ORLANDO, Fla. (Feb. 25, 2025) – Orlando City SC has acquired the SuperDraft Priority to forward Dyson Clapier from Sporting Kansas City, in exchange for the Lions’ natural second round pick in the 2026 MLS SuperDraft, it was announced today. Following the trade, Orlando City B has signed the winger to an MLS NEXT Pro contract through 2025, with a Club option in 2026. "Dyson is a winger that has skills both on and off the ball that we truly feel will fit well within our Club and we’re excited to bring him to Orlando,” said Orlando City VP of Soccer Operations and Technical Director Ricardo Moreira. “He’s a domestic player that can add further depth for us across our whole ecosystem and we think this will be a great step for both the Club and the player.” Clapier was selected out of the University of Akron 51st overall by Sporting KC in the 2024 MLS SuperDraft, returning to college for a fifth season. The Layton, Utah native scored 19 goals and provided 20 assists across five collegiate seasons at Akron from 2020-2024. TRANSACTION: Orlando City SC acquires the SuperDraft Priority to forward Dyson Clapier from Sporting Kansas City in exchange for the Lions natural second round pick in the 2026 MLS SuperDraft. Following the trade, the Lions have signed Clapier to an MLS NEXT Pro contract with Orlando City B through 2025, with a Club option in 2026. Sporting Kansas City announced today that the club has acquired a natural second-round pick in MLS SuperDraft 2026 from Orlando City SC in exchange for the SuperDraft Priority to forward Dyson Clapier. Sporting selected Clapier with the 51st overall pick in MLS SuperDraft 2024, securing his SuperDraft Priority through the end of 2025. Clapier returned to the University of Akron for a fifth college season in the fall of 2024, then joined Sporting KC for the first leg of the club’s 2025 preseason in Miami, Florida. Clapier, 22, had 19 goals and 20 assists across five collegiate seasons at Akron from 2020-2024. Sporting will visit Inter Miami CF tonight in the decisive second leg of Round One in the Concacaf Champions Cup, looking to overturn a 1-0 aggregate deficit and advance to the Round of 16. Kickoff is set for 7 p.m. CT at Chase Stadium in Fort Lauderdale, Florida, with live coverage on FS2, TUDN and ViX. Transaction: Sporting Kansas City (MLS) acquires a natural second-round pick in MLS SuperDraft 2026 from Orlando City SC (MLS) in exchange for the SuperDraft Priority to forward Dyson Clapier. Sporting Kansas City vs LA Galaxy Match Thread Match Preview: Sporting KC Hosts Struggling Champion LA Galaxy Amidst Early Season Questions Sporting Kansas City at FC Cincinnati Match Thread Current drops second straight in 1-0 loss at Seattle KC Current suffer defeat in North Carolina Kansas City Current at North Carolina Courage Match Thread The Blue Turf: Comets have two big games ahead The Blue Turf: Three straight wins but the Sockers are next The Blue Turf: Comets take huge win over Chihuahua Des Moines Menance Defeat Sporting KC II via Two Penalty Kicks Feilhaber Brings a Team of MLS Retirees to Des Moines to face Sporting KC II Benny Feilhaber and Des Moines Menace to Play Against Sporting KC II Sporting KC II to Play in 2025 US Open Cup Here’s the rest of this week’s update. Note: Players under contract to Sporting Kansas City at this time are not included on this list, the exception being players loaned outside of Kansas City. Across State Lines: Former Players Find New Clubs Across State Lines: Tzionis Moves to Romania Across State Lines: Scott Scores First Professional Goal Across State Lines: Russell in Talks to Join Salt Lake Across State Lines: Duke Signs with Louisville Be the first to know when news breaks, sign up to get all of our posts sent directly to your inbox. Copyright © 2024 Kansas City Soccer Journal / The Blue Testament The player immediately moves to the Orlando City B roster for this season Forward Dyson Clapier comes to Orlando City SC from Sporting Kansas City With hot prospect Yutaro Tsukada out for the season – first team player Wilder Cartagena is also out – the Lions front office is watching the B squad closely in case help is needed during the heat of the season Those players need to be kept sharp in competitive conditions Vice President of Soccer Operations and Technical Director Ricardo Moreira said the organization is looking to add Clapier to the Orlando City ecosystem for depth The club acquired him through his SuperDraft Priority Clapier was selected by Kansas City in the 2024 SuperDraft out of the University of Akron but returned to college for a fifth season He scored 19 goals plus 20 assists throughout his five seasons As he didn’t sign with the league, Clapier was placed on Sporting Kansas City’s SuperDraft Priority List so Orlando City traded the club a natural second-round pick in the 2026 SuperDraft Sporting would have lost priority rights to sign the player on Dec Scouts don’t have to travel far to assess strong talent for the first team as they develop and compete with Orlando City B Midfielders Gustavo Caraballo and Colin Guske are on short-term contracts with the first team Awaiting Clapier on the pitch are highly regarded midfielder Jhon Solis and defender Zakaria Taifi As Orlando City SC picks up the speed and passing accuracy to start defeating their opponents © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER Vice President of Soccer Operations and Technical Director Ricardo Moreira said the organization is looking to add Clapier to the Orlando City ecosystem for depth As he didn’t sign with the league, Clapier was placed on Sporting Kansas City’s SuperDraft Priority List Scouts don’t have to travel far to assess strong talent for the first team as they develop and compete with Orlando City B. Clapier will be in a strong, competitive environment. Midfielders Gustavo Caraballo and Colin Guske are on short-term contracts with the first team. Awaiting Clapier on the pitch are highly regarded midfielder Jhon Solis and defender Zakaria Taifi. As Orlando City SC picks up the speed and passing accuracy to start defeating their opponents, it will be a season worth experiencing. •\tClub got the SuperDraft Priority, then the player•\tOrlando City B gains a striker prospect•\tForward will develop for organization depth This afternoon, Sporting KC announced their preseason schedule and roster for at least the start of the 2025 preseason The first phase that started on Sunday will continue through the 29th of January in Miami Kansas City will then head to Southern California to finish out preseason from February 2nd through the 12th before kicking off the 2025 season at Children’s Mercy Park on the 18th of February against Inter Miami in the CONCACAF Champions Cup Sporting currently have three games scheduled in each location with games against Florida International University and Charlotte FC in Miami and games against New York City FC and the Las Vegas Lights while in California Also included in the release was an updated roster for Sporting KC that includes numbers for the new players on the team None of Kansas City’s returning players have new numbers at this point but Sporting’s four new players all have their numbers: Finally, the announced roster also included ten players that were invited to join the team for preseason. One note pointed out by Daniel Sperry Leon Koehl has chosen to return to Maryland Sporting’s 2025 first round draft pick He played in 20 games for Indiana in the 2024 college season He can play both center back and right back Anthony Samways: Sporting’s second round draft pick in the 2025 draft out of Ohio State Dyson Clapier: Sporting’s second round pick in the 2024 SuperDraft Clapier elected to return to school for the 2024 season instead of turning pro and is now in camp with Sporting Jan Jurcec: The one trialist in camp with no previous ties to Sporting. The 24 year old Jurcec comes to Kansas City having last played with SCR Altach in the Austrian Bundesliga Jurcec played over 60 games scoring 2 goals and adding 3 assists playing on the right side as a winger But he has been without a club since the end of the last European season Jurcec played with NK Kustosija Zagreb in his home country of Croatia He also made a handful of appearances for Croatia’s U21 team Carson Klein: The former Sporting KC II player and son of Sporting Legend Chris Klein joins the first team as a trialist for preseason this year Klein made 11 appearances for Sporting KC II in the 2024 MLS Next Pro season 9 of them starts after joining SKCII halfway through the 2024 season Klein was one of seven players who were out of contract at the end of the 2024 MLS Next Pro season Cielo Tschantret: The lone Sporting KC II contracted player to join SKC for this phase of preseason Tschantret signed his first pro contract with Sporting KC II ahead of the 2024 MLS Next Pro season he’d played with the team in 2023 on an academy contract During that stretch he’s scored 3 goals and added an assist Tschantret earned a spot on the bench for the first team in the 2024 Leagues Cup game against the Chicago Fire Johann Ortiz: A Sporting KC academy player who spent time in 2024 with Sporting KC II on an academy contract Leo Christiano: Another Sporting KC academy player who played with SKCII on an academy contract Christiano played for Sporting in both the 2023 and 2024 MLS Next Pro seasons In those two seasons he’s made 17 appearances Jacob Molinaro: The third Sporting KC academy player on the list of players invited to camp like the other two academy players played with Sporting KC II last year on an academy contract Molinaro played 10 games for SKCII last year recording a 3-5-2 record for KC Sebastian Cruz: Former Sporting KC academy player Cruz is in camp as a trialist with the first team Cruz has spent the last two years under contract for SKCII 39 starts scoring 10 goals and adding 7 assists He’s also played with the first team having been called up in the 2023 season for KC’s US Open Cup run appearing in KC’s 3-0 win over Tulsa Athletic Cruz made the bench again for the first team in 2024 during the Leagues Cup being available for both the games against the Chicago Fire and Columbus Crew but didn’t appear in either game Given how the invitee list has worked in past years it’s likely that this list will change as the preseason continues Ten Important Quotes about the 2025 Sporting KC Season Rumor: Sporting KC Linked to Spanish Midfielder Juice Boxes and Post Game Stats: Week of Down Results sign up to get all of our posts sent directly to your inbox University of Akron men's soccer players Jason Shokalook Malik Henry and Dyson Clapier were selected in the 2023 MLS SuperDraft on Tuesday 32nd and 33rd Zips to be drafted in an MLS SuperDraft Akron's run of draft picks has been under three coaches: Ken Lolla Shokalook was selected with the sixth selection of the second round (35th overall) by Chicago Fire FC Henry was drafted with the 10th pick of the second round (39th overall) by CF Montreal and Clapier was tabbed with the 22nd pick of the second round (51st overall) by Sporting Kansas City Shokalook earned United Soccer Coaches All-America second-team honors in 2023 He started all 17 games in which he appeared for UA (9-2-7 Shokalook totaled 26 goals and 17 assists in 59 matches (41 starts) Henry helped the Zips lead the Big East with 10 shutouts and a 0.56 goals against average Henry had 12 assists in 50 matches (47 starts) Clapier totaled 14 goals and 12 assists in 57 matches (48 starts) 50 Akron players have gone on to play professionally either in Major League Soccer Michael Beaven can be reached at mbeaven@thebeaconjournal and is on Twitter at @MBeavenABJ Every product is independently selected by editors Things you buy through our links may earn Vox Media a commission Most of the apartments in 333 East 68th Street a red-brick Neo-Georgian building situated on St are fairly staid — tastefully renovated with austere finishes and hints of character from an odd chandelier or molded fireplace six-room apartment has been renovated by WQB Architecture to