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HOUSTON -- Golden State guard Gary Payton II won't play in Game 7 of the first-round playoff series Sunday night against the Houston Rockets because of an illness
Warriors coach Steve Kerr provided details on how Payton was doing before the game
Payton came off the bench in the first five games of the series before starting Game 6
He had 16 points in Golden State's 104-93 win in Game 3
Kerr was asked how Payton's illness will impact the team's rotations Sunday night
"He's obviously been an important player for us in the series
So we're actually going through it right now and trying to figure out lineup combos
But it definitely opens up the door for more minutes for several different options
the Warriors will be unexpectedly down a player
If the Golden State Warriors are going to keep their season alive with a Game 7 victory over the Houston Rockets on Sunday, they will have to do so without one of their best defensive players. Warriors wing Gary Payton II has been ruled out for Game 7 with an illness, per a report Dalton Johnson of NBC Sports Bay Area
was added to the injury report and listed as questionable earlier in the day
It seems he has been unable to recover in time to play
Gary Payton II is now OUT tonight for Game 7 because of an illness @NBCSWarriors
This is the third time this series that a Warriors player has been sidelined by an unexpected ailment in Houston
Brandin Podziemski was seriously limited in Game 2 against the Rockets by an infection that caused severe gastrointestinal problems
He only played 14 minutes and was abysmal on the floor
Jonathan Kuminga was out for Game 5 with a migraine that popped up on the day of the game
Payton is a dominant on-ball defender on the perimeter and an excellent slasher
While a scorching hot shooting stretch earlier in the season was cut short by an injury
he has remained a key rotation piece when healthy
Payton has averaged 6.5 points and 3.0 rebounds per game on 57.4% shooting from the field (32.6% from three) shooting
Payton has averaged 6.3 points and 2.3 rebounds per game on 50% shooting from the field (40% from three)
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A 3,300-year-old Egyptian obelisk looming over Paris’ Place de la Concorde recently yielded a sequence of secret messages
all thanks to French Egyptologist Jean-Guillaume Olette-Pelletier’s keen observations
Once placed at the Luxor Temple’s entrance in Egypt
the red granite monument is now the target of a groundbreaking study that claims it was an ancient propaganda monument promoting Pharaoh Ramesses II as a divine ruler
Originally constructed by Ramesses II—one of the most prolific builders of ancient Egypt—the obelisk was gifted to France by the Ottoman Empire in the early 19th century and relocated in 1836
it had been admired for its aesthetic and historical significance
who teaches at the Sorbonne and the Catholic University of Paris
the carvings conceal more than meets the eye
During his regular walks around the obelisk
Olette-Pelletier began noticing unusual patterns within the hieroglyphs
I realized something unusual: The hieroglyphs’ meaning indicated a direction
that of the entrance to the portico of the Luxor Temple,” he told Sciences et Avenir
Curious and unable to find previous research on the subject
when scaffolding covered the obelisk for restoration ahead of the Olympic Games
Olette-Pelletier climbed the scaffolding to examine the upper parts—usually inaccessible to researchers
The close inspection confirmed that the monument carries a total of seven crypto-hieroglyphs—a rare form of encoded text discovered in the 1950s by Canon Étienne Drioton
were meant only to be understood by Egypt’s intellectual elite
would have been legible to nobles arriving by boat on the Nile
especially to those attending an annual Opet Festival honoring the god Amun
The side of the obelisk that once faced the river (now the Seine) was built so carefully that only from specific angles were the inscriptions readable—including one that even needed to be viewed from a 45-degree angle
One of the inscriptions contains a depiction of Ramesses II presenting offerings to Amun
with inscribed text declaring the divine origin and eternal right to rule of the king
One striking example of this three-dimensional cryptography is an engraving that
spells out Ramesses II’s full throne name
shows an offering table beneath the god Amun
completing a sentence that reads as a sacred offering from the king to the deity
Though the discovery has caused excitement
Olette-Pelletier’s findings not only shed light on how the ancient Egyptians used monumental art for ideological purposes but also on how rulers like Ramesses II upheld power by controlling public imagery
His full findings are expected to be published in the Egyptology journal ENiM
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Looks can be deceiving. This monstrous Mercedes might look like an original 190E EVO II but, under the skin, it's altogether different.
First, a little bit of history. The EVO II arrived as a final-throw-of-the-dice homologation special in 1990, and finally gave Merc a DTM title in 1992. With its striking aero kit and Cosworth 2.5-litre engine making 232bhp in road-going trim, the EVO II is a Mercedes icon. Not to mention it's one of the coolest cars ever built. Naturally, that makes original EVO IIs really quite rare, and really quite expensive.
So, enter Dom Tucci, an Industrial Designer at Tucci Hot Rods. With an original EVO II out of reach, he decided to use the learnings from his hot rod shop to build a personal tribute. Check it out above in the latest episode of American Tuned with Top Gear’s tuning correspondent Rob Dahm.
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Tasked by UAE Team Emirates with making the world’s fastest rider – Tadej Pogacar – even faster against the clock
MET has invested in building its own wind tunnel in Talamona Italy
the wind tunnel is being used for MET’s testing and development
The first major release from this venture is the Drone Wide Body II time trial helmet
Engineered specifically for cycling aerodynamic and thermal analysis, MET’s proprietary wind tunnel is a state-of-the-art facility for testing helmets, bikes, rider positions
testing different shapes and configurations is key to finding the perfect balance for a variety of riders’ bodies and positions
MET can evaluate multiple solutions in the Tube and fine-tune the design
MET developed the Tube to conduct two modes of testing
one using just the headform to analyze the aerodynamics of a helmet on its own
and another holistic testing setup with the bike and rider
This allows MET to evaluate not only the helmet shape but also how the helmet interacts with the rider and the whole system of rider and bike
The Tube is the latest addition to MET’s Italian HQ in Talamona
completing what is now the most advanced helmet development facility in the world
This includes a crash test laboratory
and now an aerodynamic and thermal wind tunnel
The Tube is equipped with a headform that integrates thermal sensors around its entire crown
which simulates the temperature of the body under strain
MET engineers measure the temperature decrease over time to test air flow; the faster it decreases
the more effectively the internal air channeling is functioning
“the Drone Wide Body II is the second generation of the helmet that has won multiple World Tour Time Trials and Ironman World Championships
helps the new Drone II be 13.5 seconds faster over a 40 km time trial than the previous version
The linear tail design allows for a lower head position while riding.”
The MET Drone’s unique wide body design channels airflow over the shoulders
significantly reducing turbulence and drag
This results in valuable energy savings and an aerodynamic advantage for the rider
The low drag inlets are strategically positioned to reduce air turbulence and are working with an internal air channeling system to improve ventilation and comfort
it’s among the lightest long-tail helmets on the market
offering superior comfort on a long-distance Ironman race
Other key features include an in-mould polycarbonate shell with EPS liner
360° head belt with vertical and occipital adjustments
The Drone Wide Body II retails for $566 US
met-helmets.com
and loves to explore the backroads and mountain passes of the Pacific Northwest on skinny tires
Working in various roles across the bike industry since 2008 has given Bennett a broad and deep understanding of cycling gear and tech
Bennett still holds onto an irrational love of rim brakes
He’s lost count of how many bikes he’s owned but continues to swear up and down that his next bike will be his last
Everesting three times and racking up 1M feet of vertical in 2020
but still shaves his legs and rips down fast and twisty descents
especially if there’s craft beer near the bottom
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“ the new Drone II be 13.5 seconds faster over a 40 km time trial than the previous version.” so the old helmet slowed you 13 seconds !
but don’t want to deal with solvents
Simpyfast claims their Lube Cube is the easiest way
Peak Performance expands on their MTB specific clothing with new pants
We spotted Cofidis racing an all-new prototype wireless 13-speed Campagnolo Super Record 13 WRL SC road groupset
Canyon Bicycles is now selling select models directly through Amazon.com
Want wireless shifting but don’t want to have to buy a whole new drivetrain
Be protected from the sun with the new UV Hooded Trail Shirt… OrNot
The new Van Nicholas Astraeus is a beautiful titanium road bike that’s limited to just 50 frames
Etna in Sicily will host the first Everesting World Championships in Fall 2025
where individuals & teams attempt to summit by bike
Channelsreels-589465Reelsarrow-expand-589466Victor Scott II robs a home runMets @ CardinalsMay 4
2025 | 00:00:27add-reel-589467Reelsshare-square-2-589468ShareVictor Scott II leaps high at the wall to rob Juan Soto of a home run in the top of the 4th inning
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2025) – Chicago Fire FC II and MLS NEXT Pro today announced that the team has been named MLS NEXT Pro Team of Matchweek 8 following a resounding 5-1 victory over Orlando City B on Friday
After conceding an opening goal in the 29th minute
five different players tallied their first goal of the season in unanswered fashion to nab the victory for Chicago Fire II
Right back Peter Soudan tied the match in 37th minute
before Jason Shokalook tallied the eventual game-winner just five minutes later
Chicago then took over the match with goals from defenders Jean-Alpha Diouf and Justin Reynolds and forward Dean Boltz to complete the 5-1 victory in its first game at Flames Field
This marks the first time Chicago Fire II has earned a weekly honor
The 2024 side featured multiple individual awards
including the MLS NEXT Pro Most Valuable Player award for midfielder David Poreba and two MLS NEXT Pro Goalkeeper of the Month awards for Chicago Fire Academy goalkeeper Patrick Los
This also marks the first time Chicago Fire II has been named Team of the Matchweek since its inception in 2022
New York City FC II fell 4-2 to Inter Miami CF II in a hard-fought match in Florida
Goals from Chris Tiao and Máximo Carrizo weren’t enough
Despite City's persistent pressure and a second-half penalty
Cristian Ortiz's late goal sealed the win for the home side
with Yuval Cohen adding a fourth in injury time
A trip to the Sunshine State was the backdrop for New York City FC II as they took on Inter Miami CF II
Matt Pilkington’s side were looking for a positive outing on the road
as head coach Matt Pilkington opted to utilize a back-three system consisting of Max Murray
The early exchanges of the contest saw the hosts enjoy the lion's share of possession without converting that into clear chances
Máximo Carrizo played Julien Lacher in on the left-hand side of the penalty area
That began a sustained period of City pressure
as Lacher danced down the right to earn City a corner
Their sustained pressure paid off in the 22nd minute after fullbacks Drew Baiera and Chris Tiao combined to score
It was Baiera’s cross to the back post that found Tiao
Miami earned a free kick just after the half-hour mark
but the effort from distance was comfortably saved by Mac Learned
Zidane Yáñez found Seymour Reid just outside Miami’s box with a good pass
allowing the forward to fire off a shot that whistled just past the post
The hosts would find an equalizer just before halftime after a clipped pass was dinked over Learned by Alejo Ristano
Miami started the second half the brighter of the two sides and took the lead in the 53rd minute through Mateo Dulce
City did not dwell on the disappointment of falling behind
with Carrizo converting from 12 yards out to tie the game
Pilkington turned to his bench for the first time in the 69th minute to introduce Piero Elias in place of Yáñez
That was followed by a second change minutes later as Carrizo departed in place of Sebastiano Musu
The game was delicately balanced when Miami found a third through Cristian Ortiz in the 84th minute
They would add a fourth in injury time through Yuval Cohen
that would be the last goal of the evening and confirmed a 4-2 defeat for City on the road
Next up for New York City FC II is a Hudson River Derby meeting with Red Bulls on Friday
physical and productive back in the sixth round of the 2025 NFL Draft in Oklahoma State's Ollie Gordon II
Gordon II was the centerpiece of the Cowboys' offense that featured multiple run schemes
Gordon II fell in love with Miami and the Dolphins during his pre-draft visit
"As soon as I met (Head Coach Mike McDaniel) I fell in love with him
He told me the offense fits me and that I can help the offense."
