for the Organic Roots Festival Thanks for subscribing! Look out for your first newsletter in your inbox soon! facebooktwitterspotifytiktokAbout us Contact us Time Out Worldwide has the highest income and the lowest unemployment in the country according to a new report published by the National Institute of Statistics which shows a clear division between living conditions in the north and south of Spain the average annual income was 26,367 euros in 2019 way above that of Boadilla del Monte (Madrid) at 21,976 euros and Sant Cugat del Valles (Barcelona) the average income in Pozuelo de Alarcón did drop by nearly 2,000 euros a year compared with the previous year unlike the other two towns where it increased slightly two are in Barcelona province and two in the Basque Country In all of these the net average income is above 18,000 euros per inhabitant considerably higher than the national average The statistics refer to towns with more than 20,000 inhabitants and at the other end of the scale are Níjar (Almeria) These are all in the same place as last year The other towns at the bottom of the list are Barbate (Cadiz) Sanlúcar de Barrameda (Cadiz) and Torrevieja (Alicante) Unemployment figures for Spain in 2021 show that the lowest levels were in Pozuelo de Alarcón (6.2%) Majadahonda (7.4%) and Donostia/San Sebastián (7.8%) The highest unemployment was found to be in Linares (30.9%) Jerez de la Frontera (26.0%) and Santa Lucía de Tirajana (26.0%) Comentar es una ventaja exclusiva para registrados as one would expect from its ornate costumes and historical backdrop About 60% of the show was shot at Netflix's Tres Cantos production center in Madrid The other 40% of the shoot was done on location in different areas of Madrid and Barcelona Although the action occurred in Madrid in 1871 the series does not use available historical locations or Georgian properties for its setting bespoke sets were designed to portray the period and settings required for the narrative Although the series has an 18th-century feel with a focus on the aristocracy the filming did not involve heritage mansions or period architecture that exists in Britain the production team recreated extravagant indoor environments inside sound stages to convey the social and cultural atmosphere of Spain in the late 19th century Shooting mostly within studios gave more creative control in the representation of the era with outside locations in Spain serving only as shots required to deliver the feel of the period The interior scenes of The Lady's Companion were filmed at Netflix's Tres Cantos studio campus The studio campus boasts several sound stages with the most advanced filming equipment Shooting within the contained studio environment the production crew could construct sets from the ground up modifying each aspect to fit the 1871 Madrid setting of the series Perhaps the most crucial set constructed was the one for the Mencia family—a standout location in the series The home was designed to meet the tastes and élan of late 19th-century upper-middle-class Spanish society Although the series occurred decades before the golden age of Georgian architecture production designers incorporated aspects such as grand staircases and lavish woodwork to induce an aura of grandeur and potency appropriate to the characters These settings were not based on real homes but rather created as stylized versions to suit the tone and direction of the show there were some exterior scenes shot on location in Madrid and Barcelona Locations provided genuine city textures that enhanced the show's realism and building facades visually similar to what Madrid would have appeared during the 19th century shooting likely happened at locations preserved with historical particulars providing adequate imagery for streetscapes locations that had period structures and cobblestone roads were employed to recreate the ambiance of the era The blend of studio-created locations and actual locations enabled the production to meet the demands of visual narrative control with authenticity through genuine Spanish structures Rather than filming inside historical houses or museums The Lady's Companion adopted a policy of controlled and stylized depiction the producers were free to emulate the distinctive look of the late 1800s while not compromising on cinematography versatility and other interior home spaces designed with period reference in mind but built for functionality in contemporary shooting The art team worked with historical consultants and set designers to ensure that while the setting was fictional and furnishings were chosen to recreate 19th-century Madrid even if they were not direct copies from actual places It should be mentioned that The Lady's Companion breaks the traditional structure of British period drama In contrast to being structured around royalty or highly recognized events the series is based around lesser recognized characters that were in Madrid in 1871 The series adds a bit of humor in the genre with a tone difference compared to serious period pieces This tone discrepancy translates into set and filming styles as well where character development is more of a priority over re-creating scenes of historical events The use of studio sets and urban Spanish locations serves to underpin this narrative trajectory The flexibility afforded by tailor-made environments makes possible a wider range of scene construction—be it in the guise of witty repartee in sumptuous halls or quiet personal moments in intimate chambers Also read: Netflix to end period drama The Empress with a third and final season Pride and Prejudice spinoff: BBC