resemble a chateau in Provence two carved-marble wood-burning fireplaces; herringbone floors; a hand-painted mural of a French Baroque garden landscape depicting classical marble statues and lush but manicured greenery in the stairway leading to the library; an arch painted with sirens between the living room and second bedroom; and a robin’s-egg-blue coffered ceiling with intricate crown moldings and hand-painted gilded detailing Price: $4,995,000 (monthly maintenance: $7,432) Street view: A tree-lined one-way street of pre-war high-rise apartment buildings with a park and school Listed by: Paula Del Nunzio / Brown Harris Stevens The large dining room is clad in intricately carved wood paneling with a delicate floral-and-lattice-patterned ceiling Built-in bookcases and hand-painted murals of angels and foliage climb the 13-foot ceilings of the wood-paneled office and the loft with a built-in captain’s bed No surface of this apartment has been left unpainted including painted lace trim and Corinthian columns The unit occupies the entire 15th floor of the eastern side of the building allowing for a large landscaped terrace that wraps around the apartment on three sides with views of the East River and the Chrysler Building was designed to be “a regular Park Avenue type building” but at about half the price the 22-year editor of Vanity Fair and one of the founding trustees of the Museum of Modern Art (who was once described by Amy Fine Collins as “the most cultivated He lived in one of the penthouses for a time in the ’30s but based on the historical archive alone it’s difficult to be certain which The other penthouse apartment in the building is on the ninth floor — also a six-room triplex with private terraces including a stint as the president of the now defunct luxury Hôtel Plaza Athénée a five-star hotel on East 64th that features similarly intricate murals and crown moldings and he has been active in many of the city’s French American social clubs His love of French culture is more than apparent in his painstaking renovations Password must be at least 8 characters and contain: you’ll receive occasional updates and offers from New York It has become quite common to hear the names of University of Akron players when the MLS has its SuperDraft but here’s the rub — Henry and Clapier are coming back to Akron “It’s always an exciting day to see players get picked up and the interest others have in the program,” Zips coach Jared Embick said “The MLS is starting to take steps like other sports where you can be drafted and still go to school and the pro team retains your rights until you graduate.” That’s the clause Henry and Clapier used as both are on track to graduate in December The 5-foot-11 forward came into last season with high hopes as a first team All-Big East preseason selection and a MAC Hermann Trophy candidate 4 on TopDrawerSoccer.com’s preseason 100 list an injury limited Clapier to eight starts and 12 games in which he registered two goals and two assists “It was a great feeling to get drafted and be around my family to celebrate that,” Clapier said but we have some unfinished business in Akron it’s better to come back off that injured year and come back ready.” The Zips put together a 9-2-7 season in 2023 and lost just one regular-season game They spent a solid portion of the year ranked but their name wasn't called when the brackets came out for the NCAA Tournament it hurt not making the tournament,” Clapier said Henry echoed Clapier’s feeling after a season of just misses The 5-7 defender helped the Zips to 10 shutouts and a 0.56 goals against average in 14 games and 13 starts and logged four assists That earned him the 39th pick in the draft “I think coming back to Akron was the best decision I could make,” he said “I’ll be able to get my degree in the fall and I feel like the Zips have something to prove We’re going to give them no reason to leave us out.” When Henry does play for Montreal he’ll have a Cleveland Browns vs Pittsburgh Steelers situation on his hands so in a sense Henry is changing allegiances It’s really great to play in the MLS in the country I was born in.” Shokalook started 17 games and led the Zips in goals (14) shots on goal (41) and game-winners (3) and was seventh in the NCAA in goals he totaled 26 goals and 17 assists and started 41 of the 59 games in which he played That earned him the 35th pick by Chicago and a future in the MLS “He’s got a professional frame at 6-1,” Embick said good speed and has a lot of potential to offer get on the end of things and stretch the game Contact Brad Bournival at bbournival@gannett.com and follow him on Twitter at @bbournival Sporting Kansas City selected three college standouts on Tuesday in MLS SuperDraft 2024 presented by adidas picking goalkeeper Ryan Schewe from Georgetown University with the 22nd overall pick in the first round forward Dyson Clapier from the University of Akron with the 51st overall pick in the second round and defender Jonathan Robinson from Western Michigan University with the 80th overall pick in the third round With the 22nd pick of the 2024 MLS #SuperDraft, #SportingKC selects goalkeeper Ryan Schewe from @GeorgetownHoyas. pic.twitter.com/FdhOlX14Rf Schewe attended the adidas MLS College Showcase earlier this month -- recording the highest vertical -- and was selected in the first round after two outstanding seasons in goal at Georgetown University while also featuring for Apotheos FC (NPSL) in 2022 and the Westchester Flames (USL League Two) in 2023 The 6'4" goalkeeper appeared in 29 matches during the 2022 and 2023 collegiate campaigns recording 86 saves and 12 shutouts with a 20-4-4 record and a 0.79 goals against average Schewe was a Second Team All-BIG EAST selection as a junior after earning the starting spot and leading the conference in save percentage and shutouts the 21-year-old senior guided the Hoyas to the BIG EAST regular season championship while leading the conference with the lowest goals against average and the most clean sheets He earned BIG EAST Goalkeeper of the Year and First Team All-BIG EAST honors as well as United Soccer Coaches Second Team All-East Region recognition With the 51st pick in the second round of the 2024 MLS #SuperDraft, #SportingKC selects Dyson Clapier from @ZipsMSoc. pic.twitter.com/KeAFwNTqCK Clapier starred at the University of Akron for the past four years tallying 14 goals and 12 assists in 57 appearances before being selected in the second round of the MLS SuperDraft Clapier was a Second Team All-MAC selection in 2021 and led the Zips in assists in 2022 earning Third Team All-America and First-Team All-North Region honors from United Soccer Coaches along with First Team All-MAC recognition in addition to an invite to the adidas MLS College Showcase the 21-year-old forward played two seasons in the USL Championship for Portland Timbers 2 in 2019 and 2020 - debuting at the age of 17 - before moving to USL League Two side Park City Red Wolves in 2021 Clapier won the College Spring League Golden Boot with five goals in four matches and most recently Clapier joined NPSL club Akron City FC in 2023 With the 80th pick in the third round of the 2024 MLS #SuperDraft, #SportingKC selects defender Jonathon Robinson from @WMUMensSoccer. pic.twitter.com/ciyy7k3RJ5 Coming off a stellar season in which he tied the school record and finished second in the NCAA with 13 assists Robinson was selected in the third round of the MLS SuperDraft The 22-year-old defender captained Western Michigan University to the regular season and Missouri Valley Conference tournament titles while earning First Team All-MVC and First Team All-West Region honors in 2023 while also debuting for the Flint City Bucks in USL League Two Sporting KC Vice President of Player Personnel Brian Bliss On second round selection Dyson Clapier… On third round selection Johnson Robinson… We always try to target a few positions. We didn’t have a ton of openings in our roster in terms of numbers wise. Obviously, we he had a little bit of a hole in the middle of the midfield and at the backup goalkeeper position. The goalkeeper was a little bit more targeted, and the others were more of a best available. I am just so thankful for this opportunity. I am celebrating with my family right now and I am extremely excited to see all that awaits. I am extremely grateful. I would like to thank everyone who has gotten me to this point and I am ready to work. It was a crazy experience waiting, one of the worst waits of my life. Around the holidays, there's no better present than being drafted. I'm happy to be selected by KC and I can't wait to meet the team. BRADENTON, Fla. (April 15, 2025) – Orlando City B (3-2-1, 11 points) battled Inter Miami CF II (2-3-1, 7 points) at IMG Academy Stadium on Tuesday night. The Lions suffered their second loss of the season, despite a late goal by Shak Mohammed and push for the equalizer. Despite the loss, Orlando City B received contributions from all over the pitch in the match with goals from defender Tahir Reid-Brown and midfielder Shak Mohammed, as well as assists from OCB midfielder Riyon Tori and forward Dyson Clapier. At the end of second-half stoppage time, Orlando City midfielder Shak Mohammed was able to get OCB back within a goal after converting his penalty kick, but time ran out before the Lions could find their second equalizer of the night. Mohammed now sits tied for second in MLS NEXT Pro at four goals on the season. The Lions will return home to host New York Red Bulls II on Sunday, April 27. The game will stream live on MLSNEXTPro.com, with kick-off set for 7 p.m. ET at Osceola County Stadium in Kissimmee, Florida. The University of Akron men's soccer team opened the 2023 season in impressive fashion Thursday night at FirstEnergy Stadium The Zips were in a familiar position all evening as they attacked and pursued goals against overmatched Niagara Will Jackson, Dyson Clapier, Johnny Fitzgerald, Gyuwon Chong, Josef Paulus and Stefan Dobrijevic each scored a goal to lead Akron to a 6-0 win before a crowd of 1,174 "We need to build off of this," Jackson said We came in with a defensive mindset and I think we achieved our goal with a shutout." The Zips dominated play and held an edge in shots (27-3) shots on goal (13-2) and corner kicks (6-2) "The boys executed the plan perfectly," UA associate head coach Ger Coppinger said Coppinger led the Zips as head coach Jared Embick assistant Michael Nanchoff and junior forward Jason Shokalook each served a one-game suspension that carried over from last season's NCAA Tournament loss to Pittsburgh Hudson graduate Will Jackson propels Akron to men's soccer winJackson opened the scoring in the fourth minute with his goal Paulus and Fitzgerald assisted on the strike after Clapier started the sequence with a shot on goal "I say thanks to my teammates," said Jackson "It was a bouncing ball in the box and I think we won two or three 50-50s popped out to us and it was an easy finish from there a junior who was named to the 2023 Missouri Athletic Club's Hermann Trophy Watch List before the match netted his goal in the 30th minute with junior Jonas Buechte and senior Joel Sangwa each getting an assist "The second goal really opened everything up for us," Coppinger said "We were able to play our game — get after them found the net in the 43rd minute off a pass from junior Wan Kuzri Wan Kamal "This was mission accomplished and onto the next one," Fitzgerald said "I am always happy to contribute to the team when I can on the scoresheet but Firestone alum Stefan Dobrijevic score goals in Akron men's soccer winSeniors Sam Tojaga and Alejandro Varela assisted on the goal by Chong a senior and 2019 Highland High School graduate netted his goal in the 58th minute off a free kick from 22 yards out a sophomore and 2022 Firestone High School graduate converted a penalty kick in the 72nd minute sophomore Rui Reis and 2023 Wadsworth High School graduate Jackson Herbert were also active in Akron's attack that led to Zips freshman goalkeeper Seth Wilson facing and saving