The in vitro biological oxidation of albendazole to its pharmacologically active sulfoxide and its sulfone by ovine liver microsomes has been studied Sulfoxidation (maximal rate = 0.412 nmole/min/mg of protein Michaelis constant = 185 × 10−6 M) was 107 times more potent than formation of albendazole sulfone The sulfoxidation corresponds to a reduced nicotinamide-adenine dinucleotide phosphate-dependent enzymatic system characterized by a pH optima value around 8 Flavin adenine dinucleotide-containing monooxygenase could be responsible for this S-oxygenation because of the strong inhibitory effect of methimazole Albendazole sulfoxidase is inhibited competitively by the related anthelmintic drug fenbendazole (inhibitory constant = 243 × 10−6M) and noncompetitively by chlorpromazine (inhibitory constant = 135 × 10−6M) and hexobarbital are less active inhibitors whereas dexamethasone acetate significantly enhances the reaction which is not inhibited by either carbon monoxide Subscribe to newsletters © 2025 American Veterinary Medical Association. 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Powered by KGL PubFactory A French homeless man who built his own intricate castle out of recycled foam after losing his apartment has been notified by authorities to tear it down because it poses a danger a 53-year-old former animator from Toulouse after reportedly losing his apartment to squatting he had no choice but to sleep in a tent on the outskirts of Tournefeuille an old woman stopped in front of his tent and said “that’s not very clean,” so he decided to upgrade his temporary abode to something more visually appealing he steadily built himself a fairytale castle out of recycled and painted blocks of foam found in dumpsters his home became a popular attraction for both children and adults Apart from constantly improving his foam castle by adding all kinds of accessories David also hosts creative workshops for children on a voluntary basis every Sunday He never bothered anyone and locals seem to love his beautiful castle Some were shocked to learn he uses it as a home thinking that it was an artistic installation paid for by the local council Although everyone seems to be in awe of David’s talent local authorities aren’t as impressed they sent the homeless person a rather inappropriate gift a letter notifying him that he needed to dismantle his castle as soon as possible The backlash from the locals has convinced officials to extend David’s deadline but they insist that the man’s home will have to be destroyed “It’s made of foam, so if it catches fire the person inside could die and the fire could spread,” a spokesperson for the Tournefeuille town hall said adding that it was the mayor’s responsibility to ensure the safety of the town’s citizens locals believe that authorities should come up with another solution in order to preserve David’s “magical castle” which children have grown to love so much Here is more information about os Lobos No 7 Portugal's flanker Nicolas Martins (Getty Images) Portugal keeps surprising the Rugby World Cup fans and between the elusive Raffaele Storti the loose forward who hasn’t missed one tackle in two games Let’s find out more about the flanker who scored Portugal’s first try in the 2023 RWC He is the son of José Martins and Patricia Holfelt and qualifies as a Portuguese-French international He was born in Toulouse on the 18th of January 1999 Martins started playing rugby at the age of seven Judo and basketball were his two other sports while growing up he was tested at the wing but quickly settled as a flanker and lock thanks to his height and strong build One is rocking at the wing for Blagnac (Nationale) while the youngest of the Martins family is still a junior for Tournefeuille His rugby idols are Thierry Dusautoir and Richie McCaw both loose forwards whome he views as the best ever to play the game he studied Aeronautic engineering under the Airbus wing while playing for Tournefeuille and Castanet He would end up giving it all up to become a pro rugby player His first cap for Portugal was just one year ago playing the last ten minutes in a Summer International against Georgia in Tbilisi He was the hero for SA XV Charente when in the dying minutes of their final match in the ProD2 2022-2023 season he scored a try picking up a losing bonus point that saved them from relegation to the Nationale he didn’t miss a single tackle out of 54 and was the only player with a 100% accuracy rate He was swept up in the emotion of singing the national anthem in front of 30,000 people in Nice for Portugal’s first match in the 2023 Rugby World Cup He said: “I’m not a stressed man before and during the anthem Download the digital edition of Rugby World straight to your tablet or subscribe to the print edition to get the magazine delivered to your door Follow Rugby World on Facebook, Instagram and Twitter/X so who better to front a new look than England’s man… A FAIRYTALE castle built by a homeless man is set to be torn down by a killjoy council - despite locals thinking it's "magical" constructed the bizarre makeshift home - known as the Hobbit House - from rubbish and recycled foam found at a tip David's unique home has now become a popular spot in the local area in Tournefeuille, near Toulouse in France Not only has his castle become a tourist attraction but he also uses it to run art workshops for children who was forced out of his old apartment by squatters initially lived in a battered tent beside the nearby Touch River He then decided to upgrade his home and build himself a fairytale castle in the woods To his surprise, his two-metre high DIY castle quickly became a local tourist attraction for both children and adults. David then started hosting workshops for kids every Sunday where they gathered at the castle to make toys. Local Souhail Amirouch, 28, said: "I think it's a great curiosity and inspires the imagination. who takes his six-year-old daughter to the Hobbit House added: "You have to wonder why they are doing it because at the end of the day doesn't bother anyone Some were shocked to learn David uses it as a home - thinking the impressive structure it was an art installation paid for by the council But now David is facing homelessness again after