With the launch of Pixel 9, Pixel introduced a new panorama mode
easy-to-use interface and delivers higher-quality panorama images — for both daylight and night time shots
we used this image to demonstrate its capabilities
Tristan Greszko took these photos with a Pixel 9 Pro; he’s a photographer on the Pixel development team who focuses on overseeing video and image quality
hiked to the very top of a summit in the Tetons with a friend to grab these photos
“It was more mountaineering than hiking,” he says
Tristan loves outdoor and panorama photography
and he was part of the team that worked on making it even better for Pixel
panorama mode worked via video — which is how most panorama modes work,” says Tristan
the camera is scanning the scene as you’re moving.” Tristan’s idea (at one time a “pipe dream” as he calls it) was to use Pixel’s HDR+ pipeline and its photo pipeline to create stitched photo panoramas that take better advantage of Pixel Camera’s capabilities
you get a lot less data than you do with photos,” Tristan explains
Pixel can stack all those photos and all their data together to come up with a really amazing image.” Here
Tristan gives a few tips on how to get the most out of Pixel’s upgraded panorama mode
"Rather than rotating your whole body when taking a panorama
just rotate the camera as much as you can while standing in place,” Tristan says
you’ll eliminate perspective shift — or those jagged edges you can get when each transition doesn’t quite line up — and create a smooth stitch
He also suggests trying to keep your movement as consistent and steady as possible by using Pixel’s level indicator
the higher quality your image will be,” Tristan says
you don’t need to think about things too much
Tristan says: Night Sight Panorama turns on automatically when it’s dark enough
His advice for great Night Sight pano shots
be as still as possible and then move to the next dot,” he says
you’ve probably tapped at the brightest spot on your display so that your camera focuses or balances the light of a scene
You don’t need to do this in panorama mode because Pixel software will take care of it for you
“There isn’t any tap to focus or tap to expose in panorama mode,” Tristan explains
“The camera is designed to balance the light and expose it correctly.” Plus
Tristan suggests trying different things with your pano shots
like using panorama mode’s full 360 capabilities to capture the entire scene around you or even shooting something vertically — he’s seen some shots where people bend over backwards to capture a vertical panorama
“It opens up a range of wild perspectives,” he says
“Panorama lends itself to experimentation really well.”
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Panorama Education has acquired Class Companion
an AI tool that seeks to provide feedback and tutoring to students
“Class Companion builds on our platform by giving educators powerful tools to personalize instruction
and engage students more deeply,” Panorama CEO and co-founder Aaron Feuer said in a statement
Class Companion’s product is designed to help teachers differentiate lessons for students
and offer recommendations based on students’ progress
The startup’s funding to date includes $4 million in a 2023 seed funding round led by Index Ventures
with participation from the OpenAI Startup Fund and angel investors including operator and advisor Gokul Rajaram
managing director of Otherwise Fund Terrence Rohan
founding research scientist at OpenAI and former senior director of AI at Tesla
Joining Panorama will give Class Companion additional reach
Class Companion CEO and co-founder Avery Pan said in a statement
adding that it will allow the companies to expand their “impact even further
enhancing the classroom experience with AI and enabling teachers to create better learning experiences for students.”
Panorama reports having 2,000 district customers across the U.S
an artificial intelligence-driven platform aimed at personalizing the college planning process for high school students
raised $2.8 million in a seed round led by Reach Capital
The startup said the funding will support its work establishing partnerships with higher education institutions globally
Kollegio’s platform is designed to act as a virtual college counselor
and serve districts and schools that lack a counselor or a sufficient number of counselors to serve its student population
and Tuesday Capital also participated in Kollegio’s funding round
The company is “tackling a major gap in the college admissions process,” James Kim
and a former Yale University admissions officer
The current admissions process “disproportionately favors those who can afford private counseling services,” Kim said
but Kollegio is “leveling the playing field.”
The company reports having 1 million students as users on the platform in 50 states and 190 countries
It says 66 percent are from households with less than $100,000 in annual income
The seed round “marks a significant moment for Kollegio as well as the future of college admissions,” Kollegio CEO and co-founder
said in a statement that because of the backing of investors like Reach and ECMC — the investment arm of student loan guaranty agency ECMC Group — and support from “forward thinking NGOs like JFF,” Kollegio is “confident that the market is ready for solutions like Kollegio to eliminate foundational barriers to college – no matter where students live
an augmented and virtual reality ed-tech company
makers of custom educational software and games
purchase a “lab” of 27 specialty laptops and cart
The product is designed to create immersive
often in STEM or career and technical education courses
The technology includes eye-tracking and hand-held styluses that aim to allow students to pick up
Acquiring Second Avenue Learning and integrating its interactive
standards-aligned learning modules into zSpace’s current offerings will allow zSpace to bolster its content and offer a larger set of tools to educators
The acquisition is a “transformative moment for zSpace and the future of education,” Paul Kellenberger
“By bringing Second Avenue Learning into the fold
we’re combining our immersive AR/VR platform with their exceptional ability to craft meaningful learning experiences.”
said in a statement that the deal is an “incredible opportunity to amplify our mission of blending technology with education to reimagine learning.”
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With Claude in Amazon Bedrock
School districts struggle to understand student needs holistically because critical data exists in numerous disconnected systems
"One of the biggest challenges for school districts is that their data is fragmented across different systems
and screening data all exist in separate places
making it nearly impossible to get a complete view of how students are performing," explains John Kennedy
formerly founder and CEO of Mesa (acquired by Panorama in 2023)
This fragmentation creates barriers to identifying struggling students and providing timely support
with Kennedy noting "About 20% of students nationwide are now chronically absent
making coordinated support even more crucial." With 14,400 districts operating independently
there's no centralized approach to addressing these widespread educational challenges
Panorama chose Claude for its performance quality and robust security capabilities essential for handling sensitive student information
"Claude outperformed alternatives in our internal evaluations while meeting our strict security requirements." The security dimension was critical because "Standard AI tools that improve by learning from user interactions simply cannot be used with sensitive student data due to privacy concerns."
Using Amazon Web Services (AWS) to implement Claude in Amazon Bedrock allowed Panorama to create an AI solution that maintains strict data privacy standards while working with specific student data context.
"Using Claude in Amazon Bedrock addresses data security concerns completely, ensuring we fulfill our obligation to protect sensitive student information while still delivering powerful AI capabilities," Kennedy emphasizes.
Claude powers multiple AI capabilities across Panorama's educational platform:
These capabilities address what Kennedy describes as a foundational need in education. Kennedy shares, "By creating a complete view of each student that integrates data from all district systems, we can provide powerful insights while maintaining full compliance with data privacy requirements through Claude's security protections."
Panorama envisions AI as a transformative force for building more responsive learning environments. Kennedy says, "We're creating implementation models based on real educational data that districts can share, establishing clear pathways for responsible AI adoption."
Panorama aims to "increase capacity in K-12 education when it's most needed—reducing teacher burnout while enabling personalized learning experiences" by developing education-specific AI implementations. This helps districts embrace AI's potential in ways that complement existing practices, positioning educators and students for success in an AI-influenced world.
Case Study
Panorama photography presents unique challenges
both in the field and during post-processing
PTGui has been a favorite powerhouse tool for photographers needing more control and better results than the basic stitching tools provide
this already excellent panorama stitching software gets a significant update
focusing on a streamlined DNG-based workflow
First things first: If you purchased a personal license on or after September 1st, 2022, you're already covered, as PTGui 13 is a free upgrade for you. Users with older licenses can purchase an upgrade at a reduced price
It's also a good time to consider the Pro version
as the feature gap between Standard and Pro continues to grow
The Pro license unlocks key functions like automatic optimum seam placement
but the only Pro-specific features discussed are automatic seam placement
One of the few advantages that panorama processing in Lightroom had was the DNG workflow
By keeping more of the raw file information
users had an easier time stitching first and then editing a completed panorama
compared to the general panorama workflow of making edits to individual images
PTGui supports a much more seamless DNG-based workflow
DNGs are designed to store raw image data captured by the camera sensor
With PTGui 13 supporting improved DNG handling and DNG export
stitch using PTGui’s host of advanced projection and alignment tools
then export a final DNG panorama that preserves as much of the raw data as possible
That final DNG panorama can then be easily edited in Photoshop or Lightroom
with virtually all the latitude of the original raw files
PTGui improved the white balance adjustment options
added support for chromatic aberration/purple fringing reduction
added support for reading embedded lens corrections from files like drone cameras or modern lenses
and continues to support the post-processing options added in PTGui 12
this means PTGui essentially supports a full raw editing workflow
It combines to make the slightly complicated panorama editing process easy to understand
By eliminating a lot of confusion around color spaces and file types
it should also yield higher-quality finished panoramas
PTGui mentions that the optimizer has been significantly improved
While I always found PTGui to work quickly and make great use of higher-end hardware (unlike some competitors)
PTGui says this should be most noticeable when optimizing large (100+ image) panoramas
Another area that has received optimizations is the seam-finding algorithm
The seams determine which portions of the finished image are made up of the various individual frames and are normally calculated at 1/8 resolution
you can squeeze out better results around moving objects or stitching errors by setting this to 1/4 or 1/2
the much faster algorithm makes these more powerful stitching settings cost far less time
If you’re shooting panoramas with lower image counts and have a reasonably fast computer
consider just defaulting to 1/4 to get even better results than from previous PTGui version defaults
This tool is designed to remove unwanted elements (like a tripod leg accidentally left in shot) or fill small gaps where source images might be missing coverage
The finished patch integrates with PTGui’s blending capabilities to create a seamless result
you can either patch directly by pasting in another portion of the image (Photoshop Patch-style) or export the patch portion of the image to another editor like Photoshop
then reimport that portion into PTGui to be blended back into the frame
While a potentially useful addition for some workflows
I found the interface a bit clunky compared to dedicated retouching tools
If your specific workflow benefits from fixing these issues before the final export
I suspect many users will stick to using the excellent Content-Aware Fill or near-magic Generative Fill tools in Photoshop on the final stitched panorama
If you’re planning on using the Patch Tool in your workflow
PTGui 13 reinforces why this software maintains its position as the gold standard for dedicated panorama stitching
While Adobe's built-in tools in Lightroom and Photoshop can handle simple panoramas
beginners will find PTGui more forgiving of shooting errors like slight tilting or imperfect nodal point alignment
Its wider range of projection options also gives far greater creative control over the final look compared to Adobe’s limited choices
Now with expanded support for single-shot 360 cameras
PTGui 13 is a good upgrade option for real estate photographers looking for a more advanced processing tool for 360 property photos
PTGui brings excellent support for generating HDRs
which can help address the dynamic range limitations of most 360 cameras
while the new batch processing options could streamline processing the dozens of 360 panos a typical property could yield
version 13 offers compelling reasons to upgrade
The streamlined DNG workflow is a genuine game-changer
simplifying the path to high-quality results with maximum editing flexibility
particularly for complex projects and when using higher-quality seam finding
in an era increasingly dominated by subscriptions
it's refreshing to see PTGui maintain its perpetual license model with a clear and fair upgrade path
If you're serious about panorama photography, PTGui 13 remains the top recommendation. It’s available for purchase now directly from the PTGui website. PTGui also offers a fully functional trial so you can try all the features for yourself.
DNG-friendly workflow makes PTGui integrate seamlessly into my preferred workflow
Already great processing speeds are now even better
Upgrade pricing feels fair for the longevity of the software and licensing model
Alex Coleman is a travel and landscape photographer. He teaches workshops in the American Southwest, with an emphasis on blending the artistic and technical sides of photography.
