ORLANDO, Fla. (Feb. 25, 2025) – Orlando City SC has acquired the SuperDraft Priority to forward Dyson Clapier from Sporting Kansas City, in exchange for the Lions’ natural second round pick in the 2026 MLS SuperDraft, it was announced today. Following the trade, Orlando City B has signed the winger to an MLS NEXT Pro contract through 2025, with a Club option in 2026.
"Dyson is a winger that has skills both on and off the ball that we truly feel will fit well within our Club and we’re excited to bring him to Orlando,” said Orlando City VP of Soccer Operations and Technical Director Ricardo Moreira. “He’s a domestic player that can add further depth for us across our whole ecosystem and we think this will be a great step for both the Club and the player.”
Clapier was selected out of the University of Akron 51st overall by Sporting KC in the 2024 MLS SuperDraft, returning to college for a fifth season. The Layton, Utah native scored 19 goals and provided 20 assists across five collegiate seasons at Akron from 2020-2024.
TRANSACTION: Orlando City SC acquires the SuperDraft Priority to forward Dyson Clapier from Sporting Kansas City in exchange for the Lions natural second round pick in the 2026 MLS SuperDraft. Following the trade, the Lions have signed Clapier to an MLS NEXT Pro contract with Orlando City B through 2025, with a Club option in 2026.
Sporting Kansas City announced today that the club has acquired a natural second-round pick in MLS SuperDraft 2026 from Orlando City SC in exchange for the SuperDraft Priority to forward Dyson Clapier.
Sporting selected Clapier with the 51st overall pick in MLS SuperDraft 2024, securing his SuperDraft Priority through the end of 2025. Clapier returned to the University of Akron for a fifth college season in the fall of 2024, then joined Sporting KC for the first leg of the club’s 2025 preseason in Miami, Florida.
Clapier, 22, had 19 goals and 20 assists across five collegiate seasons at Akron from 2020-2024.
Sporting will visit Inter Miami CF tonight in the decisive second leg of Round One in the Concacaf Champions Cup, looking to overturn a 1-0 aggregate deficit and advance to the Round of 16. Kickoff is set for 7 p.m. CT at Chase Stadium in Fort Lauderdale, Florida, with live coverage on FS2, TUDN and ViX.
Transaction: Sporting Kansas City (MLS) acquires a natural second-round pick in MLS SuperDraft 2026 from Orlando City SC (MLS) in exchange for the SuperDraft Priority to forward Dyson Clapier.
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Note: Players under contract to Sporting Kansas City at this time are not included on this list, the exception being players loaned outside of Kansas City.
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The player immediately moves to the Orlando City B roster for this season
Forward Dyson Clapier comes to Orlando City SC from Sporting Kansas City
With hot prospect Yutaro Tsukada out for the season – first team player Wilder Cartagena is also out – the Lions front office is watching the B squad closely in case help is needed during the heat of the season
Those players need to be kept sharp in competitive conditions
Vice President of Soccer Operations and Technical Director Ricardo Moreira said the organization is looking to add Clapier to the Orlando City ecosystem for depth
The club acquired him through his SuperDraft Priority
Clapier was selected by Kansas City in the 2024 SuperDraft out of the University of Akron
but returned to college for a fifth season
He scored 19 goals plus 20 assists throughout his five seasons
As he didn’t sign with the league, Clapier was placed on Sporting Kansas City’s SuperDraft Priority List
so Orlando City traded the club a natural second-round pick in the 2026 SuperDraft
Sporting would have lost priority rights to sign the player on Dec
Scouts don’t have to travel far to assess strong talent for the first team as they develop and compete with Orlando City B
Midfielders Gustavo Caraballo and Colin Guske are on short-term contracts with the first team
Awaiting Clapier on the pitch are highly regarded midfielder Jhon Solis and defender Zakaria Taifi
As Orlando City SC picks up the speed and passing accuracy to start defeating their opponents
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Vice President of Soccer Operations and Technical Director Ricardo Moreira said the organization is looking to add Clapier to the Orlando City ecosystem for depth
As he didn’t sign with the league, Clapier was placed on Sporting Kansas City’s SuperDraft Priority List
Scouts don’t have to travel far to assess strong talent for the first team as they develop and compete with Orlando City B. Clapier will be in a strong, competitive environment.
Midfielders Gustavo Caraballo and Colin Guske are on short-term contracts with the first team. Awaiting Clapier on the pitch are highly regarded midfielder Jhon Solis and defender Zakaria Taifi.
As Orlando City SC picks up the speed and passing accuracy to start defeating their opponents, it will be a season worth experiencing.
•\tClub got the SuperDraft Priority, then the player•\tOrlando City B gains a striker prospect•\tForward will develop for organization depth
This afternoon, Sporting KC announced their preseason schedule and roster for at least the start of the 2025 preseason
The first phase that started on Sunday will continue through the 29th of January in Miami
Kansas City will then head to Southern California to finish out preseason from February 2nd through the 12th before kicking off the 2025 season at Children’s Mercy Park on the 18th of February against Inter Miami in the CONCACAF Champions Cup
Sporting currently have three games scheduled in each location with games against Florida International University
and Charlotte FC in Miami and games against New York City FC
and the Las Vegas Lights while in California
Also included in the release was an updated roster for Sporting KC that includes numbers for the new players on the team
None of Kansas City’s returning players have new numbers at this point but Sporting’s four new players all have their numbers:
Finally, the announced roster also included ten players that were invited to join the team for preseason. One note pointed out by Daniel Sperry
Leon Koehl has chosen to return to Maryland
Sporting’s 2025 first round draft pick
He played in 20 games for Indiana in the 2024 college season
He can play both center back and right back
Anthony Samways: Sporting’s second round draft pick in the 2025 draft out of Ohio State
Dyson Clapier: Sporting’s second round pick in the 2024 SuperDraft
Clapier elected to return to school for the 2024 season instead of turning pro and is now in camp with Sporting
Jan Jurcec: The one trialist in camp with no previous ties to Sporting. The 24 year old Jurcec comes to Kansas City having last played with SCR Altach in the Austrian Bundesliga
Jurcec played over 60 games scoring 2 goals and adding 3 assists playing on the right side as a winger
But he has been without a club since the end of the last European season
Jurcec played with NK Kustosija Zagreb in his home country of Croatia
He also made a handful of appearances for Croatia’s U21 team
Carson Klein: The former Sporting KC II player and son of Sporting Legend
Chris Klein joins the first team as a trialist for preseason this year
Klein made 11 appearances for Sporting KC II in the 2024 MLS Next Pro season
9 of them starts after joining SKCII halfway through the 2024 season
Klein was one of seven players who were out of contract at the end of the 2024 MLS Next Pro season
Cielo Tschantret: The lone Sporting KC II contracted player to join SKC for this phase of preseason
Tschantret signed his first pro contract with Sporting KC II ahead of the 2024 MLS Next Pro season
he’d played with the team in 2023 on an academy contract
During that stretch he’s scored 3 goals and added an assist
Tschantret earned a spot on the bench for the first team in the 2024 Leagues Cup game against the Chicago Fire
Johann Ortiz: A Sporting KC academy player who spent time in 2024 with Sporting KC II on an academy contract
Leo Christiano: Another Sporting KC academy player who played with SKCII on an academy contract
Christiano played for Sporting in both the 2023 and 2024 MLS Next Pro seasons
In those two seasons he’s made 17 appearances
Jacob Molinaro: The third Sporting KC academy player on the list of players invited to camp
like the other two academy players played with Sporting KC II last year on an academy contract
Molinaro played 10 games for SKCII last year recording a 3-5-2 record for KC
Sebastian Cruz: Former Sporting KC academy player
Cruz is in camp as a trialist with the first team
Cruz has spent the last two years under contract for SKCII
39 starts scoring 10 goals and adding 7 assists
He’s also played with the first team
having been called up in the 2023 season for KC’s US Open Cup run
appearing in KC’s 3-0 win over Tulsa Athletic
Cruz made the bench again for the first team in 2024
during the Leagues Cup being available for both the games against the Chicago Fire and Columbus Crew but didn’t appear in either game
Given how the invitee list has worked in past years it’s likely that this list will change as the preseason continues
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University of Akron men's soccer players Jason Shokalook
Malik Henry and Dyson Clapier were selected in the 2023 MLS SuperDraft on Tuesday
32nd and 33rd Zips to be drafted in an MLS SuperDraft
Akron's run of draft picks has been under three coaches: Ken Lolla
Shokalook was selected with the sixth selection of the second round (35th overall) by Chicago Fire FC
Henry was drafted with the 10th pick of the second round (39th overall) by CF Montreal and Clapier was tabbed with the 22nd pick of the second round (51st overall) by Sporting Kansas City
Shokalook earned United Soccer Coaches All-America second-team honors in 2023
He started all 17 games in which he appeared for UA (9-2-7
Shokalook totaled 26 goals and 17 assists in 59 matches (41 starts)
Henry helped the Zips lead the Big East with 10 shutouts and a 0.56 goals against average
Henry had 12 assists in 50 matches (47 starts)
Clapier totaled 14 goals and 12 assists in 57 matches (48 starts)
50 Akron players have gone on to play professionally either in Major League Soccer
Michael Beaven can be reached at mbeaven@thebeaconjournal and is on Twitter at @MBeavenABJ
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Most of the apartments in 333 East 68th Street
a red-brick Neo-Georgian building situated on St
are fairly staid — tastefully renovated with austere finishes and hints of character from an odd chandelier or molded fireplace
six-room apartment has been renovated by WQB Architecture to resemble a chateau in Provence
two carved-marble wood-burning fireplaces; herringbone floors; a hand-painted mural of a French Baroque garden landscape depicting classical marble statues
and lush but manicured greenery in the stairway leading to the library; an arch painted with sirens between the living room and second bedroom; and a robin’s-egg-blue coffered ceiling with intricate crown moldings and hand-painted gilded detailing
Price: $4,995,000 (monthly maintenance: $7,432)
Street view: A tree-lined one-way street of pre-war high-rise apartment buildings with a park and school
Listed by: Paula Del Nunzio / Brown Harris Stevens
The large dining room is clad in intricately carved wood paneling with a delicate floral-and-lattice-patterned ceiling
Built-in bookcases and hand-painted murals of angels and foliage climb the 13-foot ceilings of the wood-paneled office and the loft with a built-in captain’s bed
No surface of this apartment has been left unpainted
including painted lace trim and Corinthian columns
The unit occupies the entire 15th floor of the eastern side of the building
allowing for a large landscaped terrace that wraps around the apartment on three sides with views of the East River and the Chrysler Building
was designed to be “a regular Park Avenue type building” but at about half the price
the 22-year editor of Vanity Fair and one of the founding trustees of the Museum of Modern Art (who was once described by Amy Fine Collins as “the most cultivated
He lived in one of the penthouses for a time in the ’30s
but based on the historical archive alone it’s difficult to be certain which
The other penthouse apartment in the building is on the ninth floor — also a six-room triplex with private terraces
including a stint as the president of the now defunct luxury Hôtel Plaza Athénée
a five-star hotel on East 64th that features similarly intricate murals and crown moldings
and he has been active in many of the city’s French American social clubs
His love of French culture is more than apparent in his painstaking renovations
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It has become quite common to hear the names of University of Akron players when the MLS has its SuperDraft
but here’s the rub — Henry and Clapier are coming back to Akron
“It’s always an exciting day to see players get picked up and the interest others have in the program,” Zips coach Jared Embick said
“The MLS is starting to take steps like other sports where you can be drafted and still go to school and the pro team retains your rights until you graduate.”