One of the most accomplished running backs in college football since the moment he arrived in Stillwater
Gordon II leaves the Cowboys program with more than 3,500 career yards from scrimmage and a total of 40 touchdowns
which produced 1,732 rushing yards (led the nation
fourth most in program history) and 21 rushing touchdowns (sixth most in Oklahoma State history) brought home the Doak Walker Trophy
annually awarded to the nation's best running back
Four of the past five winners of the Doak Walker Award heard their names called in the top 40 picks of the NFL Draft
Bijan Robinson in 2022 and Ashton Jeanty in 2024
Kenneth Walker II won the award in 2021 and was selected in the second round the following April
vision and the ability to read blocks to find cutback lanes all pop off Gordon II's college tape
the power is obvious – his 68 missed tackles forced in 2023 were the most in college football
He also gained 1,056 yards after initial contact
second most in the NCAA behind North Carolina's Omarion Hampton
At a 96th percentile height for running backs
Gordon II's jumps (vertical and broad) and timed speeds all eclipsed the 60th percentile mark for running backs
evident by the 73 runs of 10-plus yards over a three-year career
Gordon II had 21 rushes that produced at least 20 yards
The quickest way for a rookie running back to carve out playing time is by offering third down value
Gordon II is a hammer in short yardage and has enough receiving chops (80 career receptions for 585 yards and four touchdowns) to keep defenses honest on the money down
but it's the work he does protecting his quarterback that stands out above the rest
Gordon II didn't allow a sack across 221 career pass blocking reps
On only in one occasion did he allow his quarterback to get hit by the defense
which is less than a half of a percentage point
He certainly harbors the right mindset when it comes to protecting his quarterback
I'm trying to take you out," Gordon II said
"That's going to be your last play blitzing; if I've got to cut you
that's going to be your last play blitzing
and I'm going to make you think about it."
and the rest of the Dolphins 2025 draft class
download the Drive Time Podcast with Travis Wingfield
The Dolphins make it two Terrapins in three picks adding safety Dante Trader Jr
returns to his hometown after fulfilling lifelong dream of being drafted by the Miami Dolphins
The NFL selected Miami Dolphins fan Lucas Rossetti as the 2024 NFL International Fan of the Year at the 2025 NFL Draft
The run on big guys continues as the Dolphins add another interior lineman on the defensive side in Maryland's Jordan Phillips
2025) – New England Revolution II (3-1-3; 15 pts.) dueled Toronto FC II (3-2-2; 11 pts.) to a 3-3 draw at York Lions Stadium on Sunday afternoon
claiming an additional point with the 9-8 penalty shootout victory
Red-hot forward Liam Butts tallied his fifth goal in as many games
while midfielder Gevork Diarbian posted a goal-and-assist performance
Brazilian forward Marcos Dias drew a penalty in the second half and converted to tally his third goal of the season
Revolution II extended their unbeaten streak to three games
collecting points in six of their seven matches to open the season
Revolution II currently ranks tied for second in MLS NEXT Pro with their 15 points on the year
Toronto found the scoresheet early in the match
with Marko Stojadinovic opening the scoring in just the fifth minute
with Butts slotting home a low shot behind Toronto's goalkeeper
Butts owns a team-best five goals on the year and is tied for the fourth-most goals scored in MLS NEXT Pro
New England claimed the lead in the 39th minute
with Diarbian netting his first goal of the season
The Providence College alum's initial shot was deflected by a Toronto defender
striking his second attempt off the right post and into the net
Diarbian led New England's attack with five shots
New England added another goal in the 49th minute
The Brazil international calmly converted from the spot for his third goal of the season
his sixth goal contribution in as many games
Toronto pulled one back in the 63rd minute and leveled the match in the 78th minute via a New England own goal
With defender Eli Ackerman and midfielder Ivan Villalobos Lopez earning their first minutes today
42 Revolution Academy products have now made their professional debuts with Revolution II
Fellow Academy player Grant Emerhi earned his first start with Revolution II today
while Academy midfielder Javaun Mussenden logged his first start of the 2025 campaign
16-year-old midfielder Judah Siqueira entered the match in the 76th minute
suiting up for his third appearance with New England
Revolution II are off next week and will return to action on Sunday, May 18 with a visit to the New York Red Bulls II at MSU Soccer Park. The match kicks off at 5:00 p.m. ET and is available to watch live on MLSNEXTPro.com
New England Revolution II: JD Gunn; Hesron Barry (Eli Ackerman 11'
Cristiano Oliveira (Ivan Villalobos Lopez 66')
Toronto FC II: Adisa De Rosario; Stefan Kapor (Ythallo 63')
Patrick McDonald (Micah Chisholm 63'); Nate Edwards
Malik Henry (Constantinos Illiadis 63'); Jahmarie Nolan (Josh Nugent 72')
Bangkok hosted another action-packed lineup inside Lumpinee Stadium with ONE Fight Night 31: Kongthoranee vs. Nong-O II in U.S
At the helm of it all were two of Thailand’s favorite sons, as Kongthoranee Sor Sommai and Nong-O Hama duked it out in a sensational flyweight Muay Thai rematch.
The delectable action delivered a card worth remembering and also left fans with plenty to think about.
As 2025 rolls on, these are five takeaways from another exciting event inside one of the most storied venues in martial arts.
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Life at flyweight is looking good for Nong-O.
He entered the ring for his rematch against Kongthoranee appearing fit, fresh, and determined. And the result was a dazzling performance, albeit with some adversity, to notch a unanimous decision victory.
The Thai legend did not look 38 years of age. He was sharp and quick, firing his piston-like punches toward the face of Kongthoranee.
He even answered the question of whether he could still take hard shots, eating a Kongthoranee punch in the second frame that briefly had him wobbled. The survival instincts were just as impressive as his pristine technique.
With a huge win over the #3-ranked contender, Nong-O is right in the thick of the race for the vacant ONE Flyweight Muay Thai World Title. What a story it would be if he could punch his ticket and challenge for the crown.
In one of the most talent-rich divisions in all of combat sports, having Nong-O on the doorstep of another World Championship fight is a thrilling proposition. And every fellow contender would present a mouth-watering matchup.
View this post on Instagram A post shared by ONE Championship (@onechampionship)
American sensation Tye Ruotolo successfully defended the ONE Welterweight Submission Grappling World Title against Canadian powerhouse Dante Leon in a competitive trilogy match
it was not just Ruotolo’s defense that grabbed attention – it was what he said after putting the 26 pounds of gold back over his shoulder
The Atos BJJ representative confirmed that he is still looking to make a transition into MMA, just like his twin brother, Kade Ruotolo
And given Kade’s early success in the all-around sport
Tye could be an immediate factor in the welterweight division
Kade has been perfect since moving into MMA and flashed his stand-up abilities in his last outing at ONE 171: Qatar before earning his third consecutive submission win. Tye has all of the tools to have an equal impact.
The 22-year-old Ruotolos have dominated the submission grappling scene for years, and Tye could make waves by chasing two-sport gold himself.
View this post on Instagram A post shared by ONE Championship (@onechampionship)
Who is Abolfazl Alipourandi? That was what many were asking when the Iranian accepted a short-notice opportunity to meet British fan favorite Liam Nolan in a lightweight Muay Thai matchup.
Just 59 seconds into the match, Alipourandi provided the answer with a stunning head-kick knockout.
Careers are built upon moments that come in fractions of a second when a window of opportunity opens. Alipourandi had full belief that he could compete against someone of Nolan’s caliber – and he showed out.
The Team Mehdi Zatout athlete will need to continue capturing those moments as he eyes bigger goals among the division’s elite. From obscurity to ONE Fight Night 31 glory and international acclaim, Alipourandi has arrived.
View this post on Instagram A post shared by ONE Championship (@onechampionship)
ONE Friday Fights may be the most exciting weekly martial arts event series on the planet
but it also develops the next crop of top talent for the organization’s main roster
That was evident at ONE Fight Night 31 with young phenoms Akif Guluzada, Abdulla Dayakaev, and Lucas Gabriel all picking up key wins
Dayakaev might have crashed the ONE Bantamweight Muay Thai World Title discussion with a second-round TKO over former World Title challenger Saemapetch Fairtex. Meanwhile, Guluzada and Gabriel dispatched Sean Climaco and Zhang Lipeng, respectively, with dominant unanimous decisions.
The performances from these upstarts are continuous proof that ONE Friday Fights is the gateway to achieving greatness. The next era of elite martial artists is being built on Fridays in Asia primetime at Lumpinee Stadium.
View this post on Instagram A post shared by ONE Championship (@onechampionship)
Top-five contender Johan Estupinan has taken the flyweight Muay Thai division by storm with pizazz and show-stopping results. Many questioned whether his twin brother, Jordan Estupinan
could replicate that kind of impact in the world’s largest martial arts organization
Following a standout unanimous decision over Ali Saldoev at ONE Fight Night 31
Call it twin magic or anything else you want – the Estupinan brothers are showing they are special
A combined 7-0 record in ONE has displayed their incredible skill sets
establishing a new standard for South American strikers
Johan has already kicked the door down on the flyweight rankings
and Jordan has announced his presence in a major way
Their talent and star power are redefining an era for an entire region while establishing themselves as undeniable forces
Maryville and defending national champion Tampa earned the top four seeds as the NCAA unveiled its largest-ever Division II women's lacrosse championship bracket Sunday evening
The expanded 24-team bracket features six teams selected from each of the four geographic regions and included
automatic qualifiers that won league championships
The top two seeds in each region received first-round byes and are serving as host sites for NCAA first- and second-round games
Winners of second-round games on May 10 will advance to the national quarterfinals on May 17
The four quarterfinal winners (regional champions) will then be re-seeded for the national semifinals on May 22 in Salem
Seven teams earned their first-ever NCAA tournament berths: Ashland
(5) Limestone (14-5) (3) East Stroudsburg (14-5) vs
Anselm (12-6)(3) Dominican (N.Y.) (18-1) vs
(5) Rockhurst (14-4) (3) Regis (13-4) vs
(5) Flagler (13-5)(3) Embry-Riddle (16-3) vs
USA Lacrosse is a 501(c)3 tax-exempt charitable organization (EIN 52-1765246)
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Philippines — A World War II-era Philippine navy ship to be used as a target in a combat exercise by American and the Philippine forces accidentally sank Monday hours before the mock assault
The BRP Miguel Malvar, which was decommissioned by the Philippine navy in 2021, took on water while being towed in rough waters facing the disputed South China Sea and sank about 30 nautical miles (55 kilometers) off the western Philippine province of Zambales
Nobody was onboard when the ship listed then sank
American and Philippine forces would proceed with other live-fire maneuvers off Zambales on Monday despite the premature sinking of the Malvar
The ship was built as a patrol vessel for the U.S
Navy in the 1940s and was transferred to Vietnam’s navy before the Philippine military acquired it
"It’s an 80-year-old dilapidated ship and it wasn’t able to withstand the rough seas,” Philippine Lt
John Paul Salgado told The Associated Press
The ship-sinking exercise was planned in an offshore area facing the hotly disputed Scarborough Shoal
which has been closely guarded by the Chinese coast guard
The Philippines also claims the fishing atoll, which lies about 220 kilometers (137 miles) west of Zambales. Chinese and the Philippine forces have had increasingly hostile confrontations in the waters and airspace of Scarborough in recent years
The cancelled ship-sinking drill would have been the third to be staged by the treaty allies in recent years
It was supposed to be one of the highlights of largescale annual military exercises by the United States and the Philippines from April 21 to May 9 with about 14,000 U.S
the combat drills have increasingly focused on the defense of Philippine sovereignty in the face of China’s growing aggression in the South China Sea
which Beijing claims virtually in its entirety
Mock battle scenes which have been staged so far, including the retaking of an island from hostile forces, have reflected assurances by the Trump administration, including by Defense Secretary Pete Hegseth
would abide by its treaty commitment to defend the Philippines in case Filipino forces come under an armed attack
Australian and Philippine forces practiced retaking an island from hostile forces in the coastal town of Balabac in western Palawan province
Japanese forces and British marines joined as observers of the combat exercise
which “showcased the growing interoperability and cohesion among partner nations in maintaining regional security,” Salgado said
"What we have seen since Trump returned to the White House is a remarkable level of continuity in the US-Philippines alliance not only in joint military drills
but also on American statements that the alliance is ‘ironclad,’ said Derek Grossman
a senior defense analyst at RAND Corporation
“The Trump administration is trying to keep the pressure on China through its support to the Philippines," Grossman said
but added that it’s unclear “just how sustainable this commitment will be given that the Trump administration seems less hawkish on China than its predecessors.”