greenlights new period drama titled The Other Bennet Sister Your perspective matters!Start the conversation We were given the opportunity to visit Netflix’s big production hub just north of Madrid in Spain and tour several of its big sound stages Here’s what we learned about the new series due out later in 2024 Showrunner Carlos Montero was on hand to guide us through the massive two-floored hospital set which takes up one of the ten sound stages at the 22,000-meter squared complex making it the largest in the European Union He is best known for his long-running Netflix series Elite Other released projects include The Mess You Leave Behind Talking about the show’s inception and themes Ávalos and Montero said the major themes throughout the series would encapsulate life That’s why they deliberately chose Valencia as the story’s location clinical environment of a hospital with the picturesque and bright Mediterranean atmosphere The series follows the lives of doctors and residents at the chaotic and extremely busy public fictional Joaquín Sorolla Hospital in Valencia and the showrunner was keen to point this out throughout the tour but moving walls allow certain rooms to be transformed depending on the script’s needs Small details like patients’ names on waiting lists posters with Spanish and Valencian languages and genuine labeling on bottles and medicines in cabinets create an immersive place to visit If even half of that is translated on screen which took six months to construct from inception he noticed everything was too clean and pristine and not what a working hospital would look like you can see scuffs on the floor where hospital trolleys would be used and other things that give the impression of a lived-in and used hospital space Alfonso Bassave as Lluís in episode 02 of RESPIRA This importance to detail is particularly important with a series like Respira takes place within the confines of the hospital walls 80% of the show was filmed on this sound stage with the other 20% taking place on location in Valencia The attention to detail goes beyond set details The series employed real doctors as consultants to ensure medical accuracy They also designed the space to be chaotic and that’s reflected in the number of staff and patients seen on screen Another detail the creator emphasized while guiding us around was the use of color in the hospital “We worked a lot on the colors,” Montero said through a translator “We put the red chairs to convey the feeling of uncomfort.” Borja Luna as Nestor in episode 05 of RESPIRA Tanz and Ávalos suggested that the show is a big bet for Netflix and hopes to run for multiple seasons Ávalos said the show had come together better than they envisioned when they first read the scripts and suggested they’re confident it’ll hit in Spain and the rest of the world Ávalos teased that development is already ongoing for more “[Carlos] is already halfway through writing season two so we’re way ahead of where we want to be because we believe so much in the series.” Manu Ríos as Biel in episode 01 of RESPIRA Ávalos expressed excitement for the upcoming release of Breathless and said Montero is always a creator who prioritizes the audience in his storytelling A new 8-episode series, Legado, entered production earlier this year and has been dubbed a “family saga drama” in the tour It was also teased that Montero wouldn’t leave the Netflix stable anytime soon he actually has to get approval from me.” That’s all for this write-up about the visit to Netflix’s Tres Cantos studios; we’ll have more to come throughout the remainder of this week Kasey Moore is the founder and editor-in-chief of What's on Netflix the leading independent resource covering Netflix with over a decade of hands-on experience tracking Netflix’s new releases His reporting and data insights have been featured in leading publications including Variety K-Dramas New ‘Squid Game’ Season 3 Teaser and First Looks Drop; Teases First New Game Coming Soon to Netflix What’s Coming to Netflix This Week: May 5th to 11th, 2025 Netflix News Netflix Developing Sam Bankman-Fried FTX Biopic Series With Oscar-Winning Writer Graham Moore What's New on Netflix New Movies & Series on Netflix This Week & Top 10s: May 2nd, 2025 Stranger Things Season 5: What You Need To Know About The Final Season & TUDUM Details Leaving Soon from Netflix What’s Leaving Netflix in June 2025 WWE / Coming Soon to Netflix WWE RAW, SmackDown, NXT Netflix Live Schedule for June 2025 Netflix News / What To Watch on Netflix Emmys 2025: All the Netflix Series and Film Hopefuls Tom Segura’s ‘Bad Thoughts’ on Netflix: May 2025 Release & What We Know What To Watch on Netflix The 10 Best Original Sitcoms on Netflix in 2025 What’s Coming to Netflix in May 2025 Netflix Renewals 2025: Every Show Coming Back For New Seasons What's New on Netflix United Kingdom (UK) What’s New on Netflix UK This Week: Netflix’s ‘The Four Seasons’, ‘Mean Girls’ & ‘Black Adam’ All 145 Movies and TV Series Blocked On Netflix’s Advertising Tier (May 2025) Was ‘Spellbound’ a Disappointment For Netflix And Is ‘Cocomelon’ Losing Its Crown? alongside journalists from major Hollywood trades and local journalists from across Europe to tour the production facilities Netflix has at Tres Cantos I wanted to get into the rest of everything else I learned from the tour The tour was primarily helmed by Larry Tanz (VP of Content EMEA) and Victor Marti Farres (Director of Production and Post-Production Diego Ávalos and Victor Marti Farres – Netflix The production hub is approaching its fifth anniversary and has been the home to some massive productions over the