That’s the clause Henry and Clapier used as both are on track to graduate in December
The 5-foot-11 forward came into last season with high hopes as a first team All-Big East preseason selection and a MAC Hermann Trophy candidate
4 on TopDrawerSoccer.com’s preseason 100 list
an injury limited Clapier to eight starts and 12 games
in which he registered two goals and two assists
“It was a great feeling to get drafted and be around my family to celebrate that,” Clapier said
but we have some unfinished business in Akron
it’s better to come back off that injured year and come back ready.”
The Zips put together a 9-2-7 season in 2023 and lost just one regular-season game
They spent a solid portion of the year ranked but their name wasn't called when the brackets came out for the NCAA Tournament
it hurt not making the tournament,” Clapier said
Henry echoed Clapier’s feeling after a season of just misses
The 5-7 defender helped the Zips to 10 shutouts and a 0.56 goals against average in 14 games and 13 starts and logged four assists
That earned him the 39th pick in the draft
“I think coming back to Akron was the best decision I could make,” he said
“I’ll be able to get my degree in the fall and I feel like the Zips have something to prove
We’re going to give them no reason to leave us out.”
When Henry does play for Montreal he’ll have a Cleveland Browns vs
Pittsburgh Steelers situation on his hands
so in a sense Henry is changing allegiances
It’s really great to play in the MLS in the country I was born in.”
Shokalook started 17 games and led the Zips in goals (14)
shots on goal (41) and game-winners (3) and was seventh in the NCAA in goals
he totaled 26 goals and 17 assists and started 41 of the 59 games in which he played
That earned him the 35th pick by Chicago and a future in the MLS
“He’s got a professional frame at 6-1,” Embick said
good speed and has a lot of potential to offer
get on the end of things and stretch the game
Contact Brad Bournival at bbournival@gannett.com and follow him on Twitter at @bbournival
Sporting Kansas City selected three college standouts on Tuesday in MLS SuperDraft 2024 presented by adidas
picking goalkeeper Ryan Schewe from Georgetown University with the 22nd overall pick in the first round
forward Dyson Clapier from the University of Akron with the 51st overall pick in the second round and defender Jonathan Robinson from Western Michigan University with the 80th overall pick in the third round
With the 22nd pick of the 2024 MLS #SuperDraft, #SportingKC selects goalkeeper Ryan Schewe from @GeorgetownHoyas. pic.twitter.com/FdhOlX14Rf
Schewe attended the adidas MLS College Showcase earlier this month -- recording the highest vertical -- and was selected in the first round after two outstanding seasons in goal at Georgetown University while also featuring for Apotheos FC (NPSL) in 2022 and the Westchester Flames (USL League Two) in 2023
The 6'4" goalkeeper appeared in 29 matches during the 2022 and 2023 collegiate campaigns
recording 86 saves and 12 shutouts with a 20-4-4 record and a 0.79 goals against average
Schewe was a Second Team All-BIG EAST selection as a junior after earning the starting spot and leading the conference in save percentage and shutouts
the 21-year-old senior guided the Hoyas to the BIG EAST regular season championship while leading the conference with the lowest goals against average and the most clean sheets
He earned BIG EAST Goalkeeper of the Year and First Team All-BIG EAST honors
as well as United Soccer Coaches Second Team All-East Region recognition
With the 51st pick in the second round of the 2024 MLS #SuperDraft, #SportingKC selects Dyson Clapier from @ZipsMSoc. pic.twitter.com/KeAFwNTqCK
Clapier starred at the University of Akron for the past four years
tallying 14 goals and 12 assists in 57 appearances
before being selected in the second round of the MLS SuperDraft
Clapier was a Second Team All-MAC selection in 2021 and led the Zips in assists in 2022
earning Third Team All-America and First-Team All-North Region honors from United Soccer Coaches along with First Team All-MAC recognition in addition to an invite to the adidas MLS College Showcase
the 21-year-old forward played two seasons in the USL Championship for Portland Timbers 2 in 2019 and 2020 - debuting at the age of 17 - before moving to USL League Two side Park City Red Wolves in 2021
Clapier won the College Spring League Golden Boot with five goals in four matches and most recently Clapier joined NPSL club Akron City FC in 2023
With the 80th pick in the third round of the 2024 MLS #SuperDraft, #SportingKC selects defender Jonathon Robinson from @WMUMensSoccer. pic.twitter.com/ciyy7k3RJ5
Coming off a stellar season in which he tied the school record and finished second in the NCAA with 13 assists
Robinson was selected in the third round of the MLS SuperDraft
The 22-year-old defender captained Western Michigan University to the regular season and Missouri Valley Conference tournament titles while earning First Team All-MVC and First Team All-West Region honors in 2023
while also debuting for the Flint City Bucks in USL League Two
Sporting KC Vice President of Player Personnel Brian Bliss
On second round selection Dyson Clapier…
On third round selection Johnson Robinson…
We always try to target a few positions. We didn’t have a ton of openings in our roster in terms of numbers wise. Obviously, we he had a little bit of a hole in the middle of the midfield and at the backup goalkeeper position. The goalkeeper was a little bit more targeted, and the others were more of a best available.
I am just so thankful for this opportunity. I am celebrating with my family right now and I am extremely excited to see all that awaits.
I am extremely grateful. I would like to thank everyone who has gotten me to this point and I am ready to work.
It was a crazy experience waiting, one of the worst waits of my life. Around the holidays, there's no better present than being drafted. I'm happy to be selected by KC and I can't wait to meet the team.
BRADENTON, Fla. (April 15, 2025) – Orlando City B (3-2-1, 11 points) battled Inter Miami CF II (2-3-1, 7 points) at IMG Academy Stadium on Tuesday night. The Lions suffered their second loss of the season, despite a late goal by Shak Mohammed and push for the equalizer.
Despite the loss, Orlando City B received contributions from all over the pitch in the match with goals from defender Tahir Reid-Brown and midfielder Shak Mohammed, as well as assists from OCB midfielder Riyon Tori and forward Dyson Clapier.
At the end of second-half stoppage time, Orlando City midfielder Shak Mohammed was able to get OCB back within a goal after converting his penalty kick, but time ran out before the Lions could find their second equalizer of the night. Mohammed now sits tied for second in MLS NEXT Pro at four goals on the season.
The Lions will return home to host New York Red Bulls II on Sunday, April 27. The game will stream live on MLSNEXTPro.com, with kick-off set for 7 p.m. ET at Osceola County Stadium in Kissimmee, Florida.
The University of Akron men's soccer team opened the 2023 season in impressive fashion Thursday night at FirstEnergy Stadium
The Zips were in a familiar position all evening as they attacked and pursued goals against overmatched Niagara
Will Jackson, Dyson Clapier, Johnny Fitzgerald, Gyuwon Chong, Josef Paulus and Stefan Dobrijevic each scored a goal to lead Akron to a 6-0 win before a crowd of 1,174
"We need to build off of this," Jackson said
We came in with a defensive mindset and I think we achieved our goal with a shutout."
The Zips dominated play and held an edge in shots (27-3)
shots on goal (13-2) and corner kicks (6-2)
"The boys executed the plan perfectly," UA associate head coach Ger Coppinger said
Coppinger led the Zips as head coach Jared Embick
assistant Michael Nanchoff and junior forward Jason Shokalook each served a one-game suspension that carried over from last season's NCAA Tournament loss to Pittsburgh
Hudson graduate Will Jackson propels Akron to men's soccer winJackson
opened the scoring in the fourth minute with his goal
Paulus and Fitzgerald assisted on the strike after Clapier started the sequence with a shot on goal
"I say thanks to my teammates," said Jackson
"It was a bouncing ball in the box and I think we won two or three 50-50s
popped out to us and it was an easy finish from there
a junior who was named to the 2023 Missouri Athletic Club's Hermann Trophy Watch List before the match
netted his goal in the 30th minute with junior Jonas Buechte and senior Joel Sangwa each getting an assist
"The second goal really opened everything up for us," Coppinger said
"We were able to play our game — get after them
found the net in the 43rd minute off a pass from junior Wan Kuzri Wan Kamal
"This was mission accomplished and onto the next one," Fitzgerald said
"I am always happy to contribute to the team when I can on the scoresheet but
Firestone alum Stefan Dobrijevic score goals in Akron men's soccer winSeniors Sam Tojaga and Alejandro Varela assisted on the goal by Chong
a senior and 2019 Highland High School graduate
netted his goal in the 58th minute off a free kick from 22 yards out
a sophomore and 2022 Firestone High School graduate
converted a penalty kick in the 72nd minute
sophomore Rui Reis and 2023 Wadsworth High School graduate Jackson Herbert were also active in Akron's attack that led to Zips freshman goalkeeper Seth Wilson facing and saving only two shots
"What was great was the amount of guys we got on the field and the level never dropped," Coppinger said
University of Akron men's soccer player Dyson Clapier made the most of his one shot on goal Monday night at FirstEnergy Stadium
Malik Henry sent a pass to Clapier in the 61st minute and the Layton, Utah, native finished his lone scoring chance to propel Akron to a 1-0 win over the University of Vermont in a matchup of two teams ranked in the top 25
"I saw Malik flip the ball back post and as soon as it went over everyone's head
and no way I am missing that,'" said Clapier
who is one of 37 players on 2023 Missouri Athletic Club's Hermann Trophy Watch List
I kicked the corner flag and celebrated with my team."
