Open image viewerThe timber structures found were analyzed using radiocarbon dating Image: Jan FastYle News3.11.2023 18:36Timbers uncovered during excavations last spring at the site of the ramparts of the old Korsholm Castle in Vaasa (also known as Chrysseborg) have turned out to be the remains of a fortress built in the middle of the 14th century at time when Finland was a part of the Kingdom of Sweden a public education and culture organisation in Ostrobothnia says that scientific confirmation of centuries-old theories and stories about the existence of the fortress was received with a real sense of excitement Korsholm Castle was first founded in the middle of the 14th century so this confirms the theory very well," she explains Korsholm Castle was first mentioned in a written record during the latter part of the century in the will of its warden Bo Jonsson Grips Five samples were taken from the excavated timbers which were sent for examination first to Denmark and then to Sweden "Jutland's Moesgaard Museum confirmed pine as the wood species We would have been surprised by the other result but it's good that it was confirmed," says Hummelstedt Open image viewerThe ramparts of Old Vaasa Vaasa was leveled in a fire in 1852 and the city was rebuilt some seven kilometres away from its original site Image: YA/Kim Blåfield.Radiocarbon dating at the University of Uppsala determined that one of the samples dates from the middle of the 14th century The other four samples date to between 1450 and 1650 a period during which Swedish King Gustav Vasa had a royal estate constructed in the area The discovery has spurred interest in continuing and expanding the excavations on the castle mound Users with an Yle ID can leave comments on our news stories. 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You can comment on this article until 23:00 on 4 November. with the appointment of six world-class experts who will play a key role in the global expansion of the fast-growth firm launched by Christian Frahm to help banks hedge funds and asset managers to accelerate their transition to a digital world through access to fintechs specialising in capital markets Russel Levi – 25 years’ experience heading up Sales at Bloomberg and SuperDerivatives; responsible for building Bloomberg’s European business Michel André – CTO at Saxo Bank for 14 years and widely regarded as one of Europe’s leading IT architects Rasmus Jensen – Specialist in corporate leadership and digital transformation instrumental in the significant growth of Templafy’s commercial team former partner at EQT and 12 years at the firm which is one of Europe’s most successful Private Equity firms with $80 billion AUM Jannik Kruse Petersen – 20 years in investment banking and private equity and a successful private fintech investor Head of Capital Markets and M&A at Bruun Hjejle advising clients such as Goldman Sachs and EQT Jannik Kruse Petersen and Morten Jensen are also investors in United Fintech “We have strengthened our exceptional team with an outstanding Advisory Board to provide further scrutiny and consultancy particularly in terms of our strategic fintech acquisitions Our Advisory Board comprises of world class leaders in their respective fields including highly experienced and talented M&A experts and fintech leaders such eminent experts have chosen to support our vision and join our journey.” “I am excited and feel privileged to be part of such a talented and experienced Advisory Board The capital markets industry largely runs using legacy technology and data provided by a small number of outdated providers with inflexible and expensive business models The status quo is ripe for disruption by nimble start-ups with strong engineering credentials “Christian is an incredibly ambitious and successful visionary and has established United Fintech with a clear plan to enable banks and hedge funds worldwide to have easy access to innovative capital markets solutions and to help proven but small fintechs accelerate their growth globally and realise their true potential.” United Fintech has stated that it plans to acquire and scale a range of pioneering small to medium-sized engineering-led fintech companies all with a proven capital markets product; and to partner with banks and financial institutions to help them to access and onboard these innovative digital technologies To date, the firm has acquired two fintech firms, NetDania and TTMZero and plans to have an extensive fintech portfolio including products ranging from trading platforms liquidity management and regulatory reporting tools through to AI and machine learning applications United Fintech has grown at a rapid pace and now employs 85 people in London Its team consists of world-class experts in each aspect of building growing and scaling capital markets businesses Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" With FNG's Newsletter you'll get all the latest breaking FX