LE PONT-DE-CLAIX, France, Sept. 18, 2024 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX) a leading global medical technology company announced the commercial release of the BD Neopak™ XtraFlow™ Glass Prefillable Syringe and the latest capacity expansion of the BD Neopak™ Glass Prefillable Syringe platform to serve the growing market for biologic therapies The BD Neopak™ Glass Prefillable Syringe platform is designed to address key development needs for biologic drugs and our customers have received approval to utilize this platform for more than 24 indications cardiovascular disease and various rare diseases BD has expanded usability of this platform with the commercial release of the BD Neopak™ XtraFlow™ Glass Prefillable Syringe This solution features an 8-millimeter needle length and thinner wall cannula to optimize subcutaneous delivery of higher viscosity drug profiles by reducing the injection force and time required for a fixed solution viscosity1,2* This improvement allows pharmaceutical developers to break design barriers enhancing flow and usability beyond today's limits versus a standard half-inch needle3* "BD is seeing significant growth in the biologics segment driven by novel drug formulations across indications such as metabolic disorders and oncology," said Patrick Jeukenne "With over 30 drugs approved across 12 markets and many more in development with the BD Neopak™ Glass Prefillable Syringe platform As a global leader in prefillable drug-delivery systems BD aims to evolve as rapidly as the global biologics pipeline to enable supply and delivery of these drugs for patients worldwide." our manufacturing site in Le Pont-de-Claix France has successfully integrated a high-volume manufacturing line for the BD Neopak™ Glass Prefillable Syringe platform increasing the production capacity of a single line by sevenfold4 This achievement marks a significant milestone for BD enabling unprecedented large-scale production of advanced BD glass syringes The launch of our BD Neopak™ XtraFlow™ Glass Prefillable Syringe allows developers to take advantage of a single platform approach while dismantling existing design barriers such as drug viscosity The successful addition of the high-volume line at the Pont-de-Claix site allows BD to be more resilient to supply constraints and further demonstrates our commitment to continuously evolve to meet the needs of our pharmaceutical partners and patients worldwide These expansions add to BD's leadership in offering a broad range of injection solutions to enable delivery of treatments such as GLP-1s and other next generation treatments for chronic disease This press release contains certain forward-looking statements regarding the BD Neopak™ Glass Prefillable Syringe platform Forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements challenges inherent in product development including the development of new technologies or products by other companies or other factors listed in BD's 2023 Annual Report on Form 10-K and other filings with the SEC BD expressly disclaims any undertaking to update any forward-looking statements set forth herein to reflect events or circumstances after the date hereof except as required by applicable laws or regulations Media:                                                  Fallon McLoughlin                  Public Relations         201.258.0361                                  201.847.6927        [email protected]               [email protected]     Injection time and ejection force calculation [internal study] BD NeopakTM XtraFlowTM 2.25 mL prototype evaluation [internal study] 3. Pager et al. (2020), "User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with staked 8 mm ultra-thin wall needle", Expert Opinion on Drug Delivery, https://doi.org/10.1080/17425247.2020.1796630 *When compared to 12.7 mm special thin wall needle today announced 510(k) clearance from the U.S has launched a new advanced hemodynamic monitoring.. Health Care & Hospitals Medical Pharmaceuticals Medical Equipment New Products & Services Do not sell or share my personal information: Built on the Grands Moulins de Villancourt heritage site in France the contemporary Centre de sciences Cosmocité aims to be the cultural cornerstone of Ville de Pont-de-Claix’s urban renewal Architects Jean-Yves Guibourdenche and Jean-François Julien have unveiled their design for the new Centre de sciences Cosmocité, which has opened in Pont-de-Claix, a commune in the Isère department in southeastern France In line with the museum concept developed by scenographer CREO and in close collaboration with cultural centre La Casemate and the wider scientific community the building aims to preserve the memory of the Grands Moulins de Villancourt site an important part of  the municipalities of Echirolles and Pont-de-Claix in the 19th and 20th centuries Taking up the exact layout of the demolished building the architects created two distinct volumes – one rectangular white volume and a sweeping black curve – link the region’s industrial past with the contemporary scientific focus of the new institution The glossy white section of the building houses the passageways and related spaces, while the centre’s opaque black volume houses spaces dedicated to the dissemination of scientific content: the planetarium immersion room and permanent exhibition hall Finding inspiration in the universe’s great mysteries and humankind’s place in the cosmos and mysterious quality invites onlookers to reflect the vertical and horizontal corridors are bathed in natural light and offer views of the surrounding landscape the circular planetarium is inclined at 10° including 4 for people with reduced mobility and provides a 360° view of a semi-spherical screen The architectural team called on the Montreal-based digital studio CREO to create the Cosmocité scenography To meet the numerous requirements of this ambitious project CREO put together a multidisciplinary design team who worked in close collaboration with the project’s Grenoble-based scientific committee as well as with Centre de Culture Scientifique Cosmocité’s highly interactive exhibition is designed to answer fundamental questions such as: Is the Earth unique from the birth of stars to the causes of earthquakes Get a curated collection of design and architecture news in your inbox by signing up to our ICON Weekly