research is revealing how to shift your mental state and put bad feelings to good use – with benefits for longevity By David Robson Ethan Kross always shared a special bond with his grandmother whom he considered a “second mom” She lived just a few blocks away from his childhood home she would shower him with kisses and lavish him with food – matzo balls she would barely ever talk about the horrors she had endured during the Nazi occupation in Eyshishok before she had emigrated to the US and found a home in New York How did she rebuild her life to become such a stable figure for her family except on specific occasions like Holocaust Memorial Day how she could mostly avoid speaking about those events but still be OK,” says Kross Read more The new evidence that explains what anxiety really is Such questions would follow Kross through his adolescence; as an experimental psychologist and director of the Emotion and Self Control Lab at the University of Michigan “Emotions are full of richness and utility but they can also get the better of us when we are most vulnerable,” he says And what can we do to handle them more effectively That’s what I went to graduate school to figure out.” Shift: How to manage your emotions so they don’t manage you He also isn’t the only psychologist fascinated by the idea of mastering our… A new wave of ocean scientists has embarked on an extraordinary six-week voyage aboard a majestic tall ship that set sail today from Norway bound for southern France Thanks to this ESA Advanced Ocean Training Course these upcoming researchers will be taking a deep dive into ocean science empowering them with skills to harness satellite data for research innovation and sustainable development – and preparing them to become tomorrow’s leaders and ambassadors for ocean science support the livelihoods of over three billion people United Nations Special Envoy for the Ocean “There can be no healthy planet without a healthy ocean and the ocean’s health is currently measurably in decline.” So, it is especially fitting that this extraordinary voyage sets sail today, 22 April Earth Day 2025 – a day when people around the world unite to raise awareness about environmental protection and to take action against climate change “The importance of oceans to our planet cannot be over-estimated oceans are dynamic and involve complex processes that have huge implications for the health of our planet and all living things our understanding of ocean science has come on leaps and bounds the demand for ocean resources rising and shipping routes busier than ever it is imperative that we continue to advance our scientific knowledge and understand how oceans are being impacted so that “Thanks to high-quality and frequent measurements from satellites we can now observe the global ocean every few days – transforming our ability to understand and protect this vast blue ecosystem arguably with the best Earth observation programme in the world passing on know-how to the next generation of scientists is our duty so that they are not only equipped but also inspired to find new ways of using satellite data to understand and help safeguard our planet for the future – which is the purpose of ESA’s hands-on Ocean Synergy Training Course.” Setting sail from Tromsø today, the Statsraad Lehmkuhl tall ship is now home to 50 students and over 20 lecturers and ocean experts over 40 citizen scientists will actively participate in the scientific research conducted aboard the ship In a message to those participating in this remarkable voyage “You will return home having changed the world just a little in that you are also a scientific expedition You will return home with a cargo of knowledge And that is something that we all need in these times of climate change “We need all the knowledge we can get about the ocean It is said we know more about the moon than the deep sea this is a journey of adventure and of discovery A journey of excitement for both the individual and society.” Throughout the six-week voyage to Nice in France with stops in Reykjavik in Iceland and the island of Menorca in Spain students will not only learn about satellite oceanography via lectures but importantly they will be emersed in a demanding programme of taking in situ measurements and analysing near-realtime satellite data to compare with measurements taken from the ship and with ocean model fields The ship’s arrival in Nice on 3 June comes at a crucial moment, just ahead of the United Nations Ocean Conference starting on 9 June The conference seeks to galvanize urgent action to conserve and sustainably manage oceans while advancing the implementation of Sustainable Development Goal 14 Notably, the ESA Advance Ocean Training Course is part of the year-long One Ocean Expedition – a scientific and educational voyage around the Northern Hemisphere oceans with the overarching goal of drawing attention to and sharing knowledge about the ocean’s crucial role for a sustainable future in a global perspective It is an important and timely contribution to the United Nations Decade of Ocean Science for Sustainable Development “With Earth science at cornerstone of our ESA Earth Observation Programmes we are proud to contribute to the One Ocean Expedition “It is our sincere hope that all participants in this training course make the most of this unique opportunity – to deepen their knowledge refine their skills and emerge better prepared to advance the field of satellite oceanography as they progress in their scientific careers.” The importance of investing in our future ocean scientists is recognised by institutes sponsoring ESA’s Advanced Ocean Training Course including Ocean Data Laboratory (France) the Nansen Environmental and Remote Sensing Center (Norway) the Trevor Platt Science Foundation (India) and the Statsraad Lehmkuhl Foundation (Norway) international students beyond Europe are able to participate in the scientific voyage Follow the ESA Advanced Ocean Science Blog for updates There are no statistics available for this player Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Wire harnesses are the backbone of industries like automotive They bundle multiple wires and cables into a package ensuring organized and efficient electrical connections assembling these harnesses has been a manual despite various attempts to automate this process the results have neither achieved fully automated wire harness manufacturing nor effectively managed wire routing.  That’s not to say that wire harness automation hasn’t made significant strides in tasks like cutting sophisticated and often costly machines can be used to achieve a high degree of automation to boost the efficiency and precision of repetitive tasks such as wire preparation attaching terminals and routing wires into the correct position Automated soldering and testing systems have also improved consistency and quality.  these systems are essentially automated versions of manual processes The inherent complexity of wire harness designs — different wire lengths connector types and routing configurations — has always required manual intervention as current robotic systems aren’t able to fully adapt to these intricacies To tackle these challenges, a fully automated wire harness manufacturing technology has been developed using cartesian robotics and additive manufacturing to integrate bare or insulated wires directly onto or within product components. Known as Electrical Function Integration, this method employs proprietary CAD/CAM robotic manufacturing cells developed by Q5D.  The self-contained units are designed for autonomous operation and require only power and internet connectivity to move and position tools with high precision in three-dimensional space — an essential requirement for accurately placing wires and conductive tracks in complex geometries.  Built on a tubular steel frame with impact-resistant polymer cladding the cells feature a five-axis motion control system comprising three linear axes and two rotational axes The system employs high-speed linear motors for the X and Y axes (up to 1 m/s) and Z axis (up to 0.5 m/s) to maximize accuracy.  Hollow motors control the rotational axes (normal speed 70 rev/min max 200 rev/min) to deliver precision movements of the linear axis within ±5 ?m on the B-axis within ±30 arc sec and on the C-axis within ±10 arc sec The system achieves better than ±50 microns accuracy at any point within the build volume and throughout the programmed path of movement.  To deliver this accuracy, the cell features a custom motion controller and post-processor along with Siemens NX CAD/CAM software to execute complex 3D movements for precise wire laying and polymer deposition.  Using the five-axis robotic cell technology to integrate electrical wiring directly onto vehicle headliners enables a single robot cell to affix the wiring into 30,000 headliners annually The system supports the deposition of industry-standard wires as well as a range of glues — such as hot melt and epoxy — to secure wires in place It can also work with a wide variety of polymers enabling accurate and directional placement of materials in the planned tool path By integrating wiring directly into product structures this method eliminates the need for additional materials reducing overall product weight and improving efficiency It also minimizes material waste and manual labor leading to substantial cost savings and supporting on-demand production This reduces the need for extensive inventories and associated storage costs while allowing for greater customization and adaptability in wire harness design without extensive retooling Wires and connectors need to handle electrical loads mechanical stress and operating conditions like high temperatures Depending on specific industry requirements different types of wires — such as single-core for simple connections or fiber optic for high bandwidth — are chosen based on the application’s requirements The choice of routing configuration also impacts the overall performance of a wiring harness affecting factors such as signal integrity electromagnetic interference and ease of maintenance Electrical Function Integration considers all these factors — evaluating conductivity adhesion properties and automatic termination capability An advantage of this method is that it typically allows manufacturers to use their existing wires without any modifications The chosen wires must be compatible with additive manufacturing techniques and withstand the product's overall environmental conditions.  A crucial factor involves ensuring the choice of glue or polymer is compatible with the wire and the substrate or part onto which the wire is to be attached.  The 3D polymer process in Q5D’s Electrical Function Integration technology uses five-axis manufacturing to deposit polymers in complex 3D shapes This capability enables the creation of wire traps insulates connectors and bare wires and forms 3D features.  This helps minimize product weight by securely anchoring and supporting wires in a permanent position allowing for the use of thinner or lighter wires tailored to the required conductivity in traditional wire harnesses the wire size is adversely influenced by the lack of control over mechanical stresses experienced during manufacturing often necessitating larger wire sizes.  vehicles now need complex electrical systems for safety features Evaluation has shown that using five-axis robotic cell technology to integrate electrical wiring directly onto vehicle headliners can streamline the process allowing a single robot cell to affix the wiring into 30,000 headliners annually.  Aerospace companies see benefits from reducing weight and improving reliability Electrical Function Integration can potentially reduce the weight of each business-class seat by about five kilograms This weight reduction means planes can fly further and emit less carbon dioxide.  In the field of contactless communications traditional NFC card reader manufacturing involves a five-step process a single bare wire is laid onto an injection-molded part with automated terminations This approach can process up to 50 parts simultaneously cutting manufacturing steps by 60% and reducing takt time from 120 seconds to 15 seconds — an 87% improvement it eliminates the 30-day lead time from third-party suppliers by combining production and final assembly in one place Simon Baggott is chief marketing officer at Q5D Technologies Simon Baggott is chief marketing officer at Q5D Technologies He has more than 20 years of experience in connecting people with products across B2B and B2C technology businesses He has worked in both large multinational corporations such as BOC GE and JDR Cable Systems and in small to medium enterprises He holds a BEng degree in materials engineering from the University of Swansea SAN FRANCISCO, March 4, 2025 /PRNewswire/ -- Harness, the AI-Native Software Delivery Platform™ company, announced it has completed its merger with Traceable Harness and Traceable are creating the most advanced AI-native DevSecOps platform enabling software teams to seamlessly develop The combined platform eliminates the need for separate security and software delivery solutions integrating security directly into every stage of the development lifecycle With the rise of AI-driven development and increasing security threats enterprises need a unified approach that ensures applications are secure by design This merger delivers on that need by combining Harness' expertise in software delivery with Traceable's leading API security capabilities For more information, please visit www.harness.io About HarnessHarness is the leading AI-native platform for complete software delivery and secure way for engineering and DevOps teams to release applications into production Harness uses AI and machine learning to monitor the quality of deployments and automatically roll back failed ones saving time and reducing the need for custom scripting and manual oversight giving engineers their nights and weekends back and decrease lead time for changes by up to 90% and is backed by industry-leading investors like Menlo Ventures the next-generation AI-Native DevSecOps Platform™ company today announced that SecureIQLab has recognized Traceable by Harness as a Leader.. the AI-Native Software Delivery Platform™ company Computer & Electronics Computer Software Computer Software High Tech Security Do not sell or share my personal information: DevOps.com Harness Merges with Traceable to Provide Integrated DevSecOps Platform By: on February 10 Harness today announced that Traceable will be merged into the company to create a combined company that will further advance the adoption of best DevSecOps practices across the software development lifecycle (SDLC) Created to focus specifically on application programming interface (AP) security Traceable and Harness both trace their lineage back to BIG Labs with Traceable CTO Sanjay Nagaraj now heading up application security said that as DevSecOps has evolved it’s become clear that software engineering teams are assuming responsibility for securing APIs alongside all the other artifacts that make up the software supply chain the need for a separate platform to solely focus on securing APIs becomes less of a requirement The overall goal is to make it simpler to share critical security information