China has vehemently opposed such exercises involving U.S
forces in or near the South China Sea or Taiwan
which Beijing claims as a province and has threatened to annex by force if necessary
have insisted that the combat exercises were not designed with China in mind but serve as a deterrence to acts of aggression in the region
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LOUIS (AP) — Victor Scott II robbed Juan Soto of a three-run homer and later hit a tiebreaking double
Louis Cardinals to 5-4 victory over the New York Mets for a doubleheader sweep on Sunday night
The nightcap was tied at 4-all in the fourth inning when Soto drove a fastball to straightaway center
and his glove was over the fence when he snatched the ball
Scott's two-out double off Max Kranick (2-1) scored Yohel Pozo from first base
the NL East-leading Mets have dropped consecutive series for the first time this year
Alec Burleson hit a two-run homer and rookie Michael McGreevy pitched 5 2/3 innings of scoreless relief for the Cardinals
McGreevy (1-0) was recalled Saturday from Triple-A Memphis
He struck out five and gave up one hit and one walk in his first appearance in the majors this season
McGreevy went 3-0 with a 1.96 ERA in four appearances
Mets starter Tylor Megill allowed four runs in five innings
Burleson's first homer this season came with one out in the second
He belted a 0-1 fastball into the right-field bullpen for a 2-0 lead
Starling Marte had two hits and two RBIs for the Mets
The Mets sent nine to the plate in the third against Andre Pallante
McGreevy inherited the bases loaded and retired two batters
Louis tied it in the bottom half on singles by Nolan Arenado and Willson Contreras
Burleson has hit safely in nine of his last 10 starts against the Mets
He is hitting .333 (12 for 36) with three homers and eight RBIs
Mets: Begin a series at Arizona with Griffin Canning (4-1
Cardinals: At Pittsburgh on Monday with Miles Mikolas (1-2
4.66) facing the Pirates' Carmen Mlodzinski (1-3
15 pts.) defeated Carolina Core FC (1-3-4 9 pts.) in a penalty kick shootout 7-6 on Sunday night at MSU Soccer Park
New York opened the scoring in the 20th minute
Defender Matthew Dos Santos whipped in a corner kick onto the six-yard box that was deflected by defender Brooklyn Schwarz and fell to midfielder Rafael Mosquera who volleyed it into the bottom left corner
Late in stoppage time in the first half a red card was issued to Carolina forward David Polanco for a tackle on midfielder Adri Mehmeti
Carolina evened the match in the 51st minute as midfielder Facundo Canete headed a corner kick from defender Paul Leonardi into the back of the net
Red Bulls II earned the lead again in the 75th minute
Mosquera split two defenders with a dribble and crossed the ball onto the six-yard box to midfielder Dennis Nelich who placed a shot into the bottom right corner
Carolina was awarded a penalty kick late in the 90+6th minute
Canete’s initial attempt was saved by goalkeeper Aidan Stokes
but the midfielder converted the rebound to even the match
The match moved to a 10-round penalty kick shootout thriller
Stokes stood out making three saves and converted the shootout winning goal
and Juan Gutierrez also converted on their attempts
Red Bulls II won the shootout 7-6 to earn two points
Nelich made his second appearance with the team and scored his first career MLS NEXT Pro goal
Mosquera scored his second goal of the season and sixth of his career
He also tallied his first assist of the season
Kasule surpassed Andrew Tinari for 10th most minutes played in club history
New York will travel to Belson Stadium on May 9 to face Hudson River Derby rivals NYCFC II
ET with coverage on Apple TV – MLS Season Pass
TORONTO (May 3, 2025) – New England Revolution II (3-1-2, 13 pts.) begin a road-heavy stretch on Sunday afternoon, visiting Toronto FC II (3-2-1, 10 pts.) for its first of five consecutive away matches. Sunday’s match kicks off at 3:00 p.m. ET at York Lions Stadium and is available to watch live on MLSNEXTPro.com
New England enters Sunday’s clash in strong form
claiming points in five of its first six matches to open the 2025 MLS NEXT Pro season
Revolution II is unbeaten over its last two games
following a 2-1 defeat over New York City FC II last Saturday at Gillette Stadium
Last weekend's victory extended the team's unbeaten streak at home to five matches at 3-0-2
Revolution II are tied for third in MLS NEXT Pro for points per game (2.17) and tied for fourth in points (13)
New England ranks sixth in the league in goal differential (+6)
Red-hot forward Liam Butts remains one of the most in-form strikers in MLS NEXT Pro
netting his fourth goal of the season in last weekend's match
has scored in three of the last four games and ranks tied for fourth in tallies in MLS NEXT Pro
Forward Marcos Dias logged the assist on Butts' goal
The Brazilian striker matched his season-high of eight key passes in last Saturday's match
Ugandan midfielder Allan Oyirwoth provided the difference last weekend
netting the game-winning goal for his first tally with Revolution II
The 18-year-old has suited up for five consecutive starts
ranking second on the team in shot attempts (12) this season
Jamaican forward Damorney Hutchinson provided the service on Oyirwoth's goal
18-year-old Academy graduate Eric Klein logged the full 90 minutes
and ranks second on the team in minutes played this season (538)
Revolution II's backline remains one of the strongest in MLS NEXT Pro
New England’s four goals conceded are the second-fewest in the league
while the team has also allowed the fourth-fewest shot attempts (22) leaguewide
Central defenders Victor Souza and Gabe Dahlin
along with full backs Damario McIntosh and Hesron Barry
have all appeared in the last five matches for Revolution II
who owns two shutout performances this season
made three stops last weekend in his third start of the campaign
New England and Toronto will convene for the second of three meetings this season
with the hosts riding a three-game unbeaten streak after a 2-0 defeat of Chicago Fire FC II last Friday
New England holds a 5-3-5 advantage over Toronto in the all-time series
including a 4-0 win in the most recent encounter earlier this season on March 28
highlighted by Butts' two-goal performance
Defending NCAA champion Adelphi and Tampa earned the No
in the NCAA Division II men’s lacrosse tournament
The NCAA announced the full bracket Sunday evening
Most notable among the teams is second-seeded Limestone, which is making its 23rd appearance in the NCAA tournament, second-most all-time in Division II men’s lacrosse. It will also be Limestone’s final appearance after news broke last week that the school will shut down following the end of the academic year
The first round of the tournament is scheduled for Wednesday
A national champion will be crowned at Gillette Stadium in Foxborough
Continue below to see the full 16-team bracket
DENVER, May 1, 2025 /PRNewswire/ -- Lockheed Martin [NYSE: LMT] has completed assembly and testing of NASA's Orion Artemis II spacecraft
transferring possession to NASA's Exploration Ground Systems (EGS) team today
This milestone is a significant step for NASA and the Artemis industry team
as they prepare to launch a crew of four astronauts to further the agency's mission in establishing a human presence on the Moon for exploration and scientific discovery
It will also help build the foundation for the first crewed missions to Mars
Lockheed Martin is the prime contractor to NASA for Orion and built the crew module
crew module adaptor and launch abort system
"This achievement is a testament to our employees and suppliers who have worked tirelessly to get us to this important milestone," said Kirk Shireman
vice president of Human Space Exploration and Orion program manager at Lockheed Martin
"The Orion spacecraft completion for Artemis II is a major step forward in our nation's efforts to develop a long-term lunar presence
humans will see the Earth rise over the lunar horizon from our vehicle
while also traveling farther from Earth than ever before."
Artemis II will put Orion through its final tests in deep space with a crew on board and will include learnings and significant enhancements gleaned from the Artemis I mission
the vehicle is outfitted with a subset of docking sensors and an experimental laser communication system
enabling high data-rate communications and paving the way for future missions
Path to LaunchWith the completion of Orion
the EGS team will perform final preparations on the spacecraft
Orion will soon be moved from the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center to various processing facilities
This is where EGS will load propellants and other consumables
and install the launch abort system and its protective fairings
it will then be transported to the Vehicle Assembly Building
lifted onto the Space Launch System (SLS) rocket and undergo final preparations for launch
Historic Artemis FlightScheduled to launch in early 2026, Artemis II and the Orion spacecraft will host NASA astronauts Reid Wiseman
Christina Koch and Canadian astronaut Jeremy Hansen
Their 10-day journey will include flying 4,600 miles beyond the Moon and back to Earth
the crew will evaluate the spacecraft's performance
test its navigation and communication systems
and conduct a series of scientific experiments
They will perform a rendezvous operation with the SLS upper stage
practicing docking activities needed for future missions including Artemis III – which will mark the first human lunar landing since Apollo 17 in 1972
The Blazing Musket is reader-supported. To receive new posts and support our work, consider becoming a free or paid subscriber.
Richie Williams made four changes from the lineup that secured all three points with a 2-1 win over New York City FC II on April 26th. JD Gunn made a second-consecutive start in goal behind the backline of Hesron Barry, Victor Souza, Gabe Dahlin, and Grant Emerhi. Marcos Dias, Cristiano Oliveira, and Javaun Mussenden formed the midfield trio while Damorney Hutchinson, Liam Butts, and Gevork Diarbian provided the attack.
In addition to the changes, Richie Williams had a thin bench. Max Weinstein, Eli Ackerman, Ivan Villalobos Lopez, Joe Buck, and Judah Siqueira were the only five players on the Revs II bench.
Five minutes into the match, Nathaniel Edwards received the ball on the left flank and slotted it centrally to Jahmarie Nolan who ended up colliding with Barry, which sent both players to the pitch. Despite Barry writhing in pain following the collision, play continued as a series of passes led the ball to land at the feet of Marko Stojadinovic outside the box, who proceeded to rocket a shot that found the back of the net to give Toronto an early 1-0 lead.
After receiving some on-field treatment, Barry’s day ended in the 11th minute as Willams used a concussion substitute to bring on Academy prospect Eli Ackerman to replace Barry.
A great pass from Diarbian into the path of Butts led to success in the 15th minute. Butts got onto the pass and pushed his way into the box before slotting a ball past De Rosario to net his fifth goal of the season and his 10th for the club as Revs II drew the game level.
Butts came close to finding his second goal in the 26th minute when he got under a well-executed cross from Dias and attempted to head the ball home, but De Rosario got his hands to the ball to prevent the go-ahead goal.
Gunn came up big in the 32nd minute after Toronto got rolling off a goal kick, Malik Henry pushed his way into the box and attempted a close-range shot that the goalkeeper made the save on to keep the game tied.
A series of give-and-go passes between Butts and Diarbian led Revs II to take a 2-1 lead in the 39th minute. After getting the ball at midfield, Diarbian advanced before passing back to Butts. After resetting, Butts got the ball up to Diarbian on the left flank and in his usual fashion, the winger flashed his ability to take on defenders as he pushed his way into the box.
Despite having his initial shot deflected, Diarbian stayed with it as he got onto the deflected ball and sent it to the far post. Diarbian’s shot took an awkward deflection off the right goal post but careened into the goal to give Revs II a 2-1 lead.