Vermont (1-1), ranked No. 7 in the country in the TopDrawerSoccer.com poll, generated five shots on goal, but Akron keeper Seth Wilson denied each one
were a national quarterfinalist in last year's NCAA Tournament
"This is a very good win," Akron coach Jared Embick said
"Vermont has got the belief and experience back from the Elite Eight
and you could feel that I think in the start
we were probably a little too tense and then we got a little better as the half went on
"I thought in the second half we were excellent
we really took control and played a lot of the soccer we are capable of playing
Seth was outstanding in goal and the back four was awesome."
"We showed a lot of resilience that we can grind out a tough game against a big, physical team," Henry said. "We showed that we can play our brand of soccer against basically anybody."
Said Clapier: "This shows that we can compete with anyone in the nation. This is a signature win against a top 10 opponent. Vermont is a heck of a team."
Michael Beaven can be reached at mbeaven@thebeaconjournal and is on Twitter at @MBeavenABJ.
4vs0VCU
Akron started the scoring when senior Jonas Buechte (Rantigen, Germany) notched his first goal of the season in the 26th minute (25:04) knocking in the deflection off of a free kick from redshirt senior Victor Gaulmin (Guipavas
The Zips assumed a 3-0 edge on Clapier's 56th-minute (55:12) goal, his second of the season. Redshirt senior Emil Jaaskelainen (Bolton, England) and senior Malik Henry (Hamilton
the 16th-seeded University of Akron men’s soccer team is playing Pitt for the second time this season but
unlike the 72-degree day on which the two teams played to a 3-3 tie Sept
Sunday’s NCAA Tournament game will be much different
Think soccer with a snowball on the sideline
The forecast says it will be 27 degrees with a 15 mph wind when the Zips (11-3-5) and Panthers (9-4-5) take to the pitch in Akron
Big East Bound:Akron Zips men's soccer team officially headed to Big East Conference
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“I think the game will take care of the weather for us,” Hudson native and Zips forward Will Jackson said
It’s just focus on what we need to do to win
Akron's 10-game unbeaten streak was snapped in the Mid-American Conference Championship game Nov. 12, and the Zips have had a lot of time to correct mistakes made from the 2-1 loss to Western Michigan.
Unfortunately for the Zips, their two leading scorers — Jason Shokalook (9 goals, 6 assists) and Dyson Clapier (7, 7) — picked up red cards against the Broncos and won’t be available against Pitt.
Although on the surface it looks like terrible news for Akron, the first time the Zips played the Panthers they were without Shokalook due to injury. Clapier was just coming back from a hamstring injury and played 64 minutes.
“The first time we played them, we had experience playing without guys for a period a time,” Akron coach Jared Embick said. “I think that will help us. Instead of being, ‘Oh, my goodness, what are we going to do?’ We’ve already played those guys or, in Dyson’s case, we knew he wasn’t going to be able to give us 90 minutes. We’ll draw up on those experiences.”
In the first meeting, Ryan Kingsford and Clapier gave the Zips a 2-0 lead early, but the Panthers scored two goals in the final 73 seconds of the first half and added another early in the second half to take the lead.
Wan Kuzri Wan Kamal answered two minutes later for Akron and the match finished deadlocked.
“Those two will be a big miss for us,” Kingsford said. “They’ve been big-time for us this season, but we’ve got a big group here with a lot of talent. It’s next man up, really. We’ve faced a lot of adversity with a lot of players missing out. We’ve had to shuffle the squad a little bit, but we’re ready. This is the time to shine.”
That need to move the lineup around during the season has paid dividends.
Kingsford (5 goals, 5 assists), Ashton Kamden (3, 5), Jackson (3, 4), Johnny Fitzgerald (4, 1) Wan Kamal (1, 7), Joel Sangwa (4, 0), Stefan Dobrijevic (3, 2), Josh Hallenberger (3,2) and Terence Okoeguale (2, 4) all have eight points are more heading in.
That diversity in scoring will be needed against a Pitt team that has reached the NCAA Tournament four years in a row behind veteran seniors Valentin Noel (7, 3) and Jackson Walti (2, 0), and juniors Filip Mirkovic (3, 12) and Bertin Jacquesson (7, 3).
Top-seeded Kentucky (14-0-5) or unseeded USF (9-6-4) wait in the wings, but for now Akron will look to a schedule loaded with national powers as the equalizer.
The Zips have played six nationally ranked teams. They’ve also played tournament representatives Ohio State, Indiana, Florida International, Pitt, Western Michigan and Cleveland State this season, and are 3-2-3 in those matches.
The Panthers have played 11 ranked teams. They’ve played tournament representatives Cleveland State, Akron, North Carolina, Marshall, Clemson, Denver and Georgetown, and are 3-1-3 in those meetings.
“The schedules helps, definitely,” Kingsford said. “That’s why I came to Akron. It was the strength of schedule and putting yourself in a place to play against the best players. Pitt has some really good players on their team. We’ve been there and played them and are ready to play them again.”
Contact Brad Bournival at bbournival@gannett.com and follow him on Twitter at @bbournival.
8vs0Saint Francis
Akron Earns 8-0 Win Against Saint Francis September 24 | Men's Soccer
In a battle of the preseason BIG EAST Conference favorites
Akron will travel to Georgetown for a 1 p.m
Senior midfielder Sam Tojaga knows what is expected of him and his teammates each time they put on a University of Akron men’s soccer uniform
Whether it is a training session or a match
Tojaga said Sunday night that the message from Zips coach Jared Embick is the same
“Just keeping our dominant style on both sides of the ball
staying balanced offensively and defensively because we know we have pieces offensively that can score goals like you saw [Sunday night],” Tojaga said after Akron earned a 4-1 win over Northern Illinois University
1-0-0) score four goals in the first half against the Huskies (3-4-3
0-2-0) and win their Mid-American Conference opener
to have a fast start and maybe get a couple of goals and then we can really start to develop our system from there,” Tojaga said
but we are very happy that what paid off in training this week translated right into the game.”
The pop quizzes are over:Akron men's soccer team looks ready for Mid-American Conference play
freshman Ashton Kamdem and junior Josef Paulus scored goals for the Zips as they dominated the Huskies
“We had a really good week of training and I thought the game followed the training,” Embick said
These guys have goals to win a couple of trophies at the end of the year and so far we have really shown that this last week leading into the first conference game.”
Zip to the point:New-look for Akron men's soccer has team off to best start under coach Jared Embick
Sam Tojaga returns to Akron starting lineupTojaga has overcome injuries and made his first start Sunday since the spring 2021 season that took place after the fall 2020 season was canceled because of the COVID-19 pandemic
Tojaga missed all of the fall 2021 season due to a hip injury
“It meant a lot and was very exciting,” Tojaga said of being back in the starting 11
“I had a lot of nerves going through my head at the time because it was a very frustrating process with a lot of ups and downs
There were moments where I didn’t know if I would even be back out there again
so to be back on the field with the team and to especially win in this type of environment − everything came together and it was a great night.”
Embick was thrilled to watch Tojaga contribute in 59 minutes of playing time
“For a guy that started in the national final as a freshman [in 2018] and started a lot of games in 2019
“You could see a little bit of his quality [Sunday night] as he is coming back
He brings a lot of confidence and stability and just like him we have waited it out for so long
no one really knowing if we were going to get to this moment
“I went to him last week and said ‘It looks like in training you are ready
“Now we have to get to the point where we build up his minutes and get him used to playing 90
He is a big part of what we hope to accomplish.”
Victory in home opener:Josh Hallenberger, Dyson Clapier, Johnny Fitzgerald lead Akron to 3-1 soccer win over VCU
Clapier scored his goal Sunday in front of his parents
“They usually try to come once a year to see one game,” Clapier said
it is great to see the family and I am happy to get one with them in the stands.”
UA sophomore Malik Henry had an assist on Clapier’s goal with nifty a pass
Sangwa netted his goal in the 14th minute following a free kick by Zips sophomore Wan Kuzri Wan Kamal
Kamdem’s goal in the 19th minute came off of a deflection after Zips sophomore Jason Shokalook fired a shot off of the right post
Paulus contributed his goal in the 39th minute after receiving a pass from sophomore Josh Hallenberger
NIU’s goal came in the 89th minute after a UA defender accidently kicked the ball into the net
UA freshman goalkeeper Mitch Budler saved NIU’s lone shot on goal
“We came out with a lot of energy and intensity and I thought we were pretty sharp
I think once you get a big lead sometimes the sharpness goes
The goals didn’t follow in the second half
but up until the last minute we didn’t really give anything away
This was a good way to start the conference.”
a reserve midfielder and Highland High School graduate
was one of five players with local ties that played for the Zips on Sunday
The other four were junior starter Will Jackson (Hudson)
redshirt freshman reserve Sam Harter (Copley) and freshmen reserves Stefan Dobrijevic (Firestone) and Levi Stephens (Firestone)
● Akron’s next three matches are on the road at Bowling Green on Wednesday
The Zips next home match is against Bowling Green on Oct
Michael Beaven can be reached at mbeaven@thebeaconjournal.com
Follow Beaven on Twitter at www.twitter.com/MBeavenABJ
The University of Akron men's soccer team returned to "dominant soccer" in its 2021 season opening match Thursday night at FirstEnergy Stadium
UA scored four goals in the first half against visiting Wright State and added three more in the score half to record a 7-1 victory
Zips coach Jared Embick could not have scripted a better outcome as he watched his players dominate possession and dictate the tempo of the match against the Raiders
UA's current players resembled players from past teams under Embick and his predecessor, Caleb Porter
"I think you saw the potential of what we can do in the attack
we can just be ruthless at times and dominant
that is what we want to be and now we gotta regroup and show we can do it again
"We have got some guys that have some potential to open up the game
play and take people on and create and score goals
I think you saw that tonight and they are only going to get better."