with application developers that enables them to create more secure applications without adding responsibility for ensuring those tasks are completed a DevSecOps platform should surface the right information a developer needs to know at the time when they are writing code developers are not going to have enough context to address an issue found in code they may have written weeks earlier cybersecurity teams should be able to define policies that are enforced by a DevSecOps platform that informs them whenever an issue arises With the rise of artificial intelligence (AI) the volume code that might have a security issue that needs to be addressed before being added to a software build is starting to exponentially increase Application developers are already struggling to keep pace with the volume of requests to create patches for existing applications The addition of code written by machines is only going to further exacerbate that issue There needs to be a platform that facilitates workflows in a way that in real time keeps all parties informed of security issues and how they are being addressed the melding of Harness and Traceable is in many ways the latest substantiation of a need to embrace platform engineering as a methodology for meaning DevSecOps workflows at scale It’s not clear to what degree the need to better secure software supply chains is driving organizations to replace their existing DevOps platforms but Harness has been making a case for an integrated platform that makes it simpler to apply artificial intelligence (AI) across the SDLC including the ability to enforce best application security practices is empowering all the stakeholders involved in a way that doesn’t make it too hard for application developers and software engineers to do the right thing by reusing a script that has already been vetted for cybersecurity issues individual members of a team will conclude it’s simply faster to write yet another script that they perceive as being the fastest way to achieve their end application deployment goal Regardless of DevSecOps maturity, the one thing that is certain with more attention than ever being paid to software supply chain security existing software engineering workflows will be finally revamped to fully address these longstanding concerns April 16, 2025 | April 10, 2025 | March 7, 2025 | February 25, 2025 | February 19, 2025 | © 2025 ·Techstrong Group, Inc.All rights reserved U.S. Trotting News New Zealand – The harness racing world is shocked and devastated following news of the tragic passing of decorated horseman Greg Sugars News of Sugars’ passing emerged on Saturday afternoon via the Instagram account of Larajay Farm “With an absolutely shattered heart that doesn’t want to believe it’s possibly true I need to share the news that Greg passed away in his sleep last night,” the post read “Greg had excitedly driven our team to NSW yesterday with none of us possibly predicting this was in our future “His beloved son (dog) Harvey doesn’t yet understand that Dad won’t be home to take him to Puppy School Graduation on Tuesday “We are heartbroken and very much still processing everything so some time and space will be appreciated.” Harness Racing Victoria cancelled Saturday night’s Melton meeting Sugars was in NSW at the time of his death with stable runners Fighter Command son of highly decorated former SA trainer Ross Sugars was one of the stars of Australian harness racing It was only in January this year that Sugars and Tubbs called time on the remarkable career of their once in a lifetime global trotting superstar Just Believe The champion square-gaiter won 38 races during his career banking almost $2 million in prize money where he completed in three countries and two hemispheres He enjoyed huge success in NZ last year with wins in the TAB Trot What is the USTA? Become a Member Renew Discounts Free Account Member Services Department Directory MyAccount Hoof Beats Magazine kitta.macpherson@rutgers.edu Researchers at Rutgers University-New Brunswick have developed an artificial intelligence (AI) tool that will help predict endangered whale habitat guiding ships along the Atlantic coast to avoid them The tool is designed to prevent deadly accidents and inform conservation strategies and responsible ocean development.  The researchers’ report was published in Nature Scientific Reports The effort was led by Ahmed Aziz Ezzat, an assistant professor in the Department of Industrial and Systems Engineering at the School of Engineering, and Josh Kohut, a professor in marine sciences who in January became dean of research at the School of Environmental and Biological Sciences Ezzat leads a research group on applied machine learning for engineering and physical sciences the paper’s first author and a doctoral student in the School of Engineering This is a demonstration of the power of employing AI methodologies to advance our ability to predict or estimate where these whales are Dean of Research at the School of Environmental and Biological Sciences Kohut likened the output of the program to what might be learned by tracking the movements of people in a house as well as determining whether there is food in the kitchen and a television set on in the den Such factors might determine why people are where they are at certain times of the day we’re correlating the position of a whale in the ocean with environmental conditions,” Kohut said “This allows us to become much more informed on decision making about where the whales might be We can predict the time and location that represents a higher probability for whales to be around This will enable us to implement different mitigation strategies to protect them.” the researchers sought to develop high-resolution models of the North Atlantic right whale presence to support responsible offshore wind farm development and operation But they said the results have far broader implications and have made the details public as an addendum to their research paper.  “These tools are valuable and would solidly benefit anyone engaged in the blue economy – including fishing shipping and developing alternative forms of energy sustainably,” Ezzat said “This approach can support a wise and environmentally responsible use of these waters so that we achieve our economic objectives and at the same time make sure that we cause minimal to no harm to the environmental habitat of these creatures.” where instructions are explicitly written out the machine-learning program employed by the researchers analyzed large data sets to discover patterns and relationships it adjusted its internal model to make better predictions or classifications “The outcome of the machine-learning model is basically a prediction of where and when you will have a higher likelihood of encountering a marine mammal,” Ezzat said describing what he characterized as a “probability map.” The information analyzed by the computer model includes all the underwater glider and satellite-based data collected by scientists at the Rutgers University Center for Ocean Observing Leadership dating back to 1992 when it was established by then assistant professor Scott Glenn now a distinguished professor in the Department of Marine and Coastal Sciences The analysis also included satellite data products made publicly available by the University of Delaware The underwater gliders are autonomous torpedo-shaped vessels that zip along under the ocean surface of the mid-Atlantic coast They are designed to measure many different aspects of seawater The gliders also bounce sound waves off schools of fish to gauge their size and record the underwater calls of whales and other marine mammals Satellite data includes measurements of sea surface temperature we’ve not been able to put the two sets – those detections of where the whales are and what the environment is like at those places – together,” Kohut said “This is a demonstration of the power of employing AI methodologies to advance our ability to predict or estimate where these whales are.” Other Rutgers scientists on the study included: Laura Nazzaro a lab manager in the Department of Marine and Coastal Sciences; and Jeeva Ramasamy an undergraduate majoring in computer science Rutgers is an equal access/equal opportunity institution. Individuals with disabilities are encouraged to direct suggestions, comments, or complaints concerning any accessibility issues with Rutgers websites to accessibility@rutgers.edu or complete the Report Accessibility Barrier / Provide Feedback form Copyright ©2025, Rutgers, The State University of New Jersey. All rights reserved. Contact webmaster New integrations bring tangible AI value to Software Development the Modern Software Delivery Platform® company today announced it has expanded its strategic partnership with Google Cloud focusing on new integrations leveraging generative AI technologies This collaboration enhances the developer experience across engineering teams by embedding generative AI throughout the development lifecycle modern software development teams can embrace a data-driven culture of continuous innovation and improvement This initiative emerges as a pivotal solution for organizations grappling with software delivery velocity and the struggle to identify issues early in the development processes The expanded partnership provides a strategic path to achieve engineering excellence by optimizing software development practices "We are thrilled to deepen our partnership with Google Cloud bringing transformative AI capabilities to the software development lifecycle," said Jyoti Bansal "Our combined solutions empower engineering teams to innovate continuously This collaboration marks a significant step forward in our mission to modernize how software is developed and provide engineering teams with the tools they need to succeed in a data-driven world." "Our partnership with Harness allows us to deliver unparalleled AI-driven insights and reliability enhancements to developers," said Gabe Monroy VP of Developer Experience at Google Cloud "The integration of Harness AI Productivity Insights with Gemini Code Assist provides customers with deeper visibility into developer productivity gains unlocked by AI code assistants We look forward to continuing to see the positive impact this collaboration will have on the software development community." "The solutions from Harness and Google Cloud have been game-changers to our software development process," said Sanjeev Hasiza Head of Software Development & Director of Enterprise Architecture at Johnson Controls.  "We're excited to see these two industry leaders deepen their collaboration These integrations will have a significant impact on our team's productivity and application reliability and empower us to innovate faster and deliver higher-quality software." To learn more about these integrations, please visit https://www.harness.io About HarnessHarness is the leading end-to-end platform for complete software delivery Harness customers accelerate deployments by up to 75% announced it has completed its merger with Traceable Cloud Computing/Internet of Things Strategic combination creates the world's most advanced AI-Native DevSecOps Platform SAN FRANCISCO, Feb. 10, 2025 /PRNewswire/ -- Harness, the AI-Native Software Delivery Platform™ company, and Traceable today jointly announced they have entered into a definitive merger agreement creating the world's most advanced AI-native DevSecOps platform.  Together Harness and Traceable will enable software teams to seamlessly develop ensuring security is embedded at every stage of the software lifecycle Harness and Traceable both originated from BIG Labs a San Francisco-based technology startup studio founded by Jyoti Bansal who is CEO and co-founder of both companies Harness was launched in 2017 with a mission to simplify software delivery for software developers around the world and has since grown into a full-fledged suite of industry-leading product modules that span the entire software delivery lifecycle Traceable was launched in 2020 to secure trillions of lines of code and millions of APIs that modern software runs on and is rapidly growing into a complete application security platform Both companies are backed by industry leading investors like Unusual Ventures This merger builds on both companies' shared innovation-based DNA and leadership philosophy to redefine the future of software delivery DevOps and Application Security Converge to Give Rise to the Next Generation of DevSecOps With 37 million software developers worldwide the pace of software development is faster than ever driven by AI-generated code and increasing market demands software teams continue to face challenges in balancing velocity and security focused solely on network and infrastructure protection are no longer sufficient to prevent sophisticated cyber attacks requiring deep integration between development and security teams to proactively mitigate risks Engineering and security teams are rapidly converging as enterprises bring security to the forefront of their application design software development teams increasingly want a unified approach integrating security and compliance directly into their software development and delivery processes cyber-resilient software delivery pipeline has never been higher and this trend is giving rise to the next generation of DevSecOps platforms Harness and Traceable are setting a new standard for teams to seamlessly develop and protect applications and ensure security is built into every step of the software development lifecycle—from design to runtime "Harness and Traceable are coming together at a pivotal moment in the industry," said Jyoti Bansal CEO and co-founder of Harness and Traceable "Software teams should not have to choose between speed and security when delivering innovation to their customers The mutual interest from Harness and Traceable customers in an integrated DevSecOps platform has substantially accelerated over the last year and the timing is right to deliver on this industry demand By merging these industry-leading solutions we will bring a next-generation DevSecOps platform to the market setting a new standard for software delivery." "As a customer of both Harness and Traceable this merger is a game-changer for us," said Jignesh Patel Director Cloud & DevOps at Morningstar "Having an integrated platform that seamlessly connects software development and API security dramatically enhances our developer experience enabling us to innovate faster while maintaining the highest security standards By delivering a consistent user experience and deep product integrations remove the toil that slows our developers down and empower them to focus on what matters most The combination of Harness and Traceable will provide the solution that enterprises and developers have been waiting for." Powering the Next Wave of AI-Native DevSecOps Agents and Harness and Traceable are at the forefront of this transformation they are building a robust library of AI-native agents that enhance software delivery's speed Agentic AI in the unified DevSecOps platform will leverage two unique datasets: software development and delivery process data from Harness as well as API-driven application usage and security patterns from Traceable the AI agents will optimize and secure every stage of the software delivery lifecycle