Things only got better for Revs II in the second half as Diarbian attempted to get onto a loose ball inside the box and was taken down by De Rosario, which led the referee to point to the spot and award New England a penalty kick in the 48th minute.
Dias was the one to step to the spot and De Rosario went the wrong direction as the Brazilian propelled Revolution II to a 3-1 lead.
In the 63rd minute, Malik Henry got an awkward touch on the ball high up the right flank that rolled toward the goal line. Ackerman got onto the ball and attempted to shield it out of play but Henry stuck a foot in at the right time as he dispossessed Ackerman and ran toward goal before slotting a ball centrally to Dékwon Barrow, who smashed it into the goal to shrink Revolution II’s lead.
In the 78th minute, Joshua Nugent darted down the right flank and sent the ball centrally. Dahlin attempted to intercept the pass before it fell to Dékwon Barrow. Unfortunately for Dahlin, the ball deflected off his foot and ricocheted into the net to level the match at three apiece.
Revolution II’s quest for a road win will have to wait a bit longer as things ended in a 3-3 draw following a hectic 90 minutes. Both sides took home a point and headed to a penalty shootout.
Former Vermont Green defender Reid Fisher stepped up to the spot under pressure as he needed to score to keep Toronto in the fourth round of penalties. Fisher stayed cool as he slotted it home to keep Toronto alive.
Following the penalty, it appeared Fisher had some words for JD Gunn that the head referee didn’t appreciate. After racing over, Nivin Raizada brandished Fisher with a red card to end his day early.
Goalkeeper JD Gunn looked to keep Revs II’s hopes alive in the 10th round when he stepped to the spot. Despite the discomfort following a foot save, Gunn came up big as he slotted the ball to the lower-left corner and in to level the shootout.
Captain Victor Souza stepped up to the spot in the 12th round with the opportunity to seal things. After staring down De Rosario, Souza rocketed a shot to the left side of the net. The Toronto goalkeeper dove the right way and got a hand to it, but it wasn’t enough as Souza’s shot crashed into the net to give Revolution II the 9-8 shootout victory after 12 nerve-racking rounds.
After going up 3-1, seeing Revs II only walk away with two points feels a bit disappointing, but you must applaud the group's efforts to stick in despite what transpired.
Revolution II’s winless record on the road will extend a bit further. They’ll look to secure all three points when they face New York Red Bulls II on the road on May 18.
Photo Courtesy of New England RevolutionSunday saw New England Revolution II head north of the border as the club searched for its first road victory since 2023 when they faced Toronto FC II inside York Lion Stadium
consider becoming a free or paid subscriber
Richie Williams made four changes from the lineup that secured all three points with a 2-1 win over New York City FC II on April 26th
JD Gunn made a second-consecutive start in goal behind the backline of Hesron Barry
and Javaun Mussenden formed the midfield trio while Damorney Hutchinson
and Judah Siqueira were the only five players on the Revs II bench
Nathaniel Edwards received the ball on the left flank and slotted it centrally to Jahmarie Nolan who ended up colliding with Barry
Despite Barry writhing in pain following the collision
play continued as a series of passes led the ball to land at the feet of Marko Stojadinovic outside the box
who proceeded to rocket a shot that found the back of the net to give Toronto an early 1-0 lead
Barry\u2019s day ended in the 11th minute as Willams used a concussion substitute to bring on Academy prospect Eli Ackerman to replace Barry
A great pass from Diarbian into the path of Butts led to success in the 15th minute
Butts got onto the pass and pushed his way into the box before slotting a ball past De Rosario to net his fifth goal of the season and his 10th for the club as Revs II drew the game level
Butts came close to finding his second goal in the 26th minute when he got under a well-executed cross from Dias and attempted to head the ball home
but De Rosario got his hands to the ball to prevent the go-ahead goal
Gunn came up big in the 32nd minute after Toronto got rolling off a goal kick
Malik Henry pushed his way into the box and attempted a close-range shot that the goalkeeper made the save on to keep the game tied
A series of give-and-go passes between Butts and Diarbian led Revs II to take a 2-1 lead in the 39th minute
Diarbian advanced before passing back to Butts
Butts got the ball up to Diarbian on the left flank and in his usual fashion
the winger flashed his ability to take on defenders as he pushed his way into the box
Diarbian stayed with it as he got onto the deflected ball and sent it to the far post
Diarbian\u2019s shot took an awkward deflection off the right goal post but careened into the goal to give Revs II a 2-1 lead
Things only got better for Revs II in the second half as Diarbian attempted to get onto a loose ball inside the box and was taken down by De Rosario
which led the referee to point to the spot and award New England a penalty kick in the 48th minute
Dias was the one to step to the spot and De Rosario went the wrong direction as the Brazilian propelled Revolution II to a 3-1 lead
Malik Henry got an awkward touch on the ball high up the right flank that rolled toward the goal line
Ackerman got onto the ball and attempted to shield it out of play but Henry stuck a foot in at the right time as he dispossessed Ackerman and ran toward goal before slotting a ball centrally to D\u00E9kwon Barrow
who smashed it into the goal to shrink Revolution II\u2019s lead
Joshua Nugent darted down the right flank and sent the ball centrally
Dahlin attempted to intercept the pass before it fell to D\u00E9kwon Barrow
the ball deflected off his foot and ricocheted into the net to level the match at three apiece
Revolution II\u2019s quest for a road win will have to wait a bit longer as things ended in a 3-3 draw following a hectic 90 minutes
Both sides took home a point and headed to a penalty shootout
Former Vermont Green defender Reid Fisher stepped up to the spot under pressure as he needed to score to keep Toronto in the fourth round of penalties
Fisher stayed cool as he slotted it home to keep Toronto alive
it appeared Fisher had some words for JD Gunn that the head referee didn\u2019t appreciate
Nivin Raizada brandished Fisher with a red card to end his day early
Goalkeeper JD Gunn looked to keep Revs II\u2019s hopes alive in the 10th round when he stepped to the spot
Despite the discomfort following a foot save
Gunn came up big as he slotted the ball to the lower-left corner and in to level the shootout
Captain Victor Souza stepped up to the spot in the 12th round with the opportunity to seal things
Souza rocketed a shot to the left side of the net
The Toronto goalkeeper dove the right way and got a hand to it
but it wasn\u2019t enough as Souza\u2019s shot crashed into the net to give Revolution II the 9-8 shootout victory after 12 nerve-racking rounds
seeing Revs II only walk away with two points feels a bit disappointing
but you must applaud the group's efforts to stick in despite what transpired
Revolution II\u2019s winless record on the road will extend a bit further
They\u2019ll look to secure all three points when they face New York Red Bulls II on the road on May 18
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● JETAV Flight Academy acquires an A320 FNPT II MCC simulator from Entrol
strengthening its fixed-wing pilot training capabilities
● The simulator is equipped with a 200ºx40º cylindrical visual system
offering an immersive and high-quality training experience
JETAV enhances its training capabilities for students ranging from PPL to ATPL
with a focus on preparing pilots for airline careers
Madrid, May 6th, 2025 - Entrol
the manufacturer of EASA and FAA certified FNPT
has announced the sale of an A320 FNPT II MCC simulator to JETAV
a renowned aviation school and aircraft operator in Romania
now installed and fully operational at JETAV’s facilities
will be used for initial fixed-wing pilot training and for preparing future airline pilots
A Complete Solution for Airline Pilot Training
The A320 FNPT II MCC simulator replicates the cockpit of the Airbus A320
providing a realistic flight experience for training pilots
Equipped with a 200ºx40º cylindrical visual system
pilots will benefit from immersive visualization during training
The simulator includes a basic database covering key airports in Europe and the Middle East
including Romanian airports and international destinations like EDDF (Frankfurt)
Advanced Capabilities for a Complete Training Experience
allows remote management of the simulator's IOS
integrated with ForeFlight and GarminPilot to facilitate flight planning and monitoring
This technology ensures that instructors and trainers can interact seamlessly with the simulator
maximizing training efficiency and effectiveness
A Reference in Training Future Airline Pilots
With the addition of this A32 FNPT II MCC simulator
JETAV strengthens its capacity to offer quality training
enhancing the learning process and ensuring students are well-prepared for the challenges of the aviation industry
commented: "This simulator represents an important step for JETAV in its commitment to pilot training
We are proud to continue offering our clients high-quality simulators that meet the most demanding industry standards
JETAV will be able to offer more comprehensive and realistic training
bringing their cadets closer to real-world flying experiences."
About EntrolEntrol is one of the world’s leading manufacturers of certified flight simulators
we have been driven by passion and innovation to deliver our customers a complete solution
from initial certification to lifetime simulator maintenance
With flight simulators certified in more than 35 countries worldwide
our mission is to develop high-quality EASA and FAA training devices to help flight schools and operators provide the best training to their pilots
About JETAVJETAV is a leading flight school in Romania
With a fleet of modern flight simulators and aircraft
JETAV offers comprehensive programs for obtaining Private Pilot Licenses (PPL)
and specialized training for the aviation industry
The school is committed to providing the best possible training
equipping students with the experience and knowledge needed for success in the aviation sector
For more information, visit www.entrol.net
California firefighters witnessed water drops from an autonomous Black Hawk® helicopter guided by Rain wildfire mission autonomy technology
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New System Replaces Legacy Tools with Streamlined Data Capture
28 April 2025: A growing shortage of qualified engineers in the aviation sector has seen Australia’s largest heli-aviation operator,..
7 points) closes out the week with MLS NEXT Pro regular season action at home
with the team hosting New York City FC II (2W-4L-2D
Kick off at Chase Stadium is slated for 7 p.m
This match will be available for fans to stream at MLSNEXTPro.com or by clicking HERE
Inter Miami II and NYCFC II have faced off seven times
with NYCFC II holding the upper hand in the series
The Herons have claimed just one victory—a thrilling 3-2 triumph in the 2024 season opener
highlighted by a standout performance from current First Team forward Leo Afonso
Currently eighth in the Eastern Conference
NYCFC II enters this match winless in their last five games
The visitors will be led by USMYNT midfielder Máximo Carrizo
who tops their goal contributions chart with one goal and three assists and remains a key threat in the final third
This timing could be ideal for Mother's Day gifts
Amazon estimates both could arrive by May 6
potentially landing five days before the holiday (May 11)
Just be sure to double-check the estimated delivery date for your location at checkout
The Major V headphones feature Marshall’s signature sound (heavy bass and crisp highs)
and a customizable M-Button to get quick access to Spotify
The Motif II earbuds offer up to 30 hours of playtime with the charging case and up to six hours of wireless playtime with ANC
The Marshall app makes it easy to adjust EQ settings and noise cancellation levels
and transparency mode lets you hear what’s happening around you
She has a Master's degree in Creative Publishing and Critical Journalism from The New School of Social Research and is a grad of Sextech School
You can find more of her work in various online pubs
Dutch police arrested five pro-Palestinian protesters on Monday during a World War II anniversary event in Wageningen
Security personnel detain a Pro-Palestinian protester
where they commemorate the victims of war and celebrate freedom
A police spokesperson said the arrests were for disturbing public order
As the city marked the 80th anniversary of Dutch liberation at the end of World War II in Europe
gathered to voice opposition to the Israel-Gaza war and demand the Dutch government speak out against it
never again” and “Don’t give hate power,” a Reuters witness saw
They also held an 80-meter (262 ft) long red banner
with an accompanying text that described it as a symbol of “the red line the government refuses to draw,” referring to the Dutch government
During a speech by Dutch Prime Minister Dick Schoof
Dutch media reported a protester threw a smoke bomb onto the stage
where visiting Polish Prime Minister Donald Tusk was also present
The police spokesperson was unable to clarify whether the protester was among those arrested
saying that Europe’s era of comfort and freedom was over
and that the lesson of 80 years ago was that nations had to be united to overcome the challenges they face
Several World War II veterans also attended the event
who lit the National Liberation Fire just after midnight on Monday
The public greeted them with a loud cry of “thank you.”