only two shots "What was great was the amount of guys we got on the field and the level never dropped," Coppinger said University of Akron men's soccer player Dyson Clapier made the most of his one shot on goal Monday night at FirstEnergy Stadium Malik Henry sent a pass to Clapier in the 61st minute and the Layton, Utah, native finished his lone scoring chance to propel Akron to a 1-0 win over the University of Vermont in a matchup of two teams ranked in the top 25 "I saw Malik flip the ball back post and as soon as it went over everyone's head and no way I am missing that,'" said Clapier who is one of 37 players on 2023 Missouri Athletic Club's Hermann Trophy Watch List I kicked the corner flag and celebrated with my team." Vermont (1-1), ranked No. 7 in the country in the TopDrawerSoccer.com poll, generated five shots on goal, but Akron keeper Seth Wilson denied each one were a national quarterfinalist in last year's NCAA Tournament "This is a very good win," Akron coach Jared Embick said "Vermont has got the belief and experience back from the Elite Eight and you could feel that I think in the start we were probably a little too tense and then we got a little better as the half went on "I thought in the second half we were excellent we really took control and played a lot of the soccer we are capable of playing Seth was outstanding in goal and the back four was awesome." "We showed a lot of resilience that we can grind out a tough game against a big, physical team," Henry said. "We showed that we can play our brand of soccer against basically anybody." Said Clapier: "This shows that we can compete with anyone in the nation. This is a signature win against a top 10 opponent. Vermont is a heck of a team." Michael Beaven can be reached at mbeaven@thebeaconjournal and is on Twitter at @MBeavenABJ. 4vs0VCU Akron started the scoring when senior Jonas Buechte (Rantigen, Germany) notched his first goal of the season in the 26th minute (25:04) knocking in the deflection off of a free kick from redshirt senior Victor Gaulmin (Guipavas The Zips assumed a 3-0 edge on Clapier's 56th-minute (55:12) goal, his second of the season. Redshirt senior Emil Jaaskelainen (Bolton, England) and senior Malik Henry (Hamilton the 16th-seeded University of Akron men’s soccer team is playing Pitt for the second time this season but unlike the 72-degree day on which the two teams played to a 3-3 tie Sept Sunday’s NCAA Tournament game will be much different Think soccer with a snowball on the sideline The forecast says it will be 27 degrees with a 15 mph wind when the Zips (11-3-5) and Panthers (9-4-5) take to the pitch in Akron Big East Bound:Akron Zips men's soccer team officially headed to Big East Conference Learning its fate:Akron soccer to host Pittsburgh on Sunday in NCAA Tournament “I think the game will take care of the weather for us,” Hudson native and Zips forward Will Jackson said It’s just focus on what we need to do to win Akron's 10-game unbeaten streak was snapped in the Mid-American Conference Championship game Nov. 12, and the Zips have had a lot of time to correct mistakes made from the 2-1 loss to Western Michigan. Unfortunately for the Zips, their two leading scorers — Jason Shokalook (9 goals, 6 assists) and Dyson Clapier (7, 7) — picked up red cards against the Broncos and won’t be available against Pitt. Although on the surface it looks like terrible news for Akron, the first time the Zips played the Panthers they were without Shokalook due to injury. Clapier was just coming back from a hamstring injury and played 64 minutes. “The first time we played them, we had experience playing without guys for a period a time,” Akron coach Jared Embick said. “I think that will help us. Instead of being, ‘Oh, my goodness, what are we going to do?’ We’ve already played those guys or, in Dyson’s case, we knew he wasn’t going to be able to give us 90 minutes. We’ll draw up on those experiences.” In the first meeting, Ryan Kingsford and Clapier gave the Zips a 2-0 lead early, but the Panthers scored two goals in the final 73 seconds of the first half and added another early in the second half to take the lead. Wan Kuzri Wan Kamal answered two minutes later for Akron and the match finished deadlocked. “Those two will be a big miss for us,” Kingsford said. “They’ve been big-time for us this season, but we’ve got a big group here with a lot of talent. It’s next man up, really. We’ve faced a lot of adversity with a lot of players missing out. We’ve had to shuffle the squad a little bit, but we’re ready. This is the time to shine.” That need to move the lineup around during the season has paid dividends. Kingsford (5 goals, 5 assists), Ashton Kamden (3, 5), Jackson (3, 4), Johnny Fitzgerald (4, 1) Wan Kamal (1, 7), Joel Sangwa (4, 0), Stefan Dobrijevic (3, 2), Josh Hallenberger (3,2) and Terence Okoeguale (2, 4) all have eight points are more heading in. That diversity in scoring will be needed against a Pitt team that has reached the NCAA Tournament four years in a row behind veteran seniors Valentin Noel (7, 3) and Jackson Walti (2, 0), and juniors Filip Mirkovic (3, 12) and Bertin Jacquesson (7, 3). Top-seeded Kentucky (14-0-5) or unseeded USF (9-6-4) wait in the wings, but for now Akron will look to a schedule loaded with national powers as the equalizer. The Zips have played six nationally ranked teams. They’ve also played tournament representatives Ohio State, Indiana, Florida International, Pitt, Western Michigan and Cleveland State this season, and are 3-2-3 in those matches. The Panthers have played 11 ranked teams. They’ve played tournament representatives Cleveland State, Akron, North Carolina, Marshall, Clemson, Denver and Georgetown, and are 3-1-3 in those meetings. “The schedules helps, definitely,” Kingsford said. “That’s why I came to Akron. It was the strength of schedule and putting yourself in a place to play against the best players. Pitt has some really good players on their team. We’ve been there and played them and are ready to play them again.” Contact Brad Bournival at bbournival@gannett.com and follow him on Twitter at @bbournival. 8vs0Saint Francis Akron Earns 8-0 Win Against Saint Francis September 24 | Men's Soccer In a battle of the preseason BIG EAST Conference favorites Akron will travel to Georgetown for a 1 p.m Senior midfielder Sam Tojaga knows what is expected of him and his teammates each time they put on a University of Akron men’s soccer uniform Whether it is a training session or a match Tojaga said Sunday night that the message from Zips coach Jared Embick is the same “Just keeping our dominant style on both sides of the ball staying balanced offensively and defensively because we know we have pieces offensively that can score goals like you saw [Sunday night],” Tojaga said after Akron earned a 4-1 win over Northern Illinois University 1-0-0) score four goals in the first half against the Huskies (3-4-3 0-2-0) and win their Mid-American Conference opener to have a fast start and maybe get a couple of goals and then we can really start to develop our system from there,” Tojaga said but we are very happy that what paid off in training this week translated right into the game.” The pop quizzes are over:Akron men's soccer team looks ready for Mid-American Conference play freshman Ashton Kamdem and junior Josef Paulus scored goals for the Zips as they dominated the Huskies “We had a really good week of training and I thought the game followed the training,” Embick said These guys have goals to win a couple of trophies at the end of the year and so far we have really shown that this last week leading into the first conference game.” Zip to the point:New-look for Akron men's soccer has team off to best start under coach Jared Embick Sam Tojaga returns to Akron starting lineupTojaga has overcome injuries and made his first start Sunday since the spring 2021 season that took place after the fall 2020 season was canceled because of the COVID-19 pandemic Tojaga missed all of the fall 2021 season due to a hip injury “It meant a lot and was very exciting,” Tojaga said of being back in the starting 11 “I had a lot of nerves going through my head at the time because it was a very frustrating process with a lot of ups and downs There were moments where I didn’t know if I would even be back out there again so to be back on the field with the team and to especially win in this type of environment − everything came together and it was a great night.” Embick was thrilled to watch Tojaga contribute in 59 minutes of playing time “For a guy that started in the national final as a freshman [in 2018] and started a lot of games in 2019 “You could see a little bit of his quality [Sunday night] as he is coming back He brings a lot of confidence and stability and just like him we have waited it out for so long no one really knowing if we were going to get to this moment “I went to him last week and said ‘It looks like in training you are ready “Now we have to get to the point where we build up his minutes and get him used to playing 90 He is a big part of what we hope to accomplish.” Victory in home opener:Josh Hallenberger, Dyson Clapier, Johnny Fitzgerald lead Akron to 3-1 soccer win over VCU Clapier scored his goal Sunday in front of his parents “They usually try to come once a year to see one game,” Clapier said it is great to see the family and I am happy to get one with them in the stands.” UA sophomore Malik Henry had an assist on Clapier’s goal with nifty a pass Sangwa netted his goal in the 14th minute following a free kick by Zips sophomore Wan Kuzri Wan Kamal Kamdem’s goal in the 19th minute came off of a deflection after Zips sophomore Jason Shokalook fired a shot off of the right post Paulus contributed his goal in the 39th minute after receiving a pass from sophomore Josh Hallenberger NIU’s goal came in the 89th minute after a UA defender accidently kicked the ball into the net UA freshman goalkeeper Mitch Budler saved NIU’s lone shot on goal “We came out with a lot of energy and intensity and I thought we were pretty sharp I think once you get a big lead sometimes the sharpness goes The goals didn’t follow in the second half but up until the last minute we didn’t really give anything away This was a good way to start the conference.” a reserve midfielder and Highland High School graduate was one of five players with local ties that played for the Zips on Sunday The other four were junior starter Will Jackson (Hudson) redshirt freshman reserve Sam Harter (Copley) and freshmen reserves Stefan Dobrijevic (Firestone) and Levi Stephens (Firestone) ● Akron’s next three matches are on the road at Bowling Green on Wednesday The Zips next home match is against Bowling Green on Oct Michael Beaven can be reached at mbeaven@thebeaconjournal.com Follow Beaven on Twitter at www.twitter.com/MBeavenABJ The University of Akron men's soccer team returned to "dominant soccer" in its 2021 season opening match Thursday night at FirstEnergy Stadium UA scored four goals in the first half against visiting Wright State and added three more in the score half to record a 7-1 victory Zips coach Jared Embick could not have scripted a better outcome as he watched his players dominate possession and dictate the tempo of the match against the Raiders UA's current players resembled players from past teams under Embick and his predecessor, Caleb Porter "I think you saw the potential of what we can do in the attack we can just be ruthless at times and dominant that is what we want to be and now we gotta regroup and show we can do it again "We have got some guys that have some potential to open up the game play and take people on and create and score goals I think you saw that tonight and they are only going to get better." Ryan Kingsford and Wan Kuzri Wan Kamal displayed that type of potential when they scored UA's first three goals took on two guys and put the ball into the back of the net," said Clapier Kingsford found the net in the 32nd minute and Wan Kamal scored off of an assist from freshman Jason Shokalook in the 35th minute "I like having the ball in specific areas," said Kingsford and it was a situation where it was a quick decision to think and a quick movement to shoot." Zips sophomore Ivan Nikolic scored the final goal in the first half in the 42nd minute off of an assist from Wan Kamal Clapier assisted on UA's first two goals in the second half when he connected with junior Renato Kauzlaric in the 52nd minute and Kingsford in the 65th minute.  