Industry news stories - in a concise daily email Get FNG's daily newsletter to receive notice of all articles like this one The nucleolus is essential for protein production and regulation of cell growth High nucleolar activity in cancerous cells supports rapid cell growth and inhibition of nucleolar activity can induce cell death in cancer cells The nucleolus therefore offers an attractive target for development of novel anti-cancer treatments Due to the high cellular demand for protein the rDNA is the most active genomic region and each cell is estimated to have around 400 copies of the ribosomal RNA genes The rDNA is an intrinsically unstable region of the genome and one of the most frequently rearranged parts of the genome in cancers The Nucleolar stress and disease group aims to reveal the molecular mechanisms that maintain and protect the rDNA The study of DNA damage in specific genomic regions has been technically challenging in the past but the discovery of CRISPR/Cas9 technology provided new opportunities as it allows site-specific induction of DNA breaks a technique that is used and continuously developed in the lab (Korsholm et al. we can create nucleolar DNA damage recognized by NBS1-GFP and we can quantify rDNA repair by measuring GFP-intensity in the nucleolus (See Figure 1A and B) One of our aims is to uncover novel pathways protecting rDNA integrity For this purpose we use high-throughput imaging screens proximity labelling techniques and mass spectrometry analysis We analyse the consequences of defects in the nucleolar DNA damage response ribosome biogenesis and genome instability high-content imaging and superresolution microscopy We also investigate how inhibition of newly identified rDNA repair proteins can be used for cancer treatment A second aim is to develop nucleolar biomarkers to improve treatment of cancer patients We are developing methods to assess nucleolar status in cancer patients to further understand how increased nucleolar activity promotes cancer development and influence the outcome of currently used cancer treatments The nucleolar DNA damage response The nucleolar DNA damage response is unique and in addition to break detection signalling and repair it also involves transcriptional silencing and a prominent restructuring of the nucleolus that leads to accumulation of rDNA at the nucleolar periphery in so-called nucleolar caps (See Figure 1B).We have conducted high-throughput screens (using siRNA libraries and proximity-based labelling techniques) to identify new proteins that control this process We are currently characterizing candidate proteins to determine their individual roles in the nDDR and to determine their anti-cancer potential.Mutations in several well-characterized DDR proteins lead to hyper-instability of rDNA By depletion and knock out of such DDR proteins we also study mechanisms maintaining rDNA stability and the faulty mechanisms that become activated in their absence and lead to rDNA destabilization The nucleolus and cancer Nucleolar activity is upregulated in almost all cancers and altered nucleolar morphology is a characteristic of cancer Despite this our understanding of nucleolar dysregulation in cancer and its clinical use is very limited We aim to establish methods that will enable evaluation of nucleolar status in cancer patients and thereby allow new investigation of its predictive and/or prognostic value Treacle is Upregulated in Cancer and Correlates With Poor Prognosis Treacle Sticks the Nucleolar Responses to DNA Damage Together Recent advances in the nucleolar responses to DNA double-strand breaks Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair PubMed PMID: 31184714; PubMed Central PMCID: PMC6735822 The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage PubMed PMID: 25064736; PubMed Central PMCID: PMC4962910 Dorthe Helena Larsen leads the Nucleolar Stress and Disease Group She has a strong background in molecular biology with a deep interest in the cellular response to DNA damage Larsen received her PhD degree from the University of Copenhagen in 2009 for her research conducted at the Danish Cancer Society During her PhD-studies she worked in the laboratory of Professor Jiri Lukas and Professor Jiri Bartek on identification of novel DNA repair proteins Larsen continued her postdoctoral studies at the University of Zurich in the lab of Professor Manuel Stucki and as a visiting researcher at the Novo Nordisk Center for Protein Research where she identified a protein complex that regulates nucleolar function after DNA damage Larsen started the Nucleolar Stress and Disease Group at the Danish Cancer Society that focuses on DNA repair of the ribosomal RNA genes In 2018 she received the prestigious starting grant Sapere Aude from the Independent Research Fund Denmark ORCID: 0000-0002-8280-1252 Contact information for all staff in NSD Sapere Aude Starting Grant, Independent Research Fund Denmark We only accept applications