2025 1 p.m.“Chispa” and “Mall Town” both use the now mostly empty shopping mall as a backdrop — with very different goals.In this provided still from the film "Chispa," a spark of electricity flows through the main character's fingers
The film is part of the Portland Panorama film festival this month
features 120 films from both international creators and emerging Pacific Northwest filmmakers
said the goal of the festival is to fill the gap left by the end of the Portland International Film Festival during the pandemic
OPB “Weekend Edition” host Lillian Karabaic interviewed two filmmakers who have short films in the festival
The films are different — one is a fantasy thriller
one a documentary — but share one similarity: Portland’s Lloyd Center as a backdrop
The following transcript has been edited for clarity and length
00:00 / 09:04Lillian Karabaic: First, we’re talking to Karina Lomelin Ripper about her short film
steady shots watching a security guard and an electrician complete mundane work duties
But then the film rapidly changes after the electrician is hit by a jolt of electricity
It transforms into a dance video with a twist
Tell me a little bit about the inspiration for the film
In this provided still from film "Chispa," a shewolf haunts the Lloyd Center mall
Lomelin Ripper: I’m a Mexican-American director and working in the film industry
you don’t see a lot of female-presenting directors
and so the inspiration came from my experience with dealing with being a woman in the workplace
And I started to think about what other women experience in workplaces
and I’d been looking at the Lloyd Mall as a location to potentially film at
so I started thinking about who would work at the Lloyd Mall
and what the characters might be there that could have an interaction that could really kind of stem at the core of the themes of the film
which is a woman dealing with sexism in the workplace
I kind of felt like sexism was this background character in the film where it’s this specter that’s haunting every moment
As someone who spends a lot of time in the Lloyd Center
it felt almost strange to see the mall at the angles that you shot
It was kind of like seeing an old friend with a totally new haircut
Your cinematography really transforms it as a background
How did you think about the architecture and design of the Lloyd Center and how it contributed to the mood that you aim to convey
and I feel like I was really fortunate in that I got to work with cinematographer Sarah Whelden
and she’s just incredibly talented and brought this incredible eye to the space
She lived in Portland for a long time as well
so we were both just really familiar with the Lloyd Mall
There are all these really incredible architectural aspects to the mall that lend themselves to this
and I think experiencing short films at festivals
one thing is I feel like oftentimes the films take place in what filmmakers have access to
which is their apartment or house or a park
and I just was getting this feeling from the Lloyd Mall that they were really open to artists and they are really open to artists
Karabaic: As someone who used to work in the Lloyd Center and had to take trash out down those long hallways in the back that you shot in
“I’m so glad I didn’t see this film when I used to have to take the trash out in the dark because I would’ve just constantly been imagining a monster behind me.”
especially when you’re all alone and there’s the compactor is making noise
Ripper: I definitely had a buddy every time I was scouting those hallways for sure
Karabaic: Your film is part of the Portland Panorama Festival
Do you think that it fills a need in the Portland filmmaker community
I was so thrilled when I started hearing whispers of this festival coming and I was like
They’re doing the films at Cinema 21 and Hollywood Theater
both incredible exhibition spaces for filmmakers
I feel like that’s an aspect I run across with a lot of film festivals is
I spent all this effort and time on making sure my sound and picture is to a certain level
and it’s just incredible when you get to experience in a historic and just incredible theaters
this aspect of an international film festival here in Portland of really bringing in those filmmakers
but also just really showcasing all the incredible talent that’s based here in the Pacific Northwest
and I’m just so pumped and thrilled to be a part of the inaugural Portland Panorama
Karabaic: What message are you hoping audience to take away from your film
Not just being scared of the dark corridors in the Lloyd Center
but then it transforms and it kind of lends itself to these mythologies and themes of werewolves or the she wolf
and one of the things I discovered in my research was that the she wolf comes from this place of people or society being afraid of women transforming when take up space
It’s scary and intimidating and in some ways the women don’t need to change what they’re doing or how they’re doing it
It’s really the individual or the society that needs to transform
And that’s the ultimate message of my film is that society needs to wake up to women’s strength
director of “Chispa,” a short film that is part of the Portland Panorama film festival this month
Karabaic: Another film in Portland Panorama is a film about a different kind of transformation. Instead of electrician into she wolf, "Mall Town" documents the transformation of the Lloyd Center from mall to artistic community hub
director of “Mall Town.” What made you want to tell the story of the Lloyd Center’s evolution
It was during COVID and it was announced that Lloyd Center was going to close
and I was so blown away by the number of people who were near tears at the idea of the mall disappearing
That led me to go back and discover what made them all so special over the years
including looking back at the history of the mall
In this provided still from documentary "Mall Town," the Dairy Queen in the Lloyd Center mall food court is seen in archival footage
"Mall Town" is one of the 120 films at Portland Panorama film festival
you did extensive research on the Lloyd Center’s history for this film
Bernstein: Most people would be surprised to know that malls were not always where there were chain stores
Initially when they were created in the mid-20th century
the idea obviously was to focus on commerce
So there was original art commissioned for the Lloyd Center
There were celebrities and famed performers
Ella Fitzgerald performed at the Lloyd Center
Bobby Kennedy came and one of his last appearances before he was killed was a public appearance at Lloyd Center
So it’s quite amazing the history of that space and what it means to people in the community
Karabaic: Something that was interesting in your film is you really talked about how as these large anchor stores have left
artists and indie businesses are taking over the space
I think your film kind of explores the question: Can capitalism and community coexist
And I think that most of the creators who were there at the mall doing everything — there’s a magic show
But the point is it’s still going on and it’s still vibrant
I love that creative people and artists or seizing on this moment
but I appear briefly in “Mall Town” as an ice skater who skates in the Lloyd Center each week
How important do you think the Lloyd Center’s iconic ice rink is to its next act
and from what I have been told — not that I know all the secrets — but I have been told that whatever happens next
Will it be big enough for you to do all your fun tricks
I want people to know that Lloyd Center is still open
You may have imagined it or remembered it as
Tags: Culture, Portland, Film, Art, Creativity
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Walking the same halls: App State nursing graduate finds purpose where brother died
Going the distance: Graduate student breaks records for App State
College Gameday broadcaster Lee Corso set to retire, ends 38-year run
App at a Glance: Summer Edition May 10-August 10
Playlist of the week: Summer soundscapes throughout the High Country
Playlist of the Week: End of semester nostalgia
Students revive LGBTQ+ graduation
1 year with Norris: Chancellor reflects on leadership, shares goals for future
Meet Goldie: App State’s forgotten mascot
College Gameday broadcaster Lee Corso set to retire, ends 38-year run
App State baseball falls in lone game against Wake Forest
Seven students took to the stage to perform an array of speeches at Panorama Monday night
Topics ranged from the importance of LGBTQ+ artists to the history of the plant kudzu
The event was held at the Schaefer Center for the Performing Arts
Panorama has been hosted annually every spring semester since 2014
The event was hosted by the Department of Communication this year
The event provides a way for students to give TED Talk-style speeches on topics of their choosing
Whether students have a history in public speaking or not does not matter
The first speech of the night was “Rooted in Resilience,” written and performed by Anna Harrison
a junior anthropology and sustainable development double major
Her speech outlined how kudzu can act as a community builder within the South
Kudzu is native to Japan and China and was introduced to the United States in the 1870s to reduce soil erosion in areas that had been deforested
according to the Center for Invasive Species and Ecosystem Health
taking the title of “the vine that ate the south.” Harrison said during her talk that within 20 years of its introduction to the area
it was labeled as invasive and shunned by the South
“Communities are changing their perspective and really starting to work with kudzu,” Harrison said
“In Southeast Asia it’s not really an issue because people have a relationship with the plant.”
brought LGBTQ+ media to the stage in their speech “Your Favorite Artist’s Favorite Artist is Probably Queer
and That’s Important.” Their speech’s journey began with an important question: “Are the robots from Daft Punk queer?”
Short answer: yes, as well as many other musicians. From Elton John to the birth of house music, Magdanz said LGBTQ+ communities have always played a significant role in crafting U.S. culture and media. In March 2022, Florida passed the “Don’t Say Gay Bill,” prohibiting discussion of sexual orientation and LGBTQ+ history in the classroom
queerness is inevitable and you can never get rid of us,” Magdanz said
Freshman political science major Kinsleigh Lane found Magdanz’s speech particularly inspiring
“There’s so many things that are done by the queer community that nobody really notices,” Lane said
“There are so many people who are so anti-queer and don’t really see that what they are consuming is made by queer individuals.”
gave a speech entitled “Healthcare in Rural America,” a talk discussing the critical need for value-based healthcare systems in the U.S
Jackson has been working as a medical assistant at a value-based care system for several years
which they said makes them well-versed in the intricacies of the system
I came during the pandemic and I dropped out after my first semester,” Jackson said
and ever since I came back I felt very disconnected as a student because I work full time
I wanted to do Panorama because I didn’t want to graduate without putting my name on something related to App.”
senior Ryan Stukes gave a talk which included both speech and music entitled “Finding My Voice: A Journey Through Music and Self-Expression.”
Stukes is a Chancellor’s Scholar and an interdisciplinary studies major
she created her own major: Multicultural Marketing and Communications
Stukes said after her grandmother passed the first week of her freshman year
She has always been a musician and wanted to use this talent during her college career as a way for her to unabashedly explore her emotions
all of that emptiness I felt in my life had just run away,” Stukes said
Music improvisation became a guiding light through her struggles
she played her viola and performed from her heart
closing her eyes and crafting the melodies in real time
discussed the scary realities of our digital footprints in his speech “The Importance of Good Hygiene: Cyber Hygiene That Is.” His speech was interactive
encouraging audience members to take a look at the gaps in their education on cybersecurity
Freshman Sean Sica made connections between Jamaican athletes and U.S
scientific communities in his speech “What Jamaican Sprinters Teach Us About Shifting American STEM Culture.” Sica is a member of the honors college and a social studies education major
culture fails to promote scientifically-curious children
instead raising kids whose dream jobs include influencers and professional gamers
“Change the training plan and you can change the culture,” Sica said
Rose Benton is a senior who is a part of the accelerated masters program and is majoring in environmental politics and sustainable development
she brought her dual majors together in their speech “Environmental (In)Justice and Community Organizing: Building Resilience and Fostering Independence.” Taking a look at the effects of Hurricane Helene on Western North Carolina
Benton urged the audience to connect with their community like they did post Helene
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Panorama examines the journey of natural history specimens from field collection to museum display
Using archival footage and contemporary footage
Amie Siegel reveals how Western scientific expeditions extracted
Amie Siegel’s Panorama traces the complex processes of how cultural materials – once living – enter a museum collection and begin their afterlife as objects of display
The film brings to life a trove of dormant 16mm film reels the artist found in the Carnegie Museum of Natural History’s storage
Siegel re-edits these scenes of specimen collection across geographies and decades – scientists shooting birds
and felling mammals – as well as the creation of the museum’s dioramas to expose the extractive practices
and indigenous labor shaping these collections
The artist’s film reveals the transformation of once-living animals into museum specimens – skinned
Siegel’s present-day filming then turns the encased displays into cinematic windows
where the animals’ glass-eyed gazes convey layered histories
Siegel has made visible their journey to the museum by connecting their former lives as roving and flying creatures with their now emphatic
Whether suspended within a dramatic display or placed side by side in storage drawers
the specimens portrayed by Siegel now hold multivalent narratives of other places
and the cultural subjectivities of their collectors
By tracing this process in all its complexity
the artist offers a view of the museum as a place of overlapping temporalities and contexts where meaning and value shift and accrue
Amie Siegel traces the journey of 18th century British paintings to reveal lasting legacies of societal structures
Join a group of curious and connected film enthusiasts
new insights and inspiration accessible to everyone
A new BBC Panorama investigation that aired early this week revealed that baby food pouches from six major UK brands – including four leading manufacturers and two supermarkets – are failing to meet key nutritional needs for babies and toddlers and are often high in sugar
The investigation’s findings, which have also been shared on the BBC website
may leave parents and caregivers questioning the best approach to feeding young children
We spoke with Professor Emma Haycraft
an expert in psychology and public health whose research focuses on healthy development in children and adolescents
to get her response to the findings and advice on how families can ensure the nutritional needs of babies and toddlers are met
What are your thoughts on the investigation’s findings
“It’s easy to see how this has happened; brands often add fruits to their baby foods which make them more palatable (sweeter) to the babies or toddlers
but doing this adds natural fruit sugars which can soon add up
meaning babies and infants who are starting their journey onto solid foods can quickly end up consuming lots of sugar without parents even realising”
“Similarly other ‘recipes’ are adapted by these brands meaning that key nutrients are being cut down or out
“Commercial baby foods can be useful for feeding young children
but a downside is that the labels on the packets can mislead parents into thinking they are giving their child something they’re not.”