8 pts) at MSU Soccer Park on May 4 at 5:00 p.m
New York is finding a good run of form as they have won three of their last four matches
They've scored a total of 11 goals in this span
In each win they've scored three or more goals
The team is also yet to be held scoreless through the season
joining Carolina Core FC and Huntsville FC as only clubs in the Eastern Conference to score in each game played in 2025
Midfielder Ibrahim Kasule is off to a strong start to the season
Uganda native has two goals and three assists for a total of five goal contributions
Kasule most notably had a one goal two assist performance in Red Bulls II's previous match against Orlando City B
New York are undefeated at home this season
They earned 3-2 victories over NYCFC II and Chicago Fire FC II on March 30 and April 6
ET with coverage available on Apple TV – MLS Season Pass
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Robert Leslie Kennedy II passed away peacefully on May 3
service and deep devotion to those he held dear
He proudly served in the United States Navy from 1947-1952 aboard the aircraft carrier USS Mindoro
affectionately known as the "The Mighty Minnie."
Robert earned a degree in mechanical drafting from Ferris State University
where his skills and work ethic were highly respected
Their 69 years of marriage were filled with unwavering love
and a growing family that brought them both endless joy
they raised seven children: Robert and Vickie Kennedy
Robert was a devoted grandfather to 17 grandchildren and a proud great-grandfather to 25 great-grandchildren
we celebrate a life well lived and find comfort in the promise of reunion
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Photo courtesy Philadelphia Union II Communications
After slightly more than a one hour rain and lightning delay in Chattanooga
Philadelphia Union II drew to hosts Chattanooga FC in regulation 0-0 and won a twelve round penalty kick shootout 9-8
The shootout victory secures two points against the conference leaders as Union II remain undefeated with two wins and four draws in six games
and end up in fifth place in the east with two games in hand
Andrew Rick had five saves in regulation including one against a breakaway
and four in the shootout – adding a spot kick goal of his own in the shootout
Nick Pariano once again was masterful at defensive midfielder
From PSP’s perspective they are both the Men of the Match
For the first time this season the Philadelphia Union and Philadelphia Union II played simultaneously and away
forcing the technical staff to allocate its deep reserves to only one or the other
Aside from the on-going surgical recovery of Ian Glavinovich
but Bradley Carnell said something last Thursday about a stomach bug making the rounds
the first team was beginning its 29-day stretch of eight games that could become nine if they advance in the Open Cup past USL Championship’s Indy Eleven next Wednesday
that would require playing on the third day after the previous match for four consecutive weeks
Attacking mid Cavan Sullivan was not available to Union II
Center back Neil Pierre and versatile mid David Vazquez were
Strikers Sal Olivas and Eddy Davis played for the second team as they usually do
Striker Markus Anderson was unaccounted for
eastern conference first place holder Chattanooga was at full strength
And as the hunting cliché goes they were loaded for bear because they were coming off their first loss (to Columbus Crew 2
Missing both Stas Korzeniowski and Markus Anderson from the forward line
Philadelphia lacked its usual degree of holdup play from its forwards
While Kellen LeBlanc showed improved athleticism and defensive ground coverage for the first 20 minutes in his first start of the season
the other fifty-five minutes of his shift had less effect on play
Last summer’s gawky young colt who could barely control his brand new longer legs now consistently covers ground with pace when he’s fresh
The first fifteen minutes saw Chattanooga on the front foot
Then Union II began to have longer spells of possession and offensive pressure until the half’s last fifteen minutes when the pace slowed as fatigue set in
Cavan Sullivan’s offensive contributions and constant defensive pressure were missed as he traveled with the first team
Missed even more was a smoothly coordinated midfield foursome that plays well together
Head coach Ryan Richter needs time to have all of the possible combinations of offensive parts to practice working together
MinJae Kwak replaced Markus Nagelstad in the offense
replacing CJ Olney in the midfield swapping spots with David Vazquez who moved forward into an attacking midfield role while while he Bernstein joined Pariano as a double six
The balance of the match changed in the second half
the Union II held a possession advantage and made more passes than their hosts
but Chattanooga’s defense remained stout
For the last six minutes of regulation the visitors were without center back Neil Pierre due to injury
Richter deserves full credit for his adjustments
and placed Oscar Benitez at defensive mid next to the debutante Bernstein
a credit to the players for their poise and to their coaches for practice preparing them to adjust
May 11th hosting Columbus Crew 2 at 3:00 PM
1 Olney’s departure at halftime may have been stomach flu
but otherwise might indicate he has a role to play in this coming Wednesday’s U
2 Isaiah LeFlore not only had a crucial goalie clearance in the 48th minute to preserve the clean sheet
but also played his best defensive game of his Union II career
3 Rafael Uzcategui continues to impress at center back
Gavin Wetzel; David Vazquez (Gio Sequera 85′)
Nick Pariano; CJ Olney (Henry Bernstein HT)
Kellan LeBlanc (Leo Soria 76′); Sal Olivas (StasKorzeniowski 68′)
Unused Substitutes: Mike Sheridan; Ramzi Qawasmy
Starters: Eldin Jakupovic; Ethan Dudley (Logan Brown 83′)
66th minute Tate Robertson (foul)
American equipment provider GE Aerospace has secured a contract to supply eight additional LM500 marine gas turbine engines for the Republic of Korea Navy’s (ROKN) PKX-B Batch-II patrol boat program
this order follows the March 2023 selection for vessels one through four and the vessels five through eight in March 2024
The new contract covers the equipment for ships nine through twelve
The LM500 gas turbine hardware will be manufactured in Lynn
which will assemble and test the engines before delivering them for installation
Hanwha also co-manufactures engine components for the ROKN and provides spares and services support for the life of the ship
The PKX-B Batch-II patrol boats are expected to enhance the ROKN’s littoral defense with rapid response and firepower in coastal and near-shore operations
According to GE Aerospace
and fuel efficiency serve as the boost engine in a combined diesel and gas turbine (CODAG) configuration
This configuration allows the PKX-B Batch-II vessels to achieve high speeds for rapid response missions while maintaining fuel economy during cruising operations
“This contract award reinforces GE Aerospace’s position as a trusted provider of marine propulsion systems for navies that demand the best,” said Mark Musheno
GE Aerospace Marine Engines & Systems business
“We are pleased to extend our long-standing relationship with the Republic of Korea Navy
soon to be powering 77 ships with 156 marine gas turbines.”
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‘Clock Tower’-Inspired Survival Horror Title ‘Midnight Special’ Launches May 8 on Steam [Trailer]
Body Horror Sim ‘Zoochosis’ Announced for PlayStation Consoles [Trailer]
Warning: This article contains spoilers for this week’s episode of “The Last of Us,” which is available now to stream on Max
The previous episode of HBO’s “The Last of Us“ ended with Ellie (Bella Ramsey) and Dina’s (Isabela Merced) arrival in Seattle in pursuit of Abby (Kaitlyn Dever)
unaware that they’ve stumbled into an ongoing war between militia group Washington Liberation Front (WLF) and the cult group Seraphites
“Day One,“ gives a closer look at the cruelty this intense battle inspires from both sides
“What the f*ck is wrong with Seattle?”
That question is directly inspired by the aftermath of a grisly scene in which the Seraphites
a primitivist cult known for their facial scars and eerie whistles
had strung up and disemboweled a group of WLF soldiers with a message referring to their Prophet written in blood
It’s a far cry from their introduction last episode
which presented a more peaceful faction of their group fleeing the fight for greener pastures only to be ruthlessly culled down by “wolves,“ or the WLF
It’s a scene that provides the first indication that the Seraphites are capable of fighting back and just as vicious as their enemy
arriving after a key scene that brings one of The Last of Us Part II video game’s characters into the fold in a prominent way
In the season two premiere of “The Last of Us,“ as Abby’s group debates where to go now that the Fireflies are gone
“Ed has a brother who runs an outfit in Seattle
A guy named Isaac.” It’s a casual line
one that “Day One“ puts into new focus as it gives a much more thorough introduction to Isaac Dixon
a secondary antagonist in the game voiced and motion captured by actor Jeffrey Wright
“Day One“ establishes Isaac’s smarts and cunning with a shocking scene of his departure from FEDRA (Federal Disaster Response Agency) as a sergeant in Seattle’s Quarantine Zone by blowing up his armed truck full of soldiers to join the ranks of WLF
Isaac hasn’t lost his icy edge at all as he interrogates a chained and abused Seraphite with violence
using a scalding pan to coax out answers through blistering pain
When that fails to yield answers on the Seraphite’s next plan of attack
The series stops there from divulging any more information about Isaac or his motivation
but it’s enough to paint a clear picture that Ellie and Dina’s path to revenge will be hampered at every step by a wartorn Seattle
That’s evident by the episode’s end
where the pair look on in horror as a battle wages on miles away
It also establishes to viewers that Isaac’s still-to-be-revealed connections to Abby will create another lethal obstacle for Ellie
The silver lining of the episode comes in the aftermath of an intense escape from a Clicker infested tunnel resulting in Ellie getting bitten
As Dina tearfully prepares to pull the trigger
Ellie is forced to reveal her most closely guarded secret: her immunity
Once Dina is satisfied that Ellie is telling the truth
she pulls out a confession of her own: her pregnancy
“Day One“ lays expansive groundwork for the rocky road ahead
with a complex war raging in Seattle and an unlikely duo with all of the odds stacked against them at the center of it
Grief Gives Way to Vengeance in ‘The Last of Us’ Season 2
‘The Last of Us’ Just Delivered the Show’s Most Devastating Moment [Spoilers]
The 5 Biggest Takeaways from “The Last of Us” Season 2 Premiere [Spoilers]
It’s a fairy tale with a gruesome body horror twist
This week’s streaming picks highlight other fairy tale-inspired horror movies
whether they’re direct adaptations or loosely based on them
All blend horror and fantasy to deliver cautionary bedtime tales of the bloody variety
Here’s where you can stream these fairy tale inspired horror movies this week
For more Stay Home, Watch Horror picks, click here.
writer/director Mike Flanagan drew inspiration from a few urban myths about tunnels and trolls
and that also includes the Norwegian fairy tale Three Billy Goats Gruff
So much that it directly factors into the plot
Flanagan mainstay Katie Parker stars as Callie
a recovering addict who comes to stay with her pregnant sister
Tricia’s finally ready to accept that her missing husband is dead
but then Callie encounters a strange man in an empty tunnel
It’s the beginning of a series of strange events stemming from the tunnel
including a supernatural bargain Callie unwittingly strikes
Leave it to Flanagan to use urban legends and fairy tales as a haunting and unsettling exploration of grief
Before Jaume Balagueró teamed up with Paco Plaza to unleash one of the most terrifying movies of the decade
he proved an aptitude for delivering chills with this underseen haunted hospital fairy tale
a nurse brought on to the night shift in the children’s ward at an old hospital in the process of closing
but her new gig comes with a malevolent ghost
Fragile is creepy and atmospheric with effective scares
but even better is that Balagueró gives this ghost story an emotional center loosely inspired by Sleeping Beauty
filmmaker Oz Perkins reconfigured the classic Grimm fairy tale for a moodier horror story that favors style over a more conventional
Think unparalleled production design with impressive sound design and score to match
but with its story told in an unconventional and sometimes muddied way
the elder sister tasked with protecting her brother from Alice Krige‘s mesmerizing Witch
It’s a coming-of-rage sort of fairy tale
that sets this adaptation of a classic fairy tale apart
It’s also in the stunning stop-motion animation
Director Jiří Barta’s 1986 Czech adaptation of Pied Piper of Hamelin introduces a corrupt village consumed by greed and pettiness
they turn to a mysterious stranger who offers to lead the rats out of the town for a price
Barta’s hand-crafted feature draws from German expressionism
gloomy style that suits the horror of this fairy tale well
Based on a collection of stories by Italian poet Giambattista Basile
this dark horror fantasy film is an anthology that delves into the earliest versions of well-known fairytales; but not always the most obvious ones
this fairytale isn’t afraid of gruesome bloodshed
and a vain king who prefers to flay the skin of his victims
It also boasts a large ensemble cast of recognizable talents like Salma Hayek
The week of May 5-9 is shaping up to be a good one if you're an Xbox gamer
with a ton of great titles headed to Xbox Series X|S
Age of Empires II: DE – The Three Kingdoms (Xbox Game Studios) comes to PC, Xbox One and Xbox Series X|S on Tuesday on sale for $16.99. You can preorder it right now and "Dive into the epic Romance of the Three Kingdoms with the latest expansion for Age of Empires II: Definitive Edition
where history and legend collide in a battle for supremacy
Battle your way across China with three new campaigns
Only for Xbox Series X|S, King Arthur: Legion IX is a "turn-based, character-centric tactical RPG in the King Arthur: Knight's Tale universe - a dark fantasy version of the Arthurian myth. This DLC is available to players of the original game on console on May 6
Also available on Tuesday, Metal Eden from Deep Silver comes to the Xbox Series X|S
promising an "adrenaline-rush sci-fi FPS" set in a massive futuristic city
You'll get to "Blast your way through the Internal Defence Corps in cybernetic warfare
confront the Engineers and uncover the mysteries of the project Eden."