years. Society of the Snow is perhaps the latest example of taking full advantage of modern and advanced facilities Other shows filmed here include Money Heist The facility is the biggest filming location in the European Union each with “complementary facilities including storage and office spaces and make-up and hair areas.” For post-production This production hub’s design essentially allows a show or movie to go through every stage of its life without ever needing to interact with the so-called Los Angeles or Los Gatos motherships “Álex Pina talks about having to fly to LA to pitch a show so that he could make a show in Spain having to figure out a way to break into Hollywood just so that they could realize a creative vision.” “Fast-forward to today,” Tanz continued We have full teams in those different countries: creative production finance—everything that you would have in a studio operation And they’re working with local talent.” Tanz and Ávalos cited this way of working as the blueprint rolled out across Europe and the world This more efficient approach ensures authenticity and resonance with local audiences Despite primarily focusing on local content, the readiness to lend support extends to productions outside Spain. The Mother, Warrior Nun, The Crown, and the upcoming Jeff Goldblum series Kaos were cited in filming in Spain with American and British teams helming them Kaos is one of the shows shot in Spain – Picture: Netflix The post-production facilities on site are where the hub is most plugged into Netflix’s global infrastructure They host new technologies that have been pioneered and tested here first they use Netflix’s cloud-based remote solutions throughout enabling editors to work collaboratively across different locations and time zones This innovation is particularly showcased with one example cited by Farres “We have a show that is being edited between editors in Mexico all together connected to that data center that we have here.” the tools bring creators efficiency and flexibility He cited another example of a Portuguese series which utilized the facility’s capacity to handle extremely large data volumes (two terabytes per day) which can be edited on and worked with the day after the shoot by editors based in Lisbon Part of the tour allowed us to go into the edit bay to see how one editor was working on a TV show using this technology We saw him scrubbing through footage in spectacular quality and pulling through clips instantaneously he’d be able to save his work here and pick up right where he left off at home Tanz stated that what Netflix has at Tres Cantos are “world-class post-production facilities,” adding “Having spent 20 years in Hollywood and Warner Brothers and Universal and Sony stages even a level above because they’re new with all soundproofing and modernization that some of those stages don’t have and these are on par or ahead of the top stages in Hollywood.” Development on these tools isn’t just made in Los Gatos either Farres told me they have engineers onsite to troubleshoot and implement solutions for specific shows or movies on their slate During a roundtable with both Tanz and Ávalos the duo was asked about whether they’re scaling back their output from Spain or “Our members really love local films and series,” Tanz said adding that variety is key to success serving 270 million households adding that “no entertainment company has tried to program that breadth and with that ambition.” “We have not reduced at all,” said Ávalos “If we see a new opportunity that we want to pursue we pursue that opportunity to make sure that our members are getting the entertainment and satisfaction that they’re looking for from an entertainment company like ours.” suggesting that acquiring films is just as efficient as making them film is super central to what we do,” Ávalos said “They [Netflix subscribers] don’t differentiate where a great film is coming from whether it originated within Netflix or elsewhere.” Tanz suggested that it’s more “meaningful” to premiere series on Netflix rather than films “Following something that’s already been on TV is less special than following something that was just in the theatre.” Netflix cited its partnerships with European studios and distributors to enhance its film library through pay-one licensing windows or other collaborations Examples included deals with Constantin Film in Germany These collaborations allow Netflix to finance and acquire high-quality films benefiting both the creators and Netflix’s members Society of the Snow – Picture: Netflix The final of the three set visits involved getting a demo of the virtual sound stage (sometimes referred to as The Volume) it’s a set with a large panel of LEDs that can be wrapped around it to give the appearance of being in a particular location It is very impressive to see this up close and in the context of a scene being filmed where it can adjust. The Mandalorian is perhaps the most famous example of a show using this technology Netflix has been using it in various locations for a while now with Avatar: The Last Airbender and 1899 being the two biggest examples The tour suggested that many productions are taking advantage of this technology with driving scenes being cited as one of the main ways shows utilize it We also saw multiple takes of an upcoming show that was done live while visiting. While I’m not allowed to discuss what I saw in detail, we can say it was filming for The Fallout Shelter and looked like a signature Pina show I couldn’t find some of the other international journalists present That’s all I have to say about my trip to Tres Cantos