Ryan Kingsford and Wan Kuzri Wan Kamal displayed that type of potential when they scored UA's first three goals
took on two guys and put the ball into the back of the net," said Clapier
Kingsford found the net in the 32nd minute and Wan Kamal scored off of an assist from freshman Jason Shokalook in the 35th minute
"I like having the ball in specific areas," said Kingsford
and it was a situation where it was a quick decision to think and a quick movement to shoot."
Zips sophomore Ivan Nikolic scored the final goal in the first half in the 42nd minute off of an assist from Wan Kamal
Clapier assisted on UA's first two goals in the second half when he connected with junior Renato Kauzlaric in the 52nd minute and Kingsford in the 65th minute.
Senior Diogo Pacheco netted UA's final goal in the 72nd minute off of a pass from Nikolic
"I am really happy with the team," Clapier said
"I thought we set the tone for the season."
UA freshman Malik Henry displayed speed and solid dribbling and passing in the midfield on several occasions
Zips senior goalkeeper Will Meyer made one save and allowed one goal
Embick trotted out a starting lineup that featured Meyer in goal; senior Daniel Strachan, junior William Portman, sophomore Will Jackson and freshman Jonas Buechte as defenders; Clapier, Henry
sophomore Johnny Fitzgerald and freshman Samu Siemens-Brega in the midfield and Kingsford and Kauzlaric up top at forward
The large lead allowed Embick to substitute regularly
"I think we can only build from this as coach said
but for us this is just a stepping stone and this is a start
We are going to build and we are going to keep getting stronger and stronger
and hopefully have more performances like this seven."
Big offensive night for ZipsUA's seven goals Thursday represents the second-highest goal total for the Zips in a season opener in program history
only surpassed by the 10 goals scored in a 10-0 victory over Cincinnati on Sept
UA's men's soccer team continues to attract players from all over the world
The Zips roster this year features players from the following countries: United States
Follow him on Twitter at www.twitter.com/MBeavenABJ
Redshirt senior Emil Jaaskelainen and the No. 13-ranked University of Akron men's soccer team (10-3-4
2-4-2) in a Big East Conference Tournament quarterfinal at 7 p.m
The Zips won the Big East Conference regular season championship and are led by Jaaskelainen
senior Malik Henry and redshirt Dyson Clapier
Jaaskelainen enters the match leading NCAA Division I men's soccer with 20 goals
This is Akron's second year in the Big East in men's soccer
Check back for updates on tonight's match between No
Emil Jaaskelainen scores two goals for the Zips and Victor Gaulmin nets one goal
Akron will meet Georgetown in a Big East Conference Tournament semifinal at 7:30 p.m
5 seed Creighton 1-0 in a quarterfinal Sturday
Akron men's soccer maintains lead over DePaul in Big East Conference Tournament quarterfinalAkron leads DePaul 3-1 with just under three minutes remaining in the second half
Akron has five shots on goal and six corner kicks
DePaul has one shot on goal and one corner kick
Akron leads DePaul 3-1 with just under 15 minutes remaining in the second half
DePaul has one shot on goal and no corner kicks
DePaul men's soccer trims Akron's lead in Big East Conference Tournament quarterfinalDePaul's Logan Finnegan scores a goal with 26:04 to go in the second half
Akron's Emil Jaaskelainen and Malik Henry with shots on goal that are either kicked or batted away
Akron leads 3-0 with just under 38 minutes remaining in the second half
Akron's Emil Jaaskelainen scores another goal with another header with 43:34 to go in the second half and the Zips lead 3-0
The Zips have two shots on goal and both went into the net
Akron has one corner kick and DePaul has none
Akron's Emil Jaaskelainen scores a goal with a header with 15:39 to go in the first half
Beto Ydrach started the scoring sequence with a kick off of DePaul defenders and Jaaskelainen redirected the ball into the net for his 21st goal this season
Akron's Victor Gaulmin scores a goal off of a pass from Malik Henry
The Zips lead 1-0 with 18:59 remaining in the first half
Akron men's soccer awarded a corner kickAkron's Victor Gaulmin sent in a corner kick with 27:32 remaining in the first half and it did not lead to a goal
Akron 12th-year head coach Jared Embick is starting the following 11 players: redshirt junior goalkeeper Mitch Budler
redshirt senior forward/midfielder Dyson Clapier
senior forward/midfielder Malik Henry and redshirt senior forward Emil Jaaskelainen
Freshmen Jack Roman and Nicholas Beier and juniors Stefan Dobrijevic and Daragh Reilly are key reserves
has 20 goals and seven assists in his first season at Akron after being a two-time NEC Player of the Year during four seasons at Long Island
Akron's Dyson Clapier has four goals and eight assists
Victor Gaulmin has three goals and eight assists
senior Wan Kuzri Wan Kamal has four goals and five assists and Stefan Dobrijevic has two goals and four assists
Dobrijevic is a Firestone High School graduate
Sophomore midfielder Noeh Hernandez leads DePaul with eight goals and nine assists
Graduate forward Logan Finnegan is second on DePaul's squad in goals with six
Senior Santiago Davila is DePaul's goalkeeper and Mark Plotkin is in his seventh season as the head coach at his alma mater
Akron and DePaul meet for the third time in men's soccer on Saturday
The Zips have a 2-0 edge in the series with a 4-0 victory in Chicago on October 19 and a 3-0 win last season at FirstEnergy Stadium in Akron
Michael Beaven can be reached by email at mbeaven@thebeaconjournal.com
With just four games left in the regular season
the University of Akron men’s soccer team is having a bit of an identity crisis
It’s not that the Zips don’t know how to win
it’s just that they haven’t done it very consistently this season
That unpredictability reared its head again Monday in a 0-0 double-overtime tie with Michigan
“I don’t think it was the prettiest game to watch or to play in,” Zips coach Jared Embick said
“Michigan came in and did what they did
but I don’t think our energy level was nearly what it needs to be in these games to claim a victory
“When you get into situations where every result matters you can play not to lose games
teams we’ll play are very similar to Michigan.”
24 Akron (7-3-3) needs to figure out with Mid-American Conference games against Bowling Green
Northern Illinois and Western Michigan and a nonleague matchup against Cleveland State remaining
“It’s more maturity and probably a little bit of confidence,” Embick said
“You can see us against some of the best teams
and in the biggest games we’re very intense
Then there’s some games where we don’t have the same intensity and energy
you have to have that or your style of play just doesn’t come out
I think that’s where we’re just a little immature
We have to find ways to have back-to-back good performances and intensity
That’s been frustrating for coaches and the team.”
That was especially true against the Wolverines (6-5-3)
who took everything Akron threw at them and turned it away
“It has to be a constant desire and will to win,” Zips defender Daniel Strachan said
“It’s getting to the end of the year and there’s not much time left
maybe a result like this you can just move on and build from it
We have to have put in the effort and make sure we’re communicating
being accountable and being all the things that it takes to be a great team
If there is a silver lining it’s that Michigan gave Akron a game it might see in the conference playoffs and NCAA Tournament
The Wolverines took one less shot (11) than the Zips
but put three on frame to Akron’s two
The best attempt came from the Zips in the first overtime when forward Dyson Clapier crashed in from the right side
Although it was an unfortunate result for Akron
the good news is it won’t have long to sit on the tie with Bowling Green coming to town on Friday
“Not every shot is going to come off easy,” Clapier said
“You’re going to have to work for it sometimes
they don’t give anything away for free
You have to work hard and get the shots off the best you can
“It’s starting to become crunch time
The team is frustrated with the home performances
but you can still turn it around the next four games.”
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AKRON, Ohio – The University of Akron men’s soccer squad under the leadership of eighth-year head coach Jared Embick
has announced a talented 10-member newcomer class that will hit the pitch for the Zips during the Spring 2021 campaign
A midfielder from Layton, Utah, Clapier gained valuable playing experience with the Portland Timbers Academy and Portland Timbers 2 in the USL
He made his USL debut with the Timbers 2 at the age of 17 and scored his first goal for the squad at the age of 18
Embick on Clapier – “Dyson is a talented winger
and is a threat to score and create in the final third
He has great attacking instincts and competitive spirit.”
A goalkeeper from Decatur, Ga., Hangi gained valuable playing experience with the Atlanta United Development Academy
TopDrawerSoccer.com ranks him 31st in the South Atlantic Region
Embick on Hangi – “Josh is an athletic keeper with great potential
We see him as a player that has great talent
Those attributes will help him develop into an outstanding keeper.”
Embick on Harter – “He is a very well-rounded player
I think he is further along in his development at this age than his brother Skye
He is versatile and can play multiple positions
but we see him as a midfielder that can help us control games on both sides of the ball.”
A native of Irmo, S.C., Jones, a versatile center back has gained valuable playing experience with South Carolina United
where a year ago he earned Elite Clubs National League all-conference honors as well as an invitation to the ECNL after helping his squad to conference and regional titles
he also played for the SC United Bantams in the United Soccer League Two
he earned All-State and All-Regional accolades as a junior at Dutch Fork High School
He was also rated 24th in the South Atlantic Region by TopDrawerSoccer.com
Embick on Jones – “We really like Paul’s ability to play out of the back and initiate our build-up play
He is a very smart player and has the toughness to be a very good player for us
He is just a player that fits our style and identity
Embick on Metsack – “Nate is an athletic defender
who can use his toughness and athleticism in the game to put out a lot of fires
He will allow us to play a high line in the back
His ability is a great compliment to our other defenders.”