giving organizations a competitive edge in an increasingly complex landscape "This merger creates the most compelling AI-native platform for software teams to deliver safe scalable code to their end users," said Steve Harrick "The market demand for security to become a core part of the software development process has never been greater leading to the swift convergence of these markets Harness and Traceable are not just keeping up with this evolution—they're leading it a visionary who has repeatedly built industry-defining companies this combination is set to redefine how modern software is developed my close friend and co-founder at Unusual Ventures building three iconic enterprise companies and redefining entire industries," said John Vrionis Founder and Managing Partner at Unusual Ventures "His foresight in uniting DevOps and Security—now supercharged by AI—will give customers an unprecedented advantage and I'm proud to be his partner in building the next great enterprise software company." For more information, please visit https://www.harness.io/blog/harness-traceable and is backed by industry leading investors like Menlo Ventures, IVP About Traceable AITraceable's intelligent and context-aware solution powers complete API security and attack protection anywhere your APIs live Traceable enables organizations like Axos Bank and Navan to minimize risk and maximize the value that APIs bring their customers Traceable is backed by industry leading investors like Unusual Ventures Defense leaders are creating new pathways to scale emerging technologies like AI enabling faster innovation and empowering end users Leaders across the Defense Department are creating new innovation pathways to bring in and scale emerging technologies like artificial intelligence to empower the end user, federal tech experts explained during the GovCIO Media & Research Defense IT Summit in Arlington The rapid advancement of emerging technologies has accelerated the need for government to innovate and adopt solutions quickly ensuring it stays competitive and ahead of the curve Collen Roller senior computer scientist at the Air Force Research Laboratory (AFRL) is working to create pipelines to bring new capabilities to end users and stressed the need for better pipelines to support innovation “There’s not that many ways to get capabilities built and out there really important that we create pipelines and ways to do that,” Roller said “[The lack of pathways to innovate] turned into me creating a software factory where I could bring innovators together and try to deploy and deliver capabilities to end users.” Roller, AFRL NIPRGPT creator built a software factory and dedicated a significant amount of time to determining how to implement the right security measures obtain full authority to operate for the environment and develop the most cost-effective way to innovate “If you give them a path to the end state which is delivering something to an end user or customer And it’s amazing to see … where we have specifically seen literally hundreds of developers band together to build capabilities for folks And it’s been truly amazing to witness people coming out of the woodwork to help out with building certain products to benefit the end user,” said Roller is that many of the web applications needed for data management are not particularly difficult to build “GenAI gives a non technical expert the ability to build simple applications very “If you’re not using GenAI in 2025 you’re slow at your job … We really need to lean in to GenAI adoption because it’s going to change everything.” Federal leaders are facing new challenges in data management as the amount of digital information only increases DOD’s Cyber Crime Center (DC3) is exploring innovative ways to leverage emerging data types to advance its mission while integrating AI to empower its workforce to process information more efficiently DC3 Chief Scientist Lam Nguyen explained how data is constantly being exchanged between devices leaving a trail of virtual breadcrumbs for investigators to follow “My smart watch might have talked to your home security system,” said Nguyen “That is very tangible evidence that we can collect if we know to collect it and if we know what to do with it once it’s been collected.” Nguyen and his team are trying to address the challenges posed by data collection He said AI will play a large role in helping investigators perform their jobs better emphasizing that the technology will not be a replacement and somebody needs to go read through that if they’re doing an analysis or an investigation on your phone Wouldn’t it be nice if AI could just summarize those conversations,” said Nguyen “We’re not looking at it from an autonomous perspective We’re looking at it from a control perspective that makes our work easier.” Program Executive Officer for Digital and Enterprise Services (PEO Digital) at the Department of the Navy Louis Koplin has witnessed his team excel on projects because of scaling adoption and innovation “We know [that if] you get the right people in the right context with the tools and the infrastructure and the domain knowledge you can go really fast,” said Koplin He highlighted the success of Navy’s Flank Speed initiative initially developed during the COVID-19 pandemic which aimed to replicate the success of commercial virtual remote tools like Microsoft 365 in a secure environment Partnering with other agencies within the DOD Koplin’s team investigated how the success could be scale more broadly across the department “You can’t jump right to an enterprise service “We were able to really partner with them in that DevOps mode where the operators are driving … and we were able to scale that Koplin emphasized the importance of having people who can speak to the capabilities and trustworthiness of new tools or strategies is a part of strategic communication efforts Providing open door conversations and over communicating increases transparency into the tech and the strategy supporting it “Doing all that on their behalf and then coming in as a trusted speaker in this realm is huge and that’s really the key to adoption,” said Koplin I am telling you this thing is going to help and it is going to make your life better.’” Metrics details factors and particular hepatocyte population influencing its efficiency remain unclear Here we report on a unique regeneration mechanism involving unconventional RPB5 prefoldin interactor 1 (URI1) binds to and activates glutamine synthase (GS) in pericentral hepatocytes Genetic GS or URI1 depletion in mouse pericentral hepatocytes increases circulating glutamate levels accelerating liver regeneration after two-third hepatectomy mouse hepatocytic URI1 overexpression hinders liver restoration which can be reversed by elevating glutamate through supplementation or genetic GS depletion Glutamate metabolically reprograms bone-marrow-derived macrophages which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation GS regulation by URI1 is a mechanism that maintains optimal glutamate levels probably to spatiotemporally fine-tune liver growth in accordance with the body’s homeostasis and nutrient supply including in cirrhotic mice with low glutamate levels and in early mortality after liver resection as well as in mice undergoing 90% hepatectomy glutamate addition enhances hepatocyte proliferation and survival URI1 and GS expression co-localize in human hepatocytes and correlate with WNT3 in immune cells across liver disease stages Glutamate supplementation may therefore support liver regeneration benefiting patients awaiting transplants or recovering from hepatectomy Prices may be subject to local taxes which are calculated during checkout Is liver regeneration key in hepatocellular carcinoma development Spatiotemporal metabolic liver zonation and consequences on pathophysiology Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver AXIN2+ pericentral hepatocytes have limited contributions to liver homeostasis and regeneration Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration Broad distribution of hepatocyte proliferation in liver homeostasis and regeneration In vivo lineage tracing of polyploid hepatocytes reveals extensive proliferation during liver regeneration Liver homeostasis is maintained by midlobular zone 2 hepatocytes Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair Spatial sorting enables comprehensive characterization of liver zonation A comprehensive analysis of prefoldins and their implication in cancer Inhibition of de novo NAD+ synthesis by oncogenic URI causes liver tumorigenesis through DNA damage A spatiotemporal atlas of mouse liver homeostasis and regeneration Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations URI is required to maintain intestinal architecture during ionizing radiation Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse Retinal amino acid neurochemistry of the southern hemisphere lamprey A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice Glutamine synthetase deficiency in murine astrocytes results in neonatal death Monosodium glutamate as a palatability enhancer in the European diet Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice Immunology in the liver–from homeostasis to disease EAAT expression by macrophages and microglia: still more questions than answers Liver macrophages in tissue homeostasis and disease ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates Hypoxia-inducible factor-1α is a positive factor in solid tumor growth Conditional gene targeting in macrophages and granulocytes using LysMcre mice The RSPO-LGR4/5-ZNRF3/RNF43 module in liver homeostasis Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease CZI Cell Science Program et al. CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data. Nucleic Acids Res. https://doi.org/10.1093/nar/gkae1142 (2023) FIMO: scanning for occurrences of a given motif YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response A new conditional Apc-mutant mouse model for colorectal cancer Inactivation of the β-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals Glutamate as a neurotransmitter in the healthy brain A simple practice guide for dose conversion between animals and human Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase Garrido, A. et al. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. J. Hepatol. https://doi.org/10.1016/j.jhep.2021.12.019 (2021) TCPOBOP-induced hepatomegaly and hepatocyte proliferation are attenuated by combined disruption of MET and EGFR signaling Effects of portal-systemic shunt following 90% partial hepatectomy in rats Role of platelets on liver regeneration after 90% hepatectomy in mice Resolving the fibrotic niche of human liver cirrhosis at single-cell level Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer Hepatocellular carcinomas originate predominantly from hepatocytes and benign lesions from hepatic progenitor cells Metabolic inflammation-associated IL-17A causes non-alcoholic steatohepatitis and hepatocellular carcinoma HIF-1α is essential for myeloid cell-mediated inflammation Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury Monocyte recruitment during infection and inflammation Hepatic macrophage responses in inflammation Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice MCRS1 binds and couples rheb to amino acid-dependent mTORC1 activation Associating portal embolization and artery ligation to induce rapid liver regeneration in staged hepatectomy Percentage of future liver remnant volume before portal vein embolization influences the degree of liver regeneration after hepatectomy Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice Regulation of OGT by URI in response to glucose confers c-MYC-dependent survival mechanisms S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling Disrupting hierarchical control of nitrogen fixation enables carbon-dependent regulation of ammonia excretion in soil diazotrophs featureCounts: an efficient general purpose program for assigning sequence reads to genomic features UCell: robust and scalable single-cell gene signature scoring Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance Download references We thank all mouse providers as described in the Methods; the staff at the CNIO Units particularly the Mouse Genome Editing Core Unit and Animal Facility for the mouse re-derivation and maintenance respectively; the members of the CNIO Genomics Unit for generating scRNA-seq and mRNA-seq data; R Gonzalez-Rodriguez for their assistance in purifying recombinant WNT3 ligand; C Santiveri for her assistance in preparing the NMR samples; the patients and the staff at the Biobank Hospital Ramón y Cajal-IRYCIS (B.0000678) integrated in the Platform ISCIII Biobanks and Biomodels (PT20/00045) integrated in the Spanish National Biobanks Network are recipients of a Severo Ochoa-FPI PhD fellowship from the Spanish Ministry of Science and Innovation are recipients of a PhD fellowship from the Asociación Española Contra el Cáncer (AECC) supported by the State Research Agency (AEI 10.13039/501100011033) from the Spanish Ministry of Science and Innovation (PID2021-122695OB-I00) also including the iDIFFER network of Excellence (RED2022-134792-T) cofunded by European Regional Development Fund (ERDF) by the BBVA Foundation grants for biomedicine (EIC21−1-243) This work was developed at the CNIO funded by the Health Institute Carlos III (ISCIII) and the Spanish Ministry of Science and Innovation Present address: KNU G-LAMP Research Center These authors contributed equally: Mariana Angulo-Aguado Centro Nacional Investigaciones Oncológicas (CNIO) Spectroscopy and Nuclear Magnetic Resonance Unit designed all experiments and analysed the data with N.D flow cytometry experiments and data quantifications designed and supervised the study and secured funding The authors declare no competing interests Nature thanks Frank Tacke and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Heatmap from analysis of the mouse spatiotemporal liver cell atlas (CNP0002310) showing Uri1 co-expression correlated with Glul in mouse livers Confocal microscopy image of co-immunofluorescence (IF) staining of URI1+ and GS+ cells in wild-type mouse (left panel) and healthy human (right panel) liver Representative images of co-IF staining (left panel) and quantification (right panel) of URI1+ and oxalacetate (OAT)+ cells in wild-type mouse liver Representative confocal microscopy image of co-IF staining (left panel) and quantification (right panel) of URI1+ and OAT+ cells in healthy human livers Representative images of co-IF staining (left panel) and quantification (right panel) of URI+ and E-cadherin (ECAD)+ cells in wild-type mouse liver Representative confocal microscopy image of co-IF staining (left panel) and quantification (right panel) of URI1+ and E-cadherin+ (ECAD+) cells in healthy human livers Representative confocal microscopy images of co-IF staining of URI1+ and GS+ cells in livers from Uri1(+/+)Hep and Uri1(Δ/Δ)Hep mice Schematic representation of the generation of Uri1CreERT2;CAG-KFP mouse model Schematic representation of mouse treatment with 4-hydroxytamoxifen intraperitoneally injected every day for 1 week Representative confocal image of co-IF staining of Katushka (KFP)+ and GS+ cells in livers from mice described in k and l All representative experiments have been