Do you think or government intervention is needed in the baby food industry
“While the recent Panorama investigation has shone a light on the issues with companies misleading families about the nutritional and health benefits of their products
this issue is not new so government guidelines may be required if companies continue to mislead parents with food products that are lacking in nutrients to ensure that children who consume these foods are being well nourished”
What key nutrients do babies and toddlers need
and are there any ingredients or foods that parents and guardians should avoid
“Babies and toddlers need a varied diet”
“The goal of initially introducing foods to babies (weaning) is about them exploring foods and learning how to eat and while they’re still consuming milk (breast or formula) they’re gaining essential nutrients from the milk.
it’s essential that they get all the nutrients they need from their foods
“Babies and toddlers should be offered vegetables
unflavoured yoghurts that don’t have added sugars)
“Parents should try to avoid offering babies and toddlers food with added salt or sugar. This includes foods with lots of natural sugars
“Offering whole foods – such as carrots – that are cooked and either puréed
or served as batons (if age-appropriate) is preferable to using processed versions
as it allows parents to know exactly what their child is eating.”
What advice would you give to parents looking to replace baby food pouches with home-cooked alternatives
“Offering a variety of foods is the way to go
and these can be foods that your family is eating but prepared so that your baby or toddler can consume them”
“This might mean cooking foods to soften them and then either mashing them with a fork or blitzing the food so that it’s a suitable texture or offering foods as finger-foods. It might also mean adding salt
or flavourings after taking out a portion for your child.
if you’re cooking potatoes for your family
or cut into sticks or wedges (if age appropriate) for young children
just ensure the potato skin is removed for very young children
“Or if you’re cooking Spaghetti Bolognese
This can be blended or cut into age-appropriate sizes and offered to your child.”
what advice would you give to parents looking to feed their young children nutritiously on a budget
“Commercial baby foods are very convenient
Offering children foods that the family is eating is a cost-effective way to introduce new foods to babies and toddlers”
“Batch cooking foods for babies and toddlers – and the family
around six months) are initially trying new tastes and flavours so don’t need much of each food as they’re also consuming breast/formula milk.
“Preparing and storing foods in ice cube trays can be handy as you can simply defrost a ‘cube’ of pureed or mashed food for your child to taste.”
To arrange an interview with Professor Emma Haycraft, email the Public Relations team or call 01509 222224
Loughborough is one of the country’s leading universities
with an international reputation for research that matters
and unrivalled achievement in sport and its underpinning academic disciplines
It has been awarded five stars in the independent QS Stars university rating scheme and named the best university in the world for sports-related subjects in the 2025 QS World University Rankings – the ninth year running
Loughborough is ranked 6th in The UK Complete University Guide 2025
10th in the Guardian University League Table 2025 and 10th in the Times and Sunday Times Good University Guide 2025.
Loughborough was also named University of the Year for Sport in the Times and Sunday Times Good University Guide 2025 - the fourth time it has been awarded the prestigious title.
Loughborough is consistently ranked in the top twenty of UK universities in the Times Higher Education’s ‘table of tables’
and in the Research Excellence Framework (REF) 2021 over 90% of its research was rated as ‘world-leading’ or ‘internationally-excellent’
In recognition of its contribution to the sector
Loughborough has been awarded seven Queen's Anniversary Prizes
The Loughborough University London campus is based on the Queen Elizabeth Olympic Park and offers postgraduate and executive-level education
as well as research and enterprise opportunities
pioneering researchers and creative innovators who provide students with the highest quality of teaching and the very latest in modern thinking
In Panorama City, construction is in the home stretch for a new affordable housing complex from Thomas Safran & Associates
Vista Terrace, located at 8130-8146 N. Van Nuys Boulevard
is a four-story building that is slated to feature 102 studio
and three-bedroom apartments above a 55-car garage when completed
Inclusive of supportive housing units, the apartments are to be restricted to renters earning between 30 and 70 percent of the area median income level
HED is designing the contemporary low-rise structure
which will feature amenities such as a courtyard
A social media post from general contractor Morley Builders indicates that work is now in progress for building interiors and landscaping ahead of a projected debut for the project in mid-2025
Vista Terrace, which is located near a future stop on Metro's East San Fernando Valley light rail line down Van Nuys Boulevard, is one of two large affordable housing developments in the near vicinity, following a 180-unit complex from Holos Communities which recently opened across Van Nuys Boulevard
Twitter / Facebook / LinkedIn / Threads / Instagram / Bluesky
Looking for affordable housing? Visit lahousing.lacity.org/aahr and housing.lacounty.gov
California's 2024 state income limits
Click here for additional affordable housing resources
GILFORD — Gunstock Mountain Resort’s Panorama chairlift will be operational again starting Saturday
according to a media release from the mountain on Tuesday afternoon
The lift has been down since Sunday due to a mechanical failure
“We are planning to have access to Gunstock’s summit
and glades return for skiers and riders starting Saturday
22,” Gunstock President and General Manager Robert Drake said
The issue with the lift is due to a failed gearbox
A gearbox transmits power to the drive in the lower terminal of the chairlift
A new gearbox was sent overnight via air freight to the resort
and mechanics are already working to replace the part
“With the expertise of Gunstock’s lift mechanics combined with an onsite consultation from the representative from the lift manufacturer
we were able to identify the cause of the problem and take immediate action,” Drake said
The release also stated passengers riding the lift at the time the issue was identified were safely removed
with the chairlift operating normally prior to its closure
Gunstock is committed to a lift infrastructure upgrade totaling more than $2 million over the next two years
Gunstock Area Commission Chair Doug Lambert provided context around the situation
“The entire East Coast ski industry has been having [lift] issues all season,” Lambert said
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Bacterial pneumonia is a significant public health burden
Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited
highlighting the need for a deeper understanding of the disease pathogenesis
we employed single-cell RNA sequencing of 444,146 bronchoalveolar lavage fluid cells (BALFs) from a large cohort of 74 individuals
including 58 patients with mild (n = 22) and severe (n = 36) diseases as well as 16 healthy donors
Enzyme‐linked immunosorbent and histological assays were applied for validation within this cohort
The heterogeneity of immune responses in bacterial pneumonia was observed
with distinct immune cell profiles related to disease severity
Severe bacterial pneumonia was marked by an inflammatory cytokine storm resulting from systemic upregulation of S100A8/A9 and CXCL8
primarily due to specific macrophage and neutrophil subsets
mild bacterial pneumonia exhibits an effective humoral immune response characterized by the expansion of T follicular helper and T helper 2 cells
facilitating B cell activation and antibody production
Although both disease groups display T cell exhaustion
mild cases maintained robust cytotoxic CD8+T cell function
potentially reflecting a compensatory mechanism
Dysregulated neutrophil and macrophage responses contributed significantly to the pathogenesis of severe disease
Immature neutrophils promote excessive inflammation and suppress T cell activation
while a specific macrophage subset (Macro_03_M1) displaying features akin to myeloid-derived suppressor cells (M-MDSCs) suppress T cells and promote inflammation
these findings highlight potential therapeutic targets for modulating immune responses and improving clinical outcomes in bacterial pneumonia
effective treatments beyond antibiotics and adjuvant therapy are lacking for bacterial pneumonia
a better understanding of the pathogenesis of bacterial pneumonia
is crucial for developing new therapeutic strategies
a systematic understanding of immune dysregulation during bacterial pneumonia remains elusive
Comprehensive and in-depth studies on the quantity
and characteristics of various immune cells
as well as the levels of pro- and anti-inflammatory factors at different stages of disease progression
The related disease protection or pathogenic mechanisms
especially those leading to severe disease
scRNA-seq analysis of BALFs can reveal the cellular composition
and dynamic immune responses in patients with bacterial pneumonia
shedding light on crucial inflammatory pathways and potential therapeutic targets
An overview of the study design and results for the BALF single-cell transcriptomic study
a Diagram outlining the overall study design
including 58 patients (22 patients with mild disease and 36 patients with severe disease) and 16 healthy donors
b The clustering result (Left row) of 65 cell subtypes (right row) from 74 samples
d Disease preference of major cell clusters as estimated using RO/E
e Representative images of hematoxylin and eosin staining of lung sections from patients with severe bacterial pneumonia (MSP01)
20 μm (main image; Left) and 20 μm (Magnified images
After adjusting for read depth and mitochondrial read counts
all high-quality cells were merged into an unbatched and comparable dataset for subsequent principal component analysis (See methods)
we clearly defined the cell subpopulation compositions in BALFs
providing an information-rich dataset for accurate annotation and comprehensive analysis of these cell types at different resolutions
suggesting their function in secreting antigen-specific antibodies
These findings indicate that effective B cell activation and antibody production may play an important role in bacterial pneumonia
the data revealed that each disease state in patients with bacterial pneumonia might exhibit a unique immunological fingerprint
Myeloid cells are the primary contributors to the production of pro-inflammatory cytokines in severe patients
Colored based on the eight major cell types (top left)
eight hyper-inflammatory cell subtypes (top right)
b Pie charts depicting the relative contribution of each inflammatory cell subtype to the cytokine and inflammatory scores in severe patients
c Heatmap depicting the expression of cytokines within each hyper-inflammatory cell subtype identified
d Lollipop chart depicting the relative contribution of the top ten cytokines in patients with severe disease
e Box plots of cytokine expression based on scRNA-seq and plasma profiling for healthy controls
Significance was evaluated using the Kruskal–Wallis test with Bonferroni correction significance was evaluated using the Kruskal–Wallis test with Bonferroni correction (*p < 0.05
f Heatmap plots of the sum of significant interaction among the eight hyper-inflammatory cell subtypes
g Dot plot of the interactions among inflammatory macrophages in severe patients
P values are indicated by the circle sizes
This underscores the significance of the hyper-inflammatory cell subsets and molecules (CXCL8 and S100A8/A9) as possible therapeutic targets for mitigating the immunopathogenesis seen in severely infected pneumonia patients
These findings provide molecular insights into the potential mechanisms underlying complex network of interactions between hyperinflammatory cell subsets in severe pneumonia
Immunological features of CD4+ T cell subsets
a The clustering result (Left row) of 15 CD4+ T cell types (right row) from 74 samples
colored according to the CD4+ T cell subtype
b Correlation between plasmablast with Tfh cells in mild patients
c Dot plots showing the expression of selected genes in Th2 cells across disease conditions
d UMAPs illustrating IFN-I response and unhelped signature scores for each CD4+ T cell
The red circle highlights the CD4T_14_Exhaustion cluster
which is characterized by high expression of interferon-I (IFN-I) response genes and an unhelped T cell signature
e Flow cytometry plots showing gating strategy and typical exhausted molecules in CD8+T cells from bacterial pneumonia (Top row: severe bacterial pneumonia; Bottom row: mild bacterial pneumonia)
f Dot plots showing the cell exhaustion-related markers in CD4_13_Pro and CD4T_14_Exhaustion across disease conditions
g Venn diagram illustrating the number of upregulated genes in CD4+ T cells
h Enriched GO biological process terms for upregulated genes in CD4+ T cells from mild (Left) and severe (Right) disease
i Dot plots showing CD4+ T cells related genes across disease conditions
these findings suggest a coordinated response between T cells and B cells in mild patients
leading to effective humoral immunity against bacteria
which appears to become uncoupled in severe patients
the regulatory function of Treg cells appears to be associated with the development of immune tolerance and the persistence of bacterial infections in severely affected patients
our findings suggest that the CD4+ T cell response in patients with mild symptoms primarily supports immune protection
it contributes to both inflammatory reactions and immunosuppression
Immunological features of CD8+ T cell subsets
a The clustering result (Left row) of seven CD8+ T cell types (right row) from 37 samples
b PAGA analysis of CD8+ T cell pseudo-time: the associated cell type and the corresponding status are listed
c Box plots showing the exhausted scores in CD8_04_Exhaustion and CD8_05_Pro subsets across disease conditions
Significance was evaluated using the Kruskal–Wallis test with Bonferroni correction (*p < 0.05
d Dot plots showing the cell exhaustion-related markers in CD8_04_Exhaustion and CD8_05_Pro subsets across disease conditions
e Flow cytometry plots showing gating strategy and typical exhausted molecules in CD8+ T cells from patients with severe (top row) and mild (below row) bacterial pneumonia
f UMAPs illustrating IFN-I response and unhelped signature scores for each CD8+ T cell
g Dot plots showing the cytotoxicity-related genes in CD8+ T cell subsets in patients with bacterial pneumonia
h Venn diagram illustrating the number of upregulated genes in CD8+ T cells
i Dot plots showing the activation-related genes in CD8+ T cell across disease conditions
these data suggest that the exhaustion observed in the CD8T_04_Exhaustion and CD8T_05_Pro subsets may be driven by ongoing type I IFN signaling coupled with a lack of adequate CD4+ T cell assistance
the enhanced expression of various cytolytic molecules in CD8+ T cells may be associated with immune protection in patients with mild conditions