Meyer joins the Zips after playing his initial three campaigns at Louisville
where he appeared in 15 career matches for the Cardinals
nine shutouts and a 0.77 goals against average
he started and made three saves in net en route to earning a shutout in a 0-0 double-overtime draw with Akron in the Elite Eight
a contest which the Zips advanced to the College Cup on penalty kicks
He posted a 0.37 goal against average in three NCAA Tournament games in 2017
including garnering shutouts versus Colgate and Akron
including 56 matches overall and was named first-team All-Ohio
Conference Player of the Year and First-Team All-Conference as a senior
Embick on Meyer – “We are excited that we were able to convince Will to come back and finish his last year in our program
He is a very smart and athletic keeper that has the ability to steal games for you from the keeper position
I think he has potential to be one of the best keepers in college this year.”
A native of Fairview, Pa., Scott, a winger/right back has gained valuable playing experience with the Internationals Academy in the United States Development Academy, where he led his squad in scoring as a freshman with 16 goals. He also helped lead his Columbus Crew SC Academy U17 and U19 teams to the playoffs as a sophomore and junior
as well as the knockout stage of the Development Academy Playoffs in 2018
Embick on Scott – “Nick is a tremendous athlete
who brings speed and toughness and can really open up the game on the wing
He is an aggressive player and can run all day
He can play as a fullback or winger and is a player that is only going to get better and better in our program.”
A native of Erie, Pa., Shokalook, a versatile forward has gained valuable playing experience with the Internationals Academy in the United States Development Academy
TopDrawerSoccer.com ranked him as the 12th-best forward in the Class of 2020 as well as sitting 48th overall in the IMG Academy 150
He was named to the Academy Select team and garnered an invitation to the U.S
Embick on Shokalook – “A big-time goal scorer
Jason has a chance to become a special player
Every year he has played he has been one of the best goal scorers in the country in his age group”
He returned to the Union Academy to finish high school where he was a 2018 United Soccer Coaches Youth Boys All-East Region Team selection and was rated by TopDrawerSoccer.com as a four-star forward and the No
17 forward in the nation as well as ranking No
Temple scored seven goals in 12 appearances with the Philadelphia Union U-18/19 squad during the 2018-19 season
while finishing second on the Union’s U-18/19s with 20 goals during the 2017-18 campaign
Embick on Temple – “Tonny is transferring to us after a year at NC state
We tried to get him coming out of high school and are excited he is coming to us now
he is another player that is dangerous every time he has the ball in the final third
He can open up the game for us and makes our attack even more dangerous.”
A native of Columbia, S.C., Williams, a versatile forward/winger has gained valuable playing experience with the South Carolina United
where he helped his squad to conference and regional titles a year ago
skill and determination is best way to describe Damon
but we feel he can develop into an impact player in the future
He is a player to watch for us as he can play as a forward or an outside back.”
Tasker Wheeler heads to Marquette University
Western Michigan men's soccer signed 5 recruits
Michigan State signed four men's soccer recruits
The Indiana Hoosiers added seven new recruits
Notre Dame unveiled its 2021 signing class
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University of Akron men's soccer coach Jared Embick wore a T-shirt under his jacket Wednesday with the word 'RELENTESS' across his chest
His players got the message with a spirited effort in a 2-1 victory over visiting Penn State at FirstEnergy Stadium
The win came after UA lost 3-1 at home to Georgia State on Saturday
"We have been talking about sticking with the process
waking up and being focused on the next game and our goals," Embick said
"You can't let setbacks affect you and I think tonight was a great example of 'Hey
"I think everybody thinks you are just going to play well and carry it on for two or three months
but with this schedule we have a lot of challenges and different games to prepare us
but we gotta stay focused on what we can do."
Embick said he ordered the T-Shirt from "our old friends at Amazon."
Sophomore Ryan Kingsford and freshman Dyson Clapier scored goals in the first half to give the Zips a 2-0 lead at halftime
Senior Dax Hoffman netted a goal in the second half for the Nittany Lions (8-4-1) to make things interesting with eight minutes to go
but the Zips (7-3-2) regrouped and held on for the win
"I thought in the first half we were awesome," Embick said
"We were all over them and played really well
I know that we were frustrated after the last game and we had a great opportunity
Penn State is undefeated in the Big Ten and they are ranked
For us to play like that after a frustrating game shows that we have a lot left and we are still committed to reaching our goals."
shots on goal (5-3) and corner kicks (8-6)
Zips senior goalkeeper Will Meyer made two saves and Nittany Lions junior goalkeeper Kris Shakes had three saves
Kingsford's goal came in the 16th minute with freshman Malik Henry and sophomore Johnny Fitzgerald each getting an assist
"We have had ups and downs for the past few games," Kingsford said
I put so much pressure on myself and they have taken that off of me
... This is such a relief off my shoulders."
Clapier made it 2-0 with his goal in the 20th minute following passes from senior Diogo Pacheco and Kingsford
"I remember the ball going to Diogo and I heard Kingsford in the back of my ear telling me to spread to the box
I just made my run and buried the ball into the back of the net."
Hoffman's strike in the 83rd minute came off of a pass by senior Seth Kuhn
"I liked our commitment to what our game-plan was because we knew if we weren't Penn State was going to be a team that could expose us," Embick said
"We needed to be committed and we needed to move on from last game
when we are fully committed every side of the ball for 90 minutes
Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell
Genes are tightly packaged when they are not activated and then unpackaged by chromatin remodeling machines when genes need to be turned on
Mutations in chromatin regulating machines are a significant driver of cancer and other human diseases
as the mutant chromatin regulators improperly unpackage and express genes
Chromatin remodeling machines have been a longstanding focus of Brad Cairns, PhD, study lead author, who discovered the first chromatin remodeling machine in 1996. Cairns is a scientist at Huntsman Cancer Institute (HCI) and professor and chair of oncological sciences at the University of Utah (U of U)
The Cairns Lab works to understand how chromatin impacts gene expression in humans and other organisms and provides instructions for cell growth
An important aspect of this work is better understanding the role of chromatin in cancer and other diseases
The major component of chromatin is nucleosomes
which are similar to beads upon which DNA is wrapped like a string
explaining why chromosomes look like beads on a string under a powerful microscope
Cairns and colleagues wanted to know how these beads are moved along or removed from the DNA to unpackage and expose genes
Previous work showed that chromatin remodeling machines have a motor-like component that drives the machine along the DNA
The fuel for the cellular motor is called ATP
the motor ensures that the right genes are properly unpackaged
the wrong genes are unpackaged—and cancer or improper development results
Cairns’s team wanted to understand how the motor of the machine is regulated
"These really are machines: they contain a ‘gas pedal’ and a ‘clutch’ that together control whether and how the motor moves the machine along the DNA
This new paper shows the gas pedal and clutch sit right on the motor
and the cancer-causing mutations localize to the clutch and gas pedal itself
making the motor hyperactive and unpackaging genes when it should not." The work reveals how factors in the cell can activate the machine to do its work at the right place and time
Cairns and his colleagues used data on mutations in human tumors from the COSMIC cancer database
the largest cancer genomics database in the world
in order to study the human chromatin remodeling machine called BAF/PBAF
BAF/PBAF is mutated in 20% of all human tumors
They studied these human mutations using yeast as a model system
This analysis revealed a structural hub that tells the motor when to engage (the clutch) and how fast to run along the DNA (the gas pedal)
the team found a series of cancer mutations in an area of the hub that regulates the motor activity and thus ensures proper movement or removal of nucleosomes and proper gene expression
These mutations in the regulatory hub of the motor created a hyperactive and dysregulated motor that improperly opens up chromatin
The team’s findings shed light on a key regulatory behavior of healthy cells and explain how a set of cancer-causing mutations promote cancer
Cedric Clapier, PhD
a member of the Cairns Lab and research associate professor of oncological sciences
This research was supported by the National Cancer Institute grants P30 CA042014
Fax number: 801-213-6048All clinical services and programs are part of University of Utah Health Hospitals and Clinics
Copyright © 2025 University of Utah Health
A stand of aspen trees along the popular Mid-Mountain trail near Deer Valley is experiencing extensive die-off
Keith Clapier is a master arborist and was contracted to prepare a report about the area earlier this year
The popular Mid-Mountain hiking and biking trail crosses Guardsman Pass Road above the new project
Clapier explained that the aspen stand has been isolated on three sides by the Guardsman Pass and Twisted Branch roads for many years
The process began decades ago when Guardsman Pass Road was constructed and later paved
His report indicates the Mid-Mountain trail has caused no impact on the trees in the area
Clapier said years of development in the area contributed to these aspen trees being isolated from their broader root system
“So now it's completely fragmented," Clapier said
"That's probably what was giving its life support because I think this column is part of that column on the other side
It went all the way up to halfway up Hawkeye
It’ll progressively get worse over time unless mitigated.”
Clapier’s report identifies 276 aspens that should be removed
with the bark easily peeling off and exposing the infection underneath
Most are suffering from what’s called sooty bark canker fungus
which quickly grows vertically up the tree
Clapier said the fungus will eventually wrap
they could fall during high winds and create hazards to people and property
Clapier said the most significant impact is on the wildlife that doesn’t like entering areas surrounded by hard surfaces
He said the area could recover if specific steps are taken
“If they are going to be running skid steers and cement mixers and whatever in here
they could protect the existing root system by buffering it with mulch and old sheet plywood," Clapier said
you flush cut it [leaving stumps] and then just try to protect the root.”
Aspen trees are connected in vast underground root systems
Clapier said that when hiking or riding through an aspen forest
He referred to the aspen forest in the Fish Lake area in central Utah
“It’s the oldest in the world and it’s the largest organism on Earth
I think it's somewhere around 1,000 acres or something
this is roughly about 10 acres approximately
That seems to be about the average size of a clone in the Wasatch Mountains
but they can be anywhere from 1 to 10 acres in size.”