Senior Diogo Pacheco netted UA's final goal in the 72nd minute off of a pass from Nikolic "I am really happy with the team," Clapier said "I thought we set the tone for the season."  UA freshman Malik Henry displayed speed and solid dribbling and passing in the midfield on several occasions Zips senior goalkeeper Will Meyer made one save and allowed one goal Embick trotted out a starting lineup that featured Meyer in goal; senior Daniel Strachan, junior William Portman, sophomore Will Jackson and freshman Jonas Buechte as defenders; Clapier, Henry sophomore Johnny Fitzgerald and freshman Samu Siemens-Brega in the midfield and Kingsford and Kauzlaric up top at forward The large lead allowed Embick to substitute regularly "I think we can only build from this as coach said but for us this is just a stepping stone and this is a start We are going to build and we are going to keep getting stronger and stronger and hopefully have more performances like this seven." Big offensive night for ZipsUA's seven goals Thursday represents the second-highest goal total for the Zips in a season opener in program history only surpassed by the 10 goals scored in a 10-0 victory over Cincinnati on Sept UA's men's soccer team continues to attract players from all over the world The Zips roster this year features players from the following countries: United States Follow him on Twitter at www.twitter.com/MBeavenABJ Redshirt senior Emil Jaaskelainen and the No. 13-ranked University of Akron men's soccer team (10-3-4 2-4-2) in a Big East Conference Tournament quarterfinal at 7 p.m The Zips won the Big East Conference regular season championship and are led by Jaaskelainen senior Malik Henry and redshirt Dyson Clapier Jaaskelainen enters the match leading NCAA Division I men's soccer with 20 goals This is Akron's second year in the Big East in men's soccer Check back for updates on tonight's match between No Emil Jaaskelainen scores two goals for the Zips and Victor Gaulmin nets one goal Akron will meet Georgetown in a Big East Conference Tournament semifinal at 7:30 p.m 5 seed Creighton 1-0 in a quarterfinal Sturday Akron men's soccer maintains lead over DePaul in Big East Conference Tournament quarterfinalAkron leads DePaul 3-1 with just under three minutes remaining in the second half Akron has five shots on goal and six corner kicks DePaul has one shot on goal and one corner kick Akron leads DePaul 3-1 with just under 15 minutes remaining in the second half DePaul has one shot on goal and no corner kicks DePaul men's soccer trims Akron's lead in Big East Conference Tournament quarterfinalDePaul's Logan Finnegan scores a goal with 26:04 to go in the second half Akron's Emil Jaaskelainen and Malik Henry with shots on goal that are either kicked or batted away Akron leads 3-0 with just under 38 minutes remaining in the second half Akron's Emil Jaaskelainen scores another goal with another header with 43:34 to go in the second half and the Zips lead 3-0 The Zips have two shots on goal and both went into the net Akron has one corner kick and DePaul has none Akron's Emil Jaaskelainen scores a goal with a header with 15:39 to go in the first half Beto Ydrach started the scoring sequence with a kick off of DePaul defenders and Jaaskelainen redirected the ball into the net for his 21st goal this season Akron's Victor Gaulmin scores a goal off of a pass from Malik Henry The Zips lead 1-0 with 18:59 remaining in the first half Akron men's soccer awarded a corner kickAkron's Victor Gaulmin sent in a corner kick with 27:32 remaining in the first half and it did not lead to a goal Akron 12th-year head coach Jared Embick is starting the following 11 players: redshirt junior goalkeeper Mitch Budler redshirt senior forward/midfielder Dyson Clapier senior forward/midfielder Malik Henry and redshirt senior forward Emil Jaaskelainen Freshmen Jack Roman and Nicholas Beier and juniors Stefan Dobrijevic and Daragh Reilly are key reserves has 20 goals and seven assists in his first season at Akron after being a two-time NEC Player of the Year during four seasons at Long Island Akron's Dyson Clapier has four goals and eight assists Victor Gaulmin has three goals and eight assists senior Wan Kuzri Wan Kamal has four goals and five assists and Stefan Dobrijevic has two goals and four assists Dobrijevic is a Firestone High School graduate Sophomore midfielder Noeh Hernandez leads DePaul with eight goals and nine assists Graduate forward Logan Finnegan is second on DePaul's squad in goals with six Senior Santiago Davila is DePaul's goalkeeper and Mark Plotkin is in his seventh season as the head coach at his alma mater Akron and DePaul meet for the third time in men's soccer on Saturday The Zips have a 2-0 edge in the series with a 4-0 victory in Chicago on October 19 and a 3-0 win last season at FirstEnergy Stadium in Akron Michael Beaven can be reached by email at mbeaven@thebeaconjournal.com With just four games left in the regular season the University of Akron men’s soccer team is having a bit of an identity crisis It’s not that the Zips don’t know how to win it’s just that they haven’t done it very consistently this season That unpredictability reared its head again Monday in a 0-0 double-overtime tie with Michigan “I don’t think it was the prettiest game to watch or to play in,” Zips coach Jared Embick said “Michigan came in and did what they did but I don’t think our energy level was nearly what it needs to be in these games to claim a victory “When you get into situations where every result matters you can play not to lose games teams we’ll play are very similar to Michigan.” 24 Akron (7-3-3) needs to figure out with Mid-American Conference games against Bowling Green Northern Illinois and Western Michigan and a nonleague matchup against Cleveland State remaining “It’s more maturity and probably a little bit of confidence,” Embick said “You can see us against some of the best teams and in the biggest games we’re very intense Then there’s some games where we don’t have the same intensity and energy you have to have that or your style of play just doesn’t come out I think that’s where we’re just a little immature We have to find ways to have back-to-back good performances and intensity That’s been frustrating for coaches and the team.” That was especially true against the Wolverines (6-5-3) who took everything Akron threw at them and turned it away “It has to be a constant desire and will to win,” Zips defender Daniel Strachan said “It’s getting to the end of the year and there’s not much time left maybe a result like this you can just move on and build from it We have to have put in the effort and make sure we’re communicating being accountable and being all the things that it takes to be a great team If there is a silver lining it’s that Michigan gave Akron a game it might see in the conference playoffs and NCAA Tournament The Wolverines took one less shot (11) than the Zips but put three on frame to Akron’s two The best attempt came from the Zips in the first overtime when forward Dyson Clapier crashed in from the right side Although it was an unfortunate result for Akron the good news is it won’t have long to sit on the tie with Bowling Green coming to town on Friday “Not every shot is going to come off easy,” Clapier said “You’re going to have to work for it sometimes they don’t give anything away for free You have to work hard and get the shots off the best you can “It’s starting to become crunch time The team is frustrated with the home performances but you can still turn it around the next four games.” Get Recruited Faster with a Player Profile on SoccerWire.com AKRON, Ohio – The University of Akron men’s soccer squad under the leadership of eighth-year head coach Jared Embick has announced a talented 10-member newcomer class that will hit the pitch for the Zips during the Spring 2021 campaign A midfielder from Layton, Utah, Clapier gained valuable playing experience with the Portland Timbers Academy and Portland Timbers 2 in the USL He made his USL debut with the Timbers 2 at the age of 17 and scored his first goal for the squad at the age of 18 Embick on Clapier – “Dyson is a talented winger and is a threat to score and create in the final third He has great attacking instincts and competitive spirit.” A goalkeeper from Decatur, Ga., Hangi gained valuable playing experience with the Atlanta United Development Academy TopDrawerSoccer.com ranks him 31st in the South Atlantic Region Embick on Hangi – “Josh is an athletic keeper  with great potential We see him as a player that has great talent Those attributes will help him develop into an outstanding keeper.” Embick on Harter – “He is a very well-rounded player I think he is further along in his development at this age than his brother Skye He is versatile and can play multiple positions but we see him as a midfielder that can help us control games on both sides of the ball.” A native of Irmo, S.C., Jones, a versatile center back has gained valuable playing experience with South Carolina United where a year ago he earned Elite Clubs National League all-conference honors as well as an invitation to the ECNL after helping his squad to conference and regional titles he also played for the SC United Bantams in the United Soccer League Two he earned All-State and All-Regional accolades as a junior at Dutch Fork High School He was also rated 24th in the South Atlantic Region by TopDrawerSoccer.com Embick on Jones – “We really like Paul’s ability to play out of the back and initiate our build-up play He is a very smart player and has the toughness to be a very good player for us He is just a player that fits our style and identity Embick on Metsack – “Nate is an athletic defender who can use his toughness and athleticism in the game to put out a lot of fires He will allow us to play a high line in the back His ability is a great compliment to our other defenders.” Meyer joins the Zips after playing his initial three campaigns at Louisville where he appeared in 15 career matches for the Cardinals nine shutouts and a 0.77 goals against average he started and made three saves in net en route to earning a shutout in a 0-0 double-overtime draw with Akron in the Elite Eight a contest which the Zips advanced to the College Cup on penalty kicks He posted a 0.37 goal against average in three NCAA Tournament games in 2017 including garnering shutouts versus Colgate and Akron including 56 matches overall and was named first-team All-Ohio Conference Player of the Year and First-Team All-Conference as a senior Embick on Meyer – “We are excited that we were able to convince Will to come back and finish his last year in our program He is a very smart and athletic keeper that has the ability to steal games for you from the keeper position I think he has potential to be one of the best keepers in college this year.”  A native of Fairview, Pa., Scott, a winger/right back has gained valuable playing experience with the Internationals Academy in the United States Development Academy, where he led his squad in scoring as a freshman with 16 goals. He also helped lead his Columbus Crew SC Academy U17 and U19 teams to the playoffs as a sophomore and junior as well as the knockout stage of the Development Academy Playoffs in 2018 Embick on Scott – “Nick is a tremendous athlete who brings speed and toughness and can really open up the game on the wing He is an aggressive player and can run all day He can play as a fullback or winger and is a player that is only going to get better and better in our program.”  