newsletter It didn’t take too long for Ciccone to get back on track the race to get some feedback on the road to the Tour de France after more than a month away from racing… well Giulio won the final stage of the French race with a show of strength as he already did earlier in the season at Volta Valenciana and Volta Catalunya he faced the challenge of getting in the breakaway with riders like Alaphilippe and Benoot (just to name a couple) Ciccone made his performance stronger and stronger leaving a maximum advantage of only 2’30” the breakaway lost protagonists and actors when Giulio broke the tie and went on a solo mission A challenge of one against all: Vingegaard Cicco kept the distance and the last ramp up to Grenoble La Bastille (2km at an average of 14%) was the springboard to the finish line where he celebrated his third win of the season and winning before the Italian Championships and the appointment for the second Grande Boucle of his career The final 500 meters of today’s stage were really long but with all the people there it was really nice when I looked behind and saw I was still in front with a good gap I just went full gas straight and I’m really happy It was really difficult all day because the guys behind kept the gap really small it was not easy from the start to the finish I took some risks in the last downhill and on the final climb I just pushed full gas knowing that the finish line was just there the Giro was in my program and then I got covid just before I had to skip that and then had about 10 days off the bike but I started here with the Tour in my mind and this week I could see I was getting better and better Campenaerts was with us in the breakaway and took his points The Tour de France is now really close but before that I get married next week and this is a gift for my future wife I really would like to win one stage in the Tour and I really like this jersey so we go there and stay focused and see day by day The TFR XC women were named the Best Team in Lenzerheide The architectural consortium comprised of ARCANE Architectes (France) and Cardin Julien (Canada) is delighted to unveil the new Centre de sciences Cosmocité built on the Grands Moulins de Villancourt heritage site in Pont-de-Claix conceived by architects Jean-Yves Guibourdenche and Jean-François Julien is in line with the museum concept developed by scenographer CREO in close collaboration with La Casemate and the scientific community Cosmocité aims to preserve the industrial memory of the Grands Moulins de Villancourt site which was an important part of the industrial and human heritage of the urban agglomeration and the municipalities of Echirolles and Pont-de-Claix in the 19th and 20th centuries With its location at the municipality's northern entrance Cosmocité is the cultural cornerstone of Ville de Pont-de-Claix's urban renewal The commissionTaking up the exact placement layout of the demolished building the architects created an assemblage of volumes that link the region's industrial past with the contemporary scientific focus of the new institution embodied by the black volume glossy white volume houses the passageways and related spaces while the matte and opaque black volume houses all  spaces dedicated to the dissemination of scientific content: the planetarium Recalling the universe's great mysteries and humankind's place in the cosmos and mysterious quality invites onlookers to fathom its scale The volumetric design reflects the building's function and contributes to the site's global message: science that's welcoming and open to all The programCosmocité houses:- An 80-seat planetarium The role of a planetarium is to teach and popularize astronomy and space science for both school and family audiences.- A permanent tour based on two themes: “EARTH” and “COSMOS” with interactive floor and wall screens- A 14-metre-high Foucault pendulum- A variable activity space: children/youth audience area and a modular room- Additional facilities: reception and logistics- A roof terrace overlooking the Grenoble basin and its surrounding mountains- The facility is designed to welcome around 57,000 visitors per year The planetariumCircular and inclined at 10° the space can be accessed via a vision adaptation waiting area and an acoustic airlock providing a 360° view of a semi-spherical screen It is lined with a circular technical gallery and a data centre The permanent exhibitionThe architectural team called on the Montreal-based digital studio CREO to create the Cosmocité scenography who worked in close collaboration with the project's Grenoble-based scientific committee Cosmocité's highly interactive exhibition is designed to answer fundamental questions such as: Is the Earth unique it covers everything from the birth of stars to the causes of earthquakes a 14-metre-high Foucault pendulum spans the building to demonstrate the Earth's rotation A bioclimatic designThe building has been designed to balance the space of the west-facing garden with that of the eastern forecourt The hall and staircase are glazed to capture free energy from the sun and to encourage the public to use the staircase to climb to the upper floors this solar energy is controlled by screen-printed glass to prevent overheating the building opens onto the garden and the Vercors landscape while the cantilevered planetarium hall shelters it from the summer sun Interior characteristicsThe acoustic comfort has been carefully studied to avoid any sound transfer between spaces Summer thermal comfort is ensured by:- A heat inert cement structure;- Efficient solar protection: 50% screen-printed glass on the east facade and external solar shading;- Openings for natural ventilation;- Air quality is ensured by a double-flow system Energy optimizationEnergy efficiency is primarily about reducing the building's thermal requirements which is made possible via a compact construction and a high-performance envelope The building's main structure is in reinforced concrete which is insulated from the outside to eliminate thermal bridges and the associated risk of condensation and to benefit from an inertia conducive to summer comfort The building envelope's performance has been designed to be well below the French regulatory threshold in terms of energy requirements Heating is provided by way of a district heating system an urban stone forecourt