through our recruitment system 1.6.2021 08:57:17 CEST | Bellagroup A/S | Pressemeddelelse led by an experienced group of investors has offered to continue the development of BC Hospitality Group (BCHG) An increased cash position will give BCHG a chance to come out of the corona crisis and act on new growth opportunities When the plans are confirmed at the Annual General Meeting the group will continue on solid financial ground.At the upcoming Annual General Meeting on June 15 the board of directors and a majority of the current owners will recommend a directed share issue of BC Hospitality Group to a new danish group of owners led by former Senior Partner and Global Leader of Travel Transport & Logistics Sector in McKinsey & Co. as well as former COO of ISS with international experience from the service and hospitality sector The share issue will be undertaken with support from Danish public growth fund Danish syndicate looks forward to the continued development of BC Hospitality Group with its congress & exhibition center Bella Center Copenhagen and hotels is crucial for Copenhagen to continue attracting larger congresses and events as well as tourists creating economic activity and jobs We have gathered a team of investors with relevant expertise from the hospitality sector and we all see an opportunity for BCHG to move out of the corona crisis stronger than ever,” says Christian Riis-Hansen on behalf of the syndicate “We are improving the group’s cash position so that we have a solid and healthy financial launch pad for the continued positive development of BC Hospitality Group after corona We believe that there is a strong team leading the company and we see a big unresolved potential in the core business as well as in the potential for future expansion,” says Christian Riis-Hansen It has been pivotal for the agreement that the day-to-day operation of Bella Center Copenhagen as well as the hotels will continue as planned The change of ownership will not affect customers will continue as permanent CEO of BC Hospitality Group Chairman: The future development of the group has been secured “We feel a big responsibility to our employees and all of our customers who have postponed events with us or booked hotel visit and conferences in the months ahead We are happy that it was possible to find a new Danish group of owners who can continue the development of BCHG,” says the current chairman of the board The agreement is to be finally approved at the Annual General Meeting Head of Press - BC Hospitality Group Karen Østerbye - kars@bchg.dk - +45 81884843 BC Hospitality Group is one of Denmark's largest hotel 162 meeting and conference rooms and approximately 200,000 square metres of conference meeting and event facilities with a total capacity in excess of 30,000 people BC Hospitality Group comprises Bella Center Copenhagen BC Hospitality Group's new and in total14,000 square meters new multi hall and part of Bella Cener Copenhagen will be finished during first half of 2021 ready to house everthing from concerts and other cultural events to congresses and exhibitions og følg instruktionerne i den udsendte e-mail AC Hotel Bella Sky og Crowne Plaza Copenhagen Towers has reached a significant milestone in its sustainability journey: an official approval of the company’s climate targets by the Science Based Targets initiative (SBTi) This places Bellagroup among an exclusive group of companies in the hospitality sector that have had their CO2e reduction targets validated according to the strictest scientific standards Copenhagen Gaming Week debuted in January 2024 the festival can rightfully call itself Denmark’s fastest-growing event for gaming and broader gaming culture with a total of 23,000 gaming enthusiasts gathering at Bella Center Copenhagen from February 13th to 15th Copenhagen and Denmark are now attracting so many tech talents and investors that Scandinavia's largest tech and startup event anticipates solid growth in the coming years TechBBQ has agreed with Bella Center Copenhagen to host an event with 10,000 participants in 2025 The long-term goal is to transform Denmark and the Nordics into an entrepreneurial hub Bellagroup broadened its sustainability focus in 2023 The hospitality company is now a quarter of the way towards being net zero by 2050 after just four years Simultaneously Bellagroup has implemented new climate measurement initiatives and secured a certification within several ISO standards Now a B Corp certification process awaits along with efforts to involve customers and suppliers more deeply in the company’s ESG initiatives Scandinavia’s leading international congress and exhibition venue announces the launch of an ambitious climate reporting initiative setting a new standard for sustainability in the global events industry I vores nyhedsrum kan du læse alle vores pressemeddelelser tilgå materiale i form af billeder og dokumenter samt finde vores kontaktoplysninger.