A native of Erie, Pa., Shokalook, a versatile forward has gained valuable playing experience with the Internationals Academy in the United States Development Academy TopDrawerSoccer.com ranked him as the 12th-best forward in the Class of 2020 as well as sitting 48th overall in the IMG Academy 150 He was named to the Academy Select team and garnered an invitation to the U.S Embick on Shokalook – “A big-time goal scorer Jason has a chance to become a special player Every year he has played he has been one of the best goal scorers in the country in his age group” He returned to the Union Academy to finish high school where he was a 2018 United Soccer Coaches Youth Boys All-East Region Team selection and was rated by TopDrawerSoccer.com as a four-star forward and the No 17 forward in the nation as well as ranking No Temple scored seven goals in 12 appearances with the Philadelphia Union U-18/19 squad during the 2018-19 season while finishing second on the Union’s U-18/19s with 20 goals during the 2017-18 campaign Embick on Temple – “Tonny is transferring to us after a year at NC state We tried to get him coming out of high school and are excited he is coming to us now he is another player that is dangerous every time he has the ball in the final third He can open up the game for us and makes our attack even more dangerous.” A native of Columbia, S.C., Williams, a versatile forward/winger has gained valuable playing experience with the South Carolina United where he helped his squad to conference and regional titles a year ago skill and determination is best way to describe Damon but we feel he can develop into an impact player in the future He is a player to watch for us as he can play as a forward or an outside back.”  Tasker Wheeler heads to Marquette University Western Michigan men's soccer signed 5 recruits Michigan State signed four men's soccer recruits The Indiana Hoosiers added seven new recruits Notre Dame unveiled its 2021 signing class Join the SoccerWire College Soccer Recruiting Search Engine and learn how to be seen OVER 1 MILLION TIMES PER YEAR. This site uses cookies to give you the best possible experience but do not collect personal information. By continuing to use the site you agree that we can save cookies on your device. For more information, please read our privacy policy. University of Akron men's soccer coach Jared Embick wore a T-shirt under  his jacket Wednesday with the word 'RELENTESS' across his chest His players got the message with a spirited effort in a 2-1 victory over visiting Penn State at FirstEnergy Stadium The win came after UA lost 3-1 at home to Georgia State on Saturday "We have been talking about sticking with the process waking up and being focused on the next game and our goals," Embick said "You can't let setbacks affect you and I think tonight was a great example of 'Hey "I think everybody thinks you are just going to play well and carry it on for two or three months but with this schedule we have a lot of challenges and different games to prepare us but we gotta stay focused on what we can do." Embick said he ordered the T-Shirt from "our old friends at Amazon." Sophomore Ryan Kingsford and freshman Dyson Clapier scored goals in the first half to give the Zips a 2-0 lead at halftime Senior Dax Hoffman netted a goal in the second half for the Nittany Lions (8-4-1) to make things interesting with eight minutes to go but the Zips (7-3-2) regrouped and held on for the win "I thought in the first half we were awesome," Embick said "We were all over them and played really well I know that we were frustrated after the last game and we had a great opportunity Penn State is undefeated in the Big Ten and they are ranked For us to play like that after a frustrating game shows that we have a lot left and we are still committed to reaching our goals." shots on goal (5-3) and corner kicks (8-6) Zips senior goalkeeper Will Meyer made two saves and Nittany Lions junior goalkeeper Kris Shakes had three saves Kingsford's goal came in the 16th minute with freshman Malik Henry and sophomore Johnny Fitzgerald each getting an assist "We have had ups and downs for the past few games," Kingsford said I put so much pressure on myself and they have taken that off of me ... This is such a relief off my shoulders." Clapier made it 2-0 with his goal in the 20th minute following passes from senior Diogo Pacheco and Kingsford "I remember the ball going to Diogo and I heard Kingsford in the back of my ear telling me to spread to the box I just made my run and buried the ball into the back of the net." Hoffman's strike in the 83rd minute came off of a pass by senior Seth Kuhn "I liked our commitment to what our game-plan was because we knew if we weren't Penn State was going to be a team that could expose us," Embick said "We needed to be committed and we needed to move on from last game when we are fully committed every side of the ball for 90 minutes Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell Genes are tightly packaged when they are not activated and then unpackaged by chromatin remodeling machines when genes need to be turned on Mutations in chromatin regulating machines are a significant driver of cancer and other human diseases as the mutant chromatin regulators improperly unpackage and express genes Chromatin remodeling machines have been a longstanding focus of Brad Cairns, PhD, study lead author, who discovered the first chromatin remodeling machine in 1996. Cairns is a scientist at Huntsman Cancer Institute (HCI) and professor and chair of oncological sciences at the University of Utah (U of U) The Cairns Lab works to understand how chromatin impacts gene expression in humans and other organisms and provides instructions for cell growth An important aspect of this work is better understanding the role of chromatin in cancer and other diseases The major component of chromatin is nucleosomes which are similar to beads upon which DNA is wrapped like a string explaining why chromosomes look like beads on a string under a powerful microscope Cairns and colleagues wanted to know how these beads are moved along or removed from the DNA to unpackage and expose genes Previous work showed that chromatin remodeling machines have a motor-like component that drives the machine along the DNA The fuel for the cellular motor is called ATP the motor ensures that the right genes are properly unpackaged the wrong genes are unpackaged—and cancer or improper development results Cairns’s team wanted to understand how the motor of the machine is regulated "These really are machines: they contain a ‘gas pedal’ and a ‘clutch’ that together control whether and how the motor moves the machine along the DNA This new paper shows the gas pedal and clutch sit right on the motor and the cancer-causing mutations localize to the clutch and gas pedal itself making the motor hyperactive and unpackaging genes when it should not." The work reveals how factors in the cell can activate the machine to do its work at the right place and time Cairns and his colleagues used data on mutations in human tumors from the COSMIC cancer database the largest cancer genomics database in the world in order to study the human chromatin remodeling machine called BAF/PBAF BAF/PBAF is mutated in 20% of all human tumors They studied these human mutations using yeast as a model system This analysis revealed a structural hub that tells the motor when to engage (the clutch) and how fast to run along the DNA (the gas pedal) the team found a series of cancer mutations in an area of the hub that regulates the motor activity and thus ensures proper movement or removal of nucleosomes and proper gene expression These mutations in the regulatory hub of the motor created a hyperactive and dysregulated motor that improperly opens up chromatin The team’s findings shed light on a key regulatory behavior of healthy cells and explain how a set of cancer-causing mutations promote cancer Cedric Clapier, PhD a member of the Cairns Lab and research associate professor of oncological sciences This research was supported by the National Cancer Institute grants P30 CA042014 Fax number: 801-213-6048All clinical services and programs are part of University of Utah Health Hospitals and Clinics Copyright © 2025 University of Utah Health A stand of aspen trees along the popular Mid-Mountain trail near Deer Valley is experiencing extensive die-off Keith Clapier is a master arborist and was contracted to prepare a report about the area earlier this year The popular Mid-Mountain hiking and biking trail crosses Guardsman Pass Road above the new project Clapier explained that the aspen stand has been isolated on three sides by the Guardsman Pass and Twisted Branch roads for many years The process began decades ago when Guardsman Pass Road was constructed and later paved His report indicates the Mid-Mountain trail has caused no impact on the trees in the area Clapier said years of development in the area contributed to these aspen trees being isolated from their broader root system “So now it's completely fragmented," Clapier said "That's probably what was giving its life support because I think this column is part of that column on the other side It went all the way up to halfway up Hawkeye It’ll progressively get worse over time unless mitigated.” Clapier’s report identifies 276 aspens that should be removed with the bark easily peeling off and exposing the infection underneath Most are suffering from what’s called sooty bark canker fungus which quickly grows vertically up the tree Clapier said the fungus will eventually wrap they could fall during high winds and create hazards to people and property Clapier said the most significant impact is on the wildlife that doesn’t like entering areas surrounded by hard surfaces He said the area could recover if specific steps are taken “If they are going to be running skid steers and cement mixers and whatever in here they could protect the existing root system by buffering it with mulch and old sheet plywood," Clapier said you flush cut it [leaving stumps] and then just try to protect the root.” Aspen trees are connected in vast underground root systems Clapier said that when hiking or riding through an aspen forest He referred to the aspen forest in the Fish Lake area in central Utah “It’s the oldest in the world and it’s the largest organism on Earth I think it's somewhere around 1,000 acres or something this is roughly about 10 acres approximately That seems to be about the average size of a clone in the Wasatch Mountains but they can be anywhere from 1 to 10 acres in size.” Clapier recommended that 276 dead aspens be cut and removed from the site He said stumps should remain because they can stimulate growth and help remove the cells of the sooty fungus He suggests installing fencing around the living aspens and irrigating the land during the hottest driest months to alleviate stress from drought He also proposes that builders use designated construction routes to minimize hard-packing dirt and severing roots Clapier believes that if those recommendations are followed the root and remaining aspens could be preserved The Park City Planning Commission considered the findings in the March 9 meeting Montpellier Mediterranee Metropole and TaM Montpellier Tramway Line 5 is the fifth line of the tram network operating in Montpellier It is the first development since the completion of Line 4 in 2012 The 16km line is being developed by Montpellier Mediterranee Metropole (MMM) MMM has appointed Transports de l’agglomeration de Montpellier (TaM) Montpellier Tramway Line 5 development is part of MMM’s mobility plan aimed at improving the city’s overall transportation system and reducing mobility-related carbon emissions by expanding the tram and bus network Construction works on the project were initiated in 2019 and are expected to be completed in the second half (H2) of 2025 Line 5 will provide sustainable mobility for 80,000 passengers a day with trams operating at a frequency of one in six minutes The project will create 11,000 direct and indirect jobs it will improve the transit between research facilities including Campus Agropolis Centre national