accommodates the varying flow of visitors drawn to this site and its activities a garden and its outdoor amphithéâtre form a buffer zone between the parking lots and the Centre de sciences a conserved hundred-year-old cedar tree serves as a reminder of the city's continuing renewal Direction/cultural and scientific programming: La Casemate Scientific curator: UGA / CNRS / OSUG Construction cost: 6 732 000 € HT Architecture ARCANE Architectes and Cardin Julien Engineering Mechanical-electrical engineering: CET Bâtiment & Energie [AK1] [ÉP2]  Structural and economy: BETREC I.G Scenography CREO François Tourny (engineer) Specialists Immersive room and Planetarium: RSA Cosmos / Theoriz Environmental quality: Etamine Road works and various networks: MTM Infra Acoustics: Echologos ARCANE Architectes is a resolutely generalist firm with the ability to respond to operations on all scales in both the private and public sectors Based in Grenoble since its founding in 1986 its strength resides in its talented and creative team which supports its clients at every stage of the building process Backed by a wealth of experience in both new construction and restoration the firm is renowned for its rigorous approach to deadlines Each project is conceived as a unique adventure driven by creativity and innovation and always carried out in a sustainable and resource-efficient manner Among ARCANE's finest achievements are the Palais des Sports et des Congrès in Megève (France the Centre de sciences Cosmocité in Le-Pont-Claix (France and the Arboréa multiple-unit dwelling program in Pringy (France) for which it was awarded the Grand Prix Régional des Pyramides d'Argent 2022 About Cardin JulienFounded in Montreal in 1992 Cardin Julien is an architecture firm that conceives and produces major projects in the public and private sectors The firm specializes in the design of public and cultural buildings serving the community Guided by the principles of sustainable development the group proposes distinctive designs that are in harmony with their surroundings the firm aims to leave an impression on both minds and hearts Following its success in several architectural competitions Cardin Julien has carried out several major cultural projects such as the Rio Tinto Alcan Planetarium in Montreal (with Aedifica) the Planétarium du Jardin des sciences at Université de Strasbourg (with frenak+jullien and m+ mathieu holdrinet) and Centre de sciences Cosmocité in Grenoble (with ARCANE Architectes).Cardin Julien's mission is to co-create to reveal the full potential of your ideas and to build places for better living.Media contacts France Amandine Kowalskiamandine.kowalski@arcane-archi.frTel: + (33) 4 76 03 27 27 Canada and Worldwide Etienne Proulxeproulx@cardinjulien.comTel: +1 514 272-6798 Drug Delivery Business November 16, 2021 By BD (NYSE:BDX) announced today that it broke ground on its $200 million pre-filled drug delivery device manufacturing plant in Spain Franklin Lakes, New Jersey-based BD announced in May that it would build the $201.5 million (€165 million) high-tech manufacturing facility in Zaragoza, Spain with expectations of creating up to 600 jobs at the facility by 2030 which will initially register a size of 86,000 square feet (8,000 square meters) with BD beginning the recruitment process to fill key positions supporting the design and set-up of the plant “These roles will be on the front lines of building a sustainable, state-of-the-art and fully digital site incorporating the latest in intelligent and autonomous solutions,” Thibault Naegelen, Program Director for BD’s Zaragoza facility, said in the release “We look forward to building a team in Zaragoza that helps BD meet its mission of advancing the world of health by supplying our European customers with devices that enhance drug delivery.” In December 2020, BD announced its intent to invest $1.2 billion over four years to expand and upgrade multiple drug-delivery facilities The company said it would open the new facility and build upon its six existing sites in Columbus The Zaragoza team will produce drug delivery devices mainly for biopharmaceutical companies supporting the European market with drugs in pre-fillable syringes including vaccines and other biologic drugs BD said the new facility will add much-needed capacity to support major vaccination campaigns going forward including the ongoing effort to vaccinate the world against COVID-19 The company is set to hire operators and production staff to oversee production lines closer to the opening date for the plant in 2023 BD intends to ensure that the site meets high sustainability and eco-efficiency standards and anticipates that the facility will employ up to 600 people with an area of 323,000 square feet (30,000 square meters) by 2030 “Pre-fillable drug systems are a known factor in helping health care providers effectively reliably and consistently administer drug therapies,” BD Pharmaceutical Systems Worldwide President Eric Borin said more than 70% of the top 100 biopharmaceutical companies rely on BD pre-fillable syringes This groundbreaking marks an important milestone in our ability to extend manufacturing capacity for our customers as they continue to grow their vaccine and biologic drug pipelines.” Sean Whooley is an associate editor who mainly produces work for MassDevice, Medical Design & Outsourcing and Drug Delivery Business News. He received a bachelor's degree in multiplatform journalism from the University of Maryland, College Park. You can connect with him on LinkedIn or email him at swhooley@wtwhmedia.com Copyright © 2025 · WTWH Media LLC and its licensors The material on this site may not be reproduced except with the prior written permission of WTWH Media Privacy Policy | RSS Our vision is to enable customer success with high quality and innovative drug delivery solutions that improve patient well-being we are empowering customer success through innovative drug-delivery solutions that improve patient quality of life Prefillable Syringes* (PFS) manufactured per year1 Products used by more than 500 Pharmaceutical and Biotechnology companies.2 BD customers include 27 of the top 30 pharmaceutical companies in the world.3 ~70% of the top 100 pharmaceutical companies around the world rely BD Medical-Pharmaceutical Systems prefillable drug-delivery systems for a wide variety