Clapier recommended that 276 dead aspens be cut and removed from the site
He said stumps should remain because they can stimulate growth and help remove the cells of the sooty fungus
He suggests installing fencing around the living aspens and irrigating the land during the hottest
driest months to alleviate stress from drought
He also proposes that builders use designated construction routes to minimize hard-packing dirt and severing roots
Clapier believes that if those recommendations are followed
the root and remaining aspens could be preserved
The Park City Planning Commission considered the findings in the March 9 meeting
Montpellier Mediterranee Metropole and TaM
Montpellier Tramway Line 5 is the fifth line of the tram network operating in Montpellier
It is the first development since the completion of Line 4 in 2012
The 16km line is being developed by Montpellier Mediterranee Metropole (MMM)
MMM has appointed Transports de l’agglomeration de Montpellier (TaM)
Montpellier Tramway Line 5 development is part of MMM’s mobility plan aimed at improving the city’s overall transportation system and reducing mobility-related carbon emissions by expanding the tram and bus network
Construction works on the project were initiated in 2019 and are expected to be completed in the second half (H2) of 2025
Line 5 will provide sustainable mobility for 80,000 passengers a day with trams operating at a frequency of one in six minutes
The project will create 11,000 direct and indirect jobs
it will improve the transit between research facilities including Campus Agropolis
Centre national de la recherche scientifique
and the National Institute of Health and Medical Research
The new line will also offer an efficient alternative to car use and support new urban densification
The Montpellier Tramway Line 5 will extend from Clapiers to Laverune to form a north/south-west diagonal complimenting the existing four lines of the tramway that form a star
The north-south line will extend from Saint-Eloi to Clapiers while the south-west route will run from Saint-Denis to Laverune
Line 5 will share 3km of its length with lines 1
Apart from enabling the creation of new green spaces
Line 5 will connect ten existing green spaces within Montpellier including Parc Montcalm
The new line will be accessible by bicycle with cycling paths and a pedestrian crossing being created
Montpellier Tramway Line 5 connects Clapiers and Laverune passing through the communities of Prades-le-Lez
and Montpellier offering high-quality connectivity to metropolitan France’s activity centres
The route will include 27 strategic stations in research and university centres
The project includes three significant phases of construction
ensuring future renovations do not impact traffic on the line
preparatory work began in the northern section of the line and will continue in the west
allowing for diversion from current networks
focuses on infrastructural improvements such as building new roads
The final phase will focus on train tests and dry runs
Montpellier Tramway Line 5 will be served by 22 CAF Urbos 100X bidirectional trams
The CAF Urbos 100X line features seven module units with low floors for easy entry
The trains will be 43.2m long and have a capacity of 304 passengers
The trams will prioritise passenger comfort and safety
with specially designed seats for urban transportation systems
MMM is contributing €346m towards the development of Line 5
The remaining €94m is being funded by the Ministere de l’Economie
Finance and Industrial and Digital Sovereignty
and Atelier Garcia-Diaz was awarded the project management contract for the new line
and project management group and is providing design services and works supervision as part of the consortium
SYSTRA is an engineering and consulting group based in France and is providing engineering and project management services
Construcciones y Auxiliar de Ferrocarriles, a rolling stock manufacturer, was awarded a €225m contract to supply rolling stock for the project in June 2022
The contract includes the supply of 60 trams
with an option to add 17 more trams in the future
and eight to boost reserves during maintenance activities
A consortium led by Eurovia and Sogea Environnement was awarded a €32.5m contract in June 2023 to undertake infrastructure works for Line 5
Eurovia and Sogea Environnement are both subsidiaries of VINCI Construction
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SALT LAKE CITY (KUTV) — Make-A-Wish Utah granted a unique gift for a six-year-old girl. They partnered with Ballet West to allow Evelyn Svete to live out her dream of performing as Clara in “The Nutcracker.”
“I love being in the Nutcracker!,” said Evelyn after her matinee performance with Ballet West
She got the idea of performing as Clara while in the hospital last year
Svete was diagnosed with cancer the week before Christmas 2020
She saw Ballet West's Nutcracker on TV
watching it on Christmas Eve and again on Christmas day
hoping someday she could play the iconic role of Clara
Eliza Clapier, a wish coordinator with Make-A-Wish Utah
"Wishes give kiddos and their families the courage and strength to fight these illnesses,” said Clapier
On show day her parents Margo and Kyle watched with tissues in hand
"It felt really awesome to just revel in it
To sit back totally watch her do her thing,” said Margo Svete
Gliding gracefully across the stage and smiling as the price twirled her around
"I was feeling excited and happy,” she said
which makes sense as she has overcome even scarier situations
her mom said she got really sick and lost a lot of weight
the ballerina on stage is sparkling and strong
it felt like there's a lot of joy that came with it
and it helped with some of that relief of we've made it through step one at least,” said Kyle Svete
I want to be the sugar plum fairy,” she said
Metrics details
The dynamic regulation of chromatin involves four subfamilies of ATP-dependent nucleosome-remodelling complexes: imitation switch (ISWI)
switch/sucrose non-fermentable (SWI/SNF) and INO80
Each subfamily is specialized to preferentially achieve particular chromatin outcomes: assembly
Diversity in the protein composition of remodellers enables their specific interaction with particular transcription activators
all remodellers have a similar ATPase 'motor' that translocates DNA from a common location within the nucleosome
The diverse specialized proteins and domains in each remodeller subfamily are also involved in detecting nucleosome epitopes
which differentially regulate the conserved ATPase–translocase motor to achieve the various chromatin-remodelling outcomes
We propose an 'hourglass' model of chromatin remodelling that involves convergence on a DNA translocation mechanism
which is preceded and followed by remodeller diversity
in terms of differential remodeller targeting and remodelling outcomes
Remodellers are emerging as 'smart' machines that are informed about whether or how to utilize DNA translocation to conduct chromatin remodelling
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding
ejection or the incorporation of histone variants
suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies
all chromatin-remodelling complex subfamilies contain an ATPase–translocase 'motor' that translocates DNA from a common location within the nucleosome
we discuss (and illustrate with animations) an alternative
unifying mechanism of chromatin remodelling
which is based on the regulation of DNA translocation
We propose the 'hourglass' model of remodeller function
in which each remodeller subfamily utilizes diverse specialized proteins and protein domains to assist in nucleosome targeting or to differentially detect nucleosome epitopes
These modules converge to regulate a common DNA translocation mechanism
to inform the conserved ATPase 'motor' on whether and how to apply DNA translocation
which together achieve the various outcomes of chromatin remodelling: nucleosome assembly
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Cancer biology and NuRD: a multifaceted chromatin remodelling complex
The biology of chromatin remodeling complexes
Regulating the chromatin landscape: structural and mechanistic perspectives
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
ATP-dependent chromatin remodeling: genetics
Becker, P. B. & Workman, J. L. Nucleosome remodeling and epigenetics. Cold Spring Harb. Perspect. Biol. http://dx.doi.org/10.1101/cshperspect.a017905 (2013)
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs
Histone chaperones: assisting histone traffic and nucleosome dynamics
Identification of a rapidly formed nonnucleosomal histone-DNA intermediate that is converted into chromatin by ACF
a stable conformational isomer of the nucleosome
ISWI is an ATP-dependent nucleosome remodeling factor
Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II
Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly
an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor
Removal of promoter nucleosomes by disassembly rather than sliding in vivo
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex
This study demonstrated for the first time that SWR1C carries out nucleosome editing that involves H2A.Z
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A
Distinct factors control histone variant H3.3 localization at specific genomic regions
Direct observation of DNA distortion by the RSC complex
DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size
Stepwise nucleosome translocation by RSC remodeling complexes
Dynamics of nucleosome remodelling by individual ACF complexes
References 23–26 investigate the size of the DNA step that occurs during DNA translocation by SWI/SNF remodellers
ISWI induces nucleosome sliding on nicked DNA
Chromatin remodeling by RSC involves ATP-dependent DNA translocation
Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme
References 28 and 29 demonstrated for the first time that chromatin remodellers act by DNA translocation
Functional role of extranucleosomal DNA and the entry site of the nucleosome in chromatin remodeling by ISW2
A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling
Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes
This work demonstrates that the ISWI ATPase is an intrinsically active DNA translocase that is regulated by 'inhibition of inhibition' of both ATPase activity and coupling
H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast
This work demonstrates that SWR1C interacts with nucleosomes at position SHL2 and that histone exchange requires DNA translocation
Regulation of DNA translocation efficiency within the chromatin remodeler RSC/Sth1 potentiates nucleosome sliding and ejection
This study shows that nucleosome ejection by the Sth1 ATPase is achieved through the upregulation of DNA translocation efficiency
and that actin-related proteins are required by the remodeller RSC for nucleosome ejection
ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF
Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer
References 36 and 37 reveal the capacity of ISWI subfamily remodellers to perform nucleosome sliding
Nucleosome mobilization catalysed by the yeast SWI/SNF complex
This work showed for the first time that SWI/SNF subfamily remodellers carry out nucleosome sliding
SWI/SNF chromatin remodeling requires changes in DNA topology
Dynamics of ATP-dependent chromatin assembly by ACF
Reaction cycle of the yeast Isw2 chromatin remodeling complex
Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling
Spatial contacts and nucleosome step movements induced by the NURF chromatin remodeling complex
References 43 and 44 define the binding of the ISWI subfamily remodellers to extranucleosomal DNA
and within the nucleosome two DNA helical turns from the dyad
Chromatin remodelling: the industrial revolution of DNA around histones
The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing
Structure and mechanism of helicases and nucleic acid translocases
The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor
Structure of chromatin remodeler Swi2/Snf2 in the resting state
Structure and regulation of the chromatin remodeller ISWI
References 48–50 present the crystal structures of the Chd1
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism
Chromatin remodeling through directional DNA translocation from an internal nucleosomal site
Histone octamer transfer by a chromatin-remodeling complex
This was the first report of nucleosome ejection by SWI/SNF remodellers
Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome
References 53 and 55 demonstrate that DNA translocation occurs within the nucleosome
The SnAC domain of SWI/SNF is a histone anchor required for remodeling
The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor
Extranucleosomal DNA binding directs nucleosome sliding by Chd1
No need for a power stroke in ISWI-mediated nucleosome sliding
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA
ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor
GAL4 directs nucleosome sliding induced by NURF