councillors ordered him on Christmas Eve to tear down the castle David said: "The fact that I'm here is obviously illegal but the way they are trying to get me to move on is not being done in legal way with a full notice and therefore it has at the moment no more value than a wish." The council claims the structure - made out of foam blocks - is a fire risk and could also encourage other DIY builders to put up buildings in the woods The mayor's office said they have responsibility for the safety of the town and its people the deadline for it to be dismantled has now been extended - but the council said it will not be put off Our journalists strive for accuracy but on occasion we make mistakes. For further details of our complaints policy and to make a complaint please click this link: thesun.co.uk/editorial-complaints/ Arnaud Mourier OKSi vous êtes un être humain un minimum censé vous avez forcément déjà souhaité la fin définitive Tout le monde déteste ces petits enfoirés dont le seul but dans leurs ridicules et très courtes vies est de nous empêcher de dormir et de nous faire nous gratter par la suite après une nuit qui aura duré tout au plus quatre heures.. la ville de Colomiers va mettre en place une borne qui sera testée pour venir à bout du moustique tigre (sans doute le boss final des moustiques) à qui on a d'ailleurs donné un nom beaucoup trop classe pour ce qu'il est réellement est en train de faire son retour dans le coin et devant l'ampleur de ce qui nous attend les communes de l'agglomération toulousaine comptent bien lancer une contre-attaque La première étape aura lieu jeudi et verra Blagnac Tournefeuille et donc Colomiers organiser une réunion publique sur les bonnes pratiques à adopter pour les habitants C'est ce même jour que Colomiers va lancer une expérience qui pourrait bien changer nos nuits estivales futures durant un mois (dans un premier temps) une borne anti-moustique va être installée Celle-ci diffuse des molécules de CO2 de façon saccadée pour reproduire la respiration humaine ainsi qu'un leurre olfactif Le moustique croit donc qu'il va piquer un humain (quel idiot...) mais se retrouve en réalité aspiré par une cheminée puis stocké dans un filet Le rayon d'action de la borne allant de 30 à 60 mètres Bien évidemment on n'en est qu'aux débuts et c'est dans un mois qu'un premier bilan sera effectué l'expérimentation pourrait devenir la norme avait testé le procédé en 2016 capturant ainsi 300.000 moustiques et évitant par là même la ponte d'un milliard d'oeufs.. Auriane © FlickrOKBILLET D'HUMEUR Nous venons d'apprendre de la bouche de notre collègue toulousaine que la Compagnie La Machine allait s'installer à Toulouse et y présenter ses machines la colère (un peu) et la possessivité écrit comme une réaction à vif De nouveaux éclairages formels devront y être apportés car nous n'avons pour l'instant pas la confirmation de l'existence de ce projet par la Compagnie La Machine elle-même Quand ma collègue du Bonbon Toulouse m'a gentiment demandé : "dis c'est quoi exactement l'éléphant de Nantes ?" La honte..." et le lui avoir expliqué je lui ai demandé ce que ça pouvait bien lui faire pourquoi elle posait cette question.. Sa réponse : "on va avoir la même chose à Toulouse : la Piste des géants."  Je dois avouer (avant tout) que je n'étais même pas au courant que la Compagnie La Machine avait un atelier à Tournefeuille Je me suis donc écriée : "mais c'est un SCANDALE Comment peuvent-ils nous faire ça ?" Il est toujours aussi impressionnant, ce grand éléphant des #machinesdelile #nantes #igersnantes #nantesjetaime Une photo publiée par Le Bonbon Nantes (@le_bonbon_nantes) le 22 Sept La Compagnie La Machine a connu ses premiers succès à Nantes auxquels sont associés la Compagnie ET les Machines de l'Île ce sentiment d'ancrage à Nantes était renforcé D'autant que la compagnie est très soutenue par la ville de Nantes et la région Pays de la Loire.  Bon mercredi les bonbons ! Avez-vous prévu un petit tour à la galerie des machines prochainement ? #nantes #igersnantes #machinesdelile #nantesjetaime Une photo publiée par Le Bonbon Nantes (@le_bonbon_nantes) le 4 Oct La Piste des Géants à Toulouse un projet semblable aux Machines de l'Île Autant vous dire que quand ma collègue toulousaine m'a annoncé cette nouvelle, avec articles à l'appui il existe bel et bien un projet de "déménagement" des machines entreposées dans l'atelier nantais vers un nouveau lieu Cela pourrait n'être qu'un atelier ouvert au public Une photo publiée par Le Bonbon Nantes (@le_bonbon_nantes) le 9 Juil Nous avons fouiné sur le site de la compagnie ne trouvant aucune allusion à ce grand projet urbain avec la ville de Toulouse nous avons demandé des explications à la compagnie La Machine en constatant notre réaction (un peu extrême on s'est dit qu'il était nécessaire d'écrire cet article vous êtes hyper attaché à l'éléphant aux Machines de l'Île mais surtout à toute cette singularité propre à Nantes cette folie ambiante et cette façon de voir la culture comme un attrait touristique riche et exceptionnel si Toulouse a la même chose que nous Home • Biography & Images • Gael Clichy Clichy was born in the city of Toulouse and began his football career playing for a host of amateur clubs in the Haute-Garonne departement such as JS Cugnaux he moved to the Provence-Alpes-Cote d’Azur region to play for professional club Cannes Clichy made his professional debut for the club in the 2002–03 season while the club was playing in the Championnat National he was convinced by manager and countryman Arsene Wenger to join Arsenal in England Clichy moved on in 2011 to more success with Manchester City adding two more Premier League titles (2011–12 and 2013–14) and two League Cups (2014 and 2016) He left England after 14 years for Turkish side ?stanbul Ba?ak?ehir in 2017 with whom he won the national league in 2020 Clichy served as a pundit on ITV’s coverage of Euro 2024 Angelos “Ange” Postecoglou – born 27 August 1965 – is a football manager and former player who is the head Danny Rohl – born 28 April 1989 – is a German football coach and former player Connie McLaughlin is a football presenter with the BBC and ITV She is ITV’s lead reporter with Scotland at the All Images and videos are the property of their respective owners.