of therapeutic applications.4 BD has generated over 4000 patents that are enforced in more than 25 countries.5 There is a patient at the end of each of the billions of drug delivery devices that we make at BD That is why we have invested in deep knowledge around patient experience injection science and combination product development to anticipate customer challenges We also invest heavily to support our commitment to quality Through our extensive global manufacturing network we aim to offer security of supply and business continuity to our customers plus our ability to leverage the industry and health authority partnerships of a global healthcare company are game changing advantages that BD brings to our customers’ drug delivery challenges We leverage these assets as we develop innovative solutions that provide peace of mind to customers and contribute to greater patient well-being Solutions to meet your needs across therapeutic areas BD Medical - Pharmaceutical Systems manufactures and sells prefillable drug delivery systems to pharmaceutical and biotech companies Featuring a comprehensive portfolio of innovative prefillable syringe systems BD offers drug delivery solutions designed to help decrease development risk and increase flexibility to meet patients’ needs across a wide range of drug types and therapeutic areas BD Safety & Shielding Systems provide pharmaceutical companies with a wide range of both active and passive manual injection solutions available in 0.5ml suitable for a variety therapeutic indications BD offers an extensive portfolio of patient centric self-administered drug delivery solutions including disposable autoinjectors and wearable injectors designed to deliver a wide range of volumes and viscosities and help de-risk combination product development we provide a complete set of components for your prefillable syringe systems BD Neopak™ XtraFlow™ Glass Prefillable Syringe BD Hypak™ for Vaccines Glass Prefillable Syringe BD UltraSafe Plus™ 1mlL Passive Needle Guard BD Sterifill Advance™ 50ml Polymer Prefillable Syringe BD Hypak™ for Biotech Glass Prefillable Syringe  BD Hypak Physiolis™ Glass Prefillable Syringe BD Uniject™ Auto-Disable Prefillable Injection System BD Physioject™ - recognized by the Arthritis Foundation® BD Libertas™ wins prestigious Good Design® Award Fill out our form to have one of our experts contact you  BD Customers compared to Evaluate Pharma ranking FY2019 IQVIA: IQVIA dataset extracted on March 11th from the IQVIA Smart MIDAS' on-line platform Top 100 Corporation (based on IQVIA standard units 2020) selling PFS  BDM-PS Patents – In force – Worldwide – October 2021 BD understands the drug development process and objectives at each stage and offers a wide range of services to help develop container/device strategy and life cycle management plan for drugs BD Pharmaceutical Services and Solutions are designed to help you achieve your combination product goals BD PartnerPath program™ supports the development of combination products with quick access to small quantities of preconfigured drug delivery systems We are committed to partnering for your sustained commercial success Quality is the foundation of customer and patient trust; it is at the core of what we do to provide safe All BD associates are committed to a culture of quality inspired by the customers and patients we serve View documents View documents View documents View documents View research articles published in a journal and written by experts sharing study results that offer you insight into a particular topic such as those used for display at BD tradeshows or seminars to provide detailed information on a research topic and technical information by viewing a brochure Visit the BD Medical - Pharmaceutical Systems webinar portal Watch a video to be educated about BD products or services View promotions or announcements for BD products and services BD Launches Next Generation Prefillable Vaccine Syringe Designed for Reliability BD Effivax™ Glass Prefillable Syringe Features Enhanced Technology that Builds on Company’s Decades of Expertise in the Prefillable Syringe Market and Supports Customers’ Manufacturing Needs FRANKLIN LAKES today introduced a next-generation glass prefillable syringe (PFS) that sets a new standard in performance for vaccine PFS with new and tightened specifications for processability BD and Mitsubishi Gas Chemical have signed a letter of intent (LOI) to discuss a partnership agreement to explore  Companies to work together with the aim of optimizing advanced technologies for use in prefillable syringes FRANKLIN LAKES a R&D-oriented chemical manufacturer based in Tokyo today announced that they have entered into an agreement to investigate further development of OXYCAPT™ - an innovation from MGC that integrates the best of plastic and glass for plastic syringes BD and the BD Logo are trademarks of Becton All other trademarks are the property of their respective owners Asia Pacific Silicone Rubber Market Analysis: Industry Market Size Copyright © ChemAnalyst - 2020 | Terms & Conditions | Privacy Policy has announced the commercial release of the BD Neopak XtraFlow Glass Prefillable Syringe and the latest capacity expansion of the BD Neopak Glass Prefillable Syringe platform to serve the growing market for biologic therapies The BD Neopak Glass Prefillable Syringe platform is designed to address key development needs for biologic drugs and customers have received approval to utilise this platform for more than 24 indications BD has expanded usability of this platform with the commercial release of the BD Neopak XtraFlow Glass Prefillable Syringe This solution features an 8-millimeter needle length and thinner wall cannula to optimize subcutaneous delivery of higher viscosity drug profiles by reducing the injection force and time required for a fixed solution viscosity enhancing flow and usability beyond today's limits versus a standard half-inch needle BD's manufacturing site in Le Pont-de-Claix, France has successfully integrated a high-volume manufacturing line for the BD Neopak Glass Prefillable Syringe platform increasing the production capacity of a single line by sevenfold MM Activ Singapore Pte Ltd 1 North Bridge Road,#08-08 High Street Centre communications@biospectrumasia.com +65 90150305 Copyright 2025 MM Activ Singapore Pte Ltd BD EffivaxTM Glass