These findings suggest that CD8 cells have undergone complete activation
particularly in individuals with mild symptoms
a The clustering result (Left row) of neutrophil subtypes (right row) from 74 samples
colored according to the neutrophil subtype
b UMAP plot of neutrophil clusters showing disease distribution
c PAGA analysis of neutrophil pseudo-time: the associated cell type and the corresponding status are listed
d Heatmap plots of selected genes in immature neutrophil subset across disease conditions
and S100A12 in immature neutrophil subset across disease conditions
f Heatmap plots of the sum of significant interaction between immature neutrophil clusters (Neu_01/02_Immature) and T cell subtypes in severe patients
g Venn diagram illustrating the number of upregulated genes in neutrophils
h Enriched GO biological process terms for upregulated genes in neutrophils from severe disease
i Box plots showing the functional scores in neutrophils across disease conditions
These findings indicate that immature neutrophils may contribute to the pathogenesis of severe bacterial infections in patients by promoting the formation of neutrophil extracellular traps (NETs)
these findings highlight potential targets for further investigation into the pathogenesis and therapeutic interventions for severe bacterial infections
these findings reveal that neutrophil heterogeneity and their gene expression profiles may play an important role in the immune response to bacterial infections
with heightened neutrophil activity potentially linked to disease severity and dysregulation of the immune system
a The clustering result (Left row) of macrophage subtypes (right row) from 74 samples
colored according to the macrophage subtype
b Pie charts depicting the relative percentage of macrophage subtype in mild (Left row) and severe (Right row) patients
c Box plots showing the expression scores of PD-L1 and IDO1 in macrophage subtypes
d Dot plots showing the inflammation-related genes in macrophage subtypes
e Venn diagram illustrating the number of upregulated genes in Macro_03_M1
f Enriched GO biological process terms for upregulated genes in Macro_03_M1 from severe disease
g Heatmap plots of the sum of significant interaction between Macro_03_M1 and T cell subsets
h A representative multicolor immunohistochemical (IHC) stained lung section from the SBP group is shown
and CD8+PD1+ T cells are indicated by green
Interactions between macrophages and CD8+ T cell subsets are highlighted with white dotted arrows
2000 μm (main image; Left) and 20 μm (Magnified images
implying that they are important drivers of the inflammatory response which may lead to increased tissue damage and disease severity
these findings highlight that M1- and M2-like macrophages may play pivotal roles in both immune suppression and inflammation
contributing to the difficulty in managing bacterial infections and leading to the worse prognosis observed in severely ill patients
the Macro_03_M1 cluster in severe patients is marked by a combination of immunosuppression
highlighting its multifaceted role in the pathology of severe infections
understanding these interactions between M-MDSCs (Macro_03_M1) and T cell subtypes provides insights into potential therapeutic strategies to enhance immune function in severe bacterial pneumonia
could inform the development of improved diagnostic and therapeutic strategies
a decrease in the proportion of most other major immune cell types was found in patients
particularly in those with severe bacterial pneumonia
implying a potential suppression of the adaptive immune response
and proliferating B cells were uniquely enriched in mild patients
suggesting a more robust adaptive immune response in these individuals
This is supported by plasma B cells showing greater expression of genes that encode the IgG constant regions
indicating their role in secreting antigen-specific antibodies
these results highlight the heterogeneity of immune responses in bacterial pneumonia
Eight hyperinflammatory cell subsets were identified in patient BALF
indicating targeted rather than global inflammatory dysregulation
including one macrophage subset (Macro_02_M1) and three neutrophil subsets (Neu_01_Immature
were identified as the primary contributors to the inflammatory cytokine storm
These subsets collectively accounted for over 80% of the inflammatory signature and exhibited a marked increase in abundance within the severe patient cohort
despite their shared role in driving the cytokine storm
these subtypes displayed distinct pro-inflammatory cytokine profiles
highlighting the diverse mechanisms contributing to disease severity
primarily produced by inflammatory neutrophil subtypes
were central mediators of the cytokine storm
a finding corroborated by both gene expression and plasma protein level validation
extensive chemokine-mediated crosstalk was observed between these hyperinflammatory subtypes
particularly involving inflammatory macrophages expressing a diverse repertoire of chemokine receptors
This complex interplay likely amplifies the inflammatory response
targeted therapeutic strategies aimed at these specific inflammatory subsets
potentially through modulation of S100A8/A9 and CXCL8
may offer more effective treatment strategies for mitigating the severe inflammatory pathology associated with bacterial pneumonia
Further studies are warranted to investigate these targeted therapies and elucidate the detailed mechanisms underlying this intricate inflammatory crosstalk
our results revealed a dichotomous role of their responses in bacterial pneumonia
with mild cases characterized by robust Tfh
and cytotoxic CD8+T cell responses that likely contribute to effective bacterial clearance
while severe cases exhibit features of immune dysregulation and impaired T cell function
in conjunction with increased plasmablasts and upregulation of genes related to B cell activation
suggests an effective humoral immune response in mild patients
which is crucial for producing high-affinity antibodies and establishing long-term immunity
potentially contributing to disease progression
While both mild and severe cases exhibited T cell exhaustion
characterized by upregulated inhibitory receptors (e.g.
and TIM-3) and exhaustion-associated transcription factors (PTPN6/11
exhausted CD8+ T cells retained robust cytotoxic function
evidenced by high expression of cytotoxic molecules (e.g.
potentially reflecting a compensatory mechanism to maintain control over bacterial replication
severe cases showed diminished CD8+ T cell responses
with fewer proliferating and effector CD8 + T cells
coupled with the expansion of a specific Treg subset (CD4T_04_Treg) expressing high levels of immunosuppressive TGF-β
further points towards an immunosuppressive milieu in severe cases that likely hinders bacterial clearance
our results highlight the importance of dissecting disease heterogeneity of T cells in bacterial pneumonia
as targeting specific T cell subsets or modulating the T cell response may offer tailored therapeutic strategies for different disease severities
play a role in exacerbating an overly inflammatory condition in severe cases
These immature neutrophils exhibit heightened levels of typical pro-inflammatory substances like S100A8/9/12 and CXCL8
along with markers of NETosis such as PADI4
which likely fuel the cytokine storm seen in severe infections
the increased expression of ARG1 in immature neutrophils and their interaction with effector T cells via HLA-E-KLRC/D/K1 and ICAM1/ITGAL axes suggest a potential involvement in suppressing T cell responses
further compromising adaptive immunity in severe patients
marked by excessive inflammation and compromised T cell activity
highlights a potential mechanism driving disease severity in bacterial pneumonia
these data emphasize the importance of targeting specific neutrophil subtypes and inflammatory pathways as a potential therapeutic strategy for severe cases of bacterial pneumonia
Our analysis underscores the dual role of macrophages in bacterial pneumonia
contributing to both immune dysregulation and inflammation
particularly in those with severe manifestations
alveolar macrophages were found to be depleted while M1- and M2-like macrophages increased
These cells displayed elevated expression of immunosuppressive molecules (PD-L1 and IDO1)
suggesting their involvement in suppressing T cell responses
a characteristic feature of severe disease
This immunosuppressive function was further corroborated by their interaction with exhausted and effector T cells via the HLA-I-KIR axis
which is known to inhibit T cell activation and function
these M-MDSCs also had a pro-inflammatory profile
with elevated pro-inflammatory molecules (including S100A12
and CXCL8) that likely contributed to the exacerbation of lung inflammation and tissue damage
simultaneously suppressing T cells and promoting inflammation
represents a critical mechanism underlying the severity of bacterial pneumonia
either by inhibiting their immunosuppressive function or mitigating their inflammatory capacity
may offer a promising therapeutic avenue for severe cases of bacterial pneumonia
There are important limitations to the interpretation of our study
this study used BALF samples taken from only one timepoint throughout the patients’ illness
thereby offering a limited perspective on its dynamic progression
further investigations incorporating longitudinal sampling are recommended to capture the temporal variations in immune cell populations and gene expression profiles throughout the infection and recovery phases
which primarily reflects the immune environment of the alveolar region
bacterial pneumonia may also affect other lung compartments (e.g.
incorporating analysis of additional lung regions may provide a more comprehensive insight into the immune response landscape in bacterial pneumonia
our study comprehensively maps the immune landscape of the lung microenvironment in bacterial pneumonia
revealing distinct immune profiles correlated with disease severity
Severe bacterial pneumonia was characterized by a heightened inflammatory response primarily driven by specific macrophage and neutrophil subsets
mild bacterial pneumonia exhibited a robust Tfh and Th2 cell response that promotes effective humoral immunity
Dysregulated neutrophil and macrophage responses contribute significantly to the pathogenesis of severe disease
These findings highlight potential therapeutic targets for modulating immune responses and improving clinical outcomes in bacterial pneumonia
This study was conducted in accordance with the Declaration of Helsinki and received ethical approval from the Ethics Committee of the General Hospital of the People’s Liberation Army of China (Ethics No
All patients or their legal representatives provided written informed consent prior to participation
Patients were excluded if they met any of the following criteria: (1) Age <18 years; (2) Viral pneumonia; (3) Autoimmune diseases; (4) Immunosuppression (e.g.
HIV infection with CD4+ T count <200 cells/mL); (5) Comorbidities (e.g.
Bronchoalveolar lavage fluid (BALF) samples were collected immediately after patients were diagnosed with mild or severe bacterial pneumonia
To minimize the impact of regional heterogeneity
BALF was performed on the lung segment exhibiting the most severe or recent radiographic evidence of infection
This targeted sampling strategy aimed to ensure that the collected BALF reflected the most clinically relevant aspects of the patient’s pulmonary infection
BALF samples from patients diagnosed with bacterial pneumonia underwent immediate processing (within 2 h)
BALF was filtered using a 100-μm nylon cell strainer and subsequently suspended in a chilled
These freshly isolated cells then underwent 10x Genomics single-cell RNA sequencing
To mitigate the risk of blood cell contamination
red blood cells were lysed using a dedicated lysis buffer during the BALF processing procedure
was rigorously assessed during the data quality control stage to ensure the absence of contamination within the final BALF dataset
Single-cell RNA sequencing libraries were prepared using the Chromium Single Cell 5’ Kit v2 (10x Genomics; PN-1000263) following the manufacturer’s protocol
Sequencing was performed on an Illumina NovaSeq 6000 sequencer with 2x150bp paired-end reads
Unsupervised cell clustering was performed in two consecutive rounds with the function: sc.tl.louvain
The first round (Louvain resolution 2.0) successfully delineated eight major cell types: plasmablasts
Canonical marker genes were then used to manually annotate subclusters within these major cell types
These subclusters are representative of distinct immune cell lineages
the sc.tl.rank_genes_groups function was used to identify cluster-specific signature genes
which were then cross-referenced to established gene markers to confirm correct annotations
Differentially expressed genes (DEGs) were identified using the sc.tl.rank_genes_groups function in Scanpy with the parameter use_raw=True
DEGs were determined based on cluster membership or disease condition using the Wilcoxon rank-sum test with an adjusted p value <0.01 and a fold-change threshold >1.5
CellPhoneDB analysis of ligand-receptor interactions was performed with parameters set to alpha = 0.01 and p value threshold = 0.01
which normalizes the expression of genes within predefined gene sets to reference genes
Statistical comparisons of cell state scores between disease phases were performed using the Kruskal–Wallis test with Bonferroni correction
Central and peripheral lung tissue sections from each lobe were fixed in 4% formaldehyde
and processed for histological examination
Sections (1 mm thick) were cut from FFPE blocks using a Tissue-Tek Prisma Plus automated staining system and Tissue-Tek Film (Sakura) following standard protocols
and stained with hematoxylin and eosin (H&E)
Freshly harvested tissues were fixed in 4% neutral buffered formalin and embedded in paraffin
Multiplex immunofluorescence staining was performed on 4-μm tissue sections using the PANO 7-plex IHC Kit (cat#0004100100
Panovue) according to the manufacturer’s protocol
and subjected to heat-mediated antigen retrieval in citrate acid buffer (pH 6.0) using microwave incubation
Following a 10-min incubation with a blocking buffer at room temperature
sections were incubated with primary antibodies against CD8 (CST70306
Sections were then incubated with a horseradish peroxidase-conjugated secondary antibody (anti-rabbit or anti-mouse) for 10 min at room temperature
Signal amplification was performed using tyramide signal amplification reagents (0004100100
Nuclei were counterstained with 4’,6-diamidino-2-phenylindole (DAPI)
and stained slides were scanned using the Mantra System (PerkinElmer)
R and Python were used for statistical analyses and visualization
the following symbols were used to represent p values: ns (p > 0.05)
Customized data analysis scripts utilized in this study are available upon reasonable request
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Single-cell landscape revealed immune characteristics associated with disease phases in brucellosis patients
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Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
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Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8+ T cells
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We gratefully acknowledge the participation of Beijing Digitf Biotechnology Co.