Wednesday May 7 will see the release of the roguelite action game Submarine Survivor from Eastasiasoft Limited and sci-fi RPG Empyreal from Secret Mode
Finally, Friday's releases will be puzzler Amaze and Eyes: The Horror Game
both in the $4-$5 range and available on Xbox One
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who currently occupies centerfield for the St
Scott not only prevented the Cardinals from falling behind a few runs earlier in the game
but he also came up with the biggest hit of the night to send the Cards home happy
New York Mets slugger Juan Soto sent a rocket to straightaway centerfield where Scott leaped up against the wall and pulled back the ball for the out
VICTOR SCOTT II!!!He shows off the hops to rob Juan Soto of a homer! pic.twitter.com/BDHiUPu6Am
Scott came through in the clutch with an RBI double to right centerfield off of Max Kranick
which ended up being the eventual game-winning run
Scott struggled at the plate as a rookie with a measly .179 batting average
Through the first 31 games of the 2025 season
Scott is slashing .286/.356/.419 with two homers and 15 RBI
while going a perfect 11 for 11 on stolen base attempts
Jayden Stone Transfers Out of WVU, Lands with SEC Program
MAILBAG: Braydon Hawthorne Update, Alabama Series, Press Box, D-II/JUCO + More
West Florida Defensive Back Tyrence Crutcher Commits to WVU
West Virginia Lands Another SEC Transfer Offensive Lineman
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where she had formally appointed more than a dozen prime ministers
aside from the traditional and ceremonial duties
she became a keen horsewoman; she kept racehorses
and periodically visited the Kentucky stud farms in the United States
Her financial and property holdings made her one of the world’s richest women
DENVER - Lockheed Martin has completed assembly and testing of NASA’s Orion spacecraft for the Artemis II mission and officially transferred it to NASA’s Exploration Ground Systems team on May 1 for final launch preparations
"This achievement is a testament to our employees and suppliers who have worked tirelessly to get us to this important milestone," said Kirk Shireman
humans will see the Earth rise over the lunar horizon from our vehicle."
The Artemis II Orion spacecraft includes major upgrades from earlier test flights, with new systems to support crew health and safety, such as life support, thermal control, waste management, audio communications, and an exercise machine. It also features a functional launch abort system, partial docking sensors, and an experimental laser communications system for high-data-rate transmissions
NASA provides update on Artemis missions, heat shield investigation findings
NASA’s team at Kennedy Space Center will complete spacecraft processing
and stacking the vehicle atop the Space Launch System rocket inside the Vehicle Assembly Building
Lockheed Martin continues to build Orion spacecraft for future Artemis missions
with vehicles for Artemis III and IV already under assembly
The company holds a contract with NASA through Artemis VIII and reports cost reductions with each successive spacecraft
Jamie Whitney joined the staff of Military & Aerospace Electronics and Intelligent Aerospace
He brings seven years of print newspaper experience to the aerospace and defense electronics industry
Whitney oversees editorial content for the Intelligent Aerospace Website
as well as produce news and features for Military & Aerospace Electronics
oversee print production of Military & Aerospace Electronics
and expand the Intelligent Aerospace and Military & Aerospace Electronics franchises with new and innovative content
Q: Is there any update on Braydon Hawthorne
Is there still a chance we get the number 1 player in WV
A: Things have been kept close to the vest with this one
I get the sense that Hawthorne is headed elsewhere
but I wouldn't completely rule out West Virginia
The Hokies wouldn't have any chance in this battle if it weren't for Chester Frazier
I do know he has a strong relationship with him
and they're doing everything they can to land him
The fact that he's been in contact with Ross Hodge and the new staff is a positive sign
Q: How many more guys do you see Rich Rod adding to the football team
It seems like we keep contacting guys just to have to cut some more lol
Limiting the roster to 105 is not an official ruling just yet
didn't seem too gung-ho about a big one-time cut down to 105
It feels like she wants it to be a multi-year process to reduce the number of cuts
Rich Rod is going to have to send more kids packing
but you'd rather have too many players and be forced to cut than not have enough quality players and get stuck
Q: How is the bball team doing...and how is the progress coming towards high school recruits - tons of ground to make up
I would expect much of the roster to be in place within the next two and a half weeks
I assume that Ross Hodge would like to get his top targets on campus before that period begins
Q: What do you need to see this year to have faith we’ll win against Bama next year
A: My mind has not even thought about Alabama once
it's difficult to know what the makeup of the roster will look like from year to year
Maybe WVU gets a stacked roster and competes nationally in 2026
Or perhaps they get gutted and have to retool
I can't answer this with conviction until this time next year
seeing this team take on the identity of its head coach and playing the style of ball that he preaches daily is what I'm looking for
Q: Any update on ever updating our press box
It’s so outdated and undersized compared to almost every other Power Five stadium in the country
It’s a concrete box eyesore and needs a facelift or to be torn down and replaced
A: The exterior certainly isn't a thing of beauty
There's plenty of space and nothing is falling apart
Comparing it to some of the others I've been in
it's the last thing that needs to be touched
I do agree that a brand new one would be better on the eyes
but the money needs to go more into facilities and to the roster more than ever
I highly doubt they're going to completely redo our view in the sky
similar to what they did with the player posters on the columns of the stadium in the concourse
I know Wren Baker would like to find a way to work it out and patch the gap that exists with the Backyard Brawl
If the SEC goes to nine games in league play
Do they really want to play nine SEC games plus West Virginia
then WVU can attempt to play the game then and move UT Martin to Sept
A lot of moving pieces and not a whole lot of time left to get things shifted around
Q: I mean zero disrespect to Coach(s) or players
We are acquiring a lot of recruits from JUCO/ DII levels etc..
From my "understanding," these leagues are much grittier
*Do you think that Coach(s) are delving into these divisions for not only NIL savings
may have played a few years at a college level
and can potentially gain those years of eligibility back for playing at this level
for the next few years (gaining players that have played at the collegiate level
do you think this influx of new players has the potential to be B12 contenders by 2026
I do think it's certainly a part of the evaluation piece
When you don't have the same financial resources that the big dogs have
you have to find creative ways to land the best talent
Sometimes that's searching for overlooked players or just looking in places those guys aren't looking
Those kids from the lower levels are certainly hungrier because they haven't been given anything
They didn't have the luxury of being able to fly to games
Doing so in year one is a major ask and unfair expectation for the coaching staff
To participate in next week's mailbag, send me a DM on X (@Callihan_) reply to my tweet asking for submissions on Saturday, or place your question in the comments section under my post on Facebook
JUCO Defensive Lineman Elijah Simmons Commits to West Virginia
No. 16 West Virginia Shuts Out Texas Tech, Takes Series
The Chicago Cubs and St. Louis Cardinals boast one of the most time-honored rivalries in Major League Baseball
While the two teams are presently trending in opposite directions – the Cubs have been one of the game's best teams thus far in 2025
while the Cardinals are presently below .500 – there's a compelling rivalry "writ small" in center field
There's another layer to things when two natural rivals have promising young players manning the same position and, in this instance, enjoying breakout campaigns at the same time. We speak of the emerging Interstate-55 rivalry in center field between Pete Crow-Armstrong of the Cubs and Victor Scott II of the Cardinals
This seems a timely matter because Crow-Armstrong right now ranks third in the National League in WAR with a mark of 2.0, meaning he's been one of the best overall players in baseball thus far. Scott, meantime, is 10th on that same list with a WAR of 1.4, and during Sunday's doubleheader sweep of the New York Mets
he went a combined 3 for 6 with a pair of walks and this miracle robbery that wound up mattering quite a bit insofar as the final score is concerned:
VICTOR SCOTT II WITH ONE OF THE BEST CATCHES EVER! pic.twitter.com/jgX1R96qgy
Crow-Armstrong profiles as the superior player right now and thus moving forward
was consistently a higher-ranked prospect in the minors
and is more than a year younger than Scott
those substantial advantages don't mean all is decided
It's fully within the range of possibilities that Scott closes the gap between them or even surpasses Crow-Armstrong at some point
his multi-faceted strides in 2025 come after a deeply disappointing 2024
he was pressed into regular duty by injuries
in part because he'd been skipped past Triple-A entirely
Louis and didn't fare much better after being demoted to Memphis
Scott relocated to the Cardinals' training complex in Jupiter
and devoted himself to improving in the field and at the plate
He now gets better reads in center and trusts his first step
incorporating a stride has made him far more athletic
and he's realized impressive strides at pitch recognition
and – critically for someone with his speed – he has an OBP of .356
drawing walks in 10.1% of his plate appearances
Scott leads the majors in bunt singles with five
he's stolen 12 bases in as many attempts this season
and through the first 84 games of his big-league career he's yet to hit into a double play
As for PCA, our own Matt Snyder recently explored his ongoing breakout and noted that Crow-Armstrong's value in the field and on the bases has never been in doubt
and 2025 to date has yielded very encouraging returns on that front
PCA has 20 extra-base hits in 35 games and a 140 OPS+
He's backed up the thump with a high quality of batted balls
especially when it comes to his knack for finding the barrel (he's in the 78th percentile among big-league hitters in terms of registering the ideal combination of exit velocity and launch angle off the bat)
There are concerns about PCA's extreme tendency to chase pitches outside the strike zone and his low walk rate
but his capacity to punish the ball is legitimate
and he's hit into zero double plays this season
The good news for PCA and Scott is that even when their bats aren't at peak
their elite defense and base-running provide an all-but-unshakeable foundation of value that make them "high floor" players
Statcast puts Crow-Armstrong in the 99th and 100th percentile of base-running and fielding value
Scott is in the 99th and 95th percentile in those measures
Scott is in the 100th percentile in sprint speed
then they're All-Star-caliber in Scott's case and MVP-caliber in PCA's case
let's pair Scott's defensive highlight above with one from PCA
This is something the writer likes to call "The Andruw Jones Experience." It's a catch the difficulty of which is submerged within the mellow smoothness with which the fielder made it
Not only did PCA make a catch that another big-league center fielder failed to make on an effectively identical batted ball
but PCA also did it without lunging or laying out for it
He made it look more routine than highlight-worthy
the miracle of technicolor television sometimes punishes PCA (and Scott
A fly-catcher with lesser range – and almost all fly-catchers have lesser range than Crow-Armstrong does – makes the tape because he requires a crowd-rousing dive to reach that ball
but it says here that slick-fielding speedsters who man center and employ some daring on the bases are perhaps the most aesthetically pleasing sub-genre of ballplayers
On top of providing quality baseball entertainment
Consider it a tidy bonus that they play for time-honored arch rivals who share a division and swaths of the same territory
but this debate figures to be a years-long one and perhaps an ever-changing one
has signed a letter of intent to join the St
who'll have two years of eligibility with the Bonnies
efficient and ever-improving player in his two seasons at Gardner-Webb
He was voted second-team All-Big South in the 2024-2025 season
Simmons averaged 17.4 points on 39 percent three-point shooting – including 22 points against Pittsburgh of the Atlantic Coast Conference and a school-record 40 points against Winthrop on 8-for-12 three-point shooting
Simmons had 10 games of 20-plus points for Gardner Webb to go along with 3.2 rebounds and 1.9 assists a game