Prefillable Syringe Features Enhanced Technology that Builds on Company's Decades of Expertise in the Prefillable Syringe Market and Supports Customers' Manufacturing Needs FRANKLIN LAKES, N.J., Sept. 13, 2022 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX) The new BD EffivaxTM Glass Prefillable Syringe has been designed in collaboration with leading pharmaceutical companies to meet the complex and evolving needs of vaccine manufacturing "As biopharmaceutical companies continue to rapidly grow their vaccine pipelines demand for PFS is accelerating across the globe – given their proven ability to facilitate faster administration support dose sparing and reduce vaccine waste." said Eric Borin Worldwide President of BD Pharmaceutical Systems "The launch of BD EffivaxTM Glass Prefillable Syringe strategically supports this growth and will create needed efficiencies in end-to-end production." Approximately 70 percent of the top 100 biopharmaceutical companies rely on BD for supply of PFS.2  BD EffivaxTM Glass Prefillable Syringe will further help customers meet the stringent demands of today's vaccine manufacturing through design enhancements focused on fill/finish and container reliability BD EffivaxTM is designed to reduce the risk of line stoppage3 and improve the total cost of ownership,4 manufacturing capacity and supply availability including mRNA and those used for COVID-19 the company remains committed to maintaining robust capacity for PFS to help reduce the time and labor required for vaccine preparation with traditional vial formats About PFSPrefillable syringes (PFS) are an important option in the packaging and delivery of injectable drug products PFS help enable the administration of a drug in two ways a PFS is a drug delivery system designed to administer the appropriate amount of the drug to the patient both safely and reliably PFS packaging helps assure that there are no adverse effects on the quality purity or potency of the drug over its full shelf life Public Relations           201.847.5743          [email protected] [email protected]  Customer Quality Specification BD Hypak(tm) for Vaccine SC000110 BD Medical – Pharmaceutical Systems Le Pont de Claix 2 IQVIA-based analysis and BD internal Systems (SAP) today announced results for its fiscal 2025 second.. today announced that it will present at the Bank of.. December 2, 2022 By BD (NYSE:BDX) announced recently that it inaugurated a new $38.6 million manufacturing facility in Tijuana Government officials from Mexico and the state of Baja California joined in the opening of the medication management plant BD plans for the facility to produce devices and technologies that improve medication safety within healthcare settings The company expects to add 500 new jobs there over the next two years BD plans to create 75 jobs responsible for manufacturing automated dispensing cabinets that dispense medication to patients the company intends to export these devices to North America “Our new facility in Tijuana is BD’s 12th manufacturing plant in Mexico and is a testament to our commitment to Mexico and the strong relationship we’ve built in communities across the country over the past 65 years,” said Julio Duclos “The 17,000 BD employees in Mexico are focused on producing high-quality medical devices that are used by health care providers and patients around the world We look forward to continuing to grow in Mexico.” BD plans to build upon its six existing sites in Columbus announced a strategic collaboration with Ypsomed to advance self-injection solutions for high-viscosity biologic drugs Ypsomed and BD have pre-assessed and streamlined integration of the BD Neopak™ XtraFlow™ Glass Prefillable Syringe with Ypsomed’s YpsoMate® 2.25 autoinjector platform addressing current limitations by enabling the delivery of higher viscosity (>15cP) biologic drugs in an autoinjector format The BD Neopak™ XtraFlow™ Glass Prefillable Syringe is BD’s latest portfolio addition and thinner wall cannula to optimize subcutaneous delivery of higher viscosity drug profiles enhancing flow and usability beyond today’s limits versus a standard half-inch needle1,2* This solution is a part of the BD Neopak™ Glass Prefillable Syringe Platform which is designed to address key development needs for biologic drugs Ypsomed is expanding its YpsoMate® 2.25 two-step autoinjector platform to accommodate the new syringe format This includes adapting parts of the autoinjector for the shorter needle and performing extensive technical testing to ensure reliability The YpsoMate autoinjector device is handled in two steps: simply remove the cap and push on skin designed so that people with impaired grip or vision can administer their medication easily and safely Supporting our pharmaceutical partners to de-risk and accelerate combination product development “We are excited to welcome the first pharmaceutical customers to experience the benefits of the BD Neopak™ XtraFlow™ Glass Prefillable Syringe with the YpsoMate® 2.25 autoinjector,” said Ulrike Bauer Chief Business Officer of Ypsomed Delivery Systems “This collaboration underscores our commitment to enhancing patient care through innovative drug delivery solutions.” “Cross-supplier collaborations are vital in today’s pharmaceutical ecosystem,” said Patrick Jeukenne worldwide president of BD Pharmaceutical Systems “These partnerships can help drive innovation and ensure that systems work by design and over lifecycles allowing our pharmaceutical partners to get life-saving therapies to patients faster.”      