(Beijing) for the support of data analysis
(Qingdao) for the support of cloud computing platform
(Beijing) for construction of single-cell sequencing Library
Ranran Gao (Analytical BioSciences) and Xiaochen Pan (Yiyan) and Penglei Yang (Yiyan) for their contribution
Shanghai Jiao Tong University School of Medicine) for assistance with H&E and IHC data analysis and Servicebio Co.
(Wuhan) for their support with IHC experiments
This work was supported by grants from the National Science Foundation for Young Scientists of China (Grant No
the National Key Research and Development Program of China (Grant Nos
Laurence Don Wai Luu was supported by a UTS Chancellor’s Research Fellowship
These authors contributed equally: Kun Xiao
College of Pulmonary & Critical Care Medicine
The Eighth Medical Center of Chinese PLA General Hospital
School of Biotechnology and Biomolecular Sciences
Respiratory and Critical Care Medicine department
Department of Pulmonary and Critical Care Medicine
China Aerospace Science & Industry Corporation 731 hospital
The Sixth Medical Center of Chinese People’s Liberation Army General Hospital
Department of Respiratory and Critical Care Medicine
Anzhen hospital afflicted to Capital medical university
conceptualized the study and contributed materials and reagents
contributed to the analysis tools and performed the software; Y.Ca.
All authors have read and approved the article
The authors declare no competing interests
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DOI: https://doi.org/10.1038/s41392-024-02093-8
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The uMI Panorama GS PET/CT system is a new long-axial-field-of-view scanner featuring high sensitivity
The aim of this study is to assess the PET system on the basis of the National Electrical Manufacturers Association (NEMA) NU 2-2018 and European Association of Nuclear Medicine Research Limited (EARL) standards
and coregistration accuracy were evaluated following the NEMA NU 2-2018 standard
Additional experiments included energy resolution
a 175-cm-long scatter phantom for count rate and TOF resolution
as well as the compliance with the EARL guideline
an 18F-FDG PET patient study was reconstructed with various frame durations
Results: The PET system achieved sub–3-mm transaxial and axial spatial resolutions at a 1-cm radial offset
The sensitivities with the 70-cm-long and 200-cm-long line sources were observed to be 176.3 and 90.8 kcps/MBq
The noise-equivalent count rates (NECRs) of the 70-cm-long and 175-cm-long scatter phantoms were measured to be 3.35 Mcps at 57.57 kBq/mL and 2.24 Mcps at 33.27 kBq/mL
The TOF resolutions for both phantoms were approximately 189 ps at 5.3 kBq/mL and lower than 200 ps below the NECR peaks
The absolute count rate errors of all 34 acquisitions were less than 3% below the NECR peak for the 70-cm-long scatter phantom
With the standard NEMA image quality phantom experiment
the contrast recovery coefficient varied from 68.17% to 94.20% and the background variabilities were all below 2%
The maximum PET/CT coregistration error was 1.33 mm
the gaussian filter of 5-mm full width at half maximum could produce acceptable images
The patient data demonstrate visually satisfactory image quality with short frames (less than 1 min)
Conclusion: The uMI Panorama GS exhibits spatial resolution and TOF resolution similar to those of the uMI Panorama system (35-cm axial field of view)
and count rate performances are expected to yield superior image quality and offer new opportunities for various clinical applications
The integration of PET/CT systems, which was initially developed in the 1990s (1,2)
has rapidly supplanted nearly all stand-alone PET systems
it has emerged as a routinely used modality across various clinical applications
thereby manifesting widespread application in clinical scans
the advent of LAFOV scanners with improved TOF resolution emerges as a pivotal trend that is shaping the future landscape of PET imaging
In contrast, the recently established uMI Panorama platform (9) affords the flexibility to extend varying axial lengths
giving rise to the new LAFOV 148-cm-long scanner
denoted as the digital uMI Panorama GS PET/CT system
The 148-cm axial length of the PET scanner provides sufficient high sensitivity and adaptability for most clinical scans
The whole-body scan from head to thigh can position the brain within a considerably heightened sensitivity region
this scanner offers a head-to-knee scan option
and its axial length adequately accommodates nearly all pediatric imaging requirements
Total-body imaging is also feasible even for shorter subjects through knee bending
whereas taller patients exceeding 1.5 m benefit from the availability of 2-bed acquisitions
selected patient data were demonstrated to elucidate the clinical merits of this new LAFOV PET scanner
The uMI Panorama GS integrates a 160-slice CT scanner with a LAFOV PET system. The CT adheres to the identical configuration as the uMI Panorama (9). The specifications of PET system are given in Table 1
Benefiting from the extendable design of the uMI Panorama platform
each equipped with 7 detector cells arranged along the axial direction (LYSO crystal array with full coverage of silicon photomultipliers)
List-mode data are stored for clinical data acquisitions
with coincidences of all rings recorded (maximum acceptance angle of 62°)
The time coincidence window is configured independently for different unit pairs to optimize coincidence retention within the field of view (FOV)
The minimal discretized bin for TOF measurement is 6.1 ps
Performance measurements in this paper were basically following the NEMA NU 2-2018 (32) and EARL standards (33)
The acquired data for all experiments involved in this study were processed with the software tool kits provided by the manufacturer on the clinical system
including the nonstandard NEMA tests and the EARL study
The applied tool kits have undergone rigorous testing and validation by the manufacturer
Filtered backprojection reconstructions were performed without attenuation
and the image voxel size was set to 0.6 × 0.6 × 0.8 mm3
and tangential directions were calculated as instructed by the NEMA NU 2-2018 standard
Standard NEMA sensitivity measurements were performed using a 70-cm-long polyethylene tube filled with an initial activity of 8.9 MBq of 18F-FDG solution
The tube was added consecutively with 5 concentric aluminum sleeves of identical length and thickness (1.25 mm)
Extrapolations of the 5 measured values were executed to obtain the final sensitivity
The procedure was repeated with the tube positioned at a 10-cm radial offset
Random subtractions were conducted using the coincidences within the delayed time window
additional experiments were conducted by applying a 2-m line source (10.5 MBq) along with a set of 2-m concentric aluminum sleeves following the same procedure as the aforementioned 70-cm-long sensitivity measurement
used for these measures is a 20-cm-diameter
70-cm-long polyethylene cylinder positioned at the FOV center along the axial direction
A 70-cm-long tube was axially inserted into the cylinder phantom at a radial offset of 4.5 cm
which was injected with 1.7 GBq of 18F-FDG at the beginning of the acquisition
34 independent raw data acquisitions were performed
and the activity at the beginning of last acquisition was 26.0 MBq
Random estimation was extracted from the coincidences estimated within the delayed time window
as well as scatter fraction and NECR count rates
were subsequently determined in accordance with the NEMA NU 2-2018 standard
Additionally, the same experiment was repeated using a 175-cm-long phantom (21)
formed by concatenating 2.5 70-cm scatter phantoms
The tube was injected with 2.6 GBq of 18F-FDG at the beginning of the acquisition
and the activity at the beginning of the last acquisition was 40.1 MBq
and NECR count rates were analyzed following the NEMA NU 2-2018 standard across 34 acquisitions
The accuracy analysis was performed using data obtained from the 70-cm-long NEMA scatter phantom assessing the count rate performances. The 34 acquisitions were reconstructed independently with all necessary corrections except for the decay correction. Dead time correction was applied using the adaptive nonparalyzable model (35)
The reconstructions followed the current clinical protocol for GS at Peking Union Medical College Hospital (PUMCH) as listed here: ordered-subset expectation maximization/TOF/point-spread function
The accuracy analysis focused solely on the 65-cm center region along the axial direction
Data measured with 70-cm-long and 175-cm-long NEMA scatter phantoms were also evaluated for the TOF resolution (21)
The line-source position within the scatter phantom was determined by reconstructing the image with non-TOF point-spread function reconstructions
All 34 acquisitions were parsed and analyzed in accordance with the NEMA NU 2-2018 standard by correcting for scatter
The TOF resolution at 5.3 kBq/mL was interpolated from the TOF–activity curves
The NEMA NU 2 IQ phantom was applied for this evaluation
The background activity was 5.0 kBq/mL at the beginning of the acquisition
also applied for the count rate measurement
The line source inside the scatter phantom was filled with 105 MBq of 18F-FDG
Six spheres inside the phantom (with inner diameters of 10
and 37 mm) were filled with an activity ratio of 4.0:1 with respect to the background
The phantom was initially measured for 30 min
The data were reconstructed using the current clinical protocol for GS at PUMCH
The contrast recovery coefficient (CRC) of all 6 spheres
as well as the lung residual were calculated as described in the NEMA NU 2-2018 standard
To characterize the performance of the system with varying scan durations and delayed times (21)
4 additional acquisitions were conducted after 3
and 30 min for each data were independently reconstructed
and lung residual were calculated for each reconstructed image
the CRC and BV were averaged over the results of 5 independent time frames
Three spheres with an inner diameter of 13 mm
each filled with 2 MBq of 18F-FDG activity and CT contrast (Ultravist 370; Bayer Vital) mixture
were used to measure the coregistration accuracy of the PET and CT images according to the NEMA NU 2-2018 standard
0) cm were fixed by the support pad (made of ethylene vinyl acetate foam
∼900 Hounsfield units in CT images) at locations of 5 and 100 cm from the tip of the patient table
lead blocks weighing 115 kg were placed on the patient table according to standard requirements
Both CT and PET images are reconstructed using the 1024 × 1024 matrix with a 600-mm FOV and a 0.5-mm slice thickness
Note that the PET images were reconstructed with an ordered-subset expectation maximization/TOF/point-spread function
without scatter and attenuation corrections
The maximum coregistration error and the maximum ratios of PET and CT were calculated following the NEMA NU 2–2018 standard
the quantitative recovery of the uMI Panaroma GS system was also assessed using an independent NEMA/International Electrochemical Commission NU2 IQ phantom following the EARL guideline
The phantom was filled with 18F-FDG at a concentration of 2.80 kBq/mL for the background at the beginning of the acquisition
All 6 spheres were filled with activity at a sphere-to-background ratio of 10
The phantom was positioned identically to the NEMA NU 2-2018 standard IQ experiment
A single-bed PET scan was acquired for 5 min
The data were reconstructed using the clinical protocol at PUMCH
volumes of interest were extracted for each sphere to calculate the recovery coefficient of maximum
and peak values in the reconstructed image
Postgaussian kernels with various full widths at half maximum were applied to smooth the reconstructed image
ensuring compliance with the EARL protocol for this system
diagnosed with metastatic renal cell carcinoma
underwent a scan of 85 min after administration of 168 MBq (4.5 mCi) of 18F-FDG
A single-bed position from vertex to knee was acquired for 5 min
and 15 s were reconstructed from the list-mode data using the current clinical protocol for GS at PUMCH
The human study had been approved by the Institutional Review Board of PUMCH
and the patient had signed an informed consent form
Brain images were reconstructed from the same dataset with a voxel size of 0.6 × 0.6 × 0.6 mm3 and a gaussian filter of 0.5-mm full width at half maximum
Two additional patients were also reconstructed and shown in the supplemental material (supplemental materials are available at http://jnm.snmjournals.org)
74 kg) was injected with only 29 MBq (0.79 mCi) of 18F-FDG and scanned for 20 min
160 kg) had a larger body mass index and underwent a scan of 110 min after administration of 444 MBq (12.0 mCi) of 18F-FDG
The spatial resolution results at 6 different positions are shown in Table 2
A sub–3-mm resolution is achieved at the center of the transaxial FOV
The sensitivity profiles of 70-cm-long and 200-cm-long line sources at the transaxial center and the off-center position (10 cm) are shown in Figure 1. The detailed system sensitivities are summarized in Table 3
(A) Axial sensitivity profile of NEMA standard 70-cm-long line source positioned at transaxial center and 10 cm off-center
(B) Axial sensitivity profile of 200-cm-long line source positioned at transaxial center and 10 cm off-center
Sensitivity Measured with 2 Line-Source Configurations
The profiles of the count rate performances for the 70-cm-long and 175-cm-long scatter phantoms are shown in Figure 2. Numeric results are summarized in Table 4