de la recherche scientifique and the National Institute of Health and Medical Research The new line will also offer an efficient alternative to car use and support new urban densification The Montpellier Tramway Line 5 will extend from Clapiers to Laverune to form a north/south-west diagonal complimenting the existing four lines of the tramway that form a star The north-south line will extend from Saint-Eloi to Clapiers while the south-west route will run from Saint-Denis to Laverune Line 5 will share 3km of its length with lines 1 Apart from enabling the creation of new green spaces Line 5 will connect ten existing green spaces within Montpellier including Parc Montcalm The new line will be accessible by bicycle with cycling paths and a pedestrian crossing being created Montpellier Tramway Line 5 connects Clapiers and Laverune passing through the communities of Prades-le-Lez and Montpellier offering high-quality connectivity to metropolitan France’s activity centres The route will include 27 strategic stations in research and university centres The project includes three significant phases of construction ensuring future renovations do not impact traffic on the line preparatory work began in the northern section of the line and will continue in the west allowing for diversion from current networks focuses on infrastructural improvements such as building new roads The final phase will focus on train tests and dry runs Montpellier Tramway Line 5 will be served by 22 CAF Urbos 100X bidirectional trams The CAF Urbos 100X line features seven module units with low floors for easy entry The trains will be 43.2m long and have a capacity of 304 passengers The trams will prioritise passenger comfort and safety with specially designed seats for urban transportation systems MMM is contributing €346m towards the development of Line 5 The remaining €94m is being funded by the Ministere de l’Economie Finance and Industrial and Digital Sovereignty and Atelier Garcia-Diaz was awarded the project management contract for the new line and project management group and is providing design services and works supervision as part of the consortium SYSTRA is an engineering and consulting group based in France and is providing engineering and project management services Construcciones y Auxiliar de Ferrocarriles, a rolling stock manufacturer, was awarded a €225m contract to supply rolling stock for the project in June 2022 The contract includes the supply of 60 trams with an option to add 17 more trams in the future and eight to boost reserves during maintenance activities A consortium led by Eurovia and Sogea Environnement was awarded a €32.5m contract in June 2023 to undertake infrastructure works for Line 5 Eurovia and Sogea Environnement are both subsidiaries of VINCI Construction Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network SALT LAKE CITY (KUTV) — Make-A-Wish Utah granted a unique gift for a six-year-old girl. They partnered with Ballet West to allow Evelyn Svete to live out her dream of performing as Clara in “The Nutcracker.” “I love being in the Nutcracker!,” said Evelyn after her matinee performance with Ballet West She got the idea of performing as Clara while in the hospital last year Svete was diagnosed with cancer the week before Christmas 2020 She saw Ballet West's Nutcracker on TV watching it on Christmas Eve and again on Christmas day hoping someday she could play the iconic role of Clara Eliza Clapier, a wish coordinator with Make-A-Wish Utah "Wishes give kiddos and their families the courage and strength to fight these illnesses,” said Clapier On show day her parents Margo and Kyle watched with tissues in hand "It felt really awesome to just revel in it To sit back totally watch her do her thing,” said Margo Svete Gliding gracefully across the stage and smiling as the price twirled her around "I was feeling excited and happy,” she said which makes sense as she has overcome even scarier situations her mom said she got really sick and lost a lot of weight the ballerina on stage is sparkling and strong it felt like there's a lot of joy that came with it and it helped with some of that relief of we've made it through step one at least,” said Kyle Svete I want to be the sugar plum fairy,” she said Metrics details The dynamic regulation of chromatin involves four subfamilies of ATP-dependent nucleosome-remodelling complexes: imitation switch (ISWI) switch/sucrose non-fermentable (SWI/SNF) and INO80 Each subfamily is specialized to preferentially achieve particular chromatin outcomes: assembly Diversity in the protein composition of remodellers enables their specific interaction with particular transcription activators all remodellers have a similar ATPase 'motor' that translocates DNA from a common location within the nucleosome The diverse specialized proteins and domains in each remodeller subfamily are also involved in detecting nucleosome epitopes which differentially regulate the conserved ATPase–translocase motor to achieve the various chromatin-remodelling outcomes We propose an 'hourglass' model of chromatin remodelling that involves convergence on a DNA translocation mechanism which is preceded and followed by remodeller diversity in terms of differential remodeller targeting and remodelling outcomes Remodellers are emerging as 'smart' machines that are informed about whether or how to utilize DNA translocation to conduct chromatin remodelling Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding ejection or the incorporation of histone variants suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies all chromatin-remodelling complex subfamilies contain an ATPase–translocase 'motor' that translocates DNA from a common location within the nucleosome we discuss (and illustrate with animations) an alternative unifying mechanism of chromatin remodelling which is based on the regulation of DNA translocation We propose the 'hourglass' model of remodeller function in which each remodeller subfamily utilizes diverse specialized proteins and protein domains to assist in nucleosome targeting or to differentially detect nucleosome epitopes These modules converge to regulate a common DNA translocation mechanism to inform the conserved ATPase 'motor' on whether and how to apply DNA translocation which together achieve the various outcomes of chromatin remodelling: nucleosome assembly Prices may be subject to local taxes which are calculated during checkout Cancer biology and NuRD: a multifaceted chromatin remodelling complex The biology of chromatin remodeling complexes Regulating the chromatin landscape: structural and mechanistic perspectives Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes ATP-dependent chromatin remodeling: genetics Becker, P. B. & Workman, J. L. Nucleosome remodeling and epigenetics. Cold Spring Harb. Perspect. Biol. http://dx.doi.org/10.1101/cshperspect.a017905 (2013) Identification of multiple distinct Snf2 subfamilies with conserved structural motifs Histone chaperones: assisting histone traffic and nucleosome dynamics Identification of a rapidly formed nonnucleosomal histone-DNA intermediate that is converted into chromatin by ACF a stable conformational isomer of the nucleosome ISWI is an ATP-dependent nucleosome remodeling factor Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor Removal of promoter nucleosomes by disassembly rather than sliding in vivo ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex This study demonstrated for the first time that SWR1C carries out nucleosome editing that involves H2A.Z Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A Distinct factors control histone variant H3.3 localization at specific genomic regions Direct observation of DNA distortion by the RSC complex DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC The RSC chromatin remodelling ATPase translocates DNA with high force and small step size Stepwise nucleosome translocation by RSC remodeling complexes Dynamics of nucleosome remodelling by individual ACF complexes References 23–26 investigate the size of the DNA step that occurs during DNA translocation by SWI/SNF remodellers ISWI induces nucleosome sliding on nicked DNA Chromatin remodeling by RSC involves ATP-dependent DNA translocation Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme References 28 and 29 demonstrated for the first time that chromatin remodellers act by DNA translocation Functional role of extranucleosomal DNA and the entry site of the nucleosome in chromatin remodeling by ISW2 A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes This work demonstrates that the ISWI ATPase is an intrinsically active DNA translocase that is regulated by 'inhibition of inhibition' of both ATPase activity and coupling H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast This work demonstrates that SWR1C interacts with nucleosomes at position SHL2 and that histone exchange requires DNA translocation Regulation of DNA translocation efficiency within the chromatin remodeler RSC/Sth1 potentiates nucleosome sliding and ejection This study shows that nucleosome ejection by the Sth1 ATPase is achieved through the upregulation of DNA translocation efficiency and that actin-related proteins are required by the remodeller RSC for nucleosome ejection ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer References 36 and 37 reveal the capacity of ISWI subfamily remodellers to perform nucleosome sliding Nucleosome mobilization catalysed by the yeast SWI/SNF complex This work showed for the first time that SWI/SNF subfamily remodellers carry out nucleosome sliding SWI/SNF chromatin remodeling requires changes in DNA topology Dynamics of ATP-dependent chromatin assembly by ACF Reaction cycle of the yeast Isw2 chromatin remodeling complex Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling Spatial contacts and nucleosome step movements induced by the NURF chromatin remodeling complex References 43 and 44 define the binding of the ISWI subfamily remodellers to extranucleosomal DNA and within the nucleosome two DNA helical turns from the dyad Chromatin remodelling: the industrial revolution of DNA around histones The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing Structure and mechanism of helicases and nucleic acid translocases The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor Structure of chromatin remodeler Swi2/Snf2 in the resting state Structure and regulation of the chromatin remodeller ISWI References 48–50 present the crystal structures of the Chd1 ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism Chromatin remodeling through directional DNA translocation from an internal nucleosomal site Histone octamer transfer by a chromatin-remodeling complex This was the first report of nucleosome ejection by SWI/SNF remodellers Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome References 53 and 55 demonstrate that DNA translocation occurs within the nucleosome The SnAC domain of SWI/SNF is a histone anchor required for remodeling The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor Extranucleosomal DNA binding directs nucleosome sliding by Chd1 No need for a power stroke in ISWI-mediated nucleosome sliding Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor GAL4 directs nucleosome sliding induced by NURF The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription factors Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF A critical epitope for substrate recognition by the nucleosome remodeling ATPase ISWI References 65–67 report the discovery and characterization of the activation of the ISWI remodeller by the histone H4 tail basic patch Two distinct mechanisms of chromatin interaction by the Isw2 chromatin remodeling complex in vivo Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme The ATPase domain of ISWI is an autonomous nucleosome remodeling machine The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler Structural analysis of the RSC chromatin-remodeling complex Structural analysis of the yeast SWI/SNF chromatin remodeling complex Structural studies of