BD and Ypsomed are key leaders in drug delivery enabling the administration of chronic condition therapeutics such as GLP-1s Combining BD’s robust syringe platform technology with Ypsomed’s leading autoinjector platform this collaboration leverages shared expertise to deliver reliable device systems “User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with staked 8 mm ultra-thin wall needle” https://doi.org/10.1080/17425247.2020.1796630 YpsoMate is a registered trademark of Ypsomed AG All Blog Posts › Tuesday World Subscribers only Israel prepares large-scale Gaza offensive to achieve lasting occupation World Subscribers only Romania enters government crisis amid election World Subscribers only In Zurich the leaf 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Layoffs are rising across sectors including automotive Politicians and trade unions are discussing how to stem further job losses Employees of the Vencorex chemical plant during a demonstration after the company went bankrupt in September JEFF PACHOUD / AFP Should we be working on developing a European industrial strategy Or should we instead hold companies that have received public funding accountable as suggested by trade union leaders Sophie Binet (CGT) and Marylise Léon (CFDT) should the government block the approval of certain redundancy plans as advocated by left-wing MP François Ruffin which is preparing to cut 2,389 jobs; and the receivership of chemical manufacturer Vencorex political leaders and trade unionists are wondering how to stop further losses on the social front In the three years after the Covid-19 pandemic companies – supported by state-guaranteed loans various aid programs during lockdowns and a relatively stable economy – hired extensively and laid off few employees the horizon is darkening and difficulties are piling up "There will probably be announcements of site closures in the coming weeks and months," Ferracci said on France Inter radio on Saturday referring to the possible destruction of "thousands of jobs." "We're at the start of a violent industrial bloodletting," said Binet of the CGT in the weekly La Tribune Dimanche the following day questioning companies' desire to "always increase margins" and "distribute ever more profit to shareholders." 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Save A young Denise Maso stands on the balcony of an apartment in Le Pont-de-Claix (Courtesy of Marion Renault)On her first night home from the hospital “Qu’est-ce que j’ai fait?”: “What did I do?” is 82 and in the late stages of Alzheimer’s disease which means she can no longer form new memories Late last summer—it’s impossible to say when Pain became the fall’s only remnant evidence to understand why she’d stopped eating or getting out of bed In anticipation of her second discharge from the hospital When I arrived at the apartment where she lived alone I was entirely unprepared for how intensely the Alzheimer’s could amplify her suffering My grandmother’s throat rattled with every breath she kicked her legs and flailed her arms when I tried to get her out of bed to eat She developed a cough so intense that it sounded and sometimes did turn into vomiting as her body tried to convulse the pain away resulting in a panic that made her even more vulnerable to its punishment “To have pain is to have certainty,” the essayist Elaine Scarry wrote in her 1985 book “To hear about pain is to have doubt.” Helping someone cope with pain requires glimpsing the invisible interior of another person’s body—and then accepting that imagined suffering as real and true When a patient’s cognitive condition prevents reliable self-assessment our ability to see a person’s pain and treat what we see is even further limited the riddle of their suffering becomes nearly unsolvable can undermine the entire process of conveying pain A person with Alzheimer’s might express discomfort by wandering but the same behaviors might express loneliness or sadness—or they might be symptoms of the disease itself Asked to choose which emotional expression on a chart matches their current state point to the face they think they should feel told me about a patient who complained of frequent headaches Only later did she realize that “headache” was the woman’s metaphor for not being able to remember “It just adds to the complexity of taking care of people with Alzheimer’s disease,” Brangman said “That person may not be able to communicate what’s wrong with them.” Instead of figuring out how to ease the suffering caregivers are stuck simply trying to understand its source “It’s a population that’s just silently suffering,” Todd Monroe a registered nurse and neuroscientist at Ohio State University In addition to the five senses, nineteenth-century German academics believed in Gemeingefühl: a slate of perceivable bodily states “in the most diffuse and general sense”—fluctuating temperatures “and perhaps throw light on what parts of the brain were involved in producing such feelings.” Read: Beating Alzheimer’s with brain waves Melzack’s invention, the McGill Pain Questionnaire asked patients to describe their pain using words that fell into three categories: the sensory The sensory category identifies pain’s physicality through qualities such as temperature or sting—and each of these sensations can be unlike any of the others.) affective category capture pain’s emotional impact—whether it exhausts or sickens and most narrow evaluative category assesses the overall episode: Was it annoying language can provide “an external image of interior events,” as the essayist Scarry put it Questionnaires like the MPQ also elevated pain from a handful of physical symptoms to an experience nested in emotion and there’s the suffering of pain,” says Nancy Berlinger Alzheimer’s irreversibly robs a person of the cognition required to make this conception of pain medically useful a person loses the ability to create new memories or convey the world around and inside them Over the past quarter century, about 30 different tools or methods have been developed to specifically assess pain in people with dementia. Unfortunately, general practitioners who take care of these patients are often not even aware of their existence. (A 2018 survey of 157 GPs in Ireland found while 98 percent of respondents agreed that dementia makes pain difficult to assess only 10 percent were aware of any dementia-specific pain-assessment tools.) And evidence for their effectiveness often comes from studies with small sample sizes and other sources of biases Among the dozens of options, there is no general agreement on which instrument or technique should be recommended for patients with dementia “There’s not one single tool that’s determined to be the best,” Monroe is the uncertainty about how Alzheimer’s disease affects a person’s various pain-perception networks It’s clear that the disease impacts their ability to assign meaning to pain That has led to some cruel assumptions about people with Alzheimer’s some caretakers—professional and otherwise—decided it wasn’t worth the hassle of treatment if the patient couldn’t perceive physical sensations or would soon forget any unpleasant episodes