The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome
The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription factors
Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI
Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF
A critical epitope for substrate recognition by the nucleosome remodeling ATPase ISWI
References 65–67 report the discovery and characterization of the activation of the ISWI remodeller by the histone H4 tail basic patch
Two distinct mechanisms of chromatin interaction by the Isw2 chromatin remodeling complex in vivo
Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA
The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes
A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler
Structural analysis of the RSC chromatin-remodeling complex
Structural analysis of the yeast SWI/SNF chromatin remodeling complex
Structural studies of the human PBAF chromatin-remodeling complex
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method
Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex
Structure of a RSC-nucleosome complex and insights into chromatin remodeling
Architecture of the SWI/SNF-nucleosome complex
Site-specific attachment of reporter compounds to recombinant histones
Chromatin remodeling by nucleosome disassembly in vitro
Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement
The ATP-dependent remodeler RSC transfers histone dimers and octamers through the rapid formation of an unstable encounter intermediate
Chromatin remodeling: insights and intrigue from single-molecule studies
Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription
Nucleosomes can invade DNA territories occupied by their neighbors
SWI/SNF has intrinsic nucleosome disassembly activity that is dependent on adjacent nucleosomes
Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity
This study demonstrates nucleosome editing by the remodeller INO80C and that INO80C prevents the mislocalization of H2A.Z outside of gene promoters
Involvement of actin-related proteins in ATP-dependent chromatin remodeling
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme
Chromatin dynamics and the RNA exosome function in concert to regulate transcriptional homeostasis
a histone H2A variant that poises repressed/basal promoters for activation through histone loss
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin
Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange
The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer
Stepwise histone replacement by SWR1 requires dual activation with histone H2A
This study describes the stepwise replacement of H2A with H2A.Z in nucleosomes by the remodeller SWR1C
Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1
Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex
Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C
References 99–101 present the latest structures of the remodellers INO80C and SWR1C
The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling
Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex
Assembly of the Arp5 (actin-related protein) subunit involved in distinct INO80 chromatin remodeling activities
Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex
Signals and combinatorial functions of histone modifications
Chromatin remodeling: a marriage between two families
SWI/SNF binding to the HO promoter requires histone acetylation and stimulates TATA-binding protein recruitment
Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Structural basis of histone H4 recognition by p55
Double chromodomains cooperate to recognize the methylated histone H3 tail
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC
Chromatin remodeling enzymes: taming the machines: third in review series on chromatin dynamics
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms
A cooperative activation loop among SWI/SNF
gamma-H2AX and H3 acetylation for DNA double-strand break repair
SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases
Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2
Swi/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions
Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation
NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex
Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z
This work was the first to show a regulatory role for H2A.Z in nucleosome remodelling by ISWI
Modulation of ISWI function by site-specific histone acetylation
This work was the first to demonstrate that chromatin remodellers can be regulated by a histone modification
Histone H4-K16 acetylation controls chromatin structure and protein interactions
ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
DNA looping facilitates targeting of a chromatin remodeling enzyme
Remodeling the chromatin structure of a nucleosome array by transcription factor-targeted trans-displacement of histones
Activation domains drive nucleosome eviction by SWI/SNF
Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators
References 139–141 present initial evidence that transcription activators can regulate chromatin remodelling
Dynamic regulation of transcription factors by nucleosome remodeling
UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression
Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif
Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF- INK4a locus
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
chromatin structure and the regulation of transcription
Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly
The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism
The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo
The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus
The ISWI chromatin remodeler organizes the hsromega ncRNA-containing omega speckle nuclear compartments
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
A long noncoding RNA protects the heart from pathological hypertrophy
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
Chromatin regulatory mechanisms in pluripotency
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner
A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage
ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor
chromosome organization and DNA replication
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI
The SANT domain: a unique histone-tail-binding module
Domain architecture of the catalytic subunit in the ISW2-nucleosome complex
Yeast Isw1p forms two separable complexes in vivo
Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions
TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila
The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor
Novel Mi-2 related ATP-dependent chromatin remodelers
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains
The human Mi-2/NuRD complex and gene regulation
CHD chromatin remodelers and the transcription cycle
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo
Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes
Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler
This work presented the first structure of an ARP module bound to a remodeller HSA domain
Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes
SnapShot: chromatin remodeling: INO80 and SWR1
RVB1/RVB2: running rings around molecular biology
Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants
Crystal structure of a nuclear actin ternary complex
EP400 deposits H3.3 into promoters and enhancers during gene activation
Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks
YY1 functions with INO80 to activate transcription
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair
Crystal structure of the nucleosome core particle at 2.8 A resolution
Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution
Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler
Mechanism of chromatin remodeling revealed by the Snf2−nucleosome structure
Concerted regulation of ISWI by an autoinhibitory domain and the H4 tail N-terminal tail
Interdomain communication of the Chd1 chromatin remodeler across the DNA gyres of the nucleosome
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This work was supported by the Howard Hughes Medical Institute (HHMI) (C.R.C
the US National Institutes of Health (NIH) (GM60415 to B.R.C.; GM054096 and GM049650 to C.L.P.)
Howard Hughes Medical Institute and Department of Oncological Sciences
University of Massachusetts Medical School
The authors declare no competing financial interests
The composition of each subfamily of chromatin remodellers in Saccharomyces cerevisiae
Monomeric DNA helicases and chromatin remodellers share a common mode of translocation
involving a protein motor core formed by two RecA-like lobes (shown in light and dark orange) which bind the same strand of DNA with one lobe slightly ahead of the other
These lobes sequentially bind and release DNA
enabling an 'inchworming' mechanism of unidirectional movement in the 3′ to 5′ direction along the tracking strand
In order to perceive how this property is applied to the nucleosome
we change perspective and hold the translocating enzyme in a fixed position
The DNA then appears to be pumped by the enzyme
and undergoes rotation during translocation
We now depict the RecA-like lobes as mittens that reciprocally move
The physical step size of 1 base pair per ATP hydrolysis depicted here is based on crystal structures and biophysical measurements of translocation (which are 1 to 2 bp) by chromatin remodelling ATPases and related helicases and translocases
This animation starts by depicting both the protein and DNA components of the nucleosome
which is the fundamental unit of chromatin structure in eukaryotes
The eight histone proteins are shown in green
The canonical nucleosome core particle consists of 147 base pairs of DNA wrapped in 1.67 left-handed superhelical turns around a histone octamer
though in this depiction the DNA is extended
The nucleosome has a two-fold rotational symmetry along a feature called the dyad axis
the thirteen histone-DNA contacts can be visualized (flashing white
and then staying blue) to form a positively-charged staircase along the surface of the octamer
upon which the negatively-charged DNA is wrapped
and subsequently disassembled into the central H3-H4 tetramer (light green proteins) capped on each end by an H2A-H2B dimer (darker green proteins)
the staircase of histone-DNA contacts is again revisited
and the DNA re-wrapped along that staircase to form the nucleosome
Here we depict how chromatin remodellers can conduct nucleosome sliding via monotonous DNA translocation
and depict the DNA much shorter on one side
to help illustrate subsequent DNA movement and extension
this canonical nucleosome is bound and fully enveloped by RSC
which has a large pocket of nearly perfect nucleosome dimensions
the two orange RecA-like lobes bind to the DNA at a fixed position within the nucleosome
the lobes perform directional DNA translocation by pulling in DNA from the proximal side of the nucleosome and pumping it toward the distal side
the lobes function like DNA-grabbing mittens
which undergo a cycle of inchworming along the DNA backbone
sequentially grabbing and releasing the DNA
translocating one base pair of DNA per ATP hydrolysis
in which the DNA at the entry site moves in concert with DNA at the exit site
A more sophisticated depiction involving sequential movement
first on the distal size and then on the proximal side
Here we depict how chromatin remodellers can conduct nucleosome sliding via sequential (or discontinuous) DNA translocation
bind to nucleosomal DNA at a fixed position
two helical turns from the dyad axis and perform directional DNA translocation by pulling in DNA from the proximal side of the nucleosome and pumping it toward the distal side
Translocation creates DNA torsion and translational tension on both sides of the mittens – which in this animation
in two sequential steps – as has been shown in the remodeller ISWI
the extra DNA can propagate in a wave-like manner toward the distal exit side of the nucleosome by diffusion
breaking histone-DNA contacts as it propagates (depicted by flashing lights)
translocation also breaks histone-DNA contacts (also depicted as flashing lights)
drawing DNA from the proximal linker into the nucleosome
The result is histone octamer displacement
generically referred to as nucleosome sliding
We depict here the ISWI ATPase bound to a fragment of the Acf1 protein in an unfolded state
The ISWI remodeller contains two RecA-like lobes
which comprise the DNA translocating motor
as well as three remarkable regulatory domains: AutoN
and are therefore depicted in red under conditions where they inhibit ISWI
for example in the folded structure in the absence of the nucleosome
The order of domain interaction with the nucleosome is not known
but for depiction here we display the initial binding of ISWI RecA-like lobes to the nucleosome
followed by the binding of the HSS domain to the linker DNA on the proximal side
The presence of the H4 tail (in light green) releases AutoN inhibition (notice the color change) via a competition mechanism