the human PBAF chromatin-remodeling complex Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex Structure of a RSC-nucleosome complex and insights into chromatin remodeling Architecture of the SWI/SNF-nucleosome complex Site-specific attachment of reporter compounds to recombinant histones Chromatin remodeling by nucleosome disassembly in vitro Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement The ATP-dependent remodeler RSC transfers histone dimers and octamers through the rapid formation of an unstable encounter intermediate Chromatin remodeling: insights and intrigue from single-molecule studies Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription Nucleosomes can invade DNA territories occupied by their neighbors SWI/SNF has intrinsic nucleosome disassembly activity that is dependent on adjacent nucleosomes Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity This study demonstrates nucleosome editing by the remodeller INO80C and that INO80C prevents the mislocalization of H2A.Z outside of gene promoters Involvement of actin-related proteins in ATP-dependent chromatin remodeling H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme Chromatin dynamics and the RNA exosome function in concert to regulate transcriptional homeostasis a histone H2A variant that poises repressed/basal promoters for activation through histone loss Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer Stepwise histone replacement by SWR1 requires dual activation with histone H2A This study describes the stepwise replacement of H2A with H2A.Z in nucleosomes by the remodeller SWR1C Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C References 99–101 present the latest structures of the remodellers INO80C and SWR1C The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex Assembly of the Arp5 (actin-related protein) subunit involved in distinct INO80 chromatin remodeling activities Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex Signals and combinatorial functions of histone modifications Chromatin remodeling: a marriage between two families SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF Structural basis of histone H4 recognition by p55 Double chromodomains cooperate to recognize the methylated histone H3 tail Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9 Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC Chromatin remodeling enzymes: taming the machines: third in review series on chromatin dynamics Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4 Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms A cooperative activation loop among SWI/SNF gamma-H2AX and H3 acetylation for DNA double-strand break repair SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2 Swi/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z This work was the first to show a regulatory role for H2A.Z in nucleosome remodelling by ISWI Modulation of ISWI function by site-specific histone acetylation This work was the first to demonstrate that chromatin remodellers can be regulated by a histone modification Histone H4-K16 acetylation controls chromatin structure and protein interactions ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4 A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription DNA looping facilitates targeting of a chromatin remodeling enzyme Remodeling the chromatin structure of a nucleosome array by transcription factor-targeted trans-displacement of histones Activation domains drive nucleosome eviction by SWI/SNF Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators References 139–141 present initial evidence that transcription activators can regulate chromatin remodelling Dynamic regulation of transcription factors by nucleosome remodeling UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF- INK4a locus esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function chromatin structure and the regulation of transcription Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus The ISWI chromatin remodeler organizes the hsromega ncRNA-containing omega speckle nuclear compartments The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex A long noncoding RNA protects the heart from pathological hypertrophy Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres Chromatin regulatory mechanisms in pluripotency ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor chromosome organization and DNA replication Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI The SANT domain: a unique histone-tail-binding module Domain architecture of the catalytic subunit in the ISW2-nucleosome complex Yeast Isw1p forms two separable complexes in vivo Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor Novel Mi-2 related ATP-dependent chromatin remodelers The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains The human Mi-2/NuRD complex and gene regulation CHD chromatin remodelers and the transcription cycle CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler This work presented the first structure of an ARP module bound to a remodeller HSA domain Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes SnapShot: chromatin remodeling: INO80 and SWR1 RVB1/RVB2: running rings around molecular biology Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants Crystal structure of a nuclear actin ternary complex EP400 deposits H3.3 into promoters and enhancers during gene activation Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks YY1 functions with INO80 to activate transcription A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair Crystal structure of the nucleosome core particle at 2.8 A resolution Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler Mechanism of chromatin remodeling revealed by the Snf2−nucleosome structure Concerted regulation of ISWI by an autoinhibitory domain and the H4 tail N-terminal tail Interdomain communication of the Chd1 chromatin remodeler across the DNA gyres of the nucleosome Download references This work was supported by the Howard Hughes Medical Institute (HHMI) (C.R.C the US National Institutes of Health (NIH) (GM60415 to B.R.C.; GM054096 and GM049650 to C.L.P.) Howard Hughes Medical Institute and Department of Oncological Sciences University of Massachusetts Medical School The authors declare no competing financial interests The composition of each subfamily of chromatin remodellers in Saccharomyces cerevisiae Monomeric DNA helicases and chromatin remodellers share a common mode of translocation involving a protein motor core formed by two RecA-like lobes (shown in light and dark orange) which bind the same strand of DNA with one lobe slightly ahead of the other These lobes sequentially bind and release DNA enabling an 'inchworming' mechanism of unidirectional movement in the 3′ to 5′ direction along the tracking strand In order to perceive how this property is applied to the nucleosome we change perspective and hold the translocating enzyme in a fixed position The DNA then appears to be pumped by the enzyme and undergoes rotation during translocation We now depict the RecA-like lobes as mittens that reciprocally move The physical step size of 1 base pair per ATP hydrolysis depicted here is based on crystal structures and biophysical measurements of translocation (which are 1 to 2 bp) by chromatin remodelling ATPases and related helicases and translocases This animation starts by depicting both the protein and DNA components of the nucleosome which is the fundamental unit of chromatin structure in eukaryotes The eight histone proteins are shown in green The canonical nucleosome core particle consists of 147 base pairs of DNA wrapped in 1.67 left-handed superhelical turns around a histone octamer though in this depiction the DNA is extended The nucleosome has a two-fold rotational symmetry along a feature called the dyad axis the thirteen histone-DNA contacts can be visualized (flashing white and then staying blue) to form a positively-charged staircase along the surface of the octamer upon which the negatively-charged DNA is wrapped and subsequently disassembled into the central H3-H4 tetramer (light green proteins) capped on each end by an H2A-H2B dimer (darker green proteins) the staircase of histone-DNA contacts is again revisited and the DNA re-wrapped along that staircase to form the nucleosome Here we depict how chromatin remodellers can conduct nucleosome sliding via monotonous DNA translocation and depict the DNA much shorter on one side to help illustrate subsequent DNA movement and extension this canonical nucleosome is bound and fully enveloped by RSC which has a large pocket of nearly perfect nucleosome dimensions the two orange RecA-like lobes bind to the DNA at a fixed position within the nucleosome the lobes perform directional DNA translocation by pulling in DNA from the proximal side of the nucleosome and pumping it toward the distal side the lobes function like DNA-grabbing mittens which undergo a cycle of inchworming along the DNA backbone sequentially grabbing and releasing the DNA translocating one base pair of DNA per ATP hydrolysis in which the DNA at the entry site moves in concert with DNA at the exit site A more sophisticated depiction involving sequential movement first on the distal size and then on the proximal side Here we depict how chromatin remodellers can conduct nucleosome sliding via sequential (or discontinuous) DNA translocation bind to nucleosomal DNA at a fixed position two helical turns from the dyad axis and perform directional DNA translocation by pulling in DNA from the proximal side of the nucleosome and pumping it toward the distal side Translocation creates DNA torsion and translational tension on both sides of the mittens – which in this animation in two sequential steps – as has been shown in the remodeller ISWI the extra DNA can propagate in a wave-like manner toward the distal exit side of the nucleosome by diffusion breaking histone-DNA contacts as it propagates (depicted by flashing lights) translocation also breaks histone-DNA contacts (also depicted as flashing lights) drawing DNA from the proximal linker into the nucleosome The result is histone octamer displacement generically referred to as nucleosome sliding We depict here the ISWI ATPase bound to a fragment of the Acf1 protein in an unfolded state The ISWI remodeller contains two RecA-like lobes which comprise the DNA translocating motor as well as three remarkable regulatory domains: AutoN and are therefore depicted in red under conditions where they inhibit ISWI for example in the folded structure in the absence of the nucleosome The order of domain interaction with the nucleosome is not known but for depiction here we display the initial binding of ISWI RecA-like lobes to the nucleosome followed by the binding of the HSS domain to the linker DNA on the proximal side The presence of the H4 tail (in light green) releases AutoN inhibition (notice the color change) via a competition mechanism the release of the NegC inhibition (also note the color change) and restoration of coupling occurs via change of conformation due to HSS binding the DNA Once released from its intrinsic inhibitions the RecA-like lobes perform DNA translocation this tension is resolved by DNA wave propagation the tension is constrained between the lobes and the HSS domain which is resolved by the HSS releasing from the linker DNA allowing DNA to be drawn into the nucleosome before rebinding This cycle results in the displacement of the histone octamer relative to the DNA Iterations of this cycle draw the adjacent nucleosome closer and closer until the adjacent nucleosome interferes with the binding of the HSS domain by steric hindrance When the HSS can no longer rebind linker DNA ISWI changes to a conformation in which HSS fails to antagonize the NegC domain and the H4 tail stops competing with AutoN resulting in the cessation of DNA translocation and the release of ISWI from the nucleosome the HSS functions as a 'molecular ruler' leaving the adjacent nucleosome at a fixed distance from the substrate nucleosome (termed nucleosome spacing) Sequential