Simmons' scoring average increased over 15 points per game from the 2023-24 season – with his minutes moving from 9.4 a game to 33.4
Prior to Gardner-Webb, Simmons II was a standout player for Putnam Science (Conn.) Academy that posted a combined record of 77-3 during his time with the team, winning a pair of national championships. He played for current Bonnies assistant Dana Valentine
who was an assistant under legendary Putnam coach Tom Espinosa and assistant Josh Scraba
Simmons joins a distinguished Putnam Science alumnus history at St. Bonaventure that includes Kyle Lofton, Osun Osunniyi and Charles Pride
Simmons II led Putnam to a 39-3 season and a national prep title
five assists and two steals – including shooting 94.4 percent from the free throw line
Simmons II led Putnam to a 38-0 national championship season
Simmons II finished his career at Putnam Science Academy as the program's all-time leader with 147 made three-pointers
His 94 games played are second in program history while also ranking third in steals (137)
fourth in assists (336) and seventh in points scored (914)
What they're saying about Darryl "Buddy" Simmons II
Mark Schmidt
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Metrics details
In this phase I/II trial at Kyoto University Hospital
seven patients (ages 50–69) received bilateral transplantation of dopaminergic progenitors derived from induced PS (iPS) cells
Primary outcomes focused on safety and adverse events
while secondary outcomes assessed motor symptom changes and dopamine production for 24 months
Patients’ anti-parkinsonian medication doses were maintained unless therapeutic adjustments were required
Magnetic resonance imaging showed no graft overgrowth
Among six patients subjected to efficacy evaluation
four showed improvements in the Movement Disorder Society Unified Parkinson’s Disease Rating Scale part III OFF score
and five showed improvements in the ON scores
The average changes of all six patients were 9.5 (20.4%) and 4.3 points (35.7%) for the OFF and ON scores
Hoehn–Yahr stages improved in four patients
Fluorine-18-l-dihydroxyphenylalanine (18F-DOPA) influx rate constant (Ki) values in the putamen increased by 44.7%
with higher increases in the high-dose group
This trial (jRCT2090220384) demonstrated that allogeneic iPS-cell-derived dopaminergic progenitors survived
produced dopamine and did not form tumours
therefore suggesting safety and potential clinical benefits for Parkinson’s disease
Parkinson’s disease (PD) is characterized by the loss of dopamine (DA) neurons in the substantia nigra
leading to a motor syndrome characterized by bradykinesia
Medical treatment effectively alleviates PD symptoms in the early stages
but chronic use results in complications such as motor fluctuations and drug-induced dyskinesias
cell therapies to replace lost DA neurons have been investigated as an alternative treatment
we received approval from the Japanese government and the institutional review board of Kyoto University
Here we report the results of our clinical trial launched in 2018
Patients were recruited and evaluated at Kyoto University Hospital between August 2018 and January 2019
The first three patients were categorized into the low-dose subgroup
while the remaining four were classified into the high-dose subgroup
One registered patient was excluded before surgery owing to a COVID-19 infection
The first patient received unilateral surgeries with an eight-month interval between procedures and was included only in the safety assessment
Efficacy analysis was conducted on the remaining six patients
the patients were enrolled in this clinical trial and underwent neurological evaluation for more than 6 months
If no notable symptomatic changes were observed during this period
patients were re-enrolled for surgery and underwent further neurological evaluation (including MDS-UPDRS) and an 18F-DOPA PET study
brain imaging (MRI and PET) and neurological assessments (including MDS-UPDRS) were performed at 3
PET studies included 18F-DOPA (to assess DA synthesis)
18F-GE180 (to detect inflammation) and 18F-FLT (to assess cell proliferation)
tacrolimus (0.06 mg per kg twice daily) was administered
with the dosage adjusted to maintain target trough levels of 5–10 ng ml−1
The dose was reduced by half at 12 months and discontinued at 15 months
Tacrolimus (0.06 mg per kg twice daily) was administered and adjusted to target trough levels (5–10 ng ml−1)
with the dosage reduced by half at 12 months and discontinued at 15 months
differentiated into tyrosine hydroxylase-positive (TH+) DA neurons
improving the rotational behaviour of PD model rats
and Ki-67+ (a maker for proliferating cells) cells were less than 1.0% and sparsely distributed in the grafts
no 5-hydroxytryptamine (5-HT)-positive cells (a marker for serotonergic neurons) were detected
No serious adverse events necessitating hospitalization or resulting in death were reported. All 7 patients (100%) experienced a total of 73 adverse events, comprising 72 mild events and one moderate case of dyskinesia (Supplementary Table 2)
The most frequent adverse event was application site pruritus
There were no apparent differences in the spectrum
frequency and severity of treatment-related adverse events between the low-dose and high-dose groups
and most were unlikely related to either cell transplantation or tacrolimus
The single adverse event possibly related to cell transplantation was neck stiffness and painful dystonia in the right upper limb during the drug-on state
Tacrolimus administration was well tolerated but potentially associated with adverse events in three patients (42.9%)
increased gamma-glutamyltransferase levels (n = 1)
nail dermatophytosis (n = 1) and renal impairment (n = 2)
indicative of apparent inflammation in the putamen and surrounding areas
Chronological changes in the UDysRS scores for each patient from registration (0 months) to the end of the observation period (24 months) for safety assessment
with the mean represented by the black line
Absolute and relative (percentage) changes at 24 months are shown on the right
Chronological changes in MDS-UPDRS part III scores during the medication-off (c,d) and medication-on (e,f) periods for each patient from registration (0 months) to the end of observation (24 months) for efficacy assessment
The absolute and relative (percentage) changes at 24 months are shown on the right
Source data
Chronological changes in 18F-DOPA Ki values (average of both sides) in the putamen for each patient from registration (0 months) to the end of the observation period (24 months)
The Ki value changes from the baseline; the mean is represented by the black line
The 18F-DOPA Ki value (average of both sides) changes from the baseline in the caudate nucleus for each patient
indicating pathological deterioration in PD
The ratio of Ki values between the putamen and the caudate nucleus
highlighting the impact of cell transplantation on pathological deterioration
The percentage changes at 24 months are shown on the right
Semiquantitative 18F-DOPA images generated at 80–90 min after injection by subtracting the occipital background signal and normalizing the result to the occipital activity in patient PD08
The colour change from dark green to red in the bilateral putamen indicates increased 18F-DOPA uptake
Source data
Although PS cells are expected to be an alternative donor cell source to hfVM
the safety and efficacy of iPS-cell-derived DA progenitors remains unclear
This first clinical trial using iPS cells confirmed that iPS-cell-derived DA progenitors can survive without forming tumours and produce DA in the putamen of patients with PD
there were no serious adverse events or GIDs
Four out of six patients showed improvement in MDS-UPDRS part III OFF at 24 months after transplantation
suggesting that grafted cells functioned as DA neurons
While such effects may also apply to our trial
further confirmation through long-term follow-up and post-mortem histological examinations is necessary
The spectrum of adverse events was similar to those encountered with chronic DA replacement medication
tacrolimus administration and brain surgery
Neck stiffness and painful dystonia in the right upper limb were noted in PD01 during the drug-on state
a phenomenon possibly related to the grafts
Tacrolimus- and surgery-related adverse events were manageable and reversible
we purified CORIN+ medial plate cells and eliminated lateral plate cells
we detected no 5-HT+ cells in donor-cell-derived grafts in rat PD models
This purification process may have contributed to the absence of GIDs in our trial
our positron-emission tomography (PET) study at 3
6 and 12 months showed no 18F-GE180 uptake
suggesting the absence of severe inflammation
we discontinued tacrolimus treatment at 15 months
no inflammation due to immune response was observed in the putamen and surrounding areas
as evident by the absence of hyperintensity regions on T2-weighted and FLAIR MRI or increased 18F-GE180 uptake
there was no clinical difference between HLA-matched and non-matched patients
further confirmation through long-term follow-up and post-mortem histological examinations is necessary for definitive conclusions
PD08) in this trial exhibited motor symptom improvements exceeding what could be attributed to placebo responses
potentially due to DA synthesized by the graft
This interpretation should be further validated through post-mortem histological examinations in the future
younger patients with less severe symptoms appear to be more suitable candidates for this treatment
refining patient eligibility criteria may enhance the efficacy of this treatment
discrepancies were noted between the MDS-UPDRS part III scores and the Hoehn–Yahr stage
The Hoehn–Yahr stage emphasizes postural instability and mobility issues
whereas the MDS-UPDRS part III offers a more comprehensive evaluation of major motor symptoms in PD
improved postural stability and mobility may account for the greater improvement in the Hoehn–Yahr stage compared with changes observed in MDS-UPDRS part III scores of this study
which may have contributed to symptom improvement
there was no difference in adverse events between low- and high-dose groups
and neither graft overgrowth nor GIDs were observed
implanting more cells across a broader area may be necessary to achieve more substantial therapeutic effects
The favourable safety profile observed in this trial provides an opportunity to explore whether a higher dose across a wider region can offer greater clinical efficacy
Although our results did not fully align with age-related findings
it is notable that the worst case (PD05) was the oldest patient
These latter factors may partially explain the variable clinical responses observed in this trial
susceptible to influence from the placebo effect and physician bias
Future studies should consider a double-blind
placebo-controlled design to minimize these biases
small-sample trial should be confirmed in multi-centre
large-sample trials with appropriate controls
autologous transplantation using iPS cells may also be a promising option
in which a single treatment with tacrolimus effectively suppressed immune response during xenotransplantation
Histological examinations from previous fetal cell transplantation cases have shown that grafted DA neurons survived for 9 to 16 years
even with immunosuppression discontinued 6 to 18 months after transplantation
tacrolimus treatment was discontinued at 15 months
and a single MCB vial was thawed to induce DA progenitors for each patient
Human iPS cells were maintained with StemFit AK03N media (Ajinomoto) on iMatrix-coated (Matrixome) six-well culture dishes
Aggregate spheres were fixed with 4% paraformaldehyde
Immunostaining was performed after incubation with an antigen retrieval reagent (LSI Medience) and blocking with 0.3% Triton X-100 and 2% donkey serum for 1 h
Fluorescence images were obtained by using confocal laser microscopes (Fluoview FV1200
The antibodies used are described in the ‘Animal experiments’ section below
Clinical data were collected by using EDMS-Online (v.3.1
Safety and efficacy outcomes were summarized using mean values
Statistical analyses of the clinical data were conducted using SAS software (v.9.4
Statistical analyses of animal experiments were performed using GraphPad Prism (v.10.3.1
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article
All relevant data from this trial are included in the Article and Supplementary Methods. Source data are provided with this paper
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson’s disease
Dopamine release from nigral transplants visualized in vivo in a Parkinson’s patient
Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson’s disease
Transplantation of embryonic dopamine neurons for severe Parkinson’s disease
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease
The future of stem cell therapies for Parkinson disease
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
Personalized iPSC-derived dopamine progenitor cells for Parkinson’s disease
Preclinical efficacy and safety of a human embryonic stem cell-derived midbrain dopamine progenitor product
and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease
Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
MDS clinical diagnostic criteria for Parkinson’s disease
A more efficient method to generate integration-free human iPS cells