The peak NECRs of 70-cm-long and 175-cm-long scatter phantoms were measured to be 3.35 Mcps at 57.57 kBq/mL (total dose
34 mCi) and 2.24 Mcps at 33.27 kBq/mL (total dose
The 2 scatter phantoms demonstrate a similar scatter fraction (∼30%) at peak NECRs
The decrease of true activity after reaching the true peak is due to the system bandwidth limit
when the random count rate increases dramatically faster compared with that of true events
and NECR as functions of activity concentration for NEMA standard 70-cm scatter phantom
and NECR as function of activity concentration for 175-cm scatter phantom
(C) NECR as function of activity concentration for both 70-cm-long and 175-cm-long scatter phantoms
Dashed lines correspond to NECR peaks for both phantoms
(D) Scatter fraction as function of activity concentration for both 70-cm-long and 175-cm-long scatter phantoms
Scatter fractions at 5.3 kBq/mL for 70-cm-long and 175-cm-long phantoms are 34.13% and 35.09%
and scatter fractions at peak NECR are 29.94% and 30.85%
(E) TOF resolution as functions of activity concentration for both 70-cm-long and 175-cm-long scatter phantoms
TOF at 5.3 kBq/mL is 188.8 and 189.7 ps for 70-cm-long and 175-cm-long phantoms
and TOF at peak NECR is 196.8 and 195.2 ps
The accuracy of the standard 70-cm-long NEMA scatter phantom was calculated for the 34 acquisitions. The maximum and minimum errors of each slice among all the reconstructed images are visualized with respect to the activity in Figure 3
The absolute maximum and minimum count rate errors below the peak NECRs were observed to be 1.29% and 2.02%
Accuracy of NEMA standard 70-cm-long scatter phantom
Turning points at high activity correspond to scenarios when measurement reached system bandwidth limit
The profile of TOF resolution is illustrated in Figure 2D, and the numeric results are presented in Table 4
the observed TOF resolution ranged from 188 to 197 ps across different activities below the NECR peaks
the measured energy resolution at 5.3 kBq/mL for the 70-cm-long NECR phantom was 9.7%
The results for time frames of 30, 5, and 2 min are presented in Table 5
With the standard NEMA acquisition time (30 min)
the CRC ranged from 68.17% to 94.20% and BV varied from 0.91% to 1.70% for the 6 hot spheres
Reconstructions of reduced time frames yielded higher BV for all spheres
the CRC of large spheres fluctuated around the mean value with reduced time frames
whereas that of the 10-mm sphere decreased from 68.17% to 65.60%
The reconstructed images of different delay times and different time frames are demonstrated in Figure 4. The CRC and BV of the 37-mm sphere, the BV of the 10-mm sphere, as well as the lung residual error for all reconstructed images are demonstrated in Figure 5
Reconstructed images at different delay times with various time frames
The PET/CT coregistration accuracy results are shown in Table 6
The recovery coefficients before and after smoothing are shown in Figure 6
Compared with the EARL version 2.0 standard region
most spheres exhibit relatively higher recovery coefficients
especially for the 10-mm and 13-mm spheres
With the gaussian filter of 5-mm full width at half maximum applied
nearly all spheres could fall into the EARL version 2.0 standard regions and satisfy this criterion
Recovery coefficients based on EARL guideline
Left to right: maximum recovery coefficient (RCmax) of all 6 spheres
mean recovery coefficient (RCmean) of all 6 spheres
and peak recovery coefficient (RCpeak) of all 6 spheres
The patient reconstructed images from various time frames are presented in Figure 7
revealing 3 representative lesions with subcentimeter diameters of 3.9
The reconstruction of the 15-s frame demonstrated satisfactory lesion detectability
Noise contamination was evident at shorter time frames
whereas the 30-s frames maintained acceptable noise levels in the clinical images
Supplemental Figure 1 presents images of the brain with the same patient data
The low-dose and high–body mass index cases are shown in Supplemental Figures 2 and 3
Clear demarcations of reported lesions (indicated by arrows)
The PET system has been assessed according to the NEMA NU 2-2018 standard (32) and the EARL guideline (33) along with some dedicated experiments to characterize LAFOV scanners
the measured results for the GS system are comparable to the reported results of uMI Panorama with a 35-cm AFOV
both systems are announced to be developed based on the same platform with identical transaxial geometry
The sensitivity at the center position of the 70-cm-long line source achieved equivalent sensitivity (∼176 kcps/MBq) as the uEXPLORER (21) and Biograph Vision Quadra (24)
Both the GS and uEXPLORER systems use identical crystal sizes and exhibit similar transaxial geometry
Despite the shorter AFOV compared with the uEXPLORER (acceptance angle of 57°)
the results of GS are practically compensated by a larger acceptance angle (62°)
GS yields a scaled sensitivity of 106.8 kcps/MBq at the central transaxial FOV
The NECR of the 70-cm-long phantom shows a lower peak activity at 57.57 kBq/mL compared with that of the Panorama 35 (9). Nevertheless, the current NECR and accuracy performances still cover a wide dynamic range for nearly all contemporary clinical applications (37)
The expanded time window is expected to capture more coincidences at the peripheral transaxial FOV
the increase in random events also occurs linearly with the extended time window
theoretically deteriorating the final numeric performance of NECR
The TOF resolution observed for the 70-cm-long scatter phantom data was less than 200 ps over the entire count rate range in the experiment, resembling the results of Panorama 35 (9)
Similar TOF performances of these 2 systems demonstrate consistent detector designs of the Panorama platform
In terms of the 175-cm-long scatter phantom
the TOF resolution at 5.3 kBq/mL and peak NECRs are similar to those of the 70-cm-long scatter phantoms
These observations demonstrate stable TOF performances for different phantoms at various activity levels
This trend does not apply to larger spheres
For the image without postsmoothing, the biggest maximum recovery coefficient was observed for the 2 smallest spheres (diameters of 10 and 13 mm), which may be attributed to the small size of the volumes of interest and the resolution modeling. Similar results were reported for the Biograph Vision (36)
resulting in an acceptance angle of approximately 41° and therefore yielding a sensitivity gain of ∼1.6 compared with that of the uMI Panorama 35 (acceptance angle of ∼25°)
which can be visually supported by brain images shown in Supplemental Figure 1
The uMI Panorama GS demonstrates commensurate spatial resolution
and energy resolution with the uMI Panorama system (35-cm AFOV)
its notably enhanced sensitivity yields improved IQ for the IQ phantom and patient
Achieving a peak NECR rate of 3.35 Mcps at 57.57 kBq/mL
renders the system adaptable for a wide range of clinical and research applications
The combination of the above features positions the uMI Panorama GS as the new benchmark in the class of LAFOV scanners
This study was sponsored in part by National High Level Hospital Clinical Research Funding (2022-PUMCH-B-071)
CAMS innovation fund for medical science (Nos
and National Key Research and Development Program of China (No
No other potential conflict of interest relevant to this article was reported
QUESTION: What are the performance characteristics of the uMI Panorama GS PET/CT system
according to the NEMA NU 2-2018 and EARL standards
PERTINENT FINDINGS: The uMI Panorama GS with a 148-cm AFOV demonstrated high sensitivity
and spatial resolution (<3 mm at center)
accompanied by a remarkable count rate performance and quantitative accuracy
Using appropriate filtering (5-mm gaussian)
the system demonstrates capability to attain EARL compliance
thus revealing its harmonization capabilities with other scanners
IMPLICATIONS FOR PATIENT CARE: The uMI Panorama GS offers highly effective diagnostic capability on lesion detectability with reduced dose or acquisition time
the system exhibits versatility in accommodating applications using various tracers
We acknowledge helpful discussions with Dr
Hancong Xu from United Imaging Healthcare about performance experiments and data analysis
Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions
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Mendez opened the scoring on a three-yard run in the first quarter and added a 20-yard touchdown run along with the two-point run to make it 14-0 before halftime. His third touchdown came on a 37-yard run that gave the ninth-seeded Pythons (8-6) a commanding 30-7 lead early in the fourth quarter. He also recovered an onside kick with eight seconds left to ice the win.
“I kind of wanted the ball and every time I got it I tried to put it in,” said Mendez, a senior running back and linebacker. “I worked too hard not to give it everything I had. I appreciate my coach relying on me so much.”
Coach Adrian Beltran raised the trophy proudly before handing it over to his players to celebrate the historic accomplishment — the Pythons’ lone gridiron crown since the school opened in 2006.
Giovanni Zermeno scored on runs of two and 15 yards and also scored on a two-point conversion for Panorama, which was playing in its third final in four years, having previously lost in the finals to Taft 21-20 and the Kennedy 22-21.
Carlos Herrera threw a 41-yard touchdown pass to brother Edwin to get Van Nuys on the scoreboard with three minutes left in the third quarter, then ran for a seven-yard touchdown with 7:44 left in the game.
Abraham Ceja blocked a punt, scooped up the bouncing ball and ran 39 yards to the end zone to pull the seventh-seeded Wolves (8-6) to within 30-21 at the 5:19 mark.
Jeremy Rivas scored on a four-yard reverse and Hector Gonzalez caught the two-point toss from Carlos Herrera for the game’s last points with 12 seconds left.
Van Nuys was seeking its first City crown since claiming back-to-back 3A titles under two different coaches in 1980 and 1981.
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we deeply value the voices and perspectives of our global community
After receiving feedback from artists and community members
we’ve taken time to reflect on how this initiative can be more inclusive
we have broadened the scope of the open call to include all regions that make up East and Southeast Asia
welcoming submissions from everyone who identifies with this heritage
We are grateful for your engagement and remain committed to fostering a platform that celebrates diverse stories and identities
Note: the article on Picter will be updated accordingly)
In celebration of the vibrant cultures and rich visual storytelling traditions of East and Southeast Asia
PhotoVogue is launching a Regional Open Call for photographers and videomakers from these regions
This initiative aims to discover and promote the most talented visual artists from East and Southeast Asia, providing them with opportunities to emerge and collaborate within the Condé Nast global network.
The call welcomes all genres—from fashion to documentary, fine art to reportage—and invites submissions from those working in photography and/or video. It is open to anyone who identifies with the heritage of East and Southeast Asia, whether based in the region or elsewhere in the world. Applicants must be at least 18 years old.
Chiron DuongWe are seeking diverse voices that reflect the region’s multicultural essence, capturing both its rapidly evolving urban landscapes and deeply rooted cultural heritage.
Submissions will be evaluated by a jury composed of Condé Nast editors from across the globe.
A curated selection of the best submissions will be featured across Vogue’s global network, with selected artists potentially collaborating on editorial projects. The most outstanding works will also be showcased at the next edition of the PhotoVogue Festival. In addition, three artists will receive a total of $8,000 in grants—details below.
Keep an eye out! Throughout the duration of the open call, we’ll be rolling out exciting opportunities in collaboration with various Vogue editions across the region—offering even more ways to showcase and support emerging talent.
PhotoVogue is a global Condé Nast initiative offering artists the opportunity to be published and commissioned across its 32 markets and commercial partners. Its global reach extends to events, exhibitions, portfolio reviews, and talks—fostering creativity and diversity in image-making.
PhotoVogue’s mission is to champion talent, engage underrepresented communities, and enhance visual literacy—shaping a more just, ethical, and inclusive visual world. To scout for talent worldwide, PhotoVogue promotes both Global and Regional Open Calls focused on specific regions and communities.
Photographers and videomakers from East and Southeast Asia, including members of the diaspora, working across all visual genres.
This Open Call welcomes photography, video, and multimedia projects across all artistic genres.
The jury will consist of Vogue editors from around the world, ensuring a broad and inclusive perspective.
PhotoVogue reserves the right to include or disqualify participants based on adherence to our Code of Conduct, ensuring our platform remains a safe, inclusive, and respectful space for all members of our community.
A total of $8,000 in grants will be awarded to three outstanding artists:
$4,500 – Outstanding Vision GrantFor an artist whose work redefines creative boundaries and sets new artistic standards.
$2,000 – Vision GrantFor an artist with a unique perspective and a strong artistic voice.