application of this mechanism by one or more ISWI/ACF complexes (as depicted) occurring on all nucleosomes on the template produces an array that results in all the nucleosomes being the same distance apart Actin and actin-related proteins (PDF 149 kb) In addition to the RecA-like lobes which comprise the DNA translocating motor the SWI/SNF remodeller ATPase subunit contains an HSA domain which binds a heterodimer of the Actin-Related Proteins The HSA region folds back and interacts with one of the RecA-like lobes The SWI/SNF motor subunit binds to the nucleosome two helical turns from the dyad and performs DNA translocation through an inchworming mechanism drawing in DNA from the proximal linker and pumping it towards the distal linker the flashing lights depict the breakage and reformation of histone-DNA contacts This results in the displacement of the histone octamer relative to the DNA Binding of the Actin-Related Proteins to the HSA domain greatly improves the efficiency of DNA translocation Efficient and forceful DNA translocation result in the rupture of several histone-DNA contacts Beyond the RecA-like lobes (shown in orange) the SWR1C histone exchanger motor subunit (termed Swr1) contains an HSA domain which binds the Arp4 and Actin heterodimer as well as a N-terminal domain for interaction with an H2A.Z variant-H2B dimer Swr1 binds two helical turns from the dyad and its N-terminus interacts with an H2A.Z variant-H2B dimer (shown in yellow-dark green) which stimulates Swr1 ATPase activity and DNA translocation The SWR1C exchanger apparently does not allow translocated DNA to pass to the distal side of the nucleosome perhaps due to the presence of a domain or protein that prevents additional DNA movement (shown in dark blue) only the histone-DNA contacts located on the proximal side of the nucleosome are destabilized promoting the removal of a canonical H2A-H2B dimer and the loading of the H2A.Z variant-H2B dimer Histone-DNA contacts are then restored by the DNA wrapping onto the newly-installed histone contact staircase (shown by flashing lights during re-wrapping) resulting in dimer replacement without any change in the translational position of the nucleosome A large protein complex that carries out the DNA replication process from the unwinding of double-stranded DNA to strand duplication by DNA synthesis prevent histone aggregation and that can promote either nucleosome assembly or nucleosome disassembly H3 and H4) that are most commonly assembled into nucleosomes during replication and that constitute almost all of the nucleosomes across the genome Differ by a few amino acids from canonical histones and are expressed at low-to-moderate levels and typically inserted into nucleosomes independently of replication; they create specific chromatin regions and functions Protein domains of helicases and remodellers similar in structure and sequence to the ATPase domain of the Escherichia coli DNA-binding protein RecA A measure of the extent of helical winding of the DNA strands around each other Often expressed as the number of base pairs of DNA per helical turn in B-form DNA A mechanical property of polymer stiffness A pseudo-two-fold symmetry element of the nucleosome core particle refers to one DNA wrap around the surface of the octamer it describes the amount of DNA that is translocated per ATP hydrolysis and/or the probability that the enzyme conducts a DNA translocation step per ATP hydrolysis cycle Nucleosome that lacks one histone H2A–H2B dimer Download citation Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Cellular & Molecular Biology Letters (2025) Sign up for the Nature Briefing newsletter — what matters in science The Col du Clapier-Savine Coche with Turin (upper left) off in the distance Creative Commons Attribution-ShareAlike 2.5 Generic Metrics details the secretory pathway kinase FAM20C phosphorylates the majority of secreted phosphoproteins Members of the family of FAM20C-related kinases phosphorylate secreted proteins and proteoglycans but the extent and mechanism of their action is unclear The authors characterized FAM20C and revealed that the secreted portion of this peptide is truncated that N-linked glycosylation is required for its correct folding and secretion and that it undergoes autophosphorylation Previous work suggested that FAM20C phosphorylates Ser in the motif S-X-E/pS (where X is any amino acid and p indicates phosphorylation) and the screening of a 198-peptide array showed that FAM20C strongly prefers Glu at the +2 position of this motif and those related to the vertebrate lonesome kinase family of secreted kinases suggesting that the specificity of FAM20C is unique among secretory pathway kinases A single kinase generates the majority of the secreted phosphoproteome Download references Reprints and permissions Download citation The pursuit of excellence — in scholarship leadership and citizenship — is what defines a Sterling Scholar in the state of Utah Each high school senior who is recognized and awarded has demonstrated knowledge Each student is required to present a portfolio of work in a specific category be interviewed by judges and advanced at the high school and finals levels one overall Sterling Scholar winner is chosen and announced at an awards ceremony each year The categories for the Northeast Region are Agriculture Science The nominees for each school are as follows: historians have argued over the route used by the Carthaginian general Hannibal to guide his army — 30,000 soldiers 37 elephants and 15,000 horses — over the Alps and into Italy in just 16 days conducting a military ambush against the Romans that was unprecedented in the history of warfare Such an achievement required careful planning and strategizing but with little physical evidence of the journey available today and few recorded details of the crossing uncertainty remains about how it was accomplished In 218 B.C., when the crossing took place, the powerful nations of Carthage and Rome were at each other's throats Hannibal did the unthinkable — he led an army through a mountain region spanning about 80,000 square miles (over 207,000 square kilometers) — and descended on Rome from the north The most obvious route for Hannibal to have taken through the Alps is called the Col du Clapier a lecturer in ancient history at Cardiff University in the U.K. but offered far quicker passage through the mountains Get the world’s most fascinating discoveries delivered straight to your inbox "That's key — it was the fastest route This also supports historical accounts by the Greek historian Polybius and who described Hannibal choosing "the highest paths" for his army Compounds that are found in horse manure were plentiful in the sediment an army-size group of horses likely relieved themselves while resting according to the filmmakers' statement.  on coins from Carthage depicting realistic representations of elephants the animals closely resemble the African species in the size and shape of their ears raising the possibility that the Carthaginians were importing their elephants from northern Africa Hannibal's elephants may have represented a smaller now-extinct subspecies of African elephant; historical accounts described northern African war elephants as fearful of the bigger Indian war elephants while modern Asian elephants are generally smaller than their African cousins Elephants require vast quantities of food — about 220 lbs (100 kilograms) per day — which the army would have needed to bring along with them as there wasn't anything for the animals to eat along the way But the elephants would likely have handled the terrain and the distance quite well as they frequently have to cover great distances and cross mountain passes in both Africa and in the Himalayas Ultimately, Hannibal's brazen maneuver — elephants and all — couldn't save Carthage, which Rome defeated in the Second Punic War (218 B.C his ambitious journey still fuels imaginations and raises intriguing questions about achieving the seemingly impossible — for people and for elephants "Secrets of the Dead: Hannibal in the Alps" airs April 10 at 8 p.m. EDT on PBS (check local listings) and is available to stream on April 11 via pbs.org/secrets and PBS apps Original article on Live Science Mindy WeisbergerSocial Links NavigationLive Science ContributorMindy Weisberger is an editor at Scholastic and a former Live Science channel editor and senior writer Mindy studied film at Columbia University; prior to Live Science she produced wrote and directed media for the American Museum of Natural History in New York City biodiversity and evolution appear in museums and science centers worldwide earning awards such as the CINE Golden Eagle and the Communicator Award of Excellence Her writing has also appeared in Scientific American The Washington Post and How It Works Magazine  Her book "Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind Control" will be published in spring 2025 by Johns Hopkins University Press Scientific consensus shows race is a human invention May's full 'Flower Moon' will be a micromoon Did Elizabeth Smart and her kidnappers spend several months last summer hiding out in Dry Canyon they could have lived in relative obscurity in that canyon's rarely traveled south fork Mountain bikers regularly frequent the lower portion of the main canyon because it's a fairly smooth portion of the Bonneville Shoreline trail which splits to the right about two miles up Salt Lake City police jealously guarded a primitive campsite Thursday afternoon located three miles from the University of Utah Hospital in the south fork of Dry Canyon It's almost a mile off the main trail in the area The mouth of this canyon is located about four miles northeast of the Ed Smart home The canyon is also found between the "U" block on the mountainside and the U Several reporters headed to a possible campsite were turned back by authorities Thursday afternoon "Turn around or you'll be arrested," a police officer yelled to two reporters as they approached a primitive camp in the upper canyon that was marked with some clothes and other items that helicopter news crews had seen from the air Keith Clapier of Parley's Summit was in Dry Canyon with his mountain bike and dog Thursday and said he's been in the area more than a hundred times "I've seen runaways up here," he said explaining he could find better places to hide but agrees there's so much oak brush in the canyon that the south fork would be a place where you would see few visitors they could come up in the canyon just after dark and probably never be noticed Clapier also found a sleeping bag and two pairs of old hiking shoes in the lower part of the canyon that someone had recently discarded He said there's a narrow cave in the canyon that could be used for shelter several seeps of water and a year-round spring of water near the mouth of the canyon Reporters also found the bones of two small animals along the upper south fork trail Almost all of the trail has a very gradual incline say there's another spring of water higher up the canyon Kelner's not surprised that someone could hide out in Dry Canyon not to be confused with a different canyon by the same name that's south of Little Cottonwood Canyon "There are a lot of possibilities up there to hide in," Kelner said "It's not on the beaten path." Green said he hasn't been in the area much the past eight years after retiring from a job at the U "A surprising number of people use it," he said more than three dozen mountain bikers alone used the lower canyon in a two-hour period Thursday afternoon Nichols of Salt Lake wrote the book "Trails of the Wasatch" in the late 1990s an old stove and bed parts in the upper portion of the south fork which eventually reaches the Black Mountain Ridge There are a few small patches of snow two or more miles up but otherwise no water is visible along the trail Kelner feels someone could survive there in the summer "The spring is well hidden," he said There are also some small mammals living in the area E-MAIL: lynn@desnews.com