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population
Kinetic analysis of the translocator protein positron emission tomography ligand [(18)F]GE-180 in the human brain
The unified dyskinesia rating scale: presentation and clinimetric profile
Movement Disorder Society—sponsored revision of the Unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results
Systematic review of levodopa dose equivalency reporting in Parkinson’s disease
Levodopa dose equivalency in Parkinson’s disease: updated systematic review and proposals
Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson’s disease
A detailed account of methodology and a 6-month follow-up
Grafts of fetal dopamine neurons survive and improve motor function in Parkinson’s disease
Dyskinesias following neural transplantation in Parkinson’s disease
Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys
Graft-induced dyskinesias in Parkinson’s disease: what is it all about
Serotonergic neurons mediate dyskinesia side effects in Parkinson’s patients with neural transplants
Graft-induced dyskinesias in Parkinson’s disease: High striatal serotonin/dopamine transporter ratio
Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study
Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate
MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson’s disease
The placebo response in double-blind randomised trials evaluating regenerative therapies for Parkinson’s disease: a systematic review and meta-analysis
Expectation and dopamine release: mechanism of the placebo effect in Parkinson’s disease
Exenatide and the treatment of patients with Parkinson’s disease
Rate of clinical progression in Parkinson’s disease
Delayed recovery of movement-related cortical function in Parkinson’s disease after striatal dopaminergic grafts
Progression of monoaminergic dysfunction in Parkinson’s disease: a longitudinal 18F-dopa PET study
Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study
Rate of progression in Parkinson’s disease: a 6-[18F]fluoro-l-dopa PET study
Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports
in Recent Developments in Parkinson’s Disease Vol
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography
Estimation of nuclear population from microtome sections
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We thank all of the patients who participated in this trial; Y
Togashi for brain imaging; members of the Efficacy and Safety Evaluation Committee
Toda for their advice; doctors and coordinators at the Institute for Advancement of Clinical and Translational Science (iACT)
Toyooka for supporting this clinical trial; the technical staff of J.T.’s laboratory
Baba for cell manufacturing; PD project members of Sumitomo Pharma
Karino for regulatory support and cell manufacturing; and K
This study was supported by a grant from the Research Project for Practical Application of Regenerative Medicine of the Japan Agency for Medical Research and Development (AMED) (23bk0104126h0003) to J.T
These authors contributed equally: Nobukatsu Sawamoto
Kyoto University Graduate School of Medicine
Center for iPS Cell Research and Application
Department of Diagnostic Imaging and Nuclear Medicine
Department of Biomedical Statistics and Bioinformatics
and Takayuki Kikuchi wrote the first draft of the paper
contributed to the acquisition of clinical data
contributed to the generation of human iPS cells and DA progenitor cells
contributed to immunosuppressive therapy management
All of the authors contributed to the analysis or interpretation of data and performed critical revisions of the manuscript
received a grant for collaborative research from Sumitomo Pharma
received a research grant from Nihon Medi-Physics
received a research grant from Siemens Healthcare
The other authors declare no competing interests
Nature thanks David Devos, Hideyuki Okano and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
intermediate cells (before CORIN-positive cell sorting)
iPSCs and intermediate cells each form a distinct cluster
while final products are divided into two clusters
Relative proportions of cell types in each cell sample
determined by K-means clustering of sc-RT-qPCR data
indicate the final product consists of approximately 60% DA progenitors and 40% DA neurons
Batch #20022 was the donor cells used for PD04
Violin plots of gene expression patterns in clusters of iPSCs
and final products show gene expression changes during DA differentiation
Violin plots of gene expression patterns across different batches of final products indicate stable expression among batches
Source data
Immunofluorescence images of donor cells on day 30 (n = 7 independent experiments)
NURR1 (a) is a nuclear receptor expressed in DA neurons
while FOXA2 (b) is a transcription factor expressed in the floor plate
The merged image (d) shows that donor cells consist mainly of DA progenitors and some DA neurons
Summary of cell transplantation experiments and results
Low- and high-dose cell injections were administered to examine differences in cell survival and behavioural improvement
Methamphetamine-induced rotation behaviour in rats with grafts shows improvement at approximately 24 weeks
*** p < 0.001 versus vehicle group by a two-way analysis of variance (ANOVA) with Tukey’s multiple comparisons test
Adjusted p value = 0.033 (20 weeks) and 0.045 (24 weeks)
a marker for DA neurons) in representative grafts at 32 weeks (n = 4 independent experiments)
Magnified image of the graft shown in panel j
Immunofluorescence image of the graft double-labelled for TH and HNA-positive cells indicating donor-derived DA neurons (n = 4 independent experiments)
Percentage of KI67-positive cells relative to HNA-positive cells for each graft
and 9 (batch 21047) biologically independent animals
Immunofluorescence image of the graft stained for HNA (green) and KI67 (red)
Magnified image of the graft shown in panel n
with an arrowhead indicating an HNA/KI67 double-positive cell
Immunofluorescence image of the graft stained for HNA (green) and 5-HT (red)
Magnified image of the graft shown in panel p
showing the absence of HNA/5-HT double-positive cells
Immunofluorescence image of the host Raphe nucleus as a positive control for serotonergic neurons (5-HT
red) DAPI staining is shown in blue (n = 4 independent experiments)
Source data
and sagittal images are displayed from top to bottom
Blue and yellow regions indicate areas within 3 mm of cell injection sites
Changes in graft volume as measured by T2-weighted MR images of each patient
Hyperintense areas within the blue and yellow regions were calculated (R: right and L: left)
Source data
The Hoehn and Yahr scale was evaluated at 3
“ON” indicates measurements taken while the patient was on medication
while “OFF” indicates measurements taken after the patient had been off medication for more than 12 h
Source data
Chronological changes in LEDD for each patient from registration (0 M) to the end of the observation period (24 M)
Absolute and relative (percentage) changes at 24 months are shown on the right
Source data
a, Chronological changes in the fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) Ki values for each side of the putamen for each patient from registration (0 M) to the end of the observation period (24 M), as a supplement to Fig. 3
semiquantitative 18F-DOPA images generated at 80–90 min post-injection by subtracting the occipital background signal and normalizing the result to the occipital activity for each patient (Pre-Op: pre-operation
reflecting dopamine synthesis by grafted cells
Relationship between 18F-DOPA uptake and motor symptom improvement
(i) Plots of pre- and post-transplant Ki values and MDS-UPDRS part III OFF scores for six (PD02-08) patients
Healthy and initial symptom ranges are indicated based on previous studies
where Ki values for healthy individuals range from 0.010 to 0.017
and initial Parkinsonian symptoms emerge with Ki values between 0.0045 and 0.0073
(j) Changes in Ki values and MDS-UPDRS part III OFF scores for each patient
Source data
Supplementary Methods and Supplementary Tables 1–7
Detailed protocol for an investigator-initiated clinical trial of safety and efficacy of transplantation of human iPS-cell-derived dopaminergic progenitors for Parkinson’s disease
Detailed plan for an investigator-initiated clinical trial of safety and efficacy of transplantation of human iPS-cell-derived dopaminergic progenitors for Parkinson’s disease
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DOI: https://doi.org/10.1038/s41586-025-08700-0
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By Greg Waldron2025-05-05T08:44:00+01:00
Norway has received US government approval to acquire up to 300 Raytheon AIM-9X Block II tactical missiles
The potential package is valued at $371 million and includes the missiles
as well as other equipment and services related to the acquisition
according to the US Defense Security Cooperation Agency (DSCA)
An AIM-9X on the wing-tip pylon of a US Navy F/A-18 Super Hornet
“This proposed sale will support the foreign policy goals and national security objectives of the United States by improving the security of a NATO Ally that is a force for political stability and economic progress in Europe,” says the DSCA
“The proposed sale will improve Norway’s capability to meet current and future threats by ensuring aviation forces’ interoperability with the United States and other NATO members
Norway will have no difficulty absorbing these weapons into its armed forces.”
The AIM-9X Block II offers considerable advantages over the previous Block I
the ability to lock onto a target after launch
and a datalink that can provide mid-course updates
The AIM-9X Block II approval comes just under one year after Norway was cleared to obtain 300 Raytheon AIM-120C-8 Advanced Medium-Range Air-to-Air Missiles
Norway has received 52 Lockheed Martin F-35As
the weapon can be used by the National Advanced Surface-to-Air Missile System
which was jointly developed by Kongsberg and Raytheon.
The US Air Force (USAF) is looking for new options for air-to-air missiles
In a sweeping overhaul of the service’s force structure
senior Pentagon officials have directed the US Army to end procurement of “obsolete” and “outdated” aircraft platforms
including the Boeing AH-64D and General Atomics MQ-1C Gray Eagle uncrewed aerial vehicle
The US government has cleared the possible sale of Raytheon AIM-120 Advanced Medium-Range Air-to-Air Missiles (AMRAAMs) to Poland
The troubled Boeing T-7A advanced jet trainer programme has taken a step forward with a successful test of its new escape system
The California company Stratolaunch is pioneering the development of a reusable flight vehicle capable of reaching speeds beyond Mach 5
Ten of the Boeing refuellers have been listed for sale on a US government auction website
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argued that the moment demands a spiritual leader who can resist the pressures of authoritarian regimes
“[T]he Church needs a 21st-century version of St
She pointed to Nicaragua as one of the starkest examples of modern-day religious oppression
President Daniel Ortega has escalated a years-long campaign against the Catholic Church
and eliminating public religious expression.
Ortega appears to be taking cues from the Vatican’s 2018 accord with Beijing
which gave the Chinese Communist Party a decisive role in the selection of bishops.
>> China appoints new bishops during ‘sede vacante,’ defying Vatican agreement <<
“Apparently [Ortega] thinks if he turns up the heat high enough he can get a similar deal,” O’Grady wrote
She warned that such an outcome wouldn’t remain isolated.
Cuba and Venezuela will expect one too,” O’Grady wrote
“What better way to eliminate the independence of one of the few institutions still standing among the ruins of democracy?”
O’Grady contrasted this approach with the example set by Pope John Paul II
moved away from the Church’s mid-20th-century diplomatic posture toward communist regimes
emphasized quiet negotiation over confrontation
often trading silence on persecution for limited operational freedoms.
a survivor of both Nazi and Soviet oppression in Poland
he ignited a movement that helped dismantle communist rule across Eastern Europe
O’Grady referenced John Paul II’s biographer George Weigel
who explained that Pope John Paul II’s strategy “ended the anti-communist rhetoric that had characterized [Vatican] public diplomacy in the 1950s
removed several senior churchmen who refused to concede anything to communist governments,” and discouraged both exiled Catholic leaders and underground resistance
“conducted a vocal human rights campaign that was instrumental in igniting the revolution of conscience that shaped the revolution of 1989 and the self-liberation of east central Europe from communism.”
authoritarian regimes have targeted the Catholic Church through intimidation
clergy were expelled and public worship suppressed for decades; in Venezuela
bishops who opposed socialist abuses have faced significant retaliation; and in Nicaragua
Venezuelan and Nicaraguan Catholics have put it all on the line in defense of their brethren and in the name of human dignity,” she said
“They need a pope who will back them unequivocally
as John Paul II once did for the people of Eastern Europe.”
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