$1,500 – Rising Voice GrantFor a promising artist whose work shows originality and strong potential.
Be showcased at the next edition of the PhotoVogue Festival
Have the opportunity to be published in Vogue editions worldwide
Be selected to participate in the next PhotoVogue Virtual Portfolio Reviews
Stay tuned for more exciting announcements and opportunities related to this Open Call—we’ll be sharing updates throughout the duration of the call.
Algiers, February 19, 2025 – FIAT El Djazair announces the launch of the new Fiat Doblò Panorama, a versatile leisure activity vehicle designed to meet all the mobility needs of Algerian families.
With this third model produced at the Tafraoui plant, the FIAT brand takes a new step in Algeria by offering a vehicle that combines the comfort of a sedan with the modularity of a utility vehicle.
Inside, it incorporates a new steering wheel displaying the FIAT logo, as well as a new dashboard and new fabrics for the seats.
It offers a boot capacity of 775 liters, which can be expanded to 3000 liters by folding the rear seats and the front passenger seat, making it a true utility vehicle when needed.
Starting from February 19, 2025, interested customers can register at any FIAT El Djazair dealership to order their Doblò Panorama.
the first conscious fashion photography festival that focuses on the common ground between ethics and aesthetics
BASE Milano will host a series of exhibitions and talks analysing the interrelation between humans and Nature
and the relations of kinship we can create with animals
complemented by satellite events at the city's finest galleries
The exhibitions at the PhotoVogue Festival include: “The Tree of Life: A Love Letter to Nature”
Check 2025 and past exhibitions here
The “Latin American Panorama” exhibition celebrates the creativity from Latin America and its diaspora
Created in occasion of Vogue Mexico & Latin America’s 25th anniversary
the Local open call has gathered talented artists whose works depict the multilayered essence of the region
From environmental and documentary to fashion photography
through their work the artists will deal with urgent matters and analyse the multiculturalism of the region
The exhibition on display at BASE features work by 42 photographers and video makers selected by a jury comprising Condé Nast staff from across the globe and experts from the international visual community.
Alessandro Bo
Allan Salas
Ana Margarita Flores
based in United Kingdom of Great Britain and Northern Ireland
Angela Ponce
Christopher Pérez
Diego Bendezu
Diego Moreno
Diego Vourakis
Dolores Medel
Enrique Leyva
Fabiola Ferrero
Federico Estol
Félix Márquez
Fernanda Pineda
Gabriel Gómez
Gastón Zilberman
Gleeson Paulino
Gui Christ
Irina Werning
Javier Álvarez
Johanna Alarcón
Juan Brenner
Karla Read
Marcelo Pérez del Carpio
Marisol Méndez
Mauricio Holc
Pedro Silveira
Rafael Paiva
Salvador Saavedra
Sara Aliaga
Sara Meneses Cuapio
Sebastián Gil Miranda
Sebastián Lopez Brach
Sergio Pontier
Silvana Trevale
Thais Vandanezi
Viridiana
Xavier Revuelta
For more about the PhotoVogue Festival 2025, check out: All you need to know about the PhotoVogue Festival 2025
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Hotel Panorama celebrates a major construction milestone as its structural build is completed
bringing Adelaide’s most exciting new hospitality project closer to its 2026 opening
The Hurley Hotel Group’s latest project has just hit a major milestone
with the completion of the structural build celebrated at a ‘Topping Off’ party on Wednesday
and the finished product is shaping up to be something truly special
Hotel Panorama is the group’s most biggest project to date
With plans to open its doors in March 2026
this new addition to Adelaide’s southern suburbs is set to offer more than just a place to stay for visitors
It’s going to be a great spot for locals too
will offer stunning ocean views that are sure to impress
drawing visitors from across Adelaide to unwind and relax
two function rooms on the top floor will boast breathtaking vistas of the Adelaide Hills
providing the ideal setting for special events
and a gaming room will be on the ground floor
you’ll be able to hang out in the large outdoor area featuring a giant three-metre screen under a gum tree
or just enjoying the vibe catching up with friends or family
Hotel Panorama will have 77 rooms across three floors
The hotel’s location will be extremely handy for people visiting the nearby Flinders Hospital
and the South Australian Leisure and Aquatic Centre
Wine lovers are already enjoying the Panorama Hurley Cellars which has opened to the public
The Cellars feature a carefully selected range of premium wines
and a tasting table for regular masterclasses
couldn’t be more excited about the project’s progress
“We are thrilled to reach this stage—the highest point of the structural build of Hotel Panorama
is something entirely new for the southern suburbs of Adelaide
Oakley also noted the job opportunities the hotel will bring to the community
we’ll be hiring between 150 and 200 new staff members
which will add to the over 650 people already working with the Hurley Hotel Group
It’s exciting to be creating new jobs and expanding our team.”
this hotel is shaping up to be the go-to spot in the southern suburbs
Get ready to experience it all when it opens in March 2026
Hotel PanoramaWhere: Goodwood Road, PanoramaWhen: Completed March 2026For more information, click here
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COLORADO SPRINGS — There are now gates at the entrance to Panorama Park in Colorado Springs
It is a safety measure driven by locals watching out for their neighborhood park
a multi-million-dollar renovation to the park was completed
“It had some tremendous input from the neighborhoods and neighborhood groups
and they've done an outstanding job of just keeping the neighborhood watch going at panorama
We've had a lot of feedback,” said Eric Becker with Colorado Springs Parks
really looking out after the park to make sure they're protected,” said Becker
Neighbors noticed a difference between people hanging out at the park for fun during the day and questionable activity after park hours end
Gates have proven a successful solution to preventing illegal activity at more than a dozen other parks Colorado Springs parks
At memorial park gates were installed in 2023 as one tool of a safey plan that also included improved lighting and security cameras
Police data shows a 21-percent drop in criminal offenses compared to the previous year
“It's been very effective at reducing the numbers of after out call outs by CSPD
because of neighbors watching out for the park,” said Becker
Gates are expected to also help at Panorama Park
it's worth noting that service members who retire and then teach at the Academy are considered civilian instructors
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Baby food pouches found to fall short on nutrition
Some of the UK’s best-known baby food brands have come under fire following a BBC Panorama investigation that found widespread nutritional shortcomings and potentially misleading marketing practices in popular baby food pouches
fruit and yogurt pouches from Ella’s Kitchen
revealed that several products contain high levels of free sugars – sometimes more than a one-year-old should consume in a day – and very low amounts of key nutrients like iron and vitamin C
Savoury pouches marketed as meals were found to contribute less than 5% of an infant's recommended daily iron intake
One meat-based pouch from Heinz contained just 0.3mg of iron per serving – a fraction of the 7.8mg required daily
Some fruit pouches promoted as containing 'no added sugar' were found to contain the equivalent of four teaspoons of sugar
due to the blending process breaking down fruit cell walls
a form of sugar that dental experts say is especially damaging for babies
Vitamin C degradation during manufacturing was also flagged
with Piccolo’s Pure Mango pouch showing virtually no vitamin C remaining after processing
Experts told the BBC that such products should only be used occasionally as part of a varied weaning diet
and that parents are being misled by “halo marketing” — phrases such as “packed with goodness” or “as nutritionally good as homemade” giving a false impression of healthfulness
head of policy and advocacy at The Food Foundation
said: “Policies are urgently needed to protect the health of our youngest children and ensure they have the best start in life
The existing early years nutrition policies are weak
and the extent of claims on packaging is just one area where the government needs to step up to protect both children and their parents from misleading marketing.”
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CommentThere’s a shocking amount of sugar hidden in baby food pouches – and parents have no ideaCaregivers looking for convenience food for their children trust labels that promise nutrition and ‘no nasties’, writes Dayna Brackley
But the real betrayal is that brands sell products high in sugar and low in vital nutrients – under a veneer of ‘health’
Tonight, BBC Panorama exposes a reality many parents will find difficult to stomach: the baby food pouches and snacks lining our supermarket shelves are failing our youngest children
I used these pouches, too. Ten years ago, as a tired, time-pressed mum, I trusted these products
The packaging was friendly; the labels promised “organic” and “no nasties”
Now, after years working in food policy, I can see how misplaced that trust was. These weren’t simply convenient options – they were sugar-laden products shaping my children’s diets at a crucial stage
which analysed over 600 baby and toddler foods sold across the UK’s biggest supermarkets
A quarter of all products were so high in sugar that they would trigger a front-of-pack warning label under World Health Organisation guidelines
More than 40 per cent of main meals had high sugar levels
and over half of snacks contained added sugars
In fruit pouches – now a common part of many young children’s diets – 71 per cent of the calories came from sugar
These products were also consistently cheaper, making the sweetest options even more likely to end up in shopping baskets
Nearly half of parents say they use these products most of the time
and four in 10 parents with babies under six months use them every day
The consequences are real – and already visible. Babies are being fed foods that are too sweet, too smooth and introduced too early. Experts, including the British Dental Association, have warned that baby foods high in sugar can lead to poor dental health
Nursery managers and dietitians have raised the alarm that toddlers are arriving at nursery unable to handle textured meals
Research indicates that frequent use of these products can also contribute to preferences for sweet food and obesity
No parent should feel guilty for having to resort to using convenience foods – but aggressive marketing has made it harder to know what’s truly good for babies
Brands present themselves as trusted partners – promoting health
care and sustainability – in an attempt to build brand loyalty under the guise of helpfulness
The same brands line the streets and shelves as children grow
Products flaunting “30 per cent less sugar” with an asterisk
five types of sugar and multiple kinds of chocolate
This isn’t about supporting parents; it’s about selling sugary snacks under a veneer of health
Parents deserve better than sinister marketing disguised as care
The rules on baby food are being broken – and the government knows it
There are no limits on how much sugar can be added to baby foods
Six years ago, a review by Public Health England found many baby foods were too high in sugar and salt. Since then, the Office for Health Improvement and Disparities (OHID) has failed to deliver promised voluntary guidelines – and even if they do
the World Health Organisation’s model sets clear limits
bans misleading claims and protects against the early introduction of solids – although the UK has not adopted it
The House of Lords has called for urgent action. A recent report on food and obesity recommended banning the marketing of follow-on and toddler milks
and introducing mandatory standards for all baby and toddler foods by the end of 2025
The government responded by claiming to have “comprehensive regulations” already in place – despite baby foods being marketed for babies as young as four months
in clear conflict with NHS official advice regarding weaning
Since the Panorama investigation was launched
brands have confirmed they are set to change this practice – though for many parents
And if you’re as angry as I am, take action. It’s easy to email your MP – the Children’s Food Campaign has a ready-to-go message you can send today
When brands put profit over babies’ health
it’s the government’s job to step in – not look away
Dayna Brackley is a partner at food policy consultancy Bremner & Co and specialises in child health
Panorama: The Truth About Baby Food Pouches is on BBC1 at 8.00pm
More aboutSugarBBC PanoramaChild HealthBaby foodJoin our commenting forumJoin thought-provoking conversations, follow other Independent readers and see their replies
The Blue Devils competed in the Panorama Farms Invitational Saturday
their final race before postseason competition
featured a few ACC cross country powerhouses in Wake Forest
but Duke held its own and made sizable improvements
The men’s team finished at an impressive fifth place out of 18 teams and the women’s team placed eighth out of 14 teams
“This is the most positive our team has been,” said head coach Kevin Jermyn after the race
and we aren’t where we hope to be by the end of the season
but we have made significant progress.” Though this race was only the second regular-season meet that the top group of Duke’s runners competed in
the team came together nicely just in time to head into the postseason
sophomore Hattie Reynolds and freshman Caroline Hood stole the show
“This was the best cross country race that I’ve ever seen from Hattie and Caroline," Jermyn said
Caroline had a muscle strain that bothered her in Chicago
but today was a reinforcement of the type of person we are seeing week in and week out
They are both running at a level that is going to make us competitive in both the ACC and nationally.”
and sophomore Lindsay Hausman (78th) rounded out the top-five for the women’s squad
The men’s side showed promise as just 30 seconds separated the first from the fifth best runners for the Blue Devils
What’s most notable about Stanley’s performance was the way in which he moved up throughout the race
Stanley came through the 2K mark all the way back in 45th
but then jumped to 39th after the 4K and up to 27th after the 6K
He then overtook six more runners in the final two kilometers to finish 21st overall
Only 12 seconds behind him was senior Duncan Miller
finished out a strong performance from the men’s squad
Jermyn believes that this race has been a strong representation of the training the team has put in over the past several months
He also notes that with every race comes more experience
and the team is starting to put what they’ve learned to use
“Having one race under our belt led to a lot of natural improvement
the only time we go all-out is on race day
We use early season races as the most important workout in each two-week training cycle,” he said
Having just completed their final race of the regular season, the Blue Devils turn their attention to the postseason. Their journey will begin at the ACC championships Nov. 1 at the WakeMed Soccer Park in Cary. The team is familiar with this course as they competed in the Adidas XC Challenge at the same location back in September
Jermyn made it clear that while the Blue Devils had a strong showing today
“We want to place well at the ACC championships and the NCAA regionals,” Jermyn said
He described that the way to achieve these goals is by “making sure each runner has an idea of what helps them run their best race and making sure we are optimizing as many individual game plans as we can within a team setting.”