the release of the NegC inhibition (also note the color change) and restoration of coupling
occurs via change of conformation due to HSS binding the DNA
Once released from its intrinsic inhibitions
the RecA-like lobes perform DNA translocation
this tension is resolved by DNA wave propagation
the tension is constrained between the lobes and the HSS domain which is resolved by the HSS releasing from the linker DNA
allowing DNA to be drawn into the nucleosome before rebinding
This cycle results in the displacement of the histone octamer relative to the DNA
Iterations of this cycle draw the adjacent nucleosome closer and closer
until the adjacent nucleosome interferes with the binding of the HSS domain by steric hindrance
When the HSS can no longer rebind linker DNA
ISWI changes to a conformation in which HSS fails to antagonize the NegC domain and the H4 tail stops competing with AutoN
resulting in the cessation of DNA translocation and the release of ISWI from the nucleosome
the HSS functions as a 'molecular ruler' leaving the adjacent nucleosome at a fixed distance from the substrate nucleosome (termed nucleosome spacing)
Sequential application of this mechanism by one or more ISWI/ACF complexes (as depicted) occurring on all nucleosomes on the template produces an array that results in all the nucleosomes being the same distance apart
Actin and actin-related proteins (PDF 149 kb)
In addition to the RecA-like lobes which comprise the DNA translocating motor
the SWI/SNF remodeller ATPase subunit contains an HSA domain
which binds a heterodimer of the Actin-Related Proteins
The HSA region folds back and interacts with one of the RecA-like lobes
The SWI/SNF motor subunit binds to the nucleosome two helical turns from the dyad and performs DNA translocation through an inchworming mechanism
drawing in DNA from the proximal linker and pumping it towards the distal linker
the flashing lights depict the breakage and reformation of histone-DNA contacts
This results in the displacement of the histone octamer relative to the DNA
Binding of the Actin-Related Proteins to the HSA domain greatly improves the efficiency of DNA translocation
Efficient and forceful DNA translocation result in the rupture of several histone-DNA contacts
Beyond the RecA-like lobes (shown in orange)
the SWR1C histone exchanger motor subunit (termed Swr1) contains an HSA domain which binds the Arp4 and Actin heterodimer
as well as a N-terminal domain for interaction with an H2A.Z variant-H2B dimer
Swr1 binds two helical turns from the dyad
and its N-terminus interacts with an H2A.Z variant-H2B dimer (shown in yellow-dark green)
which stimulates Swr1 ATPase activity and DNA translocation
The SWR1C exchanger apparently does not allow translocated DNA to pass to the distal side of the nucleosome
perhaps due to the presence of a domain or protein that prevents additional DNA movement (shown in dark blue)
only the histone-DNA contacts located on the proximal side of the nucleosome are destabilized
promoting the removal of a canonical H2A-H2B dimer and the loading of the H2A.Z variant-H2B dimer
Histone-DNA contacts are then restored by the DNA wrapping onto the newly-installed histone contact staircase (shown by flashing lights during re-wrapping)
resulting in dimer replacement without any change in the translational position of the nucleosome
A large protein complex that carries out the DNA replication process
from the unwinding of double-stranded DNA to strand duplication by DNA synthesis
prevent histone aggregation and that can promote either nucleosome assembly or nucleosome disassembly
H3 and H4) that are most commonly assembled into nucleosomes during replication and that constitute almost all of the nucleosomes across the genome
Differ by a few amino acids from canonical histones and are expressed at low-to-moderate levels and typically inserted into nucleosomes independently of replication; they create specific chromatin regions and functions
Protein domains of helicases and remodellers
similar in structure and sequence to the ATPase domain of the Escherichia coli DNA-binding protein RecA
A measure of the extent of helical winding of the DNA strands around each other
Often expressed as the number of base pairs of DNA per helical turn in B-form DNA
A mechanical property of polymer stiffness
A pseudo-two-fold symmetry element of the nucleosome core particle
refers to one DNA wrap around the surface of the octamer
it describes the amount of DNA that is translocated per ATP hydrolysis and/or the probability that the enzyme conducts a DNA translocation step per ATP hydrolysis cycle
Nucleosome that lacks one histone H2A–H2B dimer
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The Col du Clapier-Savine Coche with Turin (upper left) off in the distance
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the secretory pathway kinase FAM20C phosphorylates the majority of secreted phosphoproteins
Members of the family of FAM20C-related kinases phosphorylate secreted proteins and proteoglycans
but the extent and mechanism of their action is unclear
The authors characterized FAM20C and revealed that the secreted portion of this peptide is truncated
that N-linked glycosylation is required for its correct folding and secretion and that it undergoes autophosphorylation
Previous work suggested that FAM20C phosphorylates Ser in the motif S-X-E/pS (where X is any amino acid and p indicates phosphorylation)
and the screening of a 198-peptide array showed that FAM20C strongly prefers Glu at the +2 position of this motif
and those related to the vertebrate lonesome kinase family of secreted kinases
suggesting that the specificity of FAM20C is unique among secretory pathway kinases
A single kinase generates the majority of the secreted phosphoproteome
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The pursuit of excellence — in scholarship
leadership and citizenship — is what defines a Sterling Scholar in the state of Utah
Each high school senior who is recognized and awarded has demonstrated knowledge
Each student is required to present a portfolio of work in a specific category
be interviewed by judges and advanced at the high school and finals levels
one overall Sterling Scholar winner is chosen and announced at an awards ceremony each year
The categories for the Northeast Region are Agriculture Science
The nominees for each school are as follows:
historians have argued over the route used by the Carthaginian general Hannibal to guide his army — 30,000 soldiers
37 elephants and 15,000 horses — over the Alps and into Italy in just 16 days
conducting a military ambush against the Romans that was unprecedented in the history of warfare
Such an achievement required careful planning and strategizing
but with little physical evidence of the journey available today and few recorded details of the crossing
uncertainty remains about how it was accomplished
In 218 B.C., when the crossing took place, the powerful nations of Carthage and Rome were at each other's throats
Hannibal did the unthinkable — he led an army through a mountain region spanning about 80,000 square miles (over 207,000 square kilometers) — and descended on Rome from the north
The most obvious route for Hannibal to have taken through the Alps is called the Col du Clapier
a lecturer in ancient history at Cardiff University in the U.K.
but offered far quicker passage through the mountains
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"That's key — it was the fastest route
This also supports historical accounts by the Greek historian Polybius
and who described Hannibal choosing "the highest paths" for his army
Compounds that are found in horse manure were plentiful in the sediment
an army-size group of horses likely relieved themselves while resting
according to the filmmakers' statement.
on coins from Carthage depicting realistic representations of elephants
the animals closely resemble the African species in the size and shape of their ears
raising the possibility that the Carthaginians were importing their elephants from northern Africa
Hannibal's elephants may have represented a smaller
now-extinct subspecies of African elephant; historical accounts described northern African war elephants as fearful of the bigger Indian war elephants
while modern Asian elephants are generally smaller than their African cousins
Elephants require vast quantities of food — about 220 lbs
(100 kilograms) per day — which the army would have needed to bring along with them
as there wasn't anything for the animals to eat along the way
But the elephants would likely have handled the terrain and the distance quite well
as they frequently have to cover great distances and cross mountain passes in both Africa and in the Himalayas
Ultimately, Hannibal's brazen maneuver — elephants and all — couldn't save Carthage, which Rome defeated in the Second Punic War (218 B.C
his ambitious journey still fuels imaginations and raises intriguing questions about achieving the seemingly impossible — for people and for elephants
"Secrets of the Dead: Hannibal in the Alps" airs April 10 at 8 p.m. EDT on PBS (check local listings) and is available to stream on April 11 via pbs.org/secrets and PBS apps
Original article on Live Science
Mindy WeisbergerSocial Links NavigationLive Science ContributorMindy Weisberger is an editor at Scholastic and a former Live Science channel editor and senior writer
Mindy studied film at Columbia University; prior to Live Science she produced
wrote and directed media for the American Museum of Natural History in New York City
biodiversity and evolution appear in museums and science centers worldwide
earning awards such as the CINE Golden Eagle and the Communicator Award of Excellence
Her writing has also appeared in Scientific American
The Washington Post and How It Works Magazine
Her book "Rise of the Zombie Bugs: The Surprising Science of Parasitic Mind Control" will be published in spring 2025 by Johns Hopkins University Press
Scientific consensus shows race is a human invention
May's full 'Flower Moon' will be a micromoon
Did Elizabeth Smart and her kidnappers spend several months last summer hiding out in Dry Canyon
they could have lived in relative obscurity in that canyon's rarely traveled south fork
Mountain bikers regularly frequent the lower portion of the main canyon
because it's a fairly smooth portion of the Bonneville Shoreline trail
which splits to the right about two miles up
Salt Lake City police jealously guarded a primitive campsite Thursday afternoon
located three miles from the University of Utah Hospital in the south fork of Dry Canyon
It's almost a mile off the main trail in the area
The mouth of this canyon is located about four miles northeast of the Ed Smart home
The canyon is also found between the "U" block on the mountainside and the U
Several reporters headed to a possible campsite were turned back by authorities Thursday afternoon
"Turn around or you'll be arrested," a police officer yelled to two reporters as they approached a primitive camp in the upper canyon that was marked with some clothes and other items that helicopter news crews had seen from the air
Keith Clapier of Parley's Summit was in Dry Canyon with his mountain bike and dog
Thursday and said he's been in the area more than a hundred times
"I've seen runaways up here," he said
explaining he could find better places to hide but agrees there's so much oak brush in the canyon that the south fork would be a place where you would see few visitors
they could come up in the canyon just after dark and probably never be noticed
Clapier also found a sleeping bag and two pairs of old hiking shoes in the lower part of the canyon that someone had recently discarded
He said there's a narrow cave in the canyon that could be used for shelter
several seeps of water and a year-round spring of water near the mouth of the canyon
Reporters also found the bones of two small animals along the upper south fork trail
Almost all of the trail has a very gradual incline
say there's another spring of water higher up the canyon
Kelner's not surprised that someone could hide out in Dry Canyon
not to be confused with a different canyon by the same name that's south of Little Cottonwood Canyon
"There are a lot of possibilities up there to hide in," Kelner said
"It's not on the beaten path."
Green said he hasn't been in the area much the past eight years after retiring from a job at the U
"A surprising number of people use it," he said
more than three dozen mountain bikers alone used the lower canyon in a two-hour period Thursday afternoon
Nichols of Salt Lake wrote the book "Trails of the Wasatch" in the late 1990s
an old stove and bed parts in the upper portion of the south fork
which eventually reaches the Black Mountain Ridge
There are a few small patches of snow two or more miles up
but otherwise no water is visible along the trail
Kelner feels someone could survive there in the summer
"The spring is well hidden," he said
There are also some small mammals living in the area
E-MAIL: lynn@desnews.com