performed with at least three independent biological replicates Source data Unpaired two-tailed Student’s t test was used for statistical analysis Source data Representative confocal microscopy images of co-IF staining of URI1 and GS in livers of C57BL/6 mice at three timepoints following hepatectomy Quantification of GS+ cells in livers of C57BL/6 mice after hepatectomy (n = 3 mice per timepoint) Quantification of URI1+ cells in pericentral hepatocytes in livers of C57BL/6 mice after hepatectomy (n = 3 mice per timepoint) Liver-to-body weight ratio of C57BL/6 mice following hepatectomy (n = 3 mice per timepoint) Quantification of co-IF of Ki-67+/HNF4α+ cells in livers from C57BL/6 mice after hepatectomy (n = 3 mice per timepoint) (h) and CD20+ cells (*P = 0.05) (i) in livers from C57BL/6 mice after hepatectomy (n = 3 mice per timepoint) in livers from C57BL/6 mice after hepatectomy (n = 3 mice per timepoint) One-way ANOVA test was used for statistical analysis All representative experiments have been performed with at least three biological independent replicates Source data Ratios of liver-to-body weight (*P = 0.03) (a) and regenerated tissue (*P = 0.02) (b) of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice at different timepoints following hepatectomy (n = 3 mice per timepoint and genotype and at 24 h 5 (URI(+/+)Hep) and 7 (URI(+/Δ)Hep)) c,d Ratios of liver-to-body weight seven days after sham or hepatectomy surgery (n = 3 from left to right of x axis; *P = 0.02) (c) and regenerated tissue (n = 5 and 7; *P = 0.03) (d) of Uri1(+/+)Hep and Uri1(+/Δ)Hep male mice Ratios of liver-to-body weight seven days after sham surgery or hepatectomy (n = 3 from left to right of x axis; ***P = 0.001) (e) and regenerated tissue (n = 6 and 6; **P = 0.009) (f) of Uri1(+/+)Hep and Uri1(+/Δ)Hep female mice from left to right of x axis; *P = 0.04 ;0.02) after two weeks or two months sham surgery or hepatectomy (g) and regenerated tissue ratio (n = 3 4; *P = 0.02; **P = 0.01) (h) of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice Quantification of IHC of Ki-67+ cells in livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice after sham surgery or seven days two weeks or two months after hepatectomy (n = 3 per group; **P = 0.01) Representative images of γH2AX IHC staining in liversfrom Uri1(+/+)Hep and Uri1(+/Δ)Hep mice two weeks or two months after hepatectomy Quantification of Sirius Red staining in livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice two weeks or two months after hepatectomy (n = 3 per group) Quantification of IHC of SOX9+ cells in liversfrom Uri1(+/+)Hep and Uri1(+/Δ)Hep mice two weeks or two months after hepatectomy (n = 3 per group) WB of liver samples from Uri1(+/+)Z3 and Uri1(+/Δ)Z3 mice in Uri1(+/+)Z3 and Uri1(+/Δ)Z3 mice (n = 3 WB of liver samples from Uri1(+/+)Z1 and Uri1(+/Δ)Z1 mice in Uri1(+/+)Z1 and Uri1(+/Δ)Z1 mice (n = 3 Scheme for generating hURI1(+/KI)Hep Glul(+/Δ)Hep mice Liver-to-body weight ratio seven days post-sham surgery (n = 3) (r) or post-hepatectomy (n = 4 5; *P = 0.04; **P = 0.008; **P = 0.002) (s) as well as liver regenerated tissue ratio (n = 4 5; *P = 0.04; **P =0.002; *P = 0.02) (t) and liver Ki-67 IHC quantification (n = 3; *P = 0.03; 0.05) (u) in hURI1(+/KI)Hep Glul(+/Δ)Hep mice seven days post-hepatectomy Scheme for generating Uri1(+/Δ)Hep; Glul(+/Δ)Hep mice Scheme of hURI1(+/KI)Hep mice treated with glutamate in drinking water ad libitum one or seven days pre-hepatectomy and until the mice are sacrificed Relative Uri1 and different stem-cell markers mRNA levels in micro-laser-dissected pericentral hepatocytes (cv) from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 3; *P = 0.02) Representative confocal microscopy images of IF staining of KFP+ cells in livers from Uri1CreERT2;CAG-KFP(+/KI) mice 7 days one or two year after tamoxifen treatment in homeostatic conditions Quantification of IHC of Ki-67+ cells in different liver zones (central vein parenchyma and portal triad) from C57BL/6 mice (n = 3 per timepoint) (left panel) and Uri1(+/Δ)Hep mice (n = 3 per timepoint) (right panel) after hepatectomy unpaired two-tailed Student’s t test and Two-ways ANOVA (u) were used for statistical analysis Source data Representative images of IF of CD31+ cells (endothelial cells) and IHC of SOX9+ cells (cholangiocytes) αSMA+ cells (hepatic stellate cells) and Sirius red staining (fibrosis) in livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice Representative images of IHC (left panel) and quantification (right panel) of CD3+ cells (T cells) in livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice Representative images of IHC (left panel) and quantification (right panel) of CD20+ cells (B cells) in livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice Representative IF staining and quantification of CSF-1R+ cells in livers of Uri1(+/Δ)Hep mice (n = 11 hURI1(+/ΚΙ)Hep mice (n = 6; **P = 0.01) (f) 5; **P = 0.01; ***P = 0.001; ***P <0.0001) (g) and glutamate-untreated and treated hURI1(+/ΚΙ)Hep mice (n = 4; **P = 0.01) (h) 6; **P = 0.002; ***P = 0.001; ***P = 0.001) (i) and their respective controls Scheme of Uri1(+/Δ)Hep mice treated with BLZ945 via intraperitoneal injection administered every three days for a total of seven doses pre-hepatectomy Liver CSF-1R IF quantification post-treatment (n = 3 5; **P = 0.01) from Uri1(+/Δ)Hep mice as described in j Violin plot showing the expression levels of immune cell markers used to identify and annotate cell clusters from the scRNA-seq of livers from Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice Cell clusters derived from the scRNA-seq of livers from Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice along with their respective littermate control groups derived from the scRNA-seq of livers from Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice Gating strategy of flow cytometry used to analyse macrophages of livers from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice Quantification of Raw 267.4 cell number at different timepoints upon 5 mM glutamate treatment and increased concentrations of the glutamate transporter inhibitor (DL-TBOA) in the cell line Raw 267.4 treated one day with 5 mM of glutamate and/or 300 μM of DL-TBOA (n = 4; *P = 0.01; **P = 0.009) Scheme of irradiated hURI1(+/KI)Hep mice transplanted with bone marrow from hURI1(+/ΚΙ)Hep and Uri1(+/Δ)Hep mice pre-hepatectomy Area under the curve (p) and unpaired two-tailed Student’s t test were used for statistical analysis Source data Quantifications (left panels) and confocal representative pictures (right panels) of IF staining of CSF-1R+ cells in different zones parenchyma and central vein) in livers from Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice (n = 5 and 6; *P = 0.05; *P = 0.02; **P = 0.009) Quantification of IHC staining of CD3+ cells in different zones parenchyma and central vein in livers from Uri1(+/Δ)Hep mice (n = 3 per group) Quantification of IHC staining of CD20+ cells in different zones including the portal triad Representative pictures of IF staining of Glutamate+ and E-cadherin+ (ECAD+) cells in livers from Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice The zone inside the dashed lines represents zone 3 hepatocytes GSEA analysis at single-cell level of Hif1α target genes from livers of Glul(+/Δ)Hep versus their littermate control mice Violin plot of the genetic expression prolife at single-cell level of Hif1a in Kupffer cells from livers of Uri1(+/Δ)Hep and Glul(+/Δ)Hep mice along with their respectively littermate control mice WB of isolated BMDMs (F4/80+Ly6C+) from livers of hURI1(+/KI)Hep mice treated or not with glutamate WB of isolated BMDMs (F4/80+Ly6C+) from livers of Uri1(+/+)Hep WB of Raw 267.4 cell line cultured under hypoxic conditions treated with increased concentrations of glutamate for 4 or 24 h Fold change of total mean from succinate measured by NMR in Raw 267.4 cells treated with 5 mM glutamate and/or 5 μm of EGCG (n = 3 independent experiments per group; *P = 0.05; **P = 0.002 Model depicting the mechanism by which glutamate metabolically reprogrammes macrophages to stabilize HIF1α Scheme of irradiated Uri1(+/Δ)Hep mice transplanted with bone marrow from Hif1α(+/+)Myeloid and Hif1α(+/Δ)Myeloid mice Survival of bone marrow transplanted Uri1(+/Δ)Hep mice as described in l (n = 4 and 8; *P = 0.05) Ratios of liver-to-body weight (n = 4 and 3 from left to right of x axis; *P = 0.02) (n) and regenerative tissue (n = 4 and 3 from left to right of x axis; *P = 0.05) (o) of bone marrow transplanted Uri1(+/Δ)Hep mice Quantification of IHC of Ki-67+ cells in livers from bone marrow transplanted Uri1(+/Δ)Hep mice as described in l (n = 3 per group; *P = 0.05) Quantification of HepG2 cell number co-cultured in transwell plates with the cell line Raw 267.4 treated with 5 mM glutamate alone or with 5μM of EGCG as indicated (n = 3 independent experiments per condition; *P = 0.009; *P = 0.02) Quantification of Huh7 cell number co-cultured in transwell plates with the primary human macrophages treated with 5 mM glutamate alone as indicated (n = 3 independent experiments per condition; *P = 0.04; *P = 0.02) Quantification of human primary hepatocyte number co-cultured in transwell plates with the primary human macrophages treated with 5 mM and 5μM of EGCG (n = 4 and 3 independent experiments at 0 mM and 5 mM Two-ways ANOVA (p,q,r) and Mantel-Cox test (m) were used for statistical analysis Source data Potential HIF1α binding sites by scanning motif occurrences are identified in the Wnt3 promoter region Schematic representation of the location of the set of primers 1 (Wnt3_p1) and set of primers 2 (Wnt3_p2) on Wnt3 promoter region used for HIF1α ChIP-qPCR experiment in Raw 267.4 cells HIFα ChIP-qPCR using the set of primers 1 for Wnt3 in Raw 267.4 cells treated with 5 mM glutamate under hypoxia (n = 4; **P = 0.005) Ratios of liver-to-body weight (n = 3 per timepoint and group; *P = 0.05; *P = 0.04 from left to right of x axis) (o) and regenerated tissue (n = 3 per group; *P = 0.03; *P = 0.02) (p) of Uri1(+/Δ)Hep mice seven days after hepatectomy treated with BLZ945 and recombinant WNT3 ligand Quantification of IHC of Ki-67+ cells in livers from Uri1(+/Δ)Hep mice after hepatectomy treated with BLZ945 and recombinant WNT3 ligand (n = 3 per group; **P = 0.003; *P = 0.04) Ratio of liver-to-body weight (n = 3 per group) (r) and regenerated tissue (n = 3 per group) (s) of hURI1(+/KI)Hep mice seven days after hepatectomy treated with recombinant WNT3 ligand immediately post-hepatectomy Unpaired two-tailed Student’s t test and Two-ways ANOVA (q) were used for statistical analysis Source data Representative image of co-IF staining of GS+ and ECAD+ cells in livers of Ctnnb1(Δ/Δ)Hep mice crossed with Uri1(+/+)Hep or Uri1(+/Δ)Hep mice in livers of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 4 and 4) (b); hURI1(+/+)Hep and hURI1(+/KI)Hep mice WB of liver samples from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (d); hURI1(+/KI)Hep mice treated with recombinant Wnt3 ligand (e); Hif1α(+/+)Myeloid and Hif1α(+/Δ)Myeloid mice (f); Wnt3(+/+)Myeloid and Wnt3(+/Δ)Myeloid mice (g) Biochemical fractionation and WB analysis of liver samples from Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (h); hURI1(+/KI)Hep mice treated with recombinant WNT3 ligand (i); Hif1α(+/+)Myeloid and Hif1α(+/Δ)Myeloid mice (j); Wnt3(+/+)Myeloid and Wnt3(+/Δ)Myeloid mice (k) Relative mRNA levels of proliferative genes in isolated hepatocytes from livers of Uri1(+/+)Hep and Uri1 mice (n = 3 per group; *P = 0.05; *P = 0.02) in isolated hepatocytes from livers of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 5 in Nr1l2 Cdk1 and Foxm1 (Uri1(+/Δ)Hep); 3 in the remaining groups; **P = 0.01-0.0001) in isolated hepatocytes from livers of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 3 per group) o in isolated hepatocytes from livers of hURI1(+/+)Hep and hURI1(+/KI)Hep mice treated and non-treated with WNT3 recombinant protein (n = 3 (hURI1(+/+)Hep and hURI1(+/KI)Hep) and 4 (hURI1(+/KI)Hep mice treated with WNT3); **P = 0.003; ***P= 0.001; 0.001; *P = 0.02) in isolated hepatocytes from livers of hURI1(+/+)Hep and hURI1(+/KI)Hep mice treated and non-treated with WNT3 recombinant protein (n = 3 (hURI1(+/+)Hep) and Rapgef3 Cdk1 (hURI1(+/KI)Hep); 4 in the remaining groups; **P = 0.01-0.001) in isolated hepatocytes from livers of hURI1(+/+)Hep and hURI1(+/KI)Hep mice treated and non-treated with WNT3 recombinant protein (n = 3 per group) in mouse isolated hepatocytes from C57BL/6 mice cultured with glutamate (n = 3 (0- and 10-mM glutamate) and 4 (5 mM glutamate) in mouse isolated hepatocytes from C57BL/6 mice cultured with 5 mM glutamate (n = 3 (0 and 10 mM glutamate) and Nr1l2 Ccn1 (5 mM glutamate); 4 in the remaining groups) in isolated hepatocytes from livers of Uri1(+/Δ)Hep mice transplanted with bone marrow from Hif1α(+/+)Myeloid and Hif1α(+/Δ)Myeloid mice (n = 3 per group; *P = 0.02; *P = 0.05) in isolated hepatocytes from livers of Uri1(+/Δ)Hep mice transplanted with bone marrow from Hif1α(+/+)Myeloid and Hif1α(+/Δ)Myeloid mice (n = 3 per group; *P = 0.05-0.001) Representative image of co-IF staining of GS+ and ECAD+ cells in livers of Yap1(Δ/Δ)Hep mouse crossed with Uri1(+/+)Hep or Uri1(+/Δ)Hep mouse Scheme summarizing the keys findings of this study Source data Representative image of IF or IHC staining of URI1+ CSF-1R+ and Ki-67+ of livers from C57BL/6 mice at different timepoints of development WB analysis of livers from C57BL/6 mice at different timepoint of development using the indicated antibodies Ratios of liver-to-body weight (n = 3 per group; *P = 0.04) (c) and regenerative tissue (n = 3 per group; ***P < 0.0001) (d) of C57BL/6 mice seven days after hepatectomy treated with different glutamate concentrations Glutamate levels measured by NMR in livers of Glul(+/+)Hep Ratios of liver-to-body weight seven days after sham surgery or two-thirds hepatectomy (n = 5 5 from the left to the right of x axis; *P = 0.03; *P = 0.05; **P = 0.002 from left to the right) (f) and regenerative tissue (n = 6 (Glul(+/+)Hep) and 5 (Glul(Δ/Δ)Hep); *P = 0.02) (g) of Glul(+/+)Hep and Glul(Δ/Δ)Hep mice seven days after two-thirds hepatectomy Ammonia levels in plasma of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice after two weeks of tamoxifen treatment (n = 4 GSH levels measured by NMR in livers of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 5 (Uri1(+/+)Hep) and 6 (Uri1(+/Δ)Hep) GSH/GSSG ratio measured in isolated hepatocytes from livers of Uri1(+/+)Hep and Uri1(+/Δ)Hep mice (n = 3 per group) GSH/GSSG ratio measured in isolated hepatocytes from livers of Glul(+/+)Hep and Glul(Δ/Δ)Hep mice (n = 4 per group) GSH levels measured by NMR in livers of hURI1(+/+)Hep and hURI1(+/KI)Hep mice treated with glutamate with or without BLZ945 GSH/GSSG ratio measured in isolated hepatocytes from livers of hURI1(+/KI)Hep mice treated with glutamate with or without BLZ945 (n = 3 GSH/GSSG ratio measured in isolated hepatocytes from livers of C57BL/6 mice treated with increased glutamate concentrations GSH/GSSG ratio measured in cultured mouse isolated hepatocytes treated with 0- Haematoxylin and eosin (H&E) staining in different organs from C57BL/6 mice treated with 0 Creatinine levels in plasma of C57BL/6 mice treated with 0 Rotarod test in mice C57BL/6 mice treated with 0 