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Mars.Perseverance Rover Panorama of Mars’ Jezero Crater Jet Propulsion Laboratory https://www.jpl.nasa.gov/ Dec
2024Travel along a steep slope up to the rim of Mars’ Jezero Crater in this panoramic image captured by NASA’s Perseverance just days before the rover reached the top
The scene shows just how steep some of the slopes leading to the crater rim can be
The rover used its Mastcam-Z camera system to capture this view on Dec
the rover was about 1,150 feet (350 meters) from
the top of the crater rim - a location the science team calls “Lookout Hill.” The rover reached Lookout Hill on Dec
10 after a climb of 3½ months and 1,640 vertical feet (500 vertical meters)
For more about Perseverance: science.nasa.gov/mission/mars-2020-perseverance
NASA Orbiter Spots Curiosity Rover Making Tracks to Next Science Stop
Image.
Curiosity Looks Downslope From the Sulfate Unit
Image.
Image.
Curiosity on the Road to Boxwork Formations
News.
NASA’s Curiosity Rover May Have Solved Mars’ Missing Carbonate Mystery
Image.
Curiosity Surveys the 'Ubajara' Sampling Site on Mars
News.
NASA’s Perseverance Mars Rover Studies Trove of Rocks on Crater Rim
Image.
Image.
Image.
It took over a decade to make and includes more than 600 photos
The massive 42,208 by 9,870-pixel panorama is the largest photomosaic ever created using Hubble Space Telescope observations
The vast mosaic features 200 million stars
which is still just a fraction of the estimated one trillion stars in Andromeda
the mosaic’s details will help scientists learn more about Andromeda’s history
including distant mergers with smaller satellite galaxies
As the Milky Way galaxy’s nearest neighbor
for whom the Hubble Space Telescope is named
then described as a “spiral nebula,” was actually far outside the Milky Way galaxy
people believed the Milky Way comprised the entire Universe
Hubble’s discovery instantly transformed humanity’s understanding of the cosmos
Andromeda’s impact continues to be acutely felt
as it offers vital insights into the Milky Way galaxy
“Without Andromeda as a proxy for spiral galaxies in the universe at large
astronomers would know much less about the structure and evolution of our own Milky Way
That’s because we are embedded inside the Milky Way
This is like trying to understand the layout of New York City by standing in the middle of Central Park,” NASA explains
“With Hubble we can get into enormous detail about what’s happening on a holistic scale across the entire disk of the galaxy
You can’t do that with any other large galaxy,” explains principal investigator Ben Williams of the University of Washington
While the newer James Webb Space Telescope has stolen some of Hubble’s legendary thunder
the space telescope remains vital to astronomy and physics
Since Andromeda is so large and relatively close
although still 2.5 million light-years away
NASA describes the task of photographing Andromeda as “herculean.”
“Because the galaxy is a much bigger target on the sky than the galaxies Hubble routinely observes
which are often billions of light-years away
The full mosaic was carried out under two Hubble programs
spanning more than a decade,” NASA explains
The panorama began with the Panchromatic Hubble Andromeda Treasury (PHAT) program about 10 years ago
Hubble’s Advanced Camera for Surveys and Wide Field Camera 3 captured near-ultraviolet
and near-infrared wavelength photos of Andromeda’s northern half
The Panchromatic Hubble Andromeda Southern Treasury (PHAST) program followed
adding about 100 million stars from the southern half of Andromeda
The combined programs cover Andromeda’s entire disk
seen nearly edge-on and tilted by 77 degrees relative to Earth’s view of the galaxy
“This detailed look at the resolved stars will help us to piece together the galaxy’s past merger and interaction history,” says Williams
It looks like it has been through some kind of event that caused it to form a lot of stars and then just shut down,” adds Daniel Weisz at the University of California
“This was probably due to a collision with another galaxy in the neighborhood.”
As brilliant and detailed as Hubble’s dataset of Andromeda
the upcoming Nancy Grace Roman Space Telescope holds even more promise
Roman is basically a wide-angle version of Hubble and will capture the equivalent of 100 high-resolution Hubble photos in a single exposure
Data from Roman and images collected by the James Webb Space Telescope will complement Hubble’s remarkable contributions
Clifton Johnson (Northwestern); Image Processing: Joseph DePasquale (STScI)
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BOSTON, Aug. 8, 2024 /PRNewswire/ -- Panorama Education
an education technology company that helps students achieve academic success and well-being
today announced the appointment of Chief Financial Officer Catherine Chang
Catherine will lead the company's financial operations and strategic growth initiatives to help address the diverse needs of students
parents and school districts across the nation
Catherine's appointment follows the recent additions to Panorama Education's executive team
Chief Marketing Officer Melissa Gardner and Chief Revenue Officer Trey Yost
Catherine is a seasoned financial executive
joining Panorama from a global cybersecurity firm
where she served as Chief Financial Officer and led a number of strategic acquisitions and capital raises
Catherine held a number of different roles including Chief Strategy Officer and Head of U.S
focusing on corporate strategy and development
she served as Vice President in Firm Strategy & Execution and Office of the Chief Operating Officer at Morgan Stanley
where she evaluated and advised senior management on principal mergers
as well as strategic opportunities for the firm
"Catherine's keen understanding of what it takes for a business to have an impact at scale is a great asset to our leadership team," said Panorama Education CEO and Co-founder
"Her experience building strategic and collaborative finance teams
and developing high-quality companies positioned for long-term success
will power Panorama to continue delivering innovative solutions that help overcome the challenges facing our schools—like chronic absenteeism and reading proficiency."
Catherine joins the Panorama team with 15+ years of experience in finance
leading high-performing teams and driving organizational growth in dynamic environments
where she earned her Bachelor of Arts in Economics and Psychology
About Panorama EducationPanorama Education is an education technology company founded in 2012 that helps students achieve academic success and well-being
and gives schools and school districts a platform to hear what families
students and teachers need in the classroom
Educators use Panorama's software platform to understand and support students across academics
District leaders use the same platform to track progress toward strategic goals
Panorama is proud that its platform is used to support 15 million students in 25,000 schools and 2,000 districts across the United States
For more information, visit www.panoramaed.com
Media ContactStephanie Reynolds(415) 320-6143[email protected]
a leading education technology company that enables student academic success and well-being
Computer Software
Computer Software
Education
Personnel Announcements
has completed the structural build of the hotel
with the project set to be completed by March 2026
The five-storey $60 million hotel on Goodwood Road will include a basement
gaming room and a sports bar on the ground floor that leads to an outdoor area with a three-metre outdoor screen
Hotel Panorama General Manager Scott Oakley said the hotel’s new rooftop bar
will have panoramic views overlooking the city
The top floor will also have two function rooms with views of the Adelaide Hills
Wonderland aims to provide “an exciting space and something that has not been done before in this area,” Oakley said
There will be three floors of accommodation with 77 rooms
including 26 serviced apartments with one and two-bedroom options and a honeymoon suite
Oakley said Hotel Panorama expects guests who are visiting the nearby Flinders Hospital
Flinders University and Tonsley Innovation Precinct
A render of The Hurley Group’s Hotel Panorama
and a function room is starting within the next couple of weeks
The hotel is being built by South Australian family-owned company Sarah Constructions
with previous projects including d’Arenberg’s The Cube and the Hurley’s Marion Hotel
The hotel design was done by Cox Architecture
who have also designed projects such as the Adelaide Oval Hotel
Adelaide Botanic High School and Her Majesty’s Theatre redevelopment
Oakley said the hotel will look to employ “somewhere between 150 to 200 new staff members
which will add to the over 650 staff that the Hurley Hotel Group currently employs”
Hurley Hotel Group’s Anna Hurley said she was thrilled to be investing in the future of the area
daily“The Hotel Panorama represents the largest investment in the history of our family business,” she said
as part of the Hotel Panorama project is open with a range of premium wines
imported and local beers and high-end spirits
The cellar includes a three-lane drive-thru
temperature-controlled walk-in cool room and a tasting table
“We’re really excited to have this come to life when the project completes in March 2026,” Oakley said
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The owners of two Vietnamese eateries in Adelaide have been fined more than $800,000 for “reprehensible conduct”, including underpaying one worker by nearly $60,000.
The Hurley Hotel Group’s latest project, Hotel Panorama, has completed the structural build of the hotel, with the project set to be completed by March 2026.
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InDaily South Australia acknowledges the Traditional Owners of country throughout South Australia and recognises their continuing connection to land, waters and culture. We pay our respects to their Elders past, present and emerging.
In response to growing regulatory requirements and the proliferation of tools for measuring the impacts and risks associated with environmental issues
this panorama is designed to provide an overview of the ecosystem and help organizations navigate through the range of tools available
companies face crucial challenges in assessing and managing their environmental impacts and risks
They must respond to growing regulatory pressures
Pillar 3 ESG and Solvency 2 (for the banking and insurance sectors)
as well as to the increasingly demanding expectations of investors and other stakeholders
These pressures can have major consequences on their activities: transforming the business model to respect planetary limits or improving traceability and control of the supply chain are just some of the challenges that all economic players must now face
a number of tools are emerging to help companies manage their sustainable performance and draw up transition plans
there are general ESG reporting tools that can address all themes
There are also a number of specialized carbon reporting tools
These two types of tools are not included in this panorama
but are the subject of forthcoming Wavestone publications
This panorama focuses exclusively on natural resources and materials recovery
which represent a relatively less mature field of ESG analysis on the market
Many solutions are being developed to help companies gain better control of their environmental data
whether this relates to their own activities or to their value chain
These solutions adopt different positioning
the aim of this panorama is to decipher the environmental data market by offering a structured analysis of the various solutions available
It covers BtoB tools for assessing risks and/or impacts in the fields of climate change (physical risks only
Based on documentary research (using Wavestone’s Research & Knowledge Center and additional research) and through exchanges with tool providers
our experts have listed around a hundred solutions
according to 4 analytical axes responding to the analysis framework and requirements of the CSRD:
The themes covered are aligned with 4 of the 5 CSRD environmental standards (ESRS – European Sustainability Reporting Standards)
Tools can either assess the company’s impact on natural resources
or the risks associated with natural resources for companies
or even focus specifically on product traceability from an environmental point of view
These tools can be applied in a variety of ways
They can collect / propose data at the level of a product
power plants) or a company’s value chain (suppliers and origin of materials)
Each tool has been analyzed according to its ability to address multi/trans-sectoral issues
or to deal with problems specific to certain sectors (e.g
The figures presented are specific to the study carried out and to the 100 tools listed in this panorama
there has been a sharp increase in the number of tools for measuring impacts and risks on natural resources
This increase is directly linked to a need to strengthen companies’ sustainable performance management
Faced with growing customer demand for compliance
some tools are adapting to comply with new environmental regulations such as the CSRD or ISO standards
in order to facilitate data reporting and commitments
Tools for measuring impacts and risks on resources are increasingly choosing to specialize in a particular sector of activity (financial
for example) in order to target certain emerging needs in specific fields
Tools are using cross-methodologies and increasingly employing Artificial Intelligence to aggregate data and perform complex calculations to obtain more accurate and efficient results
Panorama of data management tools for natural resources and materials valorization
Around a hundred companies are listed under 5 categories:
Following analysis of the 100 tools listed
a limited sample of 17 tools was selected for detailed fact sheets
Media coverage: the tools selected enjoy a certain amount of media coverage (press
etc.) and have references with companies of similar size and in similar sectors to those of our customers
Thematic coverage: tools have been selected to be representative of the various themes covered by the radar
but particular attention was paid to the financial and industrial sectors
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