I would hear that Alzheimer’s patients don’t feel pain or they don’t feel it as much,” Monroe says The body processes pain through several interconnected neural networks that help a person feel, describe, understand, and respond to pain. Preliminary research in neuroscience suggests that the major brain regions involved in pain perception and processing still function there’s no absence of brain activity in the areas related to pain “If somebody thinks dementia has just messed the brain up so much they don’t feel pain five years of active recruitment led by a dedicated recruitment specialist and a full-time research assistant resulted in the successful testing of fewer than two participants The result is that most of the existing clinical research has been conducted on participants who are younger and more mobile than the overall dementia population (women and Black and Latino people are the most likely to develop dementia) Any treatments based on these studies might not work as well in patients not represented in the trials—which is to say “I don’t think we have enough answers,” Brangman told me Evelyne and Jocelyne.Without reliable research to guide them caregivers are left to rely on their patients’ visible symptoms of untreated discomfort—exclamations like “Ow” or “Ouch,” and movements like massaging But even for people closest to the patient Brangman has seen patients become agitated not because of pain or anger but because of low blood sugar or high blood pressure They might stop sleeping because they’re uncomfortable or cold or stop eating because they’re lonely told me her mother often complained of chest pain and trouble breathing in the last five years of her life Doctors told McDaniel it was only allergies though allergy medicine did nothing to alleviate any discomfort Some suggested that her mother wasn’t feeling the pain she was describing One doctor wrote it off as a cry for attention McDaniel’s mother had been suffering from breast cancer She died less than six months after the cancer diagnosis “We didn’t put two and two together until it was much too late,” McDaniel said “I still feel guilty to this day for not listening to her instead of the doctors.” Read: Is the leading theory about Alzheimer’s wrong? “You have to look for other signals that they’re uncomfortable And it’s not one set thing,” Brangman said “It takes a lot of intuitive work and careful examination.” Given the tightening squeeze on geriatric care in the U.S. it’s not always possible for practitioners to form these kinds of close sustained relationships with their patients and even fewer of them are trained to deal with the complexities of dementia As the number of people with Alzheimer’s more than doubles by 2050 In the absence of a robust professional workforce, family members, friends, or other unpaid caregivers provide a large majority—about 83 percent—of elderly care. Among them, more than 16 million provide an estimated $244 billion worth of care for those with Alzheimer’s or other forms of dementia but they must nevertheless try to translate subtle facial expressions or unusual habits to doctors and nurses when they suspect that a person with dementia is suffering from untreated pain Many of the experts I spoke with had relatives or friends who had suffered from these diseases Monroe’s grandmother battled breast cancer and Alzheimer’s at the end of her life they felt a powerlessness they’ve tried to dismantle through research or medical care Alison Anderson, a nurse practitioner and dementia researcher at Vanderbilt University, watched her mother struggle through early dementia as she began studying the disease. In 2017, Anderson examined existing research and found study after study suggesting that the basics of care—touch and the presence of another human being—can help relieve pain in dementia patients my grandmother now resides in the Alzheimer’s wing of a nursing home I found that our moments of communion kept her physical agony at bay We rooted through boxes of old photographs together and I distracted her with stories about how I had filled my suitcase with sesame bagels for her all I could do for her was lie down in bed beside her as she whimpered During the confinement period, you can access PSG TV Premium for free and enjoy all this season's match videos. Learn more You are using an outdated browser. Please upgrade your browser to improve your experience Passionate about football despite being a late starter in the game the native of Grenoble hit the ground running after getting her start with second-division side Claix at 16 She quickly moved up to the first division with Arras before two successful seasons with Guingamp saw her claim the captain's armband aged just 20 This lightning rise saw her inducted into France’s youth teams with whom become a European U19 champion in 2013 (scoring the winner in the final) and then a bronze medallist at the U20 World Cup in 2014 (by scoring the winner in the third-place play-off) where she honed her skills for two seasons and joined the French senior team in the process scored two goals and won the Coupe de France in 2018 the French international was loaned to Utah Royals FC (USA) and in January 2021 she moved to Atlético de Madrid before returning to the capital club in the summer of 2021 The Guardian’s picture editors select photographs from around the world The Guardian’s picture editors select photographs from around the world Photograph: Anatolii Stepanov/AFP/Getty Images Photograph: Monirul Bhuiyan/AFP/Getty Images Photograph: Jean-Philippe Ksiazek/AFP/Getty Images Photograph: Sanaullah Seiam/AFP/Getty Images You can read this article in 12 minutesAgnieszka Kulikowska - Wielgus French traffic bans apply to trucks and vehicle combinations with a DMC above 7.5 tonnes with the exception of special vehicles and agricultural vehicles This guide explains when the bans are in force in 2021 The truck bans start at 10pm on Saturdays and the evening before public holidays and last until 10pm on a Sunday or a public holiday The calendar of holidays in France for 2021 is as follows: the following additional restrictions will apply in France: – Prohibitions in winter : from 7 am to 6 pm on the ‘Auvergne-Rhône-Alpes’ roads listed below 20th as well as February 7th and March 6th 2021 – A40 from Pont d’Ain (intersection A40 / A42) to Passy-le-Fayet (intersection A40 / RD1205) – RD1084 from Pont d’Ain (intersection RD1084 / RD1075) to Bellegarde – A43 from the A46 south / A43 junction to the A43 / A432 junction towards Lyon-Chambery – A43 from the intersection A43 / A432 to Frejus Tunnel – A430 from Pont Royal (intersection A43 / A430) to Gilly-sur-Isere (intersection A430 / RN90) – RD1090 from Pont-Royal to Gilly-sur-Isere (intersection A430 / RN90) – RN90 from Gilly-sur-Isere (intersection A430 / RN90) to Bourg-Saint-Maurice – RD306 (Rhône) and RD1006 (Isère and Savoie) from Saint-Bonnet-de-Mure to Freney – A48 from Coiranne (intersection A48 / A43) to Saint Egrève (intersection A48 / A480) – A480 from Saint Egrève (intersection A48 / A480) to Pont-de-Claix (intersection A480 / RN85) – RN85 from Pont-de-Claix (intersection A480 / RN85) to Vizille (intersection RN85 / RD1091) – RD1091 from Vizille (intersection RN85 / RD1091) to Briançon – A41 north from Saint Julien-en-Genevois (junction A40 / A41 north) to Cruseilles (junction A410 / A41 north) – RD1201 from Saint Julien-en-Genevois to Annecy – A410 from Scientrier (intersection A410 / A40) to Cruseilles (intersection A410 / A41 north) -A41 north of Cruseilles (junction A410 / A41 north) to the junction with A43 Chambery – A41 south between Grenoble and A43 (Francin) on Montmelian northbound – RD1090 between Montmelian (73) and Pontcharra (38) – Summer bans: from 7 to 19 for the whole of the French road network on Saturdays: 24 and 31 July and 7 14 and 21 August 2021 r. In the Saturday traffic will be allowed from hours additional traffic bans will apply as every year They apply to specific roads in a specific direction and are valid on the following dates: – on the eve of a public holiday from 4pm to midnight – Saturdays from 10am to 6pm and from 10pm to midnight – Sundays and public holidays around the clock – Saturdays and the eve of public holidays from 10pm to midnight – Mondays and the day after a public holiday from 6pm to 10pm The bans in Île-de-France include the following motorway sections: A6b from the Paris beltway to the intersection with the A6 and A10 motorways (commune of Wissous) – A106 from the intersection with A6b to Orly airport – A6 from the intersection with A6a and A6b to the intersection with RN 104-Est / East (commune of Lisses) – A10 from the intersection with A6a and A6b to RN20 (commune of Champlan) – A12 from the junction with the A13 (Rocquencourt triangle) to the RN10 (Montigny-le-Bretonneux commune) – A13 from the Paris ring road to the Poissy-Orgeval junction (Orgeval commune) truck traffic is permanently banned on some roads in France – national road N59 between Lunéville and Sélestat – a ban applies on all vehicles in transit with a GVW exceeding 3.5 tonnes – national road N66 – prohibitions in place for vehicles over 3.5 tons between Remiremont and Cernay; ban for vehicles over 19 tonnes between 6am-10pm with a loading or unloading point in Lorraine (Lorraine) or Alsace (Alsace) national road N227 (3 – 4 km) – prohibition for vehicles in transit over 3.5 tonnes leaving the A1 motorway and heading north – A557 motorway – prohibitions for vehicles over 3.5 tons – A55 motorway (4 km) – prohibitions for vehicles over 3.5 tons in Marseille between the Vieux Port intersection and the Cap Pinède intersection – connection of the A50 (Toulon est / Toulon east) and A57 (Toulon est / Toulon west) motorways – Toulon tunnel – no heavy goods vehicles over 19 tonnes going to Marseille – A8 motorway – a 24-hour ban on the carriage of ethylene oxide by road on the section between the toll station in Antibes and Italy. For this type of transport the sea route Lavera – Tavazzano is recommended – national road N7 – traffic ban for vehicles over 6 tons on the transit route through the Orange agglomeration between the intersection with the RD976 and the intersection with the RD950; a ban on vehicles with a GVW of over 16 tons on the transit route through the Mondragon agglomeration – national road N85 – no vehicles over 26 tons (not equipped with speed limiters) on the border of the departments of Isère and Hautes Alpes and the city of Gap – national road N580 – traffic ban for vehicles over 25 tons in Avignon – national road N94 – vehicles over 26 tons (not equipped with speed limiters) between the southern Embruns roundabout and the border with Italy are prohibited – A7 and A6 motorways (25 km) between Ternay and Anse – vehicles with a DMC above 7.5 t are prohibited – national road N205 (Mont-Blanc Tunnel) – no vehicles carrying hazardous materials vehicles with a height exceeding 4.7 m and cars meeting Euro 0 emission standards – A43 motorway Fréjus tunnel – no vehicles carrying class 1 hazardous materials vehicles with a height exceeding 4.3 m and cars meeting Euro 0 emission standards – A47 motorway – traffic ban on the section connecting A47 (westbound) and A7 towards Lyon city center (Ternay intersection) – national road N7 – traffic ban for vehicles with a GVW over 6 tonnes – national road N7 in Tain l’Hermitage – no vehicles over 3.5 tons southbound between Vienne and the Roussillon toll station – national road N85 Laffrey – traffic ban for vehicles with a GVW above 7.5 t – Lyon North Bypass – vehicles with a height exceeding 3.5 m and trucks over 19 tons and vehicles carrying hazardous materials are prohibited – Fourvière Tunnel – vehicles with a height exceeding 4.3 m and for trucks transporting hazardous materials are prohibited Photo credit: François GOGLINS / Wikimedia Commons Pölös Zsófia Journalist Trans.info | 6.05.2025 Fragrance on the Fly: Why Pocket Perfumes Are Perfect for Airplane TravelSponsored Article 6.05.2025 You can read this article in 5 minutesAgnieszka Kulikowska - Wielgus The French authorities have published dates for additional winter and summer truck traffic restrictions Photo credits @ Wikimedia Commons (illustrative purposes only) the French Ministry of the Interior issued a decree supplementing the general system of traffic restrictions for heavy goods vehicles with a gross vehicle weight (GVW) of over 7.5 tonnes The decree introduces additional winter traffic bans on the road network in the “Auvergne-Rhône-Alpes” region These restrictions will be in effect on Saturdays Bellegarde and Saint-Julien-en-Genevois – Annecy – Albertville truck traffic is restricted across the entire road network of mainland France on Saturdays