Time taken to cross the tightrope test in C57BL/6 mice treated with 0 Quantification of Sirius Red staining in livers from Glul(+/+)Hep and Glul(Δ/Δ)Hep mice (n = 3 per group) Quantification of Sirius Red staining in livers from C57BL/6 mice treated with increased glutamate concentration Quantification of IF of CSF-1R+ cells in livers of Glul(+/+)Hep and Glul(Δ/Δ)Hep mice (n = 7 and 6; *P = 0.04) in livers of Glul(+/+)Hep and Glul(Δ/Δ)Hep mice (n = 3 per group; *P = 0.03) Quantification of IF of CSF-1R+ cells in livers of C57BL/6 mice treated with increased glutamate concentrations as indicated (n = 3 per group; ***P = 0.001) in livers of C57BL/6 mice treated with increased glutamate concentrations Unpaired two-tailed Student’s t test and ANOVA multiple comparison (c,d,n,x,y) test were used for statistical analysis Source data Unpaired two-tailed Student’s t test and Mantel-Cox test (c,e,p,s) were used for statistical analysis Source data a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law Download citation DOI: https://doi.org/10.1038/s41586-025-08778-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Findings reveal AI may reduce developer toil but its adoption introduces new complexities in workflows The report highlights AI's potential to significantly reduce developer burnout and improve productivity while also addressing the challenges organizations face in securely and effectively managing AI-generated code The survey of 500 engineering leaders and developers exposes a stark reality: on average organizations face $8 million in lost productivity per 250 developers annually with 78% of developers spending at least 30% of their time on manual repetitive tasks instead of delivering innovation Shadow AI raises governance and compliance alarms The potential of AI extends far beyond code generation.While AI in code generation dominates current investment priorities the report reveals an increasing focus on AI applications across the broader software development lifecycle (SDLC): Harness at the Forefront of AI in Software Delivery In September 2024, Harness introduced its multi-agent AI architecture designed to elevate the developer experience across the SDLC This architecture aligns with report findings addressing both productivity and governance challenges while improving deployment quality Harness's comprehensive software delivery platform is one of the only offerings in the market with built-in Open Policy Agent (OPA) support to ensure governance and security compliance This capability has become increasingly indispensable for organizations leveraging AI for code generation offering a critical layer of oversight to prevent vulnerabilities and enforce security standards across the SDLC "Developers today are under immense pressure to deliver faster and uphold quality—all while balancing an increasing cognitive load," said Jyoti Bansal "AI tools have the potential to dramatically reduce this burden by automating repetitive tasks and freeing developers to focus on creative problem-solving and innovation But let's be clear: AI is not a silver bullet these tools can inadvertently add to developer stress rather than alleviate it Striking this balance is essential—not only for productivity and quality but also for addressing the burnout crisis that continues to plague our industry." While 88% of engineering leaders and 90% of developers express concerns about AI replacing developers AI integration throughout the entire SDLC will create new roles and challenges for developers whose critical decision-making and contextual understanding are essential for software development and delivery Harness CEO Jyoti Bansal will be joined by industry leaders from OpenAI and others in a virtual event on January 8 from 10 AM to 12 PM PST to discuss the findings of the State of Software Delivery Report and the future role of AI in the SDLC More insights from the Harness State of Software Delivery report can be found here About Harness Harness is the leading AI-native platform for complete software delivery This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page It isn’t just about the reputations of the people named by the USTA it is also about the reputation of the SRIF itself that warrants a public airing: What did these people actually do What sort of evidence do you have against them What sort of investigative body are you really So there are some in the harness industry who are less sympathetic than others to Diamond Creek’s troubles Some believe that those on the list got off softly And there are some who are disappointed with the judgment of those who did business with Surick – the ones who made the list and the ones left off it – and with the lack of any public apologies or contrition once the USTA’s sanctions were announced.Whether that disappointment will manifest itself toward Diamond Creek at the yearling sales this fall or whether it is greater than the disappointment those targeted have expressed toward the USTA for its Surick investigation That’s because the USTA doesn’t come off shining brightly is on the sanctions list because she was the owner-of-record for the horses allegedly mixed up in this Another central question here is whether Nick was acting on his own behalf or on behalf of his mother Someone asked me last week: If the USTA was so concerned about the Suricks why was Debbie Surick still licensed by the USTA until June 2024 “The USTA and SRIF had reason to believe that Nick Surick remained active in the Standardbred industry despite his legal troubles and USTA membership lapsing in 2021,” an SRIF lawyer told me last week “We investigated whether this was true and our investigation determined that certain USTA members had ongoing relationships with Mr Surick involving registered Standardbreds and may have engaged in misconduct with Mr Surick in violation of the USTA’s Rules and Bylaws.” This misconduct did not involve horse doping or anything of that sort – on this everyone agrees.The investigation took place within the past 10 months or so the SRIF went to the USTA’s board and shared some findings The USTA then appointed a five-person “investigative committee” to review the evidence and make recommendations about sanctions The SRIF and the committee then reached out to the targets inviting them to participate in a hearing and sharing evidence with them the SRIF and the committee came to the USTA’s Board of Directors with its recommendations some were adopted at the annual meeting earlier this month Taylor’s criticisms of the SRIF and USTA here focused on the makeup and impartiality (or partiality) of that five-person committee that acted as a bridge between the SRIF and the USTA Taylor also forcefully criticized the process the SRIF and the USTA offered those who were accused I reached out to Taylor for comment but he declined the invitation.Diamond Creek’s chief Adam Bowden Bowden was fined $28,000 for his alleged role I reached out to him last week and he was blunt in his assessment of the SRIF investigation “What the USTA neglects to admit in all of this is that they have all these records of who owns what who is bred to which stallions and when,” Bowden told me The USTA on countless occasions refuse to give guidance when asked by our team regarding how to handle specific situations regarding breeding the mares in question We feel like we were railroaded by a dysfunctional investigation.” Later Bowden told me: “For eight months this has been a distraction and in my opinion the investigation of us has been a colossal waste of time and money.” By Andy Cohen is a three-time winner of the John Hervey Award for reporting on horse racing and a two-time winner of Canada’s Joe O’Brien Award for racing commentary See someone else’s good coverage of a racing integrity topic you want us to share Let us know via email at andrew@paulickreport.com has an 80 percent chance of rain on Kentucky Derby day Receive emails when new obituariesare published to our website Welcome to Meierhoffer Funeral Home & Crematory When you have experienced the loss of a loved one you can trust us to guide you through the arrangements necessary to create a meaningful ceremony that celebrates the unique life being honored Our staff is committed to providing your family with the highest quality care and service in your time of need and we take pride in our responsibility to lighten your burden as you take the first steps toward healing.  At Meierhoffer Funeral Home & Crematory we want to relieve you of the stress of funeral planning Whether you choose a full-service funeral or a budget-friendly direct cremation Funeral services can include a viewing or open-casket optional service Cremation services can be affordable and straightforward with a direct cremation without a service you can arrange cremation with a memorial ceremony our team can help you without the urgency of time You can plan ahead instead of forcing your family to make dozens of decisions regarding caskets when you choose our facility with an on-site crematory and a reception center your loved ones only have to make one stop Our Meierhoffer Funeral Home & Crematory team serves St. Joseph, Savannah, Avenue City, Agency, Clarksdale, Faucett Our permanent memorialization options will help you honor your loved ones in the way they would have wanted Meet with a member of our team at Meierhoffer Funeral Home & Crematory to tour the facility and get to know our staff. Visit our funeral home in Saint Joseph, MO, to see the beautiful facility and learn more about the services. You can call to ask any questions as well: (816) 232-3366 Click here to go to the Obituary page or Click the Obituary button above When finances are a concern we guarantee that we will take care of your family Permanent memorialization allows the healing process to begin We offer a full range of gifts to help comfort and support those who need it the most delivered direct from your local florist Our extensive collection of cremation urns and jewelry keepsakes is available on our online Urn Store For engraved or personalized options please contact one of our funeral directors for assistance Copyright © 2016 Meierhoffer Funeral Home & Crematory | Website Design by Frazer Consultants & TA Your browser may not work with certain site. Upgrade now. Both companies were founded by former AppDynamics founder Jyoti Bansal Harness announced Monday it is merging with API security startup Traceable combining two companies founded by former AppDynamics founder Jyoti Bansal The combined company is expected to generate more than $250 million in annual recurring revenue this year [Related: 10 Key Cybersecurity Startup Acquisitions In 2024: Q3-Q4] The merger “accelerates our march to reaching $1 billion in ARR as the consummate platform for software delivery,” he wrote in the post Harness, which offers what it calls an “AI-native” platform for software delivery, received a valuation of $3.7 billion in connection with its $230 million funding round in 2022. Traceable most recently raised $30 million at a reported valuation of $500 million in 2024, according to TechCrunch The companies were both launched out of Bansal’s startup San Francisco startup studio with Harness debuting in 2017 and Traceable launching in 2018 both of which have had Bansal as co-founder and CEO had followed the sale of AppDynamics to Cisco for $3.7 billion in March 2017 Combining Harness and Traceable will have major benefits for customers since “DevOps and application security are now seamlessly integrated into one platform” with the merger “The result is the new Harness: a first-of-its-kind platform that brings AI-native DevOps and security together to offer a streamlined end-to-end software delivery experience,” he wrote We recommend a front-clip no-pull harness when training a dog to walk on a leash without pulling It removes dangerous pressure from a dog's neck while reducing its ability to pull the best no-pull dog harnesses are designed to minimize pressure on a dog's neck and joints when they pull concluding that all types of dog collars can potentially harm a dog's neck A flat neck collar should only be used for attaching an identification tag or for decoration A body harness is a much safer and more effective option for walking a dog that pulls a veterinarian specializing in canine sports medicine and rehabilitation \"Dogs may pull on a leash due to hypersensitivity to all that is going on around them as well as a lack of proper leash training as a puppy,\" Baker says No dog is born innately understanding how to walk on a leash They pull because they naturally walk faster than we do and want to get to the park they keep pulling because they've learned that doing so allows them to move forward Choosing the best harness for your dog is like picking the perfect pair of running shoes: Fit is crucial There's nothing scarier than your dog wriggling or backing out of a loose-fitting harness An ill-fitting harness will also be uncomfortable A sagging harness can restrict a dog's full range of shoulder or leg movement A properly fitted harness will be snug but not too tight with enough room to fit two to three fingers under each strap Be sure to check the size chart and follow the instructions for measuring your dog measure carefully and check the return policy before placing your order no piece of equipment alone will teach them to stop but a good harness can help you control and manage your dog while working on leash manners If you continue walking whenever your dog pulls you not only miss the opportunity to train loose leash walking but also reinforce the pulling behavior a board-certified veterinary behaviorist and associate professor of clinical behavior medicine at the University of Pennsylvania School of Veterinary Medicine will not prevent the dog from pulling [and] will apply pressure on the neck.\" Head halters are a humane alternative to body harnesses and Baker recommends them for dogs that pull head halters may not be suitable for every dog Siracusa says they can cause whiplash or neck or spine pain if a dog is easily over-aroused or highly reactive on leash There is no such thing as a chew-proof harness A chewed-up harness is not a manufacturer defect or the result of poor design or materials A determined dog or teething puppy can easily destroy a harness in less than 30 seconds so always remove the harness when your dog is unsupervised take it off when dogs are roughhousing to prevent injury as their teeth and limbs can become entangled This article was medically reviewed by Sorin McKnight a veterinarian at Wellborn Road Veterinary Medical Center in College Station Dogs that pull on the leash can be a challenge to walk one of the best no-pull dog harnesses can help train your persistent puller to walk calmly on a loose leash These front-clip harnesses have a ring on the chest for attaching the leash which naturally pivots your dog toward you when they lunge forward This causes the leash to tighten slightly and redirects their movement Read more about how Business Insider Reviews tests and researches pet products were impressed by how much easier it was to walk untrained shelter dogs with this harness The dogs pulled less and were easier to control when the leash was attached to the front D-ring on the harness you can also attach the leash to the back of the harness for dogs that don't pull The Balance Harness is an excellent choice if you've struggled to find a well-fitting harness There are straps that clip around the torso and neck While the neck strap is ideal for dogs that resist putting their head through a harness this design can make it tricky to put it on The colored top strap on the back helps you easily identify the correct placement and the top strap of the all-black harness includes a printed logo for easy identification The soft nylon material meets a 3,500-pound test strength I toss mine into the washer and let it air-dry Read our full Blue-9 Balance Harness review the Ruffwear Front Range Harness is built to endure tough wear while ensuring your dog stays comfortable this is the only intact harness reporter Ren Volpe's dog still wears from his younger days The foam padding on the chest and belly prevents rubbing and chafing and the built-in clasps are covered with fabric so they don't touch any part of a dog's body "The padding is nice because it doesn't rub on my thin-coated dog," says Scarlett Cermak a professional dog trainer and owner of Embark Today "I also really like that there is a back-clip option because there are times The harness is easy to put on and take off It has two leash attachments: an aluminum V-ring on the back and a reinforced webbing loop on the chest plate the straps require frequent tightening as they loosen easily The harness has reflective stitching for nighttime visibility and its polyester shell fabric is extremely durable Although the brand recommends hand-washing the harness Volpe has put it in the washer and dryer numerous times but the edges have slightly curled over time The Petsafe 3-in-1 No-Pull Dog Harness allows you to attach the leash to the front to reduce pulling or secure it to the back ring for casual walks or runs with your dog it's also a great starting point if you're working with a tighter budget tested this harness with shelter dogs and was impressed with how well it worked for strong pullers "There's little chance a dog can wriggle out of this harness which is a big concern with shelter dogs," she says The Y-shaped nylon 3-in-1 doesn't restrict a dog's movement It features five adjustment points for a comfortable and the buckle at the neck eliminates the need to pull it over a dog's head The light neoprene padding and reflective stitching provide added comfort and safety this harness is heavier than similar styles While the wider straps help prevent chafing which may lead to discomfort during extended wear Petsafe recommends hand-washing the 3-in-1 which could make it challenging to remove odors The harness is easy to put on once you get the hang of it It includes a built-in adjustable strap to attach to a seat belt if you'd like to limit your dog's movement in the car it hasn't been crash-tested and may not protect your dog in an accident Pulling is mostly associated with large dogs a no-pull dog harness can help lessen pulling with pint-sized pups The Wild One Harness performed the best of the three harnesses reporter Alex Rennie tested with his 12-pound terrier mix When the leash was attached to the front D-ring the harness redirected his small dog each time he attempted to pull the harness remained secure and didn't shift when the dog lunged Rennie achieved the correct fit with three easy-to-use adjustment points each connected to a buckle (one at the neck and two at the back) The buckles could be fastened without lifting the harness over the dog's head — Ellis says this is a great feature for dogs who are uncomfortable with anything being placed over or around their head No matter how snug the harness was after adjustment thanks to extra padding around high-friction areas A layer of stretchy polyester covers the inside of the harness which reduces the possibility of discomfort and chafing the material sometimes caused the harness to shift on the dog even after adjusting the straps to get a perfect fit Wild One warns that some richer colors may bleed onto lighter-colored dogs the brand recommends handwashing the harness before first use Rennie washed the harness and found it dried quickly The PoyPet No-Pull Dog Harness is reporter Sophia Carlisle's favorite no-pull harness with a handle The versatile harness has several features that make walking a puller easier including an front leash attachment to prevent pulling The wide handle that runs horizontally across the back of the harness is especially useful when Carlisle needs to quickly grab her lunging dog Her 50-pound dog has a habit of rolling in burrs during forest walks and she frequently uses the handle to pull her away from spiky plants It can also be tough for Carlisle to see her black-coated dog during evening hikes since she blends in with the surrounding trees The reflective strips on this harness are a fantastic safety feature that makes it easy for other hikers and even people in cars to see her at any time of day The harness also has a locking buckle on the neck strap an excellent safety feature for dogs prone to bolting This feature kept Carlisle's dog secure in even when she was startled by a charging dog and tried to back out of the harness While the three separate attachment points eliminate the need to place the harness over your dog's head this design can make it confusing to put on at first The underside is reinforced with a webbed mesh material which helps the harness move with the dog but doesn't provide protection against chafing we recommend a more heavily padded harness The following considerations will help you choose the best harness to stop dog from pulling on leash Design: A dog harness should not impede or restrict movement and make sure the straps don't lay over the dog's front legs and shoulders Y-shaped no-pull harnesses are less likely to restrict movement than T-shaped harnesses harnesses with leash attachments on both the front and back offer more versatility regardless of the style of harness you choose If you can comfortably fit two fingers under the harness without being able to tug it forward it's likely to be both comfortable and secure for your dog Ease of use: A harness that's easy to put on and take off leaves less room for error Look for one with multiple adjustment points to ensure the best fit for your dog Padding: Extra padding provides comfort and helps prevent chafing and rubbing which is especially important for dogs that tend to pull Machine washable: A harness that's easy to clean will help prevent odors and look good for years to come Warranty: No-pull harnesses are a bit pricey so having the option to return or get a replacement for a defective one is a valuable perk We published this guide in 2020 after freelance reporter Shoshi Parks interviewed professional dog walkers and trainers to learn about their favorite no-pull dog harnesses She also consulted veterinarians and dog behaviorists to gather insights on what to look for in a harness freelance reporter Ren Volpe tested our top picks with untrained shelter dogs at Family Dog Rescue in San Francisco over an eight-week period Three shelter staff members and two volunteer shelter walkers used the harnesses during walks with more than two dozen medium and large rescue dogs all of whom were challenging to walk due to over-excitability The dogs were walked for 30 to 60 minutes on city streets and in local parks former reporting fellow Sophia Carlisle tested handle harnesses with her 50-pound pitbull mix while freelance reporter Alex Rennie tested small harnesses with his 12-pound terrier mix They both walked their dogs for at least 30 minutes on city streets and in local parks Here are the key factors we considered when evaluating the best no-pull dog harnesses Prevents pulling: We evaluated how effectively each harness prevented dogs from pulling on leash during walks We walked for a minimum of 30 minutes on 4-foot leashes Does not impede or restrict movement: We tested the harnesses on dogs of various sizes and shapes to ensure they didn't sag or have straps that obstructed the dog's front legs or shoulders The Petsafe Easy Walk and Wonder Walker harnesses were disqualified due to significant sagging during testing Does not chafe or rub: We tested harnesses on both long-haired and short-haired dogs to check for any chafing or rubbing Dog cannot slip or back out of the harness: This was a key factor in our testing as the shelter dogs we walked are more likely to be flight risks Easy to put on and take off/ease of adjustment: Putting on or adjusting a dog's harness should be simple Our shelter volunteers and testers recorded their experiences while fitting the harnesses on dogs Durability and washability: We asked professional dog walkers for their opinions on how well these harnesses hold up over time and after multiple washes Initial cost and replacement cost: We evaluated whether the harness's price is reasonable and how easily it can be replaced if it gets chewed "Dogs may pull on a leash due to hypersensitivity to all that is going on around them as well as a lack of proper leash training as a puppy," Baker says will not prevent the dog from pulling [and] will apply pressure on the neck." The combined company will move forward under the Harness name uniting software delivery and security into a single Jordan Smith recently announced they would merge to create an advanced AI-native DevSecOps platform the two companies will enable software teams to seamlessly develop co-founder and CTO at Traceable will be named GM of Harness’s application security business “This merger aims to address the challenges in balancing speed and security in software development by providing a truly unique offering in the marketplace,” said Nagaraj “Harness brings its unmatched visibility into the software development Traceable brings its deep insights into API usage and security platforms through its contextual analysis By merging this wealth of data together into a unified platform setting a new standard for teams to seamlessly develop and ensure security is built into every step of the software development lifecycle– from design to runtime.” Both organizations were developed at BIG Labs Harness’ mission was to simplify software delivery for software developers globally Traceable was established to secure the trillions of lines of code and millions of APIs that modern software runs on Traceable is rapidly growing into a complete application security platform “Harness and Traceable are coming together at a pivotal moment in the industry,” said Jyoti Bansal CEO and co-founder of both Harness and Traceable “Software teams should not have to choose between speed and security when delivering innovation to their customers setting a new standard for software delivery.” With both companies having similar origins they are uniquely positioned to be familiar with each other’s leadership structure and philosophy The shared origin gives both a strong foundation as the familiarity with one another should help them leverage the strengths of both companies more effectively The joint company seeks to set a new standard for teams to seamlessly develop and protect applications and ensure security is built into every step of the software development lifecycle cyber-resilient software delivery pipeline which is clearing the path for the next generation of DevSecOps platforms the first joint venture between the two companies will heavily focus on powering the next wave of AI-native process automation These agentic workflows will optimize and secure every stage of the software delivery process The companies want to help give organizations a competitive edge in an increasingly complex IT landscape “As a customer of both Harness and Traceable this merger is a game-changer for us,” said Jignesh Patel the director of cloud & DevOps at Morningstar “Having an integrated platform that seamlessly connects software development The combination of Harness and Traceable will provide the solution that enterprises and developers have been waiting for.” the merger means they can expect Harness and Traceable to deliver a software delivery platform that removes barriers to innovation and improves security across the SDLC Current customers can expect that the modules and features they use today will carry over into the future “Our dedication to innovation and execution remains stronger than ever,” said Nagaraj “We will also be investing significantly in tight integration between our DevOps and Application Security offerings and security engineers have a single platform for delivering secure software to customers this merger will strengthen our ability to serve new and existing customers with an end-to-end Harness and Traceable are working to build a library of AI-native agents to enhance software delivery’s speed and delivery process data from Harness and API-driven application usage and security patterns from Traceable This combined dataset will allow AI agents to optimize and secure every stage of the software delivery lifecycle while giving organizations a competitive advantage “Together, a unified Harness and Traceable change the game by offering something unique,” wrote Bansal in a blog post “Harness has peerless insight into how apps are built while Traceable brings deep knowledge of API usage and security Pooling and sharing that data on a unified platform creates a multiplier effect– taking AI-native the two companies say they’re committed to building a powerful library of AI agents that make software delivery faster this “first-of-its-kind platform that brings AI-native DevOps and security together to offer a streamlined end-to-end software delivery experience” means DevOps and application security are now seamlessly integrated into one platform for their customers “They’ll be able to get the best of both offerings improving the speed and efficiency of software delivery while ensuring that application security is built into every step of the development lifecycle this all adds up to a comprehensive software delivery platform that removes barriers to innovation and improves security across the SDLC.” Bansal says the key is that both companies share DNA and are rooted in the startup-within-a-startup model we’ve created innovative products by empowering small teams that are independent and accountable to benchmarks like performance “And both companies have enjoyed exceptional growth along the way The merged business brings substantial momentum With ARR north of $250 million projected this year– increasing more than 50 percent year-over-year– it’s one of the fastest-growing private companies of its size.” Early 2025 has been ripe with mergers and acquisitions to grow business and develop solutions to help customers drive revenue. Read more about some M&A news defining the channel in January Channel Insider combines news and technology recommendations to keep channel partners and SaaS providers informed on the changing IT landscape These resources provide product comparisons and interviews with subject matter experts to provide vendors with critical information for their operations Property of TechnologyAdvice.© 2025 TechnologyAdvice Advertiser Disclosure: Some of the products that appear on this site are from companies from which TechnologyAdvice receives compensation This compensation may impact how and where products appear on this site including TechnologyAdvice does not include all companies or all types of products available in the marketplace The company's most ambitious update to date introduces a library of AI assistants for DevOps coupled with powerful updates designed to optimize the entire software development lifecycle The highlight of this release is a multi-agent AI architecture designed to revolutionize workflows and enhance the work experience for software developers globally Harness is redefining its approach to AI by embedding it into the core of its platform creating a dynamic ecosystem of AI-driven "assistants" that streamline every facet of software delivery and empower developers to focus on what they do best: building innovative software The initial rollout includes specialized AI solutions for DevOps "DevOps teams today are overwhelmed by repetitive time-consuming tasks that pull them away from their true purpose—innovation," said Jyoti Bansal we believe AI is not just an enhancement but an essential fabric of modern software development These AI-powered tools are more than just productivity boosters—they are virtual expert collaborators embedded into every stage of the development process By weaving AI deeper into the core of our platform we're enabling engineers to transcend routine tasks and push the boundaries of what's possible in software delivery This is the future of development: developers working hand-in-hand with AI to achieve more Harness introduced several new modules and enhancements to its existing platform: For more information about Harness, please visit https://www.harness.io Artificial Intelligence Dog harnesses are sometimes claimed to reduce pulling forces on the leash but an experiment found they have the opposite effect By Christa Lesté-Lasserre Dogs wearing harnesses can pull with a force exceeding their body weight Dogs generally pull about 60 per cent harder on a leash when wearing a padded harness compared with a collar even when the equipment is marketed as “anti pull” – putting the people walking them at risk of injury Some dogs – especially smaller breeds – pull with a force more than twice their body weight on the collar, potentially damaging their throats, says Erin Perry at Southern Illinois University Read more How a unique puppy kindergarten lab put the science into dog training “It’s really very shocking,” she says.… Official website of the State of California What you need to know: Governor Gavin Newsom invites developers to help create Generative AI (GenAI) solutions for some of the most challenging issues facing California and its 39 million residents “As the birthplace of the tech industry and the fifth largest economy in the world We’ll deploy every tool to address some of the most vexing issues of our time including the housing and homelessness crisis California has the technology and the innovative spirit — let’s put them to use for the public good.” California is leading the way in the adoption and development of GenAI technologies and California will play a pivotal role in defining that future and academia – to discuss how the state can best use this transformative technology to better serve the people of California California is home to 32 of the world’s 50 leading GenAI companies high-impact research and education institutions and a quarter of the technology’s patents and conference papers State agencies and departments began analyzing potential uses for GenAI and developed critical challenges within state government particularly focusing on issues that impact vulnerable populations the Governor announces the first step in the process to potentially adopt GenAI to address the following issues identified by state agencies: “The innovator community jumped at the chance to partner with the state to explore if GenAI can benefit our residents and our workforce,” said Government Operations Agency Secretary Amy Tong shows us that we can embrace GenAI’s many opportunities while taking appropriate measures to approach it safely and responsibly.” the state will host developers of large language models (LLMs) to present demonstrations of the most current functional capabilities of their GenAI tools related to these challenge statements This is not a formal procurement process but market research often used by the state to identify what’s currently in the marketplace Housing and Homelessness, Press Releases, Recent News News What you need to know: The Governor honored the contributions of fallen California law enforcement officers at the annual California Peace Officers’ Memorial Ceremony California – Honoring the contributions of fallen California peace officers,.. News What you need to know: California applied to the federal government today to update the state's benchmark plan which would expand coverage requirements for essential health benefits (EHBs) like hearing aids and wheelchairs in the individual and small group.. News What you need to know: California remains the #1 state for tourism with record-high tourism spending reaching $157.3 billion in 2024 the Trump administration’s policies and rhetoric are driving away tourists © Copyright document.write(new Date().getFullYear()) and how to harness the technology in every day work and life Artificial intelligence is everywhere right now but if you’re struggling to understand the difference between ChatGPT or simply want to learn how to better use the technology Duke’s Office of Information Technology is offering series of free workshops this fall to help OIT’s LearnIT@Lunch is a series of online information sessions designed to help all Duke students staff and faculty learn more about technology in a relaxed environment from 12-1 p.m and how to harness the technology in your every day work and life and we are eager to capture the Duke community's interest and provide information on how to use these tools safely essentially creating an AI-literate community,” said Trina Rodriguez “This is your chance to learn directly from Duke experts and tap into professional development resources You can catch a single session or attend them all.” The full list of sessions is below, and updated class descriptions can be found here Zoom Link: https://duke.is/c/vqry OIT’s Media Architect and Senior Producer for Academic Media Production to discover how AI is transforming the workplace in "Practical Applications of AI: Mind Meets Machine: Using ChatGPT4o In The Real World." This talk will explore how to leverage ChatGPT4o to enhance daily office tasks from summarizing complex data to providing real-time technical support — all while ensuring data security actionable strategies to seamlessly integrate AI into your workflow Zoom Link: https://duke.is/b/dcj8 Join Alpha Esser in "Getting Cozy with AI: Beginners Guide to Microsoft Copilot." The course is designed for anyone who wants to learn how to use Bing’s Copilot (powered by OpenAI's GPT-4) This powerful and creative chat assistant can help you with various tasks while protecting the data and business interests of Duke University you will learn how to interact with Copilot and receive tips to make the most of Copilot’s features and capabilities Zoom Link: https://duke.is/n/kpu8 Join Felipe Polo-Wood on an insightful journey into the world of AI and Large Language Models (LLMs) where technology meets real-world applications In "Beyond Algorithms: Bridging Technology and Everyday Needs," explore how cutting-edge AI solutions are being developed and used to address practical challenges — from simplifying daily tasks and enhancing personal projects to transforming education and digital experiences Discover the paradigm shifts from traditional computing to generative AI learn when to leverage these powerful tools and see how advanced technology can be harnessed for everyday use This talk is perfect for anyone curious about the real impact of AI on our lives and eager to discover the creative potential of these technologies in action Zoom Link: https://duke.is/b/ffkz Zoom Link: https://duke.is/4/gcpg Zoom Link: https://duke.is/4/2p7c Zoom Link: https://duke.is/5/p2ew Join Mark McCahill as he describes how advances in AI language models are making it feasible to search summarize and extract meaningful information from unstructured / semi-structured text and documents. New AI capabilities can augment how we handle and process information that does not fit well into tabular formats like spreadsheets or relational databases – for example This presentation will cover how Semantic Search, Knowledge Graphs and  Retrieval Augmented Generation (RAG) technology can extend the capabilities of Large Language Models (LLMs) such as ChatGPT by reducing LLM's tendency to "hallucinate" incorrect information The session will also discuss some potential applications of these AI technologies at Duke Send story ideas, shout-outs and photographs through our story idea form or write working@duke.edu Follow Working@Duke on X (Twitter), Facebook and Instagram and subscribe on YouTube Duke Today is produced jointly by University Communications and Marketing and the Office of Communication Services (OCS) Articles are produced by staff and faculty across the university and health system to comprise a one-stop-shop for news from around Duke Geoffrey Mock of University Communications is the editor of the 'News' edition Leanora Minai of OCS is the editor of the 'Working@Duke' edition The harness racing world is mourning the loss of a Chagrin Falls native who died after a racing accident this week Hunter Myers, 27, passed away Thursday after sustaining injuries during a race at Hollywood Casino at The Meadows in Washington, Pennsylvania, according to a press release from the U.S are deeply saddened by this tragic event,” Hollywood Casino at The Meadows and the Meadows Standardbred Owners Association said in a joint statement “Our thoughts and sympathy are with his fiancée Myers first began his driving career as a 16-year-old the latest in a long line of harness racing He earned his first win with a horse trained by his dad on July 11 He would go on to win 298 races over the next four years before earning his first $1 million season in 2019 finishing in the winner’s circle 164 times Myers won 2,450 races and $21.7 million in purses during his career and was a three-time finalist for the U.S Harness Writers Association’s Rising Star Award remarkable part of the fabric of the sport and he died doing what he loved," USTA wrote in a statement generous friend to the legions in American harness racing who knew him." MGM Northfield Park, in conjunction with the Ohio Harness Horsemen's Association, will honor Myers on Sunday before the first race, according to a Facebook post and the first race will be held in silence to commemorate Myers Northfield Park’s Iron Maiden Series will also be re-named the Hunter Myers Memorial Series in memory A GoFundMe page was created in his honor to support his fiancée and son In harness racing, drivers steer a two-wheeled cart known as a "racebike" that is pulled by Standardbred horses, according to USTA Standardbreds weigh between 800 and 1,200 pounds and are known to be athletic and intelligent they typically serve as police or military mounts as well as trail-riding companions Reporter Anthony Thompson can be reached at ajthompson@gannett.com There is a lot to love about Ruffwear's Front Range dog harness it comes from a brand that's beloved by dog owners around the world It also has a durable yet lightweight and breathable construction consisting of ripstop polyester two attachment points (one on the back and one on the front with the latter perfect for leash-reactive pups) four adjustment points for the perfect fit and rear-mounted clips that don't get mucked up quite as bad as belly-clipped competitors you've got one of the most formidable all-around options available perhaps ever If your dog needs one solid harness for all your activities (and you don't mind the relatively high price point) while the price of this harness was quite high it more than made up for the cost in its range of tremendous features that allow for versatility Every product is carefully selected by our editors. If you buy from a link, we may earn a commission. Learn more Ruffwear has grown to be ubiquitous anywhere dogs and the outdoors intersect thanks especially to the brand’s legendary adventure harnesses Kruse had no intention of building a dog company.  An avid whitewater kayaker, Kruse initially set out to build an outdoor adventure brand for people always bringing his dog along for the ride he quickly realized: there was a serious lack of well-made outdoor gear for dogs “This was never a business in the making it was a series of products being created to solve problems.” it was a series of products being created to solve problems,” Kruse says was born in the off-season when his friends needed a better way to keep their dogs hydrated on mountain biking trips “You could almost see the light bulbs go on over their heads.” Adventure’s Best Friend: This article is part of a series of stories and gear reviews about adventuring with dogs. Want more? Check out the complete collection It wasn’t long before a retailer in Colorado approached him with an idea: dog boots pointing to six different boots in a catalog After the boots and bowls came an early prototype of the Palisades Dog Backpack designed with a handle to help owners lift their dogs over obstacles in the backcountry But the real game-changer was when an employee’s husband — a ski patroller — started using the pack’s harness how do we take what we’ve learned and just make a standalone harness?” Kruse says a robust three-strap style harness still in production It has since become a go-to for countless avalanche rescue teams service dog handlers and general adventurists pretty much everywhere and the Ruffwear founder wanted a harness more streamlined than the Web Master — something that fit a dog like a t-shirt “If you’re just going out the front door for a quick walk you might not need a handle to lift your dog over an obstacle,” Kruse explains So we took our Web Master Harness and chopped the back third off it.” streamlined version became Ruffwear’s now legendary Front Range Dog Harness It sold over a million units in just two years it feels like Ruffwear scaled naturally alongside the adventures he was already on.  He still lives life on the move — hang gliding motorcycling — and constantly draws inspiration from different outdoor disciplines in a world where dogs have increasingly become our companions across all aspects of life Patrick is constantly on the lookout for the next challenge “The problems we’re solving aren’t just from ten years ago They’re the ones adventurers are facing today.” “The problems we’re solving aren’t just from ten years ago,” he says “They’re the ones adventurers are facing today.” what’s in the hopper at Ruffwear these days “It’s designed so a dog can hang out by the campfire get up in the middle of the night if they need to the San Juan Islands and Baja; she evene recently towed a fishing boat from Bend “As people continue to push the envelope and test the boundaries “That’s what Ruffwear does,” Kruse says “We build products that let you go farther with your dog.” Please enable JS and disable any ad blocker Jane Palmer is a freelance journalist in Colorado doi: https://doi.org/10.1038/d41586-024-02762-2 These interviews have been edited for length and clarity. How I honed my biopharma dealmaking and business-development skills after my PhD Can Germany rein in its academic bullying problem? Want to supercharge your science? Turn to technicians Walking in two worlds: how an Indigenous computer scientist is using AI to preserve threatened languages The use of AI in peer review could undermine science Science sleuths flag hundreds of papers that use AI without disclosing it Cuts to US science will take a generation to repair — leaders must speak up now In science-for-policy design, one size doesn’t fit all POST-DOCTORAL RESEARCH FELLOW Post Summary of the role The Characterisation & Processing of Advanced Materials. Prof. Valeria Nicolosi research group. HT is an interdisciplinary research institute, created and supported by the Italian government, whose aim is to develop innovative strategies to pr... UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, ... Department of Energy and Environmental Materials, Suzhou Laboratory Lead bold science at ONJCRI. Shape strategy, drive impact, and advance cancer research in a leading translational institute. Olivia Newton-John Cancer Research Institute An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Many corporate CEOs are unhappy with the level of innovation they’re getting for the billions they pour into R&D lies in the managerial tendency to treat novel ideas as aberrations to be resisted At each stage of the innovation process—from inception to integration to implementation—executives will either water down “deviant” ideas to make them fit within existing businesses or crush them altogether Copyright ©2025 Harvard Business School Publishing Harvard Business Publishing is an affiliate of Harvard Business School either observed and verified firsthand by the reporter or reported and verified from knowledgeable sources Translations may contain inaccuracies—please refer to the original content A cat owner has shared why it's time to start harness training your cat, and the compilation video has racked up over 1 million views on TikTok The "pawrent" of Atlas (@atlasthetuxedo), a 9-month-old tuxedo kitten, decided to harness train him since they live on a busy road where a lot of unleashed dogs roam "I wouldn't change my decision for anything He absolutely loves car rides and will stick his head out of the window like a dog He totally thrives outdoors with his harness on," the owner told Newsweek The video shows Atlas having the time of his life on his leash running across the beach and climbing trees The text overlaid on the clip says: "This is your sign that harness training IS worth it." The video has received 1.2 million views and 125,600 likes so far said that harness training can be an excellent way to enrich your cat's life while keeping it safe She told Newsweek: "Outdoor experiences provide stimulation that helps reduce boredom and stress in indoor cats. A harness allows your cat to safely experience the outdoors without the risks of free roaming Walking your cat strengthens the bond between you and your pet Cats who get more physical activity outdoors may have an easier time maintaining a healthy weight." Vasudevan cautions that not all cats will enjoy harness training She said that some cats may dislike the harness or feel stressed outdoors Training a cat to accept a harness and leash outdoor exposure could pose risks from fleas Vasudevan recommends selecting a well-fitting, adjustable harness designed for cats. She advises owners to allow their cat to sniff and explore the harness indoors before putting it on. Also, put the harness on the cat indoors for a few minutes at a time She also suggests attaching the leash indoors and letting the cat drag it to get accustomed to the feel "Harness training is one of the safest ways to let your cat enjoy the outdoors as it minimizes risks associated with free roaming alternatives like building a catio or supervised time in a fenced yard can also work well particularly for cats who resist harness training the best option depends on the cat's temperament and the owner's environment," Vasudevan said with many curious about how they could harness train their cats I've tried with all my cats but they're just traumatised and won't move," asked one viewer "My cat won't listen and go on walks with me when outside I just couldn't keep her indoors all the time I also put an AirTag on it just in case," shared another viewer Do you have funny and adorable videos or pictures of your pet you want to share Send them to life@newsweek.com and they could appear on our site Newsweek is committed to challenging conventional wisdom and finding connections in the search for common ground Newsweek is committed to journalism that is factual and fair We value your input and encourage you to rate this article Newsletters in your inbox See all The horse racing world is mourning the loss of an accomplished harness driver after a racing accident earlier this month Hunter Myers, 27, passed away from injuries he sustained during a race March 19 at Hollywood Casino at The Meadows in Washington, Pennsylvania, according to the U.S. Trotting Association Myers was thrown from his horse-drawn cart in a chain-reaction crash involving five horses that began when the lead horse made a sudden break Myers' driving career began in 2014 at age 16 and his family's involvement in harness racing spans generations with his father his dad's grandfather and uncle all being a part of the sport He won his first race with a horse trained by his dad on July 11 adding that he would go on to win 298 races over the next four years before earning his first $1 million season in 2019 and finishing in the winner’s circle 164 times A GoFundMe page to support his fiancée and son said his "friends and family will always remember his smile the page had logged more than $80,000 in donations "Hunter was a proud father and absolutely adored his son The seven short months they spent together created an everlasting bond," the organizer wrote "He was over the moon in love with his fiancé Chloe and was ecstatic about their upcoming wedding." In harness racing, drivers steer a two-wheeled cart known as a "racebike" that is pulled by standardbred horses, according to USTA Black Diamond Equipment issued a recall today for its Vision harness due to “premature degradation of its specialized materials and construction.” The Vision harness in Black Diamond’s recall uses Vectran fibers in the waist belt It helps make the Vision one of the lightest However, the recall notice also lists the “specialized materials and construction” as the cause of one reported failure Black Diamond reports that a “heavily used product in which the waist belt failed in an atypical manner with no reported injuries or fatalities.” The Salt Lake City brand states that it is still searching for the root cause but issued the recall out of “an abundance of caution.” The recall affects all Vision harnesses sold between Jan Black Diamond states that owners of an affected Vision harness should immediately stop using it. It instructs owners to send it back to the brand, free of charge, by filling out a recall form Black Diamond offers two financial remedies: If you have any questions regarding this recall, contact Black Diamond at 1-866-306-0865 (Mon. through Fri., 9 a.m. to 4 p.m. MT) or send an email to the Vision Harness Recall address We found the best climbing harnesses of 2025 Whether you're sport climbing or mountaineering and the gear and training for those pursuits Ishii has trained elite and professional endurance Ishii was a freelance contributor to print and web publications related to his interests and professional experiences He continues to pursue climbing and cycling objectives seriously New AI model identifies possible therapies from existing medicines for thousands of diseases including rare ones with no current treatments The AI tool generates new insights on its own applies them to conditions it was not trained for and offers explanations for its predictions AI can expedite the development of more precise treatments with fewer side effects at far lower cost than traditional drug discovery There are more than 7,000 rare and undiagnosed diseases globally Although each condition occurs in a small number of individuals, collectively these diseases exert a staggering human and economic toll because they affect some 300 million people worldwide. with a mere 5 to 7 percent of these conditions having an FDA-approved drug they remain largely untreated or undertreated Get more HM news here Developing new medicines represents a daunting challenge but a new artificial intelligence tool can propel the discovery of new therapies from existing medicines offering hope for patients with rare and neglected conditions and for the clinicians who treat them is the first one developed specifically to identify drug candidates for rare diseases and conditions with no treatments It identified drug candidates from existing medicines for more than 17,000 diseases many of them without any existing treatments This represents the largest number of diseases that any single AI model can handle to date The researchers note that the model could be applied to even more diseases beyond the 17,000 it worked on in the initial experiments The work, described Sept. 25 in Nature Medicine, was led by scientists at Harvard Medical School. The researchers have made the tool available for free and want to encourage clinician-scientists to use it in their search for new therapies especially for conditions with no or with limited treatment options “With this tool we aim to identify new therapies across the disease spectrum but when it comes to rare, ultrarare, and neglected conditions, we foresee this model could help close, or at least narrow, a gap that creates serious health disparities,” said lead researcher Marinka Zitnik, assistant professor of biomedical informatics in the Blavatnik Institute at HMS “This is precisely where we see the promise of AI in reducing the global disease burden, in finding new uses for existing drugs, which is also a faster and more cost-effective way to develop therapies than designing new drugs from scratch,” added Zitnik, who is an associate faculty member at the Kempner Institute for the Study of Natural and Artificial Intelligence at Harvard University. The new tool has two central features — one that identifies treatment candidates along with possible side effects and another one that explains the rationale for the decision. In total, the tool identified drug candidates from nearly 8,000 medicines (both FDA-approved medicines and experimental ones now in clinical trials) for 17,080 diseases, including conditions with no available treatments. It also predicted which drugs would have side effects and contraindications for specific conditions — something that the current drug discovery approach identifies mostly by trial and error during early clinical trials focused on safety. Compared against the leading AI models for drug repurposing, the new tool was nearly 50 percent better, on average, at identifying drug candidates. It was also 35 percent more accurate in predicting what drugs would have contraindications. Repurposing existing drugs is an alluring way to develop new treatments because it relies on medicines that have been studied, have well-understood safety profiles, and have gone through the regulatory approval process. This approach to drug repurposing is haphazard at best. It relies on patient reports of unexpected beneficial side effects or on physicians’ intuition about whether to use a drug for a condition that it was not intended for, a practice known as off-label use. “We’ve tended to rely on luck and serendipity rather than on strategy, which limits drug discovery to diseases for which drugs already exist,” Zitnik said. The benefits of drug repurposing extend beyond diseases without treatments, Zitnik noted. “Even for more common diseases with approved treatments, new drugs could offer alternatives with fewer side effects or replace drugs that are ineffective for certain patients,” she said. This capacity, the research team said, brings the AI tool closer to the type of a reasoning a human clinician might use to generate novel ideas if they had access to all the preexisting knowledge and raw data that the AI model does but that the human brain cannot possibly access or store. The tool was trained on vast amounts of data, including DNA information, cell signaling, levels of gene activity, clinical notes, and more. The researchers tested and refined the model by asking it to perform various tasks. Finally, the tool’s performance was validated on 1.2 million patient records and asked to identify drug candidates for various diseases. The researchers also asked the tool to predict what patient characteristics would render the identified drug candidates contraindicated for certain patient populations. Another task involved asking the tool to identify existing small molecules that might effectively block the activity of certain proteins implicated in disease-causing pathways and processes. In a test designed to gauge the model’s ability to reason as a human clinician might, the researchers prompted the model to find drugs for three rare conditions it had not seen as part of its training — a neurodevelopmental disorder, a connective-tissue disease, and a rare genetic condition that causes water imbalance. The researchers then compared the model’s recommendations for drug therapy against current medical knowledge about how the suggested drugs work. In every example, the tool’s recommendations aligned with current medical knowledge. Moreover, the model not only identified medicines for all three diseases but also provided the rationale behind its decision. This explainer feature allows for transparency and can increase physician confidence. The researchers caution that any therapies identified by the model would require additional evaluation for dosing and timing of delivery. But, they add, with this unprecedented capacity, the new AI model would expedite drug repurposing in a manner not possible until now. The team is already collaborating with several rare disease foundations to help identify possible treatments. View this post on Instagram A post shared by Harvard Medical School (@harvardmed) and Nils Gehlenborg.This work was supported by National Science Foundation CAREER award (grant 2339524) National Institutes of Health (grant R01-HD108794) Department of Defense (grant FA8702-15-D-0001) Roche Alliance with Distinguished Scientists Biswas Family Foundation Transformative Computational Biology Grant in partnership with the Milken Institute HMS Dean’s Innovation Awards for the Use of Artificial Intelligence Kempner Institute for the Study of Natural and Artificial Intelligence at Harvard University Churchill Summer Institute in Biomedical Informatics at HMS Awards aim to accelerate translation of discoveries made at Harvard Medical School into new.. showed signs of improved vision in animals and organoids predict survival for multiple cancer types Studies detailing brain-immune crosstalk could inform treatments for autism Scientists weigh in on the spread of H5N1 and highlight clues that portend what might come next Researchers recognized for accomplishments